CN108553620A - A kind of bacteriostasis spray and preparation method thereof for treating skin psoriasis - Google Patents
A kind of bacteriostasis spray and preparation method thereof for treating skin psoriasis Download PDFInfo
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Abstract
The invention discloses a kind of bacteriostasis sprays and preparation method thereof for treating skin psoriasis, belong to field of medicaments；Wherein the parts by weight of each component are 1 4.5 parts of kuh-seng, 1 3.5 parts of Radix Angelicae Sinensis, 1 2.5 parts of safflower, 1 3.5 parts of glutinous rehmannia, 1 4.5 parts of the coptis, 1 2.5 parts of Cortex Phellodendri, 1 2.5 parts of turmeric, 20 40 parts of castor oil, 23 parts of acetic acid chlorhexidine；Medicine for psoriasis bacteriostasis spray obtained have the function of it is antipruritic, removing toxic substances ecchymose removing, improve immunity, improve microcirculation and other effects, therapeutic effect is good, controls difficulty in relapse after healing, has no toxic side effect, be suitble to many patients use.
Description
Technical field
The present invention relates to a kind of sprays and preparation method thereof, and in particular to a kind of bacteriostasis spray that treating skin psoriasis and
Preparation method belongs to treatment skin psoriasis technical field.
Background technology
Psoriasis is commonly called as " psoriasis ", is a kind of and immune-related chronic recurrent inflammatory dermatoses.Psoriasis category
, can be by a variety of excitation conditions in multiple-factor inheritance disease, such as wound, infection, drug, spirit, food all may be susceptible
The disease is induced in individual.Characteristic lesions are to be covered with the multilayer silvery white scales of skin that peel off on red papules or patch, be apt to occur in four limbs stretch side,
Scalp and back, serious skin lesion can general hair whole body, and may occur in which high fever, warts, erythroderma sample change and the big Minor articulus of whole body
Lesion, initial stage typical lesions be red papules or maculopapule, syringe needle to mung bean size, clear border, overlying multilayer silvery white or
The mica sample scales of skin that peel off, the scales of skin that peel off are easy to strike off, and strike off the visible one layer of shinny pale red film i.e. film phenomenon of rear substrate, are scraped under continuing
There is small blutpunkte in erythema surface, can slowly expand or be fused into brownish red patch, with different degrees of itch, skin lesion is sent out well
Stretch side, elbow, knee, scalp and the small of the back in four limbs, this sick course of disease is long, the sustainable several years to many decades, during which can recurrent exerbation, sternly
Ghost image rings patient body health, therefore is paid attention to extensively by parent and medical circles.
Currently, the purpose of existing treatment technology is to control the state of an illness, slow down the process developed to whole body, mitigates subjective symptoms
And skin lesion, it avoids recurring as possible, improves patients ' life quality.Existing therapy has conjoint therapy, rotational therapy, sequence
Pass through with intermittent treatment etc., but generally existing therapeutic effect is bad, cure after easily recurrence, that the course for the treatment of is long, of high cost, side effect is big etc. is scarce
It falls into.Chinese medicine thinks：Kuh-seng heat-clearing and damp-drying drug, desinsection is antipruritic, antibacterial, anti-inflammatory, antiallergy；Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, ease constipation
Defaecation；Safflower, it is sweet in flavor, mild-natured, have effects that it is promoting blood circulation and removing blood stasis, dissipate and strongly fragrant open knot；Radix rehmanniae recen clearing heat and cooling blood, nourishing Yin and promoting production of body fluid is calm,
It is anti-inflammatory, antiallergy；Coptis heat-clearing and damp-drying drug, purging intense heat and detonicating is antibacterial, antiallergy；Cortex Phellodendri heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment；
Turmeric blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic；Castor oil bitter purging intense heat, except steaming cool in nature, detoxification sore treatment.
Chinese medicine think psoriasis be ailment said due to cold or exposure poison in skin, delay do not go, penting up heat, excess heat is then dry, dry very then to cause blood
Accumulate in heat or prolonged illness ferritic weakness, wind-dryness, consume caused by impairment of yin blood, venation block, failure of skin and muscle to be nourished.Chinese medicine is particular about conditioning, and sample is simultaneous
It controls, the effective agent of research psoriasis based on traditional Chinese medicine, energy expelling wind and clearing away heat, removing pattogenic heat from the blood and toxic material from the body, nourishing Yin and moistening dryness, removing toxic substances stagnation resolvation,
It is of great significance to improving patient health level.The selected wherein above-mentioned Chinese medicine of the present invention, and Western medicine chlorhexidine acetate system is added
It is standby and obtain, can reach clearing heat and cooling blood, removing toxic substances ecchymose removing, nourishing the blood and yin, moisturizing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., be promoting blood circulation and removing blood stasis, dispelling toxins and dredging collaterals, clearing heat-fire,
Rapid antipruritic, raising immunity, the function of improving microcirculation, are suitable for various types of psoriasis.
Invention content
The purpose of the present invention in order to solve the problems, such as the treatment of current skin psoriasis, and propose it is a kind of treat skin silver bits
The bacteriostasis spray of disease；To achieve the above object, the present invention adopts the following technical scheme that：
A kind of bacteriostasis spray for treating skin psoriasis, the parts by weight of each component are：
1-4.5 parts of kuh-seng, 1-3.5 parts of Radix Angelicae Sinensis, 1-2.5 parts of safflower, 1-3.5 parts of glutinous rehmannia, 1-4.5 parts of the coptis, 1-2.5 parts of Cortex Phellodendri,
1-2.5 parts of turmeric, 20-40 parts of castor oil, 2-3 parts of acetic acid chlorhexidine.
3-4.5 parts of kuh-seng, 1-2.5 parts of Radix Angelicae Sinensis, 2-2.5 parts of safflower, 1-2 parts of glutinous rehmannia, 3-4.5 parts of the coptis, 1-2 parts of Cortex Phellodendri,
2-2.5 parts of turmeric, 20-30 parts of castor oil, 2-2.5 parts of acetic acid chlorhexidine.
1-2.5 parts of kuh-seng, 2-3.5 parts of Radix Angelicae Sinensis, 2-2.5 parts of safflower, 2.5-3.5 parts of glutinous rehmannia, 1-2.5 parts of the coptis, Cortex Phellodendri
1.5-2.5 parts, 2-2.5 parts of turmeric, 30-40 parts of castor oil, 2.5-3 parts of acetic acid chlorhexidine.
3.5-4.5 parts of kuh-seng, 2.5-3 parts of Radix Angelicae Sinensis, 1-2 parts of safflower, 1.5-3 parts of glutinous rehmannia, 2.5-3.5 parts of the coptis, Cortex Phellodendri 2-
2.5 parts, 1-2 parts of turmeric, 25-35 parts of castor oil, 2-2.5 parts of acetic acid chlorhexidine.
A kind of bacteriostasis spray preparation method for treating skin psoriasis, includes the following steps：
（1）Each raw material is weighed, it is spare；
（2）Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric extract 1h with 75% ethyl alcohol, obtain alcohol extract and the dregs of a decoction；
（3）It will（2）The dregs of a decoction described in step merge with kuh-seng, Radix Angelicae Sinensis, safflower, and after being ground into fine powder with pulverizer, it is total that medicinal material is added
The deionized water of 10 times of amounts of weight decocts 2-3h, and filtering obtains water extract；
（4）The alcohol extract and the water extract are mixed, concentration obtains concentrate；
（5）Castor oil, acetic acid chlorhexidine are added in concentrate and are heated to 50-60 DEG C, cooling is eventually fabricated spray.
The principles of formulating prescriptions of the present invention are：
Nourishing liver and spleen, replenish qi to invigorate the spleen, nourshing blood and promoting blood circulation, clearing and activating the channels and collaterals, promoting blood circulation and removing blood stasis, righting are got rid of evils, adjust immune function, improve skin
Skin microcirculation achievees the purpose that treat psoriasis.
The action and efficacy of each component is as follows：
Kuh-seng：Bitter, cold in nature, the thoughts of returning home, liver, stomach, large intestine, bladder warp；Heat-clearing and damp-drying drug, desinsection, diuresis.
Radix Angelicae Sinensis：It enriches blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.The main all cards of the deficiency of blood；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Abdominal mass knot
It is poly-；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Numbness；Intestines are dry and shit is difficult；Weight after dysentery characterized by blood in the stool；Ulcer sores；Injury from falling down.
Safflower：It is acrid in flavour and warm in nature；Enter the heart, Liver Channel, invigorate blood circulation, stasis eliminatings analgesic.Controlling through closing, abdominal mass, difficult labour, stillborn foetus, lochia
Not all right, hemostasis is had a pain, carbuncle swells, injury from falling down.
Glutinous rehmannia：Fresh rehmannia root：It is sweet, bitter, it trembles with fear.Radix rehmanniae recen：It is sweet, it trembles with fear.Prepared rehmannia root：It is sweet, tepor；The thoughts of returning home, liver and kidney channel；Glutinous rehmannia property
It is cool, sweet-bitter flavor, have effects that enriching yin and nourishing kidney, blood-nourishing enrich blood, cool blood.Have cardiac stimulant diuresis, antipyretic anti-inflammatory, promote blood clotting and
Reduce the effect of blood glucose.
The coptis：Heat-clearing and damp-drying drug, purging intense heat and detonicating.For damp and hot feeling of fullness, acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, internal heat are vomitted
High Sheng, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, toothache are quenched one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.
Cortex Phellodendri：Bitter, it is cold in nature；Return kidney, bladder warp；For damp-heat dysentery, jaundice, with lower pruritus vulvae, puckery pain of heat gonorrhea, foot
Gas impotence is preesed, hectic fever due to yin labor heat, night sweat, seminal emission, sore swollen toxin, eczema wet sore.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing yin and lessening fire.For fire excess from yin deficiency, night sweat
Hectic fever due to yin.
Turmeric：It is arduous, temperature；Blood-breaking, promoting the circulation of qi, promoting menstruation, analgesic.Control trusted subordinate's feeling of fullness distending pain, brachialgia, abdominal mass, women's blood stasis warp
It closes, the postpartum stasis of blood stops abdominal pain, injury from falling down, carbuncle swells.
Castor oil：Bitter, cool in nature, purging intense heat, except steaming, detoxification sore treatment；
Chlorhexidine acetate：Also it is Robenidine Roripa, chlorhexidine acetate, Chlorhexidine, double benzyl chloride chlorhexidine, for cation
Surfactant, has a broad antifungal spectrum have killing effect to most Grain-positives and negative bacteria, also effective to Pseudomonas aeruginosa；With
In operation remote holder, skin, planing surface and sterilization of instruments.
The invention has the advantages that：
This medicine for psoriasis bacteriostasis spray is the understanding and principle of reatment with doctor trained in Western medicine to pathogenesis of acne mechanism based on modern Chinese medicine, in selected
Western medicine drug raw material, is formulated using unique formula, when treatment, external application, and this appropriate reagent of alignment affected part sprinkling, once a day
Or twice, a month as a course for the treatment of；It takes effect within usual one month, can cure within 1~5 month, furfur, antipruritic effect are good, after healing not
Easily recurrence, has no toxic side effect.
Specific implementation mode
The present invention is described in further details below by embodiment, these embodiments are only used for illustrating the present invention, and
It does not limit the scope of the invention.
Embodiment 1
A kind of bacteriostasis spray for treating skin psoriasis, the parts by weight of each component are：
2 parts of kuh-seng, 3.5 parts of Radix Angelicae Sinensis, 1 part of safflower, 3.5 parts of glutinous rehmannia, 1 part of the coptis, 2.5 parts of Cortex Phellodendri, 1 part of turmeric, 40 parts of castor oil,
2 parts of acetic acid chlorhexidine；
A kind of bacteriostasis spray preparation method for treating skin psoriasis, includes the following steps：
（1）Each raw material is weighed, it is spare；
（2）Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric extract 1h with 75% ethyl alcohol, obtain alcohol extract and the dregs of a decoction；
（3）It will（2）The dregs of a decoction described in step merge with kuh-seng, Radix Angelicae Sinensis, safflower, and after being ground into fine powder with pulverizer, it is total that medicinal material is added
The deionized water of 10 times of amounts of weight decocts 2-3h, and filtering obtains water extract；
（4）The alcohol extract and the water extract are mixed, concentration obtains concentrate；
（5）Castor oil, acetic acid chlorhexidine are added in concentrate and are heated to 50-60 DEG C, cooling is eventually fabricated spray.
Embodiment 2
3 parts of kuh-seng, 2.5 parts of Radix Angelicae Sinensis, 2 parts of safflower, 2 parts of glutinous rehmannia, 3 parts of the coptis, 2 parts of Cortex Phellodendri, 2 parts of turmeric, 20 parts of castor oil, acetic acid
2.5 parts of chlorhexidine；
A kind of bacteriostasis spray preparation method for treating skin psoriasis, includes the following steps：
（1）Each raw material is weighed, it is spare；
（2）Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric extract 1h with 75% ethyl alcohol, obtain alcohol extract and the dregs of a decoction；
（3）It will（2）The dregs of a decoction described in step merge with kuh-seng, Radix Angelicae Sinensis, safflower, and after being ground into fine powder with pulverizer, it is total that medicinal material is added
The deionized water of 10 times of amounts of weight decocts 2-3h, and filtering obtains water extract；
（4）The alcohol extract and the water extract are mixed, concentration obtains concentrate；
（5）Castor oil, acetic acid chlorhexidine are added in concentrate and are heated to 50-60 DEG C, cooling is eventually fabricated spray.
Embodiment 3
2.5 parts of kuh-seng, 3.5 parts of Radix Angelicae Sinensis, 2.5 parts of safflower, 2.5 parts of glutinous rehmannia, 1 part of the coptis, 1.5 parts of Cortex Phellodendri, 2.5 parts of turmeric, castor-oil plant
Oily 35 parts, acetic acid chlorhexidine part；
（1）Each raw material is weighed, it is spare；
（2）Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric extract 1h with 75% ethyl alcohol, obtain alcohol extract and the dregs of a decoction；
（3）It will（2）The dregs of a decoction described in step merge with kuh-seng, Radix Angelicae Sinensis, safflower, and after being ground into fine powder with pulverizer, it is total that medicinal material is added
The deionized water of 10 times of amounts of weight decocts 2-3h, and filtering obtains water extract；
（4）The alcohol extract and the water extract are mixed, concentration obtains concentrate；
（5）Castor oil, acetic acid chlorhexidine are added in concentrate and are heated to 50-60 DEG C, cooling is eventually fabricated spray.
Clinical data：The drug of the present invention treats patient 242 altogether, wherein man 150, female 92 is all made of embodiment
Drug therapy prepared by 1-3, when treatment, sprinkling this appropriate reagent in alignment affected part once a day or is twice treated for one month for one
Journey.After treating three courses for the treatment of, cure (fash subside or subside completely 90% or more) 162, it is effective (deflorescence 60% with
On) 46 (this 45 effective patients, and continue 2 courses for the treatment of of medication, cure mostly), effective (30% or more deflorescence) 22
Example, invalid (below deflorescence 30%) 12, cure rate have reached 67%, and total effective rate is up to 95%.It is returned after healing person's half a year
It visits, there is 13 recurrences, remaining no relapse.All patients have no adverse reaction during treatment.
Case 1：Luo, man, 26 years old, medical history 6 years, no family history, the de- white scurf of the visible lower limb of physical examination, itch was very acute
Cloth is diagnosed as psoriasis.Drug (preparation of embodiment 1) using the present invention treatment, when treatment, this appropriate examination of alignment affected part sprinkling
Agent, twice a day, a month as a course for the treatment of.After treatment 15 days, symptom mitigates；After 1 month, symptom mitigates significantly, and itch becomes micro-
Itch；After 2 months, affected skin returns to normal, no pruritis, cures.To consolidate curative effect, patient receives a treatment again
The treatment of journey.It is paid a return visit after half a year, no relapse.
Case 2：Wu so-and-so, female, 32 years old, medical history 3 years, no family history, the de- white scurf of the visible lower limb of physical examination, itch was very acute
Cloth is diagnosed as psoriasis.Drug (preparation of embodiment 1) using the present invention treatment, when treatment, this appropriate examination of alignment affected part sprinkling
Agent, twice a day, a month as a course for the treatment of.After treatment 10 days, symptom mitigates；After 1 month, affected skin returns to normal,
Without pruritis, cure.It is paid a return visit after half a year, no relapse.
The above is only the application implementation mode of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of bacteriostasis spray for treating skin psoriasis, which is characterized in that the parts by weight of each component are：
1-4.5 parts of kuh-seng, 1-3.5 parts of Radix Angelicae Sinensis, 1-2.5 parts of safflower, 1-3.5 parts of glutinous rehmannia, 1-4.5 parts of the coptis, 1-2.5 parts of Cortex Phellodendri,
1-2.5 parts of turmeric, 20-40 parts of castor oil, 2-3 parts of acetic acid chlorhexidine.
2. a kind of bacteriostasis spray for treating skin psoriasis, which is characterized in that the parts by weight of each component are：
3-4.5 parts of kuh-seng, 1-2.5 parts of Radix Angelicae Sinensis, 2-2.5 parts of safflower, 1-2 parts of glutinous rehmannia, 3-4.5 parts of the coptis, 1-2 parts of Cortex Phellodendri, turmeric
2-2.5 parts, 20-30 parts of castor oil, 2-2.5 parts of acetic acid chlorhexidine.
3. a kind of bacteriostasis spray for treating skin psoriasis, which is characterized in that the parts by weight of each component are：
1-2.5 parts of kuh-seng, 2-3.5 parts of Radix Angelicae Sinensis, 2-2.5 parts of safflower, 2.5-3.5 parts of glutinous rehmannia, 1-2.5 parts of the coptis, Cortex Phellodendri 1.5-2.5
Part, 2-2.5 parts of turmeric, 30-40 parts of castor oil, 2.5-3 parts of acetic acid chlorhexidine.
4. a kind of bacteriostasis spray for treating skin psoriasis, which is characterized in that the parts by weight of each component are：
3.5-4.5 parts of kuh-seng, 2.5-3 parts of Radix Angelicae Sinensis, 1-2 parts of safflower, 1.5-3 parts of glutinous rehmannia, 2.5-3.5 parts of the coptis, Cortex Phellodendri 2-2.5
Part, 1-2 parts of turmeric, 25-35 parts of castor oil, 2-2.5 parts of acetic acid chlorhexidine.
5. a kind of bacteriostasis spray for treating skin psoriasis, it is characterised in that：There is the bacteriostasis spray clearing heat and cooling blood, removing toxic substances to disappear
Spot, nourishing the blood and yin, moisturizing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., be promoting blood circulation and removing blood stasis, dispelling toxins and dredging collaterals, clearing heat-fire, it is rapid it is antipruritic, improve immunity, improve micro- follow
The function of ring is suitable for various types of psoriasis.
6. a kind of bacteriostasis spray preparation method for treating skin psoriasis, includes the following steps：
（1）Each raw material is weighed, it is spare；
（2）Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric extract 1h with ethyl alcohol, obtain alcohol extract and the dregs of a decoction；
（3）It will（2）The dregs of a decoction described in step merge with kuh-seng, Radix Angelicae Sinensis, safflower, and after being ground into fine powder with pulverizer, it is total that medicinal material is added
The deionized water of 10 times of amounts of weight decocts 2-3h, and filtering obtains water extract；
（4）The alcohol extract and the water extract are mixed, concentration obtains concentrate；
（5）Castor oil, acetic acid chlorhexidine are added in concentrate and are heated to 50-60 DEG C, cooling is eventually fabricated spray.
7. according to the method described in claim 6, it is characterized in that：The bacteriostasis spray is to be added to Western medicine chlorhexidine acetate system
Obtained from standby.
8. according to the method described in claim 6, it is characterized in that：Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric are carried with 75% ethyl alcohol
It takes.
9. according to the method described in claim 6, it is characterized in that：Glutinous rehmannia, the coptis, Cortex Phellodendri and turmeric are extracted with 75% ethyl alcohol
The dregs of a decoction afterwards will continue to be extracted with water.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109224037A (en) * | 2018-11-19 | 2019-01-18 | 通化市广海生物科技有限公司 | A kind of antibacterial cream of erysipelas and preparation method thereof |
| CN112402575A (en) * | 2020-11-25 | 2021-02-26 | 北京同春堂中医医院(普通合伙) | External ointment for treating psoriasis and preparation method thereof |
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| TW201124152A (en) * | 2010-01-06 | 2011-07-16 | Chao-Ho Liu | Compounds prescription of Chinese herbal medicine used to cure psoriasis and medical composition containing same. |
| CN105878552A (en) * | 2016-06-03 | 2016-08-24 | 南通大学附属医院 | Traditional Chinese medicine preparation for treating psoriasis |
| CN107260795A (en) * | 2017-06-26 | 2017-10-20 | 刘骞 | A kind of antibacterial ointment of medicine for psoriasis |
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2018
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| TW201124152A (en) * | 2010-01-06 | 2011-07-16 | Chao-Ho Liu | Compounds prescription of Chinese herbal medicine used to cure psoriasis and medical composition containing same. |
| CN105878552A (en) * | 2016-06-03 | 2016-08-24 | 南通大学附属医院 | Traditional Chinese medicine preparation for treating psoriasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109224037A (en) * | 2018-11-19 | 2019-01-18 | 通化市广海生物科技有限公司 | A kind of antibacterial cream of erysipelas and preparation method thereof |
| CN112402575A (en) * | 2020-11-25 | 2021-02-26 | 北京同春堂中医医院(普通合伙) | External ointment for treating psoriasis and preparation method thereof |
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