CN102349963B - Health care product for preventing microthrombus from forming and preparation method thereof - Google Patents
Health care product for preventing microthrombus from forming and preparation method thereof Download PDFInfo
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- CN102349963B CN102349963B CN2011103223008A CN201110322300A CN102349963B CN 102349963 B CN102349963 B CN 102349963B CN 2011103223008 A CN2011103223008 A CN 2011103223008A CN 201110322300 A CN201110322300 A CN 201110322300A CN 102349963 B CN102349963 B CN 102349963B
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Abstract
The invention relates to a heath care product for preventing microthrombus from forming and a preparation method thereof. The health care product comprises the following components in part by weight: 1-3 parts of natto powder, 0.8-3 parts of grape skin extract, 8-25 parts of hawthorn powder and 3-15 parts of pomegranate powder. The health care product provided by the invention is rich in various biological active substances, such as natto kinase, resveratrol, flavone, various vitamins and minerals and the like; the biological active substances are scientifically matched to exert cooperative and synergistic action, block off different paths of forming the microthrombus and establish a defensive line for preventing cardiovascular and cerebrovascular diseases.
Description
Technical field
The present invention relates to food and health product or drug world, be specifically related to a kind of health product that prevent microthrombusis and preparation method thereof.
Background technology
Thrombosis (thrombus) is that blood flow is at the surperficial formed fritter of the inner face exfoliation of cardiovascular system blood vessel or mend.In variable fluid dependent form (variable flow dependentpatterns), thrombosis is by insoluble fibrin, the platelet of deposition, and the leukocyte that gathers and the erythrocyte that is absorbed in form.Thrombosis is a kind of process that relates to the multifactor variation of many h and E factors interact with each other.Common patient to thrombosis quality clinically, topmost characteristics are that family history is arranged, repeated relapsing, youth, the seriousness of outbreak symptom and thrombosis position unusual.
The antithrombotic therapy is to use thrombolytic drug, antiplatelet drug and anticoagulant.When formulating antithrombotic therapeutic strategy, at first it is also noted that thrombolytic drug therapy, because thrombolytic drug can be removed an established thrombosis.Antithrombotic treatment is wanted variation, and this depends on that the position of getting involved is vein or arterial circulation system; The degree that blood vessel is got involved and position; Thrombotic expansion, the danger of thromboembolism or recurrence; And antithrombotic treatment and hemorrhage relative pros and cons.The old people vessel aging, blood vessel wall is impaired, easily suffers from hypertension, arteriosclerosis, diabetes.After vascular endothelial cell was impaired, the thromboplastin of generation increased, and promoted thrombin to form, and blood coagulation flavin A2 also increases, and made simultaneously the anticoagulant substances prostacyclin and reduced, and easily brought out thrombosis.When increasing as blood glucose, the hemoglobin of sugar in erythrocyte is combined, and makes body tissue's anoxia, at this moment platelet aggregation enhancing, and viscosity increases, and easily promotes thrombosis.Motion and dietary adjustments can increase high density lipoprotein.Also can often eat a little Bulbus Allii Cepaes, Bulbus Allii, Fructus Capsici, Semen Phaseoli Vulgaris, Herba Spinaciae, Fructus Cucumidis sativi, Radix Dauci Sativae, Fructus Mali pumilae, Fructus Vitis viniferae etc.
Natto is a kind of China's Semen Sojae Preparatum fermented food that is similar to.Natto has very high nutritive value, its protein, fiber, calcium, ferrum, vitamin B
2, vitamin B
3The content of (or vitamin PP), vitamin E is all higher than the Semen sojae atricolor of boiling, particularly vitamin B
2Content be 6 times of steaming and decocting Semen sojae atricolor, the content of the Multiple components such as fiber, calcium, ferrum surpasses egg, but it does not contain vitamin A, vitamin C and cholesterol.At present, the health promoting product take natto as raw material on market is existing multiple, but exists uncertain therapeutic efficacy fixed, and taste is not good enough or use a large amount of correctivess seriously to cover the defective of the original taste of natto.
The main component of Fructus Crataegi is Flavonoid substances, and cardiovascular system is had obvious pharmacological action.At present, the flavone component that separates from Fructus Crataegi has more than 30 to plant, and mainly contains flavonoid glycoside, flavonol and the glycoside thereof, dioxygen flavonoid glycoside, the polymerization flavonoid that contain carbon bond.The composition of another kind of outbalance is triterpene substance, heart tonifying is arranged, increase coronary blood flow, improves the important function such as blood circulation.In addition, contain organic acid such as chlorogenic acid, caffeic acid and tannin, the acid anhydride of tanning, epicatechol, choline, acetylcholine, cupreol, carotene and vitamin C etc. in Fructus Crataegi.
As the saying goes that eating Fructus Vitis viniferae does not tell Pericarpium Vitis viniferae, the Pericarpium Vitis viniferae enlightenment has a lot of medical values, and Pericarpium Vitis viniferae contains than resveratrol abundanter in Fructus Vitis viniferae meat and seed, has the effects such as blood fat reducing, antithrombotic, prevention of arterial sclerosis, enhancing immunity.The Flavonoid substances in the purple grape skin particularly, the effect that reduces blood pressure in addition.Pericarpium Vitis viniferae also contains abundant cellulose, pectic substance and ferrum etc.
Sucus Granati, according to nutritionist research, Sucus Granati almost contains all various natural anti-oxidation compositions, as aldehydes matter, carotenoid (as " lycopene " etc.) and natural complex C etc.Studies show that all over the world in recent years, Punica granatum L. contains very abundant polyphenoils, and very strong protection cardiovascular is arranged, and the prevention of arterial sclerosis reduces the effect of cholesterol, head and shoulders above the effect of red wine.
The research of blood fat reducing Yikang capsules (the master thesis 2005.11.22 of Medical College delivers) disclose by Semen Glycines after fermenting bacillus natto in the refining natto powder that obtains and Folium Crataegi the Fructus Crataegi total flavones of extract coordinate again suitable adjuvant to make.
Do not see the report of the use in conjunction of natto, Fructus Crataegi powder, Pericarpium Vitis viniferae extract, Punica granatum L. powder.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, provide a kind of quality controllable, can give full play to curative effect, the health product that taste is easy to accept.
Another object of the present invention provides the preparation method of these health product.
Another object of the present invention is to provide the application of these health product.
A kind of health product that prevent microthrombusis provided by the invention contain the active component of following weight portion: natto powder 1-3 part, Pericarpium Vitis viniferae extract 0.8-3 part, Fructus Crataegi powder 8-25 part, Punica granatum L. powder 3-15 part.
Preferably, the raw material that contains following weight portion in health product provided by the invention: natto powder 1.5-2.5 part, Pericarpium Vitis viniferae extract 1-2 part, Fructus Crataegi powder 15-20 part, Punica granatum L. powder 5-10 part.
Further preferably, these health product contain the raw material of following weight portion: 1.6 parts of natto powders, 1.4 parts of Pericarpium Vitis viniferae extract, 17.50 parts of Fructus Crataegi powder, 7.50 parts, Punica granatum L. powder.
In compositions provided by the invention:
Described natto powder can adopt commercially available acquisition, also can prepare by following conventional method: after the steaming and decocting of Semen Glycines water, and the inoculation fermenting bacillus natto, drying is pulverized, and be get final product.
Described Pericarpium Vitis viniferae extract can adopt commercially available acquisition, also can extract by conventional method, is preferably: Pericarpium Vitis viniferae can or be used alcohol extraction with water extraction, and wherein Resveratrol content is 2%-5%.
Described Fructus Crataegi powder can adopt commercially available acquisition, and also can prepare by following conventional method: the Fructus Crataegi pulp for preparing after enucleation, spray drying makes.
Described Punica granatum L. powder can adopt commercially available acquisition, and also can prepare by following conventional method: Punica granatum L. is squeezed the juice, and drying makes;
Also contain adjuvant in health product provided by the invention, be selected from one or more in hydroxyl isomaltulose, Sorbitol, magnesium stearate or coating powder.
The composition of the following weight portion of Optimization of Adjuvant: one or more in hydroxyl isomaltulose 25-80, lactose 10-35, Sorbitol 10-35 or magnesium stearate 0.5-2.
The invention provides the method for the health product of preparation prevention microthrombusis, comprise the following steps: with the supplementary material mix homogeneously, tabletting, and get final product.
Preferably, in method provided by the invention, also comprise coating, specifically comprise the following steps: with appropriate transparent coating powder, add appropriate water, stirring and dissolving, coating.
The present invention also provides above-mentioned health product to prevent the health product of microthrombusis and the application in medicine in preparation.
The present invention prevents the health product of microthrombusis can increase or reduce according to corresponding ratio when producing, can be with kilogram or take ton as unit as large-scale production, small-scale production also can be in grams, weight can increase or reduce, but the raw material weight proportioning constant rate between each composition.
The present invention prevents the health product of microthrombusis or pharmaceutical composition to have following advantage:
1, use the former powder of natural fruit that is rich in multiple nutritional components, do not contain any antiseptic, synthetic dyestuff, compound essence, synthetic sweetener.
2, be rich in various bioactivators, nattokinase, resveratrol, Fructus Crataegi flavone, various vitamin and mineral etc., science collocation, Synergistic has been blocked the different approaches of microthrombusis, sets up the defence line of prevention cardiovascular and cerebrovascular disease.
3, the present invention is easy to carry, and the buccal mouthfeel is good.
4, the frame structure of Chinese medicine " monarch, minister, help, make " is adopted in formula for a product design; Wherein natto is monarch (dissolving microthrombus), from three kinds of thrombosed main matrix fibrins of approach dissolving; Fructus Crataegi is minister (blood circulation promoting and blood stasis dispelling), and the effect of getting its blood circulation promoting and blood stasis dispelling is removed blood rubbish; Pericarpium Vitis viniferae extract thing is assistant (antioxidation), gets the effect of its stronger non-oxidizability, blocks thrombotic factor; Punica granatum L. is got the effect of its vessel softening, protection blood vessel for making (protection), prevents thrombosed factor.
5, Fructus Crataegi powder is with after the Fructus Crataegi enucleation, makes to starch that spray drying obtains again, and is rich in various flavone and organic acid, after share with natto powder, Pericarpium Vitis viniferae extract, Punica granatum L. powder, has the effect of Synergistic.
6, adopt direct compression technique in the present invention, do not need heating process, keep to greatest extent active component content in raw material, save simultaneously the water, electricity and gas loss of pelletization, energy savings meets the low-carbon (LC) design.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Raw material in the present invention available from:
Embodiment 1: the tablet of prevention microthrombusis
1, form: natto powder 1kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 0.8kg, Fructus Crataegi powder 8kg, Punica granatum L. powder 3kg, hydroxyl isomaltulose 25kg, Sorbitol 10kg, magnesium stearate 0.5kg;
2, preparation method: with the raw material mix homogeneously of above-mentioned weight proportion, tabletting, and get final product.
Embodiment 2: the tablet of prevention microthrombusis
1, form: natto powder 3kg, Pericarpium Vitis viniferae extract (containing resveratrol 2%) 3kg, Fructus Crataegi powder 25kg, Punica granatum L. powder 15kg, hydroxyl isomaltulose 80kg, Sorbitol 35kg, magnesium stearate 2kg;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 3: the tablet of prevention microthrombusis
1, form: natto powder 3kg, Pericarpium Vitis viniferae extract (containing resveratrol 3%) 0.8kg, Fructus Crataegi powder 8kg, Punica granatum L. powder 15kg, hydroxyl isomaltulose 80kg, lactose 10kg, magnesium stearate 2kg;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 4: the tablet of prevention microthrombusis
1, form: get natto powder 1kg, Pericarpium Vitis viniferae extract (containing resveratrol 4%) 3kg, Fructus Crataegi powder 25kg, Punica granatum L. powder 3kg, hydroxyl isomaltulose 25kg, Sorbitol 35kg, magnesium stearate 0.5kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 5: the tablet of prevention microthrombusis
1, form: get natto powder 1.2kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1kg, Fructus Crataegi powder 15kg, Punica granatum L. powder 5kg, hydroxyl isomaltulose 70kg, Sorbitol 20kg, magnesium stearate 1.5kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 6: the tablet of prevention microthrombusis
1, form: get natto powder 1.5kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1kg, Fructus Crataegi powder 15kg, Punica granatum L. powder 5kg, hydroxyl isomaltulose 30kg, lactose 15kg, magnesium stearate 0.8kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, carry out tabletting on Highspeedrotarytabletpress, and get final product.
Embodiment 7: the tablet of prevention microthrombusis
1, form: get natto powder 2.5kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 2kg, Fructus Crataegi powder 20kg, Punica granatum L. powder 10kg, hydroxyl isomaltulose 60kg, Sorbitol 25kg, magnesium stearate 1.5kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, carry out tabletting on Highspeedrotarytabletpress, and get final product.
Embodiment 8: the tablet of prevention microthrombusis
1, form: get natto powder 2.5kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1kg, Fructus Crataegi powder 20kg, Punica granatum L. powder 5kg, hydroxyl isomaltulose 60kg, Sorbitol 15kg, magnesium stearate 1.2kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 9: the tablet of prevention microthrombusis
1, form: get natto powder 2kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1.5kg, Fructus Crataegi powder 16kg, Punica granatum L. powder 8kg, hydroxyl isomaltulose 40kg, Sorbitol 20kg, magnesium stearate 1.3kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting, and get final product.
Embodiment 10: the tablet of prevention microthrombusis
1, form: get natto powder 1.56kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1.38kg, Fructus Crataegi powder 17.50kg, Punica granatum L. powder 7.50kg, hydroxyl isomaltulose 50.00kg, Sorbitol 21.00kg, magnesium stearate 1.00kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting is removed powder on sheet with chalk dust removal machine after tabletting; Use appropriate film coating agent, add appropriate water, stirring and dissolving, coating, and get final product.
Embodiment 11: the tablet of prevention microthrombusis
1, form: get natto powder 1.6kg, Pericarpium Vitis viniferae extract (containing resveratrol 5%) 1.4kg, Fructus Crataegi powder 17.50kg, Punica granatum L. powder 7.50kg, hydroxyl isomaltulose 36.50kg, lactose 35.00kg, magnesium stearate 0.50kg, standby;
2, preparation method: take above-mentioned supplementary material, then according to the equivalent method mix homogeneously that progressively increases, tabletting is removed powder on sheet with chalk dust removal machine after tabletting; Use appropriate film coating agent, add appropriate water, stirring and dissolving, coating, and get final product.
In order to prove beneficial effect of the present invention, the compositions that the below adopts embodiment 11 to prepare is carried out the experiment of rat thrombus in vivo, antioxidation experiment, with prevention microthrombus and the antioxidative effect of the explanation present composition.Understand for the ease of clear, the following compositions for preparing according to embodiment 11 is referred to as " natto of radically reforming ".
Experimental example 1: to the effect of rat thrombus in vivo
1, experiment material
1.1 experimental drug: the natto of radically reforming (according to composition and the method preparation of embodiment 11,0.8g/ sheet); Aspirin is available from promise pharmaceutcal corporation, Ltd in the stone medicine group of Shijiazhuang; Carrageenin is examined and determine institute available from Products in China; Blood fat reducing benefit health: add 95% alcohol reflux in natto powder 1.56kg, Folium Crataegi 3 times, 2h/ time, merge ethanol extract, be recycled to without the alcohol flavor, add 10 times of water gagings and stir cold preservation placement 24h, cross macroporous resin column, do eluent with ethanol, merge ethanol elution, reclaim under reduced pressure is to liver, namely getting total flavones, is 60-80: 25-45 according to the weight part ratio of natto powder and Folium Crataegi extract, and the ratio of getting 70: 35 is mixed natto powder and Folium Crataegi extract.
1.2 laboratory animal: the wistar rat is available from Beijing dimension tonneau China company limited, the quality certification number: SCXK (capital) 2007-0001, and male.
1.3 experimental apparatus: ACL coagulo meter;
1.4 experiment reagent: TT (thrombin time of blood plasma mensuration test kit), PT (serum PT in patients test kit), APTT (activated partial prothrombin time determination reagent box), FIB (fibrinogen assay test kit) reagent are available from Shanghai sun biotechnology company.
2, experimental technique
2.1 grouping and gavage: 90 rats are divided into 10 groups at random: negative control group, model control group, the aspirin group, the natto low dose group of radically reforming (abbreviation low dosage), the dosage group (dosage in abbreviation) in natto of radically reforming, the natto high dose group of radically reforming (abbreviation high dose), blood fat reducing benefit health group, Pericarpium Vitis viniferae extract group, Punica granatum L. group.
Every group of 10 rats.Each group all adopts the gavage administration.Gavage 30 days, model control group is given the normal saline gavage;
Blood fat reducing benefit health group, give natto powder, the Folium Crataegi extract mixture according to the ratio of 2: 1 forms, convert according to the middle dosage group of embodiment 11, after conversion, the dosage of natto powder is 88.33mg/kgBW, Folium Crataegi extract content is 44.17mg/kgBW, adds up to 132.5mg/kgBW;
Pericarpium Vitis viniferae extract group (6.625mg/kgBW);
Punica granatum L. group (35.49mg/kgBW).
Aspirin positive controls (8.33mg/kgBW), tested material gavages once a day with pure water (sterilizing) preparation, and gavage was tested after 30 days continuously.The rat oral gavage volume is that the 1.0ml/100g Mus is heavy.
Negative control and model control group replace tested material with pure water (sterilizing), and every day, the gavage volume was identical with each tested material group according to the 15ml/kg body weight.
2.2 modeling: begin modeling after third from the bottom gavage, precision takes carrageenin, is made into 3.5% (g/ml) concentration with normal saline; Weigh to rat, each group is all in metapedes toe subcutaneous injection carrageenin, and dosage is the 30mg/kg body weight.After modeling, rat is placed in (18 ± 2) ℃ indoor feeding, black tail length after measurement rat modeling 24h, 48h, 72h.After measuring the last time black tail length, each organizes rat anesthesia, and postcava is got whole blood, is sub-packed in two test tubes, get whole blood, measure thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT) and Fibrinogen (FIB).
3, statistical method
Continuous data relatively adopts the t check with meansigma methods ± standard error (mean ± standard error) expression, each group difference, is completed by the excel software statistics.P＜0.05 is that there were significant differences, and p＜0.01 is for there being utmost point significant difference.
4, results and analysis
The impact of natto on the rat tail 4.1 radically reform: see Table 1
Table 1: the effect of different product to rat black tail length (cm)
Annotate: compare with negative control group,
*P＜0.01,
* *P＜0.001; Compare with model group
#P＜0.05,
# #P＜0.01,
###P＜0.001.
As shown in Table 1:
Compare model group 48h black tail length utmost point phenomenal growth (P＜0.001) with negative control group;
In the time of 24 hours, compare the growth (P＜0.05) that blood fat reducing benefit health group obviously suppresses black tail with model group, aspirin, low dose group suppress the growth (P＜0.01) of black tail significantly, and middle dosage group and high dose group extremely significantly suppress the growth (P＜0.001) of black tail; Compare with the effect of blood fat reducing benefit health group, Pericarpium Vitis viniferae extract group, Punica granatum L. group, the effect of basic, normal, high dosage group all due to the effect of three groups, has synergism;
In the time of 48 hours, low dose group, aspirin group can suppress the growth (P＜0.01) of black tail significantly, and middle dosage group, high dose group can suppress the growth (P＜0.001) of black tail extremely significantly; Compare with the effect of blood fat reducing benefit health group, Pericarpium Vitis viniferae extract group, Punica granatum L. group, the effect of basic, normal, high dosage group all due to the effect of three groups, has synergism;
In the time of 72 hours, blood fat reducing benefit health group can significantly suppress the length (P＜0.05) of black tail, aspirin group, low dose group suppress the length (P＜0.01) of black tail significantly, middle and high dosage group can suppress the length (P＜0.001) of black tail extremely significantly, compare with the effect of blood fat reducing benefit health group, Pericarpium Vitis viniferae extract group, Punica granatum L. group, the effect of middle and high dosage group all due to the effect of three groups, has synergism.
The impact of natto on blood coagulation system 4.2 radically reform:
Table 2: the impact of natto on blood coagulation system of radically reforming
Annotate: compare with negative control group,
*P＜0.01,
* *P＜0.001; Compare with model group
#P＜0.05,
# #P＜0.01,
###P＜0.001.
Table 2 result shows:
Compare with negative control group, the thrombin time of model group significantly shortens (P＜0.01), and Fibrinogen increases, but without significant difference;
Compare with model group, blood fat reducing benefit health, Pericarpium Vitis viniferae extract group, Punica granatum L. group can significantly increase prothrombin time (P＜0.05), aspirin group, low dose group, middle dosage group can increase prothrombin time (P＜0.01) significantly, and high dose group can increase thrombin time (P＜0.001) extremely significantly;
Compare with the effect of blood fat reducing benefit health group, Pericarpium Vitis viniferae extract group, Punica granatum L. group, the successful of middle and high dosage group is better than this effect, has synergy.
Equally, embodiments of the invention 1-10 and all the other formulas of the present invention are tested, effect is identical with embodiment 11, all can suppress the length of black tail, the time of increase thrombinogen, has synergy.
Conclusion: the natto of radically reforming can have remarkable minimizing black tail length, the formation of pre-preventing thrombosis; The natto of radically reforming can have the appreciable impact blood coagulation system, extends the APTT time, proves that the present invention has the effect of Synergistic.
Although, above used general explanation, the specific embodiment and test, the present invention is described in detail, on basis of the present invention, can make some modifications or improvement to it, and this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (7)
1. health product that prevent microthrombusis, comprise active component, it is characterized in that, the active component of these health product is grouped into by the one-tenth of following weight portion: natto powder 1-3 part, Pericarpium Vitis viniferae extract 0.8-3 part, Fructus Crataegi powder 8-25 part, Punica granatum L. powder 3-15 part, and described Pericarpium Vitis viniferae extract: Pericarpium Vitis viniferae uses water extraction or alcohol extraction; Described Fructus Crataegi powder is the Fructus Crataegi pulp after enucleation, and spray drying makes; Described Punica granatum L. powder is that Punica granatum L. is squeezed the juice, and drying makes.
2. health product according to claim 1, is characterized in that, the active component of these health product is grouped into by the one-tenth of following weight portion: natto powder 1.5-2.5 part, Pericarpium Vitis viniferae extract 1-2 part, Fructus Crataegi powder 15-20 part, Punica granatum L. powder 5-10 part.
3. health product according to claim 1, is characterized in that, the active component of these health product is grouped into by the one-tenth of following weight portion: 1.6 parts of natto powders, 1.4 parts of Pericarpium Vitis viniferae extract, 17.50 parts of Fructus Crataegi powder, 7.50 parts, Punica granatum L. powder.
4. according to claim 1-3 described health product of any one is characterized in that described natto powder: after the steaming and decocting of Semen Glycines water, and the inoculation fermenting bacillus natto, drying is pulverized, and be get final product.
5. according to claim 1-3 described health product of any one, is characterized in that, these health product also contain adjuvant, is selected from one or more in hydroxyl isomaltulose, lactose, Sorbitol or magnesium stearate.
6. a method for preparing the described health product of claim 1-5 any one, is characterized in that, the method comprises the following steps: with the supplementary material mix homogeneously, and tabletting, and get final product.
7. the described health product of claim 1-5 any one are in the health product of preparation prevention microthrombusis and the application in medicine.
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|---|---|---|---|---|
| CN1714675A (en) * | 2005-07-26 | 2006-01-04 | 李英姬 | Natto powder and preparing method and health food containing such natto powder |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1714675A (en) * | 2005-07-26 | 2006-01-04 | 李英姬 | Natto powder and preparing method and health food containing such natto powder |
Non-Patent Citations (2)
| Title |
|---|
| 秋季水果,养生之宝;秋实;《中老年保健》;20071001(第10期);26-27 * |
| 秋实.秋季水果 养生之宝.《中老年保健》.2007 |
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