CN105497136A - Five flower tea effervescent tablet and preparation method thereof - Google Patents

Five flower tea effervescent tablet and preparation method thereof Download PDF

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Publication number
CN105497136A
CN105497136A CN201510901782.0A CN201510901782A CN105497136A CN 105497136 A CN105497136 A CN 105497136A CN 201510901782 A CN201510901782 A CN 201510901782A CN 105497136 A CN105497136 A CN 105497136A
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flower tea
flos
effervescent tablet
powder
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保泽庆
陈妙茹
吴伟斌
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Zhaoqing Medical Higher College
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
    • A61K36/575—Magnolia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers

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Abstract

The invention discloses a five flower tea effervescent tablet, which comprises the following components in parts by mass: 6 to 8 parts of five flower tea extract dry powder, 15 to 20 parts of white granulated sugar, 45 to 55 parts of sodium bicarbonate, 3 to 7 parts of polyethylene glycol, and 15 to 25 parts of sodium tartrate. The invention also discloses a preparation method of the five flower tea effervescent tablet. The five flower tea effervescent tablet has the advantages that the traditional herbal tea is prepared into the effervescent tablet, so that the production and carrying are convenient; the effervescent tablet can be drunk when the effervescent tablet is made; the effervescent tablet is suitable for the old and the young; the problems of waste in time and troublesome in the use process of the traditional herbal tea are solved; the utilization value of the herbal tea is greatly improved.

Description

A kind of five-flower tea effervescent tablet and preparation method thereof
Technical field
The invention belongs to Chinese herbal medicine preparation technology field, be specifically related to a kind of five-flower tea effervescent tablet, the invention still further relates to a kind of preparation method of five-flower tea effervescent tablet.
Background technology
Five-flower tea is a kind of folks of china tradition beverage, and one of herbal tea that Cantonese often drinks, drinks when being especially applicable to summer.At present, the use for five-flower tea generally still rests on traditional herbal tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Flos Lonicerae is obviously reduced simultaneously, greatly hinders the promotion and application of five-flower tea.Therefore, at present in the urgent need to providing a kind of honeysuckle health-care beverage conveniently drunk, to adapt to the demand of consumers in general, significantly promoted the quality of life of people.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, and the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Have in current five-flower tea effervescent tablet that disintegrate is slow, active component in five-flower tea is difficult to the problem that is dissolved out.
Summary of the invention
The object of this invention is to provide a kind of five-flower tea effervescent tablet, solve that the disintegrate that exists in prior art is slow, composition and effectiveness in five-flower tea is difficult to the problem that is dissolved out.
Another object of the present invention is to provide a kind of preparation method of five-flower tea effervescent tablet.
First technical scheme of the present invention is, a kind of five-flower tea effervescent tablet, comprises following component according to mass parts: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts.
In technique scheme:
Five-flower tea extract dry powder comprises following component according to mass parts: Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 32 parts-38 parts.
Second technical scheme of the present invention is, a kind of preparation method of five-flower tea effervescent tablet, comprises the following steps:
Step 1, prepare five-flower tea extract dry powder;
Step 2, weighing, weigh following component according to weight portion: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts;
Step 3, by white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate respectively porphyrize, crosses 50 mesh sieves and makes its mix homogeneously;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare five-flower tea effervescent tablet.
In technique scheme:
Prepare five-flower tea extract dry powder in step 1 to be specially:
Step 1.1, weighing: weigh following component according to mass parts: Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 28 parts-32 parts;
Step 1.2, above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder;
Step 1.3, extract and filter: in extraction pot, add the water being equivalent to five-flower tea mixed powder 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds five-flower tea mixed powder, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is five-flower tea extract dry powder.
Spraying dry pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
Grain made parameter in step 4 is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
The invention has the beneficial effects as follows: 1, the active ingredient of the Flos Lonicerae of this five-flower tea effervescent tablet, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae can be extracted fully.
2, disintegration of five-flower tea effervescent tablet that this formula and preparation method obtain can reach 105s, solve the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to five-flower tea and the screening to gas-producing disintegrant and lubricant etc., make five-flower tea effervescent tablet of the present invention obtain best effervescent effect.
Herbal tea is as Chinese tradition beverage, and the herbal tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a clay pot and spend several hours and go decoction one to take herbal tea.Therefore, traditional herb tea is made effervescent tablet, is convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in detail.
The invention provides a kind of five-flower tea effervescent tablet, comprise following component according to mass parts: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts.
Wherein, five-flower tea extract dry powder comprises Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 32 parts-38 parts.
The present invention also provides a kind of preparation method of five-flower tea effervescent tablet, comprises the following steps:
Step 1, prepare five-flower tea extract dry powder,
Step 1.1, weighing: weigh following component according to mass parts: Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 28 parts-32 parts;
Step 1.2, above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder;
Step 1.3, extract and filter: in extraction pot, add the water being equivalent to five-flower tea mixed powder 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds five-flower tea mixed powder, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min;
Step 2, weighing, weigh following component according to weight portion: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts;
Step 3, by white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate respectively porphyrize, crosses 50 mesh sieves and makes its mix homogeneously;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
Be made up of Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae; Flos Lonicerae heat-clearing and toxic substances removing, wind-heat dissipating in side; Flos Plumeriae Acutifoliae clearing away summer-heat, bowel relieving antidiarrheal, relieving cough and resolving phlegm; Flos Bombacis Malabarici Flos Magnoliae is then effective for rhinitis, because while flu, rhinitis inevitably also there will be; Flos Sophorae cooling blood for hemostasis, purging liver-fire; Flos puerariae lobatae heat-clearing and toxic substances removing, promoting digestion, protecting liver; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, thus heat clearing away is played, removing heat from blood, effect of removing toxic substances altogether by full side; There is heat clearing away, detoxify, relieve summer heat dry, lower the intestines and stomach thorn heat, diuresis, removing heat from blood, prevention anemopyretic cold in summer and grippal effect.
Embodiment 1
A preparation method for five-flower tea effervescent tablet, comprises the following steps: weigh following component according to mass parts: Flos Lonicerae 29 parts, Flos Plumeriae Acutifoliae 18 parts, Flos Magnoliae 14 parts, 6 parts, Flos Sophorae and Flos puerariae lobatae 29 parts; Above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 28kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder; In extraction pot, add the water being equivalent to five-flower tea mixed powder 9 times of weights, room temperature is heated to 84 DEG C, adds five-flower tea mixed powder, stirs extraction 9 minutes, and 250 mesh filter screens filter; Filtrate is heated to 70 DEG C, be decompressed to 18KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 29000r/min; Following component is weighed: 7 parts, five-flower tea extract dry powder, white sugar 18 parts, sodium bicarbonate 49 parts, Polyethylene Glycol 5 parts, sodium tartrate 19 parts according to weight portion; By white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate is porphyrize respectively, crosses 50 mesh sieves and makes its mix homogeneously; Mixed powder is granulated, flattens, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 75 DEG C, and pressure is 0.55MP.
Embodiment 2
A preparation method for five-flower tea effervescent tablet, comprises the following steps: weigh following component according to mass parts: Flos Lonicerae 28 parts, Flos Plumeriae Acutifoliae 25 parts, Flos Magnoliae 12 parts, 8 parts, Flos Sophorae and Flos puerariae lobatae 28 parts; Above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 25kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder; In extraction pot, add the water being equivalent to five-flower tea mixed powder 10 times of weights, room temperature is heated to 75 DEG C, adds five-flower tea mixed powder, stirs extraction 12 minutes, and 200 mesh filter screens filter; Filtrate is heated to 80 DEG C, be decompressed to 15KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min; Following component is weighed: 6 parts, five-flower tea extract dry powder, white sugar 20 parts, sodium bicarbonate 45 parts, Polyethylene Glycol 7 parts, sodium tartrate 15 parts according to weight portion; By white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate is porphyrize respectively, crosses 50 mesh sieves and makes its mix homogeneously; Mixed powder is granulated, flattens, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C, and pressure is 0.6MP.
Embodiment 3
A preparation method for five-flower tea effervescent tablet, comprises the following steps: weigh following component according to mass parts: Flos Lonicerae 32 parts, Flos Plumeriae Acutifoliae 10 parts, Flos Magnoliae 15 parts, 5 parts, Flos Sophorae and Flos puerariae lobatae 32 parts; Above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 30kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder; In extraction pot, add the water being equivalent to five-flower tea mixed powder 8 times of weights, room temperature is heated to 90 DEG C, adds five-flower tea mixed powder, stirs extraction 8 minutes, and 300 mesh filter screens filter; Filtrate is heated to 60 DEG C, be decompressed to 20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 30000r/min; Following component is weighed: 8 parts, five-flower tea extract dry powder, white sugar 15 parts, sodium bicarbonate 55 parts, Polyethylene Glycol 3 parts, sodium tartrate 25 parts according to weight portion; By white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate is porphyrize respectively, crosses 50 mesh sieves and makes its mix homogeneously; Mixed powder is granulated, flattens, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 78 DEG C, and pressure is 0.5MP.
Embodiment 4
A preparation method for five-flower tea effervescent tablet, comprises the following steps: weigh following component according to mass parts: Flos Lonicerae 30 parts, Flos Plumeriae Acutifoliae 14 parts, Flos Magnoliae 13 parts, 7 parts, Flos Sophorae and Flos puerariae lobatae 31 parts; Above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 26kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder; In extraction pot, add the water being equivalent to five-flower tea mixed powder 8.5 times of weights, room temperature is heated to 78 DEG C, adds five-flower tea mixed powder, stirs extraction 10 minutes, and 235 mesh filter screens filter; Filtrate is heated to 65 DEG C, be decompressed to 16KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28500r/min; Following component is weighed: 6.5 parts, five-flower tea extract dry powder, white sugar 19 parts, sodium bicarbonate 52 parts, Polyethylene Glycol 4 parts, sodium tartrate 22 parts according to weight portion; By white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate is porphyrize respectively, crosses 50 mesh sieves and makes its mix homogeneously; Mixed powder is granulated, flattens, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 76 DEG C, and pressure is 0.58MP.
Embodiment 5
A preparation method for five-flower tea effervescent tablet, comprises the following steps: weigh following component according to mass parts: Flos Lonicerae 31 parts, Flos Plumeriae Acutifoliae 22 parts, Flos Magnoliae 13.5 parts, 7.5 parts, Flos Sophorae and Flos puerariae lobatae 29.5 parts; Above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 27kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder; In extraction pot, add the water being equivalent to five-flower tea mixed powder 9.5 times of weights, room temperature is heated to 85 DEG C, adds five-flower tea mixed powder, stirs extraction 11.5 minutes, and 275 mesh filter screens filter; Filtrate is heated to 72 DEG C, be decompressed to 19KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, be five-flower tea extract dry powder, wherein, spray drying condition is: pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 29500r/min; Following component is weighed: 7.5 parts, five-flower tea extract dry powder, white sugar 17 parts, sodium bicarbonate 48 parts, Polyethylene Glycol 6 parts, sodium tartrate 18 parts according to weight portion; By white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate is porphyrize respectively, crosses 50 mesh sieves and makes its mix homogeneously; Mixed powder is granulated, flattens, prepare five-flower tea effervescent tablet; Grain made parameter is aperture is 3.0, and compression ratio is 1:4, and temperature is 77 DEG C, and pressure is 0.56MP.
Comparative example
The effervescent tablet that common process prepares.
Below in conjunction with disintegration, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the granule assembled.No longer include gas to solution to overflow and the time difference T (s) dissolved is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind method " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, matched group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes five-flower tea effervescent tablet one week.
Diagnosis basis: disconnected standard is based on the standard of anemopyretic cold card relevant in " disease of tcm Standardization of diagnosis and curative effect ", and 1. heating, micro evil wind are trembled with fear, have a stuffy nose watery nasal discharge, sneeze, headache, general malaise.2. light red tongue or limit point red, platform book is yellow, floating and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, general pain, watery nasal discharge, pharyngalgia, pharyngeal congestion, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet the diagnostic criteria of traditional Chinese medical science anemopyretic cold card, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of pulmonary, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be trimester of pregnancy, women breast-feeding their children, and body constitution allergy sufferers.
Matched group: comparative example effervescent tablet, 3 times/d, 7d were 1 course for the treatment of.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Therapeutic outcome: in table 2.
Contrast with embodiments of the invention 1-5 and comparative example, draw the following conclusions.
Table 1 comparing result
Disintegration (s) Sensory evaluation scores (dividing) Hardness (N)
Embodiment 1 105s 100 62N
Embodiment 2 148s 98 64N
Embodiment 3 136s 85 65N
Embodiment 4 118s 90 67N
Embodiment 5 110s 95 60N
Comparative example 445s 38 63N
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
Group Total number of cases Recovery from illness Effective Effectively Invalid Total effective rate
Embodiment 1 30 26 3 1 1 96.7％
Embodiment 2 30 22 2 2 4 86.7％
Embodiment 3 30 16 6 5 3 90％
Embodiment 4 30 18 5 2 5 83.3％
Embodiment 5 30 21 3 2 4 86.7％
Comparative example 30 6 4 5 15 50％
As shown in Table 2, illustrate that the active ingredient ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet treatment anemopyretic cold effect of the present invention is higher than existing five-flower tea effervescent tablet.
1., according to the inventive method, the application manually produces 150 batches of five-flower tea effervescent tablets altogether, conforming product rate 100%;
2. according to national standard, 24 months five-flower tea effervescent tablet effect duration, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-5 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, the screening by the proportioning to five-flower tea and the screening to gas-producing disintegrant and lubricant etc., make five-flower tea effervescent tablet of the present invention obtain best effervescent effect;
4. can be found out by above-mentioned result of the test, it is fast that five-flower tea effervescent tablet of the present invention has disintegrate compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the five flower effervescent tablets prepared, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.

Claims (6)

1. a five-flower tea effervescent tablet, is characterized in that, comprises following component according to mass parts: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts.
2. five-flower tea effervescent tablet according to claim 1, it is characterized in that, described five-flower tea extract dry powder comprises following component according to mass parts: Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 32 parts-38 parts.
3. a preparation method for five-flower tea effervescent tablet, is characterized in that, comprises the following steps:
Step 1, prepare five-flower tea extract dry powder;
Step 2, weighing, weigh following component according to weight portion: 6 parts-8 parts, five-flower tea extract dry powder, white sugar 15 parts-20 parts, sodium bicarbonate 45 parts-55 parts, Polyethylene Glycol 3 parts-7 parts, sodium tartrate 15 parts-25 parts;
Step 3, by white sugar, sodium bicarbonate, Polyethylene Glycol, sodium tartrate respectively porphyrize, crosses 50 mesh sieves and makes its mix homogeneously;
Step 4, the mixed powder prepared in step 3 to be granulated, flatten, prepare five-flower tea effervescent tablet.
4. the preparation method of five-flower tea effervescent tablet according to claim 3, is characterized in that, prepares five-flower tea extract dry powder and be specially in described step 1:
Step 1.1, weighing: weigh following component according to mass parts: Flos Lonicerae 28 parts-32 parts, Flos Plumeriae Acutifoliae 10 parts-25 parts, Flos Magnoliae 12 parts-15 parts, 5 parts-8 parts, Flos Sophorae and Flos puerariae lobatae 28 parts-32 parts;
Step 1.2, above-mentioned Flos Lonicerae, Flos Plumeriae Acutifoliae, Flos Magnoliae, Flos Sophorae and Flos puerariae lobatae are ground into tea powder respectively, cross 50 mesh sieves, through 25-30kGy 60co-gamma-ray irradiation, by five kinds of tea powder mixing, prepares five-flower tea mixed powder;
Step 1.3, extract and filter: in extraction pot, add the water being equivalent to five-flower tea mixed powder 8-10 and doubly weighing, room temperature is heated to 75-90 DEG C, adds five-flower tea mixed powder, stirring and extract 8-12 minute, 200-300 mesh filter screen and filter;
Step 1.4, concentrate and carry out spraying dry: filtrate is heated to 60-80 DEG C, be decompressed to-15KPa-20KPa when being concentrated into the 1/4-1/3 of total filtrate weight, spraying dry makes dry powder, is five-flower tea extract dry powder.
5. the preparation method of five-flower tea effervescent tablet according to claim 4, is characterized in that, described spraying dry pressure: 50Mpa, feeding temperature: 65 DEG C, inlet temperature: 195 DEG C, leaving air temp: 95 DEG C; Rotating speed is 28000r/min-30000r/min.
6. the preparation method of five-flower tea effervescent tablet according to claim 4, is characterized in that, the grain made parameter in described step 4 is aperture is 3.0, and compression ratio is 1:4, and temperature is 72 DEG C-78 DEG C, and pressure is 0.5MP-0.6MP.
CN201510901782.0A 2015-12-08 2015-12-08 Five flower tea effervescent tablet and preparation method thereof Pending CN105497136A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102273537A (en) * 2011-08-26 2011-12-14 宁国市亿邦生物科技有限公司 Litsea Coreana leve. Var. effervescent tablets and preparation method thereof
CN102552462A (en) * 2012-01-12 2012-07-11 中山火炬职业技术学院 Effervescent preparation as well as preparation method and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102273537A (en) * 2011-08-26 2011-12-14 宁国市亿邦生物科技有限公司 Litsea Coreana leve. Var. effervescent tablets and preparation method thereof
CN102552462A (en) * 2012-01-12 2012-07-11 中山火炬职业技术学院 Effervescent preparation as well as preparation method and application thereof

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叶强等: "《民间药疗食谱》", 31 August 2000 *

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