WO2021208335A1 - Composition de médecine traditionnelle chinoise capable d'éliminer les toxines, de supprimer la moiteur, et de décongestionner la gorge, et son application - Google Patents

Composition de médecine traditionnelle chinoise capable d'éliminer les toxines, de supprimer la moiteur, et de décongestionner la gorge, et son application Download PDF

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Publication number
WO2021208335A1
WO2021208335A1 PCT/CN2020/113274 CN2020113274W WO2021208335A1 WO 2021208335 A1 WO2021208335 A1 WO 2021208335A1 CN 2020113274 W CN2020113274 W CN 2020113274W WO 2021208335 A1 WO2021208335 A1 WO 2021208335A1
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parts
dampness
detoxification
traditional chinese
chinese medicine
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PCT/CN2020/113274
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English (en)
Chinese (zh)
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张忠德
邹旭
金连顺
唐丽娟
王媛媛
刘云涛
奚小土
丁邦晗
杨荣源
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广东省中医院
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Publication of WO2021208335A1 publication Critical patent/WO2021208335A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535—Perilla (beefsteak plant)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/808—Scrophularia (figwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Definitions

  • the invention belongs to the technical field of traditional Chinese medicine, and relates to a traditional Chinese medicine composition for detoxification, dampness, and pharyngeal relief and its application.
  • Coronavirus pneumonia (Corona Virus Disease 2019, COVID-19), referred to as “new coronary pneumonia”, is pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2) infection.
  • SARS-CoV-2 asymptomatic infections asymptomatic infections of the new crown virus
  • asymptomatic infections are highly contagious.
  • asymptomatic infections are highly contagious.
  • screening and drug intervention for asymptomatic infections are very important and urgent.
  • a traditional Chinese medicine composition for detoxification, dampness and pharyngeal relieving comprising the following components in parts by mass: 15-35 parts of raw coix seed, 10-15 parts of honeysuckle, 10-15 parts of sesame leaves, 10-30 parts of Scrophulariaceae, 10-20 parts of Platycodon grandiflorum, 15-30 parts of Radix Atractylodes, 5-15 parts of Atractylodes, 5-15 parts of Huoxiang.
  • the raw coix seed clears away heat and invigorates the spleen and oozes dampness, and Huoxiang fragrant to transform turbidity.
  • the two are the master medicine, which can remove dampness and detoxify.
  • Honeysuckle and Atractylodes are the main medicines. Honeysuckle clears away heat and detoxifies, and disperses lightly; Atractylodes lavandulata has the effects of clearing away heat and dampness, strengthening the spleen, and dispelling rheumatism.
  • Su Ye disperses to relieve the surface, promotes qi and stomach. It can not only help the production of Coix Seed, Huoxiang and Zhong, but also the honeysuckle and Atractylodes. Combination of medicines can clear heat and nourish yin, detoxify and relieve throat, and prevent Huoxiang and Cangzhu from warming and injuring yin. So Su Ye, Scrophulariaceae and Platycodon grandiflorum are all adjuvants.
  • Taizishen is a medicine that has the effect of invigorating the spleen, replenishing qi and strengthening the body, and supporting the poison to go out. It can reconcile various medicines, so that the whole prescription can help relieve the surface and dispel dampness without hurting the body.
  • the Chinese medicinal composition for detoxification, dampness and pharyngeal relief of the present invention is mainly aimed at the pathogenesis of wind pathogens and dampness.
  • the treatment method is to relieve the wind and relieve the throat, dispel dampness and promote the lung.
  • the dampness can be transformed from the triple coke and increase the way out of dampness.
  • the detoxification, dampness and pharyngeal medicine composition takes the throat as the main disease site and acts on the oral cavity, lungs and stomach, and aims at the SARS-CoV-2 asymptomatic infection pathogenesis characteristic of "dampness, toxicity, and deficiency", by increasing dampness Eliminating dampness, clearing away heat and detoxifying, replenishing qi and strengthening the body, each breaks down the characteristics of the disease, and provides an effective drug plan for the treatment of asymptomatic SARS-CoV-2 infections to meet the urgent need for treatment of asymptomatic infections. Demand, and improve the existing diagnosis and treatment plan.
  • Raw Coix Seed is the dry mature kernel of Coix lacryma-jobi L.var.ma-yuen (Roman.) Stapf, which has the functions of invigorating the spleen, removing dampness, removing numbness and diarrhea, and clearing heat and purging pus.
  • Perilla frutescens (L.) Britt's dried leaves (or with twigs) are the dried leaves (or with twigs) of Perilla frutescens (L.) Britt, which has the functions of relieving the surface and dispelling cold, promoting qi and stomach.
  • Scrophulariaceae is the dried root of Scrophularia ningpoensis Hemsl.
  • Platycodon grandiflorum is the dried root of Platycodon grandiflorum (Jacq.) A.DC., a plant of the Campanulaceae family.
  • Pseudostellaria heterophylla Pax ex Pax et Hoffm.
  • Atractylodes is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. of the Compositae family.
  • Huoxiang is the dry above-ground part of Pogostemon cablin (Blanco) Benth.
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy may preferably include the following components in parts by mass: 25-35 parts of raw coix seed, 10-15 parts of honeysuckle, 12-15 parts of sage leaves, and 10 parts of Scrophulariaceae 20 parts, 15-20 parts of Platycodon grandiflorum, 15-25 parts of Pseudostellariae, 8-12 parts of Atractylodes, 8-12 parts of Huoxiang; it can be further preferably: 30 parts of raw coix seed, 12 parts of honeysuckle, 15 parts of sesame leaves, 15 parts of Scrophulariaceae, 15 parts of Platycodon grandiflorum, 20 parts of Taizishen, 10 parts of Cangzhu, 10 parts of Huoxiang.
  • a medicine containing the above-mentioned detoxification, dampness and pharyngeal medicine composition.
  • the medicine may include a medically acceptable carrier and/or excipient.
  • the carrier or excipient may use the carriers or excipients commonly used in the art, including but not limited to starch, lactose, glucose, sodium carboxymethyl cellulose, ethyl cellulose and methyl cellulose, malt, gelatin , Polyols (such as propylene glycol, glycerol, mannitol), compressed tablets, etc.
  • the carriers or excipients commonly used in the art, including but not limited to starch, lactose, glucose, sodium carboxymethyl cellulose, ethyl cellulose and methyl cellulose, malt, gelatin , Polyols (such as propylene glycol, glycerol, mannitol), compressed tablets, etc.
  • polyols such as propylene glycol, glycerol, mannitol
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicine can be prepared by using the existing preparation method of traditional Chinese medicine preparations, with the traditional Chinese medicine composition as the main active ingredient and mixed with a carrier or excipient.
  • the required medicament such as granules, tablets, capsules, powders, pills, oral solutions, oral suspensions or oral emulsions, etc.
  • the oral solution can also be prepared in the following manner:
  • the detoxification, dampness and pharyngeal medicine composition is granular, it can be prepared by the following existing methods:
  • the detoxification, dampness and pharyngeal medicine composition is a powder
  • it can be prepared by the following existing method: take the raw material components, pulverize and uniformly mix with suitable carriers or/excipients to form a dry powder. .
  • the detoxification, dampness and pharyngeal medicine composition is a tablet
  • it can be prepared by the following existing method: take the raw material component, add the carrier or/excipient, and prepare the tablet according to the existing traditional Chinese medicine tablet preparation method Medicine; Or, the wet granules can be prepared according to the method of preparing granules, and then the wet granules can be compressed and dried to obtain the tablet medicine; or, the powder can be prepared according to the method of preparing powder, and then the excipients can be added.
  • the tablet medicine is obtained by pressing and drying.
  • the detoxification, dampness and pharyngeal medicine composition is a pill
  • it can be prepared by the following existing method: grinding the raw material components into a fine powder, adding a suitable carrier or/excipient, according to the existing preparation method of the traditional Chinese medicine pill Pill medicine can be prepared; alternatively, the wet granules can be prepared according to the method of preparing granules, then spherical or quasi-spherical, and dried to obtain the pill medicine; alternatively, the powder can be prepared according to the method of preparing powder, and then the excipients can be added.
  • the medicine is made into spherical or quasi-spherical and dried to obtain pill medicine, which will not be repeated here.
  • the application of the above-mentioned detoxification, dampness and pharyngeal medicine composition or the application of the above-mentioned medicine in the preparation of medicines for the treatment of influenza mainly for fever, cough, sore throat, sore throat caused by influenza Symptoms such as itching, dry throat, hoarse voice, fatigue, etc., are mainly for adults, pregnant women and children should be used under the guidance of a doctor.
  • the present invention also provides the application of the above-mentioned traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicine in the preparation of medicines for treating asymptomatic viral infections, especially SARS-CoV-2 asymptomatic infections.
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy or the above-mentioned medicaments are mainly aimed at patients with asymptomatic SARS-CoV-2 infection, especially those with insufficient cold and heat deficiency, and those infected with the core pathogenesis of dampness blocking the lungs and stomach.
  • the detoxification, dampness, and pharyngeal medicine composition of the present invention or the above-mentioned drugs can also be used as drugs for treating acute upper respiratory tract infections (such as the common cold, viral pharyngitis, laryngitis, herpetic angina, etc.) and chronic pharyngitis. It can also improve the symptoms of acute upper respiratory tract infection (such as common cold, viral pharyngitis, laryngitis, herpetic angina, etc.), chronic pharyngitis, such as dry throat, itchy throat, sore throat, hoarseness and other symptoms.
  • acute upper respiratory tract infections such as the common cold, viral pharyngitis, laryngitis, herpetic angina, etc.
  • chronic pharyngitis such as dry throat, itchy throat, sore throat, hoarseness and other symptoms.
  • each dose can be: raw coix seed 30g, honeysuckle 12g, sesame leaves 15g, Scrophulariaceae 15g, Platycodon grandiflorum 15g, Pseudosperma chinensis 20g, Atractylodes 10g, Huoxiang 10g), take 7-14 days, 7 days, 14 days for repeatable nucleic acid detection.
  • dampness and pharyngitis is an oral solution, an oral suspension or an oral emulsion
  • each dose is 150-300 ml, orally divided into 4 times.
  • the dosage is converted to the dosage of decoction pieces and taken, for example, 1 packet each time, 2 times a day, 50-100ml of boiling water, each packet About 6-15g.
  • the detoxification, dampness and pharyngeal medicine composition is used as an active ingredient, and its content is 10%-90% of the weight of the medicine, and the rest are auxiliary materials such as carriers or/excipients.
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngitis is a powder
  • the dosage is converted into the dosage of decoction pieces and taken.
  • the detoxification, dampness and pharyngeal medicine composition is used as an active ingredient, and its content is 10%-100% of the weight of the medicament, and the rest are auxiliary materials such as carriers or/excipients.
  • asymptomatic infections refer to: no relevant clinical manifestations, such as fever, cough, pharynx Those who have self-perceived or clinically recognizable symptoms and signs, such as pain, but the respiratory tract and other specimens have tested positive for the pathogen of the new coronavirus.
  • asymptomatic infections There are two situations for asymptomatic infections: one is that they have no self-perceived or clinically recognizable symptoms and signs after 14 days of quarantine medical observation; the other is the state of "asymptomatic infection" in the incubation period.
  • a Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 15 g of sage leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 10 g of atractylodes, and 10 g of ageratum.
  • the above-mentioned components are taken and the oral solution medicine is prepared according to the existing preparation method of traditional Chinese medicine decoction.
  • the ratio is one dose and one dose is about 200ml.
  • Oral solution drugs can be prepared by the following existing methods:
  • a Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 15 g of sage leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 10 g of atractylodes, and 10 g of ageratum.
  • Granules can be prepared by the following existing methods:
  • the filtrate was obtained according to the method of preparing the decoction in Example 1. After the filtrate was concentrated under reduced pressure to obtain a clear ointment, maltodextrin was added to the clear ointment, and then spray-dried to obtain a dry ointment powder; then, malt was added to the dry ointment powder Dextrin is used to obtain a mixed powder; then, a 90% ethanol-water solution made soft material is added to the mixed powder, and the soft material is sieved to obtain wet particles. Finally, the wet particles are dried to obtain.
  • the granules are divided into about 10g each package, which is convenient for clinical use and administration.
  • a Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: raw coix seed 25g, honeysuckle 10g, sage leaves 12g, Scrophulariaceae 12g, Platycodon grandiflorum 12g, Radix Atractylodes 15g, Atractylodes Rhizome 8g, and Agastache 8g.
  • the above components are crushed and uniformly mixed with a suitable carrier or/excipient to form a dry powder to form a powder, which can be taken with water when taking it.
  • a Chinese medicinal composition for detoxification, dampness and pharyngeal treatment is prepared from the following components: 35 g of raw coix seed, 15 g of honeysuckle, 10 g of sesame leaves, 15 g of scrophulariaceae, 16 g of platycodon, 20 g of radix ginseng, 15 g of atractylodes, 15 g of ageratum.
  • the wet granules can be prepared according to the method of Example 2, and then the wet granules are compressed and dried to obtain the tablet medicine.
  • a Chinese medicinal composition for detoxification, dampness and pharyngeal relief is prepared from the following components: 30 g of raw coix seed, 12 g of honeysuckle, 10 g of sesame leaves, 15 g of scrophulariaceae, 15 g of platycodon, 20 g of radix ginseng, 5 g of atractylodes, and 12 g of ageratum.
  • the above-mentioned components are ground into fine powder, a suitable carrier or/excipient is added, and a pill medicine is prepared according to the existing preparation method of traditional Chinese medicine pill.
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngectomy can be well used for the treatment of asymptomatic SARS-CoV-2 infections, increase the rate of negative conversion of new coronavirus pathogens in specimens such as respiratory tract, and reduce the conversion of asymptomatic infections.
  • SARS-CoV-2 asymptomatic infection belongs to the category of "epidemic disease” in traditional Chinese medicine. Its disease is caused by the exposure of the epidemic virus and the dampness of the Lingnan area. The gas phase is transmitted, because the righteousness is still strong, and the symptoms such as fever, asthma, chest suffocation, palpitations, diarrhea, fatigue, etc. are not manifested. If the righteous qi is insufficient and the qi of the epidemic disease invades the lungs and stomach, the condition may worsen during the observation and isolation period and develop new coronary pneumonia.
  • the traditional Chinese medicine composition for detoxification, dampness and pharyngeal relief of the present invention uses raw Coix Seed and Huoxiang as the monarch drugs to reduce dampness and detoxification; uses honeysuckle and atractylodes as minister drugs to clear away heat, detoxify and relieve the throat, disperse and relieve the surface, invigorate the spleen and dry dampness; Take Suye, Scrophulariaceae and Platycodon grandiflorum as adjuvants to clear away heat and nourish yin, detoxify and relieve the throat; use Taizi ginseng as a medicine to invigorate the spleen, nourish the qi and strengthen the body, and support toxins for going out; to relieve the wind and relieve the throat, dispel dampness and promote the lungs.
  • raw Coix Seed, Agastache, Atractylodes Rhizome, and Su Ye to make the wet from the triple coke and increase the way out of the wet evil.
  • the detoxification, dampness, and pharyngeal medicine composition takes the throat as the main disease site and acts on the oral cavity, lungs and stomach, and aims at the characteristics of SARS-CoV-2 asymptomatic infection pathogenesis of "dampness, toxicity, and deficiency".
  • the way out of dampness and evil is to dispel dampness and promote lungs, clear away heat and detoxify, replenish qi and strengthen the body.
  • various drugs are used to break and symptomatically provide an effective drug plan for the treatment of asymptomatic SARS-CoV-2 infections.
  • the urgent need for the treatment of asymptomatic infections has improved the existing diagnosis and treatment programs.
  • the traditional Chinese medicine composition of the present invention is effective against influenza, acute upper respiratory tract infections (common cold, viral pharyngitis, laryngitis, herpetic angina, etc.), dry throat, itching, sore throat caused by chronic pharyngitis, Symptoms such as hoarseness can also improve.
  • acute upper respiratory tract infections common cold, viral pharyngitis, laryngitis, herpetic angina, etc.
  • dry throat itching, sore throat caused by chronic pharyngitis
  • Symptoms such as hoarseness can also improve.

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Abstract

La présente invention concerne une composition de médecine traditionnelle chinoise capable d'éliminer les toxines, de supprimer la moiteur, et de décongestionner la gorge, comprenant les constituants suivants en parties en masse : de 15 à 35 parties de grains brutes de Job, de 10 à 15 parties de Flos Lonicerae, de 10 à 15 parties de Folium Perillae, de 10 à 30 parties de Radix Scrophulariae, de 10 à 20 parties de Radix Platycodi, de 15 à 30 parties de Radix Pseudostellariae, de 5 à 15 parties de Rhizoma Atractylodis, et de 5 à 15 parties d'Herba Pogostemonis. La composition est utilisée pour traiter les cas d'infection asymptomatique par le SARS-CoV-2, les symptômes tels que la toux, la gorge sèche, la gorge qui démange, le mal de gorge, et l'enrouement causés par la pharyngite chronique, et la fièvre, la toux, la gorge sèche, la gorge qui démange, le mal de gorge, l'enrouement, la fatigue, etc. causés par la grippe et les infections aiguës des voies respiratoires supérieures.
PCT/CN2020/113274 2020-04-16 2020-09-03 Composition de médecine traditionnelle chinoise capable d'éliminer les toxines, de supprimer la moiteur, et de décongestionner la gorge, et son application WO2021208335A1 (fr)

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CN202010300896.0A CN111317798A (zh) 2020-04-16 2020-04-16 解毒化湿利咽中药组合物及其应用
CN202010300896.0 2020-04-16

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CN111317798A (zh) * 2020-04-16 2020-06-23 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 解毒化湿利咽中药组合物及其应用
TWI796597B (zh) * 2020-09-21 2023-03-21 長庚大學 使用紫蘇之經水萃取的產物來對抗冠狀病毒感染的方法
CN115998824B (zh) * 2023-01-18 2024-04-30 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一种祛湿解毒的中药组合物及其制备方法和应用
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