CN204723468U - A kind of skin wound treatment system for wound debridement, administration oxygen supply - Google Patents

Abstract

This utility model relates to a kind of skin wound treatment system for wound debridement, administration oxygen supply, comprise for covering adsorbate on wound, for generation of negative pressure and collect the liquid collector of liquid, connect the drainage pipe of adsorbate and liquid collector, transfusion bag and be connected the flushing pipe of adsorbate and this transfusion bag, and described transfusion bag in the vertical direction exceeds this adsorbate, oxygen supply device for generation of oxygen, and connecting the oxygen therapy pipeline of adsorbate and oxygen supply device, described drainage pipe, flushing pipe, oxygen therapy pipeline are provided separately.Realize Chinese medicine (compound phellodendron bark liquid) Arthrocentesis and naturopathy combines; play protection wound surface, prevention infection, wound healing effect, and easy to use, reduce dressing change frequency; shorten treatment time, thus reduce Principle of Pain and medical personnel's burden.

Description

A kind of skin wound treatment system for wound debridement, administration oxygen supply

Technical field

This utility model belongs to field of medical device, particularly a kind of skin wound treatment system for wound debridement, administration oxygen supply.

Background technology

For process and the treatment of acute and chronic wounds, mostly the method for bandaging is still adopted tentatively to nurse in early days, form is single, how the clinical process for wound now adopts normal saline flushing separately, sterilization processing, the methods such as dressing covers, Wound-surface negative pressure closed, do not look after each side factor relevant to wound healing in wound, have impact on the healing of wound surface, thus cause become easily infected by antibacterial in course of conveying, also need repeated multiple times cleaning, remove impurity, wound may be made to expand; For infectious Hard agglut wound, often adopt gauze Hydropathic compress medicament to treat, this kind of method, change dressings frequent, tear to produce in pain, the drug of topical application process when changing dressings and hinder normal activity, bring burden to medical personnel and produce misery to patient.

In recent years, the negative pressure wound therapy instrument of clinical employing, builds one in wound location and closes and moistening environment, extract edematous fluid out, improve blood circulation.The successful Application of negative pressure treatment in all kinds of wound makes people see wound surface to cover in early days, the successional advantage of prevention infection and Wound treating.

But also there are some problems:

1. treatment means is single, lack rinse debridement, drug conveying, to Therapeutic Method such as oxygen therapies.

2. drain is insufficient, and especially to many with slough, darker wound surface or wound, not at that time, the negative pressure cecum that negative pressure drainage itself causes, can not make transudate and the complete drain of slough of wound surface local to slough debridement treatment.

3. wound surface is in isolation, and in tissue, negative pressure forming region has the probability increasing anaerobic infection.

4. the clinical efficacy of Appropriate application negative pressure treatment is affirmative, but waits to determine for the optimal treatment parameter of different patient and concrete wound surface.

5. there is potential risk: the safety message in U.S. FDA on November 16th, 2009 is announced negative pressure treatment and caused 6 routine death events.Main cause breaks at negative pressure treatment process medium vessels to cause the hemorrhage Timeliness coverage of failing of rapid, high volume, causes patient's hemorrhagic shock finally dead.

6. lack cure mechanism comprehensively effective medicine with the use of.

Chronic Hard agglut wound is because patient's local organization ischemia, neuropathy, along with disease ulcer, infection, necrosis can occur successively, particularly the ischemia of the peripheral arterial such as shank changes, cause ulcer wound surface oxygenate, nutrition supply obstacle and infected tissue's hypoimmunity and infect uncontrollable and tissue necrosis occurs, finally cause amputation, pathogeny is complicated, and treatment difficulty is large.Chinese medicine external wound healing, dialectically treats, and curative effect is comprehensive, with " heat-clearing and toxic substances removing, putrefaction-removing granulation-promoting, blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain " for main Therapeutic Principle.The mechanism of action of external application Chinese medicine wound healing, mainly by antibacterial, antiinflammatory, enhancing immunity, short more, neuroprotective and reparation, improve infected wound microcirculation and healing environment, comprehensive onset reaches good therapeutic effect.

Chinese medicine is because its comprehensive cure mechanism in the chronic Hard agglut wound for the treatment of, infected wound in recent years, and rational dosage form advantage, is widely used clinically.Compound phellodendron bark liquid is the new surgical Chinese medicine preparation of domestic initiation, according to Traditional Chinese medical theory, preferred successful traditional prescription, is the external good medicine of the ulcer suppurative wounds such as carbuncle, cellulitis, skin infection, trauma infection contamination, fills in the medicine for external use such as sinus tract or external application approach with the sliver that irrigates, soaks.Modern study shows; compound phellodendron bark liquid not only has the effect of antibacterial, infection, wound healing, nervous system protection, and strengthen mononuclear phagocyte phagocytic activity, improve non-specific immunity and alleviate in local inflammation response strength etc. and also there is obvious curative effects.Clinical Practice has shown to have broad-spectrum antibacterial action, can eliminate rapidly wound redness, promotes the elimination of purulent secretion, reduces secretions, accelerates the dry and granulation tissue growth in rotten to the corn face and wound healing.

Utility model content

Therefore this utility model is by a kind of comprehensive therapeutic instrument system, better Chinese medicine external medicinal liquid is transported to affected part, gives full play to the advantage of naturopathy and Drug therapy, promotes wound healing.

This product is a kind of skin wound treatment system for wound debridement, administration oxygen supply, and it comprises vacuum suction-rinse-system, drug-supplying system, oxygen supply system, temperature control system and wound closure systems, and waste collection system, the shortcoming of the existing negative pressure therapeutic instrument of this product improvement and traditional Wound treating, according to physiopathological change in the agglutination of wound surface, set modern science, advanced wound healing theory (negative pressure treatment, close healing, moistening healing, Chinese medicine Mutiple Targets group effect etc.), by each is theoretical, the advantage of technology is carried out integrated, that an advanced integrated utility model is created, realize cflush treatment and naturopathy combine, can effectively play protection wound surface, treatment and prevention traumatic infection, the effect of multiple means wound healing, and carry with easy to use, there is uninterrupted continued treatment, reduce Principle of Pain, the effect of optimal healing environment is provided to wound surface, thus shorten treatment time, reduce hospital day, save heath economics expense, be conducive to generally reducing society, patient, country is relevant expenditure on Wound treating.

For achieving the above object, this utility model adopts following technical scheme:

A kind of skin wound treatment system for wound debridement, administration oxygen supply, comprise control device, the liquid collector of liquid is collected for covering adsorbate on wound, for generation of negative pressure, connect the drainage pipe of adsorbate and liquid collector, transfusion bag and be connected the flushing pipe of adsorbate and this transfusion bag, for generation of the oxygen supply device of oxygen, and connecting the oxygen therapy pipeline of adsorbate and oxygen supply device, described drainage pipe, flushing pipe, oxygen therapy pipeline are provided separately.

Further, described system also comprises temperature control system, disinfection cabinet, movable pulley car.

Further, described adsorbate is the sponge of band side opening pipeline.

Further, the sponge surrounding of described band side opening pipeline is provided with biological permeability pad pasting.

Further, described therapy system is also provided with temperature control storage system.

Further, vacuum range 0mm Hg ~ 200mm Hg of described negative pressure pump, lower negative threshold 0mm Hg ~ 30mm Hg, upper negative threshold 100mm Hg ~ 130mm Hg.

Further, described negative pressure pump provides intermittent negative pressure, and the negative pressure height of applying is interval variation regularly, and negative pressure just can decline after predetermined time interval, through another predetermined time interval negative pressure can again raise.

Further, described peristaltic pump provides and instils and rinse two kinds of functions, and feed fluid velocity interval is 0 ~ 60ml/min.

Further, there is communication link between described peristaltic pump and control device; Control device is outputed signal for cutting off peristaltic pump by communication link, thus interrupts the continuation conveying of drip liquid.

Further, described oxygen supply device is oxygen tank, instrument is arranged the device controlling oxygen flow, and on oxygen cylinder, the inconvenience of valve button regulates during oxygen flow and uses.

Further, in described transfusion bag, flushing liquor or medicinal liquid are housed.

Further, described flushing liquor medicinal liquid is made up of one or more of the crude drug of following percetage by weight: Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Scolopendra, Pheretima, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae, Scorpio, periplaneta americana, Rhizoma Drynariae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Cyathulae, Radix Dipsaci, Flos Carthami, Sanguis Draxonis, Borax.

Further, described flushing liquor and medicinal liquid adopt above-mentioned medical material to extract through volatile oil is drawn, ethanol or ethanol water, and water extraction, after alcohol settling, centrifugal remove impurity, mixing, filtration, clear aqueous solution is made in sterilizing.

Further, described volatile oil makes water miscible volatile oil clathrate compound by HYDROXYPROPYL BETA-CYCLODEXTRIN enclose.

Further, described animal drug extract comprises one or more of extract of Scolopendra, Pheretima, Scorpio.

Further, described medicinal liquid pH value is 4-6

Further, described medicinal liquid is compound phellodendron bark liquid.

The main scope of application of this product: various acute and chronic wound surface, as the wound surface that the acute injuries such as traumatic open wound surface, burn cause, and the difficult healing such as pressure ulcer, diabetic foot, vascular ulcers wound surface.

Treatment concept of the present utility model:

1. oxygen determines epithelization, the maturation of collagen and the key factor of the result such as synthesis, wound contracture.Research finds, pure oxygen mainly concentrates on the enhancing of metabolic activity and raising two aspect of epidermal migration speed to the impact of open wound surface.

2. provide a micro-acid and moist environment to wound surface, wound surface slough can be impelled to come off, stimulate fibroblast proliferation, blood capillary plumule is grown and the object of re-epithelialization process, and then Promotive union, pH is 4-6, can provide a micro-acid and moistening environment for wound surface.

3. the overall process of wound healing is participated in by many cytokines in fact and regulates and controls.Somatomedin has not only participated in the inflammatory reaction of wound surface directly, but also affects a series of biological processes such as the transformation of tissue repair cell cycle.There are some researches show, why prolonged some chronic wounds are does not heal, its main cause is that these wound surface lack inflammatory reaction on the one hand, lack release and the growth stimulation of Endogenous Growth Factors, its tissue repair cell is in again a kind of resting state on the other hand, and on its cell membrane, corresponding growth factor receptors is lowered.Adding of exogenous growth factor, this series of biologic process can be improved.

4. negative pressure treatment wound surface can make the edematous fluid of extravascular space gap be drawn out of rapidly, alleviates microcirculation disturbance, improves supply of blood flow, and its mechanical tension force effect simultaneously can directly stimulate cellular proliferation.In addition, negative pressure treatment maintains the moist environment of wound surface, also has certain antibacterial action.

5. Chinese traditional treatment is divided into and disappears, holds in the palm, mends three methods.Early stage to disappear, heat-clearing and toxic substances removing; Mid-term, eliminating the toxic material out by tonification was held concurrently with removing toxic substances based on holder; Late period based on mend, QI invigorating Tuoli granulation promoting.Simultaneously according to the same use of the many methods of wound surface situation, grasp flexibly.

6. utilize Chinese medicine debridement to treat the Analysis on Mechanism of liquid treatment

Chinese medicine is started with from the etiology and pathogenesis of skin infection, select heat-clearing and toxic substances removing, repercussive is promoted blood circulation, the Chinese medicine of reducing swelling and alleviating pain and putrefaction-removing granulation-promoting, its wound healing rate is higher, by Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Scolopendra, Pheretima, Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Violae, Scorpio, periplaneta americana, Rhizoma Drynariae, Radix Notoginseng, Radix Angelicae Sinensis, Radix Cyathulae, Radix Dipsaci, Flos Carthami, Sanguis Draxonis, the medicine compositions such as Borax, Fructus Forsythiae ester glycoside such as, in prescription contained by Fructus Forsythiae, phillyrins etc. all have very strong antibacterial activity, has a broad antifungal spectrum, to multiple gram positive bacteria, negative bacterium all has inhibitory action, and there is anti-endotoxin effect, in prescription, the Cortex Phellodendri decoct of Cortex Phellodendri, water-leach liquor or alcohol leaching liquid are strong to suppurative bacterium bacteriostasis, especially have stronger fungistatic effect to positive cocci such as staphylococcus aureus, micrococcus scarlatinae, epidermis coccuses, in prescription, Flos Lonicerae has the functions such as antibacterial, antiinflammatory, enhancing immunity, in prescription, Herba Taraxaci has broad-spectrum antibacterial effect, all has inhibitory action in various degree to multiple pathogenic microorganisms such as gram positive bacteria, gram negative bacteria, fungus, spirillums, Scolopendra pharmacological action is extensive, has antiinflammatory, analgesia, antibacterial, defying age, vascular protection effect.The product of bitter cold in side, effect of many tools heat-clearing and toxic substances removing, has the effect of resisting pathogenic microbes, can promote the healing of wound.

Outstanding characteristic of the present utility model is: the various healings in conjunction with wound surface theoretical (negative pressure treatment, close healing, moistening healing, treatment by Chinese herbs etc.) also improve the shortcoming of existing negative pressure therapeutic instrument and traditional Wound treating and utility model making; realize Chinese medicine (compound phellodendron bark liquid) Arthrocentesis and naturopathy combines; play protection wound surface, prevention infection, wound healing effect; and it is easy to use; reduce dressing change frequency; shorten treatment time, thus reduce Principle of Pain and medical personnel's burden.

(1) integrate the Wound treating system of flushing, treatment, liquid collecting, it can prevent traumatic infection and promote wound healing.

(2) compound phellodendron bark liquid can be built in conjunction with common dressing and close and moistening healing environment, and pH 4 ~ 6, also can be the Curing circumstance that wound provides micro-acid, more meet Wound healing and bone regeneration theory.

(3) temperature control.When making medicine arrive wound location, therapeutic effect is best, is more suitable for the healing of wound.

(4) oxygen supply.Prevent anaerobic infection on the one hand, on the other hand for angiogenesis provides oxygen.

(5) drug or be beneficial to the nutrient of wound healing.

(6) real-time collecting liquid, is convenient to inspection, carries out next step treatment.

(7) using method of compound phellodendron bark liquid is optimized, more convenient, more save, the use of compound phellodendron bark liquid can be promoted to a certain extent.

The each module declaration of this utility model system and requirement

Drainage system selects membrane pump to provide negative pressure, require that its range of negative pressure that produces is 0mm Hg ~ 200mm Hg, membrane pump can input complicated program in order to accurately to control negative pressure drainage process by means of suitable input equipment such as button, keyboard, touch screen or computer interface, and can intermittent negative pressure be produced, namely negative pressure height is interval variation regularly, negative pressure just can decline after predetermined time interval, through another predetermined time interval negative pressure can again raise.

Drug-supplying system preferably uses peristaltic pump, and selected peristaltic pump can realize drug irrigation and the two kinds of functions that instil by control device, requires peristaltic pump flow rates 0 ~ 60ml/min.

Oxygen supply system selects replaceable medical oxygen tank, and on instrument, arrange the device controlling oxygen flow, accurately can control oxygen gas flow rate.

Temperature control system, require the medicine reaching wound site can be made to be rapidly heated to required optimum temperature by adjusting device, temperature-control range is at 0 DEG C ~ 60 DEG C.

Accompanying drawing explanation

Fig. 1 is this apparatus structure schematic diagram, wherein: 1-1. is with the sponge of side opening pipeline; The biological permeability pad pasting of 1-2.; 1-3. liquid-collecting bottle; 1-4. negative pressure pump; 1-5. control system; 1-6. oxygen tank; 1-7. stores medicine bottle; 1-8. temperature control element; 1-9. peristaltic pump;

Fig. 2 is the axonometric chart of this device, wherein, and 1. biological permeability pad pasting; 2. be with the sponge of side opening pipeline; 3. peristaltic pump medicine liquid outlet; 4. peristaltic pump medicinal liquid entrance; 5. store medicine bottle; 6. oxygen outlet; 7. temperature control registration; 8. temperature control regulates button; 9. oxygen gas flow rate registration; 10. oxygen regulates button; 11. vacuum registrations; 12. vacuum adjustment knob; 13. peristaltic pump rotating speeds (medicinal liquid flow velocity) registration; 14. flow rate regulation buttons; 15. oxygen intakes; 16. vacuum connection port; 17. oxygen channels; 18. medicinal liquid connecting pipes; 19. drainage pipes; 20. bonding in vacuum pipelines; 21. liquid-collecting bottles; 22. I type joints; 23.Y type joint; 24. peristaltic pumps.

Fig. 3 Clinical practice scheme

Concrete embodiment

Embodiment 1

A kind of skin wound treatment system (as shown in Figure 1) for wound debridement, administration oxygen supply, comprise for covering the sponge 1 with side opening pipeline on wound, the surrounding of described sponge is also provided with biological permeability pad pasting 2, the liquid-collecting bottle 3 of liquid is collected for generation of negative pressure, connect the drainage pipe 16 of spongy body and liquid collector, store medicine bottle 7 and be connected the flushing pipe of adsorbate and this storage medicine bottle, and the described oxygen tank for generation of oxygen, and connecting the oxygen therapy pipeline of sponge and oxygen tank, described drainage pipe, flushing pipe, oxygen therapy pipeline are provided separately;

Described system also comprises:

Negative pressure pump

1. vacuum suction is provided; 2. membrane pump is selected; 3. vacuum range 0mm Hg ~ 200mm Hg, lower negative threshold 0mmHg ~ 30mm Hg, upper negative threshold 100mm Hg ~ 130mm Hg; 4. complicated program can be inputted in order to control negative pressure treatment in time by means of suitable input equipment such as button, keyboard, touch screen or computer interface; 5. intermittence negative pressure, require that the negative pressure height that applies is interval variation regularly, negative pressure just can decline after predetermined time interval, through another predetermined time interval negative pressure can again raise.Such as, after setting vacuum 150mm Hg, it is made to attract 10min to rest 5min; 6. negative pressure treatment process can accurately be controlled by control device.

Peristaltic pump

1. provide and instil and rinse two kinds of functions; 2. feed fluid velocity interval is 0 ~ 60ml/min.3. there is communication link between peristaltic pump and control device; 4. control device is outputed signal for cutting off peristaltic pump by communication link, thus interrupts the continuation conveying of drip liquid.

Oxygen tank

1. select replaceable oxygen tank to be 2. provided with the device controlling oxygen flow, on oxygen cylinder, the inconvenience of valve button regulates during oxygen flow and uses.

Using method

A. wound closure: the sponge 1 of band side opening pipeline is placed on the wound needing treatment.Sponge directly and wound surface contact.Sponge 1 is covered by biological permeability pad pasting 2 with the part of next-door neighbour's wound, therefore between biological permeability pad pasting 2 and wound bed, defines wound area.Wherein biological permeability pad pasting 2 is pasted onto on skin intact around patient wound, and encloses wound area airtightly.

B. rinse: add flushing liquor in storage medicine bottle 7, open peristaltic pump 9, make flushing liquor enter wound location fast, wound location surface clean is clean, close peristaltic pump 9, open negative pressure pump 4, flushing liquor is exhausted, regulates vacuum magnitude by control system 5, the impurity of wound location depths is exhausted.

C. to instil treatment: close negative pressure pump 4, add herb liquid (or compound phellodendron bark liquid) in storage medicine bottle 7, open peristaltic pump 9, regulate flow velocity, make herb liquid (or compound phellodendron bark liquid) slowly instill wound location, carry out Drug therapy, each about 0.5 ~ 1h, every day 2 times.

D. negative pressure treatment: after treatment of instiling, close peristaltic pump 9, open negative pressure pump 4, by the sucking-off of wound location compound phellodendron bark liquid, after exhaustion, regulate vacuum magnitude by control system 5, negative pressure treatment is carried out to wound location.

Described negative pressure pump provides intermittent negative pressure, and the negative pressure height of applying is interval variation regularly, and negative pressure just can decline after predetermined time interval, through another predetermined time interval negative pressure again to raise.

Drug component:

Described debridement treatment medicinal liquid for the drug component corresponding to different therapeutic purposes as following table:

When therapeutic purposes are one or more combinations of above-mentioned therapeutic purposes, drug component is corresponding combination.

For by the herb liquid prescription I of this utility model therapy system: (the preferred pharmaceutical formulation of drug component): Cortex Phellodendri 40 ± 8 parts, Flos Lonicerae 40 ± 8 parts, Fructus Forsythiae 80 ± 16 parts, Herba Taraxaci 40 ± 8 parts, Radix Salviae Miltiorrhizae 30 ± 6 parts, Scolopendra 2.5 ± 0.5 parts, Pheretima 20 ± 4 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ± 2 parts, Herba Violae 10 ± 2 parts, Scorpio 2.5 ± 0.5 parts, Rhizoma Drynariae 15 ± 3 parts, Radix Notoginseng 10 ± 2 parts, Radix Angelicae Sinensis 10 ± 2 parts, Radix Cyathulae 25 ± 5 parts, Radix Dipsaci 20 ± 4 parts, 5 ± 1 parts, Flos Carthami, Sanguis Draxonis 20 ± 4 parts, Borax 5 ± 1 parts.

Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding in side, detumescence and promoting granulation; Cortex Phellodendri, Radix Scutellariae, Rhizoma Coptidis heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Flos Lonicerae, Herba Violae, Fructus Forsythiae clearing heat, releasing toxin, removing swelling; Modern pharmacological research shows, the antipyretic and antidotal type medical instruments such as Flos Lonicerae, Herba Violae, Fructus Forsythiae have antibacterial, antiinflammatory, have facilitation to the immunity of body; Chinese Angelica blood replonishing tonifying YIN, regulating liver-QI of invigorating blood circulation; Radix Salviae Miltiorrhizae, Radix Notoginseng, Rhizoma Drynariae, Flos Carthami promoting blood circulation and stopping pain, blood stasis dispelling eliminating carbuncle; Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Polyporus promoting diuresis to eliminate damp pathogen; Pheretima, Radix Cyathulae removing blood stasis dredging collateral; Scolopendra, Scorpio endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, dispersing pathogen accumulation; Sanguis Draxonis, Radix Dipsaci are invigorated blood circulation analgesic therapy, removing stasis to stop bleeding, promoting tissue regeneration and ulcer healing; Borax heat-clearing and toxic substances removing, detumescence; All medicines share, and play anti-inflammation, promote wound surface microcirculation, improve wound surface environment, improve immunity, the generation of the growth promoting effects factor, thus the healing being conducive to wound surface.

Debridement treatment medicinal liquid is prepared as follows after one or more prescriptions of drug component:

(1) volatile oil is drawn: adopt the water vapour water proof way of distillation to extract volatile oil containing volatile oil medical material, gained volatile oil with 3-5 times amount HP-β-CD bag and.

(2) ethanol extraction: get prescription Chinese crude drug, add 70%-95% alcohol reflux 2-3 time of 6 times amount volumes, each 1h, extracting solution is evaporated in right amount, adds distilled water, cold preservation, leaves standstill 24h; Add 1%-10% HP-β-CD and carry out hydrotropy, filter, concentrated, obtain alcohol extract;

(3) water extraction alcohol settling purification: medical material after alcohol extraction, add water reflux, extract, 2-3 time of 6 times amount volumes, each 1h, extracting solution is evaporated in right amount, adds distilled water and makes concentration of alcohol be 70%, cold preservation, leaves standstill 24h; Filter, be evaporated to without alcohol taste, obtain Aqueous extracts;

(4) volatile oil clathrate compound, alcohol extract are mixed homogeneously with Aqueous extracts, add appropriate distilled water, cold preservation, filter, to obtain final product.

(5) fill, sterilizing.

Embodiment 2

Medicinal liquid preparation method

(1) prescription II: Fructus Forsythiae 80 weight portion, Cortex Phellodendri 40 weight portion, Flos Lonicerae 40 weight portion, Herba Taraxaci 40 weight portion, Scolopendra 2.4 weight portion.

(2) preparation method

Prepared by volatile oil clathrate compound: adopt the water vapour water proof way of distillation to extract volatile oil containing volatile oil medical material, gained volatile oil with 3 times amount HP-β-CD bags with.

Prepared by alcohol extract: get not containing the medical material of volatile oil in the medical material and prescription extracting volatile oil, the mass concentration adding 6 times amount volumes is 15% alcohol reflux 3 times, each 1h, and extracting solution is evaporated in right amount, adds appropriate distilled water, cold preservation, leaves standstill 24h; Filter, concentrated, obtain alcohol extract;

Prepared by Aqueous extracts: medical material after alcohol extraction, and add the water reflux, extract, 2 times of 6 times amount volumes, each 1h, extracting solution is evaporated in right amount, adds distilled water and makes ethanol mass concentration be 50%, cold preservation, standing 24h; Filter, be evaporated to without alcohol taste, obtain Aqueous extracts;

Volatile oil clathrate compound, alcohol extract are mixed homogeneously with Aqueous extracts, add appropriate distilled water, cold preservation, filter, fill, sterilizing, obtain medicinal liquid.

Embodiment 3

Using prescription I as treatment medicinal liquid, carry out clinical observation on the therapeutic effect.

1. clinical observation on the therapeutic effect

1.1 decubital ulcer

1.1.1 inclusion criteria

(1) decubital ulcer occurred before being admitted to hospital, wound surface meets III phase or IV phase of American National pressure ulcer consultative committee (NPUAP) staging system by stages, and is the huge ulcer of single-shot, diameter >5cm;

Age <70 year;

Wound surface purulence is oozed out, around have red, swollen, bitterly, the local inflammation such as heat shows;

Without severe total systematic complication.

1.1.2 curative effect determinate standard

Recovery from illness: treatment 30d wound surface heals completely, grows new granulation tissue;

Effective: wound surface obviously reduces, ruddy, there is most of new granulation tissue;

Effective: wound surface reduces, part wound surface is ruddy, inflammatory exudate reduces;

Invalid: after treatment, wound surface is front without significant change with treatment.

Total effective rate=cure rate+obvious effective rate+effective percentage

1.1.3 Therapeutic Method

Carry out treating (using method is with embodiment 1) with the medicine partner treatment system of prescription I after treatment group debridement, after matched group debridement, medicine infiltrates gauze soak.Two groups of equal timing turning overs, and strengthen nutritional support treatment.

1.1.4 result

(1) two group of case basic condition compares

Related index observed result after (2) two groups of wounds treatments

(3) two groups of Patient Global's efficacy evaluations compare

Group

Recovery from illness

Effective

Effectively

Invalid

Total effective rate

Treatment group	32(89％)	2(5.6％)	1(2.8)	1(2.8)	97％
						Matched group	28(78％)	2(5.6％)	1(2.8)	5(14)	86％

1.2 diabetic foot

1.2.1 inclusion criteria

Western medicine diagnose standard: " diabetic foot (acromelic gangrene) inspection method and the diagnostic criteria " of formulating with reference to Chinese Medical Association in 2000 the 2nd diabetic foot meeting.

(1) there is clear and definite diabetic history;

(2) foot has the wound surface such as ulcer or gangrene, and clinical manifestation is local erosion, ulcer, necrosis, wound surface is prolonged does not heal;

(3) the age is between 18-75 year, not sex-limited, wound area≤10cm ²actute infection patient;

(4) glycemic control is good, wherein fasting glucose≤7mmol/L, post-prandial glycemia≤10mmol/L person;

Standards of Chinese Medical Syndrome Differentiation:

With reference to differentiation of symptoms and signs for classification of syndrome standard and " the new Chinese medicine guideline of clinical investigations " of necrosis in " People's Republic of China's traditional Chinese medicine industry standard-Chinese medical disease Standardization of diagnosis and curative effect ".

Damp-heat accumulation type

Primary symptom: onset is comparatively anxious, suffer from sufficient ulceration and rot, a large amount of stiff purulent secretion, gas is dirty, and wound granulation organizes red fresh aquatic food profit or slightly secretly stale, and local color of the leather flushing or purplish red, swelling is obvious.

Secondary disease: it is obvious to suffer from chronic foot pain, and wound Zhou Zhuore, likes cool, thirst and liking drink, large dry stool, yellow urine, red tongue, yellow and greasy fur, slippery and rapid pulse or moisten number.Primary symptom all possesses, secondary disease at least 2, with reference to tongue arteries and veins, namely diagnosable.

1.2.2 TCM syndrome evaluation standard

In ulcer primary symptom open sore part area, the open sore part degree of depth, all rednesses of skin ulcer, granulation situation, pus situation, according to disease Standardization of diagnosis and curative effect, be divided into 4 grades, be designated as 0 point, 2 points, 4 points, 6 points respectively; In ulcer time disease pain, thirsty two, be divided into 4 grades, be designated as 0 point, 1 point, 2 points, 3 points respectively; Secondary disease skin ulcer Zhou Zhuore, large dry stool, yellow urine remember 0 point and 1 point respectively.Therapeutic effect of syndrome score summation scoring=primary symptom+secondary disease.

1.2.3 curative effect determinate standard

" the surgery of Chinese medicine disease Standardization of diagnosis and curative effect " promulgated with reference to nineteen ninety-five State Administration of Traditional Chinese Medicine is formulated

(1) fully recover: wound healing or substantially heal, syndrome integral reduces between 90%-100% (containing 90%).

(2) effective: wound surface area reduces >50%, and granulation tissue is light red, without pus, the red and swollen obviously disappearance of wound week, pain alleviates substantially, and syndrome integral reduces between 60%-90% (containing 60%).

(3) effective: wound surface area is reduced into 20%-50% (containing 50%), and granulation tissue is scarlet, can have a small amount of pus, wound week is slightly red and swollen, and syndrome integral reduces between 30%-60% (containing 30%).

(4) invalid: wound surface area reduces <20% or even increases the weight of without significant change, syndrome integral minimizing is less than 30%.

Note: syndrome integral computing formula: [after (before treatment the rear integration of integration-treatment)/treatment integration] × 100%

Total effective rate=cure rate+obvious effective rate+effective percentage

1.2.4 therapeutic scheme

(1) clean wound surface: according to the concrete condition of wound surface, if any the tissue of obviously corrupt necrosis, should remove in time, to nibble wound excision, and with normal saline flushing wound surface and pus, creates week iodophor disinfection.

(2) dressing change method: treatment group 98 example, adopts medicine partner treatment system to treat; Matched group 80 example, using medicine to infiltrate gauze soak and treat, 28 days is a course for the treatment of.

1.2.5 result

(1) two group of case basic condition compares

(2) two groups of patient's different time ulcer areas compare

Group	Before treatment	7d	14d	21d	28d
						Treatment group	7.2±2.41	6.88±2.21	5.59±2.14	3.97±2.04	2.23±2.24
Matched group	7.5±2.58	7.75±2.58	6.99±2.21	4.61±2.69	3.82±2.16

(3) two groups of Patient Global's efficacy evaluations compare

Group	Recovery from illness	Effective	Effectively	Invalid	Total effective rate
						Treatment group	29(30％)	15(15％)	46(47％)	8(8％)	92％
Matched group	17(17％)	11(11％)	55(56％)	15(15％)	85％

Embodiment 4

For a skin wound treatment system for wound debridement, administration oxygen supply, structure is identical with embodiment 1, and difference is that native system adopts prescription II as treatment medicinal liquid.

Embodiment 5

For a skin wound treatment system for wound debridement, administration oxygen supply, structure is identical with embodiment 1, and difference is that native system is also provided with temperature control storage system, institute's controlling temperature scope 0 ~ 60 DEG C.

Embodiment 6

For a skin wound treatment system for wound debridement, administration oxygen supply, structure is identical with embodiment 1, and difference is that native system is also provided with disinfection cabinet.

Embodiment 7

For a skin wound treatment system for wound debridement, administration oxygen supply, structure is identical with embodiment 1, and difference is that native system is also provided with movable pulley car.

Embodiment 8

For a skin wound treatment system for wound debridement, administration oxygen supply, structure is identical with embodiment 1, and difference is that native system is also provided with temperature control storage system, disinfection cabinet, movable pulley car.

Embodiment 9

For a treatment medicinal liquid for the skin wound treatment system of wound debridement, administration oxygen supply, formula is as follows: Cortex Phellodendri 40 parts, Flos Lonicerae 40 parts, Fructus Forsythiae 80 parts, Herba Taraxaci 40 parts, Radix Salviae Miltiorrhizae 30 parts, Scolopendra 2.5 parts, Pheretima 20 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Herba Violae 10 parts, Rhizoma Drynariae 15 parts, Radix Notoginseng 10 parts, Radix Angelicae Sinensis 10 parts, Radix Cyathulae 25 parts, Radix Dipsaci 20 parts, 5 parts, Flos Carthami, Sanguis Draxonis 20 parts, Borax 5 parts.

Its preparation and application is with embodiment 1.

Embodiment 10

For a treatment medicinal liquid for the skin wound treatment system of wound debridement, administration oxygen supply, formula is as follows: Cortex Phellodendri 32 parts, Flos Lonicerae 32 parts, Fructus Forsythiae 64 parts, Herba Taraxaci 32 parts, Radix Salviae Miltiorrhizae 24 parts, Scolopendra 2 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Herba Violae 8 parts, Rhizoma Drynariae 12 parts, Radix Notoginseng 8 parts, Radix Angelicae Sinensis 8 parts, Radix Cyathulae 20 parts, 4 parts, Flos Carthami, Sanguis Draxonis 16 parts, Borax 4 parts.

Its preparation and application is with embodiment 1.

Embodiment 11

For a treatment medicinal liquid for the skin wound treatment system of wound debridement, administration oxygen supply, formula is as follows:: Cortex Phellodendri 48 parts, Flos Lonicerae 48 parts, Fructus Forsythiae 96 parts, Herba Taraxaci 48 parts, Radix Salviae Miltiorrhizae 36 parts, Pheretima 24 parts, Herba Violae 12 parts, Rhizoma Drynariae 18 parts, Radix Notoginseng 12 parts, Radix Angelicae Sinensis 12 parts, Radix Dipsaci 24 parts, 6 parts, Flos Carthami, Sanguis Draxonis 24 parts, Borax 6 parts.

Its preparation and application is with embodiment 1.

By reference to the accompanying drawings detailed description of the invention of the present utility model is described although above-mentioned; but the restriction not to this utility model protection domain; one of ordinary skill in the art should be understood that; on the basis of the technical solution of the utility model, those skilled in the art do not need to pay various amendment or distortion that creative work can make still within protection domain of the present utility model.

Claims (9)

1. the skin wound treatment system for wound debridement, administration oxygen supply, it is characterized in that, comprise control device, for cover adsorbate on wound, for generation of negative pressure negative pressure pump, collect the liquid collector of liquid, connect the drainage pipe of adsorbate and liquid collector, transfusion bag and be connected the flushing pipe of adsorbate and this transfusion bag, the peristaltic pump be connected with described flushing pipe, for generation of the oxygen supply device of oxygen, and connecting the oxygen therapy pipeline of adsorbate and oxygen supply device, described drainage pipe, flushing pipe, oxygen therapy pipeline are provided separately.

2. therapy system as claimed in claim 1, it is characterized in that, described system also comprises temperature control system, disinfection cabinet, movable pulley car.

3. therapy system as claimed in claim 1, is characterized in that, described adsorbate is the sponge of band side opening pipeline.

4. therapy system as claimed in claim 3, it is characterized in that, the sponge surrounding of described band side opening pipeline is provided with biological permeability pad pasting.

5. therapy system as claimed in claim 1, is characterized in that, vacuum range 0mm Hg ~ 200mm Hg of described negative pressure pump, lower negative threshold 0mm Hg ~ 30mm Hg, upper negative threshold 100mm Hg ~ 130mm Hg.

6. therapy system as claimed in claim 5, it is characterized in that, described negative pressure pump provides intermittent negative pressure, and the negative pressure height of applying is interval variation regularly, negative pressure just can decline after predetermined time interval, through another predetermined time interval negative pressure can again raise.

7. therapy system as claimed in claim 1, is characterized in that, described peristaltic pump provides and instils and rinse two kinds of functions, and feed fluid velocity interval is 0 ~ 60ml/min.

8. therapy system as claimed in claim 7, is characterized in that there is communication link between described peristaltic pump and control device; Control device is outputed signal for cutting off peristaltic pump by communication link, thus interrupts the continuation conveying of drip liquid.

9. therapy system as claimed in claim 1, it is characterized in that, described oxygen supply device is oxygen tank, instrument is arranged the device controlling oxygen flow, and on oxygen cylinder, the inconvenience of valve button regulates during oxygen flow and uses.