CN106174462A - The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method - Google Patents
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method Download PDFInfo
- Publication number
- CN106174462A CN106174462A CN201610234258.7A CN201610234258A CN106174462A CN 106174462 A CN106174462 A CN 106174462A CN 201610234258 A CN201610234258 A CN 201610234258A CN 106174462 A CN106174462 A CN 106174462A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- vitis viniferae
- particle
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 48
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 36
- 238000009472 formulation Methods 0.000 title claims abstract description 32
- 239000002105 nanoparticle Substances 0.000 title claims abstract description 31
- 206010055031 vascular neoplasm Diseases 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims description 20
- 238000003672 processing method Methods 0.000 title claims description 10
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 241000252335 Acipenser Species 0.000 claims abstract description 10
- 210000004712 air sac Anatomy 0.000 claims abstract description 10
- 239000003814 drug Substances 0.000 claims description 48
- 235000009392 Vitis Nutrition 0.000 claims description 44
- 241000219095 Vitis Species 0.000 claims description 44
- 210000000582 semen Anatomy 0.000 claims description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 40
- 239000007788 liquid Substances 0.000 claims description 30
- 235000016709 nutrition Nutrition 0.000 claims description 26
- 239000000843 powder Substances 0.000 claims description 25
- 239000011159 matrix material Substances 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 235000001014 amino acid Nutrition 0.000 claims description 19
- 229940024606 amino acid Drugs 0.000 claims description 19
- 150000001413 amino acids Chemical class 0.000 claims description 19
- 229940088594 vitamin Drugs 0.000 claims description 19
- 229930003231 vitamin Natural products 0.000 claims description 19
- 235000013343 vitamin Nutrition 0.000 claims description 19
- 239000011782 vitamin Substances 0.000 claims description 19
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 19
- 235000007164 Oryza sativa Nutrition 0.000 claims description 16
- 241000209094 Oryza Species 0.000 claims description 15
- 238000001914 filtration Methods 0.000 claims description 15
- 238000002372 labelling Methods 0.000 claims description 15
- 235000009566 rice Nutrition 0.000 claims description 15
- 229920002261 Corn starch Polymers 0.000 claims description 13
- 239000008120 corn starch Substances 0.000 claims description 13
- 238000000605 extraction Methods 0.000 claims description 13
- 239000008187 granular material Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 238000007710 freezing Methods 0.000 claims description 12
- 239000000835 fiber Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 230000008014 freezing Effects 0.000 claims description 9
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 238000001802 infusion Methods 0.000 claims description 9
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims description 8
- 241001523681 Dendrobium Species 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 7
- TVQGDYNRXLTQAP-UHFFFAOYSA-N ethyl heptanoate Chemical compound CCCCCCC(=O)OCC TVQGDYNRXLTQAP-UHFFFAOYSA-N 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
- 102000004190 Enzymes Human genes 0.000 claims description 6
- 108090000790 Enzymes Proteins 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 235000013372 meat Nutrition 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 5
- 239000004472 Lysine Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 5
- 239000004475 Arginine Substances 0.000 claims description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- 239000003390 Chinese drug Substances 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 4
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 4
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims description 4
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 4
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 4
- 229960002173 citrulline Drugs 0.000 claims description 4
- 235000013477 citrulline Nutrition 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 4
- 229960000310 isoleucine Drugs 0.000 claims description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
- 229960003104 ornithine Drugs 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 4
- 238000005550 wet granulation Methods 0.000 claims description 4
- 241000251468 Actinopterygii Species 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 3
- 229910021529 ammonia Inorganic materials 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000009413 insulation Methods 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 3
- 238000010025 steaming Methods 0.000 claims description 3
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 2
- 239000004375 Dextrin Substances 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 235000010216 calcium carbonate Nutrition 0.000 claims description 2
- 235000019425 dextrin Nutrition 0.000 claims description 2
- 239000004833 fish glue Substances 0.000 claims description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 2
- 239000001095 magnesium carbonate Substances 0.000 claims description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 2
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 239000004744 fabric Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 24
- 210000004369 blood Anatomy 0.000 abstract description 23
- 210000003734 kidney Anatomy 0.000 abstract description 14
- 230000001737 promoting effect Effects 0.000 abstract description 11
- 201000011066 hemangioma Diseases 0.000 abstract description 10
- 230000017531 blood circulation Effects 0.000 abstract description 8
- 230000036039 immunity Effects 0.000 abstract description 8
- 239000003440 toxic substance Substances 0.000 abstract description 8
- 231100000614 poison Toxicity 0.000 abstract description 7
- 230000008901 benefit Effects 0.000 abstract description 6
- 239000003053 toxin Substances 0.000 abstract description 5
- 231100000765 toxin Toxicity 0.000 abstract description 5
- 230000000694 effects Effects 0.000 description 19
- 230000000052 comparative effect Effects 0.000 description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 12
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 10
- 229930014669 anthocyanidin Natural products 0.000 description 10
- 150000001452 anthocyanidin derivatives Chemical class 0.000 description 10
- 235000008758 anthocyanidins Nutrition 0.000 description 10
- 230000006870 function Effects 0.000 description 10
- 210000004185 liver Anatomy 0.000 description 10
- 210000002784 stomach Anatomy 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 8
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 8
- 229930003270 Vitamin B Natural products 0.000 description 7
- 235000019156 vitamin B Nutrition 0.000 description 7
- 239000011720 vitamin B Substances 0.000 description 7
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 6
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 6
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 6
- 229930003268 Vitamin C Natural products 0.000 description 6
- 230000001093 anti-cancer Effects 0.000 description 6
- 210000004204 blood vessel Anatomy 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 6
- 230000036541 health Effects 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 6
- 210000000952 spleen Anatomy 0.000 description 6
- 235000013619 trace mineral Nutrition 0.000 description 6
- 239000011573 trace mineral Substances 0.000 description 6
- 235000019154 vitamin C Nutrition 0.000 description 6
- 239000011718 vitamin C Substances 0.000 description 6
- 241001465754 Metazoa Species 0.000 description 5
- 229930003427 Vitamin E Natural products 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 235000005911 diet Nutrition 0.000 description 5
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 5
- 210000002216 heart Anatomy 0.000 description 5
- 210000000936 intestine Anatomy 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 235000019165 vitamin E Nutrition 0.000 description 5
- 239000011709 vitamin E Substances 0.000 description 5
- 229940046009 vitamin E Drugs 0.000 description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 4
- 206010011224 Cough Diseases 0.000 description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 230000000378 dietary effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 235000013312 flour Nutrition 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 235000008935 nutritious Nutrition 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- 235000019158 vitamin B6 Nutrition 0.000 description 4
- 239000011726 vitamin B6 Substances 0.000 description 4
- 229940045997 vitamin a Drugs 0.000 description 4
- 229940011671 vitamin b6 Drugs 0.000 description 4
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 3
- 229930003451 Vitamin B1 Natural products 0.000 description 3
- 229930003779 Vitamin B12 Natural products 0.000 description 3
- 229930003471 Vitamin B2 Natural products 0.000 description 3
- 229930003316 Vitamin D Natural products 0.000 description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 3
- 229930003448 Vitamin K Natural products 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 3
- 229960002685 biotin Drugs 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 239000011616 biotin Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 3
- 229960001231 choline Drugs 0.000 description 3
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 235000013325 dietary fiber Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 229960000304 folic acid Drugs 0.000 description 3
- 235000019152 folic acid Nutrition 0.000 description 3
- 239000011724 folic acid Substances 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 208000019423 liver disease Diseases 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 229960003512 nicotinic acid Drugs 0.000 description 3
- 235000001968 nicotinic acid Nutrition 0.000 description 3
- 239000011664 nicotinic acid Substances 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 230000000050 nutritive effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 229940055726 pantothenic acid Drugs 0.000 description 3
- 235000019161 pantothenic acid Nutrition 0.000 description 3
- 239000011713 pantothenic acid Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 235000019175 phylloquinone Nutrition 0.000 description 3
- 239000011772 phylloquinone Substances 0.000 description 3
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 3
- 229960001898 phytomenadione Drugs 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 229960002477 riboflavin Drugs 0.000 description 3
- 229910052711 selenium Inorganic materials 0.000 description 3
- 239000011669 selenium Substances 0.000 description 3
- 238000005728 strengthening Methods 0.000 description 3
- 229960003495 thiamine Drugs 0.000 description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 3
- 230000035922 thirst Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 230000001988 toxicity Effects 0.000 description 3
- 239000004474 valine Substances 0.000 description 3
- 235000010374 vitamin B1 Nutrition 0.000 description 3
- 239000011691 vitamin B1 Substances 0.000 description 3
- 235000019163 vitamin B12 Nutrition 0.000 description 3
- 239000011715 vitamin B12 Substances 0.000 description 3
- 235000019164 vitamin B2 Nutrition 0.000 description 3
- 239000011716 vitamin B2 Substances 0.000 description 3
- 235000019166 vitamin D Nutrition 0.000 description 3
- 239000011710 vitamin D Substances 0.000 description 3
- 150000003710 vitamin D derivatives Chemical class 0.000 description 3
- 235000019168 vitamin K Nutrition 0.000 description 3
- 239000011712 vitamin K Substances 0.000 description 3
- 150000003721 vitamin K derivatives Chemical class 0.000 description 3
- 229940046008 vitamin d Drugs 0.000 description 3
- 229940046010 vitamin k Drugs 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 208000015220 Febrile disease Diseases 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 206010039509 Scab Diseases 0.000 description 2
- 231100000403 acute toxicity Toxicity 0.000 description 2
- 230000007059 acute toxicity Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 235000004279 alanine Nutrition 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- -1 calcareous Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000007665 chronic toxicity Effects 0.000 description 2
- 231100000160 chronic toxicity Toxicity 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000007952 growth promoter Substances 0.000 description 2
- 208000035861 hematochezia Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 235000012907 honey Nutrition 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 230000008337 systemic blood flow Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- PEYUIKBAABKQKQ-AFHBHXEDSA-N (+)-sesamin Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-AFHBHXEDSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 102100034279 Calcium-binding mitochondrial carrier protein Aralar2 Human genes 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013952 Dysphonia Diseases 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- 108010001515 Galectin 4 Proteins 0.000 description 1
- 102100039556 Galectin-4 Human genes 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 208000010473 Hoarseness Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000015817 Infant Nutrition disease Diseases 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- 244000062793 Sorghum vulgare Species 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 208000009443 Vascular Malformations Diseases 0.000 description 1
- 208000006288 Vascular Tissue Neoplasms Diseases 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 210000000648 angioblast Anatomy 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 208000002399 aphthous stomatitis Diseases 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 208000029185 blood vessel neoplasm Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000003177 cardiotonic effect Effects 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 108010084210 citrin Proteins 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 235000019784 crude fat Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- PEYUIKBAABKQKQ-UHFFFAOYSA-N epiasarinin Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=C3OCOC3=C2)=C1 PEYUIKBAABKQKQ-UHFFFAOYSA-N 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 1
- 235000003969 glutathione Nutrition 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- VRMHCMWQHAXTOR-CMOCDZPBSA-N sesamin Natural products C1=C2OCOC2=CC([C@@H]2OC[C@@]3(C)[C@H](C=4C=C5OCOC5=CC=4)OC[C@]32C)=C1 VRMHCMWQHAXTOR-CMOCDZPBSA-N 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000004206 stomach function Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 201000011531 vascular cancer Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor of the present invention, be made up of the raw material of following weight portion: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts, Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts, Cornu Saigae Tataricae 3 parts, Rhizoma Coptidis 10 parts, 8 parts of Radix Glycyrrhizae, Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts, Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser.The invention have the advantage that inventive formulation heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, tonify Qi of the kidney and can treat hemangioma, improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue simultaneously.
Description
Technical field
The present invention relates to the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, in particular, relate to a kind of preventing and treating
Angiomatous nutrient formulation nano-particle and preparation method thereof technical field.
Background technology
Hemangioma is congenital benign tumor or vascular malformation, and it originates from the embryo angioblast of remnants, active
Endothelium sample plumule invades to adjacent tissue, forms endothelium batten rope, is connected with left blood vessel through Guan Huahou and forms blood vessel
Tumor, blood vessel self-organizing system in tumor, it is not connected with peripheral vessels.The hemangioma betiding oromaxillo-facial region accounts for system vascular tumor
60%, wherein great majority betide facial skin, subcutaneous tissue and oral mucosa, as at the bottom of tongue, lip, mouth etc. tissue, minority betides
In jawbone or deep tissue.Being blood stasis venation from traditional Chinese medical science angle, scorchingly hot knot gather, pyretic toxicity and blood are binded up one's hair mutually in venation.The traditional Chinese medical science is recognized
For by heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, tonify Qi of the kidney and can treat hemangioma.
For threpsology's angle, hemangioma is in addition to taking regular Therapeutic Method and treating, it is also noted that diet
Treatment, the nutrient that supply is sufficient, reasonably combined dietary structure.The present invention combines dietetic nutrition regulation and Chinese medicine formula just
Make a kind of have supplement the nutrients and the health food granule of auxiliary treatment dual-use function, improve body immunity, anti-ageing simultaneously
Always, eliminating toxin and beautifying the skin, nourishing taste, drop three-hypers, prevent and treat diabetes and anti-cancer, the function of the aspect such as anticancer.
Summary of the invention
The present invention is directed to the deficiency of existing product, and provide one to have extra-nutrition, auxiliary treatment, improve self increase
The wriggling of the intestines and stomach, the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor simultaneously strengthening the advantages such as body immunity of curing the disease.
A kind of nutrient formulation nano-particle for the treatment of of vascular tumor, described nutrient formulation nano-particle is by following raw material: Rhizoma Steudnerae Henryanae,
Rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin are processed into；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 5-10 part, rice 1-5 part, Semen setariae 1-15 part,
Corn starch 5-10 part, fructus zizaniae caduciflorae 1-10 part, Semen Sesami Nigrum 1-10 part, aminoacid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of the concentrated liquid of tradition Chinese medicine in described nutrient formulation nano-particle according to weight is: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts,
Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts, Cornu Saigae Tataricae 3 parts, Rhizoma Coptidis 10 parts, 8 parts of Radix Glycyrrhizae, Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts,
Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate；
Described amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene
Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, color ammonia
Acid 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE
0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein,
Several or all mix；Maintain healthy institute required by adding to supplement.
The invention also discloses nutrient formulation nano-particle and the preparation processing method of a kind for the treatment of of vascular tumor, including following
Step；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
E, Radix Platycodonis, Radix Angelicae Sinensis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to 100 DEG C,
Holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats concentration under the conditions of 0.05MPa；Will
Filtering solution, but to less than 50 DEG C, is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85% by filtering solution, after 30 minutes,
Alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts alcohol, obtains Chinese medicine
Extracting solution a；
Radix Rubiae, Radix Salviae Miltiorrhizae, Cornu Saigae Tataricae mix and blend are put into super micron mill, and super micron mill heating keeps 80 degree of 5-6 of temperature
Minute, carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Taking the Radix Rehmanniae, Cortex Moutan, Rhizoma Coptidis, Radix Glycyrrhizae, Cacumen Platycladi, Herba Plantaginis, Radix Paeoniae Rubra, mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes
After, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, freezing medicine block and ultra micro are mixed carefully
Powder boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4
Times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out
Infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule thick
Powder, and within 15 minutes, carry out sterilizing by 100 DEG C of microwave heatings, again granule coarse powder is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out
Wet granulation or one-step palletizing preparing granular.
Further: described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate
In any one.
Further: the step of the wet granulation in described step G is as follows: in mixer-granulator, to add binding agent system
Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, by wet
Grain is placed in boiling drier, inlet temperature 45～85 DEG C, is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～
9.0%；
Further: the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture control
System is 4.0%～9.0%.
Rhizoma Steudnerae Henryanae: its rich in proteins, starch, pectin, cellulose, aminoacid, vitamin and several mineral materials, simultaneously the richest
Containing selenium element and anthocyanidin, the special health care of the nutritious tool of Rhizoma Steudnerae Henryanae, gal4 amino acid therein is all easily by human body
Digest and absorb；Wherein rich in vitamin A can improve the mucomembranous epithelial cell of vision and skin, vitamin C can
Making collagen protein normally synthesize, prevent and treat scorbutic generation, anthocyanidin is natural potent free radical scavenger, has common Radix Ipomoeae
Nutritional labeling outside, also rich in selenium element, ferrum element and anthocyanidin.
Semen setariae: Semen setariae is also known as Semen setariae, is standing grain ancient times, is the product after millet is shelled.In addition to abundant irony, Semen setariae
Also there is protein, compound vitamin B, calcareous, potassium, cellulose etc..Semen setariae is contained within the multiple functional factor useful to property, energy
Tonifying YANG, YIN nourishing, aristogenesis.
The rice traditional Chinese medical science thinks that nature and flavor are sweet flat, has invigorating the spleen and replenishing QI, strengthening the spleen and nourishing the stomach, the strong will of benefit essence and the five internal organs, promoting blood circulation, audition improvement
Improving eyesight, be only tired of, quench the thirst, effect of antidiarrheal, it is believed that polyphagia can make us " kept fit color ".
Corn starch is universally acknowledged " gold crop ", and its fat, P elements, the content of vitamin B2 occupy cereal
First of；Containing linoleic acid and vitamin E in Semen Maydis flour, cholesterol in human body level can be made to reduce, thus reduce arteriosclerosis
Occur；Calcic in Semen Maydis flour, irony are more, can prevent hypertension, coronary heart disease；Modern medicine study shows, has rich in Semen Maydis flour
Rich glutathion, this is a kind of anticancer factor, can combine with multiple external chemical carcinogen so that it is lose in human body
Go toxicity, then excreted by digestive tract.Containing substantial amounts of lysine in the Semen Maydis flour of corase grind, tumor growth can be suppressed.
Fructus zizaniae caduciflorae is a kind of medicine, the rice of food dual-purpose, belongs to Oryza glutinosa class.Fructus zizaniae caduciflorae .5% Han protein 12, crude fat 2.7-3.8%,
Carbohydrate 75-84%, coarse ash 1.7-2%.The vitamin C that lacked containing rice, chlorophyll, anthocyanidin, carotene
And the special composition such as cardiotonic glycoside, nutritious, there is good tonic effect.
Semen Sesami Nigrum medicine-food two-purpose, has effects such as " invigorating the liver and kidney, grow the five internal organs, benefiting essence-blood, and intestine moistening is dry ", on the one hand is because containing
There are high quality protein and abundant mineral, are on the other hand because containing abundant unsaturated fatty acid, vitamin E and preciousness
Sesamin and melanin.
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, dimension
Raw element B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, biotin are therein
A kind of, several or all mix；Maintain healthy institute required by adding to supplement.
Amino acid whose raw material according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene
Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, color ammonia
Acid 0.01-0.06 part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE
0.01 part, Valine 0.01 part；
The Radix Rehmanniae, sweet in the mouth, cold.Hemopoietic removing heat from blood, cures mainly folding and falls, exhausted muscle, damaging the spleen and stomach, by arthralgia due to stagnation of blood, fills out bone marrow, long muscle.
Cortex Moutan, pungent, bitter, be slightly cold.GUIXIN, liver, kidney channel.For the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, there is clearing away heat and cooling blood effect.
Radix Rubiae can stop blooding in promoting the circulation of blood, dredge the meridian passage, eliminating phlegm and stopping cough.
Radix Salviae Miltiorrhizae, has blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, and clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.
Cornu Saigae Tataricae, suppressing the hyperactive liver to relieve the wind syndrome: Cornu Saigae Tataricae subtracts cold, enter liver, the heart, lung meridian.Main removing fire from the liver, clear away heart-fire lung, removing pathogenic heat from blood and toxic substance from the body, dissipates blood
Removing toxic substances.
Rhizoma Coptidis is bitter；Cold, heart channel；Liver Channel；Stomach warp；Large intestine channel, pathogenic fire purging, dampness, removing toxic substances, parasite killing.Row pyretic toxicity when controlling, typhoid fever,
Intenseness of heat is vexed, feeling of fullness vomiting, bacillary dysentery, and diarrhea of heat type is suffered from abdominal pain, and lung knot is pressed, and tells, is defeated in battle, hematochezia, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, pharynx
Larynx swells and ache, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.
Radix Glycyrrhizae, and middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription
Cacumen Platycladi, cooling blood for hemostasis, preventing phlegm from forming and stopping coughing, it is used for spitting blood, epistaxis, spitting of blood, to have blood in stool, metrostaxis, cough due to lung-heat, heat in blood takes off
Send out, early whitening of beard and hair.
Radix Angelicae Sinensis, blood circulation promoting and blood stasis dispelling, regulation body's immunity, have anticancer, oxygen lack resistant function.
Herba Plantaginis, sweet in the mouth, cold in nature.There is diuresis, heat clearing away, improving eyesight, effect of eliminating the phlegm.
Radix Platycodonis, lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness.
Radix Paeoniae Rubra, bitter, it is slightly cold.Return Liver Channel.There is clearing away heat and cooling blood, effect of blood circulation promoting and blood stasis dispelling.
Air Bladder pseudosciaenae seu Acipenser, sweet, flat, nontoxic.Sweet in the mouth, temperature.Enter kidney.The kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence, controls kidney
Empty spermatorrhea.
Fructus Vitis viniferae nutritive value is the highest, containing mineral calcium, potassium, phosphorus, ferrum and multivitamin B1, vitamin in Fructus Vitis viniferae
B2, vitamin B6, vitamin C and Citrin etc., possibly together with the aminoacid of multiple needed by human body, multiple fruit acid contributes to digestion,
Suitably eat a little Fructus Vitis viniferae more, can be good for Pi stomach function regulating, dry and cracked to tongue body, overfatigue is of great advantage and has.
The natural tradition medicinal and edible Chinese medicine above with multiple health care is share, heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, benefit
Kidney QI invigorating can treat hemangioma.Improve body immunity, defying age, eliminating toxin and beautifying the skin, nourishing taste, the merit of resisting fatigue.By greatly
The proportioning of the amount each component of experiment screening, scientific and reasonable；And whole preparation technology is rationally and extract drugs rate efficiency is high, can be very well
Ground retains the effective ingredient in raw material, does not bring any impurity, and sweet mouthfeel into, has no side effect.
The invention has the beneficial effects as follows:
1, the nutrient formulation nano-particle of the present invention, has promoting the production of body fluid to quench thirst, gastric acid secretion, helps digest, and health body-building has
Tongue body of releiving is dry and cracked, lessens fatigue, containing various trace elements such as calcium, ferrum, zinc, selenium, sodium etc., to improving body immunity, resisting
Aging, eliminating toxin and beautifying the skin, nourishing taste, three-hypers drops, to prevent and treat diabetes and anti-cancer, the aspect such as anticancer the most powerful, regulation human body is raw
Reason function.
2, the present invention is rich in anthocyanidin, it is possible to protection human body is from the damage of free radical, it is possible to strengthens blood vessel elasticity, relax
Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist
Suddenly change, alleviate the function such as hepatosis, protection cardiovascular；
3, add Chinese herbal medicine to there is heat-clearing and toxic substances removing, removing heat from blood and promoting blood circulation, tonify Qi of the kidney and can treat hemangioma, improve body immunity, resist
The functions such as aging, eliminating toxin and beautifying the skin, nourishing taste, resisting fatigue.
4, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has
The highest health care and medical value, life-time service can with YIN nourishing skin care, change skin colour, defying age, life lengthening, and
Carry easy to use, improve self and increase the wriggling of the intestines and stomach, cure the disease and strengthen body immunity simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about
The present invention, but and it is not so limited the present invention.
Embodiment 1
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, described nutrient formulation nano-particle is by following raw material: Rhizoma Steudnerae Henryanae, big
Rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water are processed in right amount；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 8 parts, 2 parts of rice, Semen setariae 5 parts, corn starch
8 parts, fructus zizaniae caduciflorae 8 parts, Semen Sesami Nigrum 8 parts, 0.1 part of aminoacid, the concentrated liquid of tradition Chinese medicine 5 parts, vitamin 0.1 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts, Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts,
Cornu Saigae Tataricae 3 parts, Rhizoma Coptidis 10 parts, 8 parts of Radix Glycyrrhizae, Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts, Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, fish
Fish glue 10 parts, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate；
Described amino acid whose raw material according to weight is: isoleucine 0.02 part, 0.03 part of tyrosine, phenylalanine 0.01
Part, lysine 0.01 part, arginine 0.01 part, histidine 0.01 part, tryptophan 0.01 part, citrulline 0.01 part, ornithine
0.01 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, vitamin B e, vitamin B u, nicotinic acid, folic acid, pantothenic acid, choline, whole mixing of biotin
And weight portion is identical.
The preparation processing method of the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, comprises the following steps；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；Rich in anthocyanidin in Pericarpium Vitis viniferae, it is possible to protection human body is from the damage of free radical, it is possible to strengthen
Blood vessel elasticity, lax blood vessel, increase systemic blood circulation, have certain blood pressure reduction effect；Immune system ability can be strengthened, tool
Have strong anti-oxidation, mutation, alleviate hepatosis, protection function, Pericarpium Vitis viniferae and the Herba Dendrobii fresh bar fiber such as cardiovascular together with stir
Mix to smash and mention anthocyanidin through hydromel, while farthest extracting anthocyanidin, can protect the quality of anthocyanidin.Will
Water soluble dietary fiber adds Matrix Solution and obtains Matrix Solution II, can increase effect of the wriggling of the intestines and stomach, it is ensured that metabolic waste
Normally excrete；Adsorbing various metabolic waste, be allowed to normally excrete, the comprehensive utilization value improving Herba Dendrobii improves simultaneously
The human body absorption to Chinese medicine ingredients.
E, Radix Platycodonis, Radix Angelicae Sinensis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to
100 DEG C, holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats under the conditions of 0.05MPa
Concentrate；By filtering solution but to less than 50 DEG C, filtering solution is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85%, 30
After minute, alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts alcohol,
Obtain Chinese medicine extraction liquid a；
Radix Rubiae, Radix Salviae Miltiorrhizae, Cornu Saigae Tataricae mix and blend are put into super micron mill, and super micron mill heating keeps 80 degree of 5-6 of temperature
Minute, carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Taking the Radix Rehmanniae, Cortex Moutan, Rhizoma Coptidis, Radix Glycyrrhizae, Cacumen Platycladi, Herba Plantaginis, Radix Paeoniae Rubra, mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes
After, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, freezing medicine block and ultra micro are mixed carefully
Powder boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4
Times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out
Infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule coarse powder, and pass through
100 DEG C of microwave heatings carry out sterilizing for 15 minutes, granule coarse powder is put into nanometered disposal equipment again and carries out pure physical pulverization process
It is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out wet method system
Grain, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, put by wet granular
In boiling drier, inlet temperature 45～85 DEG C, it is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～9.0%.
Comparative example 2
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, processing method and other nutritional labelings are with embodiment 1, described Chinese medicine
The prescription of concentrated solution according to weight is: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts, Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts, Cornu Saigae Tataricae 3 parts, river
10 parts of company, 8 parts of Radix Glycyrrhizae, Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts, Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, new fresh Herba Dendrobii 15 parts, Portugal
15 parts of grape, Mel, water are appropriate；Compare without Air Bladder pseudosciaenae seu Acipenser composition with embodiment 1.
Comparative example 3
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, other nutritional labelings are pressed with embodiment 1, the prescription of the concentrated liquid of tradition Chinese medicine
According to weight be: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts, Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts, Cornu Saigae Tataricae 3 parts, Rhizoma Coptidis 10 parts, 8 parts of Radix Glycyrrhizae,
Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts, Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, 10 parts of Air Bladder pseudosciaenae seu Acipenser, water are appropriate.Compare with embodiment 1
Without new fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and the Matrix Solution I being processed into, Matrix Solution II.Preparation for processing is: real
Execute E and G of example 1 procedure of processing.
Comparative example 4
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, compares with embodiment 1 and forms sediment without Rhizoma Steudnerae Henryanae, rice, Semen setariae, Semen Maydis
The nutritional labelings such as powder, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other are the most same as in Example 1.
Comparative example 5
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, compares with embodiment 1 without the trace such as aminoacid, vitamin unit
Element；Other are the most same as in Example 1.
Comparative example 6
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, compares with embodiment 1: form sediment without Rhizoma Steudnerae Henryanae, rice, Semen setariae, Semen Maydis
Nutritional labeling and the trace element such as aminoacid, vitamin such as powder, fructus zizaniae caduciflorae, Semen Sesami Nigrum；Other are the most same as in Example 1.
Comparative example 7
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor, compares with embodiment 1: except for the difference that, produces the concentrated liquid of tradition Chinese medicine, logical
Cross medical material add water direct boiling method prepare.
Clinical experiment divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1, animal acute toxicity test
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritive powder.
Experimental animal: regular grade NIH mice, body weight 18g ± 2g, male and female half and half.
Method and result:
By each for nutritional granular 50g, adding water, the nutritional granular powder made is stuck with paste.Experiment mice is randomly divided into 7 groups of male and female half and half,
7 kinds of nutritional granular powder of feeding are stuck with paste respectively, volume 1ml/10g body weight, and close observation 8 hours is also noted down, and continue to observe 7 days；7
In it, mice is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, eye, mouth, nose, ear and
Crissum secretions without exception, without the rotten toe that docks.Respectively from 7 groups select 2 execution, finding of naked eye: the heart, liver, lung, gastric and
The important organs such as thymus, no abnormality seen changes, shows that two kinds of these nutritive powders are all without acute toxicity.
2, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritional granular nutritional granular powder made that adds water is stuck with paste.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that 7 kinds of nutritional granular powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively the 200 of edible for patients amount, 100,
50g；Experimental mouse is randomly divided into 7 groups, and the nutritional granular powder that feeding modulates continuously respectively is stuck with paste, and continuous feeding 40 days is observed dynamic
Thing general toxic reaction and the order of severity, place after death by rule of operation check each position, and carry out hematology, ALT, BUN and
The pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Growth promoter is good.Macroscopic appearance and main organs have no
Abnormal.Peripheral hemogram and Serum ALT, BUN compare with matched group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach
Deng the most significant change, it is understood that through proved by pathology, 7 kinds of nutritional granular powder are stuck with paste animal without chronic toxicity table
Existing.
By two above toxicity test, it was demonstrated that the nutritional granular that the present invention is made by embodiment 1 and comparative example is
Safety, have no side effect, can be used to clinical patients is carried out clinical trial.
3, embodiment of the present invention using effect investigation:
(1) investigation method:
1. crowd is used: general population
2. the time is used: 90 days
3. number of users: 100 people
4. using method: the most soaked 500 mL
5. index: hemangioma reduces, form a scab clinical symptom disappearance, and mouthfeel is the most sour-sweet for effective；Drink rear hemangioma to reduce,
Do not form a scab, and mouthfeel is the most sour-sweet, be designated as effectively.Drink rear hemangioma without be obviously reduced comfort be then designated as invalid.
(2) survey result
Survey result is shown in Table 1.
Table 1 each embodiment using effect application form
Conclusion:
Be can be seen that by the data of comparative example 2, the ratio of invalid number is compared with embodiment 1, adds 8%, shows Air Bladder pseudosciaenae seu Acipenser
In Chinese medicine formula, serve priming return through, the function heightened the effect of a treatment, improve the human body assimilation effect to medicine；Bolus for invigorating kidney and improving,
Kidney has the function that Tibetan, main store essential substances, main growth promoter and reproduction are taken the photograph by main department, the liquefaction of main water is thanked.Normal renal function then vital essence fills,
The all dirty negative and positive of whole body disease the most prosperous, all disappears；Conversely, as the impact or worn with age of various paathogenic factors, renal function can be caused and lose
Often.Owing to Air Bladder pseudosciaenae seu Acipenser is a kind of rich sticking material, containing the nutritional labelings such as profuse protein, vitamin, mineral, institute
Have with, fish bubble that the kidney invigorating waist knee joint empty, strong, yin nourishing benefit be smart and the effect of moist skin care.For having a delicate constitution, Kidney-Yin loss, spirit
The personage overwork, overworked is the most suitable.
The data compared with embodiment 1 by comparative example 3 can be seen that, without new fresh Herba Dendrobii, Fructus Vitis viniferae, honey component and
Matrix Solution I, the Matrix Solution II being processed into；The ratio of invalid number is compared with embodiment 1, adds 7 times；And it is effective
The average time of rate, having compared many 5 days than embodiment 1, (i.e. feeling effective, the average time of clinical symptom disappearance is many 5
My god；This shows that the preparation for processing of the present invention makes the concentrated liquid of tradition Chinese medicine prescription and the composition such as water soluble dietary fiber and Oleum Vitis viniferae
Between create mutually collaborative pharmacological action, water soluble dietary fiber increases effect of the wriggling of the intestines and stomach and promotes that human body is to medicine
The absorption of composition, it is ensured that metabolic waste normally excretes, the anthocyanidin additionally contained in Pericarpium Vitis viniferae, resveratrol, have strong
Antioxidation, mutation, alleviate hepatosis, the protection function such as cardiovascular, strengthen immune system ability；Associate with raising with Chinese medicine
Assimilation effect, improves the mouthfeel of Chinese medicine simultaneously, meticulously configuring and the extraction of at utmost ingredient through the present invention, this
Bright traditional Chinese drug inspissation formula of liquid and preparation method occur in that beat all technique effect.
Compared with embodiment 1 by the data of comparative example 4 and can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch,
The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum, the ratio of invalid number is compared with embodiment 1, adds 10 times, and the number of obvious effective rate
Also reduced, show the nutritional labeling the concentrated liquid of tradition Chinese medicines such as the Rhizoma Steudnerae Henryanae of the present invention, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum
Drug effect between create mutually collaborative pharmacological action, the nutrient that supply human body is sufficient, dietary structure is reasonably combined,
Nutritional labeling supplements the necessary energy of human body, reaches balanced nutritious, promotes the health absorption to medicine.
Compared with embodiment 1 by comparative example 5, the trace element such as aminoacid, vitamin；Supplementary needed by human body is wanted
Highly important effect is had during nutrient and trace element regulation physiological function, catalysis metabolic adsorption medicine.
The data compared with embodiment 1 by comparative example 6 can be seen that, without Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch,
The nutritional labeling such as fructus zizaniae caduciflorae, Semen Sesami Nigrum and the trace element such as aminoacid, vitamin；Inefficiency number nearly 15 times and effective percentage number
Also nearly 20% is declined；And the average time of obvious effective rate, compare many 7 days than embodiment 1 and (i.e. felt effective people, clinical condition
The average time that shape disappears is many 7 days；Illustrate nutritional labeling and trace element human body medicine absorb during played and
Its important synergism, greatly promotes human body and recovers medicine and the absorption of nutrition, quickening human body.
The data compared with embodiment 1 by comparative example 7 can be seen that, medical material adds water direct boiling method and the present invention
Chinese medicine preparation method compare, the preparation method of the present invention, the extraction of drug effect is far longer than traditional adding water and directly boils
Method, the extraction degree of active ingredient has had huge raising.
In sum, the preparation processing method of the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor that the present invention provides,
Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Qinghua are damp and hot, the medicine that regulating qi-flowing for harmonizing stomach can prevent and treat chronic superficial gastritis and nutritional labeling is mutually worked in coordination with
Reason effect, the nutrient that supply human body is sufficient, dietary structure is reasonably combined, and nutritional labeling supplements the necessary energy of human body, reaches
To balanced nutritious, promoting the health absorption to medicine, all raw materials are all from medicine-food two-purpose natural plants, have no side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. the nutrient formulation nano-particle of a treatment of vascular tumor, it is characterised in that described nutrient formulation nano-particle is by following
Raw material: Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum, aminoacid, the concentrated liquid of tradition Chinese medicine, vitamin and water are processed in right amount
Make；
Described nutrient formulation nanoparticle raw materials according to weight is: Rhizoma Steudnerae Henryanae 5-10 part, rice 1-5 part, Semen setariae 1-15 part,
Corn starch 5-10 part, fructus zizaniae caduciflorae 1-10 part, Semen Sesami Nigrum 1-10 part, aminoacid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: 8 parts of the Radix Rehmanniae, Cortex Moutan 4 parts, Radix Rubiae 8 parts, Radix Salviae Miltiorrhizae 12 parts,
Cornu Saigae Tataricae 3 parts, Rhizoma Coptidis 10 parts, 8 parts of Radix Glycyrrhizae, Cacumen Platycladi 8 parts, Radix Angelicae Sinensis 8 parts, Herba Plantaginis 8 parts, Radix Platycodonis 8 parts, Radix Paeoniae Rubra 10 parts, fish
Fish glue 10 parts, new fresh Herba Dendrobii 15 parts, Fructus Vitis viniferae 15 parts, Mel, water are appropriate.
The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor the most according to claim 1, it is characterised in that described amino
The raw material of acid according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, phenylalanine 0.01-
0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, tryptophan 0.01-0.06
Part, citrulline 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 part, L-figured silk fabrics ammonia
Acid 0.01 part.
3. the preparation processing method of the nutrient formulation nano-particle of a treatment of vascular tumor, it is characterised in that comprise the following steps；
A, new fresh Herba Dendrobii and Fructus Vitis viniferae are cleaned up, the fresh bar of screening high-quality Herba Dendrobii and Fructus Vitis viniferae, dry standby；
B, new fresh Herba Dendrobii is put into rotating centrifugal juice extractor and carry out Herba Dendrobii juice and separate with fiber stand-by；Again Fructus Vitis viniferae is put into and blow
In wind continuous way quick-freezing plant, by temperature be-40～the air of-30 DEG C makes the surface of Fructus Vitis viniferae tie according to the speed of 3～6m/s
Ice, then carry out Fructus Vitis viniferae meat, Pericarpium Vitis viniferae, Semen Vitis viniferae detached job；By Semen Vitis viniferae through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated Oleum Vitis viniferae is standby；
C, Herba Dendrobii juice and Fructus Vitis viniferae meat are put into mixing drum Matrix Solution I；
D, in hermetically sealed can add be equivalent to dendrobium fiber and the Mel of Pericarpium Vitis viniferae gross weight 20-30% and the steaming of 5-10 times of weight
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, keeps the temperature in hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Pericarpium Vitis viniferae gross weight
Enzyme and the mixing enzyme preparation of protease；Enzymolysis 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, filtering residue deionized water wash；Feed liquid after enzymolysis is homogenizing under the supertension of 80～140MPa, and centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
E, Radix Platycodonis, Radix Angelicae Sinensis, Air Bladder pseudosciaenae seu Acipenser are placed in the distilled water of 40-50 DEG C, soak 20-30min minute, be heated to 100 DEG C,
Holding pressure is at the micro-15min that boils of 0.2MPa, then is filtered by above-mentioned solution；Filtering solution heats concentration under the conditions of 0.05MPa；Will
Filtering solution, but to less than 50 DEG C, is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85% by filtering solution, after 30 minutes,
Alcohol deposit fluid is filtered by 0.3um filter, alcohol deposit fluid obtained above is heated under the conditions of 0.04MPa receipts alcohol, obtains Chinese medicine
Extracting solution a；
Radix Rubiae, Radix Salviae Miltiorrhizae, Cornu Saigae Tataricae mix and blend are put into super micron mill, and super micron mill heating keeps 80 degree of 5-6 of temperature
Minute, carry out micronizing and obtain the ultra micro mixing fine powders of 300-400 mesh；
Taking the Radix Rehmanniae, Cortex Moutan, Rhizoma Coptidis, Radix Glycyrrhizae, Cacumen Platycladi, Herba Plantaginis, Radix Paeoniae Rubra, mix homogeneously adds 30-60 DEG C of warm water soaking 10 minutes
After, put into reach in freezer ,-10～-20 DEG C freezing 10-20 minute, form freezing medicine block, freezing medicine block and ultra micro are mixed carefully
Powder boiling is extracted 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds 4
Times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, carries out
Infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extraction liquid a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add Oleum Vitis viniferae obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as Rhizoma Steudnerae Henryanae, rice, Semen setariae, corn starch, fructus zizaniae caduciflorae, Semen Sesami Nigrum are put into super micron mill, obtain granule thick
Powder, and within 15 minutes, carry out sterilizing by 100 DEG C of microwave heatings, again granule coarse powder is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Granule coarse powder adds aminoacid, vitamin, the concentrated liquid of tradition Chinese medicine and adjuvant and stirs and carry out
Wet granulation or one-step palletizing preparing granular.
The preparation processing method of the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor the most according to claim 3, it is special
Levying and be, it is arbitrary that described adjuvant is selected from dextrin, beta-schardinger dextrin-, soluble starch, microcrystalline Cellulose, magnesium carbonate or calcium carbonate
Kind.
The preparation processing method of the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor the most according to claim 3, it is special
Levying and be, the step of the wet granulation in described step G is as follows: adds binding agent in mixer-granulator and carries out wet granular processed,
Paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, run 10～30 minutes, be placed in by wet granular
Boiling drier, inlet temperature 45～85 DEG C, it is dried 5～30 minutes, obtains granule, control pellet moisture 4.0%～9.0%.
The preparation processing method of the nutrient formulation nano-particle of a kind for the treatment of of vascular tumor the most according to claim 3, it is special
Levying and be, the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, and moisture Control exists
4.0%～9.0%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610234258.7A CN106174462A (en) | 2016-04-17 | 2016-04-17 | The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610234258.7A CN106174462A (en) | 2016-04-17 | 2016-04-17 | The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106174462A true CN106174462A (en) | 2016-12-07 |
Family
ID=57453224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610234258.7A Pending CN106174462A (en) | 2016-04-17 | 2016-04-17 | The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106174462A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1668325A (en) * | 2002-05-10 | 2005-09-14 | 阿根尼克斯有限公司 | Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
| CN104172191A (en) * | 2014-08-18 | 2014-12-03 | 胡安然 | Total-nutrition formula food for treating atherosclerosis |
-
2016
- 2016-04-17 CN CN201610234258.7A patent/CN106174462A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1668325A (en) * | 2002-05-10 | 2005-09-14 | 阿根尼克斯有限公司 | Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
| CN104172191A (en) * | 2014-08-18 | 2014-12-03 | 胡安然 | Total-nutrition formula food for treating atherosclerosis |
Non-Patent Citations (2)
| Title |
|---|
| 宋芳等: "超临界二氧化碳萃取葡萄籽油及其脂肪酸的分析", 《中国食品工业》 * |
| 李文亮: "《千家妙方下》", 31 July 1982 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107296949A (en) | Integration of drinking and medicinal herbs compound formulation and its preparation method and application | |
| CN104017700B (en) | A kind of health preserving wine and preparation method thereof that is in harmonious proportion | |
| CN1742927A (en) | Medicinal tablet made from fruit of Chinese wolfberry and spica Mori and its preparing process | |
| CN106174474A (en) | A kind of it is applicable to the special dietary seafood that Patients with Cardiovascular/Cerebrovascular Diseases is edible | |
| CN104856036B (en) | Health care medicated diet for treating iron-deficiency anemia and preparation method of health care medicated diet | |
| CN105559078A (en) | Composition having blood replenishing efficacy and preparation method thereof | |
| CN113925172A (en) | Giant salamander peptide nutritional composition suitable for children | |
| CN106165885A (en) | A kind of nutrient formulation nano-particle preventing and treating chronic superficial gastritis and preparation processing method | |
| CN106174011A (en) | A kind of nutrient formulation nano-particle preventing and treating diabetes and preparation processing method | |
| CN106173820A (en) | A kind of nutrient formulation nano-particle preventing and treating hypertensive heart disease and preparation processing method | |
| CN106174461A (en) | A kind of nutrient formulation nano-particle preventing and treating Sheehan syndrome and preparation processing method | |
| CN106262801A (en) | A kind of nutrient formulation nano-particle preventing and treating thrombophlebitis and preparation processing method | |
| CN106174463A (en) | A kind of ultra micro nutrition prescription and preparation processing method preventing and treating hypertensive heart disease based on collaborative absorption | |
| CN106174462A (en) | The nutrient formulation nano-particle of a kind for the treatment of of vascular tumor and preparation processing method | |
| CN103610068A (en) | Preparation method for blood-fat-reducing sea cucumber oral liquid | |
| CN106174216A (en) | The neurasthenic ultra micro nutrition prescription of a kind of preventing and treating and preparation processing method | |
| CN106174460A (en) | A kind of nutrient formulation nano-particle preventing and treating cushing's syndrome and preparation processing method | |
| CN106235322A (en) | A kind of prevent and treat the dry and cracked nutrient formulation nano-particle of tongue body and preparation processing method | |
| CN106165747A (en) | One treats deficiency-cold in middle-JIAO food stagnation gastritis medicated tea and preparation processing method | |
| CN106173625A (en) | A kind of nourishing YIN and clearing away lung-heat peaceful network beverage and preparation processing method | |
| CN106174533A (en) | A kind of prevent and treat this about Glenn syndrome nutrient formulation nano-particle and preparation processing method | |
| CN106165807A (en) | A kind of replenishing YIN and removing heat the kidney invigorating beverage and preparation processing method | |
| CN106174465A (en) | A kind of ultra micro nutrition prescription preventing and treating thrombocytopenia and preparation processing method | |
| CN106174536A (en) | A kind of ultra micro nutrition prescription preventing and treating urine protein and preparation processing method | |
| CN106174464A (en) | A kind of ultra micro nutrition prescription preventing and treating hyperlipemia and preparation processing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20161207 |
|
| WD01 | Invention patent application deemed withdrawn after publication |