CN102885311A - Composite health food composition for alleviating physical fatigue and preparation method thereof - Google Patents
Composite health food composition for alleviating physical fatigue and preparation method thereof Download PDFInfo
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- CN102885311A CN102885311A CN2012103995582A CN201210399558A CN102885311A CN 102885311 A CN102885311 A CN 102885311A CN 2012103995582 A CN2012103995582 A CN 2012103995582A CN 201210399558 A CN201210399558 A CN 201210399558A CN 102885311 A CN102885311 A CN 102885311A
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Abstract
The invention discloses a composite health food for alleviating the physical fatigue and a preparation method of the composite health food. The composite health food comprises maca powder, paecilomyces hepialid, extract of the fruit of Chinese wolfberry and L-arginine hydrochloride. The invention further discloses the preparation method of the composite health food. Animal experiments prove that the composite health food has the function of alleviating the physical fatigue without any toxic and side effects.
Description
Technical field
The present invention relates to a kind of health-care food composition, be specifically related to health-care food composition of a kind of alleviating physical fatigue and preparation method thereof.
Background technology
The factors such as rhythm of life quickening, operating pressure increase, natural environment deterioration there are some researches show that sub-health population accounts for about 75% at high proportion so that increasing people are in sub-health state.Though inferior health has many clinical manifestations, main modal symptom is tired.
In recent years, many scholars are doing a lot of work aspect the anti-fatigue medicament research, find that a lot of Chinese medicines have certain curative effect to antifatigue, for example American Ginseng, rhodiola root, barrenwort, ginseng, Chinese yam, Fructus Aurantii, the tuber of dwarf lilyturf, Radix Codonopsis, the Radix Astragali, Cordyceps sinensis, Radix Angelicae Sinensis, cultivated land etc., and then prepare a series of anti-fatigue medicament or food.
The agate coffee (
Lepidium meyeniiWalpers) be the herbaceous plant that originates in mountain area, Peru Andean, belong to the Cruciferae separate row Vegetable spp.The main edible part of agate coffee is the main food of South American region locals for the ripe piece root that expands, and also uses as conventional medicament simultaneously.Except containing the nutritional labelings such as rich in protein, amino acid, mineral matter, also contain agate coffee alkene, maca polysaccharide, agate coffee acid amides isoreactivity material in the agate coffee.There are some researches show that maca polysaccharide has antifatigue pharmacology function.
Paecilomyces hepiali chen is that Cordyceps Militaris-Paecilomyces hepiali chen separating obtained from the fresh Cordyceps sinensis of Clavicipitaceae is cultivated the product that obtains through submerged fermentation, Paecilomyces hepiali chen and natural cordyceps chemical composition are basically identical, and similar pharmacological action and clinical effectiveness are arranged, pharmacological research shows that it can prolong the mouse swimming time, has to strengthen muscle power and to the resistivity of stressed condition.
The fruit of Chinese wolfberry is traditional Chinese medicine simply, distinguish the flavor of sweet, property flat, returns liver, kidney channel, the effect such as have tonifying kidney and benefiting sperm, nourish the liver to improve visual acuity.Modern medicine study shows that the fruit of Chinese wolfberry can increase storage capacity, the reduction blood lactate concentration of exercised rats glycogen, has anti-fatigue effect.
L-R-gene (L-arginine hydrochloride) is the hydrochloride of L-arginine, L-arginine is essential amino acid, it participates in the synthetic of histocyte protein, urea, creatine, creatinine, nitric oxide, glutamine, pyrimidine etc. in vivo, and can affect multiple endocrine hormone release.But L-arginine synthesis capability in human body is lower, needs part to replenish from food.Because the aobvious strong basicity of the arginine aqueous solution, absorbing carbon dioxide from air is made into hydrochloride more.Use mainly as nutritional supplement at present.
Existing anti-fatigue medicament or health food mostly are greatly the composition of kinds of traditional Chinese medicines material, and in above-mentioned several raw material, only there is report to show the fruit of Chinese wolfberry and Chinese caterpillar fungus compatibility, the agate coffee is the new resource food of Ministry of Public Health's approval, utilizes at present the product of this raw material few, utilizes prospect very good.
Summary of the invention
In order to solve the low problem of agate coffee health food utilization rate in the prior art, the invention provides a kind of health-care food composition of alleviating physical fatigue, comprise pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E and L-R-gene.Described Fructus lycii P.E is take the fruit of Chinese wolfberry as raw material, extract to obtain by conventional method, also can directly buy the commercially available prod.
As a kind of preferred version, each composition of the health-care food composition of this alleviating physical fatigue is counted by weight: pueraria root powder 150-200, Paecilomyces hepiali chen 150-200, Fructus lycii P.E 55-115, L-R-gene 20-60.
As a kind of preferred version, each composition of the health-care food composition of this alleviating physical fatigue is counted by weight: pueraria root powder 170, Paecilomyces hepiali chen 170, Fructus lycii P.E 85, L-R-gene 40.
More preferably, the health-care food composition of above-mentioned alleviating physical fatigue, the protein content in the described pueraria root powder 〉=10%, the adenosine content 〉=1.8mg/g in the Paecilomyces hepiali chen, thick polyoses content in the Fructus lycii P.E 〉=6%, the purity of L-R-gene 〉=99%.
The present invention also provides a kind of health food of alleviating physical fatigue, is comprised of health-care food composition and the pharmaceutically acceptable auxiliary material of above-mentioned alleviating physical fatigue.Described pharmaceutically acceptable auxiliary material comprises food and the spendable auxiliary material of medicine field.
Preferably, the health food formulation of above-mentioned alleviating physical fatigue is tablet, capsule, pill, granule or pulvis.
More preferably, described formulation is capsule, and described auxiliary material is starch and dolomol.
The present invention also provides the preparation method of the health food of above-mentioned alleviating physical fatigue, and step is as follows:
(1) pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch and dolomol are crossed respectively the 60-100 mesh sieve, take by weighing each raw material by prescription, mix (preferred 15-45 minute), get mixed powder;
(2) mixed powder filled capsules, capsule through polishing, get finished product again.
The present invention has following beneficial effect: health-care food composition of the present invention shows function with alleviating physical fatigue and without any side effects through animal experiment.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, can be implemented so that those skilled in the art can better understand the present invention also, but illustrated embodiment is not as a limitation of the invention.
In following examples, raw material: pueraria root powder (protein 〉=10%), available from the precious biochemical product of Shenyang she Co., Ltd; Fructus lycii P.E is available from prosperous Bioisystech Co., Ltd in the Shaanxi; L-R-gene (purity 〉=99%) is available from Tongxiang City Kang Nuo bio tech ltd; Paecilomyces hepiali chen is available from pharmaceutical Co. Ltd of Zhejiang Wan Feng enterprise group.
Embodiment 1 capsule
Raw material consumption (by weight meter): pueraria root powder 170, Paecilomyces hepiali chen 170, Fructus lycii P.E 85, L-R-gene 40, starch 32 and dolomol 3.
Pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol are crossed respectively 80 mesh sieves, and be for subsequent use.
Take by weighing pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol by described amount and jointly mixed 30 minutes, get mixed powder.Afterwards mixed powder is filled in the hard shell capsules, gets the loading capsule.The polishing of loading capsule is clean, gets finished product.Specification is the 0.5g/ grain.Contain among the every 100g of finished product: adenosine 49mg, thick polysaccharide 1g.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 2 capsules
Raw material consumption (by weight meter): pueraria root powder 150, Paecilomyces hepiali chen 200, Fructus lycii P.E 55, L-R-gene 60, starch 30 and dolomol 5.
Pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol are crossed respectively 60 mesh sieves, and be for subsequent use.
Take by weighing pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol by described amount and jointly mixed 25 minutes, get mixed powder.Afterwards mixed powder is filled in the hard shell capsules, gets the loading capsule.The polishing of loading capsule is clean, gets finished product.Specification is the 0.5g/ grain.Contain among the every 100g of finished product: adenosine 58mg, thick polysaccharide 0.55g.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 3 capsules
Raw material consumption (by weight meter): pueraria root powder 200, Paecilomyces hepiali chen 150, Fructus lycii P.E 115, L-R-gene 20, starch 11 and dolomol 4.
Pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol are crossed respectively 100 mesh sieves, and be for subsequent use.
Take by weighing pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol by described amount and jointly mixed 15 minutes, get mixed powder.Afterwards mixed powder is filled in the hard shell capsules, gets the loading capsule.The polishing of loading capsule is clean, gets finished product.Specification is the 0.5g/ grain.Contain among the every 100g of finished product: adenosine 43mg, thick polysaccharide 1.2g.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 4 tablets
Raw material consumption (by weight meter): pueraria root powder 170, Paecilomyces hepiali chen 170, Fructus lycii P.E 85, L-R-gene 40, starch 55, microcrystalline cellulose 175 and dolomol 5.
Pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, dolomol, microcrystalline cellulose are crossed respectively 80 mesh sieves, and be for subsequent use.
Take by weighing pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch, microcrystalline cellulose by described amount and jointly mixed 45 minutes, get mixed powder.Mixed powder adds 70% ethanol and prepares softwood, and softwood is granulated through 16 mesh sieves, 50-60 ℃ of drying, and the whole grain of 14 mesh sieves, particle mixes with dolomol, and compressing tablet gets finished product.Specification is the 0.7g/ sheet.Contain among the every 100g of finished product: adenosine 35mg, thick polysaccharide 0.6g.
Instructions of taking: every day 2 times, each 2.1g, sooner or later after meal respectively once.
Embodiment 5 securities and functional verification
Below study alleviating physical fatigue function and the edible safety (testing according to " health food check and assessment technique standard (2003 editions) " content) of health-care food composition of the present invention.
One, security detects
Acute toxicity test
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): select 20 of 18-22 gram SPF level Kunming mouses, male and female half and half, with the dosage per os secondary gavage of 15g/kgBW, Continuous Observation is 14 days after the administration.Record poisoning manifestations and death condition.
4. result: with the mouse of two kinds of sexes of dosage gavage of 15g/kgBW, observed 14 days.Experimental session has no obvious poisoning manifestations, and nothing is dead in the observation period.Tested material all greater than 15g/kgBW, according to " toxicological evaluation of food safety procedure and method " (version in 2003) acute toxicity classification, belongs to nontoxic level to the acute oral toxicity (MTD) of the mouse of two kinds of sexes.
The acute toxicity tests of table 1 mouse
| Animal | Sex | Number of animals (only) | Dosage (g/kgBW) | Death condition (only) | ?MTD(g/kg·BW) |
| Mouse | Male | 10 | 15 | 0 | >15 |
| Mouse | Female | 10 | 15 | 0 | >15 |
30 days feeding trials
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.It is 3g/60kgBW day that the people intends with dosage.
2. animal used as test: select body weight 60-80g, 80 of SD rats, male and female half and half.
3. test method: rat is divided into three tested material groups and a control group, 20 every group, male and female half and half at random.Control group is fed and is raised arm's length basis piece material; the tested material group is then fed and raised the basic blocks material that mixes the various dose sample, and dosage is designed to: basic, normal, high dosage group is respectively 1.25,2.50,5.00g/kgBW(is equivalent to respectively the people and intends with dosage 25 times, 50 times, 100 times).Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstance is observed:
Observe performance, behavior, toxicity performance and the death condition of animal every day.Weigh weekly 1 time and food intake dose twice, calculate weekly food utilization and total food utilization.Each treated animal grows as a result, activity is all normal, without poisoning manifestations and death, each treated animal weekly body weight, weekly body weight recruitment, weekly food-intake and food utilization weekly, and TBW recruitment, total food-intake and the equal no difference of science of statistics of total foodstuff utilization rate (
P0.05).
4.2 hematological examination:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) counting, leukocyte differential count (lymph, monokaryon, neutral grain, have a liking for acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count compare with control group equal no difference of science of statistics (
P0.05).
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).Experiment experimental animal in latter stage every biochemical indicator all in range of normal value, each treated animal blood biochemistry index compare with control group equal no difference of science of statistics (
P0.05).
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Animal is put to death in the dislocation of test cervical vertebra in latter stage, observes each main organs and chest, the change of abdominal cavity general pathology.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out liver, kidney, spleen, testis (or ovary), stomach and the duodenum of control group and high dose group animal, fix with 12% formalin, histological examination is carried out in FFPE, section, HE dyeing under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
Two, alleviating physical fatigue function test
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.It is 3g/60kgBW day that the people intends with dosage.
2. experimental animal: healthy Kunming mouse, body weight 18-22g, 15 every group.
3. swimming with a load attached to the body experiment
If basic, normal, high (0.5g/kgBW, 1 g/kgBW, 1.5g/kgBW) dosage group and control group (control animals gavage distilled water), successive administration 30 days, after last is subjected to test product 30min, the root of the tail section 5% body weight sheet lead of loading is placed the swimming trunk went swimming.The swimming of record mouse begins to Post-dead duration.
4, serum urea is measured
If basic, normal, high (0.25 g/kgBW, 0.5 g/kgBW, 1.5 g/kgBW) dosage group and control group (control animals gavage distilled water), successive administration 30 days, after last was subjected to test product 30min, not swimming with a load attached to the body 90min in 30 ℃ of water of temperature took a blood sample behind the rest 60min.Put 3h for 4 ℃, centrifuging and taking serum.Measure urea nitrogen.
5, hepatic glycogen is measured
If basic, normal, high (0.25 g/kgBW, 0.5 g/kgBW, 1.5 g/kgBW) dosage group and control group (control animals gavage distilled water), successive administration 30 days after last is subjected to test product 30min, is put to death animal, gets the mensuration that liver carries out hepatic glycogen.
6, blood Plasma lactate
If basic, normal, high (0.25 g/kgBW, 0.5 g/kgBW, 1.5 g/kgBW) dosage group and control group (control animals gavage distilled water), successive administration 30 days, after last is subjected to test product 30min, the blood sampling, after do not bear a heavy burden at 30 ℃ of water went swimmings of temperature 20min.Measure respectively area under blood lactic acid and the blood lactic acid.
7, result
Table 2 on the impact of mice burden swimming time (
± S)
| The dosage group | Swimming with a load attached to the body time min |
| High dose group | 12.07±2.81** |
| Middle dosage group | 11.47±2.66* |
| Low dose group | 9.92±3.29 |
| Control group | 8.09±2.17 |
* compare with control group
P＜0.05, * * and control group are relatively
P＜0.01.
Table 3 on mouse movement after serum urea level and hepatic glycogen content impact (
± S)
| The dosage group | Serum urea mmol/L | Hepatic glycogen mg/100g hepatic tissue |
| High dose group | 8.39±1.70** | 7414.7±1161.3** |
| Middle dosage group | 9.45±1.46 | 5860.1±1298.9** |
| Low dose group | 9.80±1.09 | 5371.8±1098.7** |
| Control group | 10.65±1.75 | 2903.4±927.6 |
* compare with control group
P＜0.05, * * and control group are relatively
P＜0.01.
Table 4 respectively organize blood lactic acid behind the mouse movement (TG-AUC of mg/L) (
± S)
| The dosage group | Quiet blood Lactate | 0min blood Lactate after the motion | 20 minutes blood Lactates move | Blood lactic acid TG-AUC | P |
| High dose group | 342.4±61.7 | 725.3±95.8 | 516.2±93.6 | 17752.8±2313.1 | 0.710 |
| Middle dosage group | 339.8±91.0 | 761.1±80.0 | 543.4±83.9 | 18549.6±1693.4 | 0.447 |
| Low dose group | 328.8±86.8 | 772.3±51.0 | 561.6±70.2 | 18844.8±1539.2 | 0.699 |
| Control group | 327.5±75.4 | 783.5±39.5 | 615.8±96.9 | 19548.8±1305.5 | - |
By " health food check with assessment technique standard (2003 editions) " basis for estimation: the swimming with a load attached to the body experiment is positive, and any two positives in the blood lactic acid, serum urea, hepatic glycogen biochemical indicator, can judge the function that is subjected to test product that alleviating physical fatigue is arranged.This product is by functional experiment, and 3 dosage groups and control group relatively all can obviously prolong the mice burden swimming time, and the serum urea that reduces tired mouse produces, and reduces urea level in the blood, the content of raising Mouse Liver glycogen.On blood lactic acid TG-AUC after the body weight gain of mouse and the motion without impact.Show that this product has the function of alleviating physical fatigue.
The above embodiment is the preferred embodiment that proves absolutely that the present invention lifts, and protection scope of the present invention is not limited to this.Being equal to that those skilled in the art do on basis of the present invention substitutes or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (8)
1. the health-care food composition of an alleviating physical fatigue is characterized in that, comprises pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E and L-R-gene.
2. the health-care food composition of alleviating physical fatigue according to claim 1 is characterized in that, each composition is counted by weight: pueraria root powder 150-200, Paecilomyces hepiali chen 150-200, Fructus lycii P.E 55-115, L-R-gene 20-60.
3. the health-care food composition of alleviating physical fatigue according to claim 1 is characterized in that, each composition is counted by weight: pueraria root powder 170, Paecilomyces hepiali chen 170, Fructus lycii P.E 85, L-R-gene 40.
4. the health-care food composition of arbitrary described alleviating physical fatigue according to claim 1-3, it is characterized in that, protein content in the described pueraria root powder 〉=10%, adenosine content 〉=1.8mg/g in the Paecilomyces hepiali chen, thick polyoses content in the Fructus lycii P.E 〉=6%, the purity of L-R-gene 〉=99%.
5. the health food of an alleviating physical fatigue is characterized in that being comprised of health-care food composition and the pharmaceutically acceptable auxiliary material of the arbitrary described alleviating physical fatigue of claim 1-3.
6. the health food of alleviating physical fatigue according to claim 5 is characterized in that formulation is tablet, capsule, pill, granule or pulvis.
7. the health food of alleviating physical fatigue according to claim 6 is characterized in that formulation is capsule, and described auxiliary material is starch and dolomol.
8. the preparation method of the health food of alleviating physical fatigue claimed in claim 7 is characterized in that, step is as follows:
(1) pueraria root powder, Paecilomyces hepiali chen, Fructus lycii P.E, L-R-gene, starch and dolomol are crossed respectively the 60-100 mesh sieve, take by weighing each raw material by prescription, mix, get mixed powder;
(2) mixed powder filled capsules, capsule through polishing, get finished product again.
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| CN104026568A (en) * | 2014-05-20 | 2014-09-10 | 青海伟康生物科技有限公司 | Health care product composition |
| CN104382002A (en) * | 2013-08-19 | 2015-03-04 | 宣城柏维力生物工程有限公司 | Maca tablet for alleviating fatigue |
| CN106173607A (en) * | 2015-05-05 | 2016-12-07 | 李宁 | Multifunctional and nutritional powder and preparation method thereof |
| CN109077317A (en) * | 2018-07-19 | 2018-12-25 | 深圳市博奥生物科技有限公司 | A kind of lycopene capsules and preparation method thereof |
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