CN113797298A

CN113797298A - Traditional Chinese medicine preparation for chronic hepatitis, preparation method and taking method thereof

Info

Publication number: CN113797298A
Application number: CN202111300605.9A
Authority: CN
Inventors: 蒋盛军; 蓝保强; 潘东; 盘叶花; 童远明; 赖克道; 李力
Original assignee: Guangxi Institute Of Chinese Medicine & Pharmaceutical Science
Current assignee: Guangxi Institute Of Chinese Medicine & Pharmaceutical Science
Priority date: 2021-11-04
Filing date: 2021-11-04
Publication date: 2021-12-17

Abstract

The invention discloses a traditional Chinese medicine preparation for chronic hepatitis, a preparation method and an administration method thereof, the traditional Chinese medicine preparation comprises a first prescription consisting of medicines with the property of pungent, hot, pungent, warm and yang-strengthening and a second prescription consisting of medicines with the property of bitter and cold, cool and slippery diarrhea or acid convergence, and the time range of the first prescription for the first administration is as follows: the time range of the second administration of the first formulation is from 6 th to 9 th: time 11-13; the time range for the first administration of the second formula is as follows: the time range of the first administration of the second formula from 17 hours to 21 hours is as follows: the time interval between the second administration and the first administration is at least one hour between 21 hours and 24 hours, the yin-yang divided medicine time-sharing administration traditional Chinese medicine preparation for treating chronic hepatitis is prepared into two kinds of granule, the storage, the transportation and the administration are convenient, the medicine is suitable for large-scale popularization and application, and the medicine is taken by a patient once every night and one hour before sleep at night, so that the effect of treating chronic hepatitis is good.

Description

Traditional Chinese medicine preparation for chronic hepatitis, preparation method and taking method thereof

Technical Field

The invention relates to a traditional Chinese medicine for chronic hepatitis, belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for chronic hepatitis, a preparation method and an administration method thereof.

Background

Chronic hepatitis refers to liver necrosis and inflammation caused by different causes, and the course of disease lasts for more than 1-2 months, such as hepatitis virus infection (hepatitis B virus, hepatitis C virus), long-term drinking, and taking hepatotoxic drugs. Corresponding symptoms, signs and abnormal liver biochemical examination can exist clinically, and no obvious clinical symptoms exist, and only necrosis and inflammation of liver tissues exist. The course of the disease is fluctuating or continuously progressive, and if proper treatment is not carried out, part of patients can progress to cirrhosis and even liver cancer.

Chronic hepatitis, as a common disease, has seriously harmed the health of people in China for many years and greatly affects the quality of life of people. At present, the clinical treatment of hepatitis A, hepatitis B and hepatitis C generally adopts a western medicine method, but the western medicine method usually treats the symptoms and root causes, cannot fundamentally condition human viscera, and achieves the aim of fundamentally treating the hepatitis A, the hepatitis B and the hepatitis C. Moreover, the traditional Chinese medicine has higher cost, longer treatment course and great side effect, and brings huge suffering to a plurality of patients with liver diseases. Chronic hepatitis and early cirrhosis belong to the categories of symptoms of hypochondriac pain, jaundice, accumulation and the like in traditional Chinese medicine, and the pathological changes of the chronic hepatitis and the early cirrhosis are liver loss and diarrhea and liver and spleen diseases caused by emotional, food and toxin and other reasons.

The traditional Chinese medicine distinguishes 5 basic symptoms of liver depression and spleen deficiency, damp-heat middle-jiao stagnation, blood stasis and collaterals obstruction, liver and kidney yin deficiency and spleen and kidney yang deficiency, and clinically, patients with liver depression and spleen deficiency, damp-heat middle-jiao stagnation and blood stasis and collaterals obstruction are more. Because the current traditional Chinese medicine syndrome evolution law of the liver disease is not well known, the current traditional Chinese medicine preparation for treating the liver disease still has the defects of weak curative effect, slow effect and the like. The chronic hepatitis is a serious obstacle to the circulation of the viscera, which causes the circulation of qi and blood of the human body to go backwards, the five elements of the viscera gradually grow into the condition that the five elements of the viscera are mutually restrained, the qi and blood of the human body are gradually weakened, and finally the qi and blood of the viscera of the human body run to separate yin from yang, and finally the qi and blood are exhausted and died. At present, most of traditional Chinese medicine preparations for treating chronic hepatitis are yin-yang combined medicines.

For example, the invention patent declared by Guanan Men Hospital of Chinese academy of science in 2019: a traditional Chinese medicine composition for treating chronic hepatitis B and hepatitis B related compensatory cirrhosis and an application number is CN201910418102, wherein the composition comprises the following raw materials: astragalus root, oriental wormwood, baikal skullcap root, coptis root, phellodendron bark, zedoary, turtle shell, parched hawthorn fruit, white peony root, trumpet creeper, bran-parched white atractylodes rhizome, tuckahoe, bupleurum root, oldenlandia diffusa, at least one of plantain seed or six-powder, at least one of cassia twig or dried ginger, at least one of nutgrass galingale rhizome, szechwan chinaberry fruit, angelica or red sage root, at least one of raw oyster shell, inula flower or raw ochre, at least one of parched almond (bitter almond) or tangerine peel, at least one of Chinese yam, ginger magnolia bark or rhizoma pinellinae praeparata, at least one of wrinkled gianthyssop, fortune eupatorium herb or rhizoma atractylodis, at least one of parched medicated leaven or parched malt, and at least one of black pharbitis seed, white pharbitis seed, coix seed, Chinese lobelia herb or barbed skullcap herb. The Chinese medicinal composition can be prepared into tablets, granules, pills and the like. The Chinese medicinal composition has effects of invigorating qi and spleen, eliminating dampness and heat, removing toxic substance, dredging collaterals, removing blood stasis, and eliminating abdominal mass, and can be used for treating chronic hepatitis B and hepatitis B related compensatory liver cirrhosis. In this patent, yang-qi, Bai Zhu, E Zhu and yin-qi, herba Artemisiae Scopariae, Huang Qin, Huang Lian, etc. are used in combination. The yin-yang combined preparation is difficult to treat or adjust chronic hepatitis which is a disease with yin-yang separation.

Other experts believe that chronic hepatitis is an inflammation that requires nourishing yin to reduce pathogenic fire, and a small amount of pure negative medication is used for treatment. The Chinese medicinal formulae for treating hepatitis can be primarily divided into two categories, one is a pure yin medicament and the other is a cold and cool yin-nourishing medicament, and the patents are relatively few; the representative formula patents of the pure yin medicine are as follows: for example, patent application for Chenanfen in 2019: a Chinese medicinal preparation for treating viral hepatitis B and its preparation method are disclosed, with application number of CN201911393777, which comprises the following components: toad, oldenlandia diffusa, barbat skullcap, cordyceps, selfheal, costus root, gentian, desmodium, radix bupleuri and oriental wormwood. The materials are prepared by the steps of material preparation, crushing, mixing, weighing, subpackaging and the like. The composition has effects of clearing liver-fire, promoting diuresis, removing toxic substance, tonifying deficiency, and invigorating vital essence and qi, and can be used for treating viral hepatitis type B, liver cirrhosis, hepatic ascites, and hepatocarcinoma.

The medicine is an incorrect treatment idea, can be used for treating a few acute hepatitis, is beneficial to pure negative cold and cool medicine for chronic hepatitis, and has almost no possibility of curing.

According to the theory of dividing yin and yang into medicine for time-sharing administration of traditional Chinese medicine provided by Jiang Sheng military Boster, two formulas of yin and yang are developed to treat chronic hepatitis, the yang medicine is taken at yang, and the yin medicine is taken at yin, so that the state of five elements of yin and yang being restrained can be well reversed, the chronic hepatitis can be treated more effectively, and the toxic and side effects of taking a yin-yang combined medicine preparation or a single pure yin preparation can be avoided.

Disclosure of Invention

The invention mainly solves the technical problem of how to provide a traditional Chinese medicine preparation for yin-yang divided-drug time-sharing administration, which firstly uses yang-drugs to dispel cold and release exterior, eliminates exterior symptoms, then treats deficiency cold of spleen and stomach, dredges channels and collaterals, leads heart fire to enter the channels and collaterals of the spleen and the stomach, does not generate pathogenic heat of liver and gallbladder, simultaneously, the yang-drugs rise yang qi of the liver and the gallbladder, leads qi and blood of the liver and the gallbladder to be actively released in the daytime at yang, leads the nutritional ingredients of the liver and the gallbladder to be fully released and utilized, and leads toxic ingredients to be excreted through bile; the traditional Chinese medicine preparation for chronic hepatitis, which is taken at night, has the functions of nourishing yin, promoting the production of body fluid, nourishing yin, generating blood, replenishing water and generating wood, and protecting and nourishing liver by replenishing kidney yin, replenishing water and generating wood, and the preparation method and the taking method thereof.

In order to solve the technical problems, the invention adopts a technical scheme that: the traditional Chinese medicine preparation for chronic hepatitis comprises a first prescription consisting of medicines with the property of pungent, hot, pungent, warm and yang-strengthening and a second prescription consisting of medicines with the property of bitter and cold, cool and slippery diarrhea or acidic convergence, wherein the raw materials of active ingredients of the first prescription comprise the following components in percentage by mass:

10-60 parts of astragalus membranaceus, 10-30 parts of bighead atractylodes rhizome, 5-15 parts of cinnamon, 5-15 parts of cornu cervi degelatinatum, 5-15 parts of pseudo-ginseng, 5-15 parts of red ginseng, 10-30 parts of angelica sinensis, 5-15 parts of ligusticum wallichii, 5-15 parts of ephedra, 5-15 parts of fructus amomi, 15-30 parts of semen allii tuberosi, 15-30 parts of fructus psoraleae, 15-30 parts of herba epimedii, 15-30 parts of cistanche and 15-30 parts of morinda officinalis;

the second prescription comprises the following active ingredients in percentage by mass:

6-12 parts of fructus broussonetiae, 15-30 parts of radix rehmanniae, 15-30 parts of salted semen cuscutae, 15-30 parts of medlar, 15-30 parts of eucommia ulmoides, 10-30 parts of rhizoma polygonati, 10-30 parts of radix polygonati officinalis, 10-30 parts of fructus corni, 10-15 parts of fructus schizandrae, 10-30 parts of salvia miltiorrhiza, 0.1-1.0 part of bear gall powder, 5-15 parts of herb of common knotweed, 5-15 parts of paederia scandens, 5-15 parts of gynostemma pentaphylla, 10-30 parts of rhizoma fibraureae, 10-30 parts of cudrania root, 20-60 parts of oriental wormwood, 5-15 parts of endothelium corneum gigeriae galli, 10-30 parts of rhizoma alismatis, 10-30 parts of poria cocos, 5-15 parts of radix curcumae, 20-60 parts of malt, 20-60 parts of tortoise plastron and 10-30 parts of radix bupleuri.

In a preferred embodiment, the active ingredients of the first prescription comprise the following raw materials in percentage by mass:

60 parts of astragalus membranaceus, 30 parts of bighead atractylodes rhizome, 15 parts of cinnamon, 15 parts of cornu cervi degelatinatum, 15 parts of pseudo-ginseng, 15 parts of red ginseng, 30 parts of angelica sinensis, 15 parts of ligusticum wallichii, 15 parts of ephedra, 15 parts of fructus amomi, 30 parts of semen allii tuberosi, 30 parts of fructus psoraleae, 30 parts of herba epimedii, 30 parts of cistanche and 30 parts of morinda officinalis;

12 parts of fructus broussonetiae, 30 parts of radix rehmanniae, 30 parts of common dodder seed, 30 parts of medlar, 30 parts of eucommia bark, 30 parts of rhizoma polygonati, 30 parts of polygonatum, 30 parts of cornus officinalis, 15 parts of Chinese magnoliavine fruit, 30 parts of salvia miltiorrhiza, 1.0 part of bear gall powder, 15 parts of Chinese knotweed herb, 15 parts of Chinese fevervine herb, 15 parts of gynostemma pentaphylla, 30 parts of radix astragali, 30 parts of cudrania root, 60 parts of oriental wormwood, 15 parts of chicken's gizzard-membrane, 30 parts of rhizoma alismatis, 30 parts of poria cocos, 15 parts of radix curcumae, 60 parts of malt, 60 parts of tortoise plastron and 30 parts of radix bupleuri.

40 parts of astragalus membranaceus, 15 parts of bighead atractylodes rhizome, 10 parts of cinnamon, 10 parts of cornu cervi degelatinatum, 10 parts of pseudo-ginseng, 10 parts of red ginseng, 15 parts of angelica sinensis, 10 parts of ligusticum wallichii, 10 parts of ephedra, 10 parts of fructus amomi, 20 parts of semen allii tuberosi, 20 parts of fructus psoraleae, 20 parts of herba epimedii, 20 parts of cistanche and 20 parts of morinda officinalis;

9 parts of fructus broussonetiae, 20 parts of radix rehmanniae, 20 parts of salted semen cuscutae, 20 parts of medlar, 20 parts of eucommia ulmoides, 20 parts of rhizoma polygonati, 20 parts of radix polygonati officinalis, 20 parts of fructus corni, 10 parts of fructus schizandrae, 20 parts of radix salviae miltiorrhizae, 0.5 part of bear gall powder, 10 parts of herb of common knotweed, 10 parts of paederia scandens, 10 parts of gynostemma pentaphylla, 15 parts of radix astragali, 15 parts of cudrania root, 40 parts of oriental wormwood, 10 parts of endothelium corneum gigeriae galli, 15 parts of rhizoma alismatis, 15 parts of poria cocos, 10 parts of radix curcumae, 40 parts of malt, 40 parts of tortoise plastron and 15 parts of radix bupleuri.

10 parts of prepared monkshood, 10 parts of astragalus membranaceus, 10 parts of bighead atractylodes rhizome, 10 parts of cassia twig, 5 parts of cinnamon, 5 parts of cornu cervi degelatinatum, 5 parts of pseudo-ginseng, 5 parts of red ginseng, 10 parts of angelica sinensis, 5 parts of ligusticum wallichii, 10 parts of honey-fried licorice root, 5 parts of ephedra, 5 parts of fructus amomi, 15 parts of semen allii tuberosi, 15 parts of fructus psoraleae, 15 parts of herba epimedii, 15 parts of cistanche and 15 parts of morinda officinalis;

6 parts of fructus broussonetiae, 15 parts of radix rehmanniae, 15 parts of common dodder, 15 parts of medlar, 15 parts of eucommia ulmoides, 10 parts of rhizoma polygonati, 10 parts of radix polygonati officinalis, 10 parts of fructus corni, 10 parts of fructus schizandrae, 10 parts of radix salviae miltiorrhizae, 0.1 part of bear gall powder, 5 parts of herb of common knotweed, 5 parts of paederia scandens, 5 parts of gynostemma pentaphylla, 10 parts of radix astragali, 10 parts of cudrania root, 20 parts of oriental wormwood, 5 parts of endothelium corneum gigeriae galli, 10 parts of rhizoma alismatis, 10 parts of poria cocos, 5 parts of radix curcumae, 20 parts of malt, 20 parts of tortoise plastron and 10 parts of radix bupleuri.

A preparation method of a traditional Chinese medicine preparation for chronic hepatitis is used for preparing the traditional Chinese medicine preparation for chronic hepatitis, and the preparation method of the traditional Chinese medicine preparation for chronic hepatitis comprises the following steps:

s1, uniformly mixing the raw materials of the first prescription, adding water, heating and decocting to obtain a first prescription extracting solution;

s2, filtering the first prescription extract, concentrating, adding dextrin, drying at high temperature, granulating and sieving to obtain a first prescription granular preparation;

s3, uniformly mixing the raw materials of the second prescription, adding water, heating and decocting to obtain a second prescription extracting solution;

s4, filtering and concentrating the second prescription extract, adding dextrin, drying at high temperature, granulating and sieving to obtain a second prescription granular preparation;

in a preferred embodiment, the heating temperature is set to 80-100 ℃ in steps S1 and S3; the heating time is set to be 1-6 hours.

In a preferred embodiment, the steps S1 and S2 specifically include the following steps:

a1, adding 6 times of water into each raw material of the first preparation according to the weight of the formula of the traditional Chinese medicine preparation for chronic hepatitis;

b1, decocting the mixture obtained in the step A1 after water is added twice, wherein each time lasts for 1.5 hours;

c1, filtering the solution decocted in the step B1, and concentrating the solution into paste;

d1, adding dextrin into the pasty solution obtained in the step C1, and uniformly stirring;

e1, granulating and drying the mixture obtained in the step D1 to obtain a first prescription granule preparation.

In a preferred embodiment, the steps S3 and S4 specifically include the following steps:

adding 6 times of water according to the formula, decocting twice, each time for 1.5 hours, filtering the decoction, concentrating, adding dextrin when the filtrate is concentrated to a certain density, finally adding bear gall powder and amber powder, stirring, preparing into granules, and drying to obtain the yin medicine granules of the yin-yang divided medicine time-sharing administration preparation for treating chronic hepatitis.

A2, adding 6 times of water into the other raw materials except fel Ursi powder and Succinum powder according to the weight of the Chinese medicinal preparation for treating chronic hepatitis;

b2, decocting the mixture obtained in the step A2 after water is added twice, wherein each time lasts for 1.5 hours;

c2, filtering the solution decocted in the step B2, and concentrating the solution into paste;

d2, adding dextrin, bear gall powder and amber powder into the pasty solution obtained in the step C2, and uniformly stirring;

e2, granulating and drying the mixture obtained in the step D2 to obtain a second prescription granule preparation.

A method for taking a traditional Chinese medicine preparation for chronic hepatitis is used for taking the traditional Chinese medicine preparation for chronic hepatitis, and the method for taking the traditional Chinese medicine preparation for chronic hepatitis comprises the following steps: the first formulation is administered twice daily and the second formulation is administered twice daily.

In a preferred embodiment, the first dose is taken for a time period within the range of: the time range of the second administration of the first formulation is from 6 th to 9 th: time 11-13; the time range for the first administration of the second formula is as follows: the time range of the first administration of the second formula from 17 hours to 21 hours is as follows: the second formulation is administered at a time between 21 hours and 24 hours, separated from the time of the first administration by at least one hour.

The invention has the beneficial effects that: the second prescription for treating chronic hepatitis and the first prescription for treating chronic hepatitis are taken separately, so that the first prescription or the second prescription can exert the maximum drug effect, and the drug harm is avoided or reduced.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention is described in detail by the following examples:

example 1

A traditional Chinese medicine preparation for chronic hepatitis comprises a first prescription consisting of medicines with the property of pungent, hot, pungent, warm and yang-strengthening and a second prescription consisting of medicines with the property of bitter and cold, cool and slippery diarrhea or acidic convergence, wherein the first prescription comprises the following active ingredients in percentage by mass:

Example 2

A Chinese medicinal preparation for treating chronic hepatitis comprises a first prescription containing medicinal materials with pungent, hot, pungent, warm and yang-strengthening effects, and a second prescription containing medicinal materials with bitter and cold properties, or cooling and laxative or acidic astringent effects:

the effective components of the first prescription are calculated according to the mass percentage as follows:

Example 3

A Chinese medicinal preparation for treating chronic hepatitis comprises a first prescription containing medicinal materials with pungent, hot, pungent, warm and yang-tonifying effects, and a second prescription containing medicinal materials with bitter and cold properties, or cooling and laxative or acidic astringent effects.

Example 4

Example 5

in the steps S1 and S3, the heating temperature is set to be 80-100 ℃; the heating time is set to be 1-6 hours.

In step S1 and step S2, the method specifically includes the following steps:

In step S3 and step S4, the method specifically includes the following steps:

Example 6

Wherein, the time range of the first dose for the first time is as follows: the time range of the second administration of the first formulation is from 6 th to 9 th: time 11-13; the time range for the first administration of the second formula is as follows: the time range of the first administration of the second formula from 17 hours to 21 hours is as follows: the second formulation is administered at a time between 21 hours and 24 hours, separated from the time of the first administration by at least one hour.

Example 7

The Chinese medicinal preparation for treating chronic hepatitis is composed of a yang medicinal prescription of the Chinese medicinal preparation for treating chronic hepatitis, and a yin medicinal prescription of the Chinese medicinal preparation for treating chronic hepatitis, wherein the yang medicinal prescription is taken by dividing yin into yang medicinal components by time, and the yin medicinal prescription is taken by dividing yin into yang medicinal components by time, and is prepared from the following raw materials in parts by weight: 10-30 g of prepared monkshood, 10-60 g of astragalus membranaceus, 10-30 g of bighead atractylodes rhizome, 10-30 g of cassia twig, 5-15 g of cinnamon, 5-15 g of cornu cervi degelatinatum, 5-15 g of pseudo-ginseng, 5-15 g of red ginseng, 10-30 g of angelica sinensis, 5-15 g of ligusticum wallichii, 10-30 g of honey-fried licorice root, 5-15 g of ephedra, 5-15 g of fructus amomi, 15-30 g of semen allii tuberosi, 15-30 g of fructus psoraleae, 15-30 g of herba epimedii, 15-30 g of cistanche and 15-30 g of morinda officinalis;

the yin medicine prescription of the traditional Chinese medicine preparation which is taken by dividing yin and yang into medicines at different times for treating chronic hepatitis is prepared from the following raw materials in parts by weight: 6-12 g of fructus broussonetiae, 15-30 g of radix rehmanniae, 15-30 g of common dodder seed, 15-30 g of medlar, 15-30 g of eucommia bark, 10-30 g of rhizoma polygonati, 10-30 g of polygonatum odoratum, 10-30 g of cornus officinalis, 10-15 g of schisandra chinensis, 10-30 g of salvia miltiorrhiza, 0.1-1.0 g of bear gall powder, 5-15 g of herb of common knotweed, 5-15 g of Chinese fevervine herb, 5-15 g of gynostemma pentaphylla, 10-30 g of rhizoma fibraureae, 10-30 g of cudrania root, 20-60 g of oriental wormwood, 5-15 g of endothelium corneum gigeriae galli, 10-30 g of rhizoma alismatis, 10-30 g of poria cocos, 5-15 g of radix curcumae, 20-60 g of malt, 20-60 g of tortoise plastron and 10-30 g of radix bupleuri.

Example 8

A preparation method of a yang medicine prescription of a traditional Chinese medicine preparation for treating chronic hepatitis by dividing yin and yang into medicines and taking the medicines at different time comprises the following operation steps:

1) mixing the above materials, heating and decocting to obtain Chinese medicinal extractive solution;

2) filtering the serous fluid prepared in the step 1), concentrating, adding dextrin, drying at high temperature, granulating and sieving to obtain the yang medicine granule preparation of the traditional Chinese medicine preparation for treating chronic hepatitis by dividing the yin into the yang medicine and taking the yin into the yang medicine at different time;

the heating temperature in the step 1) is 80-100 ℃.

The heating time in the step 1) is 1-6 hours.

The preparation method of the yin medicine of the traditional Chinese medicine preparation for treating chronic hepatitis by dividing yin into medicine and yang into medicine portions comprises the following operation steps:

mixing the above materials, heating and decocting to obtain Chinese medicinal extractive solution;

filtering the serous fluid prepared in the step 1), concentrating, adding dextrin, drying at high temperature, granulating and sieving to obtain the yin-yang granule preparation for treating chronic hepatitis.

The heating temperature in the step 1) is 80-100 ℃.

The heating time in the step 1) is 1-6 hours.

Example 9

A method for preparing yang medicinal prescription granule of Chinese medicinal preparation for treating chronic hepatitis comprises mixing raw materials, heating, and decocting to obtain Chinese medicinal extractive solution; filtering the extractive solution, concentrating, adding dextrin, stirring, drying, and granulating to obtain granule of yang medicine for oral administration; mixing the above materials, heating and decocting to obtain Chinese medicinal extractive solution; filtering the extractive solution, concentrating, adding dextrin, stirring, drying, and granulating to obtain Chinese medicinal granule for treating chronic hepatitis.

Wherein the heating temperature is 80-100 ℃, the heating time is 1-6 hours, and the method also comprises the steps of filtering the traditional Chinese medicine extracting solution, concentrating, adding dextrin, drying and granulating.

The embodiment 8-9 of the invention relates to a preparation method of a yin-yang divided medicine and time-sharing taking preparation for treating chronic hepatitis, the yin-yang divided medicine and time-sharing taking traditional Chinese medicine preparation for treating chronic hepatitis is prepared into two kinds of granule, and the granule is convenient to store, transport and take and is suitable for large-scale popularization and application.

Example 10

The yang medicine taking time in the embodiment of the invention is as follows: taken before breakfast or lunch in the morning; administration time of yin herbs: the yin-nourishing herbs are taken once before dinner or one hour before sleep.

Example 11

The embodiment prepares the traditional Chinese medicine granules of the yang medicine prescription for taking the traditional Chinese medicine preparation at different time according to yin and yang medicine for treating chronic hepatitis. The prescription of the yang medicine for treating chronic hepatitis takes high-dose Chinese medicine preparation by dividing yin and yang into medicine and time-sharing:

30 g of prepared aconite, 60 g of astragalus, 30 g of bighead atractylodes rhizome, 30 g of cassia twig, 15 g of cinnamon, 15 g of cornu cervi degelatinatum, 15 g of pseudo-ginseng, 15 g of red ginseng, 30 g of angelica, 15 g of ligusticum wallichii, 30 g of honey-fried licorice root, 15 g of ephedra, 15 g of fructus amomi, 30 g of semen allii tuberosi, 30 g of fructus psoraleae, 30 g of herba epimedii, 30 g of cistanche and 30 g of morinda officinalis.

Adding 6 times of water according to the formula, decocting for two times, each time for 1.5 hours, filtering the decoction, concentrating, adding dextrin when the filtrate is concentrated to a certain density, stirring, preparing into granules, and drying to obtain the yang medicine granules of the yin-yang medicine time-sharing administration preparation for treating chronic hepatitis.

The composition is administered to patients once every morning and noon for treating chronic hepatitis.

The embodiment prepares the traditional Chinese medicine granules of the yin-yang prescription of the preparation for yin-yang divided-medicine time-sharing administration for treating chronic hepatitis. The yin-yang prescription for treating chronic hepatitis takes high-dose Chinese medicinal preparation by dividing yin and yang into different parts by time: 12 g of fructus broussonetiae, 30 g of radix rehmanniae, 30 g of common dodder seed, 30 g of medlar, 30 g of eucommia bark, 30 g of rhizoma polygonati, 30 g of polygonatum, 30 g of cornus officinalis, 15 g of schisandra chinensis, 30 g of salvia miltiorrhiza, 1.0 g of bear gall powder, 15 g of herb of common knotweed, 15 g of paederia scandens, 15 g of gynostemma pentaphylla, 30 g of rhizoma coptidis, 30 g of cudrania root, 60 g of oriental wormwood, 15 g of chicken's gizzard-membrane, 30 g of rhizoma alismatis, 30 g of poria cocos, 15 g of radix curcumae, 60 g of malt, 60 g of tortoise plastron and 30 g of radix bupleuri.

The composition is administered once every night and one hour before sleep to treat chronic hepatitis.

Example 12

The embodiment prepares the traditional Chinese medicine granules of the yang medicine prescription of the yin-yang medicine-divided time-sharing administration preparation for treating chronic hepatitis, and the yang medicine prescription of the yin-yang medicine-divided time-sharing administration medium-dose traditional Chinese medicine preparation for treating chronic hepatitis: 20 g of prepared aconite, 40 g of astragalus, 15 g of bighead atractylodes rhizome, 15 g of cassia twig, 10 g of cinnamon, 10 g of cornu cervi degelatinatum, 10 g of pseudo-ginseng, 10 g of red ginseng, 15 g of angelica, 10 g of ligusticum wallichii, 15 g of honey-fried licorice root, 10 g of ephedra, 10 g of fructus amomi, 20 g of semen allii tuberosi, 20 g of fructus psoraleae, 20 g of herba epimedii, 20 g of cistanche and 20 g of morinda officinalis.

The composition is administered once a day in the morning or at noon to treat chronic hepatitis.

The embodiment prepares the traditional Chinese medicine granules of the yin-yang prescription of the preparation for yin-yang divided-medicine time-sharing administration for treating chronic hepatitis. The yin-yang prescription for treating chronic hepatitis takes the Chinese medicinal preparation with medium dosage by dividing the yin and yang into different parts and time: 9 g of fructus broussonetiae, 20 g of radix rehmanniae, 20 g of common dodder seed, 20 g of medlar, 20 g of eucommia bark, 20 g of rhizoma polygonati, 20 g of radix polygonati officinalis, 20 g of cornus officinalis, 10 g of Chinese magnoliavine fruit, 20 g of salvia miltiorrhiza, 0.5 g of bear gall powder, 10 g of herb of common knotweed, 10 g of Chinese fevervine herb, 10 g of gynostemma pentaphylla, 15 g of rhizoma coptidis, 15 g of cudrania root, 40 g of oriental wormwood, 10 g of chicken's gizzard-membrane, 15 g of rhizoma alismatis, 15 g of poria cocos, 10 g of radix curcumae, 40 g of malt, 40 g of tortoise plastron and 15 g of radix bupleuri.

Adding 6 times of water according to the formula, decocting twice, each time for 1.5 hours, filtering the decoction, concentrating, adding dextrin when the filtrate is concentrated to a certain density, finally adding bear gall powder and amber powder, stirring, preparing into granules, and drying to obtain yin medicine granules of the yin-yang divided medicine time-sharing taking preparation for treating chronic hepatitis.

Example 13

The embodiment prepares the traditional Chinese medicine granules of the yang medicine prescription of the yin-yang medicine-divided time-sharing administration preparation for treating chronic hepatitis, and the yang medicine prescription of the yin-yang medicine-divided time-sharing administration low-dose traditional Chinese medicine preparation for treating chronic hepatitis:

10 g of prepared aconite, 10 g of astragalus, 10 g of white atractylodes rhizome, 10 g of cassia twig, 5 g of cinnamon, 5 g of cornu cervi degelatinatum, 5 g of pseudo-ginseng, 5 g of red ginseng, 10 g of angelica, 5 g of ligusticum wallichii, 10 g of honey-fried licorice root, 5 g of ephedra, 5 g of fructus amomi, 15 g of semen allii tuberosi, 15 g of fructus psoraleae, 15 g of herba epimedii, 15 g of cistanche and 15 g of morinda officinalis.

The embodiment prepares the traditional Chinese medicine granules of the yin-yang prescription of the preparation for yin-yang divided-medicine time-sharing administration for treating chronic hepatitis. The yin-yang prescription for treating chronic hepatitis takes low-dose Chinese medicinal preparation by dividing yin and yang into different parts by time: 6 g of fructus broussonetiae, 15 g of radix rehmanniae, 15 g of common dodder seed, 15 g of medlar, 15 g of eucommia bark, 10 g of rhizoma polygonati, 10 g of radix polygonati officinalis, 10 g of cornus officinalis, 10 g of schisandra chinensis, 10 g of salvia miltiorrhiza, 0.1 g of bear gall powder, 5 g of herb of common knotweed, 5 g of paederia scandens, 5 g of gynostemma pentaphylla, 10 g of rhizoma coptidis, 10 g of cudrania root, 20 g of oriental wormwood, 5 g of endothelium corneum gigeriae galli, 10 g of rhizoma alismatis, 10 g of poria cocos, 5 g of radix curcumae, 20 g of malt, 20 g of tortoise plastron and 10 g of radix bupleuri.

The functional brief introduction of each raw material medicine of the yang medicine prescription for taking the traditional Chinese medicine preparation in time-sharing by dividing yin and yang in the above examples 1-13:

(1) the processed Fu Zi is pungent, sweet, hot and toxic, and enters heart, kidney and spleen meridians; has effects in invigorating kidney, strengthening fire, restoring yang, relieving collapse, dispelling cold, and relieving pain; the main treatment is as follows: is suitable for treating yang deficiency, common cold, sexual impotence, cold womb, yang exhaustion, asthenia, cold pain of heart and abdomen, vomiting and diarrhea due to asthenia cold, and arthralgia due to cold-dampness.

(2) Radix astragali is sweet and warm; meridian tropism: lung and spleen meridians; the efficacy is as follows: invigorating qi, consolidating superficial resistance, inducing diuresis, relieving swelling, expelling pus, healing sore, and promoting granulation; the main treatment is as follows: deficiency of qi, asthenia, poor appetite, loose stool, collapse of middle-jiao energy, chronic diarrhea, rectocele, metrorrhagia, superficial deficiency, spontaneous perspiration, edema due to qi deficiency, carbuncle, cellulitis, intractable ulcer, blood deficiency, debility with yellowish complexion, internal heat, and diabetes; proteinuria due to chronic nephritis and diabetes.

(3) The property, flavor and channel tropism of white atractylodes rhizome: bitter, sweet and warm; it enters spleen and stomach meridians.

The efficacy of the white atractylodes rhizome is as follows: tonify qi and invigorate spleen, dry dampness and induce diuresis, stop sweating, prevent abortion.

The main treatment of the white atractylodes rhizome is as follows: can be used for treating spleen qi deficiency, anorexia, loose stool, phlegm retention, edema, exterior deficiency, spontaneous perspiration, and threatened abortion.

(4) The cassia twig is pungent, sweet and warm in flavor; the main functions are to relieve the muscles by sweating, warm and dredge the channels and collaterals, strengthen yang and regulate qi, and also have the functions of calming the Chong and descending qi; can be used for treating exterior syndrome due to wind-cold, cold-dampness pain caused by cold, cold limbs cold, amenorrhea, dysmenorrhea, gynecological lump, thoracic obstruction, cardialgia, cardiopalmus, phlegm and fluid retention, dysuria, etc.

(5) Cortex Cinnamomi

Nature, flavor and meridian tropism: big and hot in nature, pungent and sweet in flavor. It enters kidney, spleen, heart and liver meridians.

The efficacy and the effect are as follows: replenishing fire and supporting yang, guiding fire to return to original place, dispelling cold and relieving pain, and warming and dredging channels and collaterals; can be used for treating sexual impotence, cold womb, cold pain of waist and knee, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

(6) Property, flavor and meridian tropism of cornu cervi degelatinatum: salty and astringent taste, warm in nature; the liver and kidney meridians.

The efficacy and the main treatment are as follows: warming kidney and tonifying yang, astringing to stop bleeding, and can be used for treating spleen and kidney yang deficiency, leukorrhagia, enuresis, frequent micturition, metrorrhagia, metrostaxis, and unhealed sores and ulcers.

(7) The nature, flavor and meridian tropism of pseudo-ginseng: sweet, slightly bitter and warm. It enters heart, liver and spleen meridians.

The efficacy and the main treatment are as follows: removing blood stasis, stopping bleeding, relieving swelling and pain; can be used for treating internal and external hemorrhage, traumatic injury, and swelling and pain due to blood stasis.

(8) Ginseng, nature, taste and meridian tropism: warm in nature, sweet in taste, slightly bitter in taste, entering spleen, lung and heart meridians; the efficacy is as follows: invigorating primordial qi, restoring pulse, relieving depletion, invigorating qi, and regulating blood; the main treatment is as follows: can be used for treating asthenia, collapse, cold limbs, slight pulse, qi deficiency, blood disorder, metrorrhagia, and metrostaxis; heart failure, cardiogenic shock.

(9) The nature, flavor and meridian tropism of Chinese angelica: sweet, pungent and warm; it enters liver, heart and spleen meridians; the functional indications are as follows: enriching blood, promoting blood circulation, regulating menstruation, relieving pain, loosening bowel to relieve constipation; can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease.

(10) The nature, flavor and meridian tropism of the rhizome of chuanxiong: the rhizome of Sichuan lovage is pungent and warm; it enters liver, gallbladder and pericardium meridians. The efficacy of the hemlock parsley is as follows: promote blood circulation and move qi, dispel wind and alleviate pain. The main treatment of the rhizoma ligustici wallichii is as follows: can be used for treating menoxenia, hypochondriac pain, thoracic obstruction, pyocutaneous disease, swelling and pain, traumatic injury, headache, and rheumatalgia.

(11) Prepared licorice root, radix Glycyrrhizae Praeparata, having the property of flavor entering meridian: warm in nature and sweet in taste; the heart meridian, the lung meridian, the stomach meridian and the spleen meridian; the efficacy and the main treatment are as follows: invigorating spleen and regulating stomach function, benefiting qi and recovering pulse; the clinical application is as follows: can be used for treating weakness of spleen and stomach, asthenia, palpitation, and intermittent pulse.

(12) Ephedra herb is of a nature, flavor and meridian tropism: pungent and warm; entering heart, lung and kidney meridians; the functions and indications are as follows: relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging orifice, warming lung, and eliminating phlegm; can be used for treating common cold due to wind-cold, headache, toothache, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, rheumatic arthralgia, phlegm and fluid retention, and cough and asthma.

(13) Fructus amomi property, flavor and meridian tropism: pungent and warm. It enters spleen and stomach meridians.

The efficacy of fructus amomi: resolve dampness, move qi, warm middle energizer, prevent abortion.

The major indications of fructus amomi are as follows: can be used for treating damp obstruction, qi stagnation, abdominal distention and pain, anorexia, diarrhea due to cold-dampness, pernicious vomiting, and threatened abortion.

(14) Semen Allii Tuberosi is warm in nature, pungent and sweet in flavor. It enters kidney and liver meridians.

The efficacy and the main treatment are as follows: warming and nourishing liver and kidney, tonifying yang and arresting spontaneous emission; can be used for treating spermatorrhea, soreness of waist and knees, enuresis, frequent micturition, and leukorrhagia.

(15) Psoralea corylifolia with characteristic flavor entering meridians: pungent, bitter and warm; entering kidney and spleen meridians; the functions and indications are as follows: warming kidney and supporting yang, receiving qi and relieving asthma, warming spleen and relieving diarrhea; dispel wind and remove spots for external use. Can be used for treating kidney yang deficiency, sexual impotence, spermatorrhea, enuresis, frequent micturition, lumbago, knee pain, asthma due to kidney deficiency, and morning diarrhea; it is used externally to treat vitiligo and alopecia areata.

(16) Herba epimedii property, flavor and meridian tropism: pungent, sweet and warm; entering liver and kidney meridians; the efficacy and the main treatment are as follows: invigorating kidney, supporting yang, expelling pathogenic wind, removing dampness, and lowering blood pressure. In recent years, it is commonly used for treating hypertension of neurasthenia, menopause and yin-yang deficiency type.

(17) Cistanche property, flavor and channel tropism: warm in nature, sweet in taste and salty in taste; entering kidney and large intestine meridians; the efficacy is as follows: tonify kidney yang, replenish essence and blood, moisten intestines to relieve constipation; the main treatment is as follows: can be used for treating sexual impotence, spermatorrhea, lumbago, knee pain, asthenia, constipation due to intestinal dryness.

(18) The nature, flavor and meridian tropism of morinda officinalis: pungent and sweet with mild temperature. It enters kidney meridian.

The efficacy of morinda officinalis: tonify kidney, strengthen yang, dispel wind and remove dampness.

The main indications of morinda officinalis are as follows: can be used for treating sexual impotence, frequent micturition, infertility due to cold womb, and arthralgia due to wind-dampness.

The function brief introduction of each raw material medicine of the yin-yang medicine prescription of the Chinese medicinal preparation for treating hepatitis by dividing yin and yang into medicine and taking time by time is as follows:

(1) fructus Broussonetiae

Nature, flavor and meridian tropism: cold in nature and sweet in taste. It enters liver and kidney meridians.

The efficacy and the effect are as follows: tonifying kidney, removing liver heat, improving eyesight, and promoting urination; it is indicated for soreness and weakness of waist and knees, bone steaming due to asthenia, dizziness, blurred vision, nebula, edema and distention.

(2) Dried rehmannia root

Nature, flavor and meridian tropism: cold in nature and sweet in taste. They enter heart, liver and kidney meridians.

The efficacy and the effect are as follows: dried rehmannia root: clearing heat and cooling blood, nourishing yin and promoting fluid production; it is commonly indicated for deep-red tongue with polydipsia, yin deficiency with internal heat, bone steaming with internal heat, internal heat with diabetes, hematemesis, epistaxis, macula and eruption. Fresh rehmannia root: can be used for treating yin impairment due to febrile disease, crimson tongue with dipsosis, toxic heat, macula, hematemesis, epistaxis, and sore throat.

(3) Salted semen cuscutae

Nature, flavor and meridian tropism: mild in nature, pungent and sweet in flavor. It enters liver, kidney and spleen meridians.

The efficacy and the effect are as follows: tonifying kidney, nourishing essence, nourishing liver and improving eyesight; can be used for treating lumbago due to kidney deficiency, sexual impotence, premature ejaculation, turbid urine, leukorrhagia, and frequent micturition; threatened abortion; liver and kidney deficiency, blurred vision, and visual deterioration. In addition, it can be used for treating spleen deficiency, anorexia, and constipation.

(4) Chinese wolfberry

Nature, flavor and meridian tropism: mild in nature and sweet in taste. It enters liver and kidney meridians.

The efficacy and the effect are as follows: nourishing liver and kidney, replenishing vital essence and improving eyesight; it is indicated for consumptive disease, essence deficiency, soreness and pain of waist and knees, vertigo, tinnitus, internal heat, diabetes, blood deficiency, sallow complexion and blurred vision.

(5) Cortex Eucommiae

Nature, flavor and meridian tropism: slightly warm in nature and slightly bitter in taste; it enters liver and kidney meridians.

The efficacy and the effect are as follows: nourishing liver and kidney, strengthening tendons and bones, preventing miscarriage, and lowering blood pressure; it is indicated for lumbago due to kidney deficiency, weakness of tendons and bones, bleeding during pregnancy, fetal irritability, and hypertension.

(6) Rhizome of Siberian solomonseal

Nature, flavor and meridian tropism: mild in nature and sweet in taste; it enters lung, spleen and kidney meridians.

The efficacy and the effect are as follows: invigorating qi, nourishing yin, invigorating spleen, moistening lung, and invigorating kidney; it is used to treat weakness of spleen and stomach, tiredness, asthenia, xerostomia, dry cough due to lung deficiency, insufficiency of essence and blood, and diabetes due to internal heat.

(7) Radix polygonati officinalis

Nature, flavor and meridian tropism: slightly cold in nature and sweet in taste. It enters lung and stomach meridians.

The efficacy and the effect are as follows: nourishing yin, moistening dryness, promoting fluid production, and quenching thirst; it is indicated for yin deficiency of lung and stomach, cough due to dryness-heat, dry throat, thirst, and diabetes due to internal heat.

(8) Pulp of dogwood fruit

Nature, flavor and meridian tropism: slightly warm in nature, sour and astringent in taste. It enters liver and kidney meridians.

The efficacy and the effect are as follows: tonifying liver and kidney, inducing astringency and relieving depletion; can be used for treating vertigo, tinnitus, soreness of waist and knees, sexual impotence, spermatorrhea, enuresis, frequent micturition, metrorrhagia, leukorrhagia, sweating, internal heat, and diabetes.

(9) Schisandra chinensis

Nature, flavor and meridian tropism: sour taste, warm nature; it enters lung, kidney and heart meridians; the efficacy is as follows: astringe lung and kidney, promote the production of body fluid and arrest sweating, check diarrhea with astringents, and calm heart and tranquilize mind; the main treatment is as follows: can be used for treating chronic cough, asthma, thirst due to body fluid consumption, spontaneous perspiration, night sweat, spermatorrhea due to kidney deficiency, diarrhea due to deficiency of spleen and kidney, palpitation, and insomnia.

(10) Root of red-rooted salvia

Nature, flavor and meridian tropism: bitter taste and slight cold, heart, pericardium and liver meridian entered, and the efficacy: promoting blood circulation, removing blood stasis, cooling blood, eliminating carbuncle, nourishing blood and tranquillizing mind, and mainly treating: can be used for treating menoxenia, heart and abdomen pain, abdominal mass, rheumatism, heat arthralgia, pyocutaneous disease, swelling and pain, dysphoria, insomnia, palpitation, and insomnia.

(11) Bear gall powder

Nature, flavor and meridian tropism: bitter and cold. It enters liver, gallbladder and heart meridians.

The efficacy and the effect are as follows: clear heat and remove toxicity, extinguish wind and stop convulsion, clear liver and improve vision.

(12) Fire carbon nut

Nature, flavor and meridian tropism: slightly cold in nature, slightly sour and astringent in taste. It enters liver and spleen meridians.

The efficacy and the effect are as follows: clearing heat, promoting diuresis, cooling blood, removing toxic substances, improving eyesight, and removing nebula; it is indicated for summer-damp diarrhea, red and white dysentery, and chronic dysentery, and can also be decocted to make retention enema; pounding fresh product to affected part, and decocting for oral administration, for treating summer fever, anorexia, abdominal distention, damp-heat jaundice, cough due to lung heat, sore throat, diphtheria, acute mastitis, and furuncle; it is decocted in water for external washing for dermatitis, eczema and impetigo; the eye drop can be used for treating non-central corneal leukoma and external eye inflammation.

(13) Herba Paederiae

Nature, flavor and meridian tropism: mild in nature, sweet and bitter in taste. It enters spleen, stomach, liver and lung meridians.

The efficacy and the effect are as follows: dispelling pathogenic wind, promoting blood circulation, relieving pain, removing toxic substance, resolving food stagnation, eliminating dampness, and relieving swelling; it can be used for treating rheumatalgia, diarrhea, dysentery, abdominal pain, qi deficiency, edema, dizziness, anorexia, hepatosplenomegaly, lymphoid tuberculosis, acute appendicitis, undefined lump, and traumatic injury.

(14) Gynostemma pentaphylla

Nature, flavor and meridian tropism: cold in nature and bitter in taste. It enters lung, spleen and kidney meridians.

The efficacy and the effect are as follows: clearing away heat and toxic material, relieving cough and eliminating phlegm, and has the similar strengthening and tonifying effects of ginseng.

It can be used for treating chronic tracheitis, bronchial asthma, hyperlipidemia, arteriosclerosis, hepatitis, tumor, ulcer, insomnia, headache, and canities.

(15) Root of yellow wine

Nature, flavor and meridian tropism: slightly bitter and cool; it enters liver, spleen and stomach meridians.

The efficacy is as follows: cooling blood to stop bleeding, promoting diuresis to remove jaundice, removing blood stasis and strengthening tendons;

the medicinal material is commonly used for treating gingival bleeding, anemia, hepatitis, rheumatoid arthritis, traumatic injury and urinary tract infection.

(16) Piercing stone

Nature, flavor and meridian tropism: cool in nature, light in flavor and slightly bitter. It enters heart and liver meridians.

The efficacy and the effect are as follows: dispelling pathogenic wind, dredging collaterals, clearing heat, eliminating dampness, removing toxic substance and relieving swelling; can be used for treating rheumatic arthralgia, traumatic injury, jaundice, parotitis, and pulmonary tuberculosis. Stomach and duodenal ulcer, stranguria with turbid pathogen, tympanites, amenorrhea, internal injury, hemoptysis, furuncle, carbuncle and swelling.

(17) Herba Artemisiae Scopariae

Nature, flavor and meridian tropism: slightly cold in nature, bitter and pungent in flavor. It enters spleen, stomach and bladder meridians.

The efficacy and the effect are as follows: clearing away damp-heat and eliminating jaundice.

It can be used for treating icterohepatitis, oliguria, eczema, pruritus, and infectious icterohepatitis.

(18) Endothelium corneum Gigeriae Galli

Nature, flavor and meridian tropism: sweet and mild; entering spleen, stomach, small intestine and bladder meridians; the efficacy is as follows: invigorating stomach, promoting digestion, arresting spontaneous emission, and relieving enuresis; the main treatment is as follows: can be used for treating dyspepsia, infantile malnutrition, enuresis, nocturnal emission, and stranguria with stone.

(19) Rhizoma alismatis

Nature, flavor and meridian tropism: sweet, bland, cold; entering kidney and bladder meridians; the efficacy is as follows: promoting diuresis, eliminating dampness, and clearing away heat; the main treatment is as follows: can be used for treating dysuria, edema, diarrhea, stranguria with turbid urine, and leukorrhagia.

(20) Poria cocos (Schw.) wolf

Nature, flavor and meridian tropism: sweet, bland and mild; the heart, spleen and kidney meridians are entered; the efficacy is as follows: promoting diuresis, eliminating dampness, invigorating spleen, and tranquilizing; the main treatment is as follows: can be used for treating edema, diarrhea, dysuria, phlegm retention, palpitation, and insomnia.

(21) Radix Curcumae

Nature, flavor and meridian tropism: cold in nature, pungent and bitter in flavor, entering liver, heart and lung meridians, and has the functions of promoting blood circulation to arrest pain, promoting qi circulation to eliminate scabies, clearing away heart-fire and relieving depression, and benefiting gallbladder to cure jaundice. The clinical application is to treat amenorrhea, dysmenorrhea, coma due to febrile disease, epilepsy, mania, jaundice, dark urine, distending pain in chest and abdomen, and pricking pain.

(22) Malt

Nature, flavor and meridian tropism: mild in nature and sweet in taste. It enters spleen and stomach meridians.

The efficacy and the effect are as follows: promoting qi circulation, resolving food stagnation, invigorating spleen, promoting appetite, and relieving lactation and flatulence;

can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, and female hypogalactia. The raw malt has the effects of invigorating spleen, regulating stomach and promoting lactation, and can be used for treating spleen deficiency, anorexia and milk stagnation; parched fructus Hordei Germinatus has effects of activating qi-flowing, resolving food stagnation, and promoting lactation, and can be used for treating indigestion and female lactation interruption; charred malt can promote digestion and resolve stagnation, and is indicated for indigestion and abdominal distention and pain. Unprocessed for invigorating stomach, promoting digestion, soothing liver and harmonizing stomach; unprocessed or stir-baked for delactation; stir-baked for checking diarrhea.

(23) Tortoise plastron

Nature, flavor and meridian tropism: slightly cold in nature, salty and sweet in flavor. It enters liver meridian, kidney meridian and heart meridian.

The efficacy and the effect are as follows: nourishing yin, suppressing hyperactive yang, invigorating kidney, strengthening bone, nourishing blood, and tonifying heart;

can be used for treating hectic fever due to yin deficiency, night sweat due to bone steaming, dizziness, internal movement of deficient wind, flaccidity of tendons and bones, heart deficiency, and amnesia.

(24) Radix bupleuri

Nature, flavor and meridian tropism: pungent, bitter and slightly cold, entering liver, gallbladder and lung meridians, has the functions and main indications of dispelling and abating heat, soothing liver and relieving depression, and lifting yin qi, and is used for treating cold and fever, alternating cold and heat, distending pain in chest and hypochondrium, irregular menstruation, uterine prolapse and rectocele.

Specific tests and comparisons are made below by way of comparative examples:

comparative example 1, the high dose yin-yang combination preparation for treating chronic hepatitis was taken 3 times a day before meals in the morning, at noon and evening.

15 g of prepared monkshood, 30 g of astragalus, 15 g of bighead atractylodes rhizome, 15 g of cassia twig, 7.5 g of cinnamon, 7.5 g of cornu cervi degelatinatum, 7.5 g of pseudo-ginseng, 7.5 g of red ginseng, 15 g of angelica, 7.5 g of ligusticum wallichii, 15 g of honey-fried licorice root, 7.5 g of ephedra, 7.5 g of fructus amomi, 15 g of semen allii tuberosi, 15 g of fructus psoraleae, 15 g of herba epimedii, 15 g of cistanche and 15 g of morinda officinalis; 6 g of fructus broussonetiae, 15 g of radix rehmanniae, 15 g of common dodder seed, 15 g of medlar, 15 g of eucommia bark, 15 g of rhizoma polygonati, 15 g of polygonatum, 15 g of cornus officinalis, 10 g of Chinese magnoliavine fruit, 15 g of salvia miltiorrhiza, 0.5 g of bear gall powder, 7.5 g of herb of common knotweed, 7.5 g of paederia scandens, 7.5 g of gynostemma pentaphylla, 15 g of rhizoma coptidis, 15 g of cudrania root, 30 g of oriental wormwood, 7.5 g of chicken's gizzard-membrane, 15 g of rhizoma alismatis, 15 g of poria cocos, 10 g of radix curcumae, 30 g of malt, 30 g of tortoise plastron and 15 g of radix bupleuri.

Comparative example 2, the yang prescription of the high-dose Chinese medicinal preparation was administered in divided portions of yin and yang for treating chronic hepatitis, 3 times a day before meals in the morning, at noon and at night.

Wherein, 30 g of prepared aconite, 60 g of astragalus root, 30 g of largehead atractylodes rhizome, 30 g of cassia twig, 15 g of cinnamon, 15 g of deglued antler powder, 15 g of notoginseng, 15 g of red ginseng, 30 g of angelica, 15 g of szechuan lovage rhizome, 30 g of honey-fried licorice root, 15 g of ephedra, 15 g of villous amomum fruit, 30 g of tuber onion seed, 30 g of salt psoralea fruit, 30 g of epimedium herb, 30 g of desertliving cistanche and 30 g of morinda root.

Comparative example 3, the yin prescription of the high-dose Chinese medicinal preparation is taken only by taking yin and yang divided medicines for treating chronic hepatitis at different times, and the medicine is taken 3 times in the morning, at noon and at night each day.

Wherein, the traditional Chinese medicine comprises 12 g of papermulberry fruit, 30 g of dried rehmannia root, 30 g of common dodder seed, 30 g of medlar, 30 g of eucommia bark, 30 g of sealwort, 30 g of polygonatum, 30 g of cornus, 15 g of Chinese magnoliavine fruit, 30 g of salvia miltiorrhiza, 1.0 g of bear gall powder, 15 g of herb of common knotweed, 15 g of paederia scandens, 15 g of fiveleaf gynostemma herb, 30 g of rhizoma coptidis, 30 g of cudrania root, 60 g of oriental wormwood, 15 g of chicken's gizzard-membrane, 30 g of oriental waterplantain rhizome, 30 g of tuckahoe, 15 g of radix curcumae, 60 g of malt, 60 g of tortoise plastron and 30 g of radix bupleuri.

In the comparative examples, the in vivo animal model method was used to evaluate the therapeutic effects of the various agents, and a concanavalin-induced immune liver injury model method was used for specific comparison and experiments.

Rats 160 were randomly assigned to 8 groups: group A: blank group, group B: model group, group C: high concentration yin-yang divided medicinal preparation group, group D: the intermediate concentration yin-yang divided medicine preparation group comprises: low concentration yin-yang divided medicinal preparation group, group F: high concentration yin-yang combined preparation group, group G: high concentration yang drug formulation group, group H: high concentration yin medicinal preparation. The administration was performed by gavage 1 time a day, and equal volume of 1% sodium carboxymethylcellulose was administered to both blank group and model group for 2 weeks. After fasting for 2 hours on day 14, canavalin A25mg/kg was injected into the tail vein, and normal saline was injected into the blank group. After 8 hours, anesthesia was performed with 10% chloral hydrate, blood was taken from the eyeball, and serum was separated to determine ALT value. Washing another liver tissue with normal saline, sucking, weighing, cutting into pieces, making into liver homogenate with mass fraction of 10%, centrifuging, collecting supernatant, and measuring values of SOD, OCT, TNF-alpha and IL-1.

The experimental results are as follows:

the serum ALT value and the OCT, TNF-alpha and IL-1 values in liver tissues of the model group rats are obviously increased, and the SOD value is obviously reduced. Compared with the model group, the samples have the effects of inhibiting the elevation of ALT level in serum of a rat with the immunological liver injury to different degrees, reducing the levels of medium OCT, TNF-alpha and IL-1 in liver tissues and increasing SOD value, and the results are shown in the following table, wherein the effects of different traditional Chinese medicine preparations on the ALT, OCT, TNF-alpha, IL-1 and SOD value of the immunological liver injury are shown in the following table (x +/-s, n is 20).

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The results show that the high-concentration yin-yang medicine separating preparation, the medium-concentration yin-yang medicine combining preparation, the low-concentration yin-yang medicine combining preparation and the high-concentration yin-yang medicine combining preparation have obvious treatment effects on chronic hepatitis. The therapeutic effect of the high, medium and low concentration yin-yang medicine separating preparation group is superior to that of the high concentration yin-yang medicine combining preparation group, which shows that the yin-yang medicine separating preparation has better therapeutic effect.

The yang medicine preparation and the yin medicine preparation have certain treatment effect when being taken independently, and compared with a model group, the yin medicine preparation group is superior to the yang medicine preparation group, which shows that the effect of treating chronic hepatitis by using a pure positive traditional Chinese medicine preparation is not good.

The clinical pharmacodynamics research of the pharmaceutical composition of the invention is as follows: the high-concentration yin-yang medicine dividing preparation and the high-concentration yin-yang medicine combining formula granular preparation of the control sample are used for 132 patients with chronic hepatitis, and are randomly prescribed to treat 61 patients, the high-concentration yin-yang medicine dividing preparation of the patients is taken twice every day, the dosage of the yang medicine is one time in the morning and one half of the side-by-side dosage of the yang medicine, and the dosage of the half of the side-by-side dosage of the yin medicine is taken once before dinner. The high-concentration yin-yang combined preparation is taken once every morning and before dinner, and a dose is once a day.

After taking the medicine for 3 months, the results of liver function index, physical strength, liver somatosensory, jaundice, anorexia and the like are reviewed, and the results are statistically analyzed. The effective rates of the sample of the invention on the symptoms of liver function recurrence, hypodynamia, liver discomfort, jaundice and anorexia are respectively 95.8%, 76.3%, 89.6%, 93.3% and 94.7%. The effective rates of the control samples on the liver function index recurrence, hypodynamia, liver discomfort, jaundice and anorexia are 72.0%, 69.3%, 62.6%, 81.4% and 73.9%, respectively. The results of the two groups are obviously different and have statistical significance.

This shows that the yin-yang medicine dividing preparation for treating chronic hepatitis is superior to the yin-yang medicine combining preparation for treating chronic hepatitis. Moreover, in the treatment process, the sleep improvement rate of the patient taking the yin-yang medicine dividing preparation reaches 96 percent, while the sleep improvement rate of the patient taking the yin-yang medicine combining preparation is only about 76 percent, which is consistent with the treatment effect. The yin-yang combined preparation for treating chronic hepatitis is easy to cause poor sleep, which is an important reason for poor effect of the yin-yang combined preparation for treating chronic hepatitis.

Therefore, the invention has the following advantages:

1. the yang medicine prescription raw material formula for yin-yang divided medicine time-sharing administration for treating chronic hepatitis has certain efficacy of promoting liver and gallbladder yang qi rising and promoting liver and gallbladder toxin expelling due to synergistic effect of the raw materials, and specifically comprises the following raw materials: the yang medicine prescription for treating chronic hepatitis comprises radix Aconiti lateralis Preparata, radix astragali, Atractylodis rhizoma, ramulus Cinnamomi, cortex Cinnamomi, cornu Cervi Degelatinatum, Notoginseng radix, Ginseng radix, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, radix Glycyrrhizae Preparata, herba Ephedrae, fructus Amomi, semen Allii Tuberosi, Sal fructus Psoraleae, herba Epimedii, Cistanchis herba, and radix Morindae officinalis. According to the theory of traditional Chinese medicine for treating diseases by dividing meridians, the prepared monkshood mainly tonifies heart yang, the red ginseng mainly tonifies spleen yang, the astragalus root mainly tonifies stomach yang, the ephedra mainly tonifies lung yang, the angelica mainly tonifies liver yang, and the salt fructus psoraleae mainly tonifies kidney yang, and the six medicines are monarch medicines; cassia twig, ramulus Cinnamomi warms channel to dispel cold, and Zingiberis rhizoma warms middle energizer, and the two are ministerial drugs for preparing radix Aconiti lateralis; the bighead atractylodes rhizome is used as a ministerial drug of the red ginseng, and has the effects of strengthening spleen, tonifying qi, eliminating dampness, promoting diuresis and arresting sweating; fructus amomi is a ministerial drug of radix astragali and is used for resolving dampness, stimulating appetite, warming spleen and stopping diarrhea; the hemlock parsley has the functions of promoting qi and blood circulation, dispelling wind and relieving pain, and the pseudo-ginseng has the functions of dissipating blood stasis and stopping bleeding, and reducing swelling and relieving pain, and the two are ministerial medicaments of the angelica; herba Epimedii has effects in invigorating kidney yang, strengthening tendons and bones, dispelling pathogenic wind, removing dampness, and herba cistanches has effects in invigorating kidney yang, replenishing essence and blood, and loosening bowel to relieve constipation; the six medicines are all liver and kidney tonifying medicines and are all ministerial medicines of the fructus psoraleae. Prepared licorice root, radix Glycyrrhizae Praeparata, as a guiding drug, assists in the preparation of radix Aconiti lateralis, and regulates the effects of the other drugs in the recipe. The disease root of chronic hepatitis is yang deficiency in the interior and yin accumulation in the interior; the comprehensive efficacy of the yang medicine prescription of the Chinese medicine preparation which is taken by dividing yin into yang and time is to tonify the yang of internal organs of human body, warm heart yang, strengthen spleen and stomach, benefit lung qi, raise the yang qi of liver and gall, promote the toxin expelling of liver and gall, thus eliminating inflammation substances caused in vivo. Meanwhile, the rising of kidney yang can promote hematopoiesis, generate water and wood, and promote hematopoiesis and liver nourishing, thereby fundamentally promoting the rising of liver yang and providing a foundation.

2. The yang-tonifying medicine for treating chronic hepatitis is taken at yang time, has half-effect, and does not worry about that a large amount of yang-tonifying medicines damage liver yin, kidney yin and lung yin. In the morning and at noon, the influence or damage of the yang-tonifying herbs on the liver-gallbladder yin channel, the kidney-yin channel and the lung-yin channel is reduced to the minimum because the liver-gallbladder channel and the kidney-yin channel move in the low tide period. Before breakfast and before lunch, the activity of spleen and stomach, heart channel and liver and gall yang channels is in climax period, so that the yang-warming effect of the yang-warming medicine on heart yang, spleen and stomach and liver and gall yang channels is maximized, liver blood output is greatly promoted, liver and gall secretion and bile discharge are promoted, and liver and gall detoxification is greatly promoted. The yang-invigorating medicine is taken in the morning and at noon, is in the atmospheric environment and the qi-blood environment of a human body at the yang-qi-ascending stage, so when the yang-invigorating medicine is taken at the time, triple resonance and common frequency effects can be generated in the medicine, the human body and the environment, and the medicine taking effect with half the effort can be generated. Yang-tonifying herbs have the effects of promoting blood circulation to remove blood stasis, warming yang qi of internal organs, dredging channels and collaterals, enabling heart fire and liver and gallbladder fire to enter spleen and stomach smoothly, and preventing pathogenic heat from entering liver and gallbladder or kidney, so that the effect of treating the chronic hepatitis is achieved;

3. the yin-yang medicine for treating chronic hepatitis has the strong effects of nourishing yin, promoting blood production, nourishing liver and promoting liver and gall detoxification, and specifically comprises the following raw materials in a formula of the yin-yang medicine taken by dividing the yin into medicines in different time: the yin prescription for treating chronic hepatitis comprises fructus Broussonetiae, radix rehmanniae, semen Cuscutae, fructus Lycii, Eucommiae cortex, rhizoma Polygonati Odorati, Corni fructus, fructus Schisandrae chinensis, Saviae Miltiorrhizae radix, fel Ursi powder, herb Polygoni chinensis, herba Paederiae, herba Gynostemmatis, radix astragali, radix Cudraniae, herba Artemisiae Scopariae, endothelium corneum Gigeriae Galli, Alismatis rhizoma, Poria, radix Curcumae, fructus Hordei Germinatus, carapax et Plastrum Testudinis, and bupleuri radix; the bear gall powder starts to activate the channels and collaterals of the whole body, softens bile ducts, promotes the liver and gall to expel toxin, is a monarch drug of yin drugs, the endothelium corneum gigeriae galli and the malt invigorate the stomach and promote digestion, eliminates stasis of the liver and the gall, the rhizoma alismatis purges the toxin of the liver and the gall, the poria cocos dispels the dampness of the spleen and the stomach, the salvia miltiorrhiza purges heart fire, nourishes heart yin, and the four drugs are ministerial drugs for clearing heat and purging liver fire; the five medicines, namely the five medicines, which clear heat and detoxify and are also ministerial medicines, have the effects of clearing heat and detoxifying, cooling blood and detoxifying, the paederia scandens has the effects of dispelling wind and activating blood, relieving pain and detoxifying, promoting digestion and removing food stagnation, and eliminating dampness and swelling, the gynostemma pentaphylla has the effects of clearing heat and detoxifying, relieving cough and eliminating phlegm, the oriental wormwood has the effects of clearing damp and heat, and eliminating jaundice, the radix curcumae has the effects of activating blood and detoxifying, promoting qi circulation and removing scabies, clearing heart and resolving depression, and benefiting gallbladder and eliminating jaundice; the Chinese magnoliavine fruit has the effects of astringing lung and kidney, promoting fluid production and arresting sweating, tonifying liver and kidney, the eucommia bark has the effects of tonifying liver and kidney, strengthening tendons and bones, the dogwood fruit has the effects of tonifying liver and kidney, inducing astringency and relieving depletion, and the eucommia bark, the Chinese magnoliavine fruit and the dogwood fruit have the effects of directly nourishing the liver and are monarch drugs for nourishing the liver; rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, rhizoma Polygonati Odorati has effects of nourishing yin, moistening dryness, promoting fluid production, quenching thirst, nourishing lung, and replenishing water; the papermulberry fruit has the effects of tonifying kidney, clearing liver, improving eyesight and promoting urination, the rehmannia root has the effects of clearing heat, cooling blood, nourishing yin and promoting fluid production, the common dodder seed, the Chinese wolfberry fruit, the liver and the kidney and the essence and the eyesight are nourished, and the four medicines have the effects of nourishing yin and the kidney, and are used for promoting the growth of aquatic wood and indirectly nourishing the liver; the six medicines combine to nourish the liver and the gallbladder and are ministerial medicines. The radix astragali is used for cooling blood and stopping bleeding, promoting diuresis and removing jaundice, dissipating blood stasis and strengthening tendons, breaking stone and dispelling wind and dredging collaterals, clearing heat and removing dampness, detoxifying and reducing swelling, nourishing yin and suppressing yang of tortoise plastron, tonifying kidney and strengthening bone, nourishing blood and tonifying heart, dispersing and removing heat of radix bupleuri, soothing liver and relieving depression, and lifting yin qi. The comprehensive effects of yin and yang divided medicine and time-sharing administration of yin and yang of the traditional Chinese medicine preparation are clearing heat, expelling toxin, softening hardness, dissipating stagnation, soothing liver, relieving depression, nourishing liver and kidney, nourishing yin, promoting the production of body fluid, nourishing yin, promoting the production of blood, activating meridians of the whole body, softening bile ducts, promoting the expulsion of liver and gallbladder, being the monarch medicine of yin medicines, strengthening stomach, promoting digestion, eliminating stagnation of liver and gallbladder, purging the toxicity of liver and gallbladder by rhizoma alismatis, eliminating dampness of spleen and stomach by poria cocos, purging heart fire by salvia miltiorrhiza, and nourishing heart yin, and the four medicines are ministerial medicines for clearing heat and purging liver fire; the five medicines, namely the five medicines, which clear heat and detoxify and are also ministerial medicines, have the effects of clearing heat and detoxifying, cooling blood and detoxifying, the paederia scandens has the effects of dispelling wind and activating blood, relieving pain and detoxifying, promoting digestion and removing food stagnation, and eliminating dampness and swelling, the gynostemma pentaphylla has the effects of clearing heat and detoxifying, relieving cough and eliminating phlegm, the oriental wormwood has the effects of clearing damp and heat, and eliminating jaundice, the radix curcumae has the effects of activating blood and detoxifying, promoting qi circulation and removing scabies, clearing heart and resolving depression, and benefiting gallbladder and eliminating jaundice; the Chinese magnoliavine fruit has the effects of astringing lung and kidney, promoting fluid production and arresting sweating, tonifying liver and kidney, the eucommia bark has the effects of tonifying liver and kidney, strengthening tendons and bones, the dogwood fruit has the effects of tonifying liver and kidney, inducing astringency and relieving depletion, and the eucommia bark, the Chinese magnoliavine fruit and the dogwood fruit have the effects of directly nourishing the liver and are monarch drugs for nourishing the liver; rhizoma Polygonati has effects of invigorating qi, nourishing yin, invigorating spleen, moistening lung, invigorating kidney, rhizoma Polygonati Odorati has effects of nourishing yin, moistening dryness, promoting fluid production, quenching thirst, nourishing lung, and replenishing water; the papermulberry fruit has the effects of tonifying kidney, clearing liver, improving eyesight and promoting urination, the rehmannia root has the effects of clearing heat, cooling blood, nourishing yin and promoting fluid production, the common dodder seed, the Chinese wolfberry fruit, the liver and the kidney and the essence and the eyesight are nourished, and the four medicines have the effects of nourishing yin and the kidney, and are used for promoting the growth of aquatic wood and indirectly nourishing the liver; the six medicines combine to nourish the liver and the gallbladder and are ministerial medicines. The radix astragali is used for cooling blood and stopping bleeding, promoting diuresis and removing jaundice, dissipating blood stasis and strengthening tendons, breaking stone and dispelling wind and dredging collaterals, clearing heat and removing dampness, detoxifying and reducing swelling, nourishing yin and suppressing yang of tortoise plastron, tonifying kidney and strengthening bone, nourishing blood and tonifying heart, dispersing and removing heat of radix bupleuri, soothing liver and relieving depression, and lifting yin qi. The comprehensive effects of yin and yang divided medicine taking of the yin medicine of the traditional Chinese medicine preparation for treating chronic hepatitis are clearing heat and expelling toxin, softening hardness and dissipating stagnation, soothing liver and relieving depression, nourishing liver and kidney, nourishing yin and promoting the production of body fluid, and nourishing yin and generating blood.

4. The yin-nourishing medicine for treating chronic hepatitis is taken in the time of yin, the medicine is half-effective, and a large amount of yin-nourishing medicines do not need to hurt heart yang and spleen yang. In the morning and at noon, the activity of spleen yang meridians, heart yang meridians and liver yang meridians is in climax, so when yin is used, heart yang, spleen yang and liver yang are inevitably damaged. Before dinner and before sleep, the activity of spleen yang, heart yang and liver yang channels is in low tide period, so that the damage to heart yang channels, spleen yang channels and liver yang channels is reduced to minimum by using yin-nourishing medicines. Since the yin-nourishing medicine is taken before dinner or one hour before sleep at night, the atmospheric environment and the qi and blood environment of the human body are in the stages of yin qi rising and yang qi falling, when the yin-rising yin-nourishing medicine is taken at the moment, triple resonance and common frequency effects can be generated on the medicine, the human body and the environment, and the administration effect which is half-time of that of the medicine can be generated. Yin-nourishing and promoting the production of body fluid, subsiding yang qi of internal organs, raising yin water, dredging channels and collaterals, excreting toxic materials from liver and gallbladder, allowing liver toxin to enter gallbladder and then enter gastrointestinal tract via gallbladder homeopathic conditions, and preventing pathogenic heat or toxic materials from entering liver, gallbladder or kidney, thereby achieving the effects of removing toxic substances and treating symptoms of chronic hepatitis. The yin herbs comprise a large amount of blood-producing and body fluid-generating herbs for nourishing liver and kidney, and the herbs can nourish liver and kidney and repair liver cells and tissues, thereby playing the role of preparing the root.

5. The yin medicine taken by dividing the yin into the yang medicine for treating chronic hepatitis in a time-sharing way and the yang medicine taken by dividing the yin into the yang medicine for treating chronic hepatitis in a time-sharing way are taken separately, so that the yang medicine or the yin medicine can exert the maximum effect, and the phytotoxicity is avoided or reduced. Chronic hepatitis, which indicates that the pathogenic factors of the patient have invaded from the taiyang channel, yangming channel, to shaoyang channel, even jueyin channel. At this time, qi and blood in the body are abnormally circulated in the heart, spleen and stomach, liver, gallbladder, lung and kidney, and the five zang organs are transformed from generation to restriction. Traditional Chinese medicine often utilizes yin and yang combination medicine for treatment, and the condition of taking care of yin and yang is often caused when the medicine is taken for no matter in time. If the yin-yang combination is warm, it is good for heart, spleen and stomach when taken in the morning and at noon, and is not good for liver, gallbladder, kidney and lung when taken at night. Vice versa, if yin-yang combination is cold, it is not good for heart, spleen and stomach, and it is good for liver, gallbladder, kidney and lung. The medicine is divided into yin and yang, yang medicine is taken in yang time, and yin medicine is taken in yin time, so that the medicines and time generate common frequency or resonance effect, the medicine effect is enhanced, the condition that the medicine property is wrong with time is thoroughly avoided or reduced, and the condition that the medicine property is wrong with the environment is thoroughly avoided or reduced.

The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, which are made by the present specification, or directly or indirectly applied to other related technical fields, are included in the scope of the present invention.

Claims

1. A traditional Chinese medicine preparation for chronic hepatitis is characterized by comprising a first prescription consisting of medicines with the property of pungent, hot, pungent, warm and yang-strengthening and a second prescription consisting of medicines with the property of bitter and cold, cool and slippery diarrhea or acidic convergence, wherein the first prescription comprises the following active ingredients in percentage by mass:

2. The traditional Chinese medicine preparation for chronic hepatitis as claimed in claim 1, wherein the effective components of the first preparation comprise, by mass:

3. The traditional Chinese medicine preparation for chronic hepatitis as claimed in claim 1, wherein the effective components of the first preparation comprise, by mass:

4. The traditional Chinese medicine preparation for chronic hepatitis as claimed in claim 1, wherein the effective components of the first preparation comprise, by mass:

5. A method for preparing the traditional Chinese medicine preparation for chronic hepatitis, which is used for preparing the traditional Chinese medicine preparation for chronic hepatitis of any one of the claims 1 to 4, is characterized in that the method for preparing the traditional Chinese medicine preparation for chronic hepatitis comprises the following steps:

s4, filtering the second prescription extract, concentrating, adding dextrin, drying at high temperature, granulating and sieving to obtain the second prescription granular preparation.

6. The method for preparing a Chinese medicinal preparation for chronic hepatitis according to claim 5, wherein in steps S1 and S3, the heating temperature is set to 80-100 ℃; the heating time is set to be 1-6 hours.

7. The method for preparing a Chinese medicinal preparation for chronic hepatitis according to claim 5, wherein in steps S1 and S2, the method comprises the following steps:

8. The method for preparing a Chinese medicinal preparation for chronic hepatitis according to claim 5, wherein in steps S3 and S4, the method comprises the following steps:

adding 6 times of water according to the formula, decocting twice, each time for 1.5 hours, filtering the decoction, concentrating, adding dextrin when the filtrate is concentrated to a certain density, finally adding bear gall powder and amber powder, stirring, granulating, and drying to obtain yin medicine granules of the yin-yang divided medicine time-sharing administration preparation for treating chronic hepatitis;

9. A method for administering the Chinese medicinal preparation for chronic hepatitis according to any one of claims 1 to 4, comprising: the first formulation is administered twice daily and the second formulation is administered twice daily.

10. The method of claim 9, wherein the first dosage is administered for the first time in the following time ranges: the time range of the second administration of the first formulation is from 6 th to 9 th: time 11-13; the time range for the first administration of the second formula is as follows: the time range of the first administration of the second formula from 17 hours to 21 hours is as follows: the second formulation is administered at a time between 21 hours and 24 hours, separated from the time of the first administration by at least one hour.