CN105560363A

CN105560363A - Traditional Chinese medicine external ointment for treating psoriasis and preparation method of traditional Chinese medicine external ointment

Info

Publication number: CN105560363A
Application number: CN201410620178.6A
Authority: CN
Inventors: 王竞波
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-11-07
Filing date: 2014-11-07
Publication date: 2016-05-11

Abstract

The invention discloses a traditional Chinese medicine external ointment for treating psoriasis. The traditional Chinese medicine external ointment consists of the following raw medical materials in parts by weight: 9-11 parts of ginseng, 1-3 parts of musk, 4-6 parts of safflower, 4-6 parts of calculus bovis, 9-11 parts of borneol, 9-11 parts of mint, 4-6 parts of alumen, 0.4-0.8 part of calomel and 4-6 parts of acacia catechu. A preparation method for the traditional Chinese medicine external ointment comprises the following steps: taking 9-11 parts of ginseng, 1-3 parts of musk, 4-6 parts of safflower, 4-6 parts of calculus bovis, 9-11 parts of borneol, 9-11 parts of mint, 4-6 parts of alumen, 0.4-0.8 part of calomel and 4-6 parts of acacia catechu; taking musk, calculus bovis, borneol, mint, alumen, calomel and acacia catechu from the 9 medical materials, respectively grinding musk, calculus bovis, borneol, mint, alumen, calomel and acacia catechu into fine powder I, and uniformly mixing; processing ginseng and safflower with wine, grinding into coarse powder, then percolating with 50% ethyl alcohol, collecting medical liquid, recycling ethyl alcohol, concentrating and drying, and grinding into fine powder II; uniformly mixing the fine powder I and the fine powder II, sieving with a 100-mesh sieve, adding vaseline, and uniformly mixing so as to obtain the external ointment. The traditional Chinese medicine external ointment is particularly suitable for treating various types of psoriasis and intractable psoriasis.

Description

One treats psoriasic external Chinese medicinal ointment and preparation method thereof

Technical field:

The present invention relates to one and treat psoriasic external Chinese medicinal ointment and preparation method thereof, belong to pharmaceutical technology sectors.

Technical background

Psoriasis is clinical middle a kind of common dermatosis, brings great misery, the serious health that have impact on people to patient.Current modern medicine to the treatment of this disease mainly based on anti-inflammatory agent, hormone, Chinese patent medicine, all can only relief of symptoms, what have also has serious toxic and side effects; Also be of no curative effect medicine at present that significantly maybe can eradicate.Therefore, develop a kind of cure rate high, do not recur more, safety, the medicine had no side effect becomes urgent need.In order to address this problem, people have done multiple effort, as No. 200710072505.9, Chinese patent discloses a key name and be called the technology of " one treats psoriasic Chinese medicine ", the present inventor through one of prescription studying treatment psoriasis for many years, although effective for treatment psoriasis, but in the process of curing the disease, find that production technology is comparatively thick in recent years, cause stability of drug products poor, the problems such as utilization rate of active components is low.For solving the defect existing for above-mentioned prior art, in the time in recent years, in conjunction with a large amount of Study on clinical pharmacodynamics, on the basis of existing formula and technique, groped by a large amount of experiments, after its formula and technique are improved, clinical pharrnacokinetics experiment effect significantly improves, and technique is more reasonable, and effective ingredient content is high, safe and without any side effects, cure psoriasis and sclerodermatous effective percentage reaches 100%.

Summary of the invention

In order to overcome the deficiencies in the prior art, the invention provides one and can effect a radical cure psoriasic external Chinese medicinal ointment and preparation method thereof.The crude drug weight proportion of Chinese medicinal ointment: Radix Ginseng 9-11 part, Moschus 1-3 part, Flos Carthami 4-6 part, Calculus Bovis 4-6 part, Borneolum Syntheticum 9-11 part, Herba Menthae 9-11 part, Alumen 4-6 part, Calomelas 0.4-0.8 part, Catechu 4-6 part, preparation method is: above nine taste medical materials, get Moschus, Calculus Bovis, Borneolum Syntheticum, Herba Menthae, Alumen, Calomelas, Catechu be ground into fine powder, mix homogeneously respectively; Processed with wine Radix Ginseng, processed with wine Flos Carthami powder are broken into coarse powder, then carry out percolation with 50% ethanol, collect medicinal liquid, reclaim ethanol concentrate drying and are ground into fine powder; By above all fine powders mixing, add after crossing 100 mesh sieves vaseline mixing external-applied ointment.The present invention is with Radix Ginseng strongly invigorating primordial QI, prebiotic Tianjin, with fixed attention Fructus Alpiniae Oxyphyllae; Flos Carthami, promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing; Catechu promoting tissue regeneration and ulcer healing, analgesic therapy Anti-Puritic and insecticidal; Moschus, Borneolum Syntheticum, Herba Menthae are had one's ideas straightened out in skin muscular, promoting blood circulation to restore menstrual flow network, pain relieving, antipruritic, dissipating blood stasis heat clearing away; Calculus Bovis inducing resuscitation and resolving phlegm, heat-clearing and toxic substances removing, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion; Alumen external dampness restrains; Calomelas external parasite killing counteracting toxic substances; Alumen astringent therapy removing toxic substances parasite killing; Catechu heat clearing away, sore hemostasis, analgesic therapy Anti-Puritic and insecticidal have inhibitory action in various degree to various dermatophytes; The result of above-mentioned every medicine comprehensive function makes the present invention have, and antipruritic removing dampness relieves dizziness, high fever, infantile convulsions, epilepsy, etc., the effect of blood circulation promoting and blood stasis dispelling, removing heat from blood mind calming, detoxification dispelling wind for relieving itching; The present invention adopts new composition and engineering, and clinical pharrnacokinetics experiment effect significantly improves, and technique is more reasonable, and effective ingredient content is high, safe and without any side effects, cures psoriasis and sclerodermatous effective percentage reaches 100%.

Detailed description of the invention:

A most preferred embodiment of the present invention, gets Radix Ginseng 11g, Moschus 1g, Flos Carthami 4g, Calculus Bovis 4g, Borneolum Syntheticum 9g, Herba Menthae 9g, Alumen 4g, Calomelas 0.4g, Catechu 4g.Preparation method is: above nine taste medical materials, gets Moschus, Calculus Bovis, Borneolum Syntheticum, Herba Menthae, Alumen, Calomelas, Catechu be ground into fine powder, mix homogeneously respectively; Processed with wine Radix Ginseng, processed with wine Flos Carthami powder are broken into coarse powder, then carry out percolation with 50% ethanol, collect medicinal liquid, reclaim ethanol concentrate drying and are ground into fine powder; By above all fine powders mixing, add after crossing 100 mesh sieves vaseline mixing external-applied ointment.

The embodiment of of the present invention second, gets Radix Ginseng 9g, Moschus 3g, Flos Carthami 6g, Calculus Bovis 6g, Borneolum Syntheticum 11g, Herba Menthae 11g, Alumen 6g, Calomelas 0.8g, Catechu 6g.Preparation method is: above nine taste medical materials, gets Moschus, Calculus Bovis, Borneolum Syntheticum, Herba Menthae, Alumen, Calomelas, Catechu be ground into fine powder, mix homogeneously respectively; Processed with wine Radix Ginseng, processed with wine Flos Carthami powder are broken into coarse powder, then carry out percolation with 50% ethanol, collect medicinal liquid, reclaim ethanol concentrate drying and are ground into fine powder; By above all fine powders mixing, add after crossing 100 mesh sieves vaseline mixing external-applied ointment.

Evaluate the clinical medicine safety of Chinese medicine of the present invention, toxicity test research carried out to it, has been reported as follows:

One treats every medicine homomixture 10 grams in psoriasic Chinese medicine formula.Experimental animal is the white mice of Kunming kind, body weight 18-22 gram, male and female dual-purpose.By 4 times of people's consumption every day, medicine is mixed in feedstuff, weigh in respectively before and after feeding, often observe mouse diet in administration process, enliven situation and coat condition, administration is the no abnormal change of observed result after continuous ten days, illustrates that one is treated psoriasic Chinese medicine and had safety.

One treats psoriasic Chinese medicine clinical experiment report:

1, physical data, select psoriatic 59 example of in April, 2013 out-patient treatment in February ,-2014, wherein man 43 example, female 16 example, age 40-50 year 10 example, 51-60 year 30 examples, more than 61 years old 19 is routine, and wherein Therapeutic Method at random patient is divided into two groups, treatment group 39 example, smearing the present invention and treat psoriasic Chinese medicine ointment, every day twice, 60 days is a course for the treatment of.Matched group 20 example, using other medicine, 60 days is a course for the treatment of; Withdraw other medicines before treatment group administration, all check before and after treatment, it is 100% that result shows to smear the treatment group effective percentage that the present invention treats psoriasic Chinese medicine ointment, and matched group effective only account for 50%.

2, criterion of therapeutical effect (1) recovery from illness: treat 1 course for the treatment of, pain symptom disappears, and local is red and swollen to disappear, and skin color is normal; (2) take a turn for the better: treat 2 courses for the treatment of, pain symptom obviously alleviates, and red swelling of the skin burning pain does not disappear completely; (3) do not heal: treat 3 courses for the treatment of, local inflammation is not still felt any better, and also without increasing the weight of, pain is without alleviation.To cure+to take a turn for the better statistics effective percentage; Disappear with local redness, obviously the time of alleviating is the drug effect time to private prosecution pain.

3, observation item close observation record the time that psoriatic's temperature recovery is normal, pain disappears; Close observation psoriatic has no adverse reaction, and a situation arises, and give anti symptom treatment in time.

4, the routine psoriatic of Therapeutic Method treatment group 39 uses external application medical ointment of the present invention, external application medical ointment is evenly coated in thick about 2mm on double gauze, spreads on affected part outward, area is slightly larger than disease damage place, cover layer 2-3 gauze loosely to wrap up, with immobilization with adhesive tape, change dressings every day 1 time; It is for 2 times 1 course for the treatment of; It is a course for the treatment of that matched group psoriatic uses existing Chinese medicinal ointment two groups to be 60 days.

5, comparitive study after the course for the treatment of of therapeutic outcome two groups for the treatment of groups, treatment group 39 example, wherein cures 39 routine effective percentage 100%; Matched group 20 example, wherein effective 10 examples (50%), invalid 10 examples (50%), effective percentage 50%; Treatment group cure rate, effective percentage, apparently higher than matched group, have significant difference, have statistical significance (P < 0.05).

6, observe discovery in untoward reaction therapeutic process, matched group has 5 routine psoriatics to occur skin pruritus phenomenon; The treatment group situation that has no adverse reaction occurs, and illustrates that liniment of the present invention is safe and reliable, has no side effect, and the psoriatic being applicable to any age uses.

Claims

1. treat a psoriasic external Chinese medicinal ointment, it is characterized in that the crude drug weight proportion of described Chinese medicinal ointment: Radix Ginseng 9-11 part, Moschus 1-3 part, Flos Carthami 4-6 part, Calculus Bovis 4-6 part, Borneolum Syntheticum 9-11 part, Herba Menthae 9-11 part, Alumen 4-6 part, Calomelas 0.4-0.8 part, Catechu 4-6 part.

2. treat psoriasic external Chinese medicament ointment preparation for one kind, it is characterized in that the crude drug weight proportion of described Chinese medicinal ointment: Radix Ginseng 9-11 part, Moschus 1-3 part, Flos Carthami 4-6 part, Calculus Bovis 4-6 part, Borneolum Syntheticum 9-11 part, Herba Menthae 9-11 part, Alumen 4-6 part, Calomelas 0.4-0.8 part, Catechu 4-6 part, preparation method is: above nine taste medical materials, get Moschus, Calculus Bovis, Borneolum Syntheticum, Herba Menthae, Alumen, Calomelas, Catechu be ground into fine powder, mix homogeneously respectively; Processed with wine Radix Ginseng, processed with wine Flos Carthami powder are broken into coarse powder, then carry out percolation with 50% ethanol, collect medicinal liquid, reclaim ethanol concentrate drying and are ground into fine powder; By above all fine powders mixing, add after crossing 100 mesh sieves vaseline mixing external-applied ointment.