CN105396105A - A method of preparing a traditional Chinese medicine composition for preventing and treating recurrent common cold in children - Google Patents
A method of preparing a traditional Chinese medicine composition for preventing and treating recurrent common cold in children Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a method of preparing a traditional Chinese medicine composition for preventing and treating recurrent common cold in children and belongs to the technical field of traditional Chinese medicines. The method includes a step of extracting dwarf lilyturf tuber and separating by vacuum distillation to obtain a dwarf lilyturf tuber extract, a step of cleaning hogfennel root, blackberry lily rhizome, tatarian aster root and white mustard seed, drying, smashing, combining with the dreg of the dwarf lilyturf tuber, and extracting to obtain an extract A, a step of subjecting leave of common perilla, common coltsfoot flower, platycodon root, chrysanthemum flower, dried tangerine peel, dry ginger and liquorice root to reflux extraction to obtain an extract B, and a step of combining the dwarf lilyturf tuber extract, the extract A and the extract B, and drying under reduced pressure to obtain the composition. The composition has effects of clearing heat and toxins, freeing lung, relieving asthma, drying dampness, dissolving phlegm, dissipating dampness and improving appetite, and has significant curative effects for symptoms caused by the common cold in children, such as fever, cough, a running nose, a stuffy nose, vomit and diarrhea. The composition is reasonable in raw material compatibility, low in cost, free of side and toxic effects and suitable for children and deserves wide clinical application.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of method preparing the Chinese medicine composition of control infantile recurrent common cold.
Background technology
Flu is one of common outer perceptual disease in children's period, clinical with fever with chills, headache nasal obstruction, watery nasal discharge cough for feature.Flu is also known as cold.Flu can be divided into two kinds, and common cold is for emitting by caused by ailment said due to cold or exposure, and general pathogenic factor is gently shallow, based on the symptom of lung system, does not cause popular; Influenza is for experiencing caused by seasonal pathogen virus, and pathogenic factor is heavier, has epidemiological features.Primary disease sickness rate accounts for pediatric disease first place, except the less morbidity of children's within 4-5 month, can betide the children's at any age.Primary disease all can be fallen ill throughout the year, common with Winter-Spring, and when seasonal variations, weather cataclysm, sickness rate is high.Children's catches a cold, and because of its physiological and pathological feature, is easy to occur folder expectorant, presss from both sides stagnant, that folder is frightened double folder card.
The cause of disease of infantile common cold has diseases caused by exogenous pathogenic factor factor and weakened body resistance factor.Etiological is being invaded by exogenous pathogen, based on ailment said due to cold or exposure, normal hold concurrently assorted cold, heat, summer-heat, wet, dry etc., also to have when experiencing caused by row epidemic disease poison.Whether exopathogen invades human body, fall ill, also relevant with the power of healthy energy, meets with exopathogen invasion and attack when children's defends outer miopragia, be then easy to feel evil morbidity.The base therapy principle of flu is dispelling wind to relieve the exterior syndrome.Because children's is the body of immature yin and yang, diaphoresis should not too, in order to avoid consume body fluid.Infantile common cold is easily cold from transconversion into heat, or heat is constipation due to cold pathogen, forms the card of intermingling cold and heat, and alone pungent cool sweating is not saturating, and alone pungent temperature probably helps transconversion into heat fire, often gets the pungent Wen Bingyong of Xin Liang.The re-heat after the easy sweating of alone diaphoretic therapy if catch a cold, heat-clearing and toxic substances removing, clearing away summer-heat and eliminating dampness should be share according to card feelings, reduce phlegm help digestion, the relieving convulsion method for the treatment of such as to relieve dizziness, high fever, infantile convulsions, epilepsy, etc.The person of having a delicate constitution should not too deliver, or adopts method of strengthening body resistance and relieveing exterior syndrome.Children with repeated respiratory tract infections should be nursed one's health in time after flu, improves body constitution, enhancing immunity.
Treatment at present for infantile common cold is mainly divided into western medical treatment and Chinese traditional treatment.Western medical treatment is mainly based on antibiotic, NSAID (non-steroidal anti-inflammatory drug), antihistaminic etc., and these drug side effectes are many, and what have even can cause serious untoward reaction, totally unfavorable to the Health restoration of child; The traditional Chinese medical science is in treatment infantile common cold, and mainly based on Chinese patent medicine, not only dosage is large, drug absorption slow, and patient compliance is poor, does not feel any better for a long time, and often delay treatment, aggravates disease.
Chinese patent application 201310634057 discloses a kind of oral liquid for the treatment of infantile common cold, this oral liquid is prepared from by the raw material of following weight portion: Herba Rostellulariae, Herba Arthraxonis Hispidi, the Plantula cucurbitae moschatae, Concretio Silicea Bambusae, Folium et Caulis Indigoferae Tinctoriae, Stigma Maydis, Radix Platycodonis, Periostracum Cicadae, Radix Asteris, carambola, Bulbus Lilii, Cortex Phellodendri, Radix Dauci Sativae, Radix Puerariae, Radix Cynanchi Atrati and Caulis Sacchari sinensis, this invention oral liquid has effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, lung moistening sending down the abnormal ascending QI, but this oral liquid component is complicated, treatment infantile common cold is cured the symptoms, not the disease, easily recurrence more.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition preventing and treating infantile recurrent common cold, and this Chinese medicine composition has relieving cough and resolving phlegm, depressed lung-energy dispersing, effect of regulating qi-flowing for strengthening spleen and removing dampness appetizing, also have good effect, side effect is low, the advantage such as treating both the principal and secondary aspects of a disease and taking convenience.In addition, the present invention also provides corresponding preparation method to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this Chinese medicine composition.
The technical solution used in the present invention is:
Prevent and treat a Chinese medicine composition for infantile recurrent common cold, be prepared from by the medical material of following weight portion: Radix Ophiopogonis 10-20 part, Radix Peucedani 10-22 part, Rhizoma Belamcandae 12-18 part, Folium Perillae Frutescentis 12-20 part, Flos Farfarae 12-24 part, Radix Platycodonis 8-16 part, Flos Chrysanthemi 8-14 part, Radix Asteris 8-16 part, Semen Sinapis Albae 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Rhizoma Zingiberis 6-10 part and Radix Glycyrrhizae 2-10 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 10 parts, Radix Peucedani 10 parts, Rhizoma Belamcandae 12 parts, Folium Perillae Frutescentis 12 parts, Flos Farfarae 12 parts, Radix Platycodonis 8 parts, Flos Chrysanthemi 8 parts, Radix Asteris 8 parts, Semen Sinapis Albae 8 parts, Pericarpium Citri Reticulatae 8 parts, Rhizoma Zingiberis 6 parts and 2 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 20 parts, Radix Peucedani 22 parts, Rhizoma Belamcandae 18 parts, Folium Perillae Frutescentis 20 parts, Flos Farfarae 24 parts, Radix Platycodonis 16 parts, Flos Chrysanthemi 14 parts, Radix Asteris 16 parts, Semen Sinapis Albae 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Zingiberis 10 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Radix Ophiopogonis 15 parts, Radix Peucedani 16 parts, Rhizoma Belamcandae 14 parts, Folium Perillae Frutescentis 16 parts, Flos Farfarae 18 parts, Radix Platycodonis 12 parts, Flos Chrysanthemi 10 parts, Radix Asteris 12 parts, Semen Sinapis Albae 10 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Zingiberis 8 parts and 6 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is made into capsule, tablet, powder, oral liquid, granule or pill.
Correspondingly, the present invention also provides the preparation method of described Chinese medicine composition, comprises following step:
(1): get Radix Ophiopogonis and clean, crushed after being dried, cross 60-80 mesh sieve, the coarse powder obtained is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): get Radix Peucedani, Rhizoma Belamcandae, Radix Asteris and Semen Sinapis Albae, clean, crushed after being dried, merge residue Radix Ophiopogonis, adding medical material gross weight 12-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 400-600W, and Extracting temperature is 40-60 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.20, obtained extract A;
(3): get Folium Perillae Frutescentis, Flos Farfarae, Radix Platycodonis, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Radix Glycyrrhizae, clean, crushed after being dried, merges with the medicinal residues in (2), adds the water soaking 30-60 minute of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-5 hour, filters, merging filtrate, filtrate reduced in volume to 60 DEG C relative density is 1.10-1.20 extractum, obtained extract B;
(4): merge Radix Ophiopogonis extract, extract A and extract B, drying under reduced pressure, pulverize, cross 80-100 mesh sieve, to obtain final product.
Source, the nature and flavor of the present invention's component used, return through and effect:
Radix Ophiopogonis: this product is the dried root of liliaceous plant Radix Ophiopogonis (dwarf lilyturf); Sweet in the mouth, micro-hardship, cold nature; GUIXIN, lung, stomach warp; YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.
Radix Peucedani: this product is the dry root of samphire Peucedanum praeruptorum DUNN or RADIX PEUCEDANI; Bitter in the mouth, pungent, cold nature; Return lung meridian; Loose wind heat clearing away, lowering the adverse-rising QI to resolve phlegm.
Rhizoma Belamcandae: this product is the dry rhizome of irides Rhizoma Belamcandae; Bitter in the mouth, cold in nature; Return lung meridian; Heat-clearing and toxic substances removing, expectorant, sore-throat relieving.
Folium Perillae Frutescentis: this product is the blade of labiate common perilla; Acrid in the mouth, warm in nature; Start with, meridian of Foot-TAI YIN; Induce sweat, cold expelling, regulates the flow of vital energy, and helps digestion.
Flos Farfarae: this product is the dry flower of feverfew coltsfoot; Acrid in the mouth, micro-hardship, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm.
Radix Platycodonis: this product is the dry root of Campanulaceae Radix Platycodonis; Bitter in the mouth, pungent, property is put down; Return lung meridian; Lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.
Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum
;sweet in the mouth, hardship, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.
Radix Asteris: this product is the dry root and rhizome of feverfew Radix Asteris; Acrid in the mouth is bitter, warm in nature; Return lung meridian; Nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.
Semen Sinapis Albae: this product is the seed of crucifer Caulis et Folium Sinapis albee; Acrid in the mouth, warm in nature; Return lung, liver, spleen, stomach, pericardium channel; Reduce phlegm by drink, mass dissipating and swelling eliminating.
Pericarpium Citri Reticulatae: this product is the dry mature skin of rutaceae orange and variety thereof; Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Rhizoma Zingiberis: this product is the dry rhizome of zingiber; Acrid in the mouth, hot in nature; Return spleen, stomach, kidney, the heart, lung meridian; Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
The prescription analysis of Chinese medicine of the present invention:
Chinese medicine composition prescription of the present invention is with Radix Ophiopogonis, Radix Peucedani and Rhizoma Belamcandae for monarch drug, lowering the adverse-rising QI to resolve phlegm, heat-clearing and toxic substances removing; With Folium Perillae Frutescentis, Flos Farfarae and Radix Platycodonis for ministerial drug, nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm, removing pathogenic heat from blood and toxic substance from the body, reconciling superficies and interior; With Flos Chrysanthemi, Radix Asteris, Semen Sinapis Albae, Pericarpium Citri Reticulatae and Rhizoma Zingiberis for adjuvant drug, stopping coughing and removing phlegm, reduces phlegm by drink, regulating qi-flowing for strengthening spleen; With Radix Glycyrrhizae for making medicine, invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription; The all medicines of monarch coordinate, and collaborative promotion, complements each other, finally reach relieving cough and resolving phlegm, depressed lung-energy dispersing, and effect of regulating qi-flowing for strengthening spleen and removing dampness appetizing, is used for the treatment of infantile common cold evident in efficacy.
Compared with prior art, the present invention has following technical advantage:
(1) animal experimental data shows, Chinese medicine composition of the present invention significantly can reduce the rat temperature that dry yeast causes rat fever, shows that Chinese medicine composition of the present invention has obvious cooling effect to heating; Clinical data shows, cure rate and the total effective rate of traditional Chinese medicine composition for treating infantile common cold of the present invention are higher, evident in efficacy;
(2) compared with the chemotherapeutic agent of current control infantile recurrent common cold, Chinese medicine composition of the present invention is natural pure Chinese medicine composition, untoward reaction and side effect significantly reduce, and effect comprehensively, medication effect is better, efficiently solve the morbidity root of infantile recurrent common cold, and improve the quality of life of patient;
(3) Chinese medicine composition of the present invention also has efficacy stability, preparation technology is simple, cost is low and be easy to advantages such as applying.
Therefore, the present invention's also application of claimed above-mentioned Chinese medicine composition in preparation treatment infantile recurrent common cold medicine.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the medical material of following weight portion: Radix Ophiopogonis 10 parts, Radix Peucedani 10 parts, Rhizoma Belamcandae 12 parts, Folium Perillae Frutescentis 12 parts, Flos Farfarae 12 parts, Radix Platycodonis 8 parts, Flos Chrysanthemi 8 parts, Radix Asteris 8 parts, Semen Sinapis Albae 8 parts, Pericarpium Citri Reticulatae 8 parts, Rhizoma Zingiberis 6 parts and 2 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1): get Radix Ophiopogonis and clean, crushed after being dried, cross 70 mesh sieves, the coarse powder obtained is placed in supercritical carbon dioxide extraction apparatus, 45% volume fraction adding coarse powder weight is the ethanol of 75%, regulation and control carbon dioxide flow is 15L/h, extracting pressure is 15MPa, and extraction temperature is 50 DEG C, and extraction time is 2h, decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(2): get Radix Peucedani, Rhizoma Belamcandae, Radix Asteris and Semen Sinapis Albae, clean, crushed after being dried, merge residue Radix Ophiopogonis, adding medical material gross weight 14 times amount volume fraction is the ethanol of 75%, microwave extraction 10 minutes, microwave power is 500W, and Extracting temperature is 50 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract A;
(3): get Folium Perillae Frutescentis, Flos Farfarae, Radix Platycodonis, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Radix Glycyrrhizae, clean, crushed after being dried, merges with the medicinal residues in (2), adds the water soaking 30 minutes of medical material gross weight 10 times amount, reflux, extract, 2 times, each 4 hours, filter, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10, obtained extract B;
(4): merge Radix Ophiopogonis extract, extract A and B, drying under reduced pressure, pulverize, cross 100 mesh sieves, obtain traditional Chinese medicine fine powder;
(5), toward the traditional Chinese medicine fine powder of (4) gained add suitable adjuvant, by the Chinese medicine preparation technology that the modern times are general, make oral liquid.
embodiment 2:
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the medical material of following weight portion: Radix Ophiopogonis 20 parts, Radix Peucedani 22 parts, Rhizoma Belamcandae 18 parts, Folium Perillae Frutescentis 20 parts, Flos Farfarae 24 parts, Radix Platycodonis 16 parts, Flos Chrysanthemi 14 parts, Radix Asteris 16 parts, Semen Sinapis Albae 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Zingiberis 10 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3:
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the medical material of following weight portion: Radix Ophiopogonis 15 parts, Radix Peucedani 16 parts, Rhizoma Belamcandae 14 parts, Folium Perillae Frutescentis 16 parts, Flos Farfarae 18 parts, Radix Platycodonis 12 parts, Flos Chrysanthemi 10 parts, Radix Asteris 12 parts, Semen Sinapis Albae 10 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Zingiberis 8 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
pharmacodynamic experiment
test example 1: Chinese medicine composition of the present invention causes the research experiment of rat fever impact to dry yeast
1, laboratory animal: level Wistar rat 96, male and female half and half, weight 220-280g, 18-24 week age.
2, Experimental agents: the oral liquid that the embodiment of the present invention 1, embodiment 2, embodiment 3 prepare; Positive control drug is XIAOER GANMAO KOUFUYE (Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory).
3, dry yeast causes rat fever: choose the comparatively constant rat of body temperature 96,12 groups are divided at random by weight, often organize 8, be respectively Normal group, model group, positive controls and the embodiment of the present invention 1, oral liquid basic, normal, high (2,4,8g/kg) dosage group prepared by embodiment 2, embodiment 3.First 1 day of administration, shaves hair by Wistar rat abdomen, and the same day was surveyed rat anus temperature 2-3 time in administration, got anus temperature based on its meansigma methods.Positive controls dosage is 8g/kg, normal group and model group gavage are to equal-volume normal saline, after each group of gastric infusion 30min, every rat is with 10ml/kg dorsal sc note 15% dry yeast suspension, Normal group is left intact, respectively at 2,4,6,8h measures anus temperature, records anus temperature changing value.
4, experimental result: in table 1.
Table 1 Chinese medicine composition of the present invention causes the impact of rat fever on yeast
Note: compare with Normal group,
△ △ p< 0.01,
△ △ △ p< 0.001; Compare with model control group,
* p< 0.05,
* p< 0.01,
* * p< 0.001; Compare with positive controls,
# p< 0.05.
From upper table 1, after subcutaneous injection dry yeast suspension, the anus temperature of rat raises gradually.Compare with Normal group, the anus temperature of model group rats extremely significantly increases (
p< 0.01), show modeling success; Compare with model group, Chinese medicine composition of the present invention high, medium and low dosage group and positive controls to heating rat all have significant refrigeration function (
p< 0.05), and sustainable 8h, wherein, Chinese medicine composition of the present invention presents good dose relationship; In addition, the high dose group of Chinese medicine composition of the present invention is significantly better than positive controls at the refrigeration function of 8h to heating rat.Above result shows, Chinese medicine composition of the present invention has obvious cooling effect to heating.
test example 2: Chinese medicine composition of the present invention is to the observation of curative effect of infantile recurrent common cold disease clinical volunteers patient
One, diagnostic criteria
Diagnostic criteria with reference to infantile common cold in Ministry of Health of the People's Republic of China's " influenza diagnosis and treatment standard and treatment guidelines (2011 editions) ":
1, heating, cough, watery nasal discharge, nasal obstruction and pharyngalgia, headache, there is myalgia, vomiting, diarrhoea in small part;
2, heating is light, moderate heat, without shivering;
3, without obvious General Symptoms.
Two, criterion of therapeutical effect
Efficacy assessment standard with reference to infantile common cold in Ministry of Health of the People's Republic of China's " influenza diagnosis and treatment standard and treatment guidelines (2011 editions) ":
Cure: the transference cures such as heating, cough, watery nasal discharge, nasal obstruction and pharyngalgia, feel comfortable;
Effective: the symptoms such as heating, cough, watery nasal discharge, nasal obstruction and pharyngalgia alleviate;
Invalid: after taking medicine, the state of an illness is without significant change.
Three, clinical trial
1, physical data
320 selected infantile common cold clinical volunteers patients are divided into 4 groups at random, often organize 80 people, be respectively matched group, treatment A group, treatment B group and treatment C group, the each group of influence factor such as age, symptom, through statistical procedures, there was no significant difference, meets a point set condition.
2, Therapeutic Method
Matched group: take XIAOER GANMAO KOUFUYE (Beijing Tongrentang Technology Development Co.ltd. Pharmaceutical Factory), a 10ml, 2 times on the one, serve on 4 weeks.
Treatment A, B and C group: take the oral liquid that the embodiment of the present invention 1,2,3 prepares respectively, every day 2 times, each 10ml, serve on 4 weeks;
3, therapeutic outcome
Table 2 therapeutic effect
From upper table 2, the curative effect of Chinese medicine composition in treatment infantile recurrent common cold prepared by preparation method of the present invention is better than positive controls, its cure rate reaches 80%, total effective rate reaches 90%, wherein best with the effect for the treatment of group C group and the embodiment of the present invention 3, cure rate reaches 90%, and total effective rate reaches 95%.Visible, Chinese medicine composition good effect prepared by the present invention, cure rate is high, and relapse rate is low, can as the drug use for the treatment of infantile recurrent common cold.
Claims (4)
1. prepare a method for the Chinese medicine composition of control infantile recurrent common cold, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps:
(1): take following raw material: Radix Ophiopogonis 10-20 part, Radix Peucedani 10-22 part, Rhizoma Belamcandae 12-18 part, Folium Perillae Frutescentis 12-20 part, Flos Farfarae 12-24 part, Radix Platycodonis 8-16 part, Flos Chrysanthemi 8-14 part, Radix Asteris 8-16 part, Semen Sinapis Albae 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Rhizoma Zingiberis 6-10 part and Radix Glycyrrhizae 2-10 part;
(2): get Radix Ophiopogonis and clean, crushed after being dried, cross 60-80 mesh sieve, the coarse powder obtained is placed in supercritical carbon dioxide extraction apparatus, the 30-45% volume fraction adding coarse powder weight is the ethanol of 60-85%, regulation and control carbon dioxide flow is 15-20L/h, extracting pressure is 15-20MPa, and extraction temperature is 40-60 DEG C, and extraction time is 1.5-2h, decompression separation obtains Radix Ophiopogonis extract, retains residue Radix Ophiopogonis;
(3): get Radix Peucedani, Rhizoma Belamcandae, Radix Asteris and Semen Sinapis Albae, clean, crushed after being dried, merge residue Radix Ophiopogonis, adding medical material gross weight 12-18 times amount volume fraction is the ethanol of 60-80%, microwave extraction 8-15 minute, microwave power is 400-600W, and Extracting temperature is 40-60 DEG C, filters and retains filtering residue, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.20, obtained extract A;
(4): get Folium Perillae Frutescentis, Flos Farfarae, Radix Platycodonis, Flos Chrysanthemi, Pericarpium Citri Reticulatae, Rhizoma Zingiberis and Radix Glycyrrhizae, clean, crushed after being dried, merges with the medicinal residues in (2), adds the water soaking 30-60 minute of medical material gross weight 8-12 times amount, reflux, extract, 2-3 time, each 3-5 hour, filters, merging filtrate, at filtrate reduced in volume to 60 DEG C, relative density is the extractum of 1.10-1.20, obtained extract B;
(5): merge Radix Ophiopogonis extract, extract A and extract B, drying under reduced pressure, pulverize, cross 80-100 mesh sieve, to obtain final product.
2. the method for the Chinese medicine composition of preparation control infantile recurrent common cold according to claim 1, it is characterized in that, in described Chinese medicine composition, the weight portion of each raw material is: Radix Ophiopogonis 10 parts, Radix Peucedani 10 parts, Rhizoma Belamcandae 12 parts, Folium Perillae Frutescentis 12 parts, Flos Farfarae 12 parts, Radix Platycodonis 8 parts, Flos Chrysanthemi 8 parts, Radix Asteris 8 parts, Semen Sinapis Albae 8 parts, Pericarpium Citri Reticulatae 8 parts, Rhizoma Zingiberis 6 parts and 2 parts, Radix Glycyrrhizae.
3. the method for the Chinese medicine composition of preparation control infantile recurrent common cold according to claim 1, it is characterized in that, in described Chinese medicine composition, the weight portion of each raw material is: Radix Ophiopogonis 20 parts, Radix Peucedani 22 parts, Rhizoma Belamcandae 18 parts, Folium Perillae Frutescentis 20 parts, Flos Farfarae 24 parts, Radix Platycodonis 16 parts, Flos Chrysanthemi 14 parts, Radix Asteris 16 parts, Semen Sinapis Albae 12 parts, Pericarpium Citri Reticulatae 12 parts, Rhizoma Zingiberis 10 parts and 10 parts, Radix Glycyrrhizae.
4. the method for the Chinese medicine composition of preparation control infantile recurrent common cold according to claim 1, it is characterized in that, in described Chinese medicine composition, the weight portion of each raw material is: Radix Ophiopogonis 15 parts, Radix Peucedani 16 parts, Rhizoma Belamcandae 14 parts, Folium Perillae Frutescentis 16 parts, Flos Farfarae 18 parts, Radix Platycodonis 12 parts, Flos Chrysanthemi 10 parts, Radix Asteris 12 parts, Semen Sinapis Albae 10 parts, Pericarpium Citri Reticulatae 10 parts, Rhizoma Zingiberis 8 parts and 6 parts, Radix Glycyrrhizae.
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| CN111228852A (en) * | 2020-01-16 | 2020-06-05 | 河北瑞龙生物科技有限公司 | Preparation method of aster keemun extract |
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| CN1724040A (en) * | 2005-07-14 | 2006-01-25 | 陕西容厦药业股份有限公司 | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1724040A (en) * | 2005-07-14 | 2006-01-25 | 陕西容厦药业股份有限公司 | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111228852A (en) * | 2020-01-16 | 2020-06-05 | 河北瑞龙生物科技有限公司 | Preparation method of aster keemun extract |
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Application publication date: 20160316 |