CN104587122A - Traditional Chinese medicine composition for treating chronic gastritis - Google Patents
Traditional Chinese medicine composition for treating chronic gastritis Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating chronic gastritis. The traditional Chinese medicine composition is prepared from the raw materials in parts by weight as follows: 20-50 parts of radix zanthoxyli, 20-40 parts of schefflera arboricola hayata, 10-30 parts of small centipeda herb, 10-30 parts of callicarpa macrophylla, 8-20 parts of rhizoma cyperi, 5-15 parts of rhizoma corydalis and 5-15 parts of liquorice. The traditional Chinese medicine composition has the effects for regulating stomach and removing painful abdominal mass, warming spleen and stomach for dispelling cold, invigorating the spleen and eliminating dampness, promoting blood circulation and removing stasis and promoting qi circulation and relieving pain; the symptoms of chronic gastritis as stuffy upper abdomen, pain, belching, dry mouth, noisy, pantothenic acid can be obviously improved for the patients, and the traditional Chinese medicine composition has little side effects and no untoward effect.
Description
Technical field
The invention belongs to medicine field, relate to a kind of Chinese medicine composition for the treatment of chronic gastritis.
Background technology
Modern owing to being busy with one's work, often staying up late, at ordinary times diet not note etc. reason causing the health of a lot of people to be all in sub-health state, as chronic gastritis.Chronic gastritis is common clinical, frequently-occurring disease, its etiology and pathogenesis is illustrated so far not yet completely, modern medicine is illustrated not yet about the cause of disease of chronic gastritis, think that its basic pathogenesis is peracid, helicobacter pylori, it is unbalance that immunity waits many factors to cause stomach to bore between the infringement of film and protection factor, based on symptomatic treatment in treatment, comprise antacid, anti-HP, strengthen mucous membrane protection, promote gastric peristalsis, reduce the hands sections such as Duodenal reflux, along with the appearance of various efficient antacid new drug, treatment chronic gastritis obtains good curative effect, but relapse rate still can be in any more, and majority has the medicine of definite curative effect, long-term taking has again many untoward reaction, so anxious to be developed go out one can ensure curative effect, relapse rate can be reduced again, and the medicine that untoward reaction is slight.Chinese medicine gastritis few side effects, not easily produces drug resistance, treating both the principal and secondary aspects of a disease, has unique advantage and potential.The present invention, through long term accumulation, works out a kind of Chinese medicine composition for the treatment of chronic gastritis, effectively can improve symptom, can reduce recurrence again, at present, there is not yet relevant report.
(1) Radix Zanthoxyli is the dry root of rutaceae Radix Zanthoxyli Zanthor μ lum nitidum (Roxb.) DC..Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are bitter, pungent, flat.Return liver, stomach warp.[function with cure mainly] blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, dispelling wind and removing obstruction in the collateral, removing toxic substances and promoting subsidence of swelling.For injury from falling down, stomachache, toothache, rheumatic arthralgia, venom; Externally treating burns and scalds.Modern study shows, the two sides crown is mainly containing containing the chemical compositions such as alkaloid, diosmin, coumarin, sterin, flavonoid glycoside, aminoacid.Radix Zanthoxyli Chinese medicine extract antiinflammatory, analgesia, anti-mattress, to cardiovascular system, spasmolytic, anticancer etc. in all have effect.
(2) Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), is Araliaceae Schefflera plant schefflera arboricola Scheffleva arboricola Hayata and Schefflera venulosa (Wight et Arn.) Harms S.venulosa (Wight et Arn.) Harms, is used as medicine with stem and leaf.Record in Chinese Pharmacopoeia version in 1977: [nature and flavor] acrid in the mouth; Micro-hardship; Warm in nature.[function with cure mainly] wind-expelling pain-stopping; Promoting blood circulation and detumescence.Main air pain of dampness syndrome; Headache; Toothache; Epigastric pain; Dysmenorrhea; Puerperal abdonimal pain; Treating swelling and pain by traumatic injury; Fracture; Skin ulcer swells.
(3) Herba Centipedae is the dry herb of feverfew Herba Centipedae Centipeda minima (L.) A.Br.et Aschers..Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are pungent, temperature.Return lung meridian.[function with cure mainly] dispersing wind-cold, clearing the nasal passage, cough-relieving.For headche due to wind-cold, cough with copious phlegm, has a stuffy nose obstructed, nasal sinusitis watery nasal discharge.
(4) Folium Callicarpae Macrophyllae is dried leaves or the band leaf twig of Verbenaceae Folium Callicarpae Macrophyllae Callicarpa macroph μ llaVahl.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are pungent, bitter, flat.Return liver, lung, stomach warp.[function with cure mainly] dissipating blood stasis stops blooding, reducing swelling and alleviating pain.For epistaxis, spitting of blood, spits blood, has blood in stool, traumatic hemorrhage, tumbling and swelling.
(5) Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] pungent, micro-hardship, micro-sweet, flat.Return liver, spleen, tri-jiao channel.[function with cure mainly] dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.
(6) Rhizoma Corydalis is the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang.Record in Chinese Pharmacopoeia version in 2010: [nature and flavor with return through] are pungent, bitter, temperature.Return liver, spleen channel.[function with cure mainly] invigorates blood circulation, circulation of qi promoting, pain relieving.For the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
(7) Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor with return through] are sweet, flat, GUIXIN, lung, spleen, stomach warp; [function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of chronic gastritis.
The technical solution adopted in the present invention is as follows:
Treat a Chinese medicine composition for chronic gastritis, raw material is made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 20-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20-40 part, Herba Centipedae 10-30 part, Folium Callicarpae Macrophyllae 10-30 part, Rhizoma Cyperi 8-20 part, Rhizoma Corydalis 5-15 part, Radix Glycyrrhizae 5-15 part.
The Chinese medicine composition of the above treatment chronic gastritis, raw material is preferably made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 30-40 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25-35 part, Herba Centipedae 15-25 part, Folium Callicarpae Macrophyllae 15-25 part, Rhizoma Cyperi 10-18 part, Rhizoma Corydalis 8-12 part, Radix Glycyrrhizae 8-12 part; Raw material the best is preferably made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 35 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30 parts, Herba Centipedae 20 parts, Folium Callicarpae Macrophyllae 20 parts, Rhizoma Cyperi 15 parts, Rhizoma Corydalis 10 parts, 10 parts, Radix Glycyrrhizae.
The Chinese medicine composition of the above treatment chronic gastritis, acceptable excipient on various pharmaceuticss required when preparing different dosage form can be added, as disintegrating agent, lubricant, binding agent, cosolvent, thickening agent, antiseptic etc., and be prepared into pharmaceutically acceptable any dosage form with modern Chinese medicine formulation method.Such as, be mixed and made into powder after each raw material of Chinese medicine directly can being pulverized; Also by these crude drug water or with processing accordingly after ethanol extraction and adding the different auxiliary material needed for the different solid preparation of preparation, the day oral solid preparation that capsule, tablet, pill, powder, drop pill, granule etc. are multi-form can namely be can be made into; Also by these crude drug water or with processing accordingly after ethanol extraction and adding the different auxiliary material prepared needed for different liquids preparation, the oral liquid that mixture, syrup, Emulsion etc. are multi-form can namely be can be made into.As preferably, described dosage form is capsule.
The Chinese medicine composition of the above treatment chronic gastritis makes the preparation method of capsule, comprises the following steps:
1. take component respectively by weight: Radix Zanthoxyli 20-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20-40 part, Herba Centipedae 10-30 part, Folium Callicarpae Macrophyllae 10-30 part, Rhizoma Cyperi 8-20 part, Rhizoma Corydalis 5-15 part, Radix Glycyrrhizae 5-15 part;
2. get Rhizoma Corydalis and be ground into fine powder, cross 80 mesh sieves, obtain first English white;
3. get Herba Centipedae, Rhizoma Cyperi extracts volatile oil, for subsequent use; Medicinal residues and Radix Zanthoxyli, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Folium Callicarpae Macrophyllae, Radix Glycyrrhizae, add 6-10 times of water gaging, heating extraction 2-3 time, each 1-2 hour, and filter, merging filtrate, filtrate is condensed into thick paste, and add the first English white under step 2 and appropriate amount of starch, dry, pulverize, get dry extract powder;
4. get the volatile oil under step 3, with 6-10 times amount betacyclodextrin inclusion his cyclodextrin inclusion complex at double, add in step 3 dried cream powder, add magnesium stearate, microcrystalline Cellulose, mixing, incapsulates, to obtain final product.
Chinese medicine composition of the present invention is made up of Radix Zanthoxyli, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Centipedae, Folium Callicarpae Macrophyllae, Rhizoma Cyperi, Rhizoma Corydalis, Radix Glycyrrhizae, all medicines are harmonious, gather altogether and diabetes involving middle-JIAO painful abdominal mass, warming spleen and stomach for dispelling cold, the spleen strengthening and damp drying, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain merit, there is well treatment gastritis effect.The consumption of pharmaceutical composition of the present invention is also through inventor and gropes in a large number to sum up, repeatedly study and verify preferably and obtain, show through clinical trial: the present invention treats chronic gastritis significant curative effect, effective percentage reaches 95%, can obviously improve patient's epigastrium full vexed, pain, belch, xerostomia, noisy, pantothenic acid, weak, become thin, the symptom such as lack of appetite, and side effect is little, during medication, there is not the untoward reaction such as gastrointestinal tract, allergy.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
The Chinese medicine composition of one, treating chronic gastritis makes the preparation method of capsule
1. EXPERIMENTAL DESIGN:
This test 5 embodiments are prepared into capsule respectively, and design parameter refers to table 1.
Table 1 capsule embodiment preparation parameter table
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| Radix Zanthoxyli (kg) | 20 | 50 | 40 | 30 | 35 |
| Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) (kg) | 20 | 40 | 35 | 25 | 30 |
| Herba Centipedae (kg) | 10 | 30 | 25 | 15 | 20 |
| Rhizoma Cyperi (kg) | 8 | 20 | 18 | 10 | 15 |
| Folium Callicarpae Macrophyllae (kg) | 10 | 30 | 25 | 15 | 20 |
| Rhizoma Corydalis (kg) | 5 | 15 | 12 | 8 | 10 |
| Radix Glycyrrhizae (kg) | 5 | 15 | 12 | 8 | 10 |
| Extract amount of water (doubly) | 6 | 8 | 10 | 7 | 8 |
| Extraction time (secondary) | 3 | 2 | 2 | 3 | 2 |
| Time (h/ time) | 1 | 2 | 1.5 | 1 | 2 |
| Relative density (60 DEG C) | 1.25 | 1.28 | 1.26 | 1.32 | 1.30 |
| Betacyclodextrin amount (doubly) | 6 | 8 | 7 | 8 | 6 |
2. operating procedure:
(1) take respectively by table 1 weight portion: Radix Zanthoxyli, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Centipedae, Folium Callicarpae Macrophyllae, Rhizoma Cyperi, Rhizoma Corydalis, Radix Glycyrrhizae;
(2) get Rhizoma Corydalis and be ground into fine powder, cross 80 mesh sieves, obtain first English white;
(3) get Herba Centipedae, Rhizoma Cyperi extracts volatile oil, for subsequent use; Medicinal residues and Radix Zanthoxyli, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Folium Callicarpae Macrophyllae, Radix Glycyrrhizae, add 6-10 times of water gaging, heating extraction 2-3 time, each 1-2 hour, filters, merging filtrate, filtrate is condensed into the thick paste that relative density is 1.25 ~ 1.32 (60 DEG C), adds the first English white under step (2) and appropriate amount of starch, dry, pulverize, get dry extract powder;
(4) get the volatile oil under step (3), with 6-10 times amount betacyclodextrin inclusion his cyclodextrin inclusion complex at double, add in step (3) dried cream powder, add magnesium stearate, microcrystalline Cellulose, mixing, incapsulates, to obtain final product.
Three, clinical practice
1. case selection standard
All cases all meet the diagnostic criteria that digestive endoscopy branch of Chinese Medical Association works out " the endoscopic classification grade scale of chronic gastritis and the tentative suggestion for the treatment of " in 2003.
(1) clinical cardinal symptom: the epigastrium of prolonged and repeated generation full vexed, pain, belch, xerostomia, noisy, pantothenic acid.Have a medical check-up and can have the mild tenderness of epigastrium, without muscle tonus and rebound tenderness.
(2) gastroscope prompting has superficial gastritis or erosive gastritis or reflux gastritis.
(3) inclusive criteria:
A. the age is between 18-65 year.
B. before medication, 1-2 week is interior through gastroscope, pathologic finding prover.
C. can partner treatment, the patient of further consultation on time.
(4) exclusion standard
A. the age is under-18s or over-65s person.
B. peptic ulcer is merged, digestive system carcinoma, the doubtful person of cancerating of pathological diagnosis.
C. severe primary disease, the abdominal operations such as Progressive symmetric erythrokeratodermia scleroderma, the heart, cerebrovascular, Liver and kidney and hemopoietic system is merged, psychotic.
D. gestation or preparation gravid woman, women breast-feeding their children.
E. allergic constitution or to multi-medicament allergy sufferers.
F. not by regulation medication or therapy discontinued, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
2. therapeutic scheme
(1) embodiment group: by above-mentioned embodiment 5 sample prepared, for clinical trial.Oral, one time 5,3 times on the one.The course for the treatment of: medication 45 days.
(2) matched group: cubic stomach sheet (commercially available).Oral, one time 3,3 times on the one.The course for the treatment of: medication 45 days.
3. efficacy assessment standard
Integration × 100% before therapeutic index=(treat front integration one and treat rear integration)/treatment
(1) fully recover: clinical cardinal symptom disappears or substantially disappears, therapeutic index >=95%; Gastroscopy ulcer and around inflammation all disappear, and are cicatrix.
(2) improve: clinical cardinal symptom take a favorable turn, therapeutic index >=30%; Gastroscopy ulcer surface reduces more than 50%.
(3) invalid: clinical cardinal symptom without improvement, therapeutic index < 30%; Gastroscopy ulcer surface reduces not as good as 50%.
4. result of the test: be used for the treatment of and observe 70 routine outpatients.By above-mentioned embodiment 5 sample for preparing and cubic stomach sheet, be respectively used to patient: treatment group: 40 examples (man 18 example, female 22 example, 40.6 years old mean age), matched group 30 example (man 13 example, female 17 example, 41.8 years old mean age), the results detailed in Table 2.
Table 2 clinical trial result table
Result shows: adopt the embodiment of the present invention 5 to treat, cure rate is 75%, effective percentage reaches 95%, general effect is suitable with matched group, untoward reaction is not had to occur, use safety, effectively, can obviously improve patient's epigastrium full vexed, pain, belch, xerostomia, noisy, pantothenic acid, weak, become thin, the symptom such as lack of appetite, favourable prognosis.Be below several model case:
Case 1: Yuan's ××, female, 32 years old, epigastrium was glutted, dull pain, belch acid regurgitation.Gastroscopy gastric mucosa is congested.Take the embodiment of the present invention 5, each 5, every day 3 times, take 5, dull pain symptom is eliminated, and take 10, glutted, belch acid regurgitation symptom is obviously improved, and serve on 45, transference cure, recovery from illness.Pay a return visit after 1 year, have no recurrence.
Case 2: execute ××, man, 45 years old, before or after meals stomach dull pain, existing half a year, hospital gastroscope check result: superficial gastritis.Take the embodiment of the present invention 5, each 5, every day 3 times, serve on 45, gastritis transference cure, recovery from illness.Pay a return visit after 1 year, have no recurrence.
Case 3: Dong's ××, man, 38 years old, epigastrium pain, abdominal distention, vomiting, weak, become thin.Gastroscopy, gastric mucosa is congested, ulcer.Take the embodiment of the present invention 5, each 5, every day 3 times, serve on 45, above symptom is eliminated, gastroscopy, has no stomach congested and rotten to the corn, recovery from illness.Pay a return visit after 1 year, have no recurrence.
Claims (6)
1. treat the Chinese medicine composition of chronic gastritis for one kind, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 20-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20-40 part, Herba Centipedae 10-30 part, Folium Callicarpae Macrophyllae 10-30 part, Rhizoma Cyperi 8-20 part, Rhizoma Corydalis 5-15 part, Radix Glycyrrhizae 5-15 part.
2. treat the Chinese medicine composition of chronic gastritis according to claim 1, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 30-40 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 25-35 part, Herba Centipedae 15-25 part, Folium Callicarpae Macrophyllae 15-25 part, Rhizoma Cyperi 10-18 part, Rhizoma Corydalis 8-12 part, Radix Glycyrrhizae 8-12 part.
3. treat the Chinese medicine composition of chronic gastritis according to claim 1, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Zanthoxyli 35 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30 parts, Herba Centipedae 20 parts, Folium Callicarpae Macrophyllae 20 parts, Rhizoma Cyperi 15 parts, Rhizoma Corydalis 10 parts, 10 parts, Radix Glycyrrhizae.
4. treat the Chinese medicine composition of chronic gastritis according to claim 1, it is characterized in that, described Chinese medicine composition is prepared into pharmaceutically acceptable any dosage form.
5. treat the Chinese medicine composition of chronic gastritis according to claim 4, it is characterized in that, described dosage form is capsule.
6. the Chinese medicine composition for the treatment of chronic gastritis as claimed in claim 1 makes a preparation method for capsule, it is characterized in that, comprises the following steps:
(1) component is taken respectively by weight: Radix Zanthoxyli 20-50 part, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 20-40 part, Herba Centipedae 10-30 part, Folium Callicarpae Macrophyllae 10-30 part, Rhizoma Cyperi 8-20 part, Rhizoma Corydalis 5-15 part, Radix Glycyrrhizae 5-15 part;
(2) get Rhizoma Corydalis and be ground into fine powder, cross 80 mesh sieves, obtain first English white;
(3) get Herba Centipedae, Rhizoma Cyperi extracts volatile oil, for subsequent use; Medicinal residues and Radix Zanthoxyli, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Folium Callicarpae Macrophyllae, Radix Glycyrrhizae, add 6-10 times of water gaging, heating extraction 2-3 time, each 1-2 hour, and filter, merging filtrate, filtrate is condensed into thick paste, and add the first English white under step (2) and appropriate amount of starch, dry, pulverize, get dry extract powder;
(4) get the volatile oil under step (3), with 6-10 times amount betacyclodextrin inclusion his cyclodextrin inclusion complex at double, add in step (3) dried cream powder, add magnesium stearate, microcrystalline Cellulose, mixing, incapsulates, to obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107898907A (en) * | 2017-12-29 | 2018-04-13 | 广西万德药业有限公司 | Treat capsule of acute or chronic gastritis and preparation method thereof |
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| CN1695691A (en) * | 2005-05-24 | 2005-11-16 | 梅广源 | Medication for treating ulcer disease, gastritis, stomachache, abdominal pain |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1695691A (en) * | 2005-05-24 | 2005-11-16 | 梅广源 | Medication for treating ulcer disease, gastritis, stomachache, abdominal pain |
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| 单兆伟: "胃痛辩证论治106例分析", 《南京中医学院学报》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107898907A (en) * | 2017-12-29 | 2018-04-13 | 广西万德药业有限公司 | Treat capsule of acute or chronic gastritis and preparation method thereof |
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