CN108186924A - A kind of new medicine composition for treating rhinitis chronic and preparation method - Google Patents

Abstract

The invention belongs to field of traditional Chinese, it is therefore an objective to provide a kind of new medicine composition for treating rhinitis chronic according to the understanding mechanism of Chinese traditional treatment rhinitis chronic, each component and its mass parts ratio of the new medicine composition are as follows：80~150g of the achene of Siberian cocklebur, 50~120g of mulberry leaf, 50~160g of Flos Magnoliae Liliflorae, 100~160g of wild chrysanthemum, 80~150g of almond, 50~160g of polished rice, 60~100g of Centipeda minima, 90~360g of raw Radix Astragali, 100~260g of cacumen biotae, 50~120g of Rhizoma Chuanxiong, 30~120g of the root of Dahurain angelica, 80~160g of Rhizoma Atractylodis Macrocephalae, 30~150g of CORTEX PHELLODENDRI CHINENSE, windproof 50~120g, 30~150g of Radix Glycyrrhizae, 150~560g of eclipta, 30~80g of caraway, 50~100g of campanulaceae, 150~350g of Radix Paeoniae Alba, 60~120g of white disease multitude etc.；Drug provided by the invention is a good Chinese prescription.

Description

A kind of new medicine composition for treating rhinitis chronic and preparation method

Technical field

The invention belongs to field of traditional Chinese, and in particular to a kind of new medicine composition for treating rhinitis chronic, especially It is the field of the new medicine composition and preparation method used for rhinitis chronic patient.

Background technology

Doctor thinks：Rhinitis chronic is the chronic inflammation of schneiderian membrance and submucosa.It is mainly characterized by inflammation and continues three A month or more or recurrent exerbation, protracted course of disease, the intermittent phase cannot also restore normal, and without specific pathogenic microorganisms, with not With the nasal obstruction of degree, secretion increases, schneiderian membrance swelling or thicken wait obstacles.According to the pathology of rhinitis chronic and dysfunction Degree can be divided into chronic simple rhinitis and chronic hypertrophic rhinitis, the former is characterized by schneiderian membrance swelling, secretion increase Schneiderian membrance chronic inflammation, the latter is with the characteristics of mucous membrane, the submucosa even limitation of sclerotin or diffusivity hyperplasia plumpness Nasal cavity chronic inflammation.

Clinical manifestation：

A. chronic simple rhinitis

（1）Nasal obstruction feature is：It is 1. intermittent：Nasal obstruction mitigates when daytime, summer, labour or movement, and night, when sitting quietly or be cold Nasal obstruction aggravates；2. alternately：Downside congestion when lying on one's side, upside nasal airflow is preferable, another when turning to another lateral position Side nasal cavity is had a stuffy nose again.

（2）Mostly translucent mucus nasal mucus, can there is purulence tears after secondary infection.Nasal mucus can be flowed into through choana after and be swallowed Throat, cause throat discomfort, more " phlegm " and cough etc. symptoms.Pediatric patient, can due to nasal mucus long-time stimulus vestibulum nasi and upper lip There is nasal vestibulitis and eczema.

（3）Due to nasal obstruction, nasal sound etc. when can have interruption hyposphresia, headache uncomfortable and speak.

B. chronic hypertrophic rhinitis

（1）It has a stuffy nose heavier, mostly duration.There are rhinolalia clausa, hyposphresia.Nasal mucus is few, be mucus or glutinous purulence, no Easily blow out.

（2）Pharyngeal opening of auditory tube is such as oppressed in loose concha nasalis inferior rear end, may occur in which tinnitus and Hearing.

（3）Due to prolonged mouth breathing and the stimulation of nasal secretion, pharyngo-laryngitis chronica easily occurs.

（4）Mostly with headache, dizzy, insomnia and the symptoms such as apathetic.

So, just how to find a kind of Chinese medicine composition that can effectively treat rhinitis chronic, be those skilled in the art urgently The problem of to be resolved.

Invention content

With the continuous development of China's traditional Chinese medicine, in treatment rhinitis chronic, people gradually appreciate middle treatment The advantages for the treatment of rhinitis chronic, and good effect, the advantages such as quick, toxic side effect is small over the course for the treatment of, control for existing doctor trained in Western medicine The present situation of rhinitis chronic is treated, the purpose of the invention is to provide a kind of new medicine composition for treating rhinitis chronic, with solution The problem of certainly rhinitis chronic patient gets well early.The drug is using common Chinese medicine as raw material, by selecting rational medicine Object and mass parts ratio, can effectively treat above-mentioned rhinitis chronic.

To achieve the purpose that foregoing invention, the technical solution adopted in the present invention is：A kind of rhinitis chronic for the treatment of is provided New medicine composition and preparation method, which is characterized in that each component and mass parts of the new medicine composition are such as Shown in lower：

80~150g of the achene of Siberian cocklebur, 50~120g of mulberry leaf, 50~160g of Flos Magnoliae Liliflorae, 100~160g of wild chrysanthemum, 80~150g of almond, It is 50~160g of polished rice, 60~100g of Centipeda minima, raw 90~360g of Radix Astragali, 100~260g of cacumen biotae, 50~120g of Rhizoma Chuanxiong, white 30~120g of the root of Dahurian angelica, 80~160g of Rhizoma Atractylodis Macrocephalae, 30~150g of CORTEX PHELLODENDRI CHINENSE, windproof 50~120g, 30~150g of Radix Glycyrrhizae, eclipta 150~ 560g, 30~80g of caraway, 50~100g of campanulaceae, 150~350g of Radix Paeoniae Alba, 60~120g of white disease multitude, auxiliary material：Superfine silica gel powder, crystallite Cellulose and appropriate starch.

A kind of new medicine composition for treating rhinitis chronic and preparation method, which is characterized in that the new medicine group The each component and mass parts of conjunction object are than as follows：

90~130g of the achene of Siberian cocklebur, 56~105g of mulberry leaf, 56~140g of Flos Magnoliae Liliflorae, 115~140g of wild chrysanthemum, 90~130g of almond, It is 56~140g of polished rice, 70~90g of Centipeda minima, raw 100~320g of Radix Astragali, 115~220g of cacumen biotae, 56~105g of Rhizoma Chuanxiong, white 36~105g of the root of Dahurian angelica, 90~140g of Rhizoma Atractylodis Macrocephalae, 36~130g of CORTEX PHELLODENDRI CHINENSE, windproof 56~105g, 36~130g of Radix Glycyrrhizae, eclipta 180~ 480g, 36~70g of caraway, 56~90g of campanulaceae, 180~310g of Radix Paeoniae Alba, 70~105g of white disease multitude, auxiliary material：Superfine silica gel powder, crystallite Cellulose and appropriate starch.

A kind of new medicine composition for treating rhinitis chronic and preparation method, which is characterized in that the new medicine group The each component and mass parts of conjunction object are than as follows：

Achene of Siberian cocklebur 115g, mulberry leaf 95g, Flos Magnoliae Liliflorae 120g, wild chrysanthemum 120g, almond 118g, polished rice 120g, Centipeda minima 80g, life Radix Astragali 260g, cacumen biotae 200g, Rhizoma Chuanxiong 95g, root of Dahurain angelica 95g, Rhizoma Atractylodis Macrocephalae 120g, CORTEX PHELLODENDRI CHINENSE 118g, windproof 95g, Radix Glycyrrhizae 118g, ink drought Lotus 420g, caraway 60g, campanulaceae 80g, Radix Paeoniae Alba 280g, white disease multitude 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

A kind of new medicine composition for treating rhinitis chronic and preparation method, which is characterized in that the method includes such as Lower step is prepared：

A, it after above-mentioned raw materials Chinese medicine being picked impurity and dust, is ground into according to mass parts than altogether（30~50 mesh）Graininess packet It decocts；

B, 1. the raw material Chinese medicine wrapped is put into cold boiling water and impregnates 50min, then soaked drug is put into marmite again, The cold boiling water for adding in 7~9 times of raw material Chinese medicine weight carries out first time high heat decoction, when decocting to 18min, turns slow boiling tanning 120min, leaching liquid；2. the cold boiling water for adding in 6~8 times of raw material Chinese medicine weight in the dregs of a decoction again is fried by intense fire for the second time It boils, when decocting to 15min, turns slow boiling tanning 110min, leaching liquid；3. liquid mixing twice is condensed into relative density is It is spray-dried to get dry extract after the medicinal extract of 1.06~1.10 (55 DEG C), so again by dry extract be pressed into particle and disinfection after It is spare；

C, the method for 1. preparing Chinese medicine capsules according to tradition after the pellet through sieves that milled is pressed in B, adds in suitable micro mist silicon Glue, microcrystalline cellulose and starch are uniformly mixed, and are then prepared into capsule（Its capsule it is sealed after total length be 23.3mm, medicinal powder Capacity 0.4~0.5g/）, 2. then polish, sterilize, sealed packaging.

A kind of new medicine composition for treating rhinitis chronic and preparation method, which is characterized in that the instructions of taking is： By the capsule medicine prepared three times a day to take, once a dose in the morning, afternoon and evening, dosage 2.4g（6）/ time, warm water is sent Clothes.7 days as a course for the treatment of, and after 3 courses for the treatment of of taking medicine, symptom significantly slows down, it is advised to renew and takes 1 course for the treatment of, the disease is cured.Follow-up Half a year, no relapse.

Each raw material Chinese medicine in prescription of the present invention has detailed note in Chinese Pharmacopoeia, Chinese dictionary and China's book on Chinese herbal medicine It carries.It is raw material that the present invention, which selects one of the most common Chinese medicine, gives full play to the pharmacological effect of each component：

The achene of Siberian cocklebur, nature and flavor：Bitter, sweet, pungent, warm-natured, mild toxicity, have dispersing wind and cold, clearing the nasal passage, wind-damp dispelling, it is antipruritic the effect of, be used for Treat the diseases such as nasosinusitis, anemofrigid headache, arthralgia pain due to rheumatism, rubella, eczema, mange；

Mulberry leaf, nature and flavor：It is bitter, sweet, cold in nature, there is the effect of dispelling wind and heat from the body, clearing away the lungheat and moisturizing, flat liver improving eyesight, cooling blood and hemostasis, be used for Treat anemopyretic cold, warm disease from the beginning of, cough with lung heat, the diseases such as liver-yang hyperactivity dizziness, hot eyes be dim-sighted, hemoptysis of blood-heat bleeding, haematemesis；

Flos Magnoliae Liliflorae, nature and flavor：It is pungent, warm, there is the effect of wind-dispelling, sensible, for treating headache, nasosinusitis, obstructed, dentalgia of having a stuffy nose etc. Disease；

Wild chrysanthemum, nature and flavor：It is bitter, pungent, mild-natured, there is the effect of clearing heat and detoxicating, dispelling wind soothing the liver, for treating furunculosis, ulcer, pellet Poison, eczema, dermatitis, anemopyretic cold, abscess of throat, high blood pressure；

Almond, nature and flavor：Bitter, slightly warm in nature, it is slightly poisonous, have expelling phlegm and arresting coughing, relieving asthma, ease constipation the effect of, for treat exogenous cough, Asthma is full, larynx numbness, dry constipation of intestines；

Polished rice, nature and flavor：It is sweet, flat, there is the effect of tonifying middle-Jiao and Qi, strengthening the spleen and stomach, relieving thirst and restlessness, antidiarrheal dysentery, for treating cholera, abdomen It rushes down, the diseases such as dysentery；

Centipeda minima, nature and flavor：It is acrid flavour, warm-natured, there is the effect of expelling cold, eliminating, clearing the nasal passage, cough-relieving, for treat anemofrigid headache, Coughing with a lot of sputum, obstructed, nasosinusitis runny nose of having a stuffy nose；

Raw Radix Astragali, nature and flavor：Sweet, tepor has the effect of invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation, for treating gas Empty weak, anorexia and loose stool, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy oedema, ulcer is difficult to burst, is burst not at the sinking of qi of middle-jiao long It holds back, the diseases such as flaccidity of limbs due to deficiency of blood is yellow, Heat Diabetes, chronic rephrilis protinuria, diabetes；

Cacumen biotae, nature and flavor：It is bitter, cold, there is cooling blood and hemostasis, cough-relieving apophlegmatic, wind-damp dispelling, dissipate the effect of pyogenic infections, coughed up for treating Blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematuria, bloody flux, discharging fresh blood stool, uterine bleeding are more than, coughing with a lot of sputum, arthralgia pain due to rheumatism, erysipelas, mumps, scald, also For hematemesis and epistaxis, spit blood, have blood in stool, metrostaxis, blood-head alopecia, poliosis；

Rhizoma Chuanxiong, nature and flavor：It is pungent, warm, there is the effect of wet promote breath and open depression, method wind-dryness, promoting blood circulation and stopping pain, for treating air-cooled headache rotation Dizzy, hypochondriac pain abdomen pain, arthritis muscle contraction, Amenorrhea, difficult labour, postpartum stasis block pain, ulcer sores, irregular menstruation, lump in the abdomen abdominal pain, chest side of body thorn Bitterly, tumbling and swelling, arthralgia pain due to rheumatism；

The root of Dahurain angelica, nature and flavor：It is acrid flavour, warm-natured, there is dispelling wind and eliminating dampness, logical the effect of stealing analgesic, detumescence and apocenosis, for treating head of catching a cold Bitterly, pain in the supra-orbital bone, toothache, nasal obstruction, nasosinusitis, wet victory chronic diarrhea, women leukorrhea, ulcer sores, venomous snake bite；

Rhizoma Atractylodis Macrocephalae, nature and flavor：It is bitter, sweet, warm-natured, there is the effect of strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis, for treating temper Weakness, spiritlessness and weakness, deficiency of food lack thin abdominal distension, big loose stool, fluid retention stagnating in the interior, difficult urination, oedema, phlegmatic vertigo, warm numbness are ached, gas The diseases such as empty spontaneous perspiration, fetal irritability；

CORTEX PHELLODENDRI CHINENSE, nature and flavor：It is bitter, cold in nature, there is the effect of heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment, for treating damp and hot rush down Dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence knit, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore, Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire, for fire excess from yin deficiency, night sweat hectic fever due to yin；

It is windproof, nature and flavor：Acrid flavour, sweet, slightly warm in nature, have expel pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, spasmolysis, it is antipruritic the effect of, it is outer for treating Feel chill, headache bodily pain, arthralgia pain due to rheumatism, skeletal pain, abdominal pain diarrhea, discharging fresh blood stool, lockjaw, rubella itch, sore from the beginning of Wait diseases；

Radix Glycyrrhizae, nature and flavor：It is sweet, flat, have invigorating middle warmer and replenishing QI, relieving spasm to stop pain, moisten the lung and relieve the cough, purging intense heat and detonicating, coordinating the drug actions of a prescription the effect of, use It swells in treatment burnout deficiency of food, the thin face Huang of flesh, palpitation, abdominal pain loose stool, four limbs contraction, hysteria, cough and asthma, throat Bitterly, ulcerative carbuncle swelling and pain, infant fetal toxin and drug, food poisoning；

Eclipta, nature and flavor：It is acid sweet in flavor, cool in nature, there is the effect of cool blood, hemostasis, kidney tonifying, benefit cloudy, for treat haematemesis, hemoptysis, Bleeding from five sense organs or subcutaneous tissue, hematuria, have blood in stool, bloody flux, knife wound bleeding, poliosis, diphtheria, stranguria with turbid discharge, under band, private parts is wet itches；

Caraway, nature and flavor：It is pungent, warm, there is sweating promoting eruption, the lower gas that helps digestion, the effect of being amusing and is middle, for treating measles initial stage, thoroughly Go out not smooth and food stagnate, the illnesss such as appetite is not opened, rectal prolapse；

Campanulaceae, nature and flavor：It is toil, flat, there is the effect of open the inhibited lung-energy, eliminating the phlegm apocenosis, for treat exogenous cough, abscess of throat, Lung carbuncle pyemesis, fullness in the chest and hypochondriac pain, dysentery abdominal pain；

Radix Paeoniae Alba, nature and flavor：Hardship, is slightly cold at acid, has blood-nourishing and battalion, relieving spasm to stop pain, holds back the effect of high and level tone liver, for treating menstruation not The diseases such as tune, dysmenorrhea, uterine bleeding, spontaneous perspiration, night sweat, side of body rib epigastric pain, four limbs contraction pain, headache, dizziness；

White disease multitude, nature and flavor：It is bitter, pungent, flat, there is the effect of flat liver solution strongly fragrant, dispelling pathogenic wind for improving eyesight, for treating dizziness due to hyperactivity of liver-YANG headache, liver The diseases such as strongly fragrant hypochondriac pain, headache due to pathogenic wind-heat, red eye, swell pain, pruitus.

Drug of the present invention is the principle based on Chinese traditional treatment rhinitis chronic, from the pathomechanism and pharmacology according to rhinitis chronic Effect is thought：With regard to rhinitis chronic, each raw material herbal medicine efficacy in drug provided by the present invention is played altogether, is had very well to above-mentioned disease Therapeutic effect.

Specific embodiment

A kind of Chinese medicine preparation that the present invention is proposed aiming at the treatment of above-mentioned rhinitis chronic is prepared using the formula Medicine effect is good, quick, is a good Chinese prescription, is particularly suitable for Clinical practice.With reference to the specific of the present invention Embodiment is described in further detail：

Embodiment 1：

A kind of new medicine composition for treating rhinitis chronic, which is characterized in that each component of the new medicine composition And mass parts are than as follows：

Achene of Siberian cocklebur 115g, mulberry leaf 95g, Flos Magnoliae Liliflorae 120g, wild chrysanthemum 120g, almond 118g, polished rice 120g, Centipeda minima 80g, life Radix Astragali 260g, cacumen biotae 200g, Rhizoma Chuanxiong 95g, root of Dahurain angelica 95g, Rhizoma Atractylodis Macrocephalae 120g, CORTEX PHELLODENDRI CHINENSE 118g, windproof 95g, Radix Glycyrrhizae 118g, ink drought Lotus 420g, caraway 60g, campanulaceae 80g, Radix Paeoniae Alba 280g, white disease multitude 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.

Embodiment 2：

A kind of new medicine composition for treating rhinitis chronic, which is characterized in that each component of the new medicine composition And mass parts are than as follows：

Achene of Siberian cocklebur 130g, mulberry leaf 105g, Flos Magnoliae Liliflorae 140g, wild chrysanthemum 140g, almond 130g, polished rice 140g, Centipeda minima 90g, Raw Radix Astragali 320g, cacumen biotae 220g, Rhizoma Chuanxiong 105g, root of Dahurain angelica 105g, Rhizoma Atractylodis Macrocephalae 140g, CORTEX PHELLODENDRI CHINENSE 130g, windproof 105g, Radix Glycyrrhizae 130g, eclipta 480g, caraway 70g, campanulaceae 90g, Radix Paeoniae Alba 310g, white disease multitude 105g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose It is appropriate with starch.

Embodiment 3：

A kind of new medicine composition for treating rhinitis chronic, which is characterized in that each component of the new medicine composition And mass parts are than as follows：

Achene of Siberian cocklebur 150g, mulberry leaf 120g, Flos Magnoliae Liliflorae 160g, wild chrysanthemum 160g, almond 150g, polished rice 160g, Centipeda minima 100g, Raw Radix Astragali 360g, cacumen biotae 260g, Rhizoma Chuanxiong 120g, root of Dahurain angelica 120g, Rhizoma Atractylodis Macrocephalae 160g, CORTEX PHELLODENDRI CHINENSE 150g, windproof 120g, Radix Glycyrrhizae 150g, eclipta 560g, caraway 80g, campanulaceae 100g, Radix Paeoniae Alba 350g, white disease multitude 120g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose It is appropriate with starch.

Model case：

Through clinical conditions rhinitis chronic patient totally 1632, the age is 968 of 19 years old or more, and only 664 are 19 years old Below.That fully recovers in 1632 patients has 1142, effective 425, invalid 65.Total effective rate is up to 96%.

Claims (3)

1. A kind of 1. new medicine composition for treating rhinitis chronic, which is characterized in that each group of the new medicine composition Divide and mass parts are than as follows：

   80~150g of the achene of Siberian cocklebur, 50~120g of mulberry leaf, 50~160g of Flos Magnoliae Liliflorae, 100~160g of wild chrysanthemum, 80~150g of almond, It is 50~160g of polished rice, 60~100g of Centipeda minima, raw 90~360g of Radix Astragali, 100~260g of cacumen biotae, 50~120g of Rhizoma Chuanxiong, white 30~120g of the root of Dahurian angelica, 80~160g of Rhizoma Atractylodis Macrocephalae, 30~150g of CORTEX PHELLODENDRI CHINENSE, windproof 50~120g, 30~150g of Radix Glycyrrhizae, eclipta 150~ 560g, 30~80g of caraway, 50~100g of campanulaceae, 150~350g of Radix Paeoniae Alba, 60~120g of white disease multitude, auxiliary material：Superfine silica gel powder, crystallite Cellulose and appropriate starch.
2. 2. the new medicine composition for the treatment of rhinitis chronic according to claim 1, which is characterized in that the new medicine The each component and mass parts of composition are than as follows：

   90~130g of the achene of Siberian cocklebur, 56~105g of mulberry leaf, 56~140g of Flos Magnoliae Liliflorae, 115~140g of wild chrysanthemum, 90~130g of almond, It is 56~140g of polished rice, 70~90g of Centipeda minima, raw 100~320g of Radix Astragali, 115~220g of cacumen biotae, 56~105g of Rhizoma Chuanxiong, white 36~105g of the root of Dahurian angelica, 90~140g of Rhizoma Atractylodis Macrocephalae, 36~130g of CORTEX PHELLODENDRI CHINENSE, windproof 56~105g, 36~130g of Radix Glycyrrhizae, eclipta 180~ 480g, 36~70g of caraway, 56~90g of campanulaceae, 180~310g of Radix Paeoniae Alba, 70~105g of white disease multitude, auxiliary material：Superfine silica gel powder, crystallite Cellulose and appropriate starch.
3. 3. the new medicine composition of the treatment rhinitis chronic according to claim 1 to 2, which is characterized in that described novel The each component and mass parts of Chinese medicine composition are than as follows：

   Achene of Siberian cocklebur 115g, mulberry leaf 95g, Flos Magnoliae Liliflorae 120g, wild chrysanthemum 120g, almond 118g, polished rice 120g, Centipeda minima 80g, life Radix Astragali 260g, cacumen biotae 200g, Rhizoma Chuanxiong 95g, root of Dahurain angelica 95g, Rhizoma Atractylodis Macrocephalae 120g, CORTEX PHELLODENDRI CHINENSE 118g, windproof 95g, Radix Glycyrrhizae 118g, ink drought Lotus 420g, caraway 60g, campanulaceae 80g, Radix Paeoniae Alba 280g, white disease multitude 95g, auxiliary material：Superfine silica gel powder, microcrystalline cellulose and appropriate starch.