CN106165884A - A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome and preparation processing method - Google Patents
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome and preparation processing method Download PDFInfo
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- CN106165884A CN106165884A CN201610234252.XA CN201610234252A CN106165884A CN 106165884 A CN106165884 A CN 106165884A CN 201610234252 A CN201610234252 A CN 201610234252A CN 106165884 A CN106165884 A CN 106165884A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome of the present invention, be made up of the raw material of following weight portion: deer's sinew 5 10 parts, parasitic loranthus 10 15 parts, Fructus Chaenomelis 5 10 parts, the seed of jog's tears 10 26 parts, the fruit of glossy privet 10 25 parts, the bark of eucommia 6 15 parts, Radix Codonopsis 5 10 parts, teasel root 5 10 parts, the red sage root 10 15 parts, the root of kudzu vine 10 16 parts, the radix paeoniae rubrathe 10 16 parts, Radix Angelicae Sinensis 10 16 parts, 1 10 parts of air bladder, the fresh stem of noble dendrobium 10 20 parts, grape 10 20 parts, honey, water is appropriate and related nutritional composition.The invention have the advantage that inventive formulation temperature logical dissipates cold, kidney tonifying dehumidifying, acupuncture-stimulating blood stasis dispersing, tune fill blood, cervical spine syndrome can be treated, improve body immunity, anti-aging, toxin-expelling and face nourishing, nourishing taste, the work(of antifatigue.
Description
Technical field
The present invention relates to a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, in particular, relate to one
The nutrient formulation nano particle of preventing and treating cervical spine syndrome and preparation method thereof technical field.
Background technology
Cervical spine syndrome, is osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion
General name, be a kind of with degeneration pathology change into basis illness.Mainly due to cervical vertebra strain for a long time, osteoproliferation, or vertebra
Spondylosis, ligament thicken, and cause cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occur that a series of handicapped clinic is combined
Simulator sickness.Show as vertebra joint unstability, loosen；Nucleus pulposus or abjection；Spur is formed；The plump spinal canal stenosis etc. with secondary of ligament,
Stimulate or oppressed the tissues such as neighbouring nerve root, spinal cord, vertebral artery and neck sympathetic nerve, cause series of symptoms and body
Levy.
The traditional Chinese medical science thinks that cervical spine syndrome is stagnant by asthenia of renal qi, cold-dampness invasion, deficiency of qi and blood, the train of thought stasis of blood, cause nape pain,
Upper myasthenia of limbs, finger are numb, lower limb are weak, difficulty in walking, dizziness, Nausea and vomiting, even blurred vision, tachycardia and gulp down
The symptoms such as pharynx difficulty；By temperature logical dissipate cold, kidney tonifying dehumidifying, acupuncture-stimulating blood stasis dispersing, tune fill blood, and can treat cervical spine syndrome.
For nutrition angle, cervical spine syndrome is in addition to taking regular treatment method and treating, it is also noted that
Dietary therapy, the sufficient nutrient of supply, reasonably combined dietary structure.The present invention combines dietetic nutrition regulation and Chinese medicine just
Formula make a kind of have supplement the nutrients and auxiliary treatment dual-use function health food particle, simultaneously improve body immunity,
Anti-aging, toxin-expelling and face nourishing, nourishing taste, fall three is high, prevent and treat diabetes and the function of anti-cancer, the aspect such as anticancer.
Content of the invention
The present invention is directed to the deficiency of existing product, and provide one to have extra-nutrition, auxiliary treatment, improve self increase
The wriggling of stomach, anti-curing the disease strengthens a kind of nutrient formulation nanometer preventing and treating cervical spine syndrome of the advantages such as body immunity simultaneously
Grain.
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, described nutrient formulation nano particle is by following raw material:
Purple potato, rice, millet, cornstarch, black rice, Semen sesami nigrum, amino acid, the concentrated liquid of tradition Chinese medicine, vitamin are processed into；
Described nutrient formulation nanoparticle raw materials according to weight is: purple potato 5-10 part, rice 1-5 part, millet 1-15 part,
Cornstarch 5-10 part, black rice 1-10 part, Semen sesami nigrum 1-10 part, amino acid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of the concentrated liquid of tradition Chinese medicine in described nutrient formulation nano particle according to weight is: deer's sinew 5-10 part, mulberry are posted
Raw 10-15 part, Fructus Chaenomelis 5-10 part, seed of jog's tears 10-26 part, fruit of glossy privet 10-25 part, bark of eucommia 6-15 part, Radix Codonopsis 5-10 part, teasel root 5-
10 parts, red sage root 10-15 part, root of kudzu vine 10-16 part, radix paeoniae rubrathe 10-16 part, Radix Angelicae Sinensis 10-16 part, air bladder 1-10 part, fresh stem of noble dendrobium 10-20
Part, grape 10-20 part, honey, water are appropriate.
The raw material of described amino acid according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05
Part, phenylalanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part,
Tryptophan 0.01-0.06 part, citrulling 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, the different bright ammonia of L-
Acid 0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one therein,
Several or all mix；Maintain healthy institute required by adding to supplement.
The invention also discloses a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome and preparation processing method, including
Following steps；
A, the fresh stem of noble dendrobium and grape are cleaned up, the fresh bar of the screening high-quality stem of noble dendrobium and grape, dry standby；
B, the fresh stem of noble dendrobium is put into rotating centrifugal juice extractor and carry out stem of noble dendrobium juice and separate with fiber stand-by；Again grape is put into and blow
In wind continous way quick-freezing plant, the air being-40～-30 DEG C by temperature makes the surface of grape tie according to the speed of 3～6m/s
Ice, then carry out grape meat, Grape Skin, grape pip detached job；By grape pip through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated grape-kernel oil is standby；
C, stem of noble dendrobium juice and grape meat are put into mixing drum Matrix Solution I；
D, the steaming adding the honey being equivalent to dendrobium fiber and Grape Skin gross weight 20-30% and 5-10 times of weight in hermetically sealed can
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, the temperature in holding hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Grape Skin gross weight
Enzyme and the mixing enzyme preparation of protease；Digest 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, and filter residue deionized water is washed；Feed liquid after enzymolysis homogeneous under the super-pressure of 80～140MPa, centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
It E, is placed at the bark of eucommia, Radix Codonopsis, teasel root in the distilled water of 40-50 DEG C, soaks 20-30min minute, be heated to 100 DEG C, protect
Hold pressure at the micro-15min that boils of 0.2MPa, more above-mentioned solution is filtered；Filtering solution heats concentration under the conditions of 0.05MPa；Incited somebody to action
Filtering solution, but to less than 50 DEG C, is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85% by filter solution, after 30 minutes, and will
Precipitation solution is filtered by 0.3um filter, precipitation solution obtained above heats under the conditions of 0.04MPa receipts alcohol, obtains Chinese medicine and carry
Take liquid a；
The root of kudzu vine, the radix paeoniae rubrathe, Radix Angelicae Sinensis mix and blend are put into micronizer, and micronizer heating keeps 80 degree of 5-6 minutes of temperature,
Carry out ultramicro grinding and obtain the ultra micro mixing fine powders of 300-400 mesh；
Take deer's sinew, parasitic loranthus, Fructus Chaenomelis, the seed of jog's tears, the fruit of glossy privet, the red sage root, air bladder, mix and add 30-60 DEG C of warm water immersion 10 points
Zhong Hou, puts into reach in freezer ,-10～-20 DEG C of freezing 10-20 minutes, forms freezing medicine block, mixes freezing medicine block and ultra micro
Fine powder adds boiling water extraction 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds
4 times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, enters
Row infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extract a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add grape-kernel oil obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as purple potato, rice, millet, cornstarch, black rice, Semen sesami nigrum are put into micronizer, obtain particle thick
Powder, and within 15 minutes, sterilized by 100 DEG C of heating using microwaves, again particle meal is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Particle meal adds amino acid, vitamin, the concentrated liquid of tradition Chinese medicine and auxiliary material to stir and carry out
Wet granulation or one-step palletizing preparing granular.
Further: described auxiliary material is selected from dextrin, beta-schardinger dextrin, soluble starch, microcrystalline cellulose, magnesium carbonate or calcium carbonate
In any one.
Further: the step of the wet granulation in described step G is as follows: in mixer-granulator, to add adhesive system
Wet granular, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, runs 10～30 minutes, by wet
Grain is placed in boiling drier, EAT 45～85 DEG C, is dried 5～30 minutes, obtains particle, and control pellet moisture 4.0%～
9.0%；
Further: the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture control
System is 4.0%～9.0%.
Purple potato: it is rich in protein, starch, pectin, cellulose, amino acid, vitamin and several mineral materials, simultaneously also rich
Element containing selenium and anthocyanidin, the special health care of the nutritious tool of purple potato, gal4 amino acid therein is all easily by human body
Digest and absorb；Wherein rich in vitamin A can improve the mucomembranous epithelial cell of eyesight and skin, vitamin C can
Making collagen protein normally synthesize, preventing and treating scorbutic generation, anthocyanidin is natural potent free radical scavenger, has common Ipomoea batatas
Nutritional labeling outside, also rich in selenium element, ferro element and anthocyanidin.
Millet: millet is also known as maize, is standing grain ancient times, is the product after millet is shelled.In addition to abundant irony, millet
Also there is protein, compound vitamin B, calcareous, potassium, cellulose etc..Millet is contained within multiple function factor beneficial to property, energy
Establishing-Yang, enriching yin, aristogenesis.
The rice traditional Chinese medical science thinks that nature and flavor are sweet flat, has tonifying middle-Jiao and Qi, strengthening spleen and nourishing stomach, the strong will of benefit essence and the five internal organs, promoting blood circulation, clever ear
Improving eyesight, be only tired of, quench the thirst, effect of antidiarrheal, it is believed that many foods can make us " kept fit color ".
Cornstarch is universally acknowledged " gold crop ", and its fat, P elements, the content of vitamin B2 occupy cereal
First of；Corn flour contains linoleic acid and vitamin E, cholesterol in human body level can be made to reduce, thus reduce artery sclerosis
Occur；In corn flour, calcic, irony are more, can prevent hypertension, coronary heart disease；Modern medicine study shows, has rich in corn flour
Rich glutathione, this is a kind of anticancer factor, can combine with multiple external chemical carcinogens so that it is lose in human body
Go toxicity, then excreted by alimentary canal.The corn flour of corase grind contains substantial amounts of lysine, tumor growth can be suppressed.
Black rice is a kind of medicine, the rice of food dual-purpose, belongs to glutinous rice class.Black rice .5% containing protein 12, crude fat 2.7-3.8%,
Carbohydrate 75-84%, coarse ash 1.7-2%.The vitamin C that lacked containing rice, chlorophyll, anthocyanidin, carrotene
And the special composition such as cardiac glycoside, nutritious, there is good tonic effect.
Semen sesami nigrum medicine-food two-purpose, has effects such as " filling liver kidney, grow the five internal organs, benefiting essence-blood, and ease constipation is dry ", on the one hand is because containing
Have good protein and abundant mineral matter, be on the other hand because containing abundant unrighted acid, vitamin E and preciousness
Sesamin and melanin.
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, dimension
Raw element B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin are therein
A kind of, several or all mix；Maintain healthy institute required by adding to supplement.
The raw material of amino acid according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, benzene
Alanine 0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, look ammonia
Acid 0.01-0.06 part, citrulling 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE
0.01 part, Valine 0.01 part；
Deer's sinew, kidney-replenishing, strengthens the bone.Cure mainly: control excessive, the rheumatic arthritis that strains.
Parasitic loranthus, is used for filling liver kidney, strengthening the bones and muscles, wines used as antirheumatic, antiabortive unit.
Fructus Chaenomelis, relaxing muscles and tendons arm alive, and the effect of stomach dampness elimination.Be mainly used in treat heatstroke, choleraic myospasm, tinea pedis oedema, wet
The symptoms such as numbness, rheumatic arthralgia.In addition, also anti-vascular sclerosis, the effect such as reduce blood pressure.
The seed of jog's tears, clearing damp and promoting diuresis, can dry except wind, clearing away heat and eliminating pus, remove numbness pain relieving, to difficult urination, oedema, tinea pedis and
The effects such as rheumatalgia pain are notable.
The fruit of glossy privet, sweet, bitter, cold.Returning liver, kidney channel, tonifying the liver and kidney, improving eyesight, by the main lung of kidney, clearind deficient heat.
The bark of eucommia, filling liver kidney, strengthening the bones and muscles.
Radix Codonopsis, sweet, flat.Tonifying middle-Jiao and Qi, and stomach promotes the production of body fluid, expelling phlegm and arresting coughing, for weakness of the spleen and the stomach, qi-blood deficiency, body is tired unable,
Food is few, thirsty.
Teasel root: filling liver kidney;Strengthening the bones and muscles;Adjust blood vessels;Continuous injured;Only uterine bleeding.For aching pain in waist and back;Podomere impotence numbness;Fall and flutter wound
Wound, damage muscle folding bone, movement of the foetus red, the metrorrhagia of leakage, seminal emission, under band, ulcer sore swells.
The red sage root, has promoting blood circulation, inducing meastruation to relieve menalgia, and clear away heart-fire relieving restlessness, and cool blood disappears effect of carbuncle
The root of kudzu vine, sweet, pungent, cool.Expelling pathogenic factors from muscles and skin is had to bring down a fever, promoting eruption, promote the production of body fluid to quench thirst, rise the work(of sun antidiarrheal.
The radix paeoniae rubrathe, bitter, it is slightly cold.Return Liver Channel.There is clearing heat and cooling blood, effect of promoting blood circulation.
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, the spleen channel, enrich blood；Invigorate blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.
Air bladder, sweet, flat, nontoxic.Taste is sweet, temperature.Enter kidney.Tonifying kidney and benefiting sperm, nourishes muscle arteries and veins, hemostasis, dissipates the stasis of blood, detumescence, controls kidney
Empty involuntary emission.
Grape nutritive value is very high, containing mineral calcium, potassium, phosphorus, iron and multivitamin B1, vitamin in grape
B2, vitamin B6, vitamin C and citrin etc., possibly together with the amino acid of multiple needed by human body, multiple tartaric acid contribute to digestion,
Suitably eating a little grape more, being good for Pi and stomach, to neurasthenia, excessive fatigue is of great advantage and has.
Sharing the natural tradition medicinal and edible Chinese medicine above with multiple health care, temperature is logical dissipates cold, kidney tonifying dehumidifying, logical
Network stagnation resolvation, adjust and fill blood, can treat cervical spine syndrome, improve body immunity, anti-aging, toxin-expelling and face nourishing, nourishing taste, anti-tired
The work(of labor.Screened the proportioning of each component by great many of experiments, scientific and reasonable；And whole preparation technology is reasonable and medicine recovery rate
Efficiency is high, can retain the active ingredient in raw material well, not bring any impurity, and sweet mouthfeel into, have no side effect.
The invention has the beneficial effects as follows:
1st, the nutrient formulation nano particle of the present invention, promotes the production of body fluid to quench thirst, and promotes gastric acid secretion, helps digest, health body-building, have
Calm nerves is weak, lessens fatigue, and containing various trace elements such as calcium, iron, zinc, selenium, sodium etc., to raising body immunity, resists
Aging, toxin-expelling and face nourishing, nourishing taste, fall three is high, prevent and treat diabetes and anti-cancer, the aspect such as anticancer are all powerful, and regulation human body is raw
Reason function.
2nd, the present invention is rich in anthocyanidin, and human body can be protected from the damage of free radical, can strengthen blood vessel elasticity, relax
Blood vessel, increases systemic blood circulation, has certain blood pressure reduction effect；Immune system ability can be strengthened, there is strong anti-oxidation, resist
Suddenly change, mitigate dyshepatia, protect the functions such as cardiovascular；
3rd, temperature logical dissipates cold, kidney tonifying dehumidifying, acupuncture-stimulating blood stasis dispersing, tune fill blood to add Chinese herbal medicine to have, and can treat cervical spine syndrome, improve
The functions such as body immunity, anti-aging, toxin-expelling and face nourishing, nourishing taste, antifatigue.
4th, the products taste that the production technology of the present invention and preparation method draw is sour-sweet tasty and refreshing, rich in dendrobium polysaccharide, has
Very high health care and medical value, Long-Time Service can with enriching yin beauty treatment, change skin colour, anti-aging, promote longevity, and
Carrying easy to use, improving self increases the wriggling of stomach, cures the disease and strengthens body immunity simultaneously.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, in order to those skilled in the art knows more about
The present invention, but it and is not so limited the present invention.
Embodiment 1
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, described nutrient formulation nano particle is by following raw material: purple potato,
Rice, millet, cornstarch, black rice, Semen sesami nigrum, amino acid, the concentrated liquid of tradition Chinese medicine, vitamin and water are processed in right amount；
Described nutrient formulation nanoparticle raw materials according to weight is: purple potato 8 parts, 2 parts of rice, millet 5 parts, cornstarch
8 parts, black rice 8 parts, Semen sesami nigrum 8 parts, 0.1 part of amino acid, the concentrated liquid of tradition Chinese medicine 5 parts, vitamin 0.1 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: deer's sinew 10 parts, parasitic loranthus 12 parts, Fructus Chaenomelis 8 parts, the seed of jog's tears 15
Part, the fruit of glossy privet 20 parts, the bark of eucommia 10 parts, Radix Codonopsis 8 parts, teasel root 8 parts, the red sage root 10 parts, the root of kudzu vine 12 parts, the radix paeoniae rubrathe 12 parts, Radix Angelicae Sinensis 12 parts, fish
Fish glue 10 parts, the fresh stem of noble dendrobium 15 parts, grape 15 parts, honey, water are appropriate.
The raw material of described amino acid according to weight is: isoleucine 0.02 part, 0.03 part of tyrosine, phenylalanine
0.01 part, lysine 0.01 part, arginine 0.01 part, histidine 0.01 part, tryptophan 0.01 part, citrulling 0.01 part, bird ammonia
Acid 0.01 part, L-Leu 0.01 part, ILE 0.01 part, Valine 0.01 part；
Vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin
B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, whole mixing of biotin
And weight portion is identical.
The preparation processing method of a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, comprises the following steps；
A, the fresh stem of noble dendrobium and grape are cleaned up, the fresh bar of the screening high-quality stem of noble dendrobium and grape, dry standby；
B, the fresh stem of noble dendrobium is put into rotating centrifugal juice extractor and carry out stem of noble dendrobium juice and separate with fiber stand-by；Again grape is put into and blow
In wind continous way quick-freezing plant, the air being-40～-30 DEG C by temperature makes the surface of grape tie according to the speed of 3～6m/s
Ice, then carry out grape meat, Grape Skin, grape pip detached job；By grape pip through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated grape-kernel oil is standby；
C, stem of noble dendrobium juice and grape meat are put into mixing drum Matrix Solution I；
D, the steaming adding the honey being equivalent to dendrobium fiber and Grape Skin gross weight 20-30% and 5-10 times of weight in hermetically sealed can
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, the temperature in holding hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Grape Skin gross weight
Enzyme and the mixing enzyme preparation of protease；Digest 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, and filter residue deionized water is washed；Feed liquid after enzymolysis homogeneous under the super-pressure of 80～140MPa, centrifugation is removed
Insoluble matter, obtains Matrix Solution II；Rich in anthocyanidin in Grape Skin, human body can be protected from the damage of free radical, can strengthen
Blood vessel elasticity, lax blood vessel, increase systemic blood circulation, have certain blood pressure reduction effect；Immune system ability can be strengthened, tool
Having strong anti-oxidation, anti-sudden change, mitigating dyshepatia, protect the functions such as cardiovascular, Grape Skin is stirred together with the stem of noble dendrobium fresh bar fiber
Mix to smash and mention anthocyanidin through hydromel, the quality of anthocyanidin while can farthest extracting anthocyanidin, can be protected.Will
Water-soluble dietary fiber adds Matrix Solution to obtain Matrix Solution II, can increase effect of the wriggling of stomach, it is ensured that metabolic waste
Normally excrete；Adsorbing various metabolic waste, being allowed to normally excrete, the comprehensive utilization value improving the stem of noble dendrobium improves simultaneously
The absorption to traditional Chinese medicine ingredients for the human body.
Thing, obtains Matrix Solution II；
It E, is placed at the bark of eucommia, Radix Codonopsis, teasel root in the distilled water of 40-50 DEG C, soaks 20-30min minute, be heated to 100 DEG C, protect
Hold pressure at the micro-15min that boils of 0.2MPa, more above-mentioned solution is filtered；Filtering solution heats concentration under the conditions of 0.05MPa；Incited somebody to action
Filtering solution, but to less than 50 DEG C, is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85% by filter solution, after 30 minutes, and will
Precipitation solution is filtered by 0.3um filter, precipitation solution obtained above heats under the conditions of 0.04MPa receipts alcohol, obtains Chinese medicine and carry
Take liquid a；
The root of kudzu vine, the radix paeoniae rubrathe, Radix Angelicae Sinensis mix and blend are put into micronizer, and micronizer heating keeps 80 degree of 5-6 minutes of temperature,
Carry out ultramicro grinding and obtain the ultra micro mixing fine powders of 300-400 mesh；
Take deer's sinew, parasitic loranthus, Fructus Chaenomelis, the seed of jog's tears, the fruit of glossy privet, the red sage root, air bladder, mix and add 30-60 DEG C of warm water immersion 10 points
Zhong Hou, puts into reach in freezer ,-10～-20 DEG C of freezing 10-20 minutes, forms freezing medicine block, mixes freezing medicine block and ultra micro
Fine powder adds boiling water extraction 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds
4 times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, enters
Row infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extract a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add grape-kernel oil obtain traditional Chinese drug inspissation
Liquid；
G, purple potato, rice, millet, cornstarch, black rice, Semen sesami nigrum are put into micronizer, obtain particle meal, and pass through
100 DEG C of heating using microwaves sterilize for 15 minutes, particle meal is put into nanometered disposal equipment again and carries out pure physical crushing process
It is crushed to 1-100nm；Particle meal adds amino acid, vitamin, the concentrated liquid of tradition Chinese medicine and auxiliary material to stir and carry out wet method system
Grain, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, runs 10～30 minutes, puts wet granular
It in boiling drier, EAT 45～85 DEG C, is dried 5～30 minutes, obtains particle, control pellet moisture 4.0%～9.0%.
Comparative example 2
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, processing method and other nutritional labelings are with embodiment 1, described
The prescription of the concentrated liquid of tradition Chinese medicine according to weight is: deer's sinew 10 parts, parasitic loranthus 12 parts, Fructus Chaenomelis 8 parts, the seed of jog's tears 15 parts, glossy privet
Son 20 parts, the bark of eucommia 10 parts, Radix Codonopsis 8 parts, teasel root 8 parts, the red sage root 10 parts, the root of kudzu vine 12 parts, the radix paeoniae rubrathe 12 parts, Radix Angelicae Sinensis 12 parts, the fresh stem of noble dendrobium
15 parts, grape 15 parts, honey, water appropriate.Compare without air bladder composition with embodiment 1.
Comparative example 3
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, other nutritional labelings are with embodiment 1, the group of the concentrated liquid of tradition Chinese medicine
Side according to weight is: deer's sinew 10 parts, parasitic loranthus 12 parts, Fructus Chaenomelis 8 parts, the seed of jog's tears 15 parts, the fruit of glossy privet 20 parts, the bark of eucommia 10
Part, Radix Codonopsis 8 parts, teasel root 8 parts, the red sage root 10 parts, the root of kudzu vine 12 parts, the radix paeoniae rubrathe 12 parts, Radix Angelicae Sinensis 12 parts, 10 parts of air bladder.Compare with embodiment 1
Without the fresh stem of noble dendrobium, grape, honey component and the Matrix Solution I being processed into, Matrix Solution II.Preparation for processing is: real
Execute E and G of example 1 procedure of processing.
Comparative example 4
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, compares with embodiment 1 without purple potato, rice, millet, corn
The nutritional labelings such as starch, black rice, Semen sesami nigrum；Other are all same as in Example 1.
Comparative example 5
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, compares without the trace such as amino acid, vitamin with embodiment 1
Element；Other are all same as in Example 1.
Comparative example 6
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, compares with embodiment 1: without purple potato, rice, millet, jade
Nutritional labeling and the trace elements such as amino acid, vitamin such as rice starch, black rice, Semen sesami nigrum；Other are all same as in Example 1.
Comparative example 7
A kind of nutrient formulation nano particle preventing and treating cervical spine syndrome, compares with embodiment 1: except for the difference that, produces traditional Chinese drug inspissation
Liquid, by medicinal material add water direct boiling method prepare.
Clinical trial divides three parts:
(1) animal acute toxicity and chronic toxicity experiment:
1st, animal acute toxicity test
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutrient powder.
Experimental animal: regular grade NIH mouse, body weight 18g ± 2g, male and female half and half.
Method and result:
By each for nutritional granular 50g, adding water, the nutritional granular powder made is stuck with paste.Experiment mice is randomly divided into 7 groups of male and female half and half,
7 kinds of nutritional granular powder of feeding are stuck with paste respectively, volume 1ml/10g body weight, and close observation 8 hours is simultaneously noted down, and continue to observe 7 days；7
In it, mouse is without death, and behavior is active, and food ration is as usual, and hair color light is without loose dirt, without fainting from fear addicted to saliva, eye, mouth, nose, ear and
Crissum secretion without exception, without the rotten toe of docking.Select 2 execution respectively from 7 groups, finding of naked eye: the heart, liver, lung, stomach interior and
The important organs such as thymus gland, no abnormality seen changes, shows two kinds of this nutrient powder all without acute toxicity.
2nd, long-term toxicity test for animals
Medicine: the embodiment of the present invention 1 and remaining comparative example's gained nutritional granular nutritional granular powder made that adds water is stuck with paste.
Animal: regular grade SD rat, body weight 200g ± 10g, male and female half and half.
Method and result:
The configuration that 7 kinds of nutritional granular powder are stuck with paste: be divided into high, medium and low three dosage groups, respectively edible for patients amount the 200th, the 100th,
50g；Experimental mouse is randomly divided into 7 groups, and the nutritional granular powder that continuous feeding modulates respectively is stuck with paste, and continuous feeding 40 days is observed dynamic
Thing general toxic reaction and the order of severity, place after death checks each position by operational procedure, and carry out hematology, ALT, BUN and
The pathological examination of the main organs such as the heart, liver, spleen, lung, kidney, stomach；
Through long-term feeding, all there is not toxic reaction in two groups of rats.Grow good.Macroscopic appearance and main organs have no
Abnormal.Peripheral hemogram and Serum ALT, BUN compare with control group without pathologic change.The pathological replacement heart, liver, spleen, lung, kidney, stomach
Deng all not significant change, it is understood that through proved by pathology, 7 kinds of nutritional granular powder are stuck with paste to animal without chronic toxicity table
Existing.
By two above toxicity test, it was demonstrated that the nutritional granular that the present invention is made by embodiment 1 and comparative example is
Safety, have no side effect, can be used to carry out clinical testing to clinical patients.
3rd, embodiment of the present invention using effect investigation:
(1) investigation method:
1. use crowd: general population
2. the use time: 90 days
3. number of users: 100 people
4. using method: soaked for each person every day 500 mL
5. index: nape pain, upper myasthenia of limbs, finger is numb, lower limb are weak, difficulty in walking, dizziness, Nausea and vomiting, even
Blurred vision, tachycardia and dysphagia, the transference cure such as tired, and mouthfeel are sour-sweet clearly for effective；Above-mentioned clinic after drinking
Remission, and mouthfeel is sour-sweet clearly, is designated as effectively.It is invalid to be then designated as without obvious comfort after drinking.
(2) investigation result
Investigation result is shown in Table 1.
Table 1 each embodiment using effect application form
Conclusion
Be can be seen that by the data of comparative example 2, the ratio of invalid number is compared with embodiment 1, adds 4%, shows air bladder
Serve priming and return through, the function heightening the effect of a treatment in Chinese medicine preparation, improve the assimilation effect to medicine for the human body；Bolus for invigorating kidney and improving,
Kidney has main department and takes the photograph Tibetan, main store essential substances, the function that master grows and reproduction, the liquefaction of main water are thanked.Normal renal function then vital essence fills,
The all dirty negative and positive of whole body are all prosperous；Conversely, as the impact or worn with age of various paathogenic factors, renal function can be caused not normal.Due to fish
Fish glue is a kind of rich sticking material, containing nutritional labelings such as profuse protein, vitamin, mineral matters, so, fish bubble tool
Play the role of kidney tonifying waist knee empty, strong, the beneficial smart and moist beauty treatment of yin-nourishing.For having a delicate constitution, Kidney-Yin loss, psychentonia, fatigue
Excessive personage is most suitable.
The data compared with embodiment 1 by comparative example 3 can be seen that, does not contains the fresh stem of noble dendrobium 15 parts, grape 15 parts, honeybee
Honey composition and the Matrix Solution I being processed into, Matrix Solution II；The ratio of invalid number is compared with embodiment 1, adds 7
Times；And the average time of obvious effective rate, compare many 3 days than embodiment 1 and (i.e. felt effective, the average sky of clinical symptom disappearance
How count 3 days；This shows that the preparation for processing of the present invention makes the concentrated liquid of tradition Chinese medicine prescription and water-soluble dietary fiber and grape pip
Creating mutually collaborative pharmacological action between the compositions such as oil, effect that water-soluble dietary fiber increases the wriggling of stomach promotes people
The absorption to drug ingedient for the body, it is ensured that metabolic waste normally excretes, the anthocyanidin additionally containing in Grape Skin, white black false hellebore
Alcohol, has strong anti-oxidation, anti-sudden change, mitigates dyshepatia, protects the functions such as cardiovascular, strengthens immune system ability；In with
Medicine is associated with raising assimilation effect, improves the mouthfeel of Chinese medicine simultaneously, through the configuration and at utmost drug ingedient meticulously of the present invention
Extraction, traditional Chinese drug inspissation formula of liquid of the present invention and preparation method occur in that beat all technique effect.
Compared with embodiment 1 by the data of comparative example 4 and can be seen that, without purple potato, rice, millet, cornstarch,
The nutritional labeling such as black rice, Semen sesami nigrum, the ratio of invalid number is compared with embodiment 1, adds 10 times, and the number of obvious effective rate
Also reduced, show the nutritional labeling the concentrated liquid of tradition Chinese medicines such as the purple potato of the present invention, rice, millet, cornstarch, black rice, Semen sesami nigrum
Drug effect between create mutually collaborative pharmacological action, the sufficient nutrient of supply human body, dietary structure is reasonably combined,
Nutritional labeling supplements the necessary energy of human body, reaches balanced nutritious, promotes the absorption to medicine for the health.
Compared with embodiment 1 by comparative example 5, the trace element such as amino acid, vitamin；Supplementary needed by human body is wanted
Nutrient and trace element regulation physiological function, catalysis metabolic adsorption medicine during have highly important effect.
The data compared with embodiment 1 by comparative example 6 can be seen that, without purple potato, rice, millet, cornstarch,
The nutritional labeling such as black rice, Semen sesami nigrum and the trace element such as amino acid, vitamin；Inefficiency number nearly 15 times and efficient number
Also nearly 20% is declined；And the average time of obvious effective rate, compare many 10 days than embodiment 1 and (i.e. felt effective people, clinical condition
The average time that shape disappears is many 10 days；Illustrate nutritional labeling and trace element human body medicine absorption during played and
Its important synergy, greatly promotes the absorption to medicine and nutrition for the human body, accelerates human body and recovers.
The data compared with embodiment 1 by comparative example 7 can be seen that, medicinal material adds water direct boiling method and the present invention
Chinese medicine preparation method compare, the preparation method of the present invention, the extraction of drug effect is far longer than traditional adding water and directly boils
Method, the extraction degree of effective component has had huge raising.
In sum, the preparation processing side of a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome that the present invention provides
Method, the pharmacological action that nutritional labeling is mutually worked in coordination with, the sufficient nutrient of supply human body, dietary structure is reasonably combined, and nutrition becomes
Dividing the necessary energy of supplementary human body, reaching balanced nutritious, promote the absorption to medicine for the health, all raw materials are all from medicine-food two-purpose
Natural plants, has no side effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, can also make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (6)
1. the nutrient formulation nano particle preventing and treating cervical spine syndrome, it is characterised in that described nutrient formulation nano particle by
Following raw material: purple potato, rice, millet, cornstarch, black rice, Semen sesami nigrum, amino acid, the concentrated liquid of tradition Chinese medicine, vitamin and water are appropriate
It is processed into；
Described nutrient formulation nanoparticle raw materials according to weight is: purple potato 5-10 part, rice 1-5 part, millet 1-15 part,
Cornstarch 5-10 part, black rice 1-10 part, Semen sesami nigrum 1-10 part, amino acid 0.1-0.5 part, the concentrated liquid of tradition Chinese medicine 2-5 part, vitamin
0.1-0.5 part；
The prescription of described the concentrated liquid of tradition Chinese medicine according to weight is: deer's sinew 5-10 part, parasitic loranthus 10-15 part, Fructus Chaenomelis 5-10
Part, seed of jog's tears 10-26 part, fruit of glossy privet 10-25 part, bark of eucommia 6-15 part, Radix Codonopsis 5-10 part, teasel root 5-10 part, red sage root 10-15 part, Pueraria lobota
Root 10-16 part, radix paeoniae rubrathe 10-16 part, Radix Angelicae Sinensis 10-16 part, air bladder 1-10 part, fresh stem of noble dendrobium 10-20 part, grape 10-20 part, honeybee
Honey, water are appropriate.
2. a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome according to claim 1, it is characterised in that described
The raw material of amino acid according to weight is: isoleucine 0.01-0.08 part, tyrosine 0.01-0.05 part, phenylalanine
0.01-0.04 part, lysine 0.01-0.03 part, arginine 0.01-0.05 part, histidine 0.01-0.07 part, tryptophan 0.01-
0.06 part, citrulling 0.01-0.05 part, ornithine 0.01-0.05 part, L-Leu 0.01 part, ILE 0.01 part, L-
Valine 0.01 part.
3. the preparation processing method of the nutrient formulation nano particle preventing and treating cervical spine syndrome, it is characterised in that include following
Step；
A, the fresh stem of noble dendrobium and grape are cleaned up, the fresh bar of the screening high-quality stem of noble dendrobium and grape, dry standby；
B, the fresh stem of noble dendrobium is put into rotating centrifugal juice extractor and carry out stem of noble dendrobium juice and separate with fiber stand-by；Again grape is put into and blow
In wind continous way quick-freezing plant, the air being-40～-30 DEG C by temperature makes the surface of grape tie according to the speed of 3～6m/s
Ice, then carry out grape meat, Grape Skin, grape pip detached job；By grape pip through vacuum outgas, then use CO2 shooting flow
Body extracts, and the condition of CO2 supercritical fluid extraction is: extracting pressure 45MPa, extraction temperature 35-45 DEG C, extraction time 30min,
Isolated grape-kernel oil is standby；
C, stem of noble dendrobium juice and grape meat are put into mixing drum Matrix Solution I；
D, the steaming adding the honey being equivalent to dendrobium fiber and Grape Skin gross weight 20-30% and 5-10 times of weight in hermetically sealed can
Distilled water, stirring is smashed to 100 mesh, is preserved 24h, sterilizing at 37.5 DEG C～38.9 DEG C lower seals of temperature, filter, put into unglazed sealing
Tank, the temperature in holding hermetically sealed can, at the alphalise starch adding the 0.2%-0.5% being equivalent to dendrobium fiber and Grape Skin gross weight
Enzyme and the mixing enzyme preparation of protease；Digest 60 minutes under the conditions of pH6.5；After feed liquid after enzymolysis filters, filtrate concentrates and removes egg
After white, alcohol is washed, and filter residue deionized water is washed；Feed liquid after enzymolysis homogeneous under the super-pressure of 80～140MPa, centrifugation is removed
Insoluble matter, obtains Matrix Solution II；
It E, is placed at the bark of eucommia, Radix Codonopsis, teasel root in the distilled water of 40-50 DEG C, soaks 20-30min minute, be heated to 100 DEG C, protect
Hold pressure at the micro-15min that boils of 0.2MPa, more above-mentioned solution is filtered；Filtering solution heats concentration under the conditions of 0.05MPa；Incited somebody to action
Filtering solution, but to less than 50 DEG C, is pumped into the Alcohol-settling tank containing the ethanol that mass content is 85% by filter solution, after 30 minutes, and will
Precipitation solution is filtered by 0.3um filter, precipitation solution obtained above heats under the conditions of 0.04MPa receipts alcohol, obtains Chinese medicine and carry
Take liquid a；
The root of kudzu vine, the radix paeoniae rubrathe, Radix Angelicae Sinensis mix and blend are put into micronizer, and micronizer heating keeps 80 degree of 5-6 minutes of temperature,
Carry out ultramicro grinding and obtain the ultra micro mixing fine powders of 300-400 mesh；
Take deer's sinew, parasitic loranthus, Fructus Chaenomelis, the seed of jog's tears, the fruit of glossy privet, the red sage root, air bladder, mix and add 30-60 DEG C of warm water immersion 10 points
Zhong Hou, puts into reach in freezer ,-10～-20 DEG C of freezing 10-20 minutes, forms freezing medicine block, mixes freezing medicine block and ultra micro
Fine powder adds boiling water extraction 3 times, adds 2 times amount water for the first time, and temperature keeps 100-120 DEG C, carries out infusion 20 minutes；Second time adds
4 times amount water, temperature keeps 80-100 DEG C, carries out infusion 10 minutes；Third time adds 2 times amount water, and temperature keeps 120-150 DEG C, enters
Row infusion 30 minutes, filters, and insulation is concentrated into the 1/2 of original volume, adds Chinese medicine extract a, obtains Matrix Solution III standby；
F, by Matrix Solution I, Matrix Solution II, Matrix Solution III hybrid filtering concentrate add grape-kernel oil obtain traditional Chinese drug inspissation
Liquid；
G, the nutritional labelings such as purple potato, rice, millet, cornstarch, black rice, Semen sesami nigrum are put into micronizer, obtain particle thick
Powder, and within 15 minutes, sterilized by 100 DEG C of heating using microwaves, again particle meal is put into nanometered disposal equipment and carry out pure physics
Pulverization process is crushed to 1-100nm；Particle meal adds amino acid, vitamin, the concentrated liquid of tradition Chinese medicine and auxiliary material to stir and carry out
Wet granulation or one-step palletizing preparing granular.
4. the preparation processing method of a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome according to claim 3,
It is characterized in that, described auxiliary material is in dextrin, beta-schardinger dextrin, soluble starch, microcrystalline cellulose, magnesium carbonate or calcium carbonate
Any one.
5. the preparation processing method of a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome according to claim 3,
It is characterized in that, the step of the wet granulation in described step G is as follows: add adhesive to carry out making wet in mixer-granulator
Grain, paddle rotating speed 70～150 revs/min, fly cutter rotating speed 200～800 revs/min, runs 10～30 minutes, puts wet granular
It in boiling drier, EAT 45～85 DEG C, is dried 5～30 minutes, obtains particle, control pellet moisture 4.0%～9.0%.
6. the preparation processing method of a kind of nutrient formulation nano particle preventing and treating cervical spine syndrome according to claim 3,
It is characterized in that, the step of the one-step palletizing in described step G is as follows: control particle temperature, at 50 ± 5 DEG C, is dried, moisture control
System is 4.0%～9.0%.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
| CN104435882A (en) * | 2014-11-25 | 2015-03-25 | 四川金堂海纳生物医药技术研究所 | Traditional Chinese medicine decoction for treating cervical vertebra syndrome and preparation method thereof |
| CN104815215A (en) * | 2015-05-16 | 2015-08-05 | 四川双鑫生物科技有限公司 | Oral medicine for treating cervical spine syndrome and preparation method of oral medicine |
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2016
- 2016-04-17 CN CN201610234252.XA patent/CN106165884A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300450A (en) * | 2013-06-14 | 2013-09-18 | 浙江大学 | Preparation method of raw dendrobium officinale pulp beverage |
| CN104435882A (en) * | 2014-11-25 | 2015-03-25 | 四川金堂海纳生物医药技术研究所 | Traditional Chinese medicine decoction for treating cervical vertebra syndrome and preparation method thereof |
| CN104815215A (en) * | 2015-05-16 | 2015-08-05 | 四川双鑫生物科技有限公司 | Oral medicine for treating cervical spine syndrome and preparation method of oral medicine |
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