CN111973712A - Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof - Google Patents

Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof Download PDF

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CN111973712A
CN111973712A CN202010971817.9A CN202010971817A CN111973712A CN 111973712 A CN111973712 A CN 111973712A CN 202010971817 A CN202010971817 A CN 202010971817A CN 111973712 A CN111973712 A CN 111973712A
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parts
bath composition
treating psoriasis
chinese medicine
traditional chinese
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刘辉
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Beijing Tongchuntang Hospital Of Traditional Chinese Medicine General Partner
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Beijing Tongchuntang Hospital Of Traditional Chinese Medicine General Partner
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Abstract

The invention relates to a traditional Chinese medicine bath composition for treating psoriasis, a preparation method and application thereof, wherein the traditional Chinese medicine bath composition for treating psoriasis comprises the following raw material components: rhizoma atractylodis, cortex dictamni, fructus cnidii, fructus kochiae, radix sileris, safflower, dendrobe, rhizoma smilacis glabrae, folium artemisiae argyi, folium isatidis, radix sophorae flavescentis, cortex phellodendri, radix scrophulariae and borneol. The traditional Chinese medicine bath composition for treating psoriasis, provided by the invention, has the advantages of scientific and reasonable compatibility and simple preparation method, has better effects of clearing heat and promoting diuresis, dredging collaterals and regulating nutrient, dispelling wind and moistening dryness, relieving itching and promoting granulation, is assisted by medicated bath, can warm and dredge channels and collaterals and pass qi and blood by virtue of the combined action of temperature and medicines, and has a remarkable effect of improving clinical signs of psoriasis.

Description

Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof
Technical Field
The invention belongs to the technical field of traditional Chinese medicine bubble bath, and particularly relates to a traditional Chinese medicine bubble bath composition for treating psoriasis, and a preparation method and application thereof.
Background
Psoriasis is a common chronic, easily recurring inflammatory skin disease with characteristic lesions. The early stage is inflammatory red papule, about millet to mung bean in size, and then gradually expands or fuses into brownish red plaque with clear boundary, inflammatory red halo around the plaque, obvious substrate infiltration, and multiple layers of dry grey-white or silvery-white scales on the surface. The surface scale is scraped off slightly, and a layer of pale red and bright semitransparent film is gradually exposed, which is called the film phenomenon. When the film is scraped off, a small bleeding spot appears, which is called a spot bleeding phenomenon. White scales, shiny films and bleedings are important features for diagnosing psoriasis, called triple features. The skin lesions of psoriasis vulgaris can be roughly divided into three stages from occurrence to final regression: an advance period, a rest period, and a retreat period.
The traditional Chinese medicine considers that the main causes of psoriasis are wind-heat and dampness attacking the skin externally and entering the blood system to cause skin and blocking meridians, or caused by emotional disorder, fire transformation due to depression, improper diet, endogenous damp-heat, fire depression, deficiency of qi and blood for a long time, malnutrition of the skin of the meridians, dryness and desquamation. At present, more traditional Chinese medicines are used for treating the disease, but the truly effective scheme with breakthrough significance is less.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides the traditional Chinese medicine bubble bath composition for treating psoriasis and the preparation method thereof.
The technical scheme of the invention is as follows:
a traditional Chinese medicine bath composition for treating psoriasis comprises the following raw material components: rhizoma atractylodis, cortex dictamni, fructus cnidii, fructus kochiae, radix sileris, safflower, dendrobe, rhizoma smilacis glabrae, folium artemisiae argyi, folium isatidis, radix sophorae flavescentis, cortex phellodendri, radix scrophulariae and borneol.
Cang Zhu is pungent and bitter in flavor and warm in nature. Dry dampness and invigorate spleen, dispel wind and cold, improve vision. Can be used for treating damp obstruction of middle warmer, abdominal distention, diarrhea, edema, tinea pedis, atrophic debility cramped, rheumatalgia, wind-cold type common cold, night blindness, dim eyesight, and astringency.
Bai Xian Pi is bitter in taste and cold in nature. Clear heat and dry dampness, dispel wind and remove toxicity. Damp-heat sores, yellow water dripping, eczema, rubella, scabies, tinea, scabies, sores, scabies and arthralgia due to wind-damp-heat.
Cnidium fruit, pungent and bitter in flavor and warm in nature. Dry dampness and dispel wind, kill parasites and relieve itching, warm kidney and strengthen yang. Can be used for treating pruritus vulvae, leukorrhagia, eczema, pruritus, lumbago due to damp arthralgia, sexual impotence due to kidney deficiency, and infertility due to cold womb.
Di Fu Zi is pungent, bitter and cold in nature. Clear heat and promote diuresis, dispel wind and relieve itching. Can be used for treating difficult and painful urination, pruritus vulvae, leukorrhagia, rubella, eczema, and skin pruritus.
Fang Feng, pungent and sweet in flavor and slightly warm in nature. Dispel wind and relieve exterior syndrome, subdue dampness and alleviate pain, stop spasm. Can be used for treating exterior syndrome due to exogenous pathogenic factor, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency with excessive dampness.
Safflower, pungent in flavor and warm in nature. Promoting blood circulation, dredging channels, removing blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, thoracic obstruction, cardialgia, abdominal pain due to blood stasis, pricking pain in chest and hypochondrium, traumatic injury, and pyocutaneous disease with swelling and pain.
Dendrobium nobile is sweet in flavor and slightly cold in nature. Nourishing stomach, promoting the production of body fluid, nourishing yin and removing heat. It can be used for treating thirst due to consumption of body fluid, anorexia, constipation, deficiency heat, dim eyesight, and dim eyesight.
Smilax glabra, sweet and light in flavor, neutral in nature. Remove toxicity, remove dampness, and smooth joints. Can be used for treating limb spasm and arthralgia and myalgia due to syphilis and mercury poisoning; stranguria with turbid damp-heat, leukorrhagia, abscess, scrofula, scabies and tinea.
Mugwort leaf, pungent and bitter in flavor and warm in nature. Warming channels to stop bleeding, dispelling cold and relieving pain; externally used for eliminating dampness and relieving itching. Can be used for treating hematemesis, epistaxis, metrorrhagia, menorrhagia, fetal leakage, lower blood, lower abdomen psychroalgia, menoxenia, and infertility due to cold womb; it can be used for treating skin pruritus. Vinegar moxa charcoal can warm meridians and stop bleeding, and is indicated for bleeding due to deficiency-cold.
Da Qing Ye is bitter in taste and cold in nature. Clear heat and remove toxicity, cool blood and remove macula. Can be used for treating fever with polydipsia; unconsciousness; macula; hematemesis; bleeding; jaundice; diarrhea and dysentery; erysipelas; pharyngitis; aphtha; mumps.
Ku Shen is bitter in taste and cold in nature. Clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis.
Huang Bai is bitter in taste and cold in nature. Has the effects of clearing heat, eliminating dampness, purging fire, removing steam, removing toxic substance and treating sore. Can be used for treating dysentery due to damp-heat pathogen, jaundice, dark urine, leukorrhagia, pudendal pruritus, pyretic stranguria, pain, tinea pedis, atrophic debility cramped, hectic fever, night sweat, nocturnal emission, pyocutaneous disease, toxic swelling, eczema, and eczema. Salted cortex phellodendri is used for nourishing yin and reducing internal heat. Can be used for treating hyperactivity of fire due to yin deficiency, night sweat and steaming bone.
Xuan Shen is sweet, bitter, salty in flavor and slightly cold in nature. Clearing heat and cooling blood; nourishing yin to reduce pathogenic fire; detoxify and dissipate nodulation. Heat enters nutrient and blood in warm diseases; fever; polydipsia; a deep-red tongue; carrying out spot formation; bone steaming, strain cough; restlessness due to deficiency in the middle energizer; constipation due to body fluid impairment; eyes are astringent and dim; swollen and sore throat; scrofula and subcutaneous nodule; abscess, deep-rooted carbuncle and sore.
Borneol, pungent and bitter in flavor and slightly cold in nature. Induce resuscitation and refresh mind, clear heat and alleviate pain. Can be used for treating coma, sore throat, and aphtha of the mouth and tongue.
The traditional Chinese medicine bubble bath composition for treating psoriasis disclosed by the invention has the advantages that the rhizoma atractylodis, the cortex dictamni, the fructus cnidii, the fructus kochiae, the radix saposhnikoviae, the effects of clearing heat and drying dampness, dispelling wind and relieving exterior syndrome, the safflower is capable of activating blood and dissolving stasis, the dendrobe is capable of increasing the effect of cooling blood, the rhizoma smilacis glabrae is capable of strengthening and promoting diuresis, the folium artemisiae argyi is capable of clearing damp and relieving itching, and the folium isatidis, the radix sophorae flavescentis, the cortex phellodendri and the radix scrophulariae are capable of cooling blood and detoxifying.
Preferably, the traditional Chinese medicine bath composition for treating psoriasis comprises the following raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-20 parts of cortex dictamni, 10-20 parts of fructus cnidii, 10-20 parts of fructus kochiae, 10-20 parts of radix sileris, 10-20 parts of safflower, 10-20 parts of dendrobe, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of folium artemisiae argyi, 10-20 parts of folium isatidis, 10-20 parts of radix sophorae flavescentis, 10-20 parts of cortex phellodendri, 10-20 parts of radix scrophulariae and 10-20 parts of borneol.
Preferably, the traditional Chinese medicine bath composition for treating psoriasis comprises the following raw materials in parts by weight: 12-18 parts of rhizoma atractylodis, 12-18 parts of cortex dictamni, 12-18 parts of fructus cnidii, 12-18 parts of fructus kochiae, 12-18 parts of radix sileris, 12-18 parts of safflower carthamus, 12-18 parts of dendrobe, 12-18 parts of rhizoma smilacis glabrae, 12-18 parts of folium artemisiae argyi, 12-18 parts of folium isatidis, 12-18 parts of radix sophorae flavescentis, 12-18 parts of cortex phellodendri, 12-18 parts of radix scrophulariae and 12-18 parts of borneol.
Preferably, the traditional Chinese medicine bath composition for treating psoriasis comprises the following raw materials in parts by weight: 15 parts of rhizoma atractylodis, 15 parts of cortex dictamni, 15 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of radix saposhnikoviae, 15 parts of safflower carthamus, 15 parts of dendrobe, 15 parts of rhizoma smilacis glabrae, 15 parts of folium artemisiae argyi, 15 parts of folium isatidis, 15 parts of radix sophorae flavescentis, 15 parts of cortex phellodendri, 15 parts of radix scrophulariae and 15 parts of borneol.
The preparation method of the traditional Chinese medicine bath composition for treating psoriasis comprises the following steps: respectively taking raw materials except borneol, and sequentially removing impurities, cleaning, drying, crushing and sieving to obtain raw material fine powder; pulverizing Borneolum Syntheticum to obtain Borneolum Syntheticum powder; and uniformly mixing the fine powder of the raw materials and the borneol powder, and sterilizing to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Preferably, the drying temperature is 50-60 ℃, and the drying is carried out until the water content is less than 5%.
Preferably, the pulverization is to a particle size of 20 to 60 mesh, more preferably 40 mesh.
Preferably, the sterilization is radiation sterilization.
The composition of the invention is applied to the preparation of the medicine for treating psoriasis.
The using method of the traditional Chinese medicine bath composition comprises the following steps: soaking the Chinese medicinal bath composition in water (160 g:10000ml) for 5 hr, decocting with strong fire, boiling, decocting with slow fire for 1 hr, adding a small amount of warm water (no passing hip when sitting in the bathtub), adding the medicinal bath bag and medicinal liquid, controlling water temperature at about 40 deg.C, and bathing with boiling water when water temperature is too low. The medicine is taken once a day, and the bath is carried out for about 60 minutes every time, and 10 days are a treatment course.
The Chinese medicinal bath composition has the following cautions in use: 1. the bath should be avoided staying up all night, and the bath should be prevented if the user wants to prevent the common cold, and the bath can not be carried out on an empty stomach; 2. high temperature or low water bath is strictly forbidden; 3. the head and facial psoriasis can be wrapped on the head after soaking towel in the liquid medicine, or drenched with a small spoon without stopping, so that the liquid medicine does not flow into eyes and oral cavity; 4. the patient should not be grabbed and rubbed during bathing, and the patient should be naturally dried, and the patient should not be bathed within 5 hours, so that the patient is prevented from catching cold by wind, and serious illness is avoided; 5. avoiding the food of spicy, seafood, wine and obvious allergy; 6. the pregnant women and children can take the medicine with proper dosage reduction or follow the medical advice, and the medicine is forbidden in the menstrual period; 7. patients with severe heart failure, pulmonary insufficiency, coronary heart disease and hypertension, the elderly and children should be accompanied by medical care personnel, and the bath time should not be too long.
The invention has the beneficial effects that:
the traditional Chinese medicine bath composition for treating psoriasis provided by the invention is prepared by taking rhizoma atractylodis, cortex dictamni, fructus cnidii, fructus kochiae, radix sileris, safflower, dendrobe, rhizoma smilacis glabrae, folium artemisiae argyi, folium isatidis, radix sophorae flavescentis, cortex phellodendri, radix scrophulariae and borneol as raw materials and reasonably mixing the raw materials, and has good effects of clearing heat and promoting diuresis, dredging collaterals and regulating nutrient, dispelling wind and moistening dryness, relieving itching and promoting granulation. The composition is a skin external medicine, has no toxic or side effect on human bodies, is convenient to use, is not easy to relapse after healing, and is suitable for popularization and utilization.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.
Example 1
The embodiment provides a traditional Chinese medicine bath composition for treating psoriasis, which comprises the following raw materials in parts by weight: 15 parts of rhizoma atractylodis, 15 parts of cortex dictamni, 15 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of radix saposhnikoviae, 15 parts of safflower carthamus, 15 parts of dendrobe, 15 parts of rhizoma smilacis glabrae, 15 parts of folium artemisiae argyi, 15 parts of folium isatidis, 15 parts of radix sophorae flavescentis, 15 parts of cortex phellodendri, 15 parts of radix scrophulariae and 15 parts of borneol.
The preparation method comprises the following steps: respectively taking the raw materials except borneol, sequentially removing impurities, cleaning, drying at 50 ℃ until the water content is less than 5%, crushing to 40 meshes, and sieving to obtain fine powder of each raw material; pulverizing Borneolum Syntheticum into 40 mesh Borneolum Syntheticum powder; mixing the fine powder of the raw materials and the borneol powder uniformly, performing radiation sterilization, and bagging to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Example 2
The embodiment provides a traditional Chinese medicine bath composition for treating psoriasis, which comprises the following raw materials in parts by weight: 10 parts of rhizoma atractylodis, 20 parts of cortex dictamni, 10 parts of fructus cnidii, 20 parts of fructus kochiae, 10 parts of radix saposhnikoviae, 20 parts of safflower carthamus, 10 parts of dendrobe, 20 parts of rhizoma smilacis glabrae, 10 parts of folium artemisiae argyi, 20 parts of folium isatidis, 10 parts of radix sophorae flavescentis, 20 parts of cortex phellodendri, 10 parts of radix scrophulariae and 20 parts of borneol.
The preparation method comprises the following steps: respectively taking the raw materials except borneol, sequentially removing impurities, cleaning, drying at 50 ℃ until the water content is less than 5%, crushing to 20 meshes, and sieving to obtain fine powder of each raw material; pulverizing Borneolum Syntheticum into 20 mesh Borneolum Syntheticum powder; mixing the fine powder of the raw materials and the borneol powder uniformly, performing radiation sterilization, and bagging to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Example 3
The embodiment provides a traditional Chinese medicine bath composition for treating psoriasis, which comprises the following raw materials in parts by weight: 20 parts of rhizoma atractylodis, 10 parts of cortex dictamni, 20 parts of fructus cnidii, 10 parts of fructus kochiae, 20 parts of radix saposhnikoviae, 10 parts of safflower carthamus, 20 parts of dendrobe, 10 parts of rhizoma smilacis glabrae, 20 parts of folium artemisiae argyi, 10 parts of folium isatidis, 20 parts of radix sophorae flavescentis, 10 parts of cortex phellodendri, 20 parts of radix scrophulariae and 10 parts of borneol.
The preparation method comprises the following steps: respectively taking the raw materials except borneol, sequentially removing impurities, cleaning, drying at 60 ℃ until the water content is less than 5%, crushing to 60 meshes, and sieving to obtain fine powder of each raw material; pulverizing Borneolum Syntheticum into 60 mesh Borneolum Syntheticum powder; mixing the fine powder of the raw materials and the borneol powder uniformly, performing radiation sterilization, and bagging to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Example 4
The embodiment provides a traditional Chinese medicine bath composition for treating psoriasis, which comprises the following raw materials in parts by weight: 12 parts of rhizoma atractylodis, 18 parts of cortex dictamni, 12 parts of fructus cnidii, 18 parts of fructus kochiae, 12 parts of radix saposhnikoviae, 18 parts of safflower carthamus, 12 parts of dendrobe, 18 parts of rhizoma smilacis glabrae, 12 parts of folium artemisiae argyi, 18 parts of folium isatidis, 12 parts of radix sophorae flavescentis, 18 parts of cortex phellodendri, 12 parts of radix scrophulariae and 18 parts of borneol.
The preparation method comprises the following steps: respectively taking the raw materials except borneol, sequentially removing impurities, cleaning, drying at 60 ℃ until the water content is less than 5%, crushing to 40 meshes, and sieving to obtain fine powder of each raw material; pulverizing Borneolum Syntheticum into 40 mesh Borneolum Syntheticum powder; mixing the fine powder of the raw materials and the borneol powder uniformly, performing radiation sterilization, and bagging to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Example 5
The embodiment provides a traditional Chinese medicine bath composition for treating psoriasis, which comprises the following raw materials in parts by weight: 18 parts of rhizoma atractylodis, 12 parts of cortex dictamni, 18 parts of fructus cnidii, 12 parts of fructus kochiae, 18 parts of radix saposhnikoviae, 12 parts of safflower carthamus, 18 parts of dendrobe, 12 parts of rhizoma smilacis glabrae, 18 parts of folium artemisiae argyi, 12 parts of folium isatidis, 18 parts of radix sophorae flavescentis, 12 parts of cortex phellodendri, 18 parts of radix scrophulariae and 12 parts of borneol.
The preparation method comprises the following steps: respectively taking the raw materials except borneol, sequentially removing impurities, cleaning, drying at 60 ℃ until the water content is less than 5%, crushing to 40 meshes, and sieving to obtain fine powder of each raw material; pulverizing Borneolum Syntheticum into 40 mesh Borneolum Syntheticum powder; mixing the fine powder of the raw materials and the borneol powder uniformly, performing radiation sterilization, and bagging to obtain the traditional Chinese medicine bath composition for treating psoriasis.
Comparative example 1
The dendrobium is removed on the basis of the example 1, but the total amount of the raw materials is not changed, and specifically, the comparative example comprises the following raw materials in parts by weight: 18 parts of rhizoma atractylodis, 18 parts of cortex dictamni, 18 parts of fructus cnidii, 18 parts of fructus kochiae, 18 parts of radix saposhnikoviae, 15 parts of safflower carthamus, 15 parts of rhizoma smilacis glabrae, 15 parts of folium artemisiae argyi, 15 parts of folium isatidis, 15 parts of radix sophorae flavescentis, 15 parts of cortex phellodendri, 15 parts of radix scrophulariae and 15 parts of borneol.
Comparative example 2
The raw material ratio is changed on the basis of the example 1, and specifically, the comparative example comprises the following raw materials in parts by weight: 8 parts of rhizoma atractylodis, 8 parts of cortex dictamni, 22 parts of fructus cnidii, 22 parts of fructus kochiae, 15 parts of radix saposhnikoviae, 15 parts of safflower carthamus, 15 parts of dendrobe, 15 parts of rhizoma smilacis glabrae, 15 parts of folium artemisiae argyi, 15 parts of folium isatidis, 15 parts of radix sophorae flavescentis, 15 parts of cortex phellodendri, 15 parts of radix scrophulariae and 15 parts of borneol.
Evaluation of clinical efficacy
120 patients with psoriasis clinically diagnosed are selected, 66 men and 54 women, the age is distributed between 30 and 62 years, the average course is 6.5 years, 39 spotted lesions, 20 discs, 16 figures, 9 wheels and 36 mixed cases are selected. All patients were divided into control and treatment groups, treatment methods: control group: orally administered XIAOYINKE granule 3.5g for 3 times a day; treatment groups: the traditional Chinese medicine bubble bath composition for treating psoriasis in the embodiment or the comparative example is administered on the basis of the control group treatment method, and the using method of the traditional Chinese medicine bubble bath composition comprises the following steps: soaking the Chinese medicinal composition in water (160 g:10000ml) for 5 hr, decocting with strong fire, boiling, and decocting with slow fire for 1 hr; adding a small amount of warm water (only by sitting in a bathtub and passing over buttocks) into a bathtub or a bath barrel to be soaked, pouring the decocted medicinal liquid into the bathtub, controlling the water temperature at about 40 deg.C, and soaking, wherein when the water temperature is too low, boiled water can be added to adjust the temperature. The medicine is taken once a day, each time of soaking bath is 60 minutes, 10 days are taken as a treatment course, and 2 treatment courses are continuously performed.
PASI scoring: the human body was divided into 4 parts, namely, a head and neck part (occupying 10% of the body surface area), an upper limb (occupying 20% of the body surface area), a trunk (occupying 30% of the body surface area), and a lower limb (occupying 40% of the body surface area). And calculating the skin damage area integral and the severity degree of each, multiplying the results by respective coefficients, and finally adding the results to obtain the PASI total score. The erythema (E), the infiltration (I) and the scale (D) were examined and evaluated on a 0-4 point scale: 0 ═ none; 1 is mild; 2 is moderate; 3-severe; 4-very severe. Erythema (E): 0-no erythema visible; 1-is light red; 2-red; 3-deep red; 4-extremely deep red; infiltration (I): 0-skin lesions level with normal skin; 1-skin lesions are slightly elevated above normal skin surface; 2-moderate elevation, the edge of the plaque is round or slope type; 3-the skin is damaged and thickened and the bulge is obvious; 4-the skin damage is highly thickened, and the uplift is very obvious; scale (D): 0-no visible scale on the surface; 1-scale is covered on the surface of part of the skin damage, and the fine scale is taken as the main part; 2-most of the skin damage surfaces are completely or incompletely covered with scales which are flaky; 3-almost all the surface of the skin damage is covered with scale which is thicker and layered; 4-all the damaged surfaces are covered with scales, and the scales are thick and layered.
PASI score ═ head E + head I + head D × head a × 0.1+ (upper E + upper I + upper D) × upper a × 0.2+ (trunk E + trunk I + trunk D) × trunk a × 0.3+ (lower E + lower I + lower D) × lower a × 0.4.
And (3) healing: PASI integral drop > 93%; the effect is shown: the reduction is 60 to 92 percent; the method has the following advantages: the reduction is 30 to 59 percent; and (4) invalidation: the drop was < 30%. The results are shown in the following table.
TABLE 1 comparison of PASI scores before and after treatment
Figure BDA0002684359250000091
Compared with the contrast group, the ratio of the composition,*p<0.05,**p<0.01。
TABLE 2 comparison of the treatment results of two courses of treatment
Figure BDA0002684359250000092
The results show that compared with the control group, the PASI score of the treatment group 1 added with the traditional Chinese medicine bubble bath composition of the invention example 1 has very significant difference (p is less than 0.01), and is obviously superior to that of the control group, the treatment group 2 added with the traditional Chinese medicine bubble bath composition of the comparative example 1 and the treatment group 3 added with the traditional Chinese medicine bubble bath composition of the comparative example 2; the total treatment effect shows that the effective rate of the control group is 73.33 percent, the effective rate of the treatment group 1 is 96.67 percent, and the effective rates of the treatment group 2 and the treatment group 3 are 83.33 percent and 90.00 percent respectively, which shows that the composition has reasonable raw material proportion, and the raw materials are compatible with each other, thereby achieving better effect of adjuvant treatment of psoriasis.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims (10)

1. A traditional Chinese medicine bath composition for treating psoriasis is characterized by comprising the following raw material components: rhizoma atractylodis, cortex dictamni, fructus cnidii, fructus kochiae, radix sileris, safflower, dendrobe, rhizoma smilacis glabrae, folium artemisiae argyi, folium isatidis, radix sophorae flavescentis, cortex phellodendri, radix scrophulariae and borneol.
2. The traditional Chinese medicine bubble bath composition for treating psoriasis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10-20 parts of rhizoma atractylodis, 10-20 parts of cortex dictamni, 10-20 parts of fructus cnidii, 10-20 parts of fructus kochiae, 10-20 parts of radix sileris, 10-20 parts of safflower, 10-20 parts of dendrobe, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of folium artemisiae argyi, 10-20 parts of folium isatidis, 10-20 parts of radix sophorae flavescentis, 10-20 parts of cortex phellodendri, 10-20 parts of radix scrophulariae and 10-20 parts of borneol.
3. The traditional Chinese medicine bubble bath composition for treating psoriasis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 12-18 parts of rhizoma atractylodis, 12-18 parts of cortex dictamni, 12-18 parts of fructus cnidii, 12-18 parts of fructus kochiae, 12-18 parts of radix sileris, 12-18 parts of safflower carthamus, 12-18 parts of dendrobe, 12-18 parts of rhizoma smilacis glabrae, 12-18 parts of folium artemisiae argyi, 12-18 parts of folium isatidis, 12-18 parts of radix sophorae flavescentis, 12-18 parts of cortex phellodendri, 12-18 parts of radix scrophulariae and 12-18 parts of borneol.
4. The traditional Chinese medicine bubble bath composition for treating psoriasis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15 parts of rhizoma atractylodis, 15 parts of cortex dictamni, 15 parts of fructus cnidii, 15 parts of fructus kochiae, 15 parts of radix saposhnikoviae, 15 parts of safflower carthamus, 15 parts of dendrobe, 15 parts of rhizoma smilacis glabrae, 15 parts of folium artemisiae argyi, 15 parts of folium isatidis, 15 parts of radix sophorae flavescentis, 15 parts of cortex phellodendri, 15 parts of radix scrophulariae and 15 parts of borneol.
5. The method for preparing a Chinese medicinal bath composition for treating psoriasis according to any one of claims 1 to 4, which comprises the following steps: respectively taking raw materials except borneol, and sequentially removing impurities, cleaning, drying, crushing and sieving to obtain raw material fine powder; pulverizing Borneolum Syntheticum to obtain Borneolum Syntheticum powder; and uniformly mixing the fine powder of the raw materials and the borneol powder, and sterilizing to obtain the traditional Chinese medicine bath composition for treating psoriasis.
6. The method for preparing a Chinese medicinal bath composition for treating psoriasis according to claim 5, wherein the drying is carried out at a temperature of 50-60 ℃ until the water content is less than 5%.
7. The method for preparing a Chinese medicinal bath composition for treating psoriasis as claimed in claim 5, wherein the pulverizing is performed to a particle size of 20-60 mesh.
8. The method for preparing a Chinese medicinal bath composition for treating psoriasis as claimed in claim 7, wherein the pulverizing is performed to a particle size of 40 mesh.
9. The method for preparing a Chinese medicinal bath composition for treating psoriasis according to claim 5, wherein the sterilization is radiation sterilization.
10. Use of a Chinese medicinal bath composition according to any one of claims 1 to 4 in the manufacture of a medicament for the treatment of psoriasis.
CN202010971817.9A 2020-09-16 2020-09-16 Traditional Chinese medicine bath composition for treating psoriasis, preparation method and application thereof Pending CN111973712A (en)

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