CN106619238A - Composition for treating chloasma - Google Patents

Composition for treating chloasma Download PDF

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Publication number
CN106619238A
CN106619238A CN201610974888.8A CN201610974888A CN106619238A CN 106619238 A CN106619238 A CN 106619238A CN 201610974888 A CN201610974888 A CN 201610974888A CN 106619238 A CN106619238 A CN 106619238A
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parts
chloasma
cosmetics
weight
component
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徐雪灵
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
    • A61K8/585—Organosilicon compounds
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract

The invention discloses a composition for treating chloasma, and belongs to the field of whitening and freckle removing. The composition for treating the chloasma comprises internal medicines, external medicines and external cosmetics. The internal medicines comprise, by weight, margarita powder, radix glycyrrhizae, fructus corni, poria, radix angelicae sinensis, radix angelicae dahuricae, flos carthami, radix paeoniae alba and rhizoma dioscoreae; the external medicines comprise, by weight, stripping agents, titanium dioxide and miconazole nitrate; the external cosmetics comprise, by weight, main phases, auxiliary phases, water phases, oil phases, auxiliaries and pH (potential of hydrogen) regulators. The composition has the advantages that the composition is reasonable in compatibility and free of toxic and side effects; the internal medicines are used for activating blood, dissolving stasis, enhancing the immunity of organisms and improving facial pigmentation; the external medicines are used for removing the chloasma formed on faces; the external cosmetics are used for whitening and fading the chloasma.

Description

For treating the compositionss of chloasma
Technical field
The present invention relates to whitening and speckle dispelling field, particularly relates to a kind of compositionss for treating chloasma.
Background technology
Chloasma is commonly called as " butterfly spot ", " chloasma hepaticum " or " cyasma ".Occur mainly in face, with cheekbone portion, buccal, nose, Based on forehead, chin portion.The patch of brown or black for obscure boundary Chu, mostly symmetry.The appearance of chloasma it is most with it is interior Secretion it is relevant, it is especially relevant with the estrogen level of women, menoxenia, gestation, take contraceptive or liver function it is bad and Chronic nephropathy is all likely to occur chloasma.In addition Exposure to Sunlight and Nervous and Mental Factors can also increase primary disease.Anemia of pregnant woman usually gestation 3 months with After there is chloasma, majority are gradually disappeared when menstruation recovery is normal after childbirth.If do not moved back for a long time, needs are treated.
Chloasma is a kind of common skin pigment obstacle disease, and its pathogenic factor is a lot, wherein having endogenous cause of ill and exopathogenic factor Main two factors, endogenous cause of ill includes：Skin pigment, internal acid base imbalance, endocrine disturbance, stress, pathological factor are (chronic Disease and viscera function obstacle disease etc.).Exopathogenic factor includes：Ultraviolet, life stress, medicine effect, chemical substance, external force are rubbed Wiping, cosmetic method, electromagnetic radiation etc., the emotion significant fluctuations that a series of family, society, work, cause are caused, air ambient Pollution, the folding TYR enzyme that ultraviolet impact is irradiated and produced causes and obtains.The serious physical beauty for affecting people.Chloasma Once forming most people enters vicious cycle.At present both at home and abroad the technology and cosmetics for the treatment of chloasma are a lot, either swash Light, the face mask of traditional Chinese medicine or light speckle effect of cosmetics is not ideal to be particularly easy to bounce-back, what is had does not just come out or occurs at all More speckle dispelling, the more situations of speckle.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of compatibility rationally, has no toxic side effect, and can thoroughly dispel yellowish-brown The compositionss of speckle.
To solve above-mentioned technical problem, it is as follows that the present invention provides technical scheme：
On the one hand, there is provided a kind of cosmetics for desalinating chloasma, including the component of following weight portion：Principal phase 2.253～7.35 parts, 2.39～18.3 parts of auxiliary phase, 55.18～82.5 parts of water phase, 2.12～23 parts of oil phase, 0.2～2 part of auxiliary agent And 0.1～1 part of pH adjusting agent.
Further, the principal phase includes the component of following weight portion：0.8～3 part of Chondrus crispus extract, glycine betaine 0.04～2 part, 0.003～0.9 part of butanediol, 0.08～0.3 part of AVC, oxybenzene first 0.01～0.15 part of ester, 0.6～1 part of carbomer.Wherein：Chondrus crispus extract be from natural seaweed extract moisturizing into Point, it is used to help skin and improves moisture and moisturizing degree；Glycine betaine is a kind of composition extracted from Radix Betae, can be played well Cleaning action, and skin is not injured, it is very safe；Butanediol is commonly used for wetting agent in cosmetics and solvent is used, and is protecting Wet aspect, butanediol is small molecule moisturizing ingredient, while with certain bacteriostasis；Ammonium acryloyldime-thyltaurate/VP Copolymer is used in cosmetics as a kind of macromolecule surfactant as thickening agent；Methyl hydroxybenzoate Main Function has food Product, cosmetics, the sterilization antiseptic of medicine；Carbomer is in cosmetics as thickening agent.
Further, the auxiliary phase includes the component of following weight portion：0.01～2 part of Glycyrrhiza glabra L. root extract, anti-ring 0.2～3 part of hematic acid sodium phosphate, 0.03～2 part of ubiquinone, 2～11 parts of glutathion, 0.15～0.3 part of HSPC. Wherein：Glycyrrhiza glabra L. root extract, is the stem of certain species or Glycyrrhiza glabra L. (Glycyrrhiza glabra L).Glycyrrhiza glabra L. Extract can go deep into skin inside and keep high activity, effectively suppress various enzymes in melanin generating process (such as to suppress L-Tyrosine Enzyme) activity, be a kind of fast, efficient, safe, green whitening cosmetics additive.While Glycyrrhiza glabra L. extract Also have functions that to prevent pachylosiies and antiinflammatory, antibacterial；Ascorbic acid sodium phosphate is adjusted in cosmetics as a kind of skin Reason agent；Ubiquinone is exempted from as a kind of fat-soluble antioxidant, the nutrition of energy human activin cell and cellular energy with human body is improved The functions such as epidemic disease power, enhancing antioxidation, slow down aging and enhancing human activity；Glutathion is the special effects materials for releasing toxin, is A kind of small-molecular peptides being made up of three aminoacid, it as important in vivo antioxidant and free radical scavenger, such as with oneself Combined by base, heavy metal etc., so as to the poisonous substance being harmful in body is converted into harmless material, excreted external.
Further, the oil phase includes the component of following weight portion：2～10 parts of Cyclomethicone, neopentanoic acid 0.02～5 part of isodecyl ester, 0.03～7 part of hydrogenated jojoba oil, 0.07～1 part of tocopherol acetass；Tocopherol acetass are A kind of antioxidant, can effectively reduce the generation of wrinkle, reduce cell oxygen consumption, and antioxygen protection mechanism can protect body Murder by poisoning of the cell from free radical.The water is mutually including 0.08～0.5 part of the component Propylene Glycol, transparent of following weight percentage Matter 0.1～2 part of sodium of acid, 50～80 parts of water.Wherein：Hyaluronate sodium is mainly as the efficient water lock wetting agent of toiletrieses and flesh Skin repairs group, lifts the SPF of sunscreen product, gives product water and moistens soft skin sense, exquisite skin, permanent moisturizing, anti-anti-avulsion Water, histiocyte regeneration.
Further, the auxiliary agent includes the component of following weight portion：0.1～1 part of Methylisothiazolinone, essence 0.1 ～1 part；The pH adjusting agent is 0.1～1 part of triethanolamine., used as a kind of preservative, essence is used as one for Methylisothiazolinone Planting aromatic is used in cosmetics.
The preparation method of the cosmetics of above-mentioned desalination chloasma, it is characterised in that comprise the steps：
Step 1：Principal phase is warmed up to into 80～85 DEG C, 80 DEG C of 15～30min of insulation add water phase, stirring and dissolving completely, to take out Vacuum cool-down；
Step 2：Oil phase and pH adjusting agent, 1～3min of homogenizing are added when being down to 60～65 DEG C, is stirred；
Step 3：Being cooled to 45～50 DEG C adds auxiliary phase to stir；
Step 4：35～40 DEG C of addition auxiliary agents are cooled to, are stirred, obtained final product.
On the other hand, present invention also provides a kind of compositionss for treating chloasma, including above-mentioned cosmetics, also wrap Oral medicine and medicine for external use are included, the parts by weight of various raw materials are in the oral medicine：0.1～1 part of Margarita powder, Radix Glycyrrhizae 0.5～2 Part, 0.5～5 part of Fructus Corni, 0.5～5 part of Poria, 0.5～2 part of Radix Angelicae Sinensis, 0.5～5 part of the Radix Angelicae Dahuricae, 0.5～2 part of Flos Carthami, the Radix Paeoniae Alba 0.5 ～5 parts, 1～5 part of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：1～8 part of cracking-off agent, 1～5 part of titanium dioxide, 0.01～1 part of Gyno-Daktarin.
Further, the parts by weight of various raw materials are in the oral medicine：0.2～0.6 part of Margarita powder, Radix Glycyrrhizae 0.8～ 1.5 parts, 1～3 part of Fructus Corni, 1～3 part of Poria, 0.8～1.5 part of Radix Angelicae Sinensis, 1～3 part of the Radix Angelicae Dahuricae, 0.8～1.5 part of Flos Carthami, the Radix Paeoniae Alba 1 ～3 parts, 2～4 parts of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：2～5 parts of cracking-off agent, 2～4 parts of titanium dioxide, 0.01～0.03 part of Gyno-Daktarin.
Further, the parts by weight of various raw materials are in the oral medicine：0.3 part of Margarita powder, 1 part of Radix Glycyrrhizae, Fructus Corni 2 Part, 2 parts of Poria, 1 part of Radix Angelicae Sinensis, 2 parts of the Radix Angelicae Dahuricae, 1 part of Flos Carthami, 2 parts of the Radix Paeoniae Alba, 3 parts of Rhizoma Dioscoreae；The weight portion of each component in the medicine for external use Number is：3 parts of cracking-off agent, 2.5 parts of titanium dioxide, 0.01 part of Gyno-Daktarin.
The dosage form of the oral medicine is powder, pill, tablet, capsule etc., the shadow of the oral medicine of different dosage form to drug effect Ring difference not notable, powder is mainly adopted in the application.The medicine for external use is unguentum.
Further, the cracking-off agent is salicylic acid, glacial acetic acid or chloroacetic acid.Cracking-off agent is mainly used in removing in acidity In the chloasma of face deposition.The titanium dioxide is white powder, is applied to and have on the face whitening effect, and powder can To absorb the oils and fatss of face's powder, face's cleaning is kept.The Gyno-Daktarin be broad-spectrum antifungal medicine, with antiinflammatory, antiallergic, Antipruritic effect.
《Pharmacopoeia of People's Republic of China》And《Dictionary of medicinal plant》Indicate：Margarita has calm the nerves arresting convulsion, shade removing, solution The effects such as taking poison and growing muscle due, modern study also shows that Margarita powder is improving body immunity, slow down aging, freckle removing and whitening, supplement calcium Etc. aspect all there is unique effect.
Radix Glycyrrhizae, (scientific name：Glycyrrhiza uralensis Fisch) another name：State is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet Son.Pulse family, Glycyrrhiza perennial herb, root is sturdy with root stock, is a kind of tonification Chinese herbal medicine.To a kind of good medicine of human body, Medicinal part is root and rhizome, and Medicinal Materials Characters root is long 25～100 centimetres in cylinder, 0.6～3.5 centimetre of diameter.Feeble QI, taste It is sweet and special.Indication heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc..
Fructus Corni, another name Fructus Corni, Fructus Corni, mountain in meat, Fructus Corni etc., machaka or dungarunga, during mature fruit is Medicine, for vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission, enuresis frequent micturition, bleeding not during menses, profuse sweating collapse.
Poria, medicinal part is the dry sclerotia of funguses, with promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming.
Radix Angelicae Sinensis, call it is dry return, the Qin which, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, Radix Angelicae Sinensis, Radix Angelicae Sinensis body, contain that Radix Angelicae Sinensis, Radix Angelicae Sinensis are bent, Radix Angelicae Gigatiss, Perennial herb.Its root can be used as medicine, and be one of the most frequently used Chinese medicine.With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation, anticancer, Anti-ageing anti-old, immune the effect of.
The Radix Angelicae Dahuricae, is used as medicine with root, the function such as the dehumidifying that gets rid of illness, evacuation of pus granulation promoting, promoting blood circulation and stopping pain.Cure mainly anemofrigid cold, headache, nose Scorching, toothache.The diseases such as leucorrhea with red and white discharge, pain furuncle and phyma poison, can also make spice.
Flos Carthami, another name：Red blue flower, thorn safflower, Compositae, Flos Carthami platymiscium, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain contributes to controlling Jing Close, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, stasis of blood, chest side of body shouting pain, traumatic injury, sore swell and ache curative curative effect.There is blood circulation promoting and blood stasis dispelling, Effect of dissipate wet effect going to swell, it is to avoid anemia of pregnant woman uses, can otherwise cause miscarriage.
The Radix Paeoniae Alba, with smooth liver and relieve pain, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, extremity Spasm and pain, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Rhizoma Dioscoreae, another name：Rhizoma Dioscoreae, native potato, sweet potato Chinese yam, RHIIZOMA DIOSCOREAE fr0m Henan of China, Rhizomadioscoreae, white Rhizoma Dioscoreae, be《Chinese book on Chinese herbal medicine》The medical herbs for recording, Medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Rhizoma Dioscoreae has and nourishes strong, aid digestion, main the effect of hold back sweating due to debility, antidiarrheal Control insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes quench one's thirst, oliguria frequency, seminal emission, women's leukorrhagia and dyspeptic chronic enteritiss.
The invention has the advantages that：
In such scheme, there is provided a kind of compositionss of eliminating chloasma, comprising cosmetics for external use, medicine for external use and oral medicine, It is used to containing cracking-off agent, titanium dioxide and Gyno-Daktarin dispel the chloasma that formed of face in medicine for external use；Meanwhile, cooperation is taken By Margarita powder, Radix Glycyrrhizae, Fructus Corni, Poria, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Flos Carthami, the Radix Paeoniae Alba, 9 kinds of traditional Chinese medicines of Rhizoma Dioscoreae oral medicine, use In blood circulation promoting and blood stasis dispelling, immunity of organisms is improved, improve facial pigmentation, improved newly into metabolism；Coordinate cosmetics for external use be used for after Chloasma is desalinated in continuous whitening.Three uses cooperatively, evident in efficacy compared with traditional remedies, and has no toxic side effect, and can thoroughly dispel yellowish-brown Speckle, without bounce-back.
Specific embodiment
To make the technical problem to be solved in the present invention, technical scheme and advantage clearer, below in conjunction with being embodied as Example is described in detail.
The present invention is for the undesirable problem for being particularly easy to rebound of chloasma therapeutic effect in prior art, there is provided Yi Zhongyong In the compositionss for the treatment of chloasma.
Embodiment 1
The cosmetics of present invention desalination chloasma, including the component of following weight portion：3.15 parts of principal phase, 8.15 parts of auxiliary phase, 0.3 part of 70.6 parts of water phase, 6.3 parts of oil phase, 0.41 part of auxiliary agent and pH adjusting agent.Wherein：
The principal phase includes the component of following weight portion：
The auxiliary component by following parts by weight is constituted：
The water is made up of the component of following parts by weight：
0.1 part of Propylene Glycol
0.5 part of hyaluronate sodium
70 parts of water
The oil phase is made up of the component of following parts by weight：
The auxiliary agent is made up of the component of following parts by weight：
0.01 part of Methylisothiazolinone
0.4 part of essence
PH adjusting agent：0.3 part of triethanolamine
In addition, in the application eliminating chloasma compositionss, except comprising in addition to above-mentioned cosmetics for external use, also including oral medicine and Medicine for external use, the parts by weight of various raw materials are in the oral medicine：0.5 part of Margarita powder, 2 parts of Radix Glycyrrhizae, 5 parts of Fructus Corni, Poria 5 Part, 2 parts of Radix Angelicae Sinensis, 5 parts of the Radix Angelicae Dahuricae, 2 parts of Flos Carthami, 5 parts of the Radix Paeoniae Alba, 5 parts of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：Stripping 3 parts of de- agent, 2 parts of titanium dioxide, 0.05 part of Gyno-Daktarin.
Usage and dosage：
3 times a day for oral medicine, each 5g；
One time a day for medicine for external use, each 0.1g, continuous to disable using after 3 days；
Cosmetics for external use is daily 2～3 times, quantitative depending on face area, smears uniform.
Embodiment 2
The cosmetics of present invention desalination chloasma, including the component of following weight portion：4.25 parts of principal phase, 12.15 parts of auxiliary phase, 0.7 part of 2.08 parts of water phase, 11.1 parts of oil phase, 1.01 parts of auxiliary agent and pH adjusting agent.Wherein：
The principal phase includes the component of following weight portion：
The auxiliary component by following parts by weight is constituted：
The water is made up of the component of following parts by weight：
0.08 part of Propylene Glycol
2 parts of hyaluronate sodium
65 parts of water
The oil phase is made up of the component of following parts by weight：
The auxiliary agent is made up of the component of following parts by weight：
0.01 part of Methylisothiazolinone
1 part of essence
PH adjusting agent：0.7 part of triethanolamine
In addition, in the application eliminating chloasma compositionss, except comprising in addition to above-mentioned cosmetics for external use, also including oral medicine and Medicine for external use, the parts by weight of various raw materials are in the oral medicine：0.5 part of Margarita powder, 1.5 parts of Radix Glycyrrhizae, 2.5 parts of Fructus Corni, Fu 3 parts of Siberian cocklebur, 1 part of Radix Angelicae Sinensis, 2 parts of the Radix Angelicae Dahuricae, 1 part of Flos Carthami, 2 parts of the Radix Paeoniae Alba, 4 parts of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use： 5 parts of cracking-off agent, 1 part of titanium dioxide, 0.06 part of Gyno-Daktarin.
3 times a day for oral medicine, each 5g；
One time a day for medicine for external use, each 0.1g, continuous to disable using after 3 days；
Cosmetics for external use is daily 2～3 times, quantitative depending on face area, smears uniform.
Embodiment 3
The cosmetics of present invention desalination chloasma, including 5.14 parts of principal phase, 13.7 parts of auxiliary phase, 56.3 parts of water phase, oil phase 19 0.6 part of part, 0.51 part of auxiliary agent and pH adjusting agent.Wherein：
The principal phase includes the component of following weight portion：
The auxiliary component by following parts by weight is constituted：
The water is made up of the component of following parts by weight：
0.3 part of Propylene Glycol
1 part of hyaluronate sodium
55 parts of water
The oil phase is made up of the component of following parts by weight：
The auxiliary agent is made up of the component of following parts by weight：
0.01 part of Methylisothiazolinone
0.5 part of essence
PH adjusting agent：0.6 part of triethanolamine
In addition, in the application eliminating chloasma compositionss, except comprising in addition to above-mentioned cosmetics for external use, also including oral medicine and Medicine for external use, the parts by weight of various raw materials are in the oral medicine：0.2 part of Margarita powder, 1.5 parts of Radix Glycyrrhizae, 1 part of Fructus Corni, Poria 4 Part, 0.8 part of Radix Angelicae Sinensis, 1 part of the Radix Angelicae Dahuricae, 0.8 part of Flos Carthami, 2 parts of the Radix Paeoniae Alba, 4 parts of Rhizoma Dioscoreae；The parts by weight of each component in the medicine for external use For：5 parts of cracking-off agent, 2 parts of titanium dioxide, 0.03 part of Gyno-Daktarin.
3 times a day for oral medicine, each 5g；
One time a day for medicine for external use, each 0.1g, continuous to disable using after 3 days；
Cosmetics for external use is daily 2～3 times, quantitative depending on face area, smears uniform.
Embodiment 4
The cosmetics of present invention desalination chloasma, including 5.305 parts of principal phase, 15.3 parts of auxiliary phase, 65.5 parts of water phase, oil phase 15 1 part of part, 0.81 part of auxiliary agent and pH adjusting agent.Wherein：
The principal phase includes the component of following weight portion：
The auxiliary component by following parts by weight is constituted：
The water is made up of the component of following parts by weight：
0.5 part of Propylene Glycol
2 parts of hyaluronate sodium
63 parts of water
The oil phase is made up of the component of following parts by weight：
The auxiliary agent is made up of the component of following parts by weight：
0.01 part of Methylisothiazolinone
0.8 part of essence
PH adjusting agent：1 part of triethanolamine
In addition, in the application eliminating chloasma compositionss, except comprising in addition to above-mentioned cosmetics for external use, also including oral medicine and Medicine for external use, the parts by weight of various raw materials are in the oral medicine：0.6 part of Margarita powder, 1.5 parts of Radix Glycyrrhizae, 3 parts of Fructus Corni, Poria 3 Part, 1.5 parts of Radix Angelicae Sinensis, 3 parts of the Radix Angelicae Dahuricae, 1.5 parts of Flos Carthami, 3 parts of the Radix Paeoniae Alba, 4 parts of Rhizoma Dioscoreae；The parts by weight of each component in the medicine for external use For：2 parts of cracking-off agent, 4 parts of titanium dioxide, 0.02 part of Gyno-Daktarin.
3 times a day for oral medicine, each 5g；
One time a day for medicine for external use, each 0.1g, continuous to disable using after 3 days；
Cosmetics for external use is daily 2～3 times, quantitative depending on face area, smears uniform.
Embodiment 5
The cosmetics of present invention desalination chloasma, including 6.03 parts of principal phase, 13.75 parts of auxiliary phase, 76.85 parts of water phase, oil phase 1 part of 14 parts, 0.31 part of auxiliary agent and pH adjusting agent.Wherein：
The principal phase includes the component of following weight portion：
The auxiliary component by following parts by weight is constituted：
The water is made up of the component of following parts by weight：
0.35 part of Propylene Glycol
1.5 parts of hyaluronate sodium
75 parts of water
The oil phase is made up of the component of following parts by weight：
The auxiliary agent is made up of the component of following parts by weight：
0.01 part of Methylisothiazolinone
0.3 part of essence
PH adjusting agent：1 part of triethanolamine
In addition, in the application eliminating chloasma compositionss, except comprising in addition to above-mentioned cosmetics for external use, also including oral medicine and Medicine for external use, the parts by weight of the various raw materials of the oral medicine are：0.3 part of Margarita powder, 1 part of Radix Glycyrrhizae, 2 parts of Fructus Corni, 2 parts of Poria, 1 part of Radix Angelicae Sinensis, 2 parts of the Radix Angelicae Dahuricae, 1 part of Flos Carthami, 2 parts of the Radix Paeoniae Alba, 3 parts of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：Cracking-off agent 3 parts, 2.5 parts of titanium dioxide, 0.01 part of Gyno-Daktarin.
3 times a day for oral medicine, each 5g；
One time a day for medicine for external use, each 0.1g, continuous to disable using after 3 days；
Cosmetics for external use is daily 2～3 times, quantitative depending on face area, smears uniform.
The compositionss of the eliminating chloasma that the present invention is provided, comprising cosmetics for external use, medicine for external use and oral medicine, in medicine for external use It is used to dispel the chloasma that face has been formed containing cracking-off agent, titanium dioxide and Gyno-Daktarin；Meanwhile, cooperation is taken by Margarita Powder, Radix Glycyrrhizae, Fructus Corni, Poria, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae, Flos Carthami, the Radix Paeoniae Alba, the oral medicine of 9 kinds of traditional Chinese medicines of Rhizoma Dioscoreae, for QI invigorating Blood, blood circulation promoting and blood stasis dispelling improves immunity of organisms, improves facial pigmentation；Cosmetics for external use is used for whitening and desalinates chloasma.
The present invention also provides a kind of preparation method of above-mentioned cosmetics for external use, comprises the steps：
Step 1：Principal phase is warmed up to into 85 DEG C, 20min is incubated, water phase is added, stirring and dissolving completely, lower the temperature by evacuation；
Step 2：Oil phase and pH adjusting agent, 1～3min of homogenizing are added when being down to 65 DEG C, is stirred；
Step 3：Being cooled to 45 DEG C adds auxiliary phase to stir；
Step 4：40 DEG C of addition auxiliary agents are cooled to, are stirred, obtain final product paste cosmetics for external use.
It is of the present invention to be expanded on further in the major clinical trial of chloasma using the compositionss in embodiment 3 below The beneficial effect of compositionss：
Patient is all from the volunteer of Ningxia various places.April totally 829 2016 July in 2008.Clinical criteria reference Revised chloasma clinical diagnosises in 2003 and criterion of therapeutical effect.
Being selected into 90 carries out this test curative effect demonstration, meets 18 years old to 58 years old patient of above diagnostic criteria.Have meet with Under the needs of wherein reject 1. skin lesion and the clear and definite relative of menstrual cycle；2. anemia of pregnant woman and the diseases such as liver, cardiovascular are associated with Patient；3. contraception is taken in not enough half a year or half a year after giving a birth；4. in nearly 3 months once the medicine of system application for the treatment of chloasma or Additive method therapist；5. stopped treatment or replacing medicine and method person during treating；6. data not umbra ring Outcome measure or Drop by the wayside observer.
3 groups are randomly divided into according to medical order：
(1) criterion group：Using external-applied ointment of the present invention, oral medicine of the present invention and cosmetics for external use criterion group 30 are taken orally. Man 2, female 28.Year mean age (42 ± 30), the course of disease (9 ± 1.3) year.The ointment of the external present invention coordinates Chinese medicine for oral administration system Cosmetics of the external present invention again after agent 7 days.
(2) matched group 1：Using traditional cosmetics speckle dispelling formula group 30, man 9, female 21, mean age (38.5 ± 29) year, the course of disease (5 ± 3.5) year.The Hydrochinone Cream of external 4%, 1% all-trans retinoic acid frost (Di Wei, the pharmacy life of Chongqing nation of China Produce), 1% hydrocortisone butyrate ointment (production of hydrocortisone butyrate Tianjin Pharmaceutical Group Corp., Ltd).
(3) matched group 2：Laser therapy group 30, man 1, female 29.Year mean age (38.3 ± 26), the course of disease (2.8 ± 1.1) year.The laser of external 532, E light treatments, are applied outward after 7 days with the EGF reparative factors circulated on market.
Various groups of medicines and Therapeutic Method etc. are used on request than mixing when treating respectively.It was a course for the treatment of per 4 weeks, respectively at 4th week, the 8th week, the 12nd week observation curative effect.Each group M-F, mean age, Clinical typing, the course of disease, the scoring of the skin being grievously injured degree The aspects such as data are statistically analyzed no significant difference (P>0.05).Three groups of patients treat during all should lucifuge, do not use it His cosmetics.
Curative effect determinate standard：
It is basic to cure：1. mottle area disappear >=90%, color disappears substantially；2. point system is calculated and declines index >=0.8. It is effective：1. mottle area disappear 60%～89%, color is substantially thin out；2. point system is calculated and declines index >=0.5.Take a turn for the better：① Naked eyes regard mottle area regression 30%～59%, and color is thin out；2. point system is calculated and declines index >=0.3.It is invalid：1. visually regard Mottle area disappears<30%, color change is not obvious；2. point system is calculated and declines index≤0.Wherein, effective percentage controlling substantially Further effective meter.
The clinical score and standard of skin lesion area and color：
1. damage area to score 0 point, without skin lesion；2. 1 point, skin lesion area<2cm2；2 points, skin lesion 2～4cm of area2；3. 3 points are Skin lesion area>4cm2。
Skin lesion color score：0 is normal skin tone；1 is filbert；2 is brown；3 is dark brown.
Total mark=area scoring+color score.
Decline the front total mark of total mark/treatment after the front total mark-treatment of index=treatment.
Observation result：The curative effect of criterion group and matched group is shown in Table 1
The curative effect of the criterion group of table 1 and matched group
Group Number of cases It is basic to cure It is effective Take a turn for the better It is invalid Effective percentage %
Criterion group (4 weeks) 30 1 15 9 4 53.33%
Matched group 1 (4 weeks) 30 0 12 4 14 40%
Matched group 2 (4 weeks) 30 0 3 10 17 10%
Criterion group (8 weeks) 30 13 12 5 0 83.33%
Matched group 1 (8 weeks) 30 3 12 8 6 50.33%
Matched group 2 (8 weeks) 30 0 15 8 7 50%
Criterion group (12 weeks) 30 22 7 1 0 96.67%
Matched group 1 (12 weeks) 30 6 12 8 4 60%
Matched group 2 (12 weeks) 30 5 14 7 4 63.33%
Have 10 untoward reaction for erythema, causalgia, desquamation and prurituss occur in this test group, but can stand and not shadow Ring continuation medication to disappear after 2 weeks, in present composition criterion group on probation, only 1 erythema occurs, and prurituss obtain bad anti- Should, but can tolerate, SM symptom disappearance after 2 weeks.
As shown in Table 1, compared with Traditional makeup and the matched group using laser treatment, the compositionss in the application are to Huang The effective percentage of brown patch up to 96.67%, the significantly larger than effective percentage of matched group.And it is longer using the time of this compositions, dispel Huang The effect of brown patch is better.The patients with mild course for the treatment of of 4 weeks can cure, in, severe patient persistently can fully recover from an illness using 6-8 month More, cure rate is up to 99%, and without bounce-back.
The above is the preferred embodiment of the present invention, it is noted that for those skilled in the art For, on the premise of without departing from principle of the present invention, some improvements and modifications can also be made, these improvements and modifications Should be regarded as protection scope of the present invention.

Claims (10)

1. a kind of cosmetics for desalinating chloasma, it is characterised in that including the component of following weight portion：Principal phase 2.253～ 7.35 parts, 2.39～18.3 parts of auxiliary phase, 55.18～82.5 parts of water phase, 2.12～23 parts of oil phase, 0.2～2 part of auxiliary agent and pH regulator 0.1～1 part of agent.
2. it is used to according to claim 1 desalinate the cosmetics of chloasma, it is characterised in that the principal phase includes following weight The component of part：0.8～3 part of Chondrus crispus extract, 0.04～2 part of glycine betaine, 0.003～0.9 part of butanediol, acryloyl two N-methyltaurine ammonium/0.08～0.3 part of VP copolymers, 0.01～0.15 part of methyl hydroxybenzoate, 0.6～1 part of carbomer.
3. it is used to desalinate the cosmetics of chloasma according to power requires 2, it is characterised in that the auxiliary phase includes following weight portion Component：0.01～2 part of Glycyrrhiza glabra L. root extract, 0.2～3 part of ascorbic acid sodium phosphate, 0.03～2 part of ubiquinone, paddy Guang 2～11 parts of sweet peptide, 0.15～0.3 part of HSPC.
4. it is used to according to claim 3 desalinate the cosmetics of chloasma, it is characterised in that the oil phase includes following weight The component of part：2～10 parts of Cyclomethicone, 0.02～5 part of neopentanoic acid isodecyl ester, hydrogenated jojoba oil 0.03～7 Part, 0.07～1 part of tocopherol acetass；The water is mutually including the component of following weight percentage：Propylene Glycol 0.08～0.5 Part, 0.1～2 part of hyaluronate sodium, 50～80 parts of water.
5. it is used to according to claim 4 desalinate the cosmetics of chloasma, it is characterised in that the auxiliary agent includes following weight The component of part：0.1～1 part of Methylisothiazolinone, 0.1～1 part of essence；The pH adjusting agent is 0.1～1 part of triethanolamine.
6. the preparation method of the cosmetics of the arbitrary described desalination chloasma of claim 1-5, it is characterised in that including walking as follows Suddenly：
Step 1：Principal phase is warmed up to into 80～85 DEG C, 80 DEG C of 15～30min of insulation add water phase, and stirring and dissolving is complete, evacuation Cooling；
Step 2：Oil phase and pH adjusting agent, 1～3min of homogenizing are added when being down to 60～65 DEG C, is stirred；
Step 3：Being cooled to 45～50 DEG C adds auxiliary phase to stir；
Step 4：35～40 DEG C of addition auxiliary agents are cooled to, are stirred, obtained final product.
7. a kind of arbitrary described cosmetics of compositionss for treating chloasma, including claim 1-6, it is characterised in that Also include oral medicine and medicine for external use, the parts by weight of various raw materials are in the oral medicine：0.1～1 part of Margarita powder, Radix Glycyrrhizae 0.5 ～2 parts, 0.5～5 part of Fructus Corni, 0.5～5 part of Poria, 0.5～2 part of Radix Angelicae Sinensis, 0.5～5 part of the Radix Angelicae Dahuricae, 0.5～2 part of Flos Carthami, the Radix Paeoniae Alba 0.5～5 part, 1～5 part of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：1～8 part of cracking-off agent, titanium dioxide 1～5 Part, 0.01～1 part of Gyno-Daktarin.
8. it is used to according to claim 7 treat the compositionss of chloasma, it is characterised in that various raw materials in the oral medicine Parts by weight be：0.2～0.6 part of Margarita powder, 0.8～1.5 part of Radix Glycyrrhizae, 1～3 part of Fructus Corni, 1～3 part of Poria, Radix Angelicae Sinensis 0.8 ～1.5 parts, 1～3 part of the Radix Angelicae Dahuricae, 0.8～1.5 part of Flos Carthami, 1～3 part of the Radix Paeoniae Alba, 2～4 parts of Rhizoma Dioscoreae；Each component in the medicine for external use Parts by weight are：2～5 parts of cracking-off agent, 2～4 parts of titanium dioxide, 0.01～0.03 part of Gyno-Daktarin.
9. it is used to according to claim 8 treat the compositionss of chloasma, it is characterised in that various raw materials in the oral medicine Parts by weight be：It is 0.3 part of Margarita powder, 1 part of Radix Glycyrrhizae, 2 parts of Fructus Corni, 2 parts of Poria, 1 part of Radix Angelicae Sinensis, 2 parts of the Radix Angelicae Dahuricae, 1 part of Flos Carthami, white 2 parts of Chinese herbaceous peony, 3 parts of Rhizoma Dioscoreae；The parts by weight of each component are in the medicine for external use：3 parts of cracking-off agent, 2.5 parts of titanium dioxide, Gyno-Daktarin 0.01 part.
10. it is used to treat the compositionss of chloasma according to claim 8 or 9 is arbitrary, it is characterised in that the cracking-off agent is Salicylic acid, glacial acetic acid or chloroacetic acid.
CN201610974888.8A 2016-11-07 2016-11-07 Composition for treating chloasma Pending CN106619238A (en)

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CN114146128A (en) * 2021-11-11 2022-03-08 徐雪灵 Composition for treating chloasma and preparation method thereof

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