CN103110861A - Granular preparation for preventing infants from getting inflamed and adjusting intestines and stomach and preparation method thereof - Google Patents
Granular preparation for preventing infants from getting inflamed and adjusting intestines and stomach and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a granular preparation for preventing infants from getting inflamed and adjusting intestines and stomach and a preparation method thereof. The granular preparation for preventing infants from getting inflamed and adjusting intestines and stomach comprises the following raw materials in parts by weight: 15-30 parts of rhizoma dioscoreae, 2-12 parts of chrysanthemum, 2-12 parts of honeysuckle, 2-12 parts of platycodon grandiflorum, 5-15 parts of cooked coix seeds, 5-25 parts of raw coix seeds, 5-15 parts of corncobs, 1-8 parts of endothelium corneum gigeriae galli, 3-15 parts of medicated leaven, 1-10 parts of radix ophiopogonis, 2-14 parts of roasted malts, 1-8 parts of dried tangerine or orange peels, 1-8 parts of poria cocos, 1-8 parts of fried hawthorns, 0.5-3 parts of xylooligosaccharide, 0.05-0.3 part of bifidobacterium infantis, and 0.05-0.3 part of Lactobacillus acidophilus. According to the invention, through the organic combination of the raw materials, various ingredients with different effects are fused into a product, and the ingredients are mutually cooperated, synergistically act, systemically and completely complement nutrition and regulate the body, thereby achieving the functional effect of preventing infants from getting inflamed and adjusting intestines and stomach.
Description
Technical field
The present invention relates to a kind of prevent to fight on infant have granule of regulating the intestines and stomach effect and preparation method thereof.
Background technology
Although China is publicizing and is advocating the breast feeding of infant always, but, due to many reasons, the pure breastfeeding rate of baby in rear 6 months of current China birth only 30%, a lot of childs adopt breast milk+artificial milk powder to feed, or adopt the method for artificial milk powder+diatery supplement nursing.Thus, often can cause infant belly pain abdomen account, damp and hot constipation, skin sensitivity, agitation to occur and easily cry, sleep unpeaceful etc. and feed caused steam problem because of milk powder, simultaneously, also can be with symptoms such as halitosis, agitation, vomitings.
For this problem, most people adopt pure Chinese medicinal preparation allotment milk powder or bath, drink for infant, feed to lower because of milk powder the intestines and stomach steam that produces, and still, only this adjusting can not achieve the goal mostly; This is mainly or edible breast milk low due to the breast feeding ratio, in the intestinal of infant bacillus bifidus than regular meeting fast reducing, and cause reduction and the imbalance of infant gastrointestinal function.So, for the problems referred to above, be not only and will adopt Chinese medicine to regulate, also should increase prebiotics, improve the ratio of probiotic bacteria in infants, to promote growing up healthy and sound of infant.
Summary of the invention
The invention provides and a kind ofly prevent infant to get angry to regulate granule of the intestines and stomach and preparation method thereof.
Described a kind of granule that prevents infant to get angry to regulate the intestines and stomach, contain the raw material of following weight proportion:
15～30 parts of Rhizoma Dioscoreaes, 2～12 parts of Flos Chrysanthemis, 2～12 parts of Flos Loniceraes, 2～12 parts of Radix Platycodoniss, 5～15 parts of ripe Semen Coiciss, 5～25 parts of raw pearl barleys, 5～15 parts of corn cobs, 1～8 part of Endothelium Corneum Gigeriae Galli, 3～15 parts of Massa Medicata Fermentata, 1～10 part of Radix Ophiopogonis, 2～14 parts of Fructus Hordei Germinatus (parched)s, 1～8 part of Pericarpium Citri Reticulatae, 1～8 part, Poria, 1～8 part of Fructus Crataegi (parched), 0.5～3 part of oligomeric xylose, 0.05～0.3 part of bifidobacteria infantis, 0.05～0.3 part of bacillus acidophilus;
Described prevention infant is got angry and is regulated the granule of the intestines and stomach, preferably contains the raw material of following weight proportion:
18～26 parts of Rhizoma Dioscoreaes, 4～10 parts of Flos Chrysanthemis, 4～10 parts of Flos Loniceraes, 4～10 parts of Radix Platycodoniss, 7～12 parts of ripe Semen Coiciss, 8～20 parts of raw pearl barleys, 8～12 parts of corn cobs, 2～6 parts of Endothelium Corneum Gigeriae Galli, 5～12 parts of Massa Medicata Fermentata, 2～7 parts of Radix Ophiopogonis, 5～12 parts of Fructus Hordei Germinatus (parched)s, 3～6 parts of Pericarpium Citri Reticulataes, 3～8 parts, Poria, 3～6 parts of Fructus Crataegi (parched), 1～2 part of oligomeric xylose, 0.1～0.25 part of bifidobacteria infantis, 0.1～0.25 part of bacillus acidophilus;
Described prevention infant is got angry and is regulated the granule of the intestines and stomach, further preferably contains the raw material of following weight proportion:
20～24 parts of Rhizoma Dioscoreaes, 5～7 parts of Flos Chrysanthemis, 5～7 parts of Flos Loniceraes, 5～7 parts of Radix Platycodoniss, 8～11 parts of ripe Semen Coiciss, 10～15 parts of raw pearl barleys, 9～11 parts of corn cobs, 3～5 parts of Endothelium Corneum Gigeriae Galli, 7～10 parts of Massa Medicata Fermentata, 3～6 parts of Radix Ophiopogonis, 8～10 parts of Fructus Hordei Germinatus (parched)s, 4～5 parts of Pericarpium Citri Reticulataes, 5～7 parts, Poria, 4～5 parts of Fructus Crataegi (parched), 1～2 part of oligomeric xylose, 0.1～0.25 part of bifidobacteria infantis, 0.1～0.25 part of bacillus acidophilus.
Described part is the unit of weights such as g, kg, ton.
Described granule day dose with the adjusting the intestines and stomach effect of fighting on the prevention infant is recommended as, every bag of 2g, every day 2-3 time, 1～2g/ time.
Described prevention infant is got angry and is regulated the granule of the intestines and stomach, and preparation method comprises the following steps:
1) raw material extracts: with Flos Chrysanthemi, and Flos Lonicerae, ripe Semen Coicis, raw pearl barley, corn cob, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Radix Ophiopogonis, Fructus Hordei Germinatus (parched), Pericarpium Citri Reticulatae, Poria, Fructus Crataegi (parched), Radix Platycodonis mixes, then adopt the water of 65 ℃-95 ℃ to carry out 2 times and extract, extract amount of water for the 1st time and be the 5-10 of raw material weight doubly, 3 hours extraction times; Extract amount of water for the 2nd time and be the 3-5 of raw material weight doubly, 2 hours extraction times; 2 extracting solution are merged, adopt 200 orders to filter, then vacuum concentration, making proportion is 1.1-1.35g/cm
3Concentrated solution;
2) Rhizoma Dioscoreae powder preparation: Rhizoma Dioscoreae is pulverized, add the pure water stirring and dissolving of 3～8 times of weight, be heated to 65～85 ℃, gelatinizing (30min), vacuum concentration, spray drying is prepared into Rhizoma Dioscoreae dry powder;
3) granule preparation: concentrated solution and Rhizoma Dioscoreae dry powder blend with above-mentioned preparation, then adopt the conventional drying method, drying is prepared into granule;
4) granule is pulverized: above-mentioned dried particles is pulverized, be prepared into 30～80 purpose granule fine powders;
5) mix: with oligomeric xylose, bifidobacteria infantis, bacillus acidophilus and above-mentioned granule fine powder mix homogeneously, and get final product.
Infants milk powder and diatery supplement feed the reason of getting angry be mainly because, the infant the intestines and stomach is in the stage of development, the functions such as digestion are not yet sound, assimilate and Self-regulation ability a little less than, due to the food not science of arranging in pairs or groups, superfluous nutrient substance is difficult to digestion, causes the production of heat due to retention of food and " getting angry ".In addition, the traditional Chinese medical science is thought: children's is " pure-yang constituent ", and i.e. " getting angry " phenomenon of excess of YANG hyperactivity of fire easily appears in the body constitution partial heat.
So for the reason of infant generation the intestines and stomach steam, the present invention selects to have the health care food materials of strengthening the spleen to promote digestion, promoting diuresis to eliminate damp pathogen targetedly, adjusts and strengthen children's's spleen and stomach function; Select heat-clearing and toxic substances removing health care food materials effectively to dispel pathogenic factor in child's body, but and health invigorating; Simultaneously, be aided with the gastrointestinal function that probiotic bacteria improves children's self.Avoid using merely Chinese herbal medicine and Chinese herbal medicine decoction, do not increase the weight of children's's liver and taste burden, also can not damage children's self human body function.
One, strengthening the spleen to promote digestion
1, Endothelium Corneum Gigeriae Galli: refer to the gizzard inwall of a chicken, these product are that tradition is used for the diseases such as dyspepsia, and effect is splendid, so name with " gold ".The Endothelium Corneum Gigeriae Galli sweet in the mouth, cold in nature.Return spleen, stomach, small intestinal, urinary bladder channel.Has promoting digestion and invigorating the stomach, alleviating distention in middle-JIAO spleen invigorating, the effect of the mill stomach that helps digestion.Control children's's breast food knot stagnant, the large muscle of tripe is blue or green, the mass in the abdomen infantile malnutrition.
2, Massa Medicata Fermentata: for after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixed, the herbal leaven that forms through fermentation.Sweet in the mouth, suffering, warm in nature.Return spleen, stomach warp.Have invigorating the spleen and regulating the stomach, mediation helps digestion.Be used for the eating accumulation card.This product has the merit of promoting digestion and invigorating the stomach and middle antidiarrheal.
3, Fructus Hordei Germinatus: for the mature fruit of grass Fructus Hordei Vulgaris gets through the drying of germinateing.Sweet in the mouth, property is flat.Return spleen, stomach warp, Liver Channel.Promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.Fructus Hordei Germinatus: be longer than stomach invigorating.Fructus Hordei Germinatus (parched): be partial to promote qi circulation digestion promoting.
4, Fructus Crataegi: sweet in the mouth, slightly warm in nature acid.The energy appetite-stimulating indigestion-relieving offsets the meat stagnation effect better especially, has all adopted Fructus Crataegi in a lot of digestant medicines; But the Fructus Crataegi single or with other foods, compatibility of drugs to improve its dietary function.Fructus Crataegi adds the JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) that Fructus Hordei Germinatus, Massa Medicata Fermentata etc. are made, can be used for dyspepsia, retention of food and drink abdominal distention, heating installation, do not think the diseases such as food.Fructus Crataegi adds Endothelium Corneum Gigeriae Galli, invigorating the spleen and regulating the stomach, and removing food stagnancyization is stagnant, children's infantile malnutrition symptom due to being used for stopping in food stagnation, inappetence, abdominal distention, dyspepsia, dysporia.Fructus Crataegi (parched), function of promoting blood circulation to disperse blood clots reduces, and the effect of dyspepsia and intestinal stasis relieving is strengthened.
Two, promoting diuresis to eliminate damp pathogen
1, Semen Coicis: Semen Coicis is long at China's cultivation history, is one of all good grain kind of the ancient medicine food of China.Whole nation most area is all produced, and take provinces such as Fujian, Hebei as main, because the nutritive value of Semen Coicis is very high, is described as " king of world grass " and " standing grain of life and health ".The Semen Coicis slightly sweet flavor, cool in nature.Return spleen, stomach, lung meridian.Function with spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus, eliminating impediment, diuretic.Raw pearl barley is partially cold and cool, is longer than promoting diuresis to eliminate damp pathogen; Ripe Semen Coicis goes its little cool property, and property is partially gentle, is longer than invigorating the spleen to arrest diarrhea, so give birth to ripe Semen Coicis use simultaneously, gets its function and is not afraid of too cold and cool.
2, corn cob: the excellent core after corn rod threshing.Corn cob has identical effect with Stigma Maydis, and simultaneously, because it contains the sugar of 50% left and right, when extracting the juice use, local flavor is better.Property slightly sweet flavor and putting down enters liver, kidney, urinary bladder channel, and the function of inducing diuresis to remove edema, suppressing the hyperactive liver function of gallbladder promoting is arranged.
3, Poria: for colonizing in the fungi plant on pinaster root, ancients claim that Poria is " 4 o'clock god's medicines ", because its effect is very extensive, regardless of the four seasons, with it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects.Poria sweet in the mouth, light, property are flat, GUIXIN warp, lung meridian, spleen channel, kidney channel.Be used as medicine have promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Poria and Rhizoma Dioscoreae, the Fructus Hordei Germinatus collocation infantile dyspepsia that can disappear, anorexia; Have loose bowels with Semen Coicis, the Pericarpium Citri Reticulatae collocation infantile spleen deficiency that can disappear, dysuria; Poria and collocation Radix Ophiopogonis can be used for eliminating insufficiency of heart-YIN, irritable feverish sensation of chest and heart, palpitation with fear insomnia, dry mouth and tougue.
Three, heat-clearing and toxic substances removing
1, Flos Chrysanthemi: be the beverage of China's heat-clearing and toxic substances removing commonly used, the effect of have dispelling wind, heat clearing away, make eye bright, detoxifying.
2, Flos Lonicerae: the good medicine that from ancient times is described as heat-clearing and toxic substances removing.The sweet cold of its property fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Effect with heat-clearing and toxic substances removing, dispelling wind and heat pathogens, thin throat, the relieving restlessness of relieving summer heat.
Four, tonification is promoted the production of body fluid
1, Radix Ophiopogonis: sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.Have YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire, the effect that relieving restlessness is quenched the thirst.Be used for dryness of the lung dry cough, Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, the dryness of the intestine constipation.
2, Radix Platycodonis: bitter in the mouth, suffering, property is flat.Return lung meridian.Have lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, the effect that fills blood, mend five kinds of over strain, foster the spirit of nobility.
3, Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, bitter in the mouth.Enter spleen channel, stomach warp, lung meridian.Have regulating qi-flowing for strengthening spleen, in accent, dampness is reduced phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia.Pericarpium Citri Reticulatae has the three major types effect, and the one, lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three greatly on, Main Function is the row QI of the spleen and stomach.
4, Rhizoma Dioscoreae: Rhizoma Dioscoreae contains the materials such as amylase, polyphenol oxidase, is conducive to the taste digestive and absorptive functions, is the good merchantable brand of the medicine-food two-purpose of flat tonifying the spleen and stomach simply.Rhizoma Dioscoreae, sweet in the mouth, property is flat.Return spleen, lung, kidney channel.The spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.
Five, prebiotics
1, oligomeric xylose: claiming again xylooligosaccharide, is the functional polymerization sugar that is combined into β-Isosorbide-5-Nitrae glycosidic bond by 2-7 xylose molecule.Compare with common people soybean oligo saccharide used, oligofructose, oligomeric isomaltose etc. and have unique advantage, it can optionally promote the proliferation activity of intestinal bifidobacteria.Oligomeric xylose is one of the strongest kind of polymerization sugar apoplexy due to endogenous wind propagation bacillus bifidus function, its effect is nearly 20 times of other polymerization saccharides, be not hydrolyzed the enzyme of oligomeric xylose in human gastrointestinal tract, so it can directly enter large enteral and be preferably bacillus bifidus and utilize, promote bacillus bifidus propagation to produce simultaneously multiple organic acid.Reduce the intestinal pH value, suppress the harmful bacteria growth, probiotic bacteria is bred in a large number at intestinal.
2, bifidobacteria infantis: in human body intestinal canal, bacterial flora is along with people's age increase is changed significantly.Bacillus bifidus namely occurred in intestinal in 3～4 days after baby due, the infant bifidobacteria accounts for 25% of about intestinal bacterium total amount; Along with the increase at age, bacillus bifidus reduces even disappearance gradually, the old man of over-65s, and bifidobacteria reduces to and only accounts for 7.9%, and the Putrefying bacterias such as aerogenesis pod clostridium, escherichia coli roll up; Because the bacillus bifidus goods are able to extensive use at world wide, broad masses have recognized that its importance.Unique protective effect particularly can be provided for the intestinal health of infant, effectively reduce the sickness rate of infant intestinal infection.
Improve bacillus bifidus quantity in vivo two kinds of methods are arranged: " viable bacteria is external takes a tonic or nourishing food to build up one's health " and " viable bacteria proliferation in vivo "." viable bacteria is external takes a tonic or nourishing food to build up one's health " is exactly the oral active bacteria formulation that some bacillus bifiduss are arranged.
3, bacillus acidophilus: have the intestinal microbial population of adjustment balance, suppress the effect of the propagation of intestinal undesirable microorganism.One mentions bacillus bifidus, and much people know, it is the main probiotic bacteria in large intestine; And the bacillus acidophilus not only under one's belt, the main probiotic bacteria in it or human small intestine.Both quantity is huge for this, mutually helps, and by safeguarding whole gastrointestinal microecological balance, plays the effect that promotes health.
The bacillus acidophilus in the whole gastrointestinal tract of human body, " from top to down " microecosystem regulation environment.D score refers in large intestine, they also can the releasing beneficial bacillus bifidus etc. the material of other probiotic bacterias growths, increase large enteral probiotic bacteria quantity, strengthen their vitality.
Preparation method advantage of the present invention is:
1) with Fructus Hordei Germinatus (parched), Fructus Crataegi (parched), Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata is monarch, invigorating the spleen and regulating the stomach, helps digestion and amasss; With Flos Chrysanthemi, Flos Lonicerae is minister, heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Take Radix Ophiopogonis, Radix Platycodonis, Pericarpium Citri Reticulatae, Rhizoma Dioscoreae as assistant, tonification is promoted the production of body fluid, regulating qi-flowing for strengthening spleen; With Semen Coicis, corn cob, Poria for making, inducing diuresis to remove edema, mind tranquilizing and the heart calming.Monarch is mutually auxiliary to multiply each other, and reaches strengthening the spleen to promote digestion, promoting diuresis to eliminate damp pathogen, alleviates and eliminates infant owing to assimilating and weak belly pain abdomen account, damp and hot constipation, skin sensitivity, the agitation that causes of the Self-regulation ability symptom such as unpeaceful of easily crying, sleep.
2) add especially prebiotics, be conducive to improve the intestinal function of infant, improve Self-regulation ability, promote pharmaceutically-active performance.
3) Rhizoma Dioscoreae is one of invention product effective ingredient, and it has the spleen reinforcing nourishing the stomach, and the effect of the lung benefiting that promotes the production of body fluid has good curative effect to baby's dyspepsia, prevention diarrhoea simultaneously.Utilize Rhizoma Dioscoreae as the carrier of other material compositions, and avoid using other food adjuvants, cause the gastrointestinal upset of infant, or the body constitution of infant is caused other adverse influences.
4) effective ingredient in raw material through extracting and decocting, then loads to effective ingredient on the Rhizoma Dioscoreae powder after overcuring, is conducive to instant edible.
5) dried particles is pulverized again, mixed with prebiotics, because the prebiotics consumption is less, can guarantee to be uniformly dispersed, simultaneously, fine powder rushes the molten quick dissolving that more is conducive to, and concentrated medicinal liquid also more can discharge fast and spread in water.
6) preparation method provided by the present invention, because DUISHANYAO has been carried out the gelatinizing processing, so, make product of the present invention not only have quick dissolving, simultaneously, can also directly adopt warm water to take after mixing it with water, edible more convenient.
The present invention incorporates multiple different efficacies composition in product by above raw material is organically combined, and these compositions cooperatively interact, synergism, and system supplements the nutrients all sidedly, conditioning human body, and reaching fights on the prevention infant regulates the functional effect of the intestines and stomach.Product of the present invention can be regulated the infant body, lowers because of milk powder to feed the intestines and stomach steam that produces, and also improves the ratio of probiotic bacteria in infants by increasing prebiotics, improves the infant gastrointestinal function, to promote growing up healthy and sound of infant.
The specific embodiment
Embodiment 1
The prevention infant is got angry and is regulated granule and the preparation method of the intestines and stomach:
1, take the raw material of following weight proportion:
7 parts of Flos Chrysanthemis, 6 parts of Flos Loniceraes, 7 parts of Radix Platycodoniss, 10 parts of ripe Semen Coiciss, 10 parts of raw pearl barleys, 10 parts of corn cobs, 3 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Massa Medicata Fermentata, 5 parts of Radix Ophiopogonis, 8 parts of Fructus Hordei Germinatus (parched)s, 5 parts of Pericarpium Citri Reticulataes, 5 parts, Poria, 5 parts of Fructus Crataegi (parched).
2, above-mentioned raw materials is adopted the water of 65 ℃-95 ℃ carry out 2 times and extract, extract amount of water for the 1st time and be raw material weight 8 times, 3 hours extraction times; Extract amount of water for the 2nd time and be raw material weight 4 times, 2 hours extraction times; 2 extracting solution are merged, adopt 200 orders to filter, then vacuum concentration, making proportion is 1.2g/cm
3Concentrated solution.
3, with 20 parts of pulverizing of Rhizoma Dioscoreae, add the pure water of 5 times of weight to dissolve, under agitation be heated to 75 ℃ ± 5 ℃, keep 30min, make Rhizoma Dioscoreae dry powder after then concentrated, spray-dried.
4, take the Rhizoma Dioscoreae dry powder that step 3 is made, add the prepared concentrated solution of step 2 under stirring condition, make according to a conventional method dried particles.
5, dried particles is pulverized, crossed 60 mesh sieves, then with 1.5 parts of oligomeric xyloses, 0.2 part of bifidobacteria infantis, 0.2 part of mixing of bacillus acidophilus after mix homogeneously, according to the packaged of 2g/ bag, is the prevention infant and gets angry and regulate the granule finished product of the intestines and stomach.
Embodiment 2
The prevention infant is got angry and is regulated granule and the preparation method of the intestines and stomach:
1, take the raw material of following weight proportion:
4 parts of Flos Chrysanthemis, 4 parts of Flos Loniceraes, 4 parts of Radix Platycodoniss, 7 parts of ripe Semen Coiciss, 8 parts of raw pearl barleys, 8 parts of corn cobs, 2 parts of Endothelium Corneum Gigeriae Galli, 5 parts of Massa Medicata Fermentata, 2 parts of Radix Ophiopogonis, 5 parts of Fructus Hordei Germinatus (parched)s, 3 parts of Pericarpium Citri Reticulataes, 3 parts, Poria, 3 parts of Fructus Crataegi (parched).
2, above-mentioned raw materials is adopted the water of 65 ℃-95 ℃ carry out 2 times and extract, extract amount of water for the 1st time and be raw material weight 5 times, 3 hours extraction times; Extract amount of water for the 2nd time and be raw material weight 3 times, 2 hours extraction times; 2 extracting solution are merged, adopt 200 orders to filter, then vacuum concentration, making proportion is 1.3g/cm
3Concentrated solution.
3, with 18 parts of pulverizing of Rhizoma Dioscoreae, dissolve with the pure water of 4 times of weight, under agitation be heated to 75 ℃ ± 5 ℃, kept 30 minutes, then, make Rhizoma Dioscoreae dry powder after concentrated, spray-dried.
4, take the Rhizoma Dioscoreae dry powder that step 3 is made, add the prepared concentrated solution of step 2 under stirring condition, make according to a conventional method dried particles.
5, dried particles is pulverized, crossed 60 mesh sieves, then with 1 part of oligomeric xylose, 0.1 part of bifidobacteria infantis, 0.1 part of mixing of bacillus acidophilus after mix homogeneously, according to the packaged of 2g/ bag, is the prevention infant and gets angry and regulate the granule finished product of the intestines and stomach.
Embodiment 3
The prevention infant is got angry and is regulated granule and the preparation method of the intestines and stomach:
1, take the raw material of following weight proportion:
10 parts of Flos Chrysanthemis, 10 parts of Flos Loniceraes, 10 parts of Radix Platycodoniss, 12 parts of ripe Semen Coiciss, 20 parts of raw pearl barleys, 12 parts of corn cobs, 6 parts of Endothelium Corneum Gigeriae Galli, 12 parts of Massa Medicata Fermentata, 7 parts of Radix Ophiopogonis, 12 parts of Fructus Hordei Germinatus (parched)s, 6 parts of Pericarpium Citri Reticulataes, 8 parts, Poria, 6 parts of Fructus Crataegi (parched).
2, above-mentioned raw materials is adopted the water of 65 ℃-95 ℃ carry out 2 times and extract, extract amount of water for the 1st time and be raw material weight 10 times, 3 hours extraction times; Extract amount of water for the 2nd time and be raw material weight 5 times, 2 hours extraction times; 2 extracting solution are merged, adopt 200 orders to filter, then vacuum concentration, making proportion is 1.15g/cm
3Concentrated solution.
3, with 26 parts of pulverizing of Rhizoma Dioscoreae, dissolve with the pure water of 7 times of weight, under agitation be heated to 75 ℃ ± 5 ℃, keep 30min, make Rhizoma Dioscoreae dry powder after then concentrated, spray-dried.
4, take the Rhizoma Dioscoreae dry powder that step 3 is made, add the prepared concentrated solution of step 2 under stirring condition, make according to a conventional method dried particles.
5, dried particles is pulverized, crossed 60 mesh sieves, then with 2 parts of oligomeric xyloses, 0.25 part of bifidobacteria infantis, 0.25 part of mixing of bacillus acidophilus after mix homogeneously, according to the packaged of 2g/ bag, is the prevention infant and gets angry and regulate the granule finished product of the intestines and stomach.
Embodiment 4
The get angry granule of regulating the intestines and stomach of prevention infant contains the raw material of following weight proportion:
20 parts of Rhizoma Dioscoreaes, 7 parts of Flos Chrysanthemis, 6 parts of Flos Loniceraes, 7 parts of Radix Platycodoniss, 10 parts of ripe Semen Coiciss, 10 parts of raw pearl barleys, 10 parts of corn cobs, 3 parts of Endothelium Corneum Gigeriae Galli, 10 parts of Massa Medicata Fermentata, 5 parts of Radix Ophiopogonis, 8 parts of Fructus Hordei Germinatus (parched)s, 5 parts of Pericarpium Citri Reticulataes, 5 parts, Poria, 5 parts of Fructus Crataegi (parched), 1.5 parts of oligomeric xyloses, 0.2 part of bifidobacteria infantis, 0.2 part of bacillus acidophilus.
Preparation method is with embodiment 1.
Product crowd test-meal effect observation test of the present invention
(test specimen is the granule of embodiment 1 preparation)
1, crowd's screening: choose 50 effect tests that participate in product of the present invention of infant of 3-12 month, wherein, 32 of male's infant, 18 of women's infant.Participating in the experiment has in infant the 30 auxiliary milk powder of breast milks by name to feed, and feeds with the auxiliary meal food of milk powder for 20.
2, eating method:
1) 6 months Infants Belows, each half bag (approximately 1 gram) every day 2-3 time, drunk with place of water after the warm water dissolving, or is used for rushing molten milk powder, feeding.
2) infant more than 6 months, each 1 bag (2 gram) drunk with place of water after the warm water dissolving, or be used for rushing molten milk powder and other accesary foods, feeding every day 2-3 time.
3, result is observed:
1) damp and hot constipation: June Infants Below 5 people, be the auxiliary milk powder of breast milk and feed, after taking continuously 5 days, effective 3 people, effective percentage 60%; June above infant 15 people, wherein, the auxiliary milk powder of breast milk is fed 9 people, the auxiliary meal food of milk powder is fed 6 people, took continuously 5 days, it is 7 people (effective percentage is 77.8%) that the auxiliary milk powder of breast milk is fed efficiently individual quantity, and it is 5 people (effective percentage is 83.3%) that the auxiliary meal food of milk powder is fed efficiently individual quantity, amounting to efficiently individual quantity is 12 people, and average effectiveness level is 80%.
2) agitation is easily cried, sleeps unpeaceful: June Infants Below 10 people, wherein 7 people feed for the auxiliary milk powder of breast milk, 3 people feed for the auxiliary meal food of milk powder, after taking continuously 5 days, it is 2 people (effective percentage is 28.6%) that the auxiliary milk powder of breast milk is fed efficiently individual quantity, the auxiliary meal food of milk powder is fed 3 people all effective (effective percentage is 100%), and amounting to efficiently individual quantity is 5 people, and average effectiveness level is 50%;
June above infant 20 people, wherein 12 people feed for the auxiliary milk powder of breast milk, 8 people feed for the auxiliary meal food of milk powder, took continuously 5 days, it is 8 people (effective percentage is 66.7%) that the auxiliary milk powder of breast milk is fed efficiently individual quantity, it is 7 people (effective percentage is 87.5%) that the auxiliary meal food of milk powder is fed efficiently individual quantity, amounts to effective 15 people, and average effectiveness level is 75%.
Above-mentioned result of the test explanation, the present invention is for adopting the auxiliary milk powder of breast milk to feed, or the infant that adopts the auxiliary meal food of milk powder to feed the belly pain abdomen account, damp and hot constipation, the agitation that the occur problem such as unpeaceful of easily crying, sleep all has significant alleviation and health care preventive effect.
Claims (4)
1. granule that prevents infant to get angry to regulate the intestines and stomach, contain the raw material of following weight proportion:
15～30 parts of Rhizoma Dioscoreaes, 2～12 parts of Flos Chrysanthemis, 2～12 parts of Flos Loniceraes, 2～12 parts of Radix Platycodoniss, 5～15 parts of ripe Semen Coiciss, 5～25 parts of raw pearl barleys, 5～15 parts of corn cobs, 1～8 part of Endothelium Corneum Gigeriae Galli, 3～15 parts of Massa Medicata Fermentata, 1～10 part of Radix Ophiopogonis, 2～14 parts of Fructus Hordei Germinatus (parched)s, 1～8 part of Pericarpium Citri Reticulatae, 1～8 part, Poria, 1～8 part of Fructus Crataegi (parched), 0.5～3 part of oligomeric xylose, 0.05～0.3 part of bifidobacteria infantis, 0.05～0.3 part of bacillus acidophilus.
2. prevent according to claim 1 infant to get angry and regulate the granule of the intestines and stomach, preferably contain the raw material of following weight proportion:
18～26 parts of Rhizoma Dioscoreaes, 4～10 parts of Flos Chrysanthemis, 4～10 parts of Flos Loniceraes, 4～10 parts of Radix Platycodoniss, 7～12 parts of ripe Semen Coiciss, 8～20 parts of raw pearl barleys, 8～12 parts of corn cobs, 2～6 parts of Endothelium Corneum Gigeriae Galli, 5～12 parts of Massa Medicata Fermentata, 2～7 parts of Radix Ophiopogonis, 5～12 parts of Fructus Hordei Germinatus (parched)s, 3～6 parts of Pericarpium Citri Reticulataes, 3～8 parts, Poria, 3～6 parts of Fructus Crataegi (parched), 1～2 part of oligomeric xylose, 0.1～0.25 part of bifidobacteria infantis, 0.1～0.25 part of bacillus acidophilus.
3. prevent according to claim 1 infant to get angry and regulate the granule of the intestines and stomach, further preferably contain the raw material of following weight proportion:
20～24 parts of Rhizoma Dioscoreaes, 5～7 parts of Flos Chrysanthemis, 5～7 parts of Flos Loniceraes, 5～7 parts of Radix Platycodoniss, 8～11 parts of ripe Semen Coiciss, 10～15 parts of raw pearl barleys, 9～11 parts of corn cobs, 3～5 parts of Endothelium Corneum Gigeriae Galli, 7～10 parts of Massa Medicata Fermentata, 3～6 parts of Radix Ophiopogonis, 8～10 parts of Fructus Hordei Germinatus (parched)s, 4～5 parts of Pericarpium Citri Reticulataes, 5～7 parts, Poria, 4～5 parts of Fructus Crataegi (parched), 1～2 part of oligomeric xylose, 0.1～0.25 part of bifidobacteria infantis, 0.1～0.25 part of bacillus acidophilus.
4. according to claim 1-3 arbitrary described prevention infant are got angry and are regulated the granule of the intestines and stomach, and preparation method comprises the following steps:
1) raw material extracts: with Flos Chrysanthemi, and Flos Lonicerae, ripe Semen Coicis, raw pearl barley, corn cob, Endothelium Corneum Gigeriae Galli, Massa Medicata Fermentata, Radix Ophiopogonis, Fructus Hordei Germinatus (parched), Pericarpium Citri Reticulatae, Poria, Fructus Crataegi (parched), Radix Platycodonis mixes, then adopt the water of 65 ℃-95 ℃ to carry out 2 times and extract, extract amount of water for the 1st time and be the 5-10 of raw material weight doubly, 3 hours extraction times; Extract amount of water for the 2nd time and be the 3-5 of raw material weight doubly, 2 hours extraction times; 2 extracting solution are merged, adopt 200 orders to filter, then vacuum concentration, making proportion is 1.1-1.35g/cm
3Concentrated solution;
2) Rhizoma Dioscoreae powder preparation: Rhizoma Dioscoreae is pulverized, add the pure water stirring and dissolving of 3～8 times of weight, be heated to 65～85 ℃, gelatinizing (30min), vacuum concentration, spray drying is prepared into Rhizoma Dioscoreae dry powder;
3) granule preparation: concentrated solution and Rhizoma Dioscoreae dry powder blend with above-mentioned preparation, then adopt the conventional drying method, drying is prepared into granule;
4) granule is pulverized: above-mentioned dried particles is pulverized, be prepared into 30～80 purpose granule fine powders;
5) mix: with oligomeric xylose, bifidobacteria infantis, bacillus acidophilus and above-mentioned granule fine powder mix homogeneously, and get final product.
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| CN103404849A (en) * | 2013-07-08 | 2013-11-27 | 黄裕兵 | Internal-heat-removing chrysanthemum tea |
| CN104996865A (en) * | 2015-08-25 | 2015-10-28 | 吴燕玲 | Factor nutrition food agent with efficacies of clearing away fire and stimulating appetite and making method of factor nutrition food agent |
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| CN103404849A (en) * | 2013-07-08 | 2013-11-27 | 黄裕兵 | Internal-heat-removing chrysanthemum tea |
| CN106465828A (en) * | 2015-08-14 | 2017-03-01 | 汕头市培芝食品有限公司 | Infant draft pathogenic fire reducing electuary and preparation method thereof |
| CN104996865A (en) * | 2015-08-25 | 2015-10-28 | 吴燕玲 | Factor nutrition food agent with efficacies of clearing away fire and stimulating appetite and making method of factor nutrition food agent |
| CN105124357A (en) * | 2015-10-27 | 2015-12-09 | 江西美庐乳业集团有限公司 | Nutrition bag capable of regulating intestinal microecological environment and relieving internal heat of baby |
| CN105410584A (en) * | 2015-11-30 | 2016-03-23 | 深圳市味奇生物科技有限公司 | Qing Huo Ling plant solid beverage and preparation method thereof |
| CN109045198A (en) * | 2018-09-03 | 2018-12-21 | 张振彬 | A kind of Chinese herbal medicine health preserving powder |
| CN109479972A (en) * | 2018-12-10 | 2019-03-19 | 石家庄君乐宝乳业有限公司 | Improve the baby milk powder companion and preparation method thereof of gastrointestinal tract |
| CN110122874A (en) * | 2019-06-11 | 2019-08-16 | 深圳保时健生物工程有限公司 | A kind of infant is relieved inflammation or internal heat composition |
| CN113273696A (en) * | 2021-05-26 | 2021-08-20 | 郑州大学第二附属医院 | Preparation for promoting intestinal digestion and peristalsis of infants and preventing flatulence |
| CN115634247A (en) * | 2022-08-23 | 2023-01-24 | 南京中山制药有限公司 | Preparation method of stomach medicine granules for invigorating spleen to promote digestion of children |
| CN116172965A (en) * | 2022-09-19 | 2023-05-30 | 沈阳药科大学 | Preparation method and application of charred triplet formula particles |
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