CN100415276C - A Chinese traditional medicinal preparation for treatment of vitiligo - Google Patents

Abstract

This invention relates to a kind of Chinese traditional medicine product which is used to treat vitiligo. The raw materials of the medicine include Radix Gentianae, Dioscorea septemlobaThunb, Rhizoma atractylodis, Coix Seed, Fructus Psoraleae, Flastem Milkvetch Seed, FructusTribuli, Ledebouriella seseloides Wolff, Radix Rehmanniae, Angelica sinensis (Oliv.) Diels, DanshenRoot, Red paeony root, Amur Corktree Bark and Poria. The product in this invention has the efficacies of nourishing liver and kidney, activating blood and resolving petechia, coursing wind and activating venation, whiting and lubricating skin, as well as the efficacies of preventing and curing vitiligo. It is characterized in its definite curative effect, no toxic side effective, taking-convenient and inexpensive price.

Description

The leukodermic Chinese medicine preparation of a kind of treatment

Technical field

The present invention relates to the leukodermic Chinese medicine preparation of a kind of treatment, is that a kind of vitiligo for the treatment of is the Chinese patent medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Vitiligo is a kind of posteriority limitation depigmentation dermatosis.Go down with skin color, bleach, boundary distinctness, no conscious sympton are feature.The same with other pigment anomalies, leukodermic sickness rate is with area, the ethnic group colour of skin and different.The dark more people's sickness rate of general colour is high more, and prevalence is about 0.1～2% in the population of China.The men and women can fall ill until old every year from the newborn baby about equally, but is many with teenager, has data to show that age of onset is in the majority 10～30 years old group, accounts for 62.65% of sum, and women's age of onset was than male about 5 years ahead of time.

Leukodermic clinical manifestation is: the skin at any position all can take place, but good sending out in being subject to solar radiation and frictionally damage position, as facial area, cervical region, trunk and extremity etc.The inboard mucosa of lip, labia, glans penis and foreskin also can involve.Most of leukasmus is symmetrically distributed, also has part patient white macula to distribute along nerve segment.Skin lesion is a limitation depigmentation speckle, milky, from fingernail to the coin size, circular, ellipse or irregular type.White macula place hair also can bleach.In progressive stage, the decolouring speckle is divided a word with a hyphen at the end of a line to normal skin, and development is very fast, and isomorphic response is arranged, and promptly can form the secondary vitiligo after pressure, friction, the wound.

Can divide three types according to leukoderma scope and distribution: 1, the topical type skin lesion is confined to a position, can be divided into 1. segmental pattern again: skin lesion is pressed dermatomere and is distributed; 2. mucosa type: only involve mucosa.2, general hair style is the most common, shows as skin lesion and is distributed widely in body surface, can be divided into 1. homeliness type: skin lesion is dispersed in and is distributed in the body surface many places; 2. face acra type: skin lesion is distributed in face and far-end of limb; 3. mixed type: above-mentioned several various combinations form.As face acra type+segmental pattern etc.3, whole body type, whole skin all decolour fully or almost, also have hair to bleach.

Primary disease is equivalent to leucoderma, the vitiligo of the traditional Chinese medical science.Put down in writing as " General Treatise on the Cause and Symptoms of Diseases " leucoderma: " the leucoderma person, face and neck health skin and flesh complexion changed are white, and be different with meat, the pain of also not itching, the leucoderma of meaning." and for example " the Yizong Jinjian surgery heart shows " vitiligo record: " vitiligo is the face collar humorously, and the ailment said due to cold or exposure white point speckle even all over of fighting does not mutually have the pain of itching, and controls and should fully recover from an illness by the pathogenic wind expelling fat liquoring.”

The traditional Chinese medical science thinks that leukodermic morbidity is outer because experience ailment said due to cold or exposure, injury from falling down; Interior because of feelings will internal injury, hemorrhagic disorder and consumption of essence etc., these can make qi-blood disharmony, and obstruction of collaterals by blood stasis, deficiency of the liver and kindey lead to this disease.So the treatment of the traditional Chinese medical science is to be divided into disease types such as disharmony between QI and blood, retention of damp-heat in the interior, obstruction of collaterals by blood stasis, deficiency of the liver and kindey, stagnation of QI due to depression of the liver to carry out Coryza Treated by Syndrome Differentiation.The leukodermic method of western medical treatment is a lot, but great majority can only reach recent clinical effectiveness, and can not prevent recurrence, and has toxic and side effects in various degree.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the leukodermic Chinese medicine preparation of a kind of treatment, have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.5～6 parts of 1.5～6 parts of Semen Coicis of 1～4 part of Rhizoma Dioscoreae Septemlobae of Radix Gentianae

2.5～10 parts of 1.5～6 parts of stir-baked SEMEN PSORALEAE with salt solution of 1.5～6 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

2.5～10 parts of 1.5～6 parts of salt Semen Astragali Complanatis of 1.5～6 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

2.5～10 parts of 1.5～6 parts of wine Radix Salviae Miltiorrhizaes of 1.5～6 parts of Radix Paeoniae Rubra of Radix Rehmanniae

1～4 part in 1～4 part of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

The weight proportion of each raw material of optimization formula of the present invention is:

2.5～3.5 parts of 2.5～3.5 parts of Semen Coicis of 1.5～2.5 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

3～7 parts of 2.5～3.5 parts of stir-baked SEMEN PSORALEAE with salt solution of 2.5～3.5 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

3～7 parts of 2.5～3.5 parts of salt Semen Astragali Complanatis of 2.5～3.5 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

3～7 parts of 2.5～3.5 parts of wine Radix Salviae Miltiorrhizaes of 2.5～3.5 parts of Radix Paeoniae Rubra of Radix Rehmanniae

1.5～2.5 parts in 1.5～2.5 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

The weight proportion of each raw material of optimum formula of the present invention is:

3 parts of 3 parts of Semen Coicis of 2 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

5 parts of 3 parts of stir-baked SEMEN PSORALEAE with salt solution of 3 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

5 parts of 3 parts of salt Semen Astragali Complanatis of 3 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

5 parts of 3 parts of wine Radix Salviae Miltiorrhizaes of 3 parts of Radix Paeoniae Rubra of Radix Rehmanniae

2 parts in 2 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

Drug action mechanism among the present invention is as follows:

Radix Gentianae nature and flavor hardship, cold.Return liver, gallbladder meridian.Have eliminating pathogen in the liver gallbladder fire, the clear part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels is wet, relieving convulsion making eye bright, and the malaria protozoon is good for the stomach, the effect that protects the liver.Can treat that Liver Channel intenseness of heat, infantile convulsion are manic, encephalitis B, headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, the swollen skin infection of pain, scrotum swell and ache, pudendum pruritus due to damp pathogen, hypertension dizziness tinnitus, chest and hypochondrium, acute infectious hepatitis, cystitis, skin infection swell and ache etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 413rd page).

Rhizoma Dioscoreae Septemlobae nature and flavor hardship, flat.Return kidney, stomach warp.Have dampness removing go turbid, the effect of the blood stasis dispelling that dispels the wind.Can treat the gonorrhea nebulousurine, leukorrhagia, damp and hot sore, waist knee joint arthralgia pain etc.(the 271st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Rhizoma Atractylodis (parched) nature and flavor suffering, hardship, temperature.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, expelling wind and cold, the effect that makes eye bright.Can treat distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia etc.(the 127th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Semen Coicis nature and flavor are sweet, light, cool.Return spleen, stomach, lung meridian.Has the spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, the effect of clearing away heat and discharging pus.Can treat edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana etc.(the 309th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Stir-baked SEMEN PSORALEAE with salt solution nature and flavor suffering, hardship, temperature.Return kidney, spleen channel.Have kidney invigorating and YANG supporting, the controlling nocturnal emission with astringent drugs reducing urination, warming spleen and stopping diarrha, the effect of improving inspiration by invigorating kidney-QI.Can treat that osteosarcoma, neoplastic bone shift, leukopenia, hemorrhagic illness, vitiligo, the cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, frequent micturition, deficiency and coldness are breathed heavily and are coughed etc. behind the chemotherapy radiotherapy.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 714th page).

Salt Semen Astragali Complanati nature and flavor are sweet, temperature.Return liver, kidney channel.Has the temperature compensation Liver and kidney, controlling nocturnal emission with astringent drugs, reducing urination, the effect that makes eye bright.Can treat lumbago due to renal deficiency, seminal emission premature ejaculation, nebulousurine leukorrhagia, dribbling urination, dizzy blurred vision etc.(the 145th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Stir-baked FRUCTUS TRIBULI nature and flavor suffering, hardship, tepor; Slightly poisonous.Return Liver Channel.Have the suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind makes eye bright, the itching relieving effect.It is dizzy to treat headache, distending pain in the chest and hypochondrium, and breast closes acute mastitis, conjunctival congestion cataracta, rubella pruritus etc.(the 289th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Radix Saposhnikoviae nature and flavor suffering, sweet, temperature.Return bladder, liver, spleen channel.Have inducing diaphoresis to dispel wind, win and wet, the effect of relieving convulsion.Can treat headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus etc.(the 117th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

The Radix Angelicae Sinensis (processed with wine) nature and flavor are sweet, hot, warm.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.Can be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea stimulates the menstrual flow, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, traumatic injury, ulcer sores etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 553rd page).

Wine Radix Salviae Miltiorrhizae nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Has stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Can treat menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris etc.(the 57th page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

Radix Paeoniae Rubra nature and flavor suffering, hardship, flavor are trembled with fear.Return Liver Channel.Has clearing away heat and cooling blood, the effect of eliminating stasis to stop pain.Can treat maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, traumatic injury, carbuncle skin infection etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 659th page).

Stir-baked CORTEX PHELLODENDRI with salt solution nature and flavor hardship, cold.Return kidney, urinary bladder channel.Have heat clearing and damp drying, pathogenic fire purging removes steams, and the effect of skin ulcer is treated in detoxifcation.Can treat damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.The stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.Can treat hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency etc.(the 251st page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The Poria nature and flavor are sweet, flat, light.GUIXIN, lung, spleen, kidney channel.Has eliminating dampness and diuresis, the effect of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Can treat that dysuria, edema distension, phlegm retention cough with dyspnea, brain are throbbed with fear, have loose bowels in the loose stool, irritability, palpitation with fear, insomnia, forgetful, seminal emission, stranguria with turbid discharge, insufficiency of the spleen, stop that drink is not eaten, gastral cavity is vexed, three YIN malaria (malaria pathogen in three YIN) disease, heating do not heal, end empty YANG-depletion etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 898th page).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", with Radix Gentianae, Rhizoma Dioscoreae Septemlobae, stir-baked SEMEN PSORALEAE with salt solution and salt Semen Astragali Complanati is monarch drug, Rhizoma Atractylodis (parched), Semen Coicis, stir-baked FRUCTUS TRIBULI, Radix Saposhnikoviae, Radix Rehmanniae, Radix Angelicae Sinensis (processed with wine), wine Radix Salviae Miltiorrhizae and Radix Paeoniae Rubra are ministerial drug, and stir-baked CORTEX PHELLODENDRI with salt solution and Poria are adjuvant.All medicines has mutually and altogether that nourishing the liver and kidney, blood circulation promoting and blood stasis dispelling, dispelling wind are active, the effect of the white and moist skin that disappears, treatment and prevention vitiligo, and determined curative effect has no side effect, and taking convenience is cheap.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose family and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, buccal tablet granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: tablet, capsule, oral liquid, buccal tablet, granule, electuary, pill, powder, suspensoid, powder, solution, drop, drop pill.Preferred Chinese medicine preparation is capsule, tablet, granule.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment and the prevention vitiligo of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through animal acute toxicity experiment the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, the present invention need not decoct, no bitterness sense, rich in proteins in the medicine, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid, also contain various trace elements such as Saponin, plant sterol and calcium, be beneficial to absorption of human body, health invigorating, and taking convenience.

3, the present invention not only can effectively treat vitiligo, and leukodermic prevention is also had good effect, has improved patient's life quality greatly, and higher healing rehabilitation efficacy is arranged.

Further specify medicine of the present invention to treatment therapy for vitiligo effect below by the clinical practice example.

Vitiligo curative effect determinate standard (the 228th page of Chen Qin chief editor " research and development of Chinese medicine cosmetic health product " Chinese Medicine science and technology publishing house version in 1999.)

(1) recovery from illness: the white macula complete obiteration, histopathology of skin checks normal.

(2) produce effects: white macula disappears more than 50%, and white macula disappearance portion of tissue pathological examination is normal.

(3) effective: white macula disappearance person accounts for 20%～50% of former white macula area, or sees have than the polychrom island in white macula.

(4) invalid: no change or white macula enlarge before and after the treatment.

As follows through clinical test results; Treatment patients with vitiligo 112 examples, male's 54 examples, women's 58 examples, the age is 12～55 years old.Take embodiment 1 capsule, each 2-10 grain, every day three to four times, eliminating cold for resuscitation water send down, and take half an hour ante cibum.Two months is a course of treatment, take continuously three the course of treatment observe the curative effect.84 examples of fully recovering account for 75%, and produce effects 19 examples account for 16.9%, and effective 7 examples account for 6.3%, and invalid 2 routine total effective rates reach more than 98%.After three course of therapy, the patient skin white macula disappears in various degree or fully recovers.And patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

Embodiment 1 capsule takes by weighing raw material by following weight:

6 parts of 6 parts of Semen Coicis of 4 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

10 parts of 6 parts of stir-baked SEMEN PSORALEAE with salt solution of 6 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

10 parts of 6 parts of salt Semen Astragali Complanatis of 6 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

10 parts of 6 parts of wine Radix Salviae Miltiorrhizaes of 6 parts of Radix Paeoniae Rubra of Radix Rehmanniae

4 parts in 4 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

Preparation method is to get Radix Gentianae Rhizoma Dioscoreae Septemlobae, Rhizoma Atractylodis (parched), Semen Coicis, stir-baked SEMEN PSORALEAE with salt solution, the salt Semen Astragali Complanati, stir-baked FRUCTUS TRIBULI, Radix Saposhnikoviae, Radix Rehmanniae, Radix Angelicae Sinensis (processed with wine), the wine Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, stir-baked CORTEX PHELLODENDRI with salt solution and Poria decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, incapsulates.Adorn 0.3 gram for every, usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, two months is a course of treatment.

Embodiment 2 tablets take by weighing raw material by following weight:

2 parts of 2 parts of Semen Coicis of 1 part of Rhizoma Dioscoreae Septemlobae of Radix Gentianae

3 parts of 2 parts of stir-baked SEMEN PSORALEAE with salt solution of 2 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

3 parts of 2 parts of salt Semen Astragali Complanatis of 2 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

3 parts of 2 parts of wine Radix Salviae Miltiorrhizaes of 2 parts of Radix Paeoniae Rubra of Radix Rehmanniae

1 part in 1 part of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

Preparation method is to get Radix Gentianae Rhizoma Dioscoreae Septemlobae, Rhizoma Atractylodis (parched), Semen Coicis, stir-baked SEMEN PSORALEAE with salt solution, the salt Semen Astragali Complanati, stir-baked FRUCTUS TRIBULI, Radix Saposhnikoviae, Radix Rehmanniae, Radix Angelicae Sinensis (processed with wine), the wine Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, stir-baked CORTEX PHELLODENDRI with salt solution and Poria decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, the clear paste of relative density 1.08～1.10, adding ethanol makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when spending, 50 degree～55 are concentrated into the clear paste of relative density 1.30～1.32, drying is ground into fine powder, adds appropriate amount of starch, alcohol granulation, after the drying, add an amount of magnesium stearate, tabletting, sugar coating are promptly.Usually half an hour ante cibum oral, eliminating cold for resuscitation water send down, one time 2～10, three to four times on the one, two months is a course of treatment.

Embodiment 3 granules take by weighing raw material by following weight:

3 parts of 3 parts of Semen Coicis of 2 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

5 parts of 3 parts of stir-baked SEMEN PSORALEAE with salt solution of 3 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

5 parts of 3 parts of salt Semen Astragali Complanatis of 3 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

5 parts of 3 parts of wine Radix Salviae Miltiorrhizaes of 3 parts of Radix Paeoniae Rubra of Radix Rehmanniae

2 parts in 2 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution

Preparation method is to get Radix Gentianae Rhizoma Dioscoreae Septemlobae, Rhizoma Atractylodis (parched), Semen Coicis, stir-baked SEMEN PSORALEAE with salt solution, the salt Semen Astragali Complanati, stir-baked FRUCTUS TRIBULI, Radix Saposhnikoviae, Radix Rehmanniae, Radix Angelicae Sinensis (processed with wine), the wine Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, stir-baked CORTEX PHELLODENDRI with salt solution and Poria decoct with water twice, 1.5～2 hours for the first time, 0.5～1 hour for the second time, merge decocting liquid twice, filter, filtrate is concentrated into 80 degree～85 when spending, and the clear paste of relative density 1.08～1.10 adds ethanol and makes clear paste contain the alcohol amount to reach 70%, left standstill 24 hours, reclaim ethanol, when 50 degree～55 are spent, be concentrated into the clear paste of relative density 1.30～1.32, drying, be ground into fine powder, add an amount of sucrose and soluble starch, alcohol granulation, the pack of dry back is promptly.Usually half an hour ante cibum warm boiled water, one time 1～3 bag, three to four times on the one, two months is a course of treatment.

Claims (3)

1. leukodermic Chinese medicine preparation of treatment is characterized in that it is made by following raw materials by weight proportions:

1.5～6 parts of 1.5～6 parts of Semen Coicis of 1～4 part of Rhizoma Dioscoreae Septemlobae of Radix Gentianae

2.5～10 parts of 1.5～6 parts of stir-baked SEMEN PSORALEAE with salt solution of 1.5～6 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

2.5～10 parts of 1.5～6 parts of salt Semen Astragali Complanatis of 1.5～6 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

2.5～10 parts of 1.5～6 parts of wine Radix Salviae Miltiorrhizaes of 1.5～6 parts of Radix Paeoniae Rubra of Radix Rehmanniae

1～4 part in 1～4 part of Poria of stir-baked CORTEX PHELLODENDRI with salt solution.

2. the leukodermic Chinese medicine preparation of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:

2.5～3.5 parts of 2.5～3.5 parts of Semen Coicis of 1.5～2.5 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

3～7 parts of 2.5～3.5 parts of stir-baked SEMEN PSORALEAE with salt solution of 2.5～3.5 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

3～7 parts of 2.5～3.5 parts of salt Semen Astragali Complanatis of 2.5～3.5 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

3～7 parts of 2.5～3.5 parts of wine Radix Salviae Miltiorrhizaes of 2.5～3.5 parts of Radix Paeoniae Rubra of Radix Rehmanniae

1.5～2.5 parts in 1.5～2.5 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution.

3. the leukodermic Chinese medicine preparation of a kind of treatment according to claim 1, wherein the weight proportion of each crude drug is:

3 parts of 3 parts of Semen Coicis of 2 parts of Rhizoma Dioscoreae Septemlobaes of Radix Gentianae

5 parts of 3 parts of stir-baked SEMEN PSORALEAE with salt solution of 3 parts of Radix Saposhnikoviaes of Rhizoma Atractylodis (parched)

5 parts of 3 parts of salt Semen Astragali Complanatis of 3 parts of Radix Angelicae Sinensis (processed with wine) of stir-baked FRUCTUS TRIBULI

5 parts of 3 parts of wine Radix Salviae Miltiorrhizaes of 3 parts of Radix Paeoniae Rubra of Radix Rehmanniae

2 parts in 2 parts of Poria of stir-baked CORTEX PHELLODENDRI with salt solution.