CN102335344A - Chinese medicinal composition for treating chloasma - Google Patents

Chinese medicinal composition for treating chloasma Download PDF

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Publication number
CN102335344A
CN102335344A CN2011103218033A CN201110321803A CN102335344A CN 102335344 A CN102335344 A CN 102335344A CN 2011103218033 A CN2011103218033 A CN 2011103218033A CN 201110321803 A CN201110321803 A CN 201110321803A CN 102335344 A CN102335344 A CN 102335344A
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parts
flos
radix
medicine
external use
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CN102335344B (en
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龚杨宇
黄细刚
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Abstract

The invention discloses a Chinese medicinal composition for treating chloasma. The Chinese medicinal composition comprises an oral medicine and an externally applied medicine. The oral medicine consists of the following powdery Chinese herbal medicines in part by weight: 6.5 to 9.5 parts of Angelica sinensis, 6 to 9.5 parts of root of red-rooted salvia, 6.5 to 9.5 parts of bupleurum chinense, 6.5 to 15 parts of tuckahoe, 6 to 9 parts of sinkiang arnebia root, 6.5 to 15 parts of alisma plantagoaquatica, 6.5 to 9.5 parts of wax gourd seed, 6.5 to 9.5 parts of angelica dahurica, 6.5 to 9.5 parts of Chinese trumpet creeper, 6.5 to 9.5 parts of rose, 6.5 to 9.5 parts of hibiscus, 6.5 to 9.5 parts of lotus, 6.5 to 9.5 parts of peach blossom, 6.5 to 9.5 parts of bletilla striata, 6.5 to 15 parts of Chinese yam, 3.5 to 6.5 parts of safflower, and 3.5 to 6.5 parts of liquorice; and the externally applied medicine consists of the lowing Chinese herbal medicines in part by weight: 20 to 40 parts of bletilla striata, 20 to 40 parts of angelica dahurica, 10 to 20 parts of safflower, and 15 to 30 parts of root of red-rooted salvia. The invention has the advantages that: chloasma is treated by combining the oral medicine and the externally applied medicine, and the Chinese medicinal composition has a better treatment effect than a single medicine.

Description

A kind of Chinese medicine composition of treating chloasma
Technical field
The invention belongs to Chinese medicine composition, relate in particular to a kind of Chinese medicine composition of treating chloasma.
Background technology
Chloasma disease belongs to a kind of common multiple disease, betides the facial pigmentation disease, influences very much attractive in appearancely, and the women is many especially, and China has and surpasses 70% crowd and suffer from.Morbidity and internal injury caused by excess of seven emotions, irritability stasis, improper diet and overtiredness, deficiency of both the liver and kidney, married woman's irregular menstruations etc. are relevant.At present, be used to treat the oral medicine, medicine for external use of chloasma, all be main that all less than satisfied curative effect, what have produces effect during medication with Metabolism, Vitamins and Hormones, the back easy relapse of discontinuing medication, the curative effect that has is not remarkable or the like.
Summary of the invention
The objective of the invention is to overcome the problem of above existence, a kind of Chinese medicine composition of the treatment chloasma of treating is provided.
The Chinese medicine composition of treatment chloasma provided by the invention comprises oral medicine and medicine for external use,
Said oral medicine is made up of the powder raw material medicament of following weight portion content:
6.5~9.5 parts of Radix Angelicae Sinensis, 6~9.5 parts of Radix Salviae Miltiorrhizaes, 6.5~9.5 parts of Radix Bupleuri, 6.5~15 parts in Poria, 6~9 parts of Radix Arnebiae (Radix Lithospermi)s, 6.5~15 parts of Rhizoma Alismatis, 6.5~9.5 parts of Semen Benincasaes, 6.5~9.5 parts of the Radixs Angelicae Dahuricae, 6.5~9.5 parts of Flos Campsiss, 6.5~9.5 parts of Flos Rosae Rugosaes, 6.5~9.5 parts of Flos Hibisci Mutabilis, 6.5~9.5 parts of Flos Nelumbinises, 6.5~9.5 parts in Flos persicae, 6.5~9.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6.5~15 parts of Rhizomadioscoreae, 3.5~6.5 parts on Flos Carthami, 3.5~6.5 parts in Radix Glycyrrhizae;
Said medicine for external use is made up of the crude drug of following weight portion content:
20~40 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20~40 parts of the Radixs Angelicae Dahuricae, 10~20 parts on Flos Carthami, 15~30 parts of Radix Salviae Miltiorrhizaes.
The preferred content of said oral medicine is:
8 parts of Radix Angelicae Sinensis, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Bupleuri, 10.5 parts in Poria, 9 parts of Radix Arnebiae (Radix Lithospermi)s, 10.5 parts of Rhizoma Alismatis, 8 parts of Semen Benincasaes, 8 parts of the Radixs Angelicae Dahuricae, 8 parts of Flos Campsiss, 8 parts of Flos Rosae Rugosaes, 8 parts of Flos Hibisci Mutabilis; 8 parts of Flos Nelumbinises, 8 parts in Flos persicae, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10.5 parts of Rhizomadioscoreae, 5 parts on Flos Carthami, 5 parts in Radix Glycyrrhizae.
The preferred content of said medicine for external use is:
30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of the Radixs Angelicae Dahuricae, 15 parts on Flos Carthami, 23 parts of Radix Salviae Miltiorrhizaes.
Said medicine for external use is a powder, is mainly used in facial film, can prepare by conventional method.
Said medicine for external use also can be unguentum; Its preparation method is: get the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Flos Carthami, the Radix Salviae Miltiorrhizae of said crude drug, dry, chopping; By proportioning mixing and water adding 15-25 part; Dense frying in shallow oil endured 1.5-2.5 hours for a long time, got the supernatant medicinal liquid after the cooling, and the percentage by weight of pressing the supernatant medicinal liquid adds Tryfac 5573 potassium (HR-S1) 2.5%, glycerol 6%, ethyl ester 0.1 % in the supernatant medicinal liquid; Be heated to 75-85 degrees centigrade for use; In addition get glyceryl monostearate 2%, 18 hexadecanol 4%, liquid paraffin 7%, isopropyl palmitate (IPP) 2%, isopropyl myristate (IPM) 4%, being heated to the boiling back and adding supernatant medicinal liquid for use and be stirred to emulsifying and condense, promptly get unguentum medicine for external use of the present invention by the percentage by weight of supernatant medicinal liquid.
In the Chinese medicine of the present invention the function of each composition with cure mainly:
Its Main Ingredients and Appearance ferulic acid of Radix Angelicae Sinensis, but restraint of tyrosinase is active, prevents that the tryrosinase oxidation from forming pigment.
Radix Salviae Miltiorrhizae, Flos Carthami can be adjusted endocrine function, promote skin metabolism, promoting blood flow to regulate menstruation.
Poria, Rhizoma Alismatis, Rhizomadioscoreae tonifying speen and tonifying kidney rush down wet.
Radix Bupleuri is soothing the liver to expel the heat-evil.
Radix Arnebiae (Radix Lithospermi) suppresses lutropin.
The Pseudobulbus Bletillae (Rhizoma Bletillae) contains Pseudobulbus Bletillae (Rhizoma Bletillae) ethanol has inhibitory action to tyrosinase activity and melanin generation.
Hot the loosing of the Radix Angelicae Dahuricae dispeled the wind, and reaches women's head-ornaments on the fragrance, and the dispel foul smell of kidney of Semen Benincasae is joined by the priming sick institute that goes directly.
All flower regulating menstruation speckle removing.
The pharmacodynamics principle:
The chloasma cause of disease is complicated, and paathogenic factor still end is clear and definite fully, and doctor trained in Western medicine is thought and the endocrine disturbance at present, heredity, cosmetics, and the melanocyte Metabolic disorder, multiple factor such as psychentonia is relevant.Primary disease is also obstinate, does not still have the specific treatment method at present.It is dirty in close relations that the traditional Chinese medical science thinks that primary disease betides liver,spleen,kidney three.Pathogenesis belongs to simulataneous insufficiency and excessive, and real person is many by stagnation of QI due to depression of the liver, strongly fragrant and heat-transformation, the cloudy blood of burning, blood stasis venation; Void person is many by deficiency of the liver and kindey, Chong and Ren channel disorder, and insufficiency of water leading to hyperactivity of fire, the cloudy blood of burning more, venation block, therefore " deficiency of the liver and kindey, obstruction of collaterals by blood stasis " is that pathogenesis is crucial, the suitable liver nourishing lung heat clearing of treatment, the speckle removing of invigorating blood circulation is a rule of treatment.Cooperate medicine for external use simultaneously, promote its local blood circulation, to reach the function of venation block mediation, the speckle removing of invigorating blood circulation.
For oral administration have nourishing the liver and kidney, expelling wind and clearing away heat, promoting the flow of QI in the collateral by warming the meridian, dispersing the stagnated live-QI to relieve the stagnation of QI, the merit of invigorating the spleen for eliminating dampness with medicine for external use.All medicines share has the logical soft and moist skin of hundred arteries and veins of a surname, to reach invigorating kidney, promoting blood circulation, the effect of soothing liver-QI speckle removing.Modern medicine study confirms: tryrosinase is the main rate-limiting enzyme of melanocyte biosynthesis pathway, has stronger restraint of tyrosinase active function and take orally with external-applied medicinal powder, prevents that the tyrosine oxidation from forming melanocyte.Simultaneously effectively restraint of tyrosinase is active and absorb ultraviolet again, the common performance effect that speckle removing is improved looks of invigorating blood circulation.
In sum, the Chinese medicine composition advantage that the present invention filters out is: adopt oral medicine and the medicine for external use treatment chloasma that combines, but promoting QI circulation for relieving depression, promoting blood flow to regulate menstruation; Flat invigorating the liver and kidney, spleen invigorating expels the heat-evil, blood cooling and ecchymoses removing, up women's head-ornaments; Reach skin outward, have endocrine regulation, promote skin metabolism, suppress the effect of cutaneous pigmentation; And the reparation epidermis is arranged, the effect of the pore that compacts has better therapeutic effect than single medicine.
Below in conjunction with embodiment the present invention is done further explanation.
The specific embodiment
The Chinese medicine composition that the present invention treats chloasma comprises oral medicine and medicine for external use, adopts following component and bulk drugs:
Embodiment 1
Oral medicine:
6.5 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6.5 parts of Radix Bupleuri, 6.5 parts in Poria, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6.5 parts of Rhizoma Alismatis, 6.5 parts of Semen Benincasaes, 6.5 parts of the Radixs Angelicae Dahuricae, 6.5 parts of Flos Campsiss, 6.5 parts of Flos Rosae Rugosaes, 6.5 parts of Flos Hibisci Mutabilis, 6.5 parts of Flos Nelumbinises, 6.5 parts in Flos persicae, 6.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6.5 parts of Rhizomadioscoreae, 3.5 parts on Flos Carthami, 3.5 parts in Radix Glycyrrhizae;
Medicine for external use:
20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of the Radixs Angelicae Dahuricae, 10 parts on Flos Carthami, 15 parts of Radix Salviae Miltiorrhizaes.
Embodiment 2
Oral medicine:
9.5 parts of Radix Angelicae Sinensis, 9.5 parts of Radix Salviae Miltiorrhizaes, 9.5 parts of Radix Bupleuri, 15 parts in Poria, 9 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Alismatis, 9.5 parts of Semen Benincasaes, 9.5 parts of the Radixs Angelicae Dahuricae, 9.5 parts of Flos Campsiss, 9.5 parts of Flos Rosae Rugosaes, 9.5 parts of Flos Hibisci Mutabilis, 9.5 parts of Flos Nelumbinises, 9.5 parts in Flos persicae, 9.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Rhizomadioscoreae, 6.5 parts on Flos Carthami, 6.5 parts in Radix Glycyrrhizae;
Medicine for external use:
40 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 40 parts of the Radixs Angelicae Dahuricae, 20 parts on Flos Carthami, 30 parts of Radix Salviae Miltiorrhizaes.
Embodiment 3
Oral medicine:
8 parts of Radix Angelicae Sinensis, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Bupleuri, 10.5 parts in Poria, 9 parts of Radix Arnebiae (Radix Lithospermi)s, 10.5 parts of Rhizoma Alismatis, 8 parts of Semen Benincasaes, 8 parts of the Radixs Angelicae Dahuricae, 8 parts of Flos Campsiss, 8 parts of Flos Rosae Rugosaes, 8 parts of Flos Hibisci Mutabilis; 8 parts of Flos Nelumbinises, 8 parts in Flos persicae, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10.5 parts of Rhizomadioscoreae, 5 parts on Flos Carthami, 5 parts in Radix Glycyrrhizae;
Medicine for external use:
30 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of the Radixs Angelicae Dahuricae, 15 parts on Flos Carthami, 23 parts of Radix Salviae Miltiorrhizaes.
Embodiment 4
Oral medicine:
6.5 parts of Radix Angelicae Sinensis, 6 parts of Radix Salviae Miltiorrhizaes, 6.5 parts of Radix Bupleuri, 6.5 parts in Poria, 6 parts of Radix Arnebiae (Radix Lithospermi)s, 6.5 parts of Rhizoma Alismatis, 6.5 parts of Semen Benincasaes, 6.5 parts of the Radixs Angelicae Dahuricae, 9.5 parts of Flos Campsiss, 9.5 parts of Flos Rosae Rugosaes, 9.5 parts of Flos Hibisci Mutabilis, 9.5 parts of Flos Nelumbinises, 9.5 parts in Flos persicae, 9.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 15 parts of Rhizomadioscoreae, 6.5 parts on Flos Carthami, 6.5 parts in Radix Glycyrrhizae;
Medicine for external use:
20 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20 parts of the Radixs Angelicae Dahuricae, 20 parts on Flos Carthami, 30 parts of Radix Salviae Miltiorrhizaes.
Embodiment 5
Oral medicine:
9.5 parts of Radix Angelicae Sinensis, 9.5 parts of Radix Salviae Miltiorrhizaes, 9.5 parts of Radix Bupleuri, 15 parts in Poria, 9 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Rhizoma Alismatis, 9.5 parts of Semen Benincasaes, 9.5 parts of the Radixs Angelicae Dahuricae, 6.5 parts of Flos Campsiss, 6.5 parts of Flos Rosae Rugosaes, 6.5 parts of Flos Hibisci Mutabilis, 6.5 parts of Flos Nelumbinises, 6.5 parts in Flos persicae, 6.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6.5 parts of Rhizomadioscoreae, 3.5 parts on Flos Carthami, 3.5 parts in Radix Glycyrrhizae;
Medicine for external use:
40 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 40 parts of the Radixs Angelicae Dahuricae, 10 parts on Flos Carthami, 15 parts of Radix Salviae Miltiorrhizaes.
Oral medicine and medicine for external use among above-mentioned each embodiment all adopt powder.
The method for preparing of powder crude drug adopts conventional method: with said crude drug clean, dry, be crushed to smalls, sieve through 120 eye mesh screens, being packed in bag after oral medicine and medicine for external use mix, sterilize by said proportioning respectively gets final product.
The powder medicine for external use is used for facial film, transfers deposited affected part with Ovum Gallus domesticus album during use, and two once.
Oral medicine 139 gram/bags, each bag brews, takes with boiled water, early, middle and late three times of every day.
Medicine for external use among above-mentioned each embodiment also can adopt unguentum; Its preparation method is: get the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Flos Carthami, the Radix Salviae Miltiorrhizae of said crude drug, dry, chopping; By proportioning mixing and water adding 15-25 part; Dense frying in shallow oil endured 1.5-2.5 hours for a long time, got the supernatant medicinal liquid after the cooling, and the percentage by weight of pressing the supernatant medicinal liquid adds Tryfac 5573 potassium (HR-S1) 2.5%, glycerol 6%, ethyl ester 0.1 % in the supernatant medicinal liquid; Be heated to 75-85 degrees centigrade for use; In addition get glyceryl monostearate 2%, 18 hexadecanol 4%, liquid paraffin 7%, isopropyl palmitate (IPP) 2%, isopropyl myristate (IPM) 4%, being heated to the boiling back and adding supernatant medicinal liquid for use and be stirred to emulsifying and condense, promptly get unguentum medicine for external use of the present invention by the percentage by weight of supernatant medicinal liquid.
The unguentum medicine for external use can be used as protective skin cream and uses, once a day.
Curative effect judging standard:
After medication January, pigment begins thin out for effectively.After medication half a year to one year, pigmented spots disappear, and not recurring is to cure.
Clinical data:
Women's 100 examples, the age 20 is to 50 years old, and medical history 1 year is with interior 10 examples, 50 examples in 1-3 years, person's 40 examples more than 3 years.
Therapeutic Method:
Oral medicine brews with boiled water, takes early, middle and late three times of every day.The powder medicine for external use is modulated facial film with Ovum Gallus domesticus album, applies the affected part, and each 35-45 minutes, two once.The unguentum medicine for external use is smeared the affected part in right amount, once a day, can work as protective skin cream.1 month is a course of treatment.
Therapeutic effect:
1. medication is after one month, and 100 examples all have pigment desalination in various degree, effective percentage 96%.
2. medication is after 3 months, and 60 routine skin lesion disappear.
3. after medication half a year, the only surplus a small amount of skin lesion of 10 examples, 90 examples all do not have recurrence, cure rate 90%.

Claims (5)

1. A kind of Chinese medicine composition of treating chloasma is characterized in that comprising oral medicine and medicine for external use,
Said oral medicine is made up of the powder raw material medicament of following weight portion content:
6.5~9.5 parts of Radix Angelicae Sinensis, 6~9.5 parts of Radix Salviae Miltiorrhizaes, 6.5~9.5 parts of Radix Bupleuri, 6.5~15 parts in Poria, 6~9 parts of Radix Arnebiae (Radix Lithospermi)s, 6.5~15 parts of Rhizoma Alismatis, 6.5~9.5 parts of Semen Benincasaes, 6.5~9.5 parts of the Radixs Angelicae Dahuricae, 6.5~9.5 parts of Flos Campsiss, 6.5~9.5 parts of Flos Rosae Rugosaes, 6.5~9.5 parts of Flos Hibisci Mutabilis, 6.5~9.5 parts of Flos Nelumbinises, 6.5~9.5 parts in Flos persicae, 6.5~9.5 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 6.5~15 parts of Rhizomadioscoreae, 3.5~6.5 parts on Flos Carthami, 3.5~6.5 parts in Radix Glycyrrhizae;
Said medicine for external use is made up of the crude drug of following weight portion content:
20~40 parts of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 20~40 parts of the Radixs Angelicae Dahuricae, 10~20 parts on Flos Carthami, 15~30 parts of Radix Salviae Miltiorrhizaes.
2. The Chinese medicine composition of treatment chloasma according to claim 1 is characterized in that the content of said oral medicine is:
8 parts of Radix Angelicae Sinensis, 8 parts of Radix Salviae Miltiorrhizaes, 8 parts of Radix Bupleuri, 10.5 parts in Poria, 9 parts of Radix Arnebiae (Radix Lithospermi)s, 10.5 parts of Rhizoma Alismatis, 8 parts of Semen Benincasaes, 8 parts of the Radixs Angelicae Dahuricae, 8 parts of Flos Campsiss, 8 parts of Flos Rosae Rugosaes, 8 parts of Flos Hibisci Mutabilis; 8 parts of Flos Nelumbinises, 8 parts in Flos persicae, 8 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 10.5 parts of Rhizomadioscoreae, 5 parts on Flos Carthami, 5 parts in Radix Glycyrrhizae.
3. The Chinese medicine composition of treatment chloasma according to claim 2 is characterized in that the content of said medicine for external use is:
30 parts of Pseudobulbus Bletillae (Rhizoma Bletillae)s, 30 parts of the Radixs Angelicae Dahuricae, 15 parts on Flos Carthami, 23 parts of Radix Salviae Miltiorrhizaes.
4. is characterized in that according to the Chinese medicine composition of claim 1 or 3 described treatment chloasma said medicine for external use is a powder, is mainly used in facial film.
5. are according to the Chinese medicine composition of claim 1 or 3 described treatment chloasma; It is characterized in that said medicine for external use is a unguentum; Its preparation method is: get the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Angelicae Dahuricae, Flos Carthami, the Radix Salviae Miltiorrhizae of said crude drug, dry, chopping; By proportioning mixing and water adding 15-25 part; Dense frying in shallow oil endured 1.5-2.5 hours for a long time, got the supernatant medicinal liquid after the cooling, and the percentage by weight of pressing the supernatant medicinal liquid adds Tryfac 5573 potassium (HR-S1) 2.5%, glycerol 6%, ethyl ester 0.1 % in the supernatant medicinal liquid; Be heated to 75-85 degrees centigrade for use; In addition get glyceryl monostearate 2%, 18 hexadecanol 4%, liquid paraffin 7%, isopropyl palmitate (IPP) 2%, isopropyl myristate (IPM) 4%, being heated to the boiling back and adding supernatant medicinal liquid for use and be stirred to emulsifying and condense, promptly get unguentum medicine for external use of the present invention by the percentage by weight of supernatant medicinal liquid.
CN 201110321803 2011-10-21 2011-10-21 Chinese medicinal composition for treating chloasma Expired - Fee Related CN102335344B (en)

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CN102335344B CN102335344B (en) 2013-01-23

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103285276A (en) * 2013-06-18 2013-09-11 冯宇伟 Medicament for beautifying and preparation method thereof
CN103751635A (en) * 2013-12-31 2014-04-30 青岛恒波仪器有限公司 Traditional Chinese medicine mask for treating chloasma and preparation method thereof
CN103751709A (en) * 2013-12-31 2014-04-30 青岛恒波仪器有限公司 Traditional Chinese medicinal composition for treating chloasma and preparation method thereof
CN104306661A (en) * 2014-10-31 2015-01-28 夏征梅 Traditional Chinese medicine for curing chloasma
CN106619238A (en) * 2016-11-07 2017-05-10 徐雪灵 Composition for treating chloasma
CN108324636A (en) * 2018-03-23 2018-07-27 北京明弘科贸有限责任公司 A kind of skin care compositions and with careful pore effect cosmetic, preparation method

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
唐黎标: "自古鲜花多妙用", 《广西林业》 *
石本玉: "内服祛斑美容散治疗黄褐斑", 《临床皮肤科杂志》 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103285276A (en) * 2013-06-18 2013-09-11 冯宇伟 Medicament for beautifying and preparation method thereof
CN103751635A (en) * 2013-12-31 2014-04-30 青岛恒波仪器有限公司 Traditional Chinese medicine mask for treating chloasma and preparation method thereof
CN103751709A (en) * 2013-12-31 2014-04-30 青岛恒波仪器有限公司 Traditional Chinese medicinal composition for treating chloasma and preparation method thereof
CN104306661A (en) * 2014-10-31 2015-01-28 夏征梅 Traditional Chinese medicine for curing chloasma
CN106619238A (en) * 2016-11-07 2017-05-10 徐雪灵 Composition for treating chloasma
CN108324636A (en) * 2018-03-23 2018-07-27 北京明弘科贸有限责任公司 A kind of skin care compositions and with careful pore effect cosmetic, preparation method

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