CN101129604B - Antihypelipidemic traditional Chinese medicine producing method - Google Patents
Antihypelipidemic traditional Chinese medicine producing method Download PDFInfo
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- CN101129604B CN101129604B CN200710072728A CN200710072728A CN101129604B CN 101129604 B CN101129604 B CN 101129604B CN 200710072728 A CN200710072728 A CN 200710072728A CN 200710072728 A CN200710072728 A CN 200710072728A CN 101129604 B CN101129604 B CN 101129604B
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Abstract
The invention discloses an antihypelipidemic traditional Chinese medicine and making method to solve the problem of toxic and side action for human body of diabetic patient during long periodical treating course, which comprises the following parts: 300-600wt% balsam pear, 50-150wt% wintercherry fruit and 200-400wt% tangerine peel. The making method comprises the following steps: leaching the balsam pear water; purifying tangerine peel benzine through distilling method; using residual tangerine peel wintercherry fruit to extract through alcohol; decompressing and condensing the filtrate; blending the extract and benzine. Another preparing method comprises the following steps: using distilling method to extract tangerine peel benzine; preparing the extract of tangerine peel, balsam pear, wintercherry fruit astragalus root and licorice root; blending the extract and benzine. The invention can respond within 5 days with efficiency at 94. 4%, which can be intaken periodically without anyside effect for human body.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine.
Background technology
Diabetes have become one of important diseases of puzzlement health of people, add up according to interrelated data, the crowd who suffers from diabetes has the trend that increases year by year, the factor that forms diabetes is a lot, mainly contains obesity, lacks motion, bad dietary habit etc., and the key of prevent diabetes is to keep normal blood sugar level, and the blood glucose of normal level is extremely important for the physiological function of each histoorgan of human body, and secular hyperglycemia can make each internal organs of whole body and tissue that pathological change takes place, bigger to body harm, mainly show as: cause blood vessel, neural complication, the β cell function is weak, electrolyte disturbance, serious dehydration, osmotic pressure increases, malaise, visual deterioration etc.And hyperglycemia is one of the most direct sign of diabetes, and the complication in diabetes later stage also mainly is caused by hyperglycemia, therefore control normal blood sugar level and be ensure healthy, away from the key of diabetes.At present, the oral drugs of treatment diabetes mainly are Western medicine, though the Western medicine blood sugar lowering is very fast, side effect is obvious, to the human body toxic side effect, is unfavorable for taking for a long time.
Summary of the invention
The present invention uses the problem of oral western medicine to the human body toxic side effect in order to solve the diabetes patient in the therapeutic process midium or long term, and has proposed a kind of preparation method of blood-sugar lowering tcm drug.A kind of blood-sugar lowering tcm drug is mainly made by 300～600 portions of Fructus Momordicae charantiaes, 50～150 parts of Calyx Seu Fructus Physaliss and 200～400 parts of Pericarpium Citri Reticulataes according to ratio of weight and number.A kind of preparation method of blood-sugar lowering tcm drug realizes by following steps: one, according to ratio of weight and number 300～600 portions of Fructus Momordicae charantiaes are gone to be cut into the thick decoction pieces of 1～2mm behind the flesh, then decoction pieces is carried out drying being lower than under 60 ℃ the condition; Two, dried Fructus Momordicae charantiae decoction pieces is put into deionized water and was soaked 0.5～1.5 hour, and decocting after 2～4 hours with filter paper or molecular weight is 10000～20000 daltonian ultrafiltration membrance filters again, and it is 1.25～1.30 Fructus Momordicae charantiae the water extracted immersing paste that filtrate decompression is condensed into proportion; Three, it is standby to extract the volatile oil of 200～400 parts of Pericarpium Citri Reticulataes with steam distillation, and to put into mass concentration be to carry out alcohol extraction in 60～80% the alcoholic solution to reclaim until obtaining proportion with the reclaim under reduced pressure method to ethanol after 2～4 hours be 1.25～1.30 alcohol-extracted extract with extracting the remaining Pericarpium Citri Reticulatae in back and 50～150 parts of Calyx Seu Fructus Physaliss; Four, alcohol-extracted extract is put into deionized water for stirring, leaving standstill after 12 hours with filter paper or molecular weight is that 1000～2000 daltonian ultrafilter membranes filter water lotion, and it is 1.25～1.30 Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum that decompression is condensed into proportion with filtrate; Five, Fructus Momordicae charantiae the water extracted immersing paste, Pericarpium Citri Reticulatae volatile oil and Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum are mixed, obtain blood-sugar lowering tcm drug.The another kind of preparation method of blood-sugar lowering tcm drug realizes by following steps: one, standby with the volatile oil of 200～400 parts of Pericarpium Citri Reticulataes of steam distillation extraction; Two, extracting the remaining Pericarpium Citri Reticulatae in back and 300～600 portions of Fructus Momordicae charantiaes, 50～150 parts of Calyx Seu Fructus Physaliss, 200～400 parts of Radixs Astragali, 150～300 portions of Radix Glycyrrhizaes puts into deionized water and decocted 2～4 hours, be 10000～20000 daltonian ultrafiltration membrance filters with filter paper or molecular weight then, it is 1.25～1.30 extractum that filtrate decompression is condensed into proportion; Three, extractum and the Pericarpium Citri Reticulatae volatile oil with gained mixes, and obtains blood-sugar lowering tcm drug.
Blood-sugar lowering tcm drug of the present invention is taken and can be taken effect in 5 days, and effective percentage is up to 94.4%, and the present invention adopts the pure natural plant preparation, and is without any side effects to human body, can take for a long time.
The specific embodiment
The specific embodiment one: the present embodiment blood-sugar lowering tcm drug is made by 300～600 portions of Fructus Momordicae charantiaes, 50～150 parts of Calyx Seu Fructus Physaliss and 200～400 parts of Pericarpium Citri Reticulataes according to ratio of weight and number.
The specific embodiment two: the difference of the present embodiment and the specific embodiment one is that blood-sugar lowering tcm drug mainly made by 350～550 portions of Fructus Momordicae charantiaes, 60～140 parts of Calyx Seu Fructus Physaliss and 220～380 parts of Pericarpium Citri Reticulataes according to ratio of weight and number.
The specific embodiment three: the difference of the present embodiment and the specific embodiment one is that blood-sugar lowering tcm drug mainly made by 400～500 portions of Fructus Momordicae charantiaes, 70～120 parts of Calyx Seu Fructus Physaliss and 250～350 parts of Pericarpium Citri Reticulataes according to ratio of weight and number.
The specific embodiment four: the difference of the present embodiment and the specific embodiment one is that blood-sugar lowering tcm drug mainly made by 305 portions of Fructus Momordicae charantiaes, 75 parts of Calyx Seu Fructus Physaliss and 240 parts of Pericarpium Citri Reticulataes according to ratio of weight and number.
The specific embodiment five: the difference of the present embodiment and the specific embodiment one is that blood-sugar lowering tcm drug also adds 200～400 parts of Radixs Astragali and 150～300 portions of Radix Glycyrrhizaes according to ratio of weight and number.Other composition is identical with the specific embodiment one.
The specific embodiment six: the preparation method of present embodiment blood-sugar lowering tcm drug realizes by following steps: one, according to ratio of weight and number 300～600 portions of Fructus Momordicae charantiaes are gone to be cut into the thick decoction pieces of 1～2mm behind the flesh, then decoction pieces is carried out drying being lower than under 60 ℃ the condition; Two, dried Fructus Momordicae charantiae decoction pieces is put into deionized water immersion 0.5～1.5 hour, decocting after 2～4 hours with filter paper or molecular weight is 10000～20000 daltonian ultrafiltration membrance filters again, and it is 1.25～1.30 Fructus Momordicae charantiae the water extracted immersing paste that decompression is condensed into proportion with filtrate; Three, it is standby to extract the volatile oil of 200～400 parts of Pericarpium Citri Reticulataes with steam distillation, and to put into mass concentration be to carry out alcohol extraction in 60～80% the alcoholic solution to reclaim until obtaining proportion with the reclaim under reduced pressure method to ethanol after 2～4 hours be 1.25～1.30 alcohol-extracted extract with extracting the remaining Pericarpium Citri Reticulatae in back and 50～150 parts of Calyx Seu Fructus Physaliss; Four, alcohol-extracted extract is put into deionized water for stirring, leaving standstill after 12 hours with filter paper or molecular weight is that 1000～2000 daltonian ultrafilter membranes filter water lotion, and it is 1.25～1.30 Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum that filtrate decompression is condensed into proportion; Five, Fructus Momordicae charantiae the water extracted immersing paste, Pericarpium Citri Reticulatae volatile oil and Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum are mixed, obtain blood-sugar lowering tcm drug.
A kind of blood-sugar lowering tcm drug of present embodiment preparation removes has blood sugar reducing function, also has nourishing YIN and clearing away heat, the effect of regulating qi-flowing for strengthening spleen.Present embodiment proportion detects under 40 ℃ of conditions.
Can add the excipient (Fructus Cucurbitae moschatae powder) that does not influence drug effect in the present embodiment step 5 and make different dosage form.
With the blood-sugar lowering tcm drug of preparing in the present embodiment 18 routine hyperglycemia and diabetics are treated, take the 4g ingredient at every turn, three the laggard promoting the circulation of blood sugar results that take medicine every day observe, produce effects (blood glucose reaches normal value) 6 examples, 11 examples are (blood glucose value changes) effectively, and 1 example is invalid, and total effective rate reaches 94.4%, generally taking five days is visible positive effect, does not see any toxic and side effects in actual applications.
Blood-sugar lowering tcm drug with the present embodiment preparation carries out pharmacological testing:
1 experiment material
1.1 animal: Kunming mouse, body weight 20 ± 2g, male and female half and half, provided by Harbin Medical University's Experimental Animal Center, the quality certification is numbered 060508.
1.2 key instrument: 722 type spectrophotometers (Shanghai analytical tool factory), high speed micro centrifuge (Jiangsu medical centrifuge factory).
1.3 reagent: serum glucose is measured test kit, is built up Bioisystech Co., Ltd's production (lot number 20060303) by Shanghai; The adrenalin hydrochloride injection, produce (lot number 20060614) by Tianjin aminoacid people pharmaceutical factory.
2 experimental techniques
2.1 preliminary blood sugar lowering drug efficacy study
2.1.1 the preparation of medicinal liquid
The medicinal liquid of medicine in the present embodiment being made every 18g/100ml is standby.
2.1.2 get 30 of healthy Kunming mouses, be divided into 3 groups, every group 10 at random, male and female half and half.
Medicine group mice every day is according to the dosed administration of 6.0g/kg, model group and the blank group 0.5ml that pours water every day, continuous irrigation stomach 10 days, 12h fasting (can't help water) before the last administration, behind the 10th day perfusion 2h, administration group and model control group are all pressed body weight 0.2mg/kg dosage lumbar injection adrenalin hydrochloride respectively, blank group injection equivalent normal saline, injection back 30min adopts the glucose oxidase method docking to get blood, measures blood glucose value.The results are shown in Table 1.
Table 1
| Group | Number of animals (only) | Dosage g/ (kgd) | Blood glucose value (x ± s) | |
| 1 | The administration group | 10 | 6.0 | 190.7±30.3 * |
| 2 | Model group | 10 | - | 251.6±32.5 |
| 3 | The blank group | 10 | - | 130.2±26.5 |
Annotate: with the model group ratio
*P＜0.01
The administration group is described under dosage 6.0g/ (kgd) situation, medicine has the effect of obvious suppression blood sugar increasing.
2.2 research to model induced by alloxan mice diabetes model
2.2.1 the preparation of medicinal liquid
The medicinal liquid of medicine in the present embodiment being made every 18g/100ml is standby.
2.2.2 get 50 of healthy Kunming mouses, be divided into 5 groups (low dosage administration group, middle dosed administration group, high dose administration group, model group and blank groups) at random, 10 every group.Weigh in behind mice fasting (the can't help water) 12h, low dosage administration group, middle dosed administration group, high dose administration group and model group are respectively by every 80mgkg dosage of mice tail vein injection 1% alloxan liquid, and the blank group is injected the equivalent normal saline; Injection back low dosage administration group, middle dosed administration group and perfusion of high dose administration group mice in the 4th day, blank group and model group are irritated distilled water 0.5ml every day, continuous irrigation stomach 10 days, 12h fasting (can't help water) before the last administration, blood is got in docking behind the 10th day perfusion 2h, the centrifugal serum that obtains, the using glucose oxidase method is measured blood glucose value, the results are shown in Table 2.
Table 2
| Group | Number of animals (only) | Dosage (g/kg.d) | Blood glucose value (x ± s) | |
| 1 | Low dosage administration group | 10 | 3.0 | 223.7±108.9 |
| 2 | Middle dosed administration group | 10 | 6.0 | 156.4±49.7 ** |
| 3 | High dose administration group | 10 | 12.0 | 149.8±66.2 ** |
| 4 | Model group | 10 | - | 265.6±72.5 |
| Group | Number of animals (only) | Dosage (g/kg.d) | Blood glucose value (x ± s) | |
| 5 | The blank group | 10 | - | 130.2±23.5 |
Annotate: with the model group ratio
*P＜0.001
Above result shows to model induced by alloxan mice diabetes model, with 6.0g/ (kgd) and the administration of 12.0g/ (kgd) dosage treatment, all to have extremely significant blood sugar reducing function.
The specific embodiment seven: present embodiment and the difference of the specific embodiment six be in the step 5 Pericarpium Citri Reticulatae volatile oil with use cyclodextrin inclusion compound before Fructus Momordicae charantiae the water extracted immersing paste and Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum mix.Other step is identical with the specific embodiment six.
The specific embodiment eight: the difference of the present embodiment and the specific embodiment six is that the quality of deionized water in the step 2 is 6～14 times of Fructus Momordicae charantiae decoction pieces.Other step is identical with the specific embodiment six.
The specific embodiment nine: the difference of the present embodiment and the specific embodiment six is in the step 3 just to extract the remaining Pericarpium Citri Reticulatae in back and 60～140 parts of Calyx Seu Fructus Physaliss, and to put into mass concentration be to carry out alcohol extraction in 65～75% the alcoholic solution to reclaim until obtaining proportion with the reclaim under reduced pressure method to ethanol after 3 hours be 1.26～1.30 alcohol-extracted extract.Other step is identical with the specific embodiment six.
The specific embodiment ten: the difference of the present embodiment and the specific embodiment six is that the quality of deionized water in the step 4 is 2～4 times of alcohol-extracted extract.Other step is identical with the specific embodiment six.
The specific embodiment 11: the preparation method of present embodiment blood-sugar lowering tcm drug realizes by following steps: one, standby with the volatile oil of 200～400 parts of Pericarpium Citri Reticulataes of steam distillation extraction; Two, extracting the remaining Pericarpium Citri Reticulatae in back and 300～600 portions of Fructus Momordicae charantiaes, 50～150 parts of Calyx Seu Fructus Physaliss, 200～400 parts of Radixs Astragali, 150～300 portions of Radix Glycyrrhizaes puts into deionized water and decocted 2～4 hours, be 10000～20000 daltonian ultrafiltration membrance filters with filter paper or molecular weight then, it is 1.25～1.30 extractum that filtrate decompression is condensed into proportion; Three, extractum and the Pericarpium Citri Reticulatae volatile oil with gained mixes, and obtains blood-sugar lowering tcm drug.
Present embodiment proportion detects under 40 ℃ of conditions.
With the blood-sugar lowering tcm drug of preparing in the present embodiment 18 routine hyperglycemia and diabetics are treated, take the 4g ingredient at every turn, three the laggard promoting the circulation of blood sugar results that take medicine every day observe, produce effects (blood glucose reaches normal value) 8 examples, 10 examples are (blood glucose value changes) effectively, total effective rate reaches 100%, and generally taking five days is visible positive effect, does not see any toxic and side effects in actual applications.
Claims (5)
1. the preparation method of a blood-sugar lowering tcm drug, the preparation method that it is characterized in that blood-sugar lowering tcm drug realizes by following steps: one, according to ratio of weight and number 300～600 portions of Fructus Momordicae charantiaes are gone to be cut into the thick decoction pieces of 1～2mm behind the flesh, then decoction pieces is carried out drying being lower than under 60 ℃ the condition; Two, dried Fructus Momordicae charantiae decoction pieces is put into deionized water immersion 0.5～1.5 hour, decocting after 2～4 hours with filter paper or molecular weight is 10000～20000 daltonian ultrafiltration membrance filters again, and it is 1.25～1.30 Fructus Momordicae charantiae the water extracted immersing paste that decompression is condensed into proportion with filtrate; Three, it is standby to extract the volatile oil of 200～400 parts of Pericarpium Citri Reticulataes with steam distillation, and to put into mass concentration be to carry out alcohol extraction in 60～80% the alcoholic solution to reclaim until obtaining proportion with the reclaim under reduced pressure method to ethanol after 2～4 hours be 1.25～1.30 alcohol-extracted extract with extracting the remaining Pericarpium Citri Reticulatae in back and 50～150 parts of Calyx Seu Fructus Physaliss; Four, alcohol-extracted extract is put into deionized water for stirring, leaving standstill after 12 hours with filter paper or molecular weight is that 1000～2000 daltonian ultrafilter membranes filter water lotion, and it is 1.25～1.30 Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum that filtrate decompression is condensed into proportion; Five, Fructus Momordicae charantiae the water extracted immersing paste, Pericarpium Citri Reticulatae volatile oil and Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum are mixed, obtain blood-sugar lowering tcm drug.
2. the preparation method of a kind of blood-sugar lowering tcm drug according to claim 1, it is characterized in that in the step 5 Pericarpium Citri Reticulatae volatile oil with use cyclodextrin inclusion compound before Fructus Momordicae charantiae the water extracted immersing paste and Pericarpium Citri Reticulatae Calyx Seu Fructus Physalis extractum mix.
3. the preparation method of a kind of blood-sugar lowering tcm drug according to claim 1, the quality that it is characterized in that deionized water in the step 2 is 6～14 times of Fructus Momordicae charantiae decoction pieces.
4. the preparation method of a kind of blood-sugar lowering tcm drug according to claim 1, it is characterized in that will extracting in the step 3 the remaining Pericarpium Citri Reticulatae in back and 60～140 parts of Calyx Seu Fructus Physaliss, to put into mass concentration be to carry out alcohol extraction in 65～75% the alcoholic solution to reclaim until obtaining proportion with the reclaim under reduced pressure method to ethanol after 3 hours be 1.26～1.30 alcohol-extracted extract.
5. the preparation method of a kind of blood-sugar lowering tcm drug according to claim 1, the quality that it is characterized in that deionized water in the step 4 is 2～4 times of alcohol-extracted extract.
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| CN106266216A (en) * | 2016-08-31 | 2017-01-04 | 哈尔滨医科大学 | A kind of blood glucose caused for diabetes-alleviating raises and prevention and the Chinese medicine composition treating diabetes and application thereof |
| CN108432924A (en) * | 2018-06-08 | 2018-08-24 | 贵州玉屏展鸿茶叶有限公司 | A kind of health protection tea of prevention diabetes |
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Effective date of registration: 20190417 Address after: 222000 Jiangning Industrial City, Lianyungang Economic and Technological Development Zone, Jiangsu Province Patentee after: Kangyuan Pharmceutical Co., Ltd. Address before: 150086 Health Road 157, Nangang District, Harbin City, Heilongjiang Province Patentee before: Harbin Medical University |