CN100546617C - A kind of traditional Chinese medicine preparation for treating tubal obstructive infertility - Google Patents

Abstract

The invention relates to a traditional Chinese medicine preparation for treating fallopian tube obstructive infertility. Fried cumin and lychee cores are used as ingredients. It has the effects of dispelling blood and promoting blood stasis, softening and resolving hard masses, searching wind and dredging collaterals, dispelling cold and relieving pain. The curative effect of treating tubal obstructive infertility is definite, without toxic and side effects, convenient to take, and low in price.

Description

A kind of traditional Chinese medicine preparation for treating tubal obstructive infertility

technical field

The invention relates to a traditional Chinese medicine preparation for treating tubal obstructive infertility, which is a Chinese patent medicine which uses Chinese herbal medicine as a raw material for treating tubal obstructive infertility. It belongs to the field of traditional Chinese medicine.

Background technique

The fallopian tube is not only a channel connecting the ovaries and the uterus, but also a place for ovulation, egg storage, and insemination, providing a place for the combination of sperm and eggs, and has the function of transporting pregnant eggs to the uterine cavity so as to reach the endometrium in time. Due to certain reasons, the fallopian tubes are blocked, and the function of transferring eggs and other dysfunctions affects the combination of eggs and sperm, resulting in infertility, which is called tubal obstructive infertility. According to statistics, among women suffering from infertility, cases of obstructive fallopian tubes account for more than 20%.

This disease belongs to the disease categories of "no child", "intermittent" and "irregular menstruation" in traditional Chinese medicine. Traditional Chinese medicine treats this disease with methods such as promoting blood circulation and removing blood stasis, softening hard masses and resolving stagnation. Traditional Chinese medicine believes that the formation of a lump in the abdomen is mostly due to the emptiness of the veins, external stagnation, or internal injury to the seven emotions, disordered qi and blood, or cold diet, abnormal rise and fall of qi, loss of circulation of qi, stagnation of blood as stasis, blocking the channels, or Invisible and accumulated, so the pathogenesis of tubal obstructive infertility should be Qi stagnation and blood stasis. Its clinical manifestations are often emotional depression, breast distension before menstruation, lower abdominal distension and pain before menstruation, lumps during menstruation, and soreness in the waist and spine, etc., and most of them are empirical.

There are many reasons for tubal obstruction, but the common causes are tubal endometriosis, salpingitis, and tubal dysfunction. The treatment methods include tubal ventilation, tubal fluid, and surgical correction of fallopian tubes. These methods have certain curative effects but also have certain limitations.

Contents of the invention

The present invention is developed on the basis of traditional Chinese medicine syndrome differentiation and treatment combined with the latest modern scientific research achievements. The object of the invention is to provide a traditional Chinese medicine preparation for treating tubal obstructive infertility. It has the characteristics of definite curative effect, safety and convenience, no toxic and side effects, and low price.

The present invention is made up of the raw material of following weight ratio:

Vinegar pangolin 0.1～2 parts Wine dodder 1.5～6 parts Saponaria thorn 0.1～1 part

Stir-fried King Buliu Xing 0.1~2 parts Vinegar and Myrrh 0.1~2 parts Peach Kernel 0.1~2 parts

Raw oyster 1.5~6 parts Smilax 0.1~2 parts Safflower 0.1~2 parts

Stir-fried fennel 0.1~1 part Lychee core 0.1~2 part

The weight proportion of each raw material of preferred formula of the present invention is:

Vinegar pangolin 0.5～1.5 parts Wine dodder 2.5～3.5 parts Saponaria thorn 0.3～0.7 parts

Stir-Fried King Bu Liu Xing 0.5～1.5 parts Vinegar Myrrh 0.5～1.5 parts Peach Kernel 0.5～1.5 parts

Raw oyster 2.5～3.5 parts Smilax 0.5～1.5 parts Safflower 0.5～1.5 parts

Stir-fried fennel 0.3～0.7 parts Lychee core 0.5～1.5 parts

The weight proportion of each raw material of optimum formula of the present invention is:

Vinegar pangolin 1 part Wine dodder 3 parts Saponaria thorn 0.5 part

Stir-fried King Buliu Xing 1 serving Vinegar and Myrrh 1 serving Peach Kernel 1 serving

3 parts raw oysters 1 part Smilax cocos 1 part safflower

Fried fennel 0.5 parts Lychee core 1 part

Drug mechanism among the present invention is as follows:

Vinegar pangolin is salty, cool and slightly cold. Return liver, stomach warp. It has the effects of reducing swelling and evacuating pus, dredging collaterals and lowering milk, promoting blood circulation and relieving pain, and eliminating stagnation. It can treat carbuncle, swollen and sore at the beginning, pus has not yet burst, milk blockage, wind-cold-damp arthralgia, amenorrhea, malnutrition abdominal pain, indigestion, traumatic bleeding, hematuria, cervical lymphatic tuberculosis, etc. (Ji Yubin editor-in-chief "Pharmacology and Application of Anticancer Traditional Chinese Medicine" Heilongjiang Science and Technology Press, 1999 edition, page 956).

The wine dodder is pungent, sweet, warm and flat in nature and flavor. Return liver, kidney, spleen channel. It has the effects of nourishing the liver and kidney, benefiting the essence, improving eyesight and improving essence. It can treat soreness of the waist and knees, impotence, nocturnal emission, thirst, urination, dark eyes, dizziness, vision loss, restless fetal movement, frequent urination, etc. (Ji Yubin editor-in-chief "Pharmacology and Application of Anticancer Traditional Chinese Medicine" Heilongjiang Science and Technology Press, 1999 edition, page 956).

Glycyrrhiza saponins are pungent and warm in taste. Return lung, stomach, large intestine channel. It has the effects of searching for wind, pulling out toxins, reducing swelling and draining pus. It can treat carbuncle, sore, ringworm, retained placenta, etc. (Ji Yubin editor-in-chief "Pharmacology and Application of Anticancer Traditional Chinese Medicine" Heilongjiang Science and Technology Press, 1999 edition, page 697).

Chao Wang Bu Liu Xing is bitter and flat in nature and taste. Return liver, stomach warp. It has the effects of promoting blood circulation and promoting menstruation, reducing breast swelling. It can treat breast milk retention, amenorrhea, dysmenorrhea, dystocia, bloody, bloody belt, black belt, mastitis, mastitis swelling and pain, gold sore bleeding, accumulation of lumps, bruises, stasis, urination, arthralgia, etc. . (Edited by Ji Yubin, "Anticancer Chinese Medicine Pharmacology and Application", Heilongjiang Science and Technology Press, 1999 edition, page 238).

Vinegar Myrrh is pungent in nature and flavor, bitter, flat. Return liver channel. It has the effects of dispersing blood and removing blood stasis, reducing swelling and relieving pain. It can treat bruises, gold sores, broken muscles and bones, various pains in trusted subordinates, lumps in the abdomen, amenorrhea, carbuncle swelling and pain, hemorrhoids, visual impairment, etc. (Edited by Ji Yubin, "Anti-cancer Chinese Medicine Pharmacology and Application", Heilongjiang Science and Technology Press, 1999 edition, page 708).

Peach kernel is bitter, sweet and flat in nature and flavor. GUIXIN, liver, large intestine channel. It has the effects of dispelling blood and promoting blood stasis, moistening intestines and laxative. It can cure amenorrhea, dysmenorrhea, lump in the abdomen, febrile blood accumulation, wind arthralgia, malaria, bruises, blood stasis, swelling and pain, blood dryness and constipation. (Edited by Ji Zibin, "Anticancer Chinese Medicine Pharmacology and Application", Heilongjiang Science and Technology Press, 1999 edition, page 708).

Raw oysters are salty and slightly cold. Return liver, gallbladder, kidney channel. It has the effects of calming the nerves, subduing yang and tonifying yin, softening hard masses and dispelling stagnation, astringent and astringent. It can be used for palpitations and insomnia, dizziness and tinnitus, scrofula with phlegm and cough, lumps in the abdomen, spontaneous sweating, nocturnal emission and metrorrhagia, stomach pain, pantothenic acid, etc. (Ji Yubin editor-in-chief "Pharmacology and Application of Anticancer Traditional Chinese Medicine" Heilongjiang Science and Technology Press, 1999 edition, page 674).

Smilax tuckahoe nature and flavor are sweet, light, flat. Return liver, stomach warp. It has the effects of clearing away heat and detoxification, dispelling rheumatism, strengthening bones and muscles, sharpening joints and fighting cancer. It can treat damp-heat sores, eczema, rheumatic bone pain, limb spasms, red bayberry sores, urinary system infections, syphilis, stranguria, leucorrhea, indigestion, diarrhea, beriberi, boils, carbuncles, scrofula, etc. (Edited by Ji Yubin, "Anticancer Chinese Medicine Pharmacology and Application", Heilongjiang Science and Technology Press, 1999 edition, page 87).

Flos Carthami nature and flavor are pungent, warm. GUIXIN, Liver Channel. It has the effects of promoting blood circulation and promoting menstruation, dissipating blood stasis and relieving pain. It can treat amenorrhea, lumps in the abdomen, dystocia, stillbirth, postpartum lochia, pain due to blood stasis, carbuncle, bruising, etc.

(Ji Yubin editor-in-chief "Pharmacology and Application of Anticancer Traditional Chinese Medicine" Heilongjiang Science and Technology Press, 1999 edition, page 604).

Stir-fried fennel is spicy and warm. Return liver, kidney, spleen, stomach, urinary bladder channel. It has the effects of dispelling cold and relieving pain, regulating qi and harmonizing the stomach. It can treat stomach cold pain, cold colic abdominal pain, testicular partial fall pain, cold pain in the lower abdomen, abdominal pain, indigestion, lack of food, vomiting and diarrhea, testicular hydrocele, schistosomiasis, kidney deficiency, low back pain, vomiting, dry and wet beriberi, Asthma etc. (Ji Yubin editor-in-chief "Anticancer Chinese Medicine Pharmacology and Application", Heilongjiang Science and Technology Press, 1999 edition, page 206).

Lychee core is sweet and astringent, warm. Return liver, kidney channel. It has the effects of warming, regulating qi and relieving pain. It can treat epigastric pain, colic pain, blood tingling in women, etc. ("Dictionary of Chinese Medicine" p. 1616.)

The present invention follows the formula principle of "jun, minister and assistant envoy" in traditional Chinese medicine, using vinegar pangolin, wine dodder, saponins, fried buliu xing and vinegar myrrh as king; peach kernel, safflower, raw oyster and Smilax as minister; Fennel and lychee cores are used as assistants. The combination of all medicines has the effects of dispelling blood and promoting blood stasis, softening and resolving hard masses, searching wind and dredging collaterals, dispelling cold and relieving pain. The treatment for tubal obstructive infertility has the characteristics of definite curative effect, no toxic and side effects, convenient administration and low price.

The traditional Chinese medicine preparation of the present invention can add a pharmaceutically acceptable carrier when it is prepared into a medicament, and the pharmaceutically acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivatives, celluloses and derivatives thereof , alginate, gelatin, polyvinylpyrrolidone, glycerin, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactant, polyethylene glycol, cyclodextrin, β-cyclodextrin, phospholipid materials, kaolin , talcum powder, calcium stearate, magnesium stearate, etc.

The Chinese medicine preparation of the present invention can be any pharmaceutically acceptable dosage form, and these dosage forms include: tablet, sugar-coated tablet, film-coated tablet, enteric-coated tablet, capsule, hard capsule, soft capsule, oral liquid, Buccal tablets, granules, pills, powders, ointments, elixirs, suspensions, powders, solutions, injections, suppositories, ointments, plasters, creams, sprays, drops, patches.

The preparation of the present invention is preferably an oral dosage form such as: tablet, capsule, oral liquid, buccal tablet, granule, pill, powder, suspension, powder, solution, drop, drop pill. More preferred Chinese medicine preparations are capsules, tablets, and granules.

Clinical use result of medicine of the present invention shows, has following advantage:

1, each component of the Chinese herbal medicine that the present invention selects conforms to the regulation of the Drug Administration Law of the People's Republic of China, utilizes the comprehensive effect of various flavors of Chinese medicines to treat tubal obstructive infertility, and is nontoxic and harmless to human body. The animal acute toxicity test shows that the tested animals have no toxic reaction, and the main organs have no obvious changes, and the drug is safe and reliable.

2. The present invention does not need to be decocted and has no bitterness. The medicine is rich in protein, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamins, amino acids, saponins, phytosterols and calcium, etc. A variety of trace elements are beneficial to the body's absorption and physical fitness.

3. The present invention can not only effectively treat fallopian tube obstructive infertility, but also has a good effect on the prevention of fallopian tube obstructive infertility. The treatment of fallopian tube obstructive infertility has definite curative effect, no toxic and side effects, easy to take, and low price Inexpensive features.

The therapeutic effect of the medicine of the present invention on treating tubal obstructive infertility is further illustrated below through clinical application examples.

Diagnosis basis for tubal obstructive infertility: ①Women of childbearing age who have been married for more than 2 years, the couple lives together, the spouse has normal reproductive function, and those who do not conceive without contraception are called primary infertility. Those who have had a history of pregnancy and childbirth, followed by an interval of more than 2 years without contraception and have not become pregnant are called secondary infertility. ② Exclude congenital physiological defects and deformities of the reproductive system. (Dai Shen et al. "Diagnosis and Treatment Standards and Prescription Selection of Diseases and Syndromes of Traditional Chinese Medicine" People's Medical Publishing House, 2001 Edition, Page 447)

Evaluation criteria for the curative effect of tubal obstructive infertility: ① Cured: those who conceive within 2 years. ② Improvement: Although not pregnant, the symptoms, signs and laboratory tests related to the disease have improved. ③ Unhealed: no improvement in symptoms, signs and laboratory tests. (Dai Shen et al. "Diagnosis and Treatment Standards and Prescription Selection of Diseases and Syndromes of Traditional Chinese Medicine" People's Health Publishing House, 2001 Edition, Page 453)

In order to show the therapeutic effect of the medicine of the present invention on treating tubal obstructive infertility, the clinical test results are as follows: 24 patients with tubal obstructive infertility were treated, aged 25 to 42 years. Take the granules of Example 3, each 1 to 3 bags, three to four times a day, take it with boiling water, and take it half an hour before meals. Three months is a course of treatment, and four courses of treatment are taken continuously to observe the curative effect. 15 cases were cured, accounting for 62.5%, 7 cases were improved, accounting for 29.1%, and 2 cases were not cured, accounting for 8.3%. The total effective rate was over 91%. After four courses of treatment, the patient had no adverse reactions, and no abnormalities were found in the three major routine tests and liver and kidney function tests.

Detailed ways

Embodiment 1 capsule takes raw material by following weight:

Vinegar pangolin 1 part Wine dodder 3 parts Saponaria thorn 0.5 part

Stir-fried Wang Bu Liu Xing 1 part Vinegar and Myrrh 1 part Peach Kernel 1 part

Raw oysters 3 parts Smilax 1 part Safflower 1 part

Fried cumin 0.5 part Lychee core 1 part

The preparation method is to firstly take vinegar pangolin and fried fennel, dry and pulverize them to 120-200 mesh fine powder, then take wine dodder, saponin thorn, fried wangbuliuxing, vinegar myrrh, peach kernel, safflower, raw oyster, smilax cocos and Add water to decoct the lychee core twice, the first time is 1.5-2 hours, and the second time is 0.5-1 hour. Combine the two decoctions, filter, and when the filtrate is concentrated to 80-85 degrees, the relative density is 1.08-1.10. paste, add ethanol to make the clear paste alcohol content reach 70%, let it stand for 24 hours, recover the ethanol, concentrate it to the clear paste with a relative density of 1.30-1.32 at 50-55 degrees, and then mix the clear paste with vinegar pangolin and stir-fry small Fennel fine powder is mixed, dried, crushed into fine powder, and packed into capsules. Each capsule contains 0.3 grams, usually taken orally half an hour before meals, given with warm water, 2 to 10 capsules at a time, three to four times a day, three months as a course of treatment.

Embodiment 2 tablet takes raw material by following weight:

Vinegar pangolin 1 part Wine dodder 3 parts Saponaria thorn 0.5 part

Stir-fried Wang Bu Liu Xing 1 part Vinegar and Myrrh 1 part Peach Kernel 1 part

Raw oysters 3 parts Smilax 1 part Safflower 1 part

Fried cumin 0.5 part Lychee core 1 part

The preparation method is to firstly take vinegar pangolin and fried fennel, dry and pulverize them to 120-200 mesh fine powder, then take wine dodder, saponin thorn, fried wangbuliuxing, vinegar myrrh, peach kernel, safflower, raw oyster, smilax cocos and Add water to decoct the lychee core twice, the first time is 1.5-2 hours, and the second time is 0.5-1 hour. Combine the two decoctions, filter, and when the filtrate is concentrated to 80-85 degrees, the relative density is 1.08-1.10. paste, add ethanol to make the clear paste alcohol content reach 70%, let it stand for 24 hours, recover the ethanol, concentrate it to the clear paste with a relative density of 1.30-1.32 at 50-55 degrees, and then mix the clear paste with vinegar pangolin and stir-fry small Fine fennel powder is mixed, dried, crushed into fine powder, added appropriate amount of starch and ethanol to granulate, after drying, added appropriate amount of magnesium stearate, pressed into tablets, coated with sugar to obtain. Usually take it orally half an hour before meals, take it with warm boiled water, 2 to 10 tablets at a time, three to four times a day, three months as a course of treatment.

Embodiment 3 granule takes raw material by following weight:

Vinegar pangolin 1 part Wine dodder 3 parts Saponaria thorn 0.5 part

Stir-fried Wang Bu Liu Xing 1 part Vinegar and Myrrh 1 part Peach Kernel 1 part

Raw oysters 3 parts Smilax 1 part Safflower 1 part

Fried cumin 0.5 part Lychee core 1 part

The preparation method is to firstly take vinegar pangolin and fried fennel, dry and pulverize them to 120-200 mesh fine powder, then take wine dodder, saponin thorn, fried wangbuliuxing, vinegar myrrh, peach kernel, safflower, raw oyster, smilax cocos and Add water to decoct the lychee core twice, the first time is 1.5-2 hours, and the second time is 0.5-1 hour. Combine the two decoctions, filter, and when the filtrate is concentrated to 80-85 degrees, the relative density is 1.08-1.10. paste, add ethanol to make the clear paste alcohol content reach 70%, let it stand for 24 hours, recover the ethanol, concentrate it to the clear paste with a relative density of 1.30-1.32 at 50-55 degrees, and then mix the clear paste with vinegar pangolin and stir-fry small Fine fennel powder is mixed, dried, crushed into fine powder, added with appropriate amount of sucrose and soluble starch, granulated with ethanol, dried and packed into bags. Usually take it with warm water half an hour before meals, 1 to 3 bags at a time, three to four times a day, three months as a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of oviduct obstructive sterility is characterized in that it is made by following raw materials by weight proportions:

0.1～1 part of 1.5～6 parts of Spina Gleditsiae of 0.1～2 part of Semen Cuscutae (processed with wine) of vinegar Squama Manis

0.1～2 part in 0.1～2 part of Semen Persicae of 0.1～2 part of Myrrha (processed with vinegar) of Semen Vaccariae (parched)

0.1～2 part on 0.1～2 part of Flos Carthami of 1.5～6 parts of Rhizoma Smilacis Glabraes of Concha Ostreae

0.1～2 part of 0.1～1 part of Semen Litchi of Fructus Foeniculi (parched).

2, a kind of Chinese medicine preparation for the treatment of oviduct obstructive sterility according to claim 1, wherein the weight proportion of each crude drug is:

0.3～0.7 part of 2.5～3.5 parts of Spina Gleditsiae of 0.5～1.5 part of Semen Cuscutae (processed with wine) of vinegar Squama Manis

0.5～1.5 part in 0.5～1.5 part of Semen Persicae of 0.5～1.5 part of Myrrha (processed with vinegar) of Semen Vaccariae (parched)

0.5～1.5 part on 0.5～1.5 part of Flos Carthami of 2.5～3.5 parts of Rhizoma Smilacis Glabraes of Concha Ostreae

0.5～1.5 part of 0.3～0.7 part of Semen Litchi of Fructus Foeniculi (parched).

3, a kind of Chinese medicine preparation for the treatment of oviduct obstructive sterility according to claim 1, wherein the weight proportion of each crude drug is:

0.5 part of 3 parts of Spina Gleditsiae of 1 part of Semen Cuscutae (processed with wine) of vinegar Squama Manis

1 part in 1 part of Semen Persicae of 1 part of Myrrha (processed with vinegar) of Semen Vaccariae (parched)

1 part on 1 part of Flos Carthami of 3 parts of Rhizoma Smilacis Glabraes of Concha Ostreae

1 part of 0.5 part of Semen Litchi of Fructus Foeniculi (parched).