CN108114170A - It is a kind of to be used to treat capsule medicine of rhinitis chronic and preparation method thereof - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to a kind of capsule medicine for being used to treat rhinitis chronic be provided according to the understanding mechanism of Chinese traditional treatment rhinitis chronic, each component and its mass parts ratio of the drug are as follows：The achene of Siberian cocklebur (stir-fry) 30~100g, 30~120g of river Qiang, windproof 50~120g, 30~120g of Rhizoma Gastrodiae, 30~120g of the root of Dahurain angelica, 30~100g of Radix Polygalae, 90~360g of Radix Astragali, 150~300g of Caulis Spatholobi, 30~120g of the flower bud of lily magnolia, 15~100g of asarum, 15~160g of Rhizoma Atractylodis Macrocephalae, 30~70g of cicada slough, 40~120g of peppermint etc.；Drug provided by the invention is a good Chinese prescription.

Description

It is a kind of to be used to treat capsule medicine of rhinitis chronic and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese, and in particular to and it is a kind of for treating the capsule medicine of rhinitis chronic, especially It is the field of the capsule medicine used for rhinitis chronic patient and preparation method thereof.

Background technology

It is shown according to documents and materials：Rhinitis chronic is the chronic inflammation of schneiderian membrance and submucosa.It is mainly characterized by inflammation Continuing three months or more or recurrent exerbation, protracted course of disease, the intermittent phase cannot also recover normal, and without specific pathogenic microorganisms, With different degrees of nasal obstruction, secretion increases, schneiderian membrance swelling or thicken wait obstacles.According to the pathology and function of rhinitis chronic Disorderly degree, can be divided into chronic simple rhinitis and chronic hypertrophic rhinitis, the former is increased with schneiderian membrance swelling, secretion The schneiderian membrance chronic inflammation being characterized, the latter are plump with mucous membrane, the submucosa even limitation of sclerotin or diffusivity hyperplasia With the characteristics of nasal cavity chronic inflammation.

Clinical manifestation：

A. chronic simple rhinitis

（1）Nasal obstruction feature is：It is 1. intermittent：Nasal obstruction mitigates when daytime, summer, work or movement, and night, when sitting quietly or be cold Nasal obstruction aggravates；2. alternately：Downside congestion when lying on one's side, upside nasal airflow is preferable, another when turning to another lateral position Side nasal cavity is had a stuffy nose again.

（2）Mostly translucent mucus nasal mucus, can there is purulence tears after scabies secondary infection.Nasal mucus can be flowed into through choana after and swallowed Throat, cause throat discomfort, more " phlegm " and cough etc. symptoms.Pediatric patient, can due to nasal mucus long-time stimulus vestibulum nasi and upper lip There is nasal vestibulitis and eczema.

（3）Due to nasal obstruction, nasal sound etc. when can have interruption hyposphresia, headache uncomfortable and speak.

B. chronic hypertrophic rhinitis

（1）It has a stuffy nose heavier, is mostly continuation.There are rhinolalia clausa, hyposphresia.Nasal mucus is few, be mucus or glutinous purulence, no Easily blow out.

（2）Pharyngeal opening of auditory tube is such as oppressed in loose concha nasalis inferior rear end, may occur in which tinnitus and Hearing.

（3）Due to prolonged mouth breathing and the stimulation of nasal secretion, pharyngo-laryngitis chronica easily occurs.

（4）Mostly with headache, dizzy, insomnia and the symptoms such as apathetic.

So, just how to find a kind of Chinese medicine composition that can effectively treat rhinitis chronic, be those skilled in the art urgently The problem of to be resolved.

The content of the invention

With the continuous development of China's traditional Chinese medicine, in treatment rhinitis chronic, people gradually appreciate middle treatment The advantages for the treatment of rhinitis chronic, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, control for existing doctor trained in Western medicine The present situation of rhinitis chronic is treated, the purpose of the invention is to provide a kind of for treating the capsule medicine of rhinitis chronic, with solution The problem of certainly rhinitis chronic patient gets well early.The drug is using common Chinese medicine as raw material, by selecting rational medicine Object and mass parts ratio, can effectively treat above-mentioned rhinitis chronic.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：One kind is provided for treating chronic nose Scorching capsule medicine and preparation method thereof, which is characterized in that each component and mass parts of the drug are than as follows：

It is the achene of Siberian cocklebur (stir-fry) 30~100g, 30~120g of river Qiang, windproof 50~120g, 30~120g of Rhizoma Gastrodiae, 30~120g of the root of Dahurain angelica, remote 30~100g of will, 90~360g of Radix Astragali, 150~300g of Caulis Spatholobi, 30~120g of the flower bud of lily magnolia, 15~100g of asarum, Rhizoma Atractylodis Macrocephalae 15~ 160g, 30~70g of cicada slough, 40~120g of peppermint, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

It is a kind of for treating capsule medicine of rhinitis chronic and preparation method thereof, which is characterized in that the drug it is each A component and mass parts are than as follows：

It is the achene of Siberian cocklebur (stir-fry) 36~90g, 36~105g of river Qiang, windproof 56~105g, 36~105g of Rhizoma Gastrodiae, 36~105g of the root of Dahurain angelica, remote 36~90g of will, 100~320g of Radix Astragali, 180~260g of Caulis Spatholobi, 36~105g of the flower bud of lily magnolia, 18~90g of asarum, Rhizoma Atractylodis Macrocephalae 18~ 140g, 36~60g of cicada slough, 46~105g of peppermint, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

It is a kind of for treating capsule medicine of rhinitis chronic and preparation method thereof, which is characterized in that the drug it is each A component and mass parts are than as follows：

The achene of Siberian cocklebur (stir-fry) 80g, river Qiang 95g, windproof 95g, Rhizoma Gastrodiae 95g, root of Dahurain angelica 95g, Radix Polygalae 80g, Radix Astragali 260g, Caulis Spatholobi 230g, flower bud of lily magnolia 95g, asarum 80g, Rhizoma Atractylodis Macrocephalae 120g, cicada slough 52g, peppermint 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and starch In right amount.

It is a kind of to be used to treat capsule medicine of rhinitis chronic and preparation method thereof, which is characterized in that the described method includes Following steps are prepared：

A, after above-mentioned raw materials Chinese medicine being picked impurity and dust, it is ground into according to mass parts than altogether（30~50 mesh）Graininess bag It decocts；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 60min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. liquid mixing twice is condensed into relative density is It is spray-dried to get dry extract after the medicinal extract of 1.06~1.10 (55 DEG C), so again by dry extract be pressed into particle and disinfection after It is spare；

C, the method for 1. preparing Chinese medicine capsules according to tradition by after the pellet through sieves that milled is pressed in B, adds in suitable micro mist silicon Glue, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Its capsule it is sealed after total length be 23.3mm, medicinal powder Capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

It is a kind of to be used to treat capsule medicine of rhinitis chronic and preparation method thereof, which is characterized in that the instructions of taking For：By the capsule medicine prepared to take 3 times a day, once a dose in the morning, afternoon and evening, dosage 2.5g（5）/ time, warm water It takes.7 days as a course for the treatment of, and after 2 courses for the treatment of of taking medicine, symptom gradually slows down, it is advised to renew and takes 2 courses for the treatment of, and disease, which is accused, fully recovers, 1 year Follow-up afterwards, no relapse.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine It carries.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

The achene of Siberian cocklebur (stir-fry), nature and flavor：Bitter, sweet, pungent, warm-natured, mild toxicity, have dispersing wind and cold, clearing the nasal passage, wind-damp dispelling, it is antipruritic the effect of, For treating the diseases such as nasosinusitis, anemofrigid headache, arthralgia pain due to rheumatism, rubella, eczema, mange；

River Qiang, nature and flavor：It is acrid flavour, hardship, warm-natured, there is the effect of cold dispelling wind-dispelling, damp dispelling and pain relieving, for treating cold, headache Lossless, wind-cold-dampness arthralgia, item strengthening tendons urgency, joint ache, geomantic omen edema, skin sore；

It is windproof, nature and flavor：Acrid flavour, sweet, slightly warm in nature, have expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, spasmolysis, it is antipruritic the effect of, it is outer for treating Feel chill, headache bodily pain, arthralgia pain due to rheumatism, skeletal pain, abdominal pain diarrhea, discharging fresh blood stool, lockjaw, rubella itch, sore from the beginning of Wait diseases；

Rhizoma Gastrodiae, nature and flavor：It is mild-natured, sweet in flavor, there is the effect of suppressing hyperactive liver for calming endogenous wind stops convulsion, belong to the Inflammation Zhijing of medicine for calming liver and calming endopathic wind subordinate classification Medicine, for treating the diseases such as dizziness of having a headache, extremity numbness, child convulsion, epilepsy clonus, lockjaw；

The root of Dahurain angelica, nature and flavor：It is acrid flavour, warm-natured, there is dispelling wind and eliminating dampness, logical the effect of stealing analgesic, detumescence and apocenosis, for treating head of catching a cold Bitterly, pain in the supra-orbital bone, toothache, nasal obstruction, nasosinusitis, wet victory chronic diarrhea, women leukorrhea, ulcer sores, venomous snake bite；

Radix Polygalae, nature and flavor：It is bitterly, warm-natured, there is the effect of tranquilize the mind and promote the intelligence, eliminating the phlegm, strongly fragrant solution, for treating palpitation with fear, forgetful, dream Something lost, insomnia, cough ant phlegm, ulcer sore swells；

Radix Astragali, nature and flavor：Sweet, tepor has the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating the deficiency of vital energy Weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, burst for a long time and does not holds back, The diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；

Caulis Spatholobi, nature and flavor：It is bitter, micro-sweet, warm-natured, there is the effect of activating blood and relaxing tendons, nourishing blood for regulating menstruation, for treat it is numb in every limb, Quadriplegia, arthralgia pain due to rheumatism, women have through diseases such as uncomfortable, dysmenorrhoea, amenorrhoeas；

The flower bud of lily magnolia, nature and flavor：It is pungent, warm-natured, there is the effect of dispersing wind and cold, clearing the nasal passage, for treating the headache of nasosinusitis, anemofrigid cold, nose The diseases such as plug, runny nose；

Asarum, nature and flavor：It is pungent, warm, there is wind-dispelling, cold dispelling, Hang Shui, the effect of having one's ideas straightened out, for treat air-cooled headache, nasosinusitis, dentalgia, Phlegm and retained fluid cough is inverse, arthralgia pain due to rheumatism；

Rhizoma Atractylodis Macrocephalae, nature and flavor：It is bitter, sweet, warm-natured, there is the effect of strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis, for treating temper Weakness, spiritlessness and weakness, deficiency of food lack thin abdominal distension, big loose stool, fluid retention stagnating in the interior, difficult urination, oedema, phlegmatic vertigo, warm numbness are ached, gas The diseases such as empty spontaneous perspiration, fetal irritability；

Cicada slough, nature and flavor：It is sweet in flavor, salty, cool in nature, there is the work(that dispelling wind and heat from the body, relieving sore-throat open sound, promoting eruption, removing nebula, Inflammation Zhijing Effect, for treat anemopyretic cold, warm disease from the beginning of, it is pharyngalgia hoarse voice, measles without adequate eruption, rubella itch, cataract, anxious chronic infantile convulsion, broken Cold card, nocturnal fretfulness in infants are uneasy；

Peppermint, nature and flavor：It is pungent, cool, have dispelling wind, radiate, ward off it is dirty, removing toxic substances the effect of, for treat affection of exogenous wind-heat, headache, hot eyes, The diseases such as abscess of throat, food stagnation inflatable, aphtha, toothache, sore scabies, urticaria.

Drug of the present invention is the principle based on Chinese traditional treatment rhinitis chronic, from the pathomechanism and pharmacology according to rhinitis chronic Effect is thought：With regard to rhinitis chronic, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, is had very well to above-mentioned disease Therapeutic effect.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned rhinitis chronic is prepared using the formula Medicine effect is good, quick, is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific of the present invention Embodiment is described in further detail：

Embodiment 1：

A kind of capsule medicine for being used to treat rhinitis chronic, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

The achene of Siberian cocklebur (stir-fry) 80g, river Qiang 95g, windproof 95g, Rhizoma Gastrodiae 95g, root of Dahurain angelica 95g, Radix Polygalae 80g, Radix Astragali 260g, Caulis Spatholobi 230g, flower bud of lily magnolia 95g, asarum 80g, Rhizoma Atractylodis Macrocephalae 120g, cicada slough 52g, peppermint 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and starch In right amount.

Embodiment 2：

A kind of capsule medicine for being used to treat rhinitis chronic, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

The achene of Siberian cocklebur (stir-fry) 90g, river Qiang 105g, windproof 105g, Rhizoma Gastrodiae 105g, root of Dahurain angelica 105g, Radix Polygalae 90g, Radix Astragali 320g, chicken blood Rattan 260g, flower bud of lily magnolia 105g, asarum 90g, Rhizoma Atractylodis Macrocephalae 140g, cicada slough 60g, peppermint 105g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and Appropriate starch.

Embodiment 3：

A kind of capsule medicine for being used to treat rhinitis chronic, which is characterized in that each component and the mass parts ratio of the drug It is as follows：

The achene of Siberian cocklebur (stir-fry) 100g, river Qiang 120g, windproof 120g, Rhizoma Gastrodiae 120g, root of Dahurain angelica 120g, Radix Polygalae 100g, Radix Astragali 360g, chicken Blood rattan 300g, flower bud of lily magnolia 120g, asarum 100g, Rhizoma Atractylodis Macrocephalae 160g, cicada slough 70g, peppermint 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose It is appropriate with starch.

Model case：

Through clinical conditions rhinitis chronic patient totally 1530, the age is 917 of 22 years old or more, and only 613 are 22 years old Below.That fully recovers in 1530 patients has 1076, effective 377, invalid 77.Total effective rate is up to 95%.

Claims (3)

1. a kind of capsule medicine for being used to treat rhinitis chronic, which is characterized in that each component and mass parts of the drug Than as follows：

It is the achene of Siberian cocklebur (stir-fry) 30~100g, 30~120g of river Qiang, windproof 50~120g, 30~120g of Rhizoma Gastrodiae, 30~120g of the root of Dahurain angelica, remote 30~100g of will, 90~360g of Radix Astragali, 150~300g of Caulis Spatholobi, 30~120g of the flower bud of lily magnolia, 15~100g of asarum, Rhizoma Atractylodis Macrocephalae 15~ 160g, 30~70g of cicada slough, 40~120g of peppermint, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

It is 2. according to claim 1 for treating the capsule medicine of rhinitis chronic, which is characterized in that the drug it is each A component and mass parts are than as follows：

It is the achene of Siberian cocklebur (stir-fry) 36~90g, 36~105g of river Qiang, windproof 56~105g, 36~105g of Rhizoma Gastrodiae, 36~105g of the root of Dahurain angelica, remote 36~90g of will, 100~320g of Radix Astragali, 180~260g of Caulis Spatholobi, 36~105g of the flower bud of lily magnolia, 18~90g of asarum, Rhizoma Atractylodis Macrocephalae 18~ 140g, 36~60g of cicada slough, 46~105g of peppermint, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

3. the capsule medicine for being used to treat rhinitis chronic according to claim 1 to 2, which is characterized in that the drug Each component and mass parts than as follows：

The achene of Siberian cocklebur (stir-fry) 80g, river Qiang 95g, windproof 95g, Rhizoma Gastrodiae 95g, root of Dahurain angelica 95g, Radix Polygalae 80g, Radix Astragali 260g, Caulis Spatholobi 230g, flower bud of lily magnolia 95g, asarum 80g, Rhizoma Atractylodis Macrocephalae 120g, cicada slough 52g, peppermint 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and starch In right amount.