CN104800706A

CN104800706A - Medicine for treating fracture of femoral shaft and preparation method thereof

Info

Publication number: CN104800706A
Application number: CN201510234819.9A
Authority: CN
Inventors: 刘祥锋; 赵振荣
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-11
Filing date: 2015-05-11
Publication date: 2015-07-29

Abstract

The invention discloses a medicine for treating fracture of the femoral shaft and a preparation method thereof. The medicine comprises the following raw medicinal materials: Chinese angelica, adhatoda ventricosa, root of common peony, asiatic toddalia root, dried rehamnnia root, rubia yunnanensis, rhizoma drynariae, circium japonicum, native copper, olibanum, cortex lycii radicis, myrrh, elderberry, hematoxylon, asplenium varians wall., caulis spatholobi, radix astragali preparata, madder, eucommia ulmoides, rhizoma sparganii, the seed of Chinese dodder, ixora chinensis, cutch, lamiophlomis rotata, giant knot weed, pig marrow, fir club moss and sea-buckthorn. The medicine for treating the fracture of the femoral shaft has the beneficial effects that the medicine has the effects of invigorating blood and generating new blood, setting broken bones and connecting tendons, promoting circulation and removing stasis, and replenishing essence and generating marrow; the medicine is mainly used for treating the femoral fracture in the middle period after the operation; the medicine has the advantages of rapid effect, high efficiency, accurate curative effect, short course of treatment, zero toxic side effect, low cost, and the like.

Description

A kind of medicine for the treatment of fracture of shaft of femur and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind of medicine for the treatment of fracture of shaft of femur and preparation method thereof.

Background technology

Femur is tubular bone the longest in human body.Femoral shaft to comprise under tuberosity the backbone of on 2-5 centimetre to condyle of femur 2-5 centimetre.Femoral shaft is surrounded by three groups of muscle.Muscular due to thigh, has dislocation after fracture and overlap more.The tendency of fracture far-end Chang Youxiang adduction displacement, the fracture of para-position, often has convex to be inclined to, and this displacement and angulation tendency, should note correcting and preventing in fractures.Under femur during 1/3 fracture, because blood vessel is positioned at the rear of Fracture of femur, and broken ends of fractured bone Chang Xianghou angulation far away of fracturing, therefore easily stab the popliteal artery and vein at this place.

The cause of disease: mostly be caused by powerful direct violence, also have person caused by a small amount of indirect violence.

Clinical manifestation: fracture of shaft of femur is many because of caused by violence, therefore should note the damage of systemic conditions and adjacent regions.1. general manifestation: fracture of shaft of femur is many to be caused due to serious wound, and amount of bleeding can reach 1000-1500 milliliters.As being opening or comminuted fracture, amount of bleeding may be larger, and patient can with the performance of the hemorrhagic shock such as blood pressure drops, pale complexion; As merged the damage of other position internal organs, the performance of shock may be more obvious.Therefore, for this type of situation, first also tightly dynamically should observe by Measure blood pressure, and note peripheral blood circulation.2. topical manifestations: the general character symptom can with fracture, comprises the limited and longitudinal percussion pain of pain, local swelling, angulation deformity, abnormal movement, limb function or bony crepitus.With the exception of this, should tentatively judge the position of fracturing according to the outside orthodontic condition of limbs, particularly during Lower Distal Extremities external rotatory position, noting not obscuring mutually with the performance of the hip injury such as intertrochanteric fracture, may be that two kinds of damages exist simultaneously sometimes.As being associated with nerve, blood vessel injury, dorsal artery of foot can be slight without beating or beating, and hinders the performance that limb has abnormal circulation, superficial sensibility exception or far-end can be had to be arranged muscle muscular strength abnormal.

Classification: the sorting technique that internal fixtion association of Switzerland (AO/ASIF) formulates is practical.Fracture of shaft of femur can be divided into A, B, C tri-class, is all kinds ofly divided into again 1,2,3 three hypotype.The auxiliary examination method mainly X ray examination of primary disease: for serious case, X ray examination can find the degree of impairment of fracturing in early days, and slight fracture, or the fracture of specific type (as stress type fracture), X ray examination can have following performance: early stage X line sign without exception, after 2-4 week, visible periosteal reaction and/or callus generate, in parallel shape or mound shape, hypertrophy periosteum and/or the low-density gap of visible parallel shape between callus and cortical bone, the serated fracture line that minority is walked crosswise compact zone as seen at the most bump pad of mid-plane of hypertrophy periosteum and/or callus and/or walked crosswise, As time goes on, hypertrophy periosteum develops into callus completely, density increases gradually, and low-density gap disappears between cortex, divide a word with a hyphen at the end of a line mutually with cortical bone in upper and lower two ends, cortical bone is equal to density when repairing completely, X line shows as limitation cortical bone and thickens.Primary disease such as complicated with acute is fractured, and also ruptures at the nearly section edge visible hyperplasia periosteum of fracture and/or callus thereupon, can be other with old fracture in conjunction with medical history, symptom etc.

Diagnosis: trauma history, thigh local swelling distortion is all serious, and Lower limb shortening, has obvious abnormal movement and bony crepitus when moving.Answer conventional determining blood pressure, P&R, define without shock or other systemic complications and important organ combined injury; Carefully to check color, the temperature of toes simultaneously and stretch the activity of bending, to have determined whether Major Vessels and (or) nerve injury.A few patients can merge fracture of femoral neck or dislocation of hip joint, does not omit when health check-up.Take the photograph the feature of position that X line anterioposterior and lateral film can clearly fracture, type and displacement, as the foundation for the treatment of.

Complication: owing to being subjected to powerful violence infringement during fracture, fracture of shaft of femur often with whole body panels with multiple site damage, or with the damage of body important organ.With regard to fracture of shaft of femur itself, owing to there being important neural blood vessel traveling inside femoral shaft, fracture when occurring or inappropriate carrying after wound, sharp-pointed fracture end punctures vascularization massive hemorrhage, add the hemorrhage of fracture itself, the internal hemorrhage amount of adult can reach 500-1500 milliliter, occurs hemorrhagic shock time serious.1/3 fracture under femur, fracture segment is toppled over backward by the tractive of gastrocnemius, and sharp popliteal tremulous pulse, popliteal vein and sciatic nerve can be oppressed or sting to distal fracture end.The damage of blood vessel may cause the blood of far-end of limb for obstacle, even limb necrosis.Sciatic impaired performance is drop foot, toes stretch the classical symptom signs such as unable and foot sensory disturbance in the wrong.Except the situation of above complication, the complication that primary disease all right accompanying infection and bone does not connect etc. is serious.Affect fracture factor: the healing of fracture has been come by osteoblast, so nearly all endogenous and extrinsic factor all may have influence on the metabolism of cell, promote and postpone the healing of fracture.(1) local factor: 1. degree of injury: periosteum injury is serious, the healing rate of fracture is just slower.2. the type of fracture: what fracture was involved is cortical bone or spongy bone, the speed of its healing has obvious difference.Allograft with That of Cancellous is very fast, and the agglutination of cortical bone is complicated, many by external influence factors.3. fixing situation: be fixedly union of fracture essential condition.4. the contact in fracture face: because reduction is bad or fixing improper, make fracture end still have angulation, displacement, separation, these all easily cause nonunion or slow concrescence.5. special violence: when fracture by special violence caused by high-tension electricity or bullet time, cause nonunion or slow concrescence.6. bear a heavy burden too early: irrational early ambulant, make the fiber callus that just formed or osseous callus tear fracture and cause nonunion or slow concrescence.7. broken ends of fractured bone blood is for not enough: the regeneration of tissue, needs enough blood supplys.8. infect: as long as but infection control effectively, fracture to heal.9. pathological fracture: the pathological fracture that osteopathia and tumor cause is under the prerequisite handling local lesion well, and fracture can heal, but malignant tumor often prognosis mala.10. intra-articular fracture: owing to containing plasmin in knuckle synovia, the dissolution of blood clot that it can make fracture early stage after intra-articular fracture, postpone the first phase repair process of fracture, thus healing is slow.(2) systemic factor: the local stress state and the function of current etc. that comprise age, health condition, the impact of hormone, motion and fracture.The malunion of fracture, delayed union, disunion: the malunion that () fractures: malunion of fracture refer to fracture site overlapping, rotate, connect under angulation state and the person that causes limbs disturbance.(2) fracture delayed union and disunion: limbs each portion fracture is through treatment, if after fracture the average healing in the past, when not yet forming bony union, clinical examination still have hinder limb place pain, fracture local still has tenderness and x-ray to take the photograph sheet inspection to see that fracture line is still clear, but fracture end there is no hardening phenomenon person, is fracture delayed union.The method of current treatment fracture of shaft of femur mainly contains non-operative treatment treatment and operative treatment, non-operative treatment also claims expectant treatment, conventional method has: the treatment, acupuncture and moxibustion therapy etc. of various Chinese patent medicine, Western medicine Drug therapy, traction therapeutic, exter-nal fixer, although can be good at relief of symptoms, but therapeutic effect is still undesirable, there is treatment time long, weak curative effect, somewhat expensive and have the defects such as side effect.Western medical treatment fracture of shaft of femur, in recent years, because the improvement of internal fixation device, the raising of surgical technic and people are to the change of fractures idea, fracture of shaft of femur now more is tending towards operative treatment.Fracture operation is treated, except must from fracture position, type, soft tissue injury degree, injure outside the factor considerations such as the systemic conditions of patient with or without merging, also need to select according to two principles: one is the internal fixation material that will have sufficient intensity, make fixing after can early functional exercise and internal fixation apparatus fracture and inefficacy occur before being unlikely to union of fracture; Two is that fracture fixation method will advocate Wicresoft, reduces the destruction of fracture local blood fortune and the internal fixation apparatus stress that do not have as far as possible and concentrates and meet biological fixation principle, to promote union of fracture.The medicament categories limitation for the treatment of fracture of shaft of femur, can not meet the demand of clinical auxiliary treatment.A kind of active drug can treating fracture of shaft of femur of current urgent need, meets the demand of clinical auxiliary treatment.

Doctor trained in Western medicine common drug: calcitriol soft gelatin capsule, razaxaban sheet, Su Shi bone-knitting capsule, salmon calcitonin nasal spray in Chinese etc.Bonesetting, after surgery unsatisfactory curative effect although western medicine therapy can reset in time, treatment time is long, bone healing is slow, patient's muscle power is not easily recovered, and the factors such as long-term bed cause the generation of complication, and therefore the recovery of pharmaceutical preparation to patient of development of new plays irreplaceable effect.

Summary of the invention

Technical problem to be solved by this invention is, a kind of medicine for the treatment of fracture of shaft of femur and preparation method thereof is provided, tool the present invention of the present invention has raw marrow effect with blood tissue regeneration promoting, reunion of bone, blood circulation promoting and blood stasis dispelling and replenishing essence, cure mainly Post operation Fracture of femur in mid-term, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of fracture of shaft of femur, wherein, following raw medicinal material is comprised: Radix Angelicae Sinensis, Ramulus Et Folium Adhatodae Vasicae, Radix Paeoniae Rubra, Radix Toddaliae Asiaticae, Radix Rehmanniae, Radix Rubiae Yunnanensis, Rhizoma Drynariae, Radix Cirsii Japonici, Pyritum, Olibanum, Cortex Lycii, Myrrha, Ramulus Sambuci Williamsii, Lignum Sappan, Herba Asplenii Vaiainte Spleenwort, Caulis Spatholobi, Radix Astragali Preparata, Radix Rubiae, the Cortex Eucommiae, Rhizoma Sparganii, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu and Fructus Hippophae.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12-30 part, Ramulus Et Folium Adhatodae Vasicae 15-40 part, Radix Paeoniae Rubra 15-20 part, Radix Toddaliae Asiaticae 22-43 part, Radix Rehmanniae 12-22 part, Radix Rubiae Yunnanensis 11-33 part, Rhizoma Drynariae 15-25 part, Radix Cirsii Japonici 14-20 part, Pyritum 17-35 part, Olibanum 14-20 part, Cortex Lycii 16-44 part, Myrrha 12-20 part, Ramulus Sambuci Williamsii 14-32 part, Lignum Sappan 13-41 part, Herba Asplenii Vaiainte Spleenwort 15-33 part, Caulis Spatholobi 15-21 part, Radix Astragali Preparata 13-30 part, Radix Rubiae 14-22 part, Cortex Eucommiae 12-30 part, Rhizoma Sparganii 16-43 part, Semen Cuscutae 10-20 part, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 15-30 part, catechu 12-20 part and Fructus Hippophae 18-35 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 30 parts, Ramulus Et Folium Adhatodae Vasicae 25 parts, Radix Paeoniae Rubra 15 parts, Radix Toddaliae Asiaticae 42 parts, Radix Rehmanniae 12 parts, Radix Rubiae Yunnanensis 33 parts, Rhizoma Drynariae 25 parts, Radix Cirsii Japonici 14 parts, Pyritum 31 parts, Olibanum 20 parts, Cortex Lycii 44 parts, Myrrha 14 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 41 parts, Herba Asplenii Vaiainte Spleenwort 32 parts, Caulis Spatholobi 21 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 14 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 15 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 30 parts, 12 parts, catechu and Fructus Hippophae 25 parts.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12 parts, Ramulus Et Folium Adhatodae Vasicae 33 parts, Radix Paeoniae Rubra 18 parts, Radix Toddaliae Asiaticae 22 parts, Radix Rehmanniae 15 parts, Radix Rubiae Yunnanensis 31 parts, Rhizoma Drynariae 25 parts, Radix Cirsii Japonici 16 parts, Pyritum 35 parts, Olibanum 14 parts, Cortex Lycii 42 parts, Myrrha 15 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 40 parts, Herba Asplenii Vaiainte Spleenwort 32 parts, Caulis Spatholobi 20 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 30 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 12 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 24 parts, 12 parts, catechu and Fructus Hippophae 30 parts.

Described medicine also comprises following raw medicinal material: Radix Lamiophlomidis Rotatae, Rhizoma Polygoni Cuspidati, Medulla Sus domestica and Herba Lycopodii Selaginis.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12-30 part, Ramulus Et Folium Adhatodae Vasicae 15-40 part, Radix Paeoniae Rubra 15-20 part, Radix Toddaliae Asiaticae 22-43 part, Radix Rehmanniae 12-22 part, Radix Rubiae Yunnanensis 11-33 part, Rhizoma Drynariae 15-25 part, Radix Cirsii Japonici 14-20 part, Pyritum 17-35 part, Olibanum 14-20 part, Cortex Lycii 16-44 part, Myrrha 12-20 part, Ramulus Sambuci Williamsii 14-32 part, Lignum Sappan 13-41 part, Herba Asplenii Vaiainte Spleenwort 15-33 part, Caulis Spatholobi 15-21 part, Radix Astragali Preparata 13-30 part, Radix Rubiae 14-22 part, Cortex Eucommiae 12-30 part, Rhizoma Sparganii 16-43 part, Semen Cuscutae 10-20 part, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 15-30 part, catechu 12-20 part, Fructus Hippophae 18-35 part, Radix Lamiophlomidis Rotatae 2-3 part, Rhizoma Polygoni Cuspidati 10-25 part, Medulla Sus domestica 15-45 part and Herba Lycopodii Selaginis 13-33 part.

In described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 20 parts, Ramulus Et Folium Adhatodae Vasicae 35 parts, Radix Paeoniae Rubra 15 parts, Radix Toddaliae Asiaticae 42 parts, Radix Rehmanniae 20 parts, Radix Rubiae Yunnanensis 33 parts, Rhizoma Drynariae 22 parts, Radix Cirsii Japonici 14 parts, Pyritum 35 parts, Olibanum 16 parts, Cortex Lycii 44 parts, Myrrha 20 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 40 parts, Herba Asplenii Vaiainte Spleenwort 23 parts, Caulis Spatholobi 15 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 18 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 17 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25 parts, 14 parts, catechu, Fructus Hippophae 35 parts, Radix Lamiophlomidis Rotatae 2 parts, Rhizoma Polygoni Cuspidati 25 parts, Medulla Sus domestica 42 parts and Herba Lycopodii Selaginis 33 parts.

When the dosage form of described medicine is paster agent, it comprises the following steps:

The first step, Myrrha, Ramulus Sambuci Williamsii, Lignum Sappan, Herba Asplenii Vaiainte Spleenwort, Caulis Spatholobi, Radix Astragali Preparata, Radix Rubiae, the Cortex Eucommiae and Rhizoma Sparganii are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu and Fructus Hippophae are mixed in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 ~ 2 times of described medicine each raw medicinal material quality sum, the Colophonium of 1 ~ 2 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.

When the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described medicine is liniment, its preparation method comprises the following steps:

Step one: first described raw medicinal material is ground into coarse powder, then pulverizes further, cross 100 mesh sieves, the enable fine powder amount by 100 mesh sieves at least reaches 40%, collects and obtains fine powder a by the fine powder of 100 mesh sieves;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 8-10 times amount soak by water 1-3 hour, and second time adds weight portion 6-10 times amount soak by water 1-3 hour, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Step 3: call in glycerol after being mixed with fine powder b by fine powder a and make liniment.

The invention has the beneficial effects as follows: the present invention has raw marrow effect with blood tissue regeneration promoting, reunion of bone, blood circulation promoting and blood stasis dispelling and replenishing essence, cure mainly Post operation Fracture of femur in mid-term, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The present invention is to give birth to marrow for primary treatment principle with blood tissue regeneration promoting, reunion of bone, blood circulation promoting and blood stasis dispelling and replenishing essence, cure mainly Post operation Fracture of femur in mid-term, wherein, following raw medicinal material is comprised: Radix Angelicae Sinensis, Ramulus Et Folium Adhatodae Vasicae, Radix Paeoniae Rubra, Radix Toddaliae Asiaticae, Radix Rehmanniae, Radix Rubiae Yunnanensis, Rhizoma Drynariae, Radix Cirsii Japonici, Pyritum, Olibanum, Cortex Lycii, Myrrha, Ramulus Sambuci Williamsii, Lignum Sappan, Herba Asplenii Vaiainte Spleenwort, Caulis Spatholobi, Radix Lamiophlomidis Rotatae, Radix Astragali Preparata, Radix Rubiae, the Cortex Eucommiae, Rhizoma Sparganii, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu, Rhizoma Polygoni Cuspidati, Medulla Sus domestica, Herba Lycopodii Selaginis and Fructus Hippophae.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Herba Lycopodii Selaginis: source: " Shaanxi Chinese herbal medicine ".Source: be the herb of lycopsid goodluck.The whole year can adopt, and dries in the shade or using fresh herb.Nature and flavor: 1. " Shaanxi Chinese herbal medicine ": " mildly bitter flavor, property is put down." 2. " mountain of papers Chinese herbal medicine ": " bitter in the mouth, cool in nature." curing mainly: 1. " Shaanxi Chinese herbal medicine ": " stops blooding, continuous muscle.Control instep and play damage, traumatic hemorrhage." 2. " mountain of papers Chinese herbal medicine ": " loose wind and blood, reducing swelling and alleviating pain.Control traumatic injury, rheumatalgia."

Rhizoma Polygoni Cuspidati: source: " not Lu ".Source: be the rhizome of polygonaceae plant Rhizoma Polygoni Cuspidati.Spring, Qiu Junke excavate, and cut off, dry.Nature and flavor: bitter are flat.1. " not Lu ": " tepor." 2. " property of medicine opinion ": " sweet in the mouth is flat, nontoxic." 3. amplification on Canon of Materia Medica: " micro-hardship." 4. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " is bitter micro-puckery, is slightly cold." 5. " medical center bun is wanted ": " sweetness and bitterness is pungent, temperature." cure mainly: dispel the wind, dampness removing, removing blood stasis with potent drugs, stimulate the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.1. " not Lu ": " main tonneau moon water, broken stagnant blood crux." 2. TAO Hong-Jing: " main sudden and violent abdominal mass, wine stain takes it.It is irritated that " 3. " property of medicine opinion ": " controls large heat, and quench the thirst, diuresis, presses all pyretic toxicity." 4. supplement to the Herbal: " main air is between joint and blood stasis.Liquor takes it as wine." 5. " Japan hanako materia medica ": " manage property after stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI." 6. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " attacks all toxic swellings, and only have sore throat, diuresis, walks meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge." 7. " medical center bun is wanted ": " hard kidney, strong Yang yi Jing, strengthening bone and muscle, increases strength." " is applied to get injured by a fall and is lost place, can reunion of fractured tendons and bones." 8. " south of the Five Ridges gather medicinal herbs record ": " treating snakebite, impetigo, stops loss the pain of injury." 9. " Guizhou side's medicine among the people collection ": " astringing to arrest bleeding, control hemorrhoid complicated by anal fistula, curing rheumatism, deliver cold expelling, dissipating blood stasis blood, burn is controlled in external." 10. " experiment of TCM research ": " controls excess-fire toothache, and the rotten lower limb of eczema, toe discrimination wets rotten."

Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati): source: " the SHENGCAO property of medicine is standby to be wanted ".Nature and flavor: Gan Xin are cool.1. " book on Chinese herbal medicine asks former ": " light pungent, flat." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " is sweet light, cool." cure mainly: liver heat removing, invigorate blood circulation, pain relieving.Control hypertension, menoxenia, injured bone, skin infection.1. " the SHENGCAO property of medicine is standby to be wanted ": " disappear skin ulcer, and pus of tut-tuting, dispels the wind, pain relieving, reason phlegm-fire." 2. " Guangxi Chinese medicinal herbal ": " dissipating blood stasis, continuous muscle, synthetism, pain relieving.Control injured." 3. Guangzhou army " conventional Chinese herbal medicine handbook ": " removing heat from the liver to lower the high blood pressure, promoting blood circulation to remove blood stasis."

Rhizoma Sparganii: source: supplement to the Herbal.Nature and flavor: toil are flat.1. supplement to the Herbal: " sweet flat, temperature." 2. " Japan hanako materia medica ": " sweet-puckery flavor is cool." 3. " Kaibao Bencao ": " bitter in the mouth is flat, nontoxic." 4. " Amplification on Materia Medica addendum ": " works hard." return through: enter liver.Spleen channel.1. " Thunder God process of preparing Chinese medicine property of medicine solution " > Thunder God concocts property of medicine solution ": " enter lung, spleen two warp." 2. " Bencao Jingshu ": " enters foot and faints cloudy, lunar." cure mainly: removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Control lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.1. " Japan hanako materia medica ": " control married woman's blood vessels uncomfortable, cardiac and abdominal pain, fall tire, and disappear stagnant blood, mends labor, and logical menstruation, controls flatulence, disappear and flutter damage blood stasis, puerperal abdonimal pain, blood fortune stagnated blood not under." 2. " Kaibao Bencao ": " main old addiction lump in the abdomen caking." 3. " medicine origin ": " main heart diaphragmodynia, diet does not disappear, dispelling the stagnated QI." 4. Wang Haogu: " leads to Liver Channel hematocele.Controlling skin ulcer swells hard."

Radix Rubiae: source: be the root welding technology of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Spring, autumn excavate, and removing silt, dries.Nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Cure mainly: removing heat from blood and promoting blood circulation, blood stasis dispelling, stimulate the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.Join Os Sepiae hemostasis power stronger.

Radix Lamiophlomidis Rotatae: nature and flavor: bitter, is slightly cold.Slightly poisonous.Cure mainly: blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For traumatic injury, fracture, lumbar strain.

Herba Asplenii Vaiainte Spleenwort: another name: variation Asplenium trchomanes L., ferrum wolf beanstalk.Source: fern Aspleniaceae Herba Asplenii Vaiainte Spleenwort Asplenium varians Wall., with all herbal medicine.Nature and flavor: micro-puckery, cool.Cure mainly: hemostasis, granulation promoting.Cure mainly knife injury fracture.

Ramulus Sambuci Williamsii: another name: justice is old, pubescent angelica root, horse urine are disturbed, Radix seu folium Gaultheriae intermediae [Shaanxi].Source: Caprifoliaceae Sambucus plant Ramulus Sambuci Williamsii Sambucus williamsii Hance, is used as medicine with Herb.Xia Qiu gathers, and dries.Nature and flavor: sweet, bitter are flat.Gui Jing: return Liver Channel.Cure mainly: reunion of bone, promoting blood circulation and stopping pain, expelling wind and removing dampness.For fracture, traumatic injury, rheumatic arthritis, gout, Kaschin-Beck disease, acute and chronic nephritis; Wound hemorrhage is controlled in external.

Cortex Lycii: source: " herbal classic ".Nature and flavor: sweet, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " Great Cold, nontoxic." 3. " detailed outline ": " slightly sweet flavor, cold." return through: enter lung, liver, kidney channel.Cure mainly: heat clearing away, removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, quenches one's thirst, hypertension, carbuncle, malignant boil.1. " herbal classic ": " pathogen in main five, hankers quenching one's thirst, general arthralgia." 2. " not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat." 3. " property of medicine opinion ": " smooth file, face is mixed and is well-donely gulped down it, cures mainly kidney family tradition." 4. " Treatise on Dietetic Therapy ": " heat of boning is quenched one's thirst." 5. " book on Chinese herbal medicine is not mentionleted alone ": " controls incised wound." 6. Li Gao: " controls at table without fixed ailment said due to cold or exposure, passes the hectic fever due to YIN-deficiency that corpse has antiperspirant." 7. Wang Haogu: " rushes down kidney fire, falls the lung fire second of the three ten-day periods of the hot season, removes born of the same parents' moderate heat, bring down a fever, correction gas." 8. " daily book on Chinese herbal medicine ": " is controlled postcibal vomiting and is spitted blood; Decoct soup to gargle, only tooth blood, controls the osteomyelitis of the maxillary bone." 9. " detailed outline ": " goes part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney deficiency-heat." 10. " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternate attacks of chills and fever, allly sees blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine."

Radix Cirsii Japonici: source: this product is dry aerial parts or the root of feverfew Ji Cirsium japonicum DC..Summer, autumn two tap aerial parts when season, the flowers are in blossom, or autumn end uproots, and removing impurity, dries.Nature and flavor: sweet are bitter, cool.Gui Jing: GUIXIN, Liver Channel.Cure mainly: cooling blood for hemostasis, removing blood stasis to reduce swelling.For epistaxis, spit blood, hematuria, has blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.

Radix Rubiae Yunnanensis: source: Lamiaceae Salvia platymiscium threeleaf Mus tail Salvia trijuga Diels, is used as medicine with root.Spring and autumn adopts root, and summer dries.Nature and flavor: bitter, sweet, temperature.Cure mainly: regulating menstruation and activating blood, promoting tissue regeneration by removing blood stasis.For menoxenia, dysmenorrhea, blood deficiency amenorrhea, lumbago due to renal deficiency.

Radix Toddaliae Asiaticae: another name: Radix Zanthoxyli Spinifolii, rescue greatly, Sedum aizoon L., Radix Phytolaccae, le hook, yellow great Jin root.Source: be Rutaceae Radix Toddaliae Asiaticae platymiscium Radix Toddaliae Asiaticae Toddalia asiatica(L.) Lam. [T. aculeata Pers.], is used as medicine with root or leaf.Summer, autumn picking leaves; Root can be adopted the whole year, clean dry for subsequent use.Nature and flavor: pungent, micro-hardship, temperature.Cure mainly: dissipating blood stasis stops blooding, expelling wind and removing dampness, subduing swelling and detoxicating.Root bark: traumatic injury, rheumatic arthritis, intercostal neuralgia, stomachache, menoxenia, dysmenorrhea, amenorrhea; Fracture is controlled in external, traumatic hemorrhage.Leaf: carbuncle furuncle and phyma poison is controlled in external, venom.

Ramulus Et Folium Adhatodae Vasicae: source: " Guangxi Chinese medicinal herbal ".Another name: Paraboea dictyoneura (Hance) B. L (Burtt) (" Guangzhou flora "), tap grass (" register planted by Guangxi medicine "), Ramulus Et Folium Adhatodae Vasicae disappears, Ramulus Et Folium Adhatodae Ventricosea, Ramulus Et Folium Adhatodae Vasicae, Ramulus Sambuci Williamsii, greatly osteomiosis, greatly Herba Equiseti Palustris, DAJIEGU (" Guangxi Chinese herbal medicine ").Source: be the branch and leaf of acanthaceous plant Adhatoda vasica Nees.The whole year can adopt, and dries or using fresh herb.Nature and flavor: pungent, temperature.1. " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature, nontoxic." 2. " Guangxi Chinese herbal medicine ": " taste is micro-misery, and property is put down, nontoxic." cure mainly: promoting blood circulation to remove blood stasis.Dispelling the wind and dampness pathogens arthralgia pain, traumatic injury blood stasis swells and ache, menoxenia.1. " Guangzhou flora ": " Herb: can expectorant and control woman's menorrhagia disease." 2. the western Chinese medicinal herbal in ore deposit ": " restore menstrual flow and invigorate blood circulation, removing blood stasis to promote tissue regeneration, alleviating pain and detumescence, continuous wound absolutely.Control injury and bone fracture, blood stasis swells and ache, rheumatic arthralgia."

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Radix Paeoniae Rubra: bitter, is slightly cold.Return Liver Channel.Nourishing yin and purging fire, removing heat from blood and promoting blood circulation." property of medicine opinion ": " control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, control evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus." energy blood stasis removing, pain relieving, removing heat from blood, detumescence.Can be used for controlling the stagnant amenorrhea of the stasis of blood, hernia abdominal mass is gathered, stomachache, hypochondriac pain, epistaxis, dysentery, discharging fresh blood stool, conjunctival congestion, carbuncle.

Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel.Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly folding to fall, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fill out bone marrow, longue meat.Make soup except cold and heat and gather, eliminating impediment.Survivor is especially good." heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, removing heat from blood, hemostasis invigorate blood circulation.Radix Rehmanniae is cold in nature, and function is heat clearing and blood cooling, enriching yin and nourishing kidney, promoting the production of body fluid to quench thirst, is usually used in the diseases such as treatment hectic fever due to YIN-deficiency consumptive disease heat, throat pain, sputum mixed with blood.

Rhizoma Drynariae: bitter, temperature; Return kidney, Liver Channel.The kidney invigorating bone strengthening, continues and hinders pain relieving." property of medicine opinion ": " five kinds of over strain six types of severe debility disease, mouth (one do ' foot ') hands is not received, upper heat and lower cold for poison in main bone, wind blood pain." " Japan hanako materia medica ": " controls malignant boil, loses rotten meat, parasite killing." " book on Chinese herbal medicine is looked for the truth ": " Rhizoma Drynariae, though similar to Fructus Psoraleae, so always specially to reinforce the kidney the logical heart not as Fructus Psoraleae, and controlling also without removing blood stasis removing blood stasis." the kidney invigorating bone strengthening continues and hinders pain relieving.For lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, injured bone; External treatment alopecia areata, vitiligo.

Pyritum: nature and flavor: pungent is flat.Gui Jing: return Liver Channel.Cure mainly: dissipating blood stasis, synthetism, pain relieving.For tumbling and swelling, injured bone Radix Dipsaci: another name: Radix Dipsaci, shaven head, chervil.Nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, kidney channel.Cure mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.

Olibanum: pungent, bitter, temperature.Enter the heart, liver, spleen channel.Removing stasis to stop bleeding, promoting blood circulation and stopping pain granulation promoting.Supplement to the Herbal: " treat deaf, apoplexy locked mouth, married woman's vim and vigour, can send out wine, manage air-cooled, and only large intestine lets out Bleach, treats all skin ulcers and makes internal diabetes." Compendium of Material Medica: " all poison of eliminating carbuncle cellulitis, the heart is protected in Tuoli, and analgesic therapy of invigorating blood circulation, stretches muscle, controls married woman's difficult labour, injured." regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.

Myrrha: another name: myrrh, bright Myrrha.Source: the oleo-gum-resin that Burseraceae bdellium plant myrrh Commiphora myrrha Engl. [C. molmol Engl.] and the trunk skin zone belonging to his kind of plant together ooze out.Generally gather between February November to next year, but also have and gather between 6 ~ July, pick clean bark and other impurity after gathering and get final product.Nature and flavor: bitter are flat.Cure mainly: eliminating stasis to stop pain, externally used detumescence granulation promoting.Swell and ache for traumatic injury congestion, ulcer sore pain, all pains of breast abdomen; External is controlled the open sore part and is not restrained for a long time.

Lignum Sappan: sweet, salty, pungent, cool; The heart, liver, stomach, spleen channel.Blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain.

Caulis Spatholobi: nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Can relaxing muscles and tendons to promote blood circulation, blood regulating menstruation.Main numb hand and foot; Quadriplegia; Rheumatic arthralgia; Women has through uncomfortable; Dysmenorrhea; Amenorrhea.Function: enrich blood, invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.This product is containing formoononetin, ononin, prunusetin., A Fuluomoxin, cajinin, licochalcone, isoliquiritigenin, tetrahydroxy chalcone derivative, Daidezin, 7-hydroxy-11,12-(methylenedioxy)coumestan, 9-O-methoxyl group coumestrol, 3,7-dihydroxy-6-melonia flavonol, epicatechin, protocatechuic acid, freidelin-3b-alcohol, b-sitosterol, daucosterol and 7-ketone group-b-sitosterol.

Radix Astragali Preparata: sweet, tepor; Return lung, spleen, liver, kidney channel.Air making-up and spleen enlivening, benefit defends real table, ascending up spleen-Qi and Yang, poison holding sore, inducing diuresis to remove edema.Essentials of Matea Medica: " Radix Astragali, life consolidating superficial resistance losslessly can be sent out, and have antiperspirant to stop; Process with invigorating middle warmer, beneficial vigour, strong taste.Hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Variola does not rise, and yang deficiency should it without hot person." " book on Chinese herbal medicine justice ": " replenishing vital QI with drugs of warm nature taste, all middle gas is depressed, and spleen soil is weak, and the person of sinking is the most suitable for clearing heat in QI system for the Radix Astragali, soil in tonification.Its skin goes directly the skin table muscle of people, and solid protection defends sun, and enriching table point, is its speciality, so all diseases of exterior deficiency, and the most refreshing agent." function consolidating superficial resistance arresting sweating, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, regulating fluid apssage.The Radix Astragali makes contractile ability strengthen, and can improve the blood circulation of whole body, can coronary artery dilator, Renal vascular and Rhizoma Bistortae peripheral vessel, make cutaneous circulation vigorous; The nonspecific immunity power of body can be improved, protect the liver and fall hypoglycemic effect, have inhibitory action to staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, dysentery bacterium etc.The Radix Astragali can appreciable impact splenocyte Information Conduction, realizes immunoregulation effect.Can be used for hypertension, ischemic heart desease, acute glomerulonephritis, gastric ulcer, psoriasis, diabetes, osteoporosis.

The Cortex Eucommiae: another name: pull a skin, think the second month in a season, silk flosssilk wadding skin, beautiful silk skin.Source: this product is the dry bark of Eucommiaceae plant Cortex Eucommiae Eucommia ulmoides Oliv..4 ~ June strips, and scrapes off rough bark, and " diaphoresis " to endothelium of banking up is puce, dries.Nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.

Semen Cuscutae: abnormal smells from the patient is pungent, sweet, flat, nontoxic.The kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion." not Lu ": " support flesh reinforcing YIN-essence, hard muscles and bones, stem invasion by pathogenic cold, essence is from going out, and drown and have the heeltap, bitter taste is yearningly dry, and cold blood is long-pending." " Japan hanako materia medica ": " mends five kinds of strain and seven kinds of impairment, controls and lets out essence, hematuria, profit cardiopulmonary." the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity.The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, impotence and seminal emission, crazy talk, frequent micturition, dripping urination, dizziness and blurred vision, blurring of vision, Hiccough and deaf and women's leukorrhagia, habitual abortion.

Catechu: bitter in the mouth, puckery, cold nature, returns lung meridian, has effect of removing dampness promoting tissue regeneration and ulcer healing, and for ulcer being unable to heal, eczema, aphtha, falls and flutter the pain of injury, the cards such as traumatic hemorrhage.Contained by these product, d-cachou extract and epicatechin all have remarkable hepatoprotective effect.When existing without antigen, d-cachou extract does not affect leukoplania, but in vitro tests suppresses the migration to the normal human leukocytes of protein derivatives (PPD) antigen sensitive of purification, and to once infecting hepatitis B and it is stronger to the inhibitory action of leukoplania to the patient of hepatitis B surface antigen sensitivity, show its can magnocell mediation immunoreation and promote the removing of hepatitis B antigen.Catechu water liquid gavages, and can suppress duodenum in rabbit and intestinal motility on an empty stomach, promote caecum retrostalsis, but have no significant effect colon.

Medulla Sus domestica: source: " detailed outline ".Source: be spinal cord or the bone marrow of porcine animals pig.Nature and flavor: sweet, cold.1. " Bencao Tujing ": severe cold." 2. " detailed outline ": " is sweet, cold. and nontoxic." 3. " occupying diet spectrum with breath ": " is sweet, flat." cure mainly: nourishing YIN benefit marrow.Control hectic fever due to YIN-deficiency consumptive fever, quench one's thirst, skin infection.1. " Bencao Tujing ": " master flutters damage malignant boil." 2. " detailed outline ": " is coated with that children's infantile metopism, head sore and umbilicus are swollen, eyebrow skin ulcer, the Psoralen marrow of clothes, beneficial asthenia." 3. " occupying diet spectrum with breath ": " mends marrow yin nourishing, and control hectic fever due to YIN-deficiency consumptive fever, foul leukorrhea is passed out semen, and is preferably the food of aging.The cards such as " 4. " book on Chinese herbal medicine is just read ": " all deficiency of YIN hectic fever due to YIN-deficiency, five heart fever at night, rachiagia ridge are convex, all can use it.

Fructus Hippophae: another name: fructus hippophae, vinegar thorn willow, acid thorn, black thorn, vinegar willow.Source: this strain Mongols, Tibetan's conventional crude drugs.For the dry mature fruit of Elaeangnaceae hippophae plant Fructus Hippophae Hippophae rhamnoides L..Autumn, season in winter two fruit maturation or adfreezing time gather, removing impurity, dry or dry after steaming.Nature and flavor: sour, puckery, temperature.Cure mainly: eliminating phlegm and stopping cough, relieving dyspepsia, promoting blood circulation to remove blood stasis.For cough with copious phlegm, dyspepsia, abdominal pain due to retention of food, blood stasis amenorrhea, falls and flutters congestive edema.

The agent of embodiment 1 paster

The manufacturing process of paster agent of the present invention is: get Radix Angelicae Sinensis 200g, Ramulus Et Folium Adhatodae Vasicae 350g, Radix Paeoniae Rubra 150g, Radix Toddaliae Asiaticae 420g, Radix Rehmanniae 200g, Radix Rubiae Yunnanensis 330g, Rhizoma Drynariae 220g, Radix Cirsii Japonici 140g, Pyritum 350g, Olibanum 160g, Cortex Lycii 440g, Myrrha 200g, Ramulus Sambuci Williamsii 300g, Lignum Sappan 400g, Herba Asplenii Vaiainte Spleenwort 230g, Caulis Spatholobi 150g, Radix Astragali Preparata 300g, Radix Rubiae 220g, Cortex Eucommiae 180g, Rhizoma Sparganii 420g, Semen Cuscutae 170g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 250g, catechu 140g, Fructus Hippophae 350g, Radix Lamiophlomidis Rotatae 20g, Rhizoma Polygoni Cuspidati 250g, Medulla Sus domestica 420g and Herba Lycopodii Selaginis 330g,

The first step, Myrrha, Ramulus Sambuci Williamsii, Lignum Sappan, Herba Asplenii Vaiainte Spleenwort, Caulis Spatholobi, Radix Astragali Preparata, Radix Rubiae, the Cortex Eucommiae and Rhizoma Sparganii are mixed in described ratio, with the dissolve with ethanol of the determining alcohol 85% of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 95% of 2 times relative to the mixture quality obtained, reflux was extracted after 1.5 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;

Second step, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu and Fructus Hippophae are mixed in described ratio, add and extract 2 times relative to the alcohol heating reflux of the determining alcohol 90% of 3 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the mastic of 1.22, and the mastic spray dryer after concentrated is dried to powder;

3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 4 hours, filters; By filtering residue again with the water dissolution of 2 times relative to the mixture quality obtained, heating decoction 2 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

4th step, the powder mixing first step, second step and the 3rd step obtained, adds relative to the rubber of 1 times of described medicine each raw medicinal material quality sum, the Colophonium of 1.5 times, mixing, make coating, carry out painting cream, cut off, lid lining, section, namely obtains described paster agent.

Embodiment 2 tablet

The manufacturing process of Tablets is: get Radix Angelicae Sinensis 300g, Ramulus Et Folium Adhatodae Vasicae 250g, Radix Paeoniae Rubra 150g, Radix Toddaliae Asiaticae 420g, Radix Rehmanniae 120g, Radix Rubiae Yunnanensis 330g, Rhizoma Drynariae 250g, Radix Cirsii Japonici 140g, Pyritum 310g, Olibanum 200g, Cortex Lycii 440g, Myrrha 140g, Ramulus Sambuci Williamsii 300g, Lignum Sappan 410g, Herba Asplenii Vaiainte Spleenwort 320g, Caulis Spatholobi 210g, Radix Astragali Preparata 300g, Radix Rubiae 220g, Cortex Eucommiae 140g, Rhizoma Sparganii 420g, Semen Cuscutae 150g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 300g, catechu 120g and Fructus Hippophae 250g;

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 90%, reflux 5 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 450 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.15 times, 0.25 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.04 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 3 liniment

The manufacturing process of liniment of the present invention is: get Radix Angelicae Sinensis 120g, Ramulus Et Folium Adhatodae Vasicae 330g, Radix Paeoniae Rubra 180g, Radix Toddaliae Asiaticae 220g, Radix Rehmanniae 150g, Radix Rubiae Yunnanensis 310g, Rhizoma Drynariae 250g, Radix Cirsii Japonici 160g, Pyritum 350g, Olibanum 140g, Cortex Lycii 420g, Myrrha 150g, Ramulus Sambuci Williamsii 300g, Lignum Sappan 400g, Herba Asplenii Vaiainte Spleenwort 320g, Caulis Spatholobi 200g, Radix Astragali Preparata 300g, Radix Rubiae 220g, Cortex Eucommiae 300g, Rhizoma Sparganii 420g, Semen Cuscutae 120g, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 240g, catechu 120g and Fructus Hippophae 300g;

Step 2: the coarse powder not by 100 mesh sieves is dropped into multi-function extractor and extracts twice, first time adds weight portion 9 times amount soak by water 2 hours, and second time adds weight portion 7 times amount soak by water 3 hours, merges twice decocting liquid, filters to get filtrate; The heating of gained filtrate is concentrated into pasty state, and after putting into the oven dry of 80 DEG C, baking oven, room temperature cools, and grinds to form fine powder b;

Acute skin irritation test: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, the paster agent prepared by embodiments of the invention 1 to be directly attached on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 2 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage medicine of the present invention is 901 times of quantity.Therefore the sheet acute toxicity of the embodiment of the present invention 2 is low, clinical drug safety.

Long term toxicity test: the tablet of the embodiment of the present invention 2 presses 10.78,20.35 and 33.48g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that the tablet of the embodiment of the present invention 2 is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch the 308 routine Patients with Bone Fractures coming from the court's orthopaedics patient, male 171 people, female 137 people; Left side 133 example, right side 101 example, bilateral 74 example.Age 18-77 year.Injured reason: traffic accident 93 example, traumatic injury 87 example, injures 77 examples by a crashing object, other reason 51 example.Classification of fracture: comminuted 91 examples, oblique 83 examples, spiral type 75 example, horizontal shape 59 example.308 routine patients, all through operative treatment, are postoperatively divided into patch treatment group, tablet in treatment group, liniment treatment group and matched group, each experimental group 77 people by 308 routine patients at random, wherein, and paster agent treatment group: 77 people, male 43 people, female 34 people; Left side 33 example, right side 26 example, bilateral 18 example.Tablet in treatment group: 77 people, male 41 people, female 36 people; Left side 33 example, right side 25 example, bilateral 19 example.Liniment treatment group: 77 people, male 44 people, female 33 people; Left side 34 example, right side 24 example, bilateral 19 example.Matched group: 77 people, male 43 people, female 34 people; Left side 33 example, right side 26 example, bilateral 18 example.

Diagnostic criteria:

1, patient has clear and definite trauma history.

2, thigh local pain is relatively more violent, and the angulation of visible thigh, shortening deformity, fracture site often has abnormal movement.

3, positive position, side X line sheet display fracture site, type and direction of displacement.

4, suspect there is blood vessel injury, should row B type ultrasonic examination or angiography.

5, injury of sciatic nerve person's row Neuro electromyograph.

Therapeutic Method:

Paster agent treatment group: use paster agent prepared by the embodiment of the present invention 1,2 times on the one, every 7 days is a course for the treatment of;

Tablet in treatment group: use the embodiment of the present invention 2 prepare tablet, 2 times on the one, one time 2, every 7 days is a course for the treatment of;

Liniment treatment group: use liniment prepared by the embodiment of the present invention 3,2 times on the one, every 7 days is a course for the treatment of; Matched group: oral GUZHE CUOSHANG JIAONANG, 3 times on the one, one time 4 ~ 6, every 7 days is a course for the treatment of.

Fracture of shaft of femur efficacy assessment standard: excellent: within suffering limb cripetura 0.5cm, hip, knee joint are stretched and are in the wrongly respectively differed within 15 °, X ray examination anatomical reduction or nearly anatomical reduction.Angulation is person's (namely this physiologic radian differs within 5 °) within 15 °.Good: suffering limb shortens 0.6-1cm, hip, knee joint are stretched and are in the wrongly respectively differed from 1 °-30 °, and do not hinder life and work, within X ray examination fracture overlapping 1cm, angulation is 16 ° of-20 ° of persons.Shang Ke: suffering limb shortens within 1.1-2cm, hip, knee joint are stretched and are in the wrongly respectively differed from 31 °-45 °, and X ray examination fracture overlapping 1.1-2cm, angulation is 21 ° of-25 ° of persons.Difference: fail to reach above-mentioned requirements person.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy fracture of shaft of femur of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy fracture of shaft of femur of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Excellent	Good	Shang Ke	Difference	Total effective rate (%)
							Paster agent treatment group	77	74	3	0	0	100％
Tablet in treatment group	77	72	4	1	0	98.7％
							Liniment treatment group	77	73	3	1	0	98.7％
Matched group	77	55	14	5	3	89.6％

Table 2 Four composition is excellent and good several time comparative example (%) after not treating 4 courses for the treatment of

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Paster agent treatment group	77	17（22.1％）	19（24.7％）	20（26％）	21（27.3％）
Tablet in treatment group	76	15（19.7％）	19（25％）	21（27.6％）	21（27.6％）
						Liniment treatment group	76	16（21.1％）	19（25％）	20（26.3％）	21（27.6％）
Matched group	69	7（10.1％）	10（14.5％）	14（20.3％）	38（55.1％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; 229 examples of excellent to treatment group in my good man number and the excellent and good 69 routine follow-up of patients 1 year half of matched group simultaneously, result is added up, and in paster agent treatment group 77 example, excellent 74 examples and good 3 examples are all without recurring, and relapse rate is 0%; In tablet in treatment group 76 example, excellent 72 examples are without recurrence, 1 case relapsed in good 4 examples, and relapse rate is 1.3%; In liniment treatment group 76 example, excellent 73 examples are without recurrence, 1 case relapsed in good 3 examples, and relapse rate is 1.3%; Matched group is excellent and my good man's number 69 routine, recurs 7 examples in excellent 55 routine patients, recurs 9 examples, relapse rate 23.2% in good 14 routine patients; Above-mentioned recurrence refer to patient outcomes reach excellent or good after, in 1 year half of following up a case by regular visits to, obviously there is the symptom before treatment.

Model case: Wang, male, falls for 53 years old, shows through the inspection of X sheet: hypomere fracture in fl, and the broken ends of fractured bone misplaces, and does not give special handling, and patient goes home recuperation, but left thigh pain is without alleviation, slightly touches that the pain increased, and left lower extremity can not walking with load.Outpatient service doctor intends after health check-up and diagosis " in fl hypomere fracture ", and income is in hospital and is treated further.Since injured, spirit fair, receive can, difference of sleeping night, two just self-regulateds.Give row manual reduction and left tibia tuberosity traction therapy of bone after being admitted to hospital, and coordinate left thigh clamping plate External fixation, take the tablet of Medications Example 2 of the present invention simultaneously, 2 times on the one, one time 2, treat and substantially cure for 1 month, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of fracture of shaft of femur for one kind, it is characterized in that, comprise following raw medicinal material: Radix Angelicae Sinensis, Ramulus Et Folium Adhatodae Vasicae, Radix Paeoniae Rubra, Radix Toddaliae Asiaticae, Radix Rehmanniae, Radix Rubiae Yunnanensis, Rhizoma Drynariae, Radix Cirsii Japonici, Pyritum, Olibanum, Cortex Lycii, Myrrha, Ramulus Sambuci Williamsii, Lignum Sappan, Herba Asplenii Vaiainte Spleenwort, Caulis Spatholobi, Radix Astragali Preparata, Radix Rubiae, the Cortex Eucommiae, Rhizoma Sparganii, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu and Fructus Hippophae.

2. the medicine for the treatment of fracture of shaft of femur according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12-30 part, Ramulus Et Folium Adhatodae Vasicae 15-40 part, Radix Paeoniae Rubra 15-20 part, Radix Toddaliae Asiaticae 22-43 part, Radix Rehmanniae 12-22 part, Radix Rubiae Yunnanensis 11-33 part, Rhizoma Drynariae 15-25 part, Radix Cirsii Japonici 14-20 part, Pyritum 17-35 part, Olibanum 14-20 part, Cortex Lycii 16-44 part, Myrrha 12-20 part, Ramulus Sambuci Williamsii 14-32 part, Lignum Sappan 13-41 part, Herba Asplenii Vaiainte Spleenwort 15-33 part, Caulis Spatholobi 15-21 part, Radix Astragali Preparata 13-30 part, Radix Rubiae 14-22 part, Cortex Eucommiae 12-30 part, Rhizoma Sparganii 16-43 part, Semen Cuscutae 10-20 part, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 15-30 part, catechu 12-20 part and Fructus Hippophae 18-35 part.

3. the medicine for the treatment of fracture of shaft of femur according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 30 parts, Ramulus Et Folium Adhatodae Vasicae 25 parts, Radix Paeoniae Rubra 15 parts, Radix Toddaliae Asiaticae 42 parts, Radix Rehmanniae 12 parts, Radix Rubiae Yunnanensis 33 parts, Rhizoma Drynariae 25 parts, Radix Cirsii Japonici 14 parts, Pyritum 31 parts, Olibanum 20 parts, Cortex Lycii 44 parts, Myrrha 14 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 41 parts, Herba Asplenii Vaiainte Spleenwort 32 parts, Caulis Spatholobi 21 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 14 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 15 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 30 parts, 12 parts, catechu and Fructus Hippophae 25 parts.

4. the medicine of the treatment fracture of shaft of femur according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12 parts, Ramulus Et Folium Adhatodae Vasicae 33 parts, Radix Paeoniae Rubra 18 parts, Radix Toddaliae Asiaticae 22 parts, Radix Rehmanniae 15 parts, Radix Rubiae Yunnanensis 31 parts, Rhizoma Drynariae 25 parts, Radix Cirsii Japonici 16 parts, Pyritum 35 parts, Olibanum 14 parts, Cortex Lycii 42 parts, Myrrha 15 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 40 parts, Herba Asplenii Vaiainte Spleenwort 32 parts, Caulis Spatholobi 20 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 30 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 12 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 24 parts, 12 parts, catechu and Fructus Hippophae 30 parts.

5. the medicine of the treatment fracture of shaft of femur according to any one of claim 1-4, is characterized in that, described medicine also comprises following raw medicinal material: Radix Lamiophlomidis Rotatae, Rhizoma Polygoni Cuspidati, Medulla Sus domestica and Herba Lycopodii Selaginis.

6. the medicine of the treatment fracture of shaft of femur according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 12-30 part, Ramulus Et Folium Adhatodae Vasicae 15-40 part, Radix Paeoniae Rubra 15-20 part, Radix Toddaliae Asiaticae 22-43 part, Radix Rehmanniae 12-22 part, Radix Rubiae Yunnanensis 11-33 part, Rhizoma Drynariae 15-25 part, Radix Cirsii Japonici 14-20 part, Pyritum 17-35 part, Olibanum 14-20 part, Cortex Lycii 16-44 part, Myrrha 12-20 part, Ramulus Sambuci Williamsii 14-32 part, Lignum Sappan 13-41 part, Herba Asplenii Vaiainte Spleenwort 15-33 part, Caulis Spatholobi 15-21 part, Radix Astragali Preparata 13-30 part, Radix Rubiae 14-22 part, Cortex Eucommiae 12-30 part, Rhizoma Sparganii 16-43 part, Semen Cuscutae 10-20 part, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 15-30 part, catechu 12-20 part, Fructus Hippophae 18-35 part, Radix Lamiophlomidis Rotatae 2-3 part, Rhizoma Polygoni Cuspidati 10-25 part, Medulla Sus domestica 15-45 part and Herba Lycopodii Selaginis 13-33 part.

7. the medicine of the treatment fracture of shaft of femur according to any one of claim 1-6, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Radix Angelicae Sinensis 20 parts, Ramulus Et Folium Adhatodae Vasicae 35 parts, Radix Paeoniae Rubra 15 parts, Radix Toddaliae Asiaticae 42 parts, Radix Rehmanniae 20 parts, Radix Rubiae Yunnanensis 33 parts, Rhizoma Drynariae 22 parts, Radix Cirsii Japonici 14 parts, Pyritum 35 parts, Olibanum 16 parts, Cortex Lycii 44 parts, Myrrha 20 parts, Ramulus Sambuci Williamsii 30 parts, Lignum Sappan 40 parts, Herba Asplenii Vaiainte Spleenwort 23 parts, Caulis Spatholobi 15 parts, Radix Astragali Preparata 30 parts, 22 parts, Radix Rubiae, the Cortex Eucommiae 18 parts, Rhizoma Sparganii 42 parts, Semen Cuscutae 17 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 25 parts, 14 parts, catechu, Fructus Hippophae 35 parts, Radix Lamiophlomidis Rotatae 2 parts, Rhizoma Polygoni Cuspidati 25 parts, Medulla Sus domestica 42 parts and Herba Lycopodii Selaginis 33 parts.

8. the preparation method of the medicine of the treatment fracture of shaft of femur according to any one of claim 1-7, is characterized in that, when the dosage form of described medicine is paster agent, it comprises the following steps:

Second step, Semen Cuscutae, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati), catechu and Fructus Hippophae are mixed in described ratio, add and extract 1 ~ 2 time relative to the alcohol heating reflux of the determining alcohol 85% ~ 95% of 2 ~ 4 times of the mixture quality obtained, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder; 3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, heating decoction 1 ~ 2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;

9. the preparation method of the medicine of the treatment fracture of shaft of femur according to any one of claim 1-7, is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

10. the preparation method of the medicine of the treatment fracture of shaft of femur according to any one of claim 1-7, is characterized in that, when the dosage form of described medicine is liniment, its preparation method comprises the following steps: