CN110025704A - Chinese herbal formula and preparation method thereof for treating grice diarrhoea - Google Patents

Chinese herbal formula and preparation method thereof for treating grice diarrhoea Download PDF

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CN110025704A
CN110025704A CN201910449131.0A CN201910449131A CN110025704A CN 110025704 A CN110025704 A CN 110025704A CN 201910449131 A CN201910449131 A CN 201910449131A CN 110025704 A CN110025704 A CN 110025704A
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parts
powder
chinese medicine
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radix
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CN110025704B (en
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左瑞华
蒋平
孙桃桃
黄仁术
佘德勇
夏伦斌
刘莹莹
卢道强
查秀兰
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West Anhui University
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    • A61K33/00—Medicinal preparations containing inorganic active ingredients
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    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
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    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention discloses a kind of for treating the Chinese herbal formula of grice diarrhoea, according to parts by weight includes Radix Codonopsis 10-30 parts, 3-10 parts of Radix Astragali, 3-8 parts of radix bupleuri, 2-6 parts of Poria cocos, 1-3 parts of Herba Andrographitis, 1-5 parts of the coptis, 0.5-4.5 parts of Semen Arecae (parched), 0.5-2 parts of rheum officinale, 1-3 parts of rhizoma atractylodis macrocephalae, 1-4 parts of dried orange peel, 1-3 parts of gypsum, 1-4 parts of meadowrueleaf corydalis root, it is 10-40 parts of dandelion, 1-15 parts windproof, 1-6 parts of radix glycyrrhizae preparata；Chinese herbal formula of the invention, which has, is obviously improved grice diarrhoea symptom, improve the effect of pigling immunity etc., said preparation can substitute part chemicals, achieve the purpose that treat grice diarrhoea, simple process, it is low for equipment requirements, easily implement, it is convenient that obtained Chinese herbal formula is fed, nontoxic, harmless, noresidue, safety is good, is able to satisfy demand of the people to publicly harmless animal product.

Description

Chinese herbal formula and preparation method thereof for treating grice diarrhoea
Technical field
The present invention relates to a kind of Chinese herbal formulas and preparation method thereof for treating grice diarrhoea, belong to Chinese medicine skill Art field.
Background technique
Grice diarrhoea is a kind of typical multifactor property disease under intensive pig production working condition, is current most serious One of piglet diseases group, and cause the major reason of piglet death, according to investigations, piglet accounts for the dead sum of piglet because of diarrhea death 39.8%, grice diarrhoea pig breeding industry harm in rank first, seriously threaten the sound development of pig breeding industry, lead to the price of deed Rate is lower, piglet survival ratio decline, slow growth, growth and development are stagnated, or even dead, clinically mainly uses antibiosis at present Extract for treating grice diarrhoea, but effect be not it is too ideal, exist simultaneously medicament residue etc. harm.
Summary of the invention
The Chinese herbal formula and its preparation that the main purpose of the present invention is to provide a kind of for treating grice diarrhoea Method has and is obviously improved grice diarrhoea symptom, improves the effect of pigling immunity etc., can substitute part chemicals, reach Purpose to treatment grice diarrhoea can effectively solve the problems in background technique.
To achieve the above object, the technical scheme adopted by the invention is as follows:
A kind of include Radix Codonopsis 10-30 parts for treating the Chinese herbal formula of grice diarrhoea according to parts by weight, Radix Astragali 3-10 parts, 3-8 parts of radix bupleuri, 2-6 parts of Poria cocos, 1-3 parts of Herba Andrographitis, 1-5 parts of the coptis, 0.5-4.5 parts of Semen Arecae (parched), 0.5-2 parts of rheum officinale, It is 1-3 parts of rhizoma atractylodis macrocephalae, 1-4 parts of dried orange peel, 1-3 parts of gypsum, 1-4 parts of meadowrueleaf corydalis root, 10-40 parts of dandelion, 1-15 parts windproof, radix glycyrrhizae preparata 1- 6 parts.
It is walked the present invention also provides a kind of for treating the preparation method of the Chinese herbal formula of grice diarrhoea, including as follows It is rapid:
(1) by Radix Codonopsis, Radix Astragali, Poria cocos, Semen Arecae (parched), rhizoma atractylodis macrocephalae, dried orange peel, radix saposhnikoviae, radix glycyrrhizae preparata etc. according to above-mentioned parts by weight meter Mixing pulverizes and obtains Chinese medicine mixing Ultramicro-powder a；
(2) Herba Andrographitis, rheum officinale, the coptis, meadowrueleaf corydalis root etc. are mixed to pulverize according to above-mentioned parts by weight meter and is mixed for Chinese medicine Ultramicro-powder b；
(3) radix bupleuri, gypsum, dandelion are individually pulverized；
(4) after pulverizing, by Chinese medicine mixing Ultramicro-powder a, radix bupleuri Ultramicro-powder, dandelion Ultramicro-powder respectively in 10 times of water It impregnates 1 hour；
(5) radix bupleuri Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, Chinese medicine mixed super Micro mist a is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, and dandelion Ultramicro-powder is put into Chinese medicine extracting tank and is boiled It is kept for slight boiling condition 1 hour after boiling, gypsum Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 2 hours；
(6) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, close And filtrate three times；
(7) Chinese medicine mixing Ultramicro-powder b is put into Chinese medicine extracting tank, with 80% alcohol steep 1 hour of 20 times, extraction temperature Degree is 80 DEG C, tapping, filtering, and the dregs of a decoction continue to extract after adding 15 times of 80% ethyl alcohol measured again according to above-mentioned steps, so three times, is closed And filtrate three times；
(8) rotary evaporation recycles ethyl alcohol after extracting, and obtains medicinal extract, gained medicinal extract Chinese medicine mixing Ultramicro-powder a extracting solution Dissolution；
(9) all extracting solutions are mixed, it is 0.5g/mL that 50-60 DEG C, which is concentrated into crude drug concentration, and bottling sterilizes to get medium-height grass Medicine compound preparation.
Chinese herbal formula of the invention, which has, is obviously improved grice diarrhoea symptom, improves the work of pigling immunity etc. With said preparation can substitute part chemicals, achieve the purpose that treat grice diarrhoea, simple process is low for equipment requirements, easily Implement, it is convenient that obtained Chinese herbal formula is fed, and nontoxic, harmless, noresidue, safety is good, is able to satisfy people to nothing The demand of public hazards livestock products.
Specific embodiment
To be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention, below with reference to Specific embodiment, the present invention is further explained.
A kind of include Radix Codonopsis 10-30 parts for treating the Chinese herbal formula of grice diarrhoea according to parts by weight, Radix Astragali 3-10 parts, 3-8 parts of radix bupleuri, 2-6 parts of Poria cocos, 1-3 parts of Herba Andrographitis, 1-5 parts of the coptis, 0.5-4.5 parts of Semen Arecae (parched), 0.5-2 parts of rheum officinale, It is 1-3 parts of rhizoma atractylodis macrocephalae, 1-4 parts of dried orange peel, 1-3 parts of gypsum, 1-4 parts of meadowrueleaf corydalis root, 10-40 parts of dandelion, 1-15 parts windproof, radix glycyrrhizae preparata 1- 6 parts.
It is walked the present invention also provides a kind of for treating the preparation method of the Chinese herbal formula of grice diarrhoea, including as follows It is rapid:
(1) by Radix Codonopsis, Radix Astragali, Poria cocos, Semen Arecae (parched), rhizoma atractylodis macrocephalae, dried orange peel, radix saposhnikoviae, radix glycyrrhizae preparata etc. according to above-mentioned parts by weight meter Mixing pulverizes and obtains Chinese medicine mixing Ultramicro-powder a；
(2) Herba Andrographitis, rheum officinale, the coptis, meadowrueleaf corydalis root etc. are mixed to pulverize according to above-mentioned parts by weight meter and is mixed for Chinese medicine Ultramicro-powder b；
(3) radix bupleuri, gypsum, dandelion are individually pulverized；
(4) after pulverizing, by Chinese medicine mixing Ultramicro-powder a, radix bupleuri Ultramicro-powder, dandelion Ultramicro-powder respectively in 10 times of water It impregnates 1 hour；
(5) radix bupleuri Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, Chinese medicine mixed super Micro mist a is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, and dandelion Ultramicro-powder is put into Chinese medicine extracting tank and is boiled It is kept for slight boiling condition 1 hour after boiling, gypsum Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 2 hours；
(6) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, close And filtrate three times；
(7) Chinese medicine mixing Ultramicro-powder b is put into Chinese medicine extracting tank, with 80% alcohol steep 1 hour of 20 times, extraction temperature Degree is 80 DEG C, tapping, filtering, and the dregs of a decoction continue to extract after adding 15 times of 80% ethyl alcohol measured again according to above-mentioned steps, so three times, is closed And filtrate three times；
(8) rotary evaporation recycles ethyl alcohol after extracting, and obtains medicinal extract, gained medicinal extract Chinese medicine mixing Ultramicro-powder a extracting solution Dissolution；
(9) all extracting solutions are mixed, it is 0.5g/mL that 50-60 DEG C, which is concentrated into crude drug concentration, and bottling sterilizes to get medium-height grass Medicine compound preparation.
Embodiment 1
It is a kind of for treating the Chinese herbal formula of grice diarrhoea, in parts by weight, including following components: Radix Codonopsis 10 Part, it is 10 parts of Radix Astragali, 8 parts of radix bupleuri, 5 parts of Poria cocos, 3 parts of Herba Andrographitis, 2 parts of the coptis, 4 parts of Semen Arecae (parched), 1 part of rheum officinale, 2 parts of rhizoma atractylodis macrocephalae, old 3 parts of skin, 3 parts of gypsum, 2 parts of meadowrueleaf corydalis root, 15 parts of dandelion, 7 parts of radix saposhnikoviae, prepares compound according to above-mentioned preparation method by 5 parts of radix glycyrrhizae preparata Preparation.
Embodiment 2
It is a kind of for treating the Chinese herbal formula of grice diarrhoea, in parts by weight, including following components: Radix Codonopsis 15 Part, 5 parts of Radix Astragali, 5 parts of radix bupleuri, 6 parts of Poria cocos, 2 parts of Herba Andrographitis, 3 parts of the coptis, 3 parts of Semen Arecae (parched), 2 parts of rheum officinale, 3 parts of rhizoma atractylodis macrocephalae, dried orange peel 1 part, 2 parts of gypsum, 3 parts of meadowrueleaf corydalis root, 20 parts of dandelion, 10 parts of radix saposhnikoviae, prepares compound according to above-mentioned preparation method by 4 parts of radix glycyrrhizae preparata Preparation.
Embodiment 3
It is a kind of for treating the Chinese herbal formula of grice diarrhoea, in parts by weight, including following components: Radix Codonopsis 12 Part, 12 parts of Radix Astragali, 8 parts of radix bupleuri, 4 parts of Poria cocos, 1 part of Herba Andrographitis, 5 parts of the coptis, 4.5 parts of Semen Arecae (parched), 0.5 part of rheum officinale, rhizoma atractylodis macrocephalae 1.5 Part, 2 parts of dried orange peel, 1 part of gypsum, 4 parts of meadowrueleaf corydalis root, 10 parts of dandelion, 5 parts of radix saposhnikoviae, 3 parts of radix glycyrrhizae preparata, according to above-mentioned preparation method system Standby compound preparation.
Diarrhea piglet 40 of 40 ages in days are selected, 4 groups, respectively example 1 group, 2 groups of embodiment, embodiment are divided into 3 groups and control group, every group 10；3 groups of example 1 group, 2 groups of embodiment, embodiment diarrhea piglets, according to every pig 5g crude drug The Chinese herbal formula in embodiment 1, embodiment 2 and embodiment 3 is added in drinking-water respectively for dosage, drinking water administration, daily Morning is primary, once a day, continuous 7 days；Control group diarrhea piglet feeds florfenicol powder；After medication, weighing is non-anticoagulant Pipe acquires jugular vein blood, and centrifugation takes serum, detects liver function (AST, ALT) and kidney according to the requirement of full-automatic biochemical kit Function (CREA, BUN)；It is horizontal according to the detection method detection IgG of IgGELISA kit.
Before test, morbidity piglet is apathetic, hunchbacked, is reluctant to walk, and anorexia, frequency arranges the loose stool with mucus, perianal Faecal contamination, serious person show Sunken orbital socket, dehydration；After test, the spirit of weak piglet is significantly improved, and appetite enhancing is adopted Appetite dramatically increases, and row's loose stool situation is alleviated substantially；Control group diarrhea cure rate 6,4 significant alleviations；Example 1 group 9 are fullyed recover from an illness More, 1 is almost recovered；2 groups of 8 recoveries from illness of example, 2 significant alleviations；3 groups of 8 recoveries from illness of example, 1 is almost recovered, and 1 significant Alleviate；It can be seen that Chinese herbal formula of the invention has preferable clinical efficacy in terms for the treatment of grice diarrhoea.
Influence (g/L) of 1 Chinese herbal formula of table to diarrhea piglet Serological IgG level
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 1, when off-test, example 1 group, 2 groups of embodiment, 3 groups of weak piglets of embodiment serum IgG water It is flat to be higher than control group, significant difference (P < 0.05), wherein example 1 group, 2 groups of embodiment, 3 groups of embodiment, with 1 group of blood of example The horizontal highest of clear IgG antibody, but difference is not significant (P > 0.05) compared with other 2 groups, shows that Chinese herbal formula has Increase the effect of serum IgG antibody levels.
Influence of 2 Chinese herbal formula of table to diarrhea piglet hepatic and renal function
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 2, when off-test, example 1 group, 2 groups of embodiment, the liver function of 3 groups of weak piglets of embodiment (AST, ALT) and renal function (CREA, BUN) index are higher than control group, and significant difference (P < 0.05) shows Chinese herbal formula With diarrhea piglet kidney function indicator is reduced, have the function that kidney is protected in liver protection.
Influence of 3 Chinese herbal formula of table to diarrhea piglet serum protein levels
Note: the different letters of same column indicate significant difference (P<0.05), and same letter indicates that difference is not significant (P>0.05).
As shown in Table 3, example 1 group, 2 groups of embodiment, the total serum protein of 3 groups of embodiment and albumin level after test Higher than control group, but compared with the control group without significant difference (P > 0.05)；Example 1 group, 2 groups of embodiment, 3 groups of embodiment it is immune Globulin levels are significantly higher than control group (P < 0.05), wherein；2 groups of example of globulin levels highest is significantly higher than 1 group of example (P<0.05), but difference is not significant (P>0.05) compared with 3 groups of example, shows that Chinese herbal formula has and increases diarrhea piglet The effect of serum immune globulin.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.

Claims (2)

1. a kind of for treating the Chinese herbal formula of grice diarrhoea, it is characterised in that: according to parts by weight include Radix Codonopsis 10- 30 parts, 3-10 parts of Radix Astragali, 3-8 parts of radix bupleuri, 2-6 parts of Poria cocos, 1-3 parts of Herba Andrographitis, 1-5 parts of the coptis, 0.5-4.5 parts of Semen Arecae (parched), greatly It is 0.5-2 parts yellow, 1-3 parts of rhizoma atractylodis macrocephalae, 1-4 parts of dried orange peel, 1-3 parts of gypsum, 1-4 parts of meadowrueleaf corydalis root, 10-40 parts of dandelion, windproof 1-15 Part, 1-6 parts of radix glycyrrhizae preparata.
2. it is according to claim 1 a kind of for treating the preparation method of the Chinese herbal formula of grice diarrhoea, it is special Sign is, includes the following steps:
(1) Radix Codonopsis, Radix Astragali, Poria cocos, Semen Arecae (parched), rhizoma atractylodis macrocephalae, dried orange peel, radix saposhnikoviae, radix glycyrrhizae preparata etc. are mixed according to above-mentioned parts by weight meter Ultramicro grinding obtains Chinese medicine mixing Ultramicro-powder a；
(2) Herba Andrographitis, rheum officinale, the coptis, meadowrueleaf corydalis root etc. are mixed according to above-mentioned parts by weight meter and is pulverized as Chinese medicine mixing ultra micro Powder b；
(3) radix bupleuri, gypsum, dandelion are individually pulverized；
(4) after pulverizing, Chinese medicine mixing Ultramicro-powder a, radix bupleuri Ultramicro-powder, dandelion Ultramicro-powder are impregnated in 10 times of water respectively 1 hour；
(5) radix bupleuri Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 0.5 hour, by Chinese medicine mixing Ultramicro-powder A is put into after Chinese medicine extracting tank boils and is kept for slight boiling condition 1.5 hours, dandelion Ultramicro-powder is put into after boiling in Chinese medicine extracting tank It is kept for slight boiling condition 1 hour, gypsum Ultramicro-powder is put into after being boiled in Chinese medicine extracting tank and is kept for slight boiling condition 2 hours；
(6) tapping respectively, filtering, the dregs of a decoction continue to decoct after adding 4 times of water measured again according to above-mentioned steps, so three times, merge three Secondary filtrate；
(7) Chinese medicine mixing Ultramicro-powder b is put into Chinese medicine extracting tank, with 80% alcohol steep 1 hour of 20 times, extraction temperature was 80 DEG C, tapping is filtered, and the dregs of a decoction continue to extract after adding 15 times of 80% ethyl alcohol measured again according to above-mentioned steps, so three times, merges three Secondary filtrate；
(8) rotary evaporation recycles ethyl alcohol after extracting, and obtains medicinal extract, and gained medicinal extract Chinese medicine mixing Ultramicro-powder a extracting solution dissolves；
(9) all extracting solutions are mixed, it is 0.5g/mL that 50-60 DEG C, which is concentrated into crude drug concentration, and bottling sterilizes multiple to get Chinese herbal medicine Square preparation.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101905014A (en) * 2010-08-03 2010-12-08 中国农业科学院上海兽医研究所 Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets
CN104474082A (en) * 2014-11-26 2015-04-01 郑州后羿制药有限公司 Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method thereof
CN104840935A (en) * 2015-06-11 2015-08-19 大连民族大学 Traditional Chinese medicine patch for preventing piglet diarrhea as well as preparation method and application thereof
CN105233097A (en) * 2015-11-11 2016-01-13 郑州后羿制药有限公司 Veterinary-used traditional Chinese medicine composition for treating piglet diarrhea and preparation method thereof
CN108902462A (en) * 2018-04-28 2018-11-30 安徽金牧饲料有限公司 A kind of pannage that can be improved immunity and prevent and treat grice diarrhoea

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101905014A (en) * 2010-08-03 2010-12-08 中国农业科学院上海兽医研究所 Traditional Chinese medicine compound composition for treating diarrhea of weaned piglets
CN104474082A (en) * 2014-11-26 2015-04-01 郑州后羿制药有限公司 Traditional Chinese medicine composition for preventing and treating piglet diarrhea and preparation method thereof
CN104840935A (en) * 2015-06-11 2015-08-19 大连民族大学 Traditional Chinese medicine patch for preventing piglet diarrhea as well as preparation method and application thereof
CN105233097A (en) * 2015-11-11 2016-01-13 郑州后羿制药有限公司 Veterinary-used traditional Chinese medicine composition for treating piglet diarrhea and preparation method thereof
CN108902462A (en) * 2018-04-28 2018-11-30 安徽金牧饲料有限公司 A kind of pannage that can be improved immunity and prevent and treat grice diarrhoea

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