CN1057218C - Chinese medicine preparation for sore, ulcer and infection caused by external wound and preparation method - Google Patents
Chinese medicine preparation for sore, ulcer and infection caused by external wound and preparation method Download PDFInfo
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- CN1057218C CN1057218C CN96106739A CN96106739A CN1057218C CN 1057218 C CN1057218 C CN 1057218C CN 96106739 A CN96106739 A CN 96106739A CN 96106739 A CN96106739 A CN 96106739A CN 1057218 C CN1057218 C CN 1057218C
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 17
- 208000025865 Ulcer Diseases 0.000 title abstract description 18
- 231100000397 ulcer Toxicity 0.000 title abstract description 15
- 208000027418 Wounds and injury Diseases 0.000 title abstract description 7
- 241000131808 Scolopendra Species 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
- 206010040872 skin infection Diseases 0.000 claims description 16
- 238000011109 contamination Methods 0.000 claims description 13
- 208000014674 injury Diseases 0.000 claims description 12
- 230000008733 trauma Effects 0.000 claims description 12
- 241000628997 Flos Species 0.000 claims description 7
- 238000004321 preservation Methods 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 21
- 210000004369 blood Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 201000010099 disease Diseases 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 9
- 230000008961 swelling Effects 0.000 abstract description 7
- 206010052428 Wound Diseases 0.000 abstract description 5
- 238000000034 method Methods 0.000 abstract description 5
- 230000001737 promoting effect Effects 0.000 abstract description 5
- 206010031252 Osteomyelitis Diseases 0.000 abstract description 3
- 206010046914 Vaginal infection Diseases 0.000 abstract description 3
- 201000008100 Vaginitis Diseases 0.000 abstract description 3
- 230000017423 tissue regeneration Effects 0.000 abstract description 3
- 239000003053 toxin Substances 0.000 abstract description 3
- 231100000765 toxin Toxicity 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract 2
- 230000002588 toxic effect Effects 0.000 abstract 2
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 241000245665 Taraxacum Species 0.000 abstract 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000012869 ethanol precipitation Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000614 poison Toxicity 0.000 description 9
- 208000033809 Suppuration Diseases 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 7
- 230000035876 healing Effects 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 206010040943 Skin Ulcer Diseases 0.000 description 4
- 210000001367 artery Anatomy 0.000 description 4
- 235000013372 meat Nutrition 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
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- 231100000019 skin ulcer Toxicity 0.000 description 4
- 210000002105 tongue Anatomy 0.000 description 4
- 210000002700 urine Anatomy 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 206010007247 Carbuncle Diseases 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000036269 ulceration Effects 0.000 description 3
- 206010056377 Bone tuberculosis Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
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- 230000000844 anti-bacterial effect Effects 0.000 description 2
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- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
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- 241000590428 Panacea Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010061926 Purulence Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- CIKWKGFPFXJVGW-UHFFFAOYSA-N ethacridine Chemical compound C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 CIKWKGFPFXJVGW-UHFFFAOYSA-N 0.000 description 1
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- 238000002156 mixing Methods 0.000 description 1
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- 238000005303 weighing Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a Chinese medicine preparation for treating sore, ulcer and infection caused by external wound. The Chinese medicine preparation contains phellodendron bark, dandelion, honeysuckle flower, forsythia fruit and scolopendra, and has the efficiency for clearing away heat and toxic material, eliminating the swelling, stopping toxin and removing blood stasis for promoting tissue regeneration. The Chinese medicine preparation can be used for treating diseases, such as sore, ulcer, infection caused by external wound, osteomyelitis, vaginitis, etc. The Chinese medicine preparation is easily absorbed, and has no toxic or side effect. The present invention has the advantages that the preparing process adopts a water decoction and ethanol precipitation method which is simple and practical, the medicinal herb resources are rich and cheap, the cost is low, and the efficiency is high.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of Chinese medicine preparation that is used for the treatment of skin infection and trauma infection contamination and preparation method thereof.
For a long time, be vast medical research worker's emphasis problem for treatment skin infection and trauma infection contamination always.Shortcomings such as the existing medicine ubiquity that is used for the treatment of this class disease and taken effect slowly, and curative effect is low, and healing time is long.
" Yizong Jinjian) " day: " carbuncle and cellulitis being originally caused by fire toxin, meridians intercept QI and blood and coagulate ", " five gas are crossed the utmost point, all can heat-transformation light a fire ".The disease that is of skin infection more than has been described, how accumulate due to the skin by fire-toxin, the QI and blood harmony stagnates, meridians intercept, the corruption of intenseness of heat meat forms, and the corruption of intenseness of heat meat, meat rottenly become pus, cut behind the ulceration or trauma infection contamination, its cause of disease is nothing more than " heat " and " fire ", belong to positive disease, heat symptom-complex, in the pathology evolution process, be unable to do without " stasis of blood " word.
The Chinese medicine preparation that the purpose of this invention is to provide a kind of heat-clearing and toxic substances removing, promoting tissue regeneration by removing blood stasis.
Another object of the present invention provides a kind of preparation method of above-mentioned Chinese medicine preparation.
The Chinese medicine preparation that is used for the treatment of skin infection and trauma infection contamination of the present invention contains Cortex Phellodendri, Herba Taraxaci, Flos Lonicerae, Fructus Forsythiae and Scolopendra, wherein the parts by weight proportioning of various compositions is as follows: Cortex Phellodendri 30-60 part, Herba Taraxaci 30-60 part, Flos Lonicerae 40-80 part, Fructus Forsythiae 60-120 part, Scolopendra 1.6-4.8 part.
The Chinese medicine preparation that is used for the treatment of skin infection and trauma infection contamination of the present invention adopts is called 12 Fructus Forsythiaes through persons particularly liable to develop skin infection's panacea by ancient Chinese medicine doctor, have heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, the effect of the nuclear evacuation of pus liquid that reduces phlegm, with removing waste heat in the infections fire from go out, wet in the dry infections and Cortex Phellodendri that pus subtracts certainly is combined into monarch drug; The malicious skin ulcer key medicine Flos Lonicerae of controlling that looses to subside a swelling is a ministerial drug; The Herba Taraxaci of examining, specially treating malicious acute mastitis with heat-transformation poison, detumescence is an adjuvant drug, is used for strengthening the merit of its removing toxic substances and promoting subsidence of swelling, dissipating blood stasis evacuation of pus; Scolopendra with merit poison eliminating stagnation, removing obstruction inchannels to removing blood stasis is a messenger drug, monarch, minister, help, make all medicines to share, make Chinese medicine preparation of the present invention have the special effect of removing toxic substances and promoting subsidence of swelling, stasis-dispelling and pain-killing, putrefaction-removing granulation-promoting, the evacuation of pus of reducing phlegm, can make that patient poison removing the necrotic tissue takes off, passages through which vital energy circulates mediation, abundant, the new meat of QI and blood be spontaneous.
Below by observing case 425 examples, wherein adopt the treatment of Chinese medicine preparation of the present invention to organize 305 examples, adopt matched group 120 examples of existing commercially available medicament, the clinical effectiveness of Chinese medicine preparation of the present invention is described.
According to Principle of Statistics, under the prerequisite of treatment group and matched group patient's sex there was no significant difference, patient age there was no significant difference, under two groups of patient's Western medicine diagnose there was no significant differences, course of disease there was no significant difference, tcm symptom there was no significant difference, sign there was no significant difference, skin ulcer area and ulcer degree of depth there was no significant difference, state of an illness there was no significant difference and physico-chemical examination there was no significant difference, illustrate that two groups of patients have comparability.
During contrast therapy, the Therapeutic Method of treatment group is: the sliver that directly will be soaked with Chinese medicine preparation of the present invention spreads in the infected wound outward, or in the abscess of ulceration, if ulcer is darker, the aseptic sebific duct of available diameter 0.5～1.0cm, insert the ulcer bottom, extract Chinese medicine preparation flushing of the present invention with syringe, more than all once a day.The Therapeutic Method of another matched group is: the rehabilitation of producing with Kunming rehabilitation pharmaceutical factory newly directly spreads on the skin ulcer face or makes sliver and fill in the ulcer or the pipe flushing down of darker ulcer inadequate drainage, once a day.
In the therapeutic process, wound surface 2cm
2In, ulcer degree of depth 1cm was a course of treatment with interior person with 10 days; Wound surface 2cm
2More than, the ulcer degree of depth surpasses 1cm person, is a course of treatment with 20 days.
Judge that the observed project of therapeutic outcome has:
1. clinical symptoms and disease are waited: pain degree and healing state, dysfunction have not and recovery situation, traditional Chinese medical science disease such as thirsty, big dry stool, yellowish urine, heating, tongue, arteries and veins etc.
2. sign: skin ulcer face size and healing state, the ulcer degree of depth and recovery situation, redness has that it's too late degree, granulation tissue situation, secretions character and amount, pus color, pus amount what and pus flavor.
3. physico-chemical examination: total white blood cells and classification, urine is routine, antibacterial culturing, liver, renal function, Chest X-rays etc. just.
Through series of observation and detection, contrast therapy result is as follows:
Two groups of dark ulcer healing natural law are relatively as table 1
The dark ulcer healing natural law of table 1 liang group relatively group mean depth cm ((X ± SD) treatment group 2.24 ± 2.46 10.17 ± 4.02 matched group 1.72 ± 0.58 14.19 ± 3.38 liang group symptom curative effect is relatively as table 2 for the healing natural law of X ± SD)
Table 2 liang group symptom curative effect relatively
Treatment group matched group symptom p value
Treatment back cure rate before the cure rate treatment of treatment back before the treatment
(example), (example), (%), (example), (example), just (%) 77 7 90.91 25 7 72 p＜0.01 liang of group sign curative effect is done relatively such as table 3 in red and swollen 284 19 93.30 111 49 55.86 p in pain 290 7 97.58 115 29 74.78 p＜0.01＜0.01 dysfunction, 126 5 96.03 49 12 75.51 p＜0.01 heating thirsty 81 4 95.06 28 5 82.14 p in 119 4 96.64 43 11 74.42 p＜0.01＜yellow 102 4 96.08 26 5 80.77 p of 0.01 urine＜0.01
Table 3 liang group sign curative effect relatively
Treatment group matched group symptom p value
Treatment back cure rate before the cure rate treatment of treatment back before the treatment
(example), (example), (%), (example), (example), (%) compare such as table 4 before and after red and swollen 284 19 93.30 111 47 57.66 p＜0.01 granulation oedema, 155 6 96.13 53 19 64.15 p＜not bright 215 14 93.49 80 34 57.5 p of 0.01 granulation＜0.01 purulent secretion, 236 3 98.73 88 24 72.72 p＜0.01 slurry sexual secretion, 73 5 93.15 31 7 77.42 p＜smelly 39 2 94.87 13 5 61.54 p of 0.01 purulence＜0.01 liang of group tongue arteries and veins curative effect
Compare before and after the table 4 liang group arteries and veins treatment
144 51 147 119 groups of normalization rates of constant, the 95.36 92.27 97.35 95.20 convection potential precedents several 55 33 57 51 of becoming a full member after the thin yellow arteries and veins number treatment precedent several 151 55 151 125 of the yellow thick coating of red tongue body tongue is treated are become a full member 76.36 66.66 84.21 76.47 liang of groups of 42 22 48 39 groups of normalization rates of constant Bacteria Culture situation relatively such as table 5 after shining and treating
Table 5 liang group antibacterial culturing situation relatively
The total routine number of other group of staphylococcus aureus e coli bacillus pyocyaneus
Treat before treating to treat before the back is treated to treat before the back is treated and treat the back treatment before the back is treated and organize 114 43 0 53 1 14 120 matched groups, 47 15 6 20 12 8410 liang of groups state of an illness (severe) and change relatively as table 6
The relation of the table 6 liang group state of an illness and curative effect
The severe group
Recovery from illness produce effects enabledisable worsens the obvious effective rate treatment and organizes 68 10 550 88.63% matched groups 614 15 0 26.92%
More than each the table the data of respectively organizing learn processing by statistics, p illustrates that all less than 0.01 correction data has significant difference.Wherein X is a meansigma methods, and SD is a deviation.
Two groups of total effectses are relatively as table 7
Table 7 liang group total effects relatively group recovery from illness produce effects enabledisable worsens total effective rate treatment group example 258 25 15 70 97.70%
% 84.59 8.19 4.91 2.29 matched group examples 54 20 20 26 0 78.33%
％ 45 16.61 16.61 21.61
Two groups of above total effects comparative results, learn by statistics and handle p＜0.01, illustrate that two groups of total effectses have significant difference, promptly adopt the total effective rate of treatment group of Chinese medicine preparation of the present invention and obvious effective rate, cure rate all apparently higher than the matched group that adopts " rehabilitation is new ".
By above 425 routine YANG syndrome skin infection and trauma infection contamination patient clinical observation result are shown, Chinese medicine preparation treatment skin infection of the present invention and trauma infection contamination determined curative effect, total effective rate 97.7%, obvious effective rate 92.78%, cure rate 84.59%, easy to use, the congestion and swelling pain around the skin infection,, edema not bright to granulation and secretions all there are better curative effect.The heating that may occur skin infection in addition, thirsty, simultaneous phenomenons such as yellowish urine is red, constipation with dry stool also all can be along with the good of skin infection then disappear.And in clinical trial, all case is not found any whole body or local untoward reaction, illustrate that Chinese medicine preparation of the present invention has no side effect, safe and reliable, there is not any contraindication, wide accommodation can remedy the clinical deficiency that lacks conventional medicine for external use such as " normal saline " that resemble doctor trained in Western medicine, " ethacridine " of surgery of Chinese medicine.The function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, putrefaction-removing granulation-promoting promotes wound healing, improves non-specific immunity.Can treat skin infection burst back or incision and drainage and diseases such as trauma infection contamination, carbuncle, bone tuberculosis, osteomyelitis, burn and scald, cervical erosion and vaginitis, have easy absorption, rapid-action, advantage that curative effect is high.
Chinese medicine preparation of the present invention is like this preparation: Cortex Phellodendri, Herba Taraxaci, Flos Lonicerae, Fructus Forsythiae and Scolopendra water are decocted the back concentrate decoction liquor, carry out precipitate with ethanol with ethanol, filter, get filtrate, steam behind the ethanol adding distil water cold preservation that stirs.
The described precipitate with ethanol of the preparation method of Chinese medicine preparation of the present invention, purpose are the impurity of removing in the decoction liquor.
The preparation method of Chinese medicine preparation of the present invention can also comprise carries out suction strainer with the solution after the cold preservation, removes precipitation.
The preparation method of Chinese medicine preparation of the present invention can also comprise and will carry out disinfection after the solution packing after the cold preservation.
The preparation method of the Chinese medicine preparation that is used for the treatment of skin infection and trauma infection contamination of the present invention is scientific and reasonable, simple for process, and the medicine source is enriched inexpensive, and cost is low, and high efficiency is easy to promote.
The present invention will be further described below in conjunction with embodiment.
Embodiment
Take by weighing following raw material respectively:
Cortex Phellodendri 50g, Herba Taraxaci 50g, Flos Lonicerae 60g, Fructus Forsythiae 90g, Scolopendra 3g
With above-mentioned all raw material mixing decoctings, add ethanol after decoction liquor concentrated and carry out precipitate with ethanol, remove contamination precipitation, obtain filtrate after the filtration, carry out ethanol and reclaim back adding distil water mix homogeneously cold preservation, with suction filtration precipitation is removed the back packing, carrying out disinfection is finished product again.
This Chinese medicine preparation has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, and the effect of promoting tissue regeneration by removing blood stasis can be treated skin infection or incision and drainage and trauma infection contamination, carbuncle, bone tuberculosis, osteomyelitis, burn and scald, cervical erosion, vaginitis etc.
This Chinese medicine preparation can use like this: the sliver that directly will be soaked with this Chinese medicine preparation spreads in the infected wound outward, or in the abscess of ulceration, if ulcer is darker, the aseptic sebific duct of available diameter 0.5-1.0cm, insert the ulcer bottom, extract the flushing of this Chinese medicine preparation with syringe, once a day.
Claims (4)
1, a kind of Chinese medicine preparation that is used for the treatment of skin infection and trauma infection contamination, it is characterized in that be by the raw material of following parts by weight through decocting, concentrate, add water behind the precipitate with ethanol and make:
30～60 parts of 30～60 parts of Herba Taraxacis of Cortex Phellodendri
60～120 parts of 40～80 parts of Fructus Forsythiaes of Flos Lonicerae
1.6～4.8 parts of Scolopendras.
2, a kind of preparation method of Chinese medicine preparation as claimed in claim 1, it is characterized in that Cortex Phellodendri, Herba Taraxaci, Flos Lonicerae, Fructus Forsythiae and Scolopendra water are decocted the back concentrates decoction liquor, carry out the precipitate with ethanol after-filtration with ethanol, filtrate is steamed ethanol, the cold preservation of adding distil water mix homogeneously.
3, preparation method as claimed in claim 2 is characterized in that the solution after the cold preservation is carried out suction strainer.
4, preparation method as claimed in claim 2 is characterized in that and will carry out disinfection after the solution packing after the cold preservation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106739A CN1057218C (en) | 1996-07-01 | 1996-07-01 | Chinese medicine preparation for sore, ulcer and infection caused by external wound and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106739A CN1057218C (en) | 1996-07-01 | 1996-07-01 | Chinese medicine preparation for sore, ulcer and infection caused by external wound and preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1169863A CN1169863A (en) | 1998-01-14 |
| CN1057218C true CN1057218C (en) | 2000-10-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96106739A Expired - Lifetime CN1057218C (en) | 1996-07-01 | 1996-07-01 | Chinese medicine preparation for sore, ulcer and infection caused by external wound and preparation method |
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| CN (1) | CN1057218C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1325681A1 (en) * | 2001-12-11 | 2003-07-09 | Société des Produits Nestlé S.A. | Composition for promotion of bone growth and maintenance of bone health |
| EP1325682A1 (en) * | 2001-12-11 | 2003-07-09 | Societe Des Produits Nestle S.A. | Food or pet food composition containing plant extracts for maintenance of bone health and prevention or treatment of bone diseases |
| CN103070928B (en) * | 2013-01-05 | 2014-10-08 | 山西农业大学 | Cataplasm of veterinary traditional Chinese medicine clearing away heat and toxic materials and preparation method of cataplasm |
| CN107582698A (en) * | 2017-10-27 | 2018-01-16 | 于忠和 | A kind of preparation method for the Chinese medicine for treating scald |
| CN108245622A (en) * | 2018-02-24 | 2018-07-06 | 山东汉方制药有限公司 | A kind of preparation method and applications of Chinese medicine composition |
| CN108992481A (en) * | 2018-10-12 | 2018-12-14 | 张金木 | For anti-curing oncoma and the Chinese medicine composition of osteomyelitis and preparation method thereof |
| CN113975327A (en) * | 2021-12-10 | 2022-01-28 | 山东汉方制药有限公司 | Application of compound phellodendron bark liquid liniment in preparing medicine for treating myeloproliferative tumor |
-
1996
- 1996-07-01 CN CN96106739A patent/CN1057218C/en not_active Expired - Lifetime
Non-Patent Citations (4)
| Title |
|---|
| 中国中西医结合杂志 1994 14卷第4期 1994.1.1 作者，扬宝民，蔡建荣，陈瑞文等 标题 微波热疗加溃疡灵治理\料溃疡 * |
| 江苏中医 92-13-4 1992.1.1 作者，谢正平 标题 溃疡灵液治料36例 * |
| 河南医学学报 1990年第13卷第4期 1990.1.1 作者 谢正平 标题 自拟通络解毒汤治料小腿慢性溃疡27例 * |
| 河南医学学报 1990年第13卷第4期 1990.1.1 作者 谢正平 标题 自拟通络解毒汤治料小腿慢性溃疡27例;江苏中医 92-13-4 1992.1.1 作者，谢正平 标题 溃疡灵液治料36例;中国中西医结合杂志 1994 14卷第4期 1994.1.1 作者，扬宝民，蔡建荣，陈瑞文等 标题 微波热疗加溃疡灵治理\料溃疡 * |
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| Publication number | Publication date |
|---|---|
| CN1169863A (en) | 1998-01-14 |
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