Summary of the invention
At the problems referred to above that prior art exists, the technical problem to be solved in the present invention is: how a kind of medicinal ingredient compatibility treatment gynaecopathia washing liquid reasonable, evident in efficacy, that can not have side effects to the women and preparation method thereof is provided.
Solve this technical problem, the present invention is achieved in that a kind of washing liquid for the treatment of gynaecopathia, it is characterized in that, mainly by in medicinal composition add water and boil and form, wherein, Chinese medicine ingredients is made up of following medicaments in part by weight: Rhizoma Coptidis 0.5-3, Radix Sophorae Flavescentis 2-6, Cortex Phellodendri 1.5-5, Fructus Cnidii 1-4, Pericarpium Zanthoxyli 0.5-3 and Radix Stemonae 0.5-3.
Further, described washing liquid comprises that also weight portion is that the Mentholum of 0.05-0.06, chlorhexidine acetate and the weight portion that weight portion is 0.1-0.5 are the sodium benzoate of 0.03-0.06.
As the further optimization of technique scheme, the weight proportion of described each composition of washing liquid is: Rhizoma Coptidis 0.7-2.5, Radix Sophorae Flavescentis 3-5, Cortex Phellodendri 2.5-4, Fructus Cnidii 1.8-3, Pericarpium Zanthoxyli 1-2, Radix Stemonae 1-2, Mentholum 0.05-0.06, chlorhexidine acetate 0.2-0.4 and sodium benzoate 0.03-0.06.
As the optimal case of technique scheme, the weight proportion of described each composition of washing liquid is: Rhizoma Coptidis 1.5, Radix Sophorae Flavescentis 4, Cortex Phellodendri 3.5, Fructus Cnidii 2.5, Pericarpium Zanthoxyli 1.5, the Radix Stemonae 1.5, Mentholum 0.055, chlorhexidine acetate 0.35 and sodium benzoate 0.05.
The side separates: we are principal agent with the Rhizoma Coptidis, heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, the conjunctival congestion acid regurgitation, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated, parasite killing.
Rhizoma Coptidis is that " herbal classic " is top grade.Original text: bitter in the mouth is cold.Main steam, the ophthalmalgia corner of the eyes is hindered delacrimation, makes eye bright, and the intestinal Bleach diarrhea of suffering from abdominal pain swells and ache in married woman's the moon.Rhizoma Coptidis is fried in shallow oil the infectious disease that the soup washout not only can be used for eye, also can treat for the infectious disease at other positions, and Rhizoma Coptidis is singly fried in shallow oil washout and can treat in married woman's the moon and swell and ache, i.e. illness such as the pruritus vulvae due to the damp invasion of lower energizer, vaginitis.If with compatibilities such as Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, the Radix Stemonae, Pericarpium Zanthoxyli, heat-clearing and toxic substances removing, the reducing swelling and alleviating pain curative effect is then better.
Rhizoma Coptidis has tangible analgesia and antiinflammatory action, and staphylococcus aureus, vibrio cholera, group B streptococcus are had stronger bacteriostasis, and escherichia coli, Bacillus typhi are also had certain bacteriostasis; Important active component matrine has apparent inhibitory action to the multidirectional hemopoietic progenitor cell colony of chronic myelocytic leukemia periphery generation rate in the Radix Sophorae Flavescentis, suppression ratio reaches 0.76, Radix Sophorae Flavescentis decocting liquid acts on the human promyelocytic leukemia cell of In vitro culture, can show the inducing leukemia cell that lands breaks up to the mononuclear phagocyte direction, matrine can also reduce the release of sensitive media simultaneously, had certain anti-allergic effects; The Cortex Phellodendri antibiotic effective ingredient is berberine, it all has stronger inhibitory action to staphylococcus aureus, streptococcus pneumoniae, diphtheria corynebacterium, Streptococcus viridans, dysentery bacterium, Hemolytic streptococcus, meningococcus, vibrio cholera, anthrax bacillus, and trichomonas vaginitis is also had certain effect; Fructus Cnidii has stronger effect to vulval eczema, married woman's pudendal pruritus, trichomonal vaginitis; Pericarpium Zanthoxyli is to 10 kinds of gram positive bacterias such as anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and Staphylococcus albus, bacillus subtilis, and enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have the obvious suppression effect, but also can external treatment eczema pruritus; The Radix Stemonae is to various pathogens, especially to streptococcus pneumoniae, beta hemolysis type streptococcus, meningococcus, staphylococcus aureus, Staphylococcus albus and dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, Bacillus proteus, diphtheria corynebacterium, pneumobacillus, bacillus pestis, anthrax bacillus, bacillus subtilis, and vibrio cholera has stronger bacteriostasis; Mentholum is a kind of aromatic drug, remedium corrigens and carminative, can be used for skin or mucosa and produces refrigerant sense to alleviate discomfort and pain; Chlorhexidine acetate is cationic surfactant, has antibacterial action, and most Grain-positives and negative bacteria are had killing action, and is also effective to bacillus pyocyaneus.
A kind of preparation method of washing liquid for the treatment of gynaecopathia is characterized in that, comprises the steps:
Step 1 takes by weighing Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, Pericarpium Zanthoxyli and the Radix Stemonae by the weight proportion of each described each composition of washing liquid of claim 2-4;
Step 2 adds described Chinese medicine ingredients gross weight 8-10 water doubly as solvent, decocts 1.5 hours, and the filter liquor body portion is stand-by;
Step 3 adds the weight 6-8 water doubly of the filtering residue that leaches through step 2 as solvent, decocts 1 hour, and the filter liquor body portion is stand-by;
Step 4 adds the weight 6-8 water doubly of the filtering residue that leaches through step 3 as solvent, decocts 40 minutes, and the filter liquor body portion is stand-by;
Step 5, the filtrate merging with step 2, step 3 and step 4 gained stirs;
Step 6, the filtrate that step 5 is obtained concentrates, and the relative density with respect to 60 ℃ of water after concentrating is the clear paste of 1.20-1.25;
Step 7 obtains adding ethanol in the clear paste to step 6, the weight of ethanol is accounted for add 60% ~ 70% of clear paste gross weight behind the ethanol, leave standstill 24 hours after, filter ethanol reclaimed;
Step 8 adds the water of 5L-250L in the clear paste of handling through step 7, adds Mentholum, chlorhexidine acetate and sodium benzoate again and stirs, and filters after the sterilization namely.
Relative prior art, the present invention has following advantage:
The present invention is complete, and the side is made up of medicines such as Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Phellodendri, Fructus Cnidii, Pericarpium Zanthoxyli, the Radixs Stemonae, Rhizoma Coptidis, Cortex Phellodendri heat clearing and damp drying, detoxifcation in the side, Radix Sophorae Flavescentis, Fructus Cnidii, Pericarpium Zanthoxyli, Radix Stemonae killing parasites for relieving itching.
The function of this washing liquid: heat-clearing and toxic substances removing, anti-inflammation, removing dampness and killing parasites is antipruritic, is applicable to the damp heat downward flowing type pruritus vulvae, and vulval eczema reaches infusorian property, colpitis mycotica.To the microbial vaginitis that causes a disease because of antibacterial, mycete, fungus, infusorian etc., vulvitis is evident in efficacy, and can keep normal intravaginal environment, enhancing body is resisted the ability of all kinds of pathogenic bacterium invasion and attack, rapid-action, nonirritant and sensitization, with after feel more lubricated pleasant, the crowd who is suitable for each age group can be used for the sterilization of disease treatment and daily cleaning for a long time.
Studies have shown that according to existing bacteriostatic test: staphylococcus aureus, escherichia coli, Candida albicans (mycete) pathogenic microbes of etc.ing are had 100% antibacterial (sterilization) and act on.
The present invention is based on motherland's medical science to understanding and the Therapeutic Principle of gynaecopathia, forms in conjunction with modern pharmacological research and clinical practice experience prescription, and be foundation with ancient literature research, prompting gynaecopathia deficiency in origin and excess in superficiality.The deficiency in origin person is positive QI-insufficiency, caused by liver and kidney deficiency; Marking real person, is that the stasis of blood, heat, wet three accumulate among the born of the same parents, and QI-blood circulation is not smooth, and collaterals of the uterus is obstructed, stagnation of QI and blood may bring about pain.The present invention just is being based on this, and the Chinese medicine compound washing liquid of the gynaecopathia of development treatment targetedly is used for the treatment of various gynecological diseases.
Its medicinal ingredient substantially all is Chinese medicine ingredients, compatibility is reasonable, fried good before packing, very easy to use, simultaneously owing to do not contain a large amount of sanitizer chemical in the composition of washing liquid, less to the human body damage, sodium benzoate has the human body detoxicating functions, and the interpolation of appropriateness can also further reduce medicine to the infringement of human body; In addition owing to do not contain antibiotic in the composition of this washing liquid, this washing liquid of life-time service can not produce the self-cleaning and defence capability that can not destroy vagina, pathogen bacterium biologies such as staphylococcus aureus, Candida albicans, novel candidiasis, Pseudomonas aeruginosa, group B streptococcus, bacillus pyocyaneus, escherichia coli, yeast and infusorian are developed immunity to drugs, the treatment of gynecological inflammation is had better curative effect.
Technological process advanced person of the present invention, the control steady quality is reliable.
The specific embodiment
Below the washing liquid of in conjunction with the embodiments the present invention being treated gynaecopathia is described in further detail.
Embodiment 1: a kind of washing liquid for the treatment of gynaecopathia prepares by following concrete steps:
Step 1 takes by weighing Rhizoma Coptidis 1.5kg, Radix Sophorae Flavescentis 4.0kg, Cortex Phellodendri 3.5kg, Fructus Cnidii 2.5kg, Pericarpium Zanthoxyli 1.5kg, Radix Stemonae 1.5kg;
Step 2 adds the crude drug weight 8-10 water doubly of described component as solvent, decocts 1.5 hours, and the filter liquor body portion is stand-by;
Step 3 adds the weight 6-8 water doubly of the filtering residue that leaches through step 2 as solvent, decocts 1 hour, and the filter liquor body portion is stand-by;
Step 4 adds the weight 6-8 water doubly of the filtering residue that leaches through step 3 as solvent, decocts 40 minutes, and the filter liquor body portion is stand-by;
Step 5, the filtrate merging with step 2, step 3 and step 4 gained stirs;
Step 6, the filtrate that step 5 is obtained concentrates, and the relative density with respect to 60 ℃ of water after concentrating is the clear paste of 1.20-1.25;
Step 7 obtains adding ethanol in the clear paste to step 6, the weight of ethanol is accounted for add 60% ~ 70% of clear paste gross weight behind the ethanol, leave standstill 24 hours after, filter ethanol reclaimed;
Step 8 adds the water of 80L in the clear paste of handling through step 7, adds 0.055kg Mentholum, 0.35kg chlorhexidine acetate and 0.05kg sodium benzoate again and stirs, and filters after the sterilization namely.
Below be embodiment 2-5, among the embodiment 2-6, the proportion relation of each composition is as described in Table 1, and the method for preparing washing liquid according to the proportion relation of embodiment 2-5 is identical with embodiment 1; The method for preparing washing liquid according to the proportion relation of embodiment 6 is identical with embodiment 1 preparation method step 1-7, and step 8 difference, difference only are not add Mentholum, chlorhexidine acetate and three kinds of compositions of sodium benzoate.
Table 1
Raw material |
Embodiment 2 |
Embodiment 3 |
Embodiment 4 |
Embodiment 5 |
Embodiment 6 |
Rhizoma Coptidis (kg) |
0.5 |
0.7 |
2.5 |
3.0 |
1.5 |
Radix Sophorae Flavescentis (kg) |
2.0 |
3.0 |
5.0 |
6.0 |
4.0 |
Cortex Phellodendri (kg) |
1.5 |
2.5 |
4.0 |
5.0 |
3.5 |
Fructus Cnidii (kg |
1.0 |
1.8 |
3.0 |
4.0 |
2.5 |
Pericarpium Zanthoxyli (kg) |
0.5 |
1.0 |
2.0 |
3.0 |
1.5 |
The Radix Stemonae (kg) |
0.5 |
1.0 |
2.0 |
3.0 |
1.5 |
Mentholum (kg) |
0.02 |
0.05 |
0.06 |
0.08 |
0 |
Chlorhexidine acetate (kg) |
0.1 |
0.2 |
0.4 |
0.5 |
0 |
Sodium benzoate (kg) |
0.02 |
0.03 |
0.06 |
0.08 |
0 |
Water (L) |
10 |
50 |
150 |
250 |
80 |
At above-described embodiment 1-5, clinical experiment is observed in 100 examples and is suffered from the operating position of one or more patients in damp heat downward flowing type pruritus vulvae, vulval eczema, trichomonal vaginitis, the colpitis mycotica.Therapeutic process is to use every day the said medicine washing liquid to wash or the direct drug injection cotton embrocates twice, or with the dilution of eliminating cold for resuscitation water, demibain or flushing, treatment cycle 15 days.
Criterion of therapeutical effect:
1, recovery from illness: inflammation and eczema disappear, and scratchiness disappears, and leucorrhea amount and recovering state are normal;
2, effective: inflammation and eczema disappear substantially, and scratchiness disappears substantially, and leucorrhea amount and state recover normal substantially;
3, slightly produce effect: inflammation and eczema have improvement, and scratchiness has and alleviates, and the leucorrhea amount reduces;
4, invalid: all less than taking a turn for the better, scratchiness does not alleviate for inflammation and eczema, and leucorrhea amount and state do not improve;
Therapeutic outcome: as table 2
Table 2
? |
Recovery from illness (example) |
Effectively (example) |
(example) slightly produces effect |
Invalid (example) |
Embodiment 1 |
68 |
17 |
10 |
0 |
Embodiment 2 |
55 |
30 |
14 |
1 |
Embodiment 3 |
62 |
16 |
12 |
0 |
Embodiment 4 |
65 |
22 |
11 |
2 |
Embodiment 5 |
59 |
25 |
12 |
4 |
Embodiment 6 |
66 |
18 |
11 |
0 |
The present invention compares with similar gynecopathy external use cleaning liquid product, and its good effect is applied widely, and this product has antibacterial (sterilization) effect of 100 ﹪ to pathogenic microbes such as staphylococcus aureus, escherichia coli, Candida albicans.
The present invention treat gynaecopathia washing liquid staphylococcus aureus, Candida albicans, group B streptococcus, bacillus pyocyaneus, escherichia coli, yeast and trichomoniasis substance are had extraordinary sterilization and fungistatic effect, simultaneously germ pruritus vulvae, trichomonal vaginitis, colpitis mycotica because of such property are also had curative effect very.According to the relevant knowledge of prior art as can be known washing liquid of the present invention other similar pathogen mushrooms and the gynecological inflammation that causes thereof are also had certain therapeutic effect.Medicine of the present invention can be made into the bottle/bag dress of different size, compared with similar products under, the daily hygiene of, skin outer to intravaginal, the mucosa antibacterial good effect that keeps healthy, wide accommodation, the storage that is easy to carry, this product reaches the top standard on the market at home.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can make amendment or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.