CN103393990B - Traditional Chinese medicine composition for preventing poultry kidney injuries and preparation method thereof - Google Patents
Traditional Chinese medicine composition for preventing poultry kidney injuries and preparation method thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for preventing poultry kidney injuries and a preparation method thereof. The traditional Chinese medicine composition is prepared from 11-13 parts of christina loosestrife, 5-7 parts of Japanese climbing fern spore and 7-9 parts of glabrous greenbrier rhizome by weight, and is prepared by a water extraction method. The preparation method is characterized by weighing the medicines according to parts by weight, adding water with weight 10-14 times the total weight of the medicines to decoct the medicines twice, 1.0-2.0 hours each time, filtering the decoction, merging the filtrate, filtering the filtrate when the filtrate is concentrated until the weight of the filtrate is 1-3 times the total weight of the medicines at reduced pressure, and filling and sterilizing the product, thus obtaining the traditional Chinese medicine composition. The components of the traditional Chinese medicine composition are mixed according to the traditional Chinese medicine compatibility theory, thus providing an effective medicine for preventing kidney injuries for the livestock and poultry industry. The traditional Chinese medicine composition is used for preventing poultry kidney injuries and reducing production performance reduction and death caused by kidney injuries.
Description
(1) art
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, particularly a kind ofly prevent and treat Chinese medicine composition of poultry kidney injury and preparation method thereof.
(2) background technology
Family poultry kidney injury be by multiple biology and abiotic factor cause with kidney enlargement, renal dysfunction, the abnormal accumulation of urate is a series of syndromes of principal character, main manifestations is renomegaly, pale, there is urate deposition in renal tubules and ureter, severe patient causes renal calculus and visceroatonia type, joint type gout.In recent years, at intensive farm and in raising scattered, the nephropathy incidence rate of chicken has the trend of rising, can cause the high mortality of chicken group, cause serious economic loss to poultry husbandry, become disease very important in production time serious.Because primary disease pathogenic factor is complicated, the medicine mainly taked at present is based on diuresis and suppress blood uric acid, as cinchophen, probenecid etc., can only alleviate clinical symptoms, cure the symptoms, not the disease.There is the problems such as toxic and side effects is large, drug residue due to this type of medicine, have impact on growth performance and the market value of poultry greatly, therefore exploitation have diuresis, detumescence, suppression urate deposition the nontoxic residue-free Chinese medicine compound of function extremely urgent.
Under herbal medicine theoretical direction, clearing away heat-damp and promoting diuresis can be selected for family's poultry kidney injury, detumescence calculus removing medicine carries out prescription, as " BAZHENG SAN ", " WULING SAN " recorded in veterinary drug allusion quotation etc., be used for treatment man poultry kidney injury disease by carrying out plus-minus to its prescription there is good curative effect clinically.Conventional medicament is when treating poultry kidney swelling and urate deposition, regulate body allomeric function to reach the object of disease therapy, reach treating both the principal and secondary aspects of a disease, and medicine used has no side effect, noresidue, therefore has good market prospect and application value.
(3) summary of the invention
Object of the present invention is exactly will provide a kind of to prevent and treat Chinese medicine composition of poultry kidney injury and preparation method thereof.
For achieving the above object, the present invention is realized by following technical scheme:
Prevent and treat a Chinese medicine composition for poultry kidney injury, be made up of Herba Lysimachiae, Spora Lygodii and Rhizoma Smilacis Glabrae, formula composition is expressed as by weight:
Herba Lysimachiae 11 ~ 13 parts, Spora Lygodii 5 ~ 7 parts, Rhizoma Smilacis Glabrae 7 ~ 9 parts.
The preparation method of the Chinese medicine composition of above-mentioned control poultry kidney injury, concrete preparation process is as follows:
(1) take Herba Lysimachiae 11 ~ 13 parts by weight, Spora Lygodii 5 ~ 7 parts, Rhizoma Smilacis Glabrae 7 ~ 9 parts be raw material;
(2) by above 3 taste Chinese medicines, add the water of medical material gross weight 10 ~ 14 times amount, decoct secondary, each 1.0 ~ 2.0 hours, filter, merging filtrate, obtains Aqueous extracts, and when filtrate reduced in volume is to medical material gross weight 1 ~ 3 times amount, filter, fill, sterilizing, to obtain final product.
The consumption of the Chinese medicine oral liquid of above-mentioned control poultry kidney injury is mix in drinking-water in the ratio of 0.2% (v/v), and allow chicken freely drink, being used in conjunction 5 ~ 7 days is a course for the treatment of.
Chinese medicine composition of the present invention, has effect of clearing away heat-damp and promoting diuresis, detumescence calculus, can be widely used in poultry urate deposition, death that kidney injury, reduction are caused by kidney injury.
Specific embodiment mode
Below in conjunction with specific embodiment, technical scheme of the present invention is further described.
Embodiment 1
Prevent and treat a Chinese medicine composition for poultry kidney injury, be made up of Herba Lysimachiae, Spora Lygodii and Rhizoma Smilacis Glabrae, wherein Herba Lysimachiae 120g, Spora Lygodii 60g, Rhizoma Smilacis Glabrae 80g.
The preparation method of the Chinese medicine composition of above-mentioned control poultry kidney injury, concrete preparation process is as follows:
(1) take Herba Lysimachiae 120g, Spora Lygodii 60g, Rhizoma Smilacis Glabrae 80g is raw material;
(2) by above 3 taste Chinese medicines, add the water of medical material gross weight 12 times amount, decoct secondary, each 1.5 hours, filter, merging filtrate, filter, filtrate reduced in volume is to 1000ml, and filter, fill, sterilizing, to obtain final product.
Embodiment 2
Take Herba Lysimachiae, Spora Lygodii, Rhizoma Smilacis Glabrae three taste Chinese medicine respectively, do not follow the proportion relation of this prescription Chinese crude drug, arbitrarily carry out prescription, prescription is Herba Lysimachiae 60g, Spora Lygodii 60g, Rhizoma Smilacis Glabrae 60g.
The preparation method of above-mentioned Chinese medicine composition, concrete preparation process is as follows:
(1) take Herba Lysimachiae 60g, Spora Lygodii 60g, Rhizoma Smilacis Glabrae 60g is raw material;
(2) by above 3 taste Chinese medicines, add the water of medical material gross weight 12 times amount, decoct secondary, each 1.5 hours, filter, merging filtrate, filter, filtrate reduced in volume is to 1000ml, and filter, fill, sterilizing, to obtain final product.
Embodiment 3
With reference to " a kind of oral liquid of instant renal calculus " (patent No.: 200910144779) compositing formula, wherein Cortex Cinnamomi 90g, Rhizoma Atractylodis Macrocephalae 150g, Polyporus 120g, Poria 120g, Rhizoma Alismatis 120g, Herba Lysimachiae 300g, Spora Lygodii 120g, Semen Abutili 120g, Rhizoma Anemarrhenae 120g, Fructus Forsythiae 100g, Radix Ginseng 120g, Radix Astragali 300g, Fructus Corni 150g, Radix Rehmanniae 200g, Radix Glycyrrhizae 600g.
The preparation method of above-mentioned Chinese medicine oral liquid, concrete preparation process is as follows:
(1) Cortex Cinnamomi 90g is taken, Rhizoma Atractylodis Macrocephalae 150g, Polyporus 120g, Poria 120g, Rhizoma Alismatis 120g, Herba Lysimachiae 300g, Spora Lygodii 120g, Semen Abutili 120g, Rhizoma Anemarrhenae 120g, Fructus Forsythiae 100g, Radix Ginseng 120g, Radix Astragali 300g, Fructus Corni 150g, Radix Rehmanniae 200g, Radix Glycyrrhizae 600g are raw material;
(2) above-mentioned medical material is put into boiling container, add water about 8L water, takes the fried liquid of about 1.6L, mixed in fried liquid by Gypsum Fibrosum 150g porphyrize powder, to obtain final product.
Clinical experiment report:
Chinese medicine oral liquid described in the embodiment of the present invention 1 ~ 3 is mixed in drinking-water in the ratio of 0.2% (v/v), allows chicken freely drink, be used in conjunction 7 days, after oral, reached the object of disease therapy by gastrointestinal absorption.
1. laboratory case: choose 400 100 ages in days " Roman egghen ", the modeling feedstuff of high protein of feeding, high calcium, every day restricts water supply in right amount, feeds continuously 7 days, preparation poultry kidney injury disease model.After kidney injury disease appears in chicken to be tested, change chow diet and feed, and start medication.Test chicken is divided at random model control group, embodiment 1 ~ 3 group, often organizes 100 test chickens; The test chicken separately getting 100 identical ages in days as normal healthy controls group, normal full price egg feedstuff of feeding.Concrete grouping and administrations are in table 1.
Table 1 tests grouping and administrations
Result of the test is as shown in table 2,
Table 2 poultry kidney injury prevention effect result of the test
Note: lower case difference represents significant difference (P < 0.05); Capitalization difference represents that difference extremely significantly (P < 0.01);
"-", without urate deposition, "+" urate deposition is obvious, and " ++ " urate deposition is more serious.
As can be seen from Table 2, the Chinese medicine oral liquid employing the extract oral liquor ratio embodiment 2,3 of embodiment 1 can reduce the poultry kidney swelling because modeling feedstuff of feeding causes extremely significantly, reduce renal index, also can obviously reduce uratic depositional phenomenon simultaneously, reduce mortality rate, for poultry body weightening finish, embodiment 1 also has extremely significant difference (P < 0.01) compared with embodiment 2,3, with normal healthy controls group there was no significant difference.Compared with embodiment 2, the proportion relation that this prescription uses is more effective, extremely significantly (P < 0.01) can reduce clinical symptoms; Compared with embodiment 3, this prescription uses medical material kind few, and effect is better, effectively prevents the waste of medicine, has saved a large amount of costs, can more scientific and effective treatment clinical symptoms.
2. natural cases: be selected from Deyang Tian Yun farm investment company limited chicken house, laying hen immune programme for children carries out vaccine immunity routinely.When 200 age in days, there is lethargy in chicken group, and feed intake reduces, thirst and liking drink, become thin, cockscomb is pale, dry by hair shaft, arranges white feces, the solids of tail feathers adhesion Calx slag specimen, egg diminishes, and egg production drops to 50% by 90%, occurs Mortality situation.Through Clinical anatomic and after carrying out laboratory diagnosis, get rid of other diseases factor, judge kidney injury occurs.
Being divided into 4 groups at random by being diagnosed as the chicken suffering from kidney injury, being respectively embodiment 1,2,3 treatment group and blank group.And give Chinese medicine oral liquid described in embodiment 1 ~ 3 in the ratio drinking-water of 0.2% (v/v), use 7 days continuously; Blank group does not do any process.Daily management and immune programme for children are undertaken by chicken house routine, continue observation 1 week after drug withdrawal.
Table 3 respectively organizes clinical setting and the fertility performance change of test chicken
Note: lower case difference represents significant difference (P < 0.05); Capitalization difference represents that difference extremely significantly (P < 0.01);
"-", without urate deposition, "+" urate deposition is obvious, and " ++ " urate deposition is more serious.
As can be seen from Table 3, each medication group laying rate all comparatively blank group has extremely significantly rising (P < 0.01), but embodiment 1 pair of laying rate promotes and compares with other embodiment, still there is pole significant difference (P < 0.01), illustrate that embodiment 1 effectively can promote laying rate; Duration of test, blank group is owing to treating its mortality rate in extremely remarkable ascendant trend (P < 0.01), the mortality rate that embodiment is 1 ~ 3 group is also controlled, and compare with embodiment 2,3, embodiment 1 obviously can reduce mortality rate; Embodiment 1,2,3 all can reduce feedstuff-egg ratio, but embodiment 1 can reduce feedstuff-egg ratio (P < 0.01) extremely significantly; Compbined test illustrates that embodiment 1 can improve the laying rate of kidney injury laying hen, reduces mortality rate.
Comprehensive above clinical trial, can illustrate that this Chinese medicine composition has effect of clearing away heat-damp and promoting diuresis, detumescence calculus, can be widely used in control poultry kidney injury, reduce the death and fertility performance decline that are caused by kidney injury.
Claims (3)
1. prevent and treat a Chinese medicine composition for poultry kidney injury, formula composition is expressed as by weight:
Herba Lysimachiae 11 ~ 13 parts, Spora Lygodii 5 ~ 7 parts, Rhizoma Smilacis Glabrae 7 ~ 9 parts.
2. the Chinese medicine composition of control poultry kidney injury according to claim 1, it is characterized in that, the preparation method of described Chinese medicine is as follows:
Take each medical material by described weight ratio, add the water of medical material gross weight 10 ~ 14 times amount, decoct secondary, each 1.0 ~ 2.0 hours, filter, merging filtrate, when filtrate reduced in volume is to medical material gross weight 1 ~ 3 times amount, filter, fill, sterilizing, to obtain final product.
3. the Chinese medicine composition of control poultry kidney injury according to claim 1, is characterized in that with above-mentioned Chinese medicine composition for raw material is prepared into oral liquid, powder, granule.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280837A (en) * | 2000-07-22 | 2001-01-24 | 李炳新 | Medicine for treating renal calculus and its preparing process |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280837A (en) * | 2000-07-22 | 2001-01-24 | 李炳新 | Medicine for treating renal calculus and its preparing process |
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