CN104491152A - Medicine used for treating alopecia areata - Google Patents
Medicine used for treating alopecia areata Download PDFInfo
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- CN104491152A CN104491152A CN201510032246.1A CN201510032246A CN104491152A CN 104491152 A CN104491152 A CN 104491152A CN 201510032246 A CN201510032246 A CN 201510032246A CN 104491152 A CN104491152 A CN 104491152A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention relates to medicine used for treating alopecia areata. The medicine is composed of, by weight, 6 parts of polygonum multiflorum, 6 parts of radix rehmanniae preparata, 9 parts of eclipta alba and 5 parts of angelica sinensis. Both the polygonum multiflorum and the radix rehmanniae preparata in the formula enter the liver and kidney channels so as to nourish livers and kidneys, generate essence and nourish blood, and are main medicine for generating black hair. The eclipta alba nourishes yin and clears heat, and assists in blood nourishing and hair generation. The angelica sinensis removes stasis, promotes new, nourishes blood, promotes blood ciculation and assists in medicine nourishing and hair flourishing through the warm and smooth properties of the angelica sinensis. All the components are combined for use, supplement one another and have the liver tonifying, kidney tonifying, essence benefiting, blood nourishing and black hair generation functions together. The clinical experiment prompts that the medicine can be safely and effectively applied to the treatment of alopecia areata.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of Chinese medicine being used for the treatment of alopecia areata.
Background technology
Alopecia areata is a kind of non-cicatricial, diseases associated with inflammation of betiding hair follicle.With emergent circle or the alopecia of elliptical spot lamellar, alopecia district skin is normal, and no conscious sympton is feature.
The pathogenic factor of alopecia areata is still not clear.Have lymphocytic infiltration at perifollicolar, and primary disease merges other autoimmune diseasees (as vitiligo, atopic dermatitis) sometimes, therefore think that the generation of primary disease may exist autoimmune pathogenesis at present.Heredodiathesis is also a key factor, may be relevant to HLA II type, and the case of 25% has family history.In addition, also may be relevant with endocrine disturbance with traumatic nerve injury, psychological problem, infection focus.
The skin lesion of patients with alopecia areata shows as circle or the non-cicatricial alopecia of oval, at alopecia areata edge Chang Kejian " exclamation mark " sample hair.Hair comes off all or almost all, is called alopecia totalis.The all hair (comprising chaeta) of whole body all comes off, and is called general de-.Be also shown in row alopecia of crawling.Except without except hair, there are not other extremely in lesion skin.
The traditional Chinese medical science is called " alopecia areata ", " ghost licks head ", be commonly called as " alopecia areata ".The traditional Chinese medical science is thought, alopecia areata many genus blood deficiency can not nourish skin, sends out and loses nutrition and come off, or nervous, and depression of liver-QI is overworked, impairment caused by overstrain heart spleen, and the biochemical weary source of QI and blood, caused by hair mistake is supported; Or deficiency of the liver and kindey, blood and essence asthenia, unable hair care and cause alopecia.Treatment should control suitable nourishing blood to expel wind according to differentiation of symptoms and signs for classification of syndrome, vital energy regualting and blood circulation-promoting, liver and kidney tonifying respectively.
Medical material present Research involved in the present invention is as follows:
Radix Polygoni Multiflori [source] this product is the dried root of polygonum multiflorum thunb Polygonum multiflorum Thunb., and its rattan claims " Caulis Polygoni Multiflori ".Autumn, winter two excavate when season, leaf was withered, two ends of pruning, and clean, individual greatly be cut into block, dry.[process of preparing Chinese medicine] removing impurity, cleans, slightly soaks, run through, cut sheet or block, dry.[nature and flavor] are bitter, sweet, puckery, temperature.[return through] returns liver, the heart, kidney channel.[function cures mainly] detoxifies, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.[usage and dosage] 6 ~ 12g.[storage] puts dry place, mothproof.
Radix Rehmanniae Preparata [source] this product is the Preparation process product of Radix Rehmanniae.[nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.[usage and dosage] 6 ~ 15g.[storage] puts aeration-drying place.
Herba Ecliptae [source] this product is the dry aerial parts of feverfew Eclipta prostrata Eclipta prostrata L..Tap when the flowers are in blossom, dry.[process of preparing Chinese medicine] removing impurity, slightly washes, cutting, dries.[nature and flavor] are sweet, sour, cold.[return through] returns kidney, Liver Channel.[function cures mainly] nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.[usage and dosage] 6 ~ 12g.External fresh goods is appropriate.[storage] puts aeration-drying place.
Radix Angelicae Sinensis [source] this product is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.[process of preparing Chinese medicine] Radix Angelicae Sinensis: removing impurity, cleans, runs through, shave, dry or cold drying.[nature and flavor] sweet, acrid, warm.[return through] returns liver, the heart, spleen channel.[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.[usage and dosage] 6 ~ 12g.[storage] puts shady and cool dry place, moistureproof, mothproof.
Summary of the invention
The present invention aims to provide a kind of medicine being used for the treatment of alopecia areata, by selecting suitable medical material and proportioning thereof, reaches the safe and effective object being applied to alopecia areata treatment.
In order to achieve the above object, the present invention is by the following technical solutions:
Be used for the treatment of a medicine for alopecia areata, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Polygoni Multiflori 6 parts, 6 parts, Radix Rehmanniae Preparata, Herba Ecliptae 9 parts, Radix Angelicae Sinensis 5 parts.
Inventor, according to the Couple herbs had the deep influence of a scholarly family, understands the main idea that ancient books and records are discussed, and in conjunction with the pathological study of modern medicine to alopecia areata, sum up the present invention, in Fang Zhongfang, Radix Polygoni Multiflori, Radix Rehmanniae Preparata all enter Liver and kidney two warp, and with nourishing the liver and kidney, spermatogenesis nourishes blood, and are the principal agent of growing and blacking hair; Herba Ecliptae nourishing YIN and clearing away heat, helps the energy of blood nourishing and hair; Radix Angelicae Sinensis, eliminating blood stasis to promote regeneration of blood, nourshing blood and promoting blood circulation, with the property that its temperature is logical, nourishes the smooth Rong Maofa of medicine to help.All medicines share, and complement each other, and receive the liver and the kidney tonifying altogether, beneficial intensive culture blood, the merit that black one of the main divisions of the male role in traditional opera sends out.
Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:
1, physical data
Inventor collects 86 routine patients with alopecia areatas in June ,-2014 in March, 2013, is divided into 2 groups at random.Treatment group 43 people, male 28 people, female 15 people, age 18-55 year, 46.5 years old mean age, the course of disease 1 month-6 years; Matched group 43 people, male 30 people, female 13 people, age 19-56 year, 48.5 years old mean age, the course of disease 0.5 month-5.5 years.Two groups of Genders, age, courses of disease compare, and there is not significant difference, have comparability.
2, exclusion standard
(1) cicatricial alopecia;
Local hormone Drug therapy person was accepted in (2) 4 weeks;
(3) serious immunologic hypofunction person;
(4) life-time service 17-hydroxy-11-dehydrocorticosterone, immunosuppressant and use Loratadine and tranquilizer person;
(5) serious endocrinopathy person is suffered from;
(6) mental sickness and other infectious disease person is suffered from.
3, research method
3.1 Therapeutic Method
Treatment group takes the decoct that the present invention obtains according to specific embodiment 1, and every bu morning, noon and afternoon take for three times.
Injection with triamcinolone acetonide 0.1ml in matched group skin lesion, once a day, and oral oryzanol, each 0.2g, every day 3 times.
All treat 3 months for two groups.
Meals are taken good care of oneself: light, easy to digest, less salt, low fat diet, avoid and use pungent raw food, seafood stimulating food.
3.2 statistical method
Adopt SPSS18.0 statistics software data processing.
4, therapeutic outcome
4.1 criterion of therapeutical effect
Recovery from illness: alopecia areata district has whole terminal hair to grow, hair pulling test is negative;
Effective: alopecia areata district generally has kainogenesis long, hair stops coming off, terminal hair coverage rate >50%, and hair pulling test is negative;
Effective: alopecia areata district generally has kainogenesis long, hair stops coming off, terminal hair coverage rate <50%, and hair pulling test is negative or positive;
Invalid: only have a little kainogenesis long, hair continues to come off, hair pulling test is positive.
3.2 liang of group curative effects
After the treatment of 3 months, treatment group recovery from illness 20 example, effective 15 examples, effective 6 examples, invalid 2 examples, cure rate is 46.5%, and total effective rate is 95.3%; Matched group recovery from illness 10 example, effective 13 examples, effective 11 examples, no effect 9, cure rate is 23.3%, and total effective rate is 79.1%.There is significant significant difference, P<0.05 in two groups of cure rates, the cure rate for the treatment of group is significantly higher than matched group; Two groups of total effective rates compare, and treatment group total effective rate is significantly higher than matched group, P<0.05.
Visible, the medicine that the present invention obtains can safe and effective treatment alopecia areata, has good medical science promotional value.
Detailed description of the invention
In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
Embodiment 1
Take: Radix Polygoni Multiflori 6 grams, 6 grams, Radix Rehmanniae Preparata, Herba Ecliptae 9 grams, Radix Angelicae Sinensis 5 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.
Be used for the treatment of alopecia areata.Oral, every bu morning, noon and afternoon take for three times.
Embodiment 2
Take: Radix Polygoni Multiflori 6 grams, 6 grams, Radix Rehmanniae Preparata, Herba Ecliptae 9 grams, Radix Angelicae Sinensis 5 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.
Be used for the treatment of alopecia areata.Oral, daily once.
Embodiment 3
Take: Radix Polygoni Multiflori 6 grams, 6 grams, Radix Rehmanniae Preparata, Herba Ecliptae 9 grams, Radix Angelicae Sinensis 5 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.
Be used for the treatment of alopecia areata.Oral, every bu is taken for twice sooner or later.
Claims (1)
1. be used for the treatment of a medicine for alopecia areata, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Radix Polygoni Multiflori 6 parts, 6 parts, Radix Rehmanniae Preparata, Herba Ecliptae 9 parts, Radix Angelicae Sinensis 5 parts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510032246.1A CN104491152A (en) | 2015-01-23 | 2015-01-23 | Medicine used for treating alopecia areata |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510032246.1A CN104491152A (en) | 2015-01-23 | 2015-01-23 | Medicine used for treating alopecia areata |
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| CN104491152A true CN104491152A (en) | 2015-04-08 |
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| CN201510032246.1A Pending CN104491152A (en) | 2015-01-23 | 2015-01-23 | Medicine used for treating alopecia areata |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721584A (en) * | 2018-07-06 | 2018-11-02 | 周晓玲 | Anticreep black hair composition |
| CN113438952A (en) * | 2019-01-22 | 2021-09-24 | 李东琓 | Composition for preventing hair loss or promoting hair growth comprising a mixture of cucumber, eggplant and snail extracts as an active ingredient |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055023A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Radix rehmanniae recens for treating alopecia |
-
2015
- 2015-01-23 CN CN201510032246.1A patent/CN104491152A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055023A (en) * | 2013-01-10 | 2013-04-24 | 济南康众医药科技开发有限公司 | Radix rehmanniae recens for treating alopecia |
Non-Patent Citations (2)
| Title |
|---|
| 曾惠芳等: "《百子柜常用中草药正、别名手册》", 31 July 2005, 广东科技出版社 * |
| 高景华: "《名医珍藏药酒大全》", 30 April 2012, 陕西科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721584A (en) * | 2018-07-06 | 2018-11-02 | 周晓玲 | Anticreep black hair composition |
| CN108721584B (en) * | 2018-07-06 | 2021-08-03 | 周晓玲 | Hair loss preventing and hair blackening composition |
| CN113438952A (en) * | 2019-01-22 | 2021-09-24 | 李东琓 | Composition for preventing hair loss or promoting hair growth comprising a mixture of cucumber, eggplant and snail extracts as an active ingredient |
| CN113438952B (en) * | 2019-01-22 | 2022-10-25 | 李东琓 | Composition for preventing hair loss or promoting hair growth |
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Application publication date: 20150408 |
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