CN102907663A - Healthcare food composition for relieving physical fatigue and preparation method of healthcare food composition - Google Patents
Healthcare food composition for relieving physical fatigue and preparation method of healthcare food composition Download PDFInfo
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Abstract
The invention discloses a healthcare food composition for relieving physical fatigue and a preparation method of the healthcare food composition. The healthcare food composition is made from the following medical components: maca powder, cordyceps militaris, cistanche and L-arginine hydrochloride. The invention also discloses the preparation method of the healthcare food composition. Animal tests indicate that the healthcare food composition disclosed by the invention has the function of relieving physical fatigue and has no side and toxic effects.
Description
Technical field
The present invention relates to health-care food composition of a kind of alleviating physical fatigue and preparation method thereof, belong to field of health care food.
Background technology
Physical fatigue is that the organism physiology process can not continue to carry out maybe keeping predetermined exercise intensity at specified level, can be divided into acute fatigue and confirmed fatigue according to its occurring mode, acute fatigue refers to that mainly body muscle is tired, show as limbs fatigue, aching pain of muscles, but spirit is fair.The decline of this muscle power just can recover by suitable rest and adjustment; Confirmed fatigue shows as then that pathological fatigue is continuous can not to be eased more than 6 months, simultaneously with situations such as insomnia, anxiety, physically-drainings.Confirmed fatigue is brought many harm to human body, and severe patient can occur suddenly dead.The tired stealthy killer who has become harm modern health.
The method that is used at present alleviating physical fatigue mainly contains 2 aspects, and the firstth, vitamin and the trace element of makeup energy, additional needed by human.Usually reach and keep the body normal physiological function, the purpose of relieving fatigue by replenishing the nutrition that consumes in the motion.The secondth, the function of function, the particularly circulatory system by improving biological organs, removing, the discharge of acceleration bodies intracellular metabolite material reach the antifatigue purpose.Product category is single in the prior art, and is alternative poor, and some product effect is also not obvious.
Summary of the invention
In order to solve the problems of the technologies described above, the invention provides a kind of health-care food composition of alleviating physical fatigue, this product is selected traditional Chinese medicine ingredients and amino acid compatibility, can bring into play the advantage of traditional Chinese medicine and related substance, is the health food of too many levels, multi-level, many target spots.
The health-care food composition of alleviating physical fatigue of the present invention is made by following effective component: pueraria root powder, Cordyceps militaris, saline cistanche and L-R-gene.
Preferably, the health-care food composition of alleviating physical fatigue of the present invention, made by the effective component of following parts by weight:
Pueraria root powder 150 ~ 250;
Cordyceps militaris 130 ~ 230;
Saline cistanche 350 ~ 450;
L-R-gene 20 ~ 60.
Further preferably, the health-care food composition of above-mentioned alleviating physical fatigue is hard shell capsules, also contains the adjunct ingredient of following parts by weight: starch 20 ~ 55; Dolomol 2 ~ 6.
As an optimal technical scheme, preferably, the health-care food composition of alleviating physical fatigue of the present invention, made by the effective component of following parts by weight:
Pueraria root powder 200;
Cordyceps militaris 180;
Saline cistanche 400;
L-R-gene 40.
Further preferably, the health-care food composition of above-mentioned alleviating physical fatigue is hard shell capsules, also contains the adjunct ingredient of following parts by weight: starch 36; Dolomol 4.
Preferably, the protein content of pueraria root powder 〉=10%; The adenosine content of Cordyceps militaris 〉=0.055%; The purity of L-R-gene 〉=99%.
The invention provides the preparation method of the health-care food composition of above-mentioned alleviating physical fatigue, comprise the steps: 1, obtain cistanche extracts through the saline cistanche extraction process; 2, get pueraria root powder, Cordyceps militaris, cistanche extracts and L-R-gene, be prepared into hard shell capsules, granule, tablet or pulvis with pharmaceutically acceptable carrier or auxiliary material.
Wherein, the saline cistanche extraction process is: saline cistanche is ground into thread, the concentration of volume percent that adds 4 ~ 8 times of saline cistanche weight is refluxing extraction 2 ~ 3 times in the ethanol water of 70 ~ 80 %, extract respectively 1 ~ 3h, extract merges filtration, and is concentrated, dry, pulverize, sieve, namely get cistanche extracts.
The present invention provides a kind of preparation method of health-care food composition of above-mentioned alleviating physical fatigue in addition, comprises the steps:
1) obtains cistanche extracts through the saline cistanche extraction process;
2) sieve: get pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol and cistanche extracts and cross respectively 80 mesh sieves;
3) weighing: take by weighing pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol and cistanche extracts after sieving, mix;
4) filled capsules: the mixed powder filled capsules that makes with step 3).
Wherein, above-mentioned saline cistanche extraction process is: saline cistanche is ground into thread, the concentration of volume percent that adds weight and be 4 ~ 8 times of saline cistanche weight is refluxing extraction 2 ~ 3 times in the ethanol water of 70 ~ 80 %, extract respectively 1 ~ 3h, extract merges filtration, and is concentrated, dry, pulverize, sieve, namely get cistanche extracts.
The present invention can reach following technique effect:
Health-care food composition of the present invention cooperates amino acid to be prepared from by Chinese medicine material, has the function of alleviating physical fatigue, and is without any side effects, and composition is clear and definite, and steady quality is easy to control.The person uses to be applicable to the fatiguability.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment, can be implemented so that those skilled in the art can better understand the present invention also, but illustrated embodiment is not as a limitation of the invention.
The invention provides a kind of health-care food composition of alleviating physical fatigue, made by following effective component: pueraria root powder, Cordyceps militaris, saline cistanche and L-R-gene.
Wherein, pueraria root powder is to be made through steps such as section, drying, pulverizing, sterilizations by the MAJIA Rhizome of artificial growth.Be rich in protein and dietary fiber isoreactivity composition.Pharmacological research shows that the agate coffee can prolong the mice burden swimming time, serum urea nitrogen level when reducing mouse movement, and help to eliminate the content of blood lactic acid behind the mouse movement.
Cordyceps militaris enters lung kidney two warps, and is can tonifying lung cloudy, again can kidney-replenishing, and cure mainly and suffer from a deficiency of the kidney, soreness of waist and knee joint, weak etc. after being ill, be a kind of simultaneously balance, regulate the Chinese medicine of negative and positive.Pharmacological research shows that it can prolong the mice burden swimming time, reduces blood urea nitrogen level, lactic acid content, the rising hepatic glycogen content.
Saline cistanche is hot, warm, enters spleen, stomach, large intestine channel, and warming middle energizer to promote qi is used for deficiency-cold in spleen and stomach.Pharmacological research shows that saline cistanche can make the mouse swimming time prolong, and SCK rising amplitude reduces behind the load exercise, and the general hyperplasia of mitochondria after the motion, hypertrophy and do not damage illustrate that saline cistanche can realize antifatigue effect on constitutional basis.
Arginine is a kind of essential amino acid of human body, it participates in the synthetic of histocyte protein, urea, creatine, creatinine, nitric oxide, glutamine, pyrimidine etc. in vivo, and can affect multiple endocrine hormone release, exogenous arginine need be made salt ability stable existence and be beneficial to absorption of human body, and commonly used is the L-R-gene.Pharmacological research shows that the L-R-gene can pass through NO, growth hormone and the realization of other metabolite to the antifatigue effect of body.
Preferably, the health-care food composition of above-mentioned alleviating physical fatigue, made by the effective component of following parts by weight:
Pueraria root powder 150 ~ 250;
Cordyceps militaris 130 ~ 230;
Saline cistanche 350 ~ 450;
L-R-gene 20 ~ 60.
Its preparation method is: 1, obtain cistanche extracts through the saline cistanche extraction process; 2, get pueraria root powder, Cordyceps militaris, cistanche extracts and L-R-gene, be prepared into hard shell capsules, granule, tablet or pulvis with pharmaceutically acceptable carrier or auxiliary material.
Wherein, the saline cistanche extraction process is: saline cistanche is ground into thread, the concentration of volume percent that adds 4 ~ 8 times of saline cistanche weight is refluxing extraction 2 ~ 3 times in the ethanol water of 70 ~ 80 %, extract respectively 1 ~ 3h, extract merges filtration, and is concentrated, dry, pulverize, sieve, namely get cistanche extracts.(in this area, the specific operation process of " extracting 2 ~ 3 times " is: 1) extract 1 time: saline cistanche is ground into thread, the concentration of volume percent that adds 4 ~ 8 times of saline cistanche weight is refluxing extraction 1 ~ 3h in the ethanol water of 70 ~ 80 %, filters, and gets dregs of a decoction and an extract; 2) extract 2 times: the concentration of volume percent that dregs of a decoction add 4 ~ 8 times of saline cistanche weight is refluxing extraction 1 ~ 3h in the ethanol water of 70 ~ 80 %, filters, and gets the secondary dregs of a decoction and secondary raffinate; 3) extract 3 times: the concentration of volume percent that the secondary dregs of a decoction add 4 ~ 8 times of saline cistanche weight is refluxing extraction 1 ~ 3h in the ethanol water of 70 ~ 80 %, filters, and gets three dregs of a decoction and No. three extracts)
Health-care food composition of the present invention can be made into multiple formulation, as: hard shell capsules, granule, tablet or pulvis etc.
By following preferred embodiment the present invention is further specified:
Embodiment 1 hard capsule
The health-care food composition of the present embodiment alleviating physical fatigue is made by effective component and adjunct ingredient, and each composition and parts by weight thereof are as follows:
Pueraria root powder 200;
Cordyceps militaris 180;
Saline cistanche 400;
L-R-gene 40;
Starch 36;
Dolomol 4.
Wherein the present embodiment is used: pueraria root powder (protein 〉=10%), available from the precious biochemical product of Shenyang she Co., Ltd; Cordyceps militaris (adenosine 〉=0.055%) is available from Zhuhai City elder generation health bio tech ltd; L-R-gene (purity 〉=99%), available from Tongxiang City Kang Nuo bio tech ltd, saline cistanche is available from the full Chinese medicine Co., Ltd of Anguo City justice.
The preparation method is:
(1) extraction of saline cistanche: take by weighing described amount saline cistanche and be ground into thread, 75% ethanol (ethanol water of the concentration of volume percent 75%) refluxing extraction that adding saline cistanche weight is 6 times 2 times, extract respectively 2h and 1.5h, extract merges filtration (namely, taking by weighing described amount saline cistanche is ground into thread, 75% alcohol reflux that adds 6 times of saline cistanche weight extracts 2h, filters, and gets dregs of a decoction and an extract; Get the dregs of a decoction one time, 75% alcohol reflux that adds 6 times of saline cistanche weight extracts 1.5h, gets the secondary dregs of a decoction and secondary raffinate, merges extract and secondary raffinate, filtration).Being evaporated to relative density is 1.10-1.20(60 ℃ of mensuration), the concentrate drying under reduced pressure was pulverized 80 mesh sieves.Get cistanche extracts.
(2) sieve: pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol are crossed respectively 80 mesh sieves.
(3) weighing: by described pueraria root powder, Cordyceps militaris, L-R-gene, starch, the dolomol that measures after sieving.
(4) mix: the supplementary material that takes by weighing mixed 30 minutes jointly with cistanche extracts.
(5) filled capsules: mixed powder incapsulates shell.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 2 hard capsules
The health-care food composition of the present embodiment alleviating physical fatigue is made by effective component and adjunct ingredient, and each composition and parts by weight thereof are as follows:
Pueraria root powder 150;
Cordyceps militaris 230;
Saline cistanche 350;
L-R-gene 60;
Starch 23;
Dolomol 2.
The preparation method is:
(1) extraction of saline cistanche: saline cistanche is ground into thread, and the concentration of volume percent 75% ethanol water refluxing extraction of 6 times of amounts of adding saline cistanche weight 2 times is extracted respectively 2h and 1.5h, and extract merges filtration.Being evaporated to relative density is approximately 60 ℃ of mensuration of 1.10-1.20(), the concentrate drying under reduced pressure was pulverized 80 mesh sieves.Get cistanche extracts.
(2) sieve: pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol are crossed respectively 80 mesh sieves.
(3) weighing: get pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol after sieving by formula rate.
(4) mix: the supplementary material that takes by weighing mixed 30 minutes jointly with cistanche extracts.
(5) filled capsules: mixed powder incapsulates shell.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 3 hard capsules
The health-care food composition of the present embodiment alleviating physical fatigue is made by effective component and adjunct ingredient, and each composition and parts by weight thereof are as follows:
Pueraria root powder 250;
Cordyceps militaris 130;
Saline cistanche 450;
L-R-gene 20;
Starch 50;
Dolomol 5.
The preparation method is:
(1) extraction of saline cistanche: saline cistanche is ground into thread, and the concentration of volume percent 75% ethanol water refluxing extraction of 6 times of amounts of adding saline cistanche weight 2 times is extracted respectively 2h and 1.5h, and extract merges filtration.Being evaporated to relative density is approximately 60 ℃ of mensuration of 1.10-1.20(), the concentrate drying under reduced pressure was pulverized 80 mesh sieves.Get cistanche extracts.
(2) sieve: pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol are crossed respectively 80 mesh sieves.
(3) weighing: get pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol after sieving by formula rate.
(4) mix: the supplementary material that takes by weighing mixed 30 minutes jointly with cistanche extracts.
(5) filled capsules: mixed powder incapsulates shell.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
Embodiment 4 granules
The health-care food composition of the present embodiment alleviating physical fatigue is made by effective component and adjunct ingredient, and each composition and parts by weight thereof are as follows:
Pueraria root powder 200;
Cordyceps militaris 180;
Saline cistanche 400;
L-R-gene 40;
Starch 36;
Dolomol 4.
The preparation method is:
(1) extraction of saline cistanche: saline cistanche is ground into thread, and refluxing extraction is 2 times in 75% ethanol water of 6 times of amounts of adding saline cistanche weight, extracts respectively 2h and 1.5h, and extract merges filtration.Being evaporated to relative density is 1.10-1.20(60 ℃ of mensuration), the concentrate drying under reduced pressure was pulverized 80 mesh sieves.Get cistanche extracts.
(2) sieve: pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol are crossed respectively 80 mesh sieves.
(3) weighing: get pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol after sieving by formula rate.The starch heating water is modulated into starch slurry.
(4) mix: pueraria root powder, Cordyceps militaris, L-R-gene, starch slurry mix the preparation softwood.
(5) granulation, drying: softwood is crossed 18 mesh sieves and is granulated, and 60 ℃ of dryings are crossed the whole grain of 16 mesh sieves.
(6) total mixed: particle and dolomol mix, and get final product.
Instructions of taking: every day 2 times, each 1.5g, sooner or later after meal respectively once.
The experiment of embodiment 5 compliance test results
Below study alleviating physical fatigue function and the edible safety (testing according to " health food check and assessment technique standard (2003 editions) " content) of health-care food composition of the present invention.
Acute toxicity test
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.
2. animal used as test: SPF level Kunming mouse.
3. its mouse oral acute toxicity test (MTD): select 20 of 18～22 gram SPF level Kunming mouses, male and female half and half, with the dosage per os secondary gavage of 20g/kgBW, Continuous Observation is 14 days after the administration.Record poisoning manifestations and death condition.
4. acute toxicity test: with the mouse of two kinds of sexes of dosage gavage of 20g/kgBW, observed 14 days.Experimental session has no obvious poisoning manifestations, and nothing is dead in the observation period.Tested material all greater than 20g/kgBW, according to " toxicological evaluation of food safety procedure and method " (version in 2003) acute toxicity classification, belongs to nontoxic level to the acute oral toxicity (MTD) of the mouse of two kinds of sexes.
The acute toxicity tests of mouse
30 days feeding trials
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.It is 3g/60kgBW day that the people intends with dosage.
2. animal used as test: select body weight 60～80g, 80 of SD rats, male and female half and half.
3. test method: dosage is designed to: 1.25,2.50,5.00g/kgBW(is equivalent to respectively the people and intends with dosage 25 times, 50 times, 100 times).Rat is divided into three tested material groups and control group at random, 20 every group, male and female half and half.Control group is fed and is raised arm's length basis piece material, and the tested material group is then fed to raise and mixed the various dose sample.Continuous Observation 30 days.
4. observation index and result
4.1 ordinary circumstance is observed:
Observe performance, behavior, toxicity performance and the death condition of animal every day.Weigh weekly 1 time and twice food intake dose, calculate and reach weekly total food utilization.Each treated animal grows as a result, activity is all normal, without poisoning manifestations and death, each treated animal weekly body weight, body weight recruitment, food-intake and food utilization and the equal no difference of science of statistics of TBW recruitment, food-intake and food utilization (
p0.05).
4.2 hematological examination:
Measuring hemoglobin content (Hgb), red blood cell (RBC) and leucocyte (WBC) counting, leukocyte differential count (lymph, monokaryon, neutral grain, have a liking for acid, basophilic).Experiment latter stage, hematological indices was all in range of normal value, each treated animal hemoglobin, red blood cell and white blood cell count(WBC), leukocyte differential count compare with control group equal no difference of science of statistics (
p0.05).
4.3 Biochemical Indexes:
Measure serum alanine aminotransferase (ALT), aspartate amino transferase (AST), urea nitrogen (BUN), cholesterol (CHO), triglycerides (TG), blood sugar (GLU), total protein (TP), albumin (ALB), creatinine (CRE).Experiment experimental animal in latter stage every biochemical indicator all in range of normal value, each treated animal blood biochemistry index compare with control group equal no difference of science of statistics (
p0.05).
4.4 gross examination of skeletal muscle and pathologic diagnosis:
Animal is put to death in the dislocation of test cervical vertebra in latter stage, observes each main organs and chest, the change of abdominal cavity general pathology.Take out liver, kidney, spleen, the testis of all animals, weigh and calculate organ coefficient.Take out liver, kidney, spleen, testis (or ovary), stomach and the duodenum of control group and high dose group animal, fix with 12% formalin, histological examination is carried out in FFPE, section, HE dyeing under light microscopic.Each main organs (heart, liver, spleen, lung, kidney, stomach, intestines etc.) is showed no significant pathological change.
Above-mentioned acute toxicity test and 30 days feeding trial results show that this product belongs to nontoxic level, can long-term taking.
The alleviating physical fatigue function test
1. sample: the sample of pressing the preparation of embodiment 1 described prescription and technique.It is 3g/60kgBW day that the people intends with dosage.
2. experimental animal: healthy Kunming mouse, body weight 18～22g, 15 every group.
3. swimming with a load attached to the body experiment
Basic, normal, high if (0.5g/kg.BW, 1 g/kg.BW, 1.5g/kg.BW) dosage group and control group, successive administration 30 days after last is subjected to test product 30min, places the swimming trunk went swimming with the root of the tail section 5% body weight sheet lead of loading.The swimming of record mouse begins to Post-dead duration.
| Group | Swimming time s | PValue |
| Control group | 297±106 | - |
| Low dose group | 455±152 | 0.014 |
| Middle dosage group | 452±168 | 0.017 |
| High dose group | 414±172 | 0.065 |
Comparing in twos of experimental group and control group, the swimming time of low, middle dosage group than the obvious prolongation of control group and have significant difference (
p＜0 .0 5).
4, serum urea is measured
Basic, normal, high if (0.25 g/kg.BW, 0.5 g/kg.BW, 1.5 g/kg.BW) dosage group and control group, successive administration 30 days, after last was subjected to test product 30min, not swimming with a load attached to the body 90min in 30 ℃ of water of temperature took a blood sample behind the rest 60min.Put 3h for 4 ℃, centrifuging and taking serum.Measure urea nitrogen.
| Group | Urea nitrogen content mmol/L |
| Control group | 3.78±0.53 |
| Low dose group | 3.64±0.38 |
| Middle dosage group | 3.60±0.43 |
| High dose group | 3.61±0.57 |
Serum urea nitrogen content there was no significant difference between each dosage group (
p0.0 5).
5, hepatic glycogen is measured
Basic, normal, high if (0.25 g/kg.BW, 0.5 g/kg.BW, 1.5 g/kg.BW) dosage group and control group, successive administration 30 days after last is subjected to test product 30min, is put to death animal, gets the mensuration that liver carries out hepatic glycogen.
| Group | Hepatic glycogen content mg/100g liver | PValue |
| Control group | 2392.6±884.2 | - |
| Low dose group | 5053.7±1068.5 | 0.000 |
| Middle dosage group | 5723.6±1115.6 | 0.000 |
| High dose group | 5204.6±1440.1 | 0.000 |
Comparing in twos of experimental group and control group, the hepatic glycogen of basic, normal, high dosage group than the obvious rising of control group and have utmost point significant difference (
p＜0.01).
6, blood Plasma lactate
Basic, normal, high if (0.25 g/kg.BW, 0.5 g/kg.BW, 1.5 g/kg.BW) dosage group and control group, successive administration 30 days, after last is subjected to test product 30min, the blood sampling, after do not bear a heavy burden at 30 ℃ of water went swimmings 10 of temperature, 20min.Measure respectively area under blood lactic acid and the blood lactic acid.
| Group | Before the motion | 10min after the motion | 20min after the motion | The lactic acid TG-AUC | PValue |
| Control group | 4.20±2.05 | 9.03±1.34 | 4.80±1.21 | 204.4±28.5 | - |
| Low dose group | 3.48±1.58 | 7.50±1.41 | 4.23±0.67 | 179.6±26.8 | 0.011 |
| Middle dosage group | 2.65±1.08 | 8.60±1.37 | 5.40±1.03 | 196.3±31.0 | 0.509 |
| High dose group | 3.50±1.34 | 8.85±1.56 | 5.20±1.17 | 202.3±33.0 | 0.862 |
Comparing in twos of experimental group and control group, the blood lactic acid TG-AUC of low dose group than the obvious reduction of control group and have significant difference (
P＜0.0 5).
By " health food check with assessment technique standard (2003 editions) " basis for estimation: the swimming with a load attached to the body experiment is positive, and any two positives in the blood lactic acid, serum urea, hepatic glycogen biochemical indicator, can judge the function that is subjected to test product that alleviating physical fatigue is arranged.This product is by functional experiment, and the swimming with a load attached to the body experiment positive, hepatic glycogen and blood lactic acid biochemical indicator are positive, therefore can judge that this product has the function of alleviating physical fatigue.
The health-care food composition of embodiment 2 ~ 4 preparation carries out above-mentioned zoopery equally, and the result shows: all have no side effect, and 30 days mouse of successive administration, the swimming with a load attached to the body experiment is positive, and any two positives in the blood lactic acid, serum urea, hepatic glycogen biochemical indicator.To sum up, health-care food composition of the present invention has the function of alleviating physical fatigue.
The above embodiment is the preferred embodiment that proves absolutely that the present invention lifts, and protection scope of the present invention is not limited to this.Being equal to that those skilled in the art do on basis of the present invention substitutes or conversion, all within protection scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (10)
1. the health-care food composition of an alleviating physical fatigue is characterized in that, is made by following effective component: pueraria root powder, Cordyceps militaris, saline cistanche and L-R-gene.
2. the health-care food composition of alleviating physical fatigue according to claim 1 is characterized in that, is made by the effective component of following parts by weight:
Pueraria root powder 150 ~ 250;
Cordyceps militaris 130 ~ 230;
Saline cistanche 350 ~ 450;
L-R-gene 20 ~ 60.
3. the health-care food composition of alleviating physical fatigue according to claim 2 is characterized in that, described health-care food composition is hard shell capsules, also contains the adjunct ingredient of following parts by weight: starch 20 ~ 55; Dolomol 2 ~ 6.
4. the health-care food composition of alleviating physical fatigue according to claim 1 is characterized in that, is made by the effective component of following parts by weight:
Pueraria root powder 200;
Cordyceps militaris 180;
Saline cistanche 400;
L-R-gene 40.
5. the health-care food composition of alleviating physical fatigue according to claim 4 is characterized in that, described health-care food composition is hard shell capsules, also contains the adjunct ingredient of following parts by weight: starch 36; Dolomol 4.
6. the health-care food composition of each described alleviating physical fatigue is characterized in that according to claim 1 ~ 5, the protein content of described pueraria root powder 〉=10%; The adenosine content of Cordyceps militaris 〉=0.055%; The purity of L-R-gene 〉=99%.
7. the preparation method of the health-care food composition of claim 1,2 or 4 described alleviating physical fatigues is characterized in that, comprises the steps: 1, obtains cistanche extracts through the saline cistanche extraction process; 2, get pueraria root powder, Cordyceps militaris, cistanche extracts and L-R-gene, be prepared into hard shell capsules, granule, tablet or pulvis with pharmaceutically acceptable carrier or auxiliary material.
8. preparation method according to claim 7, it is characterized in that, the saline cistanche extraction process is: saline cistanche is ground into thread, and the concentration of volume percent that adds 4 ~ 8 times of saline cistanche weight is the ethanol water of 70 ~ 80 %, refluxing extraction 2 ~ 3 times, extract respectively 1 ~ 3h, extract merges filtration, and is concentrated, dry, pulverize, sieve, namely get cistanche extracts.
9. the preparation method of the health-care food composition of claim 3 or 5 described alleviating physical fatigues is characterized in that, comprises the steps:
1) obtains cistanche extracts through the saline cistanche extraction process;
2) sieve: get pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol and cistanche extracts and cross respectively 80 mesh sieves;
3) weighing: take by weighing pueraria root powder, Cordyceps militaris, L-R-gene, starch, dolomol and cistanche extracts after sieving, mix;
4) filled capsules: the mixed powder filled capsules that makes with step 3).
10. preparation method according to claim 9, it is characterized in that, described saline cistanche extraction process is: saline cistanche is ground into thread, and adding weight is that the concentration of volume percent of 4 ~ 8 times of saline cistanche weight is 70 ~ 80% ethanol water, refluxing extraction 2 ~ 3 times, extract respectively 1 ~ 3h, extract merges filtration, and is concentrated, dry, pulverize, sieve, namely get cistanche extracts.
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| CN103393195A (en) * | 2013-08-08 | 2013-11-20 | 西藏现代农业有限公司 | Cordyceps beverage and preparation method thereof |
| CN103859412A (en) * | 2014-04-02 | 2014-06-18 | 南京慧博生物科技有限公司 | Health-care food for male and preparation method thereof |
| CN104382002A (en) * | 2013-08-19 | 2015-03-04 | 宣城柏维力生物工程有限公司 | Maca tablet for alleviating fatigue |
| CN105998536A (en) * | 2016-07-27 | 2016-10-12 | 浙江省磐安县外贸药业有限公司 | Maca tablet and preparation method thereof |
| CN106172953A (en) * | 2016-07-08 | 2016-12-07 | 陕西理工学院 | A kind of black tea rich in phenethyl alcohol glycoside and its preparation method and application |
| CN107212401A (en) * | 2017-06-12 | 2017-09-29 | 重庆市生物技术研究所有限责任公司 | Composition for relieving physical fatigue and its preparation and preparation method |
| CN108066562A (en) * | 2017-12-29 | 2018-05-25 | 浙江大晟药业有限公司 | A kind of Herba Cistanches piece and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103393195A (en) * | 2013-08-08 | 2013-11-20 | 西藏现代农业有限公司 | Cordyceps beverage and preparation method thereof |
| CN104382002A (en) * | 2013-08-19 | 2015-03-04 | 宣城柏维力生物工程有限公司 | Maca tablet for alleviating fatigue |
| CN103859412A (en) * | 2014-04-02 | 2014-06-18 | 南京慧博生物科技有限公司 | Health-care food for male and preparation method thereof |
| CN103859412B (en) * | 2014-04-02 | 2015-06-03 | 江苏慧博生物科技有限公司 | Health-care food for male and preparation method thereof |
| CN106172953A (en) * | 2016-07-08 | 2016-12-07 | 陕西理工学院 | A kind of black tea rich in phenethyl alcohol glycoside and its preparation method and application |
| CN105998536A (en) * | 2016-07-27 | 2016-10-12 | 浙江省磐安县外贸药业有限公司 | Maca tablet and preparation method thereof |
| CN107212401A (en) * | 2017-06-12 | 2017-09-29 | 重庆市生物技术研究所有限责任公司 | Composition for relieving physical fatigue and its preparation and preparation method |
| CN108066562A (en) * | 2017-12-29 | 2018-05-25 | 浙江大晟药业有限公司 | A kind of Herba Cistanches piece and preparation method thereof |
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