CN103190547A - Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs - Google Patents
Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs Download PDFInfo
- Publication number
- CN103190547A CN103190547A CN2013101359534A CN201310135953A CN103190547A CN 103190547 A CN103190547 A CN 103190547A CN 2013101359534 A CN2013101359534 A CN 2013101359534A CN 201310135953 A CN201310135953 A CN 201310135953A CN 103190547 A CN103190547 A CN 103190547A
- Authority
- CN
- China
- Prior art keywords
- chinese herbal
- parts
- feed additive
- weight
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
The invention discloses a Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs, and belongs to the technical field of feed additives. The Chinese herbal medicine feed additive takes Chinese herbal medicines including cortex acanthopanacis, platycodon grandiflorum, common cephalanoplos herbs, rhizoma cyperi, asparagus cochinchinensis, liquorice and the like as main raw materials, and is respectively prepared by using different preparation methods; the effective components in the Chinese herbal medicines are extracted to the utmost extent and are scientifically compounded with carefully prepared cordyceps sinensis mycelium powder, so that the Chinese herbal medicine feed additive can be prepared; and after the Chinese herbal medicine feed additive is added into feed, the immunity of the pigs easting the feed with the additive can be effectively improved, the primary pathogens and the secondary pathogens which can cause the comprehensive respiratory diseases of the pigs are remarkably inhibited, and the comprehensive respiratory diseases of the pigs can be effectively prevented and treated by the Chinese herbal medicine feed additive. Furthermore, effective active substances in the components of the composition can effectively improve the immunity of the pigs, improve the health degree of the pigs, promote the growth of the pigs and improve the economic benefits.
Description
Technical field
The invention belongs to field of feed additive technology, specifically is a kind of Chinese herbal feed additive of effective control pig synthetic respiratory disease.
Background technology
Pig synthetic respiratory disease generally takes place on the pig farm, though overall mortality rate is not high, the anorexia of ill pig, efficiency of feed utilization reduce, cough, expiratory dyspnea, speed of growth reduction etc., thus have a strong impact on the economic benefit on pig farm.The generation of pig synthetic respiratory disease is normally multifactor to be caused, its pathogenesis mainly contains: 1, primary cause of disease: often be that several cause of diseases exist simultaneously, as pig breeding and breathing syndrome virus, be commonly called as " blue otopathy ", mycoplasma pneumoniae, pig circular ring virus II type, pseudorabies virus, swine influenza virus, actinobacillus pleuropneumoniae etc.; 2, Secondary cases cause of disease: after pig has infected the primary cause of disease, because resistance and immunity degradation and secondary, common Secondary cases cause of disease has: relevant respiratory symptom diseases such as Streptococcus suis, the secondary haemophilus of pig, pasteurella multocida, toxoplasm, eperythrozoon, CSFV; 3, ventilated bad in the bad environment condition,, house too big as stocking density.
Common antibiotics class drug therapy at present easily produces drug resistance, and abuse of antibiotics causes the appearance of " superbacteria ", and the harm of mycotoxin increases the weight of, and the pollution of feeding environment, thinks little of the foundation of bio-safety system etc.Cause epidemic situation constantly all the year, present the pathogen diversification clinically, illness is complicated, brings many new problems not only for the prevention and control of eqpidemic disease, and has caused great economic loss.The basic reason that the problems referred to above take place is that hypoimmunity causes in the swinery, improves pig specific immunity and non-specific immunity only and just becomes the key point of dealing with problems.
In recent years, Chinese herbal feed additive has become a big focus of animal health research, develop Chinese herbal feed additive energetically to solving the antibiotic residue problem, boost productivity, develop green animal husbandry, satisfy people's food security demand, dwindle China's animal husbandry and developed country's gap, strengthen China's livestock products in the competitiveness of international market, have important economic implications and social benefit.Studies show that, many Chinese herbal medicines itself just have good external bacteriostasis, different with Western medicine is, Chinese herbal feed antibiotic health care agent noresidue, have no drug resistance, its mechanism of action not only is the inhibitory or killing effect to pathogenic microorganism, the more important thing is the adjustment to the body disease-resistant repair ability, namely improve anti-stress ability, raising body's immunity and the disease-resistant defensive enginery of body, thereby reach the purpose that improves breeding performonce fo animals and food utilization efficiency.
The objective of the invention is to develop with the Chinese herbal medicine Chinese herbal feed additive of the effective control pig synthetic respiratory disease that is primary raw material, being described below of some herbal raw materials:
Lucid asparagus: its medicinal part mainly is the piece root, have replenishing the vital essence and removing heat, moisturize the effect of promoting the production of body fluid, modern pharmacology studies show that symptoms such as pulmonary tuberculosis, bronchitis, diphtheria, pertussis, dry mouth and throat are had good curative effect, also has antibacterial immunity and anti-oxidation function simultaneously.Lucid asparagus contains asparagine, B-sitosterol, steroid saponin, compositions such as mucilaginous substance, furfural derivatives.Experiment showed, that lucid asparagus has the effect of hemocytes increasing, enhancing reticuloendothelial system phagocytic function and prolongation antibody life period." Mingyi Bielu " carries " cold removing heat is supported skin, beneficial strength "." moonlight is in book on Chinese herbal medicine " carries " beneficial skin is pleased color for relieving palpitation, moisturizing viscera ".Can make skin gorgeous, retain youthful vitality.
Balloonflower root: be China's traditional Chinese medicine, food medicine dual-purpose.With a surname lung, relieve sore throat, eliminate the phlegm, function such as apocenosis is widely used in the various prescriptions.Its chemical composition is mainly the oleanolic acid type pentacyclic triterpene saponin except polysaccharide, other still contain compounds such as flavones, carbene, steroidal, phenolic acid, aliphatic acid.There are some researches show that the water extract of balloonflower root has good in-vitro anti-inflammatory antimicrobial activity; Its active component platycodin has relieving cough and reducing sputum effect, antioxidation, has strong anti respiratory syncytial virus active function; Platycodon root polysaccharide is a kind of effective polysaccharide immunomodulator, can significantly increase polyclone IgM production of antibodies in the B cell, improves the immunity of body.
Field thistle: be the dry aerial parts of feverfew field thistle, have effects such as the swollen sore of cooling blood and hemostasis, eliminating stasis to resolve swelling, dysentery, be one of medicine commonly used of successive dynasties tcm clinical practice.Herb contains alkaloid, choline, saponin etc., has significant effects of antiinflammation and bacteriostasis.Its ethanol preserved material 1: 30000 o'clock is inhibited to the Mycobacterium hominis.
Rhizoma cyperi: different name sparrow head perfume (or spice), cyperi rhizoma etc. are the dry rhizome of sedge nutgrass flatsedge.Mainly contain the volatile oil composition, in addition, also have carbohydrate, alkaloid etc.Its triterpene compound has significant antiinflammatory action, and volatile oil component has inhibitory action to staphylococcus aureus.
Cortex acanthopanacis: have the effect that diffusing wind clearing damp, inducing diuresis for removing edema, liver and kidney benefiting strengthen the bone.Modern pharmacology shows that cortex acanthopanacis has effects such as significant anti-anoxic, antifatigue, maincenter inhibition; Its polysaccharide component participates in the humoral immunity of body, can excite T, the biological function of bone-marrow-derived lymphocyte.Contain Syringin (syringin), Eleutheroside B 1[eleutheroside B1; Isofraxidin-α-D-
GlucoseGlucoside (isofraxidin-α-D-glucoside)],
Stearic acid(stearic acid), sesamin (dsesamin), b-sitosterol, ligustrin (syringin), b-sitosterol glycoside (b-sitosterol glucoside), eleutherosideB1,16a-hydroxy (one)-kauran-19-oic acid, kaurenoic acid. other contains volatile oil and resin.
Cordyceps sinensis [Cordyceps sinensis (Berk.) Sacc.] belongs to Ascomycotina, Clavicipitaceae, Cordyceps, is the famous and precious Chinese herbal medicine class fungi of China's tradition, have the title of " king of medicine ", and its value is higher than genseng and pilose antler.Cordyceps sinensis is listed in first of the nourishing medicine always for thousands of years.Over nearly 20 years, carried out the research of the Cordyceps sinensis correlation function factor both at home and abroad in a deep going way, the significant curative effect of Cordyceps sinensis is familiar with by people just gradually.Cordyceps sinensis is distinguished the flavor of sweet warm in nature, has beneficial lung kidney, mends marrow, effects such as hemostasis and phlegm, cures mainly symptoms such as consumptive disease hemoptysis, night sweat void are breathed heavily, soreness of waist and knee joint.Studies show that: the aweto mycelium of fermenting and producing is similar with the natural cordyceps effect, and both all are rich in function factors such as Chinese caterpillar fungus polysaccharide, amino acid, sweet mellow wine and cordycepin.Chinese caterpillar fungus polysaccharide is a kind of baroque macromolecular compound, has obvious antineoplastic, also is desirable immunopotentiator; Cordycepin has obvious curative effects to the human body bronchiectasis; Sweet mellow wine has the diuresis function.Also contain the rich functions factor in the Cordyceps fermented liquid.
Summary of the invention
Technical problem solved by the invention is to use the traditional medicine theory of the traditional Chinese medical science, adopt composite Chinese herbal medicine form to add in the feed, can effectively strengthen the immunity of pig, primary cause of disease and the Secondary cases cause of disease that causes pig synthetic respiratory disease had significant inhibitory effect, can effectively prevent and treat the generation of porcine respiratory disease, improve the health degree of pig, promote the pig growth, increase economic efficiency.
In order to achieve the above object, the present invention is by the following technical solutions:
A kind of Chinese herb feed additive of effective control pig synthetic respiratory disease, formed by the raw material of following parts by weight:
Plant polyose powder 15-25 part, Herba Cirsii extract 8-15 part, rhizoma cyperi crushed material 5-10 part, lucid asparagus crushed material 6-10 part, Radix Platycodonis extract 10-30 part, mycelium powder of sinensis 10-25 part, licorice powder 2-5 part.
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are pulverized and mixed, after crossing the 30-50 mesh sieve, add 3-6 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 0.15%～3% of mixture total weight, pH is adjusted into 56, and hydrolysis temperature is 4560 ℃, and enzymolysis time is 1-3h, filter to get filtrate behind the enzymolysis, improve temperature to 75-85 ℃, keep 2-6h, cool to 30-45 ℃, add filtrate weight 2-4 ethanol doubly, kept collecting precipitation, the dry plant polyose powder that obtains 1-3 hour.Described concentration of alcohol is 8090%.
Described cortex acanthopanacis and balloonflower root mix with any mass ratio;
The preferred mass ratio of described cortex acanthopanacis and balloonflower root is 1: 1-2;
Described Herba Cirsii extract preparation method: after crossing the 20-40 mesh sieve after field thistle is pulverized, adding 3-6 times of weight alcohol dipping of field thistle extracts, 30-45 ℃ of temperature of control, adjust temperature after 2-4 hour and be 55-60 ℃ 1-2 hour, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 7585%;
Described Radix Platycodonis extract preparation method: after crossing the 20-40 mesh sieve after balloonflower root is pulverized, adding 3-6 times of weight water adjustment of balloonflower root temperature is 65-80 ℃ of dipping extraction 1-2 hour, and extract concentrates, drying obtains Radix Platycodonis extract;
Described Chinese caterpillar fungus hypha powder, preparation method thereof is as follows: Cordyceps Militaris is cultivated through inoculation fermentation and is obtained zymotic fluid, and fermented liquid spray drying obtains mycelium powder of sinensis.
Described Cordyceps Militaris fermentation medium percentage by weight consists of: sucrose 5%, glucose 2%, Radix Isatidis 2%, cortex acanthopanacis 0.51%, peptone 0.4%, soyabean protein powder 0.6%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.1%, the insufficient section pure water is supplied, pH6.0.
The preparation method of feed addictive of the present invention is as follows:
According to the raw material composition plant polyose powder, Herba Cirsii extract, rhizoma cyperi crushed material, lucid asparagus crushed material, Radix Platycodonis extract, mycelium powder of sinensis and licorice powder are mixed namely.
The addition of product of the present invention in the growth swine rations is 500-1000 gram/ton;
Beneficial effect:
Studies show that the water extract of balloonflower root has good in-vitro anti-inflammatory antimicrobial activity; Its active component platycodin has relieving cough and reducing sputum effect, antioxidation, has strong anti respiratory syncytial virus active function; Platycodon root polysaccharide is a kind of effective polysaccharide immunomodulator, can significantly increase polyclone IgM production of antibodies in the B cell, improves the immunity of body; Cortex acanthopanacis contains Syringin, Eleutheroside B 1, Isofraxidin-α-D-
GlucoseGlucoside,
Stearic acid, sesamin, b-sitosterol, ligustrin, b-sitosterol glycoside, kaurenoic acid; Contain lucid asparagus, balloonflower root, field thistle, rhizoma cyperi, cortex acanthopanacis in this Chinese medicine composition, the plant polyose powder that adds in the feed addictive, Herba Cirsii extract, Radix Platycodonis extract adopt diverse ways to extract the useful components such as polysaccharide in the plant respectively, make product merge the effective active composition of above-mentioned several materials, make product have good result by scientific matching simultaneously; Added mycelium powder of sinensis in the product, mycelium powder of sinensis has effectively absorbed the active component of Radix Isatidis and cortex acanthopanacis during the fermentation, above-mentioned composition has been realized the useful stack of component curative effect, and the invention product has effective prevention effect to pig synthetic respiratory disease shape; Ill pig is had good result for the treatment of, improve the immunity of pig simultaneously.This Chinese medicine composition can effectively strengthen the immunity of growth pig, improves its enantiopathy ability.
The specific embodiment
Form and technology below by specific embodiment narration product of the present invention.Unless stated otherwise, used technological means is method known in those skilled in the art among the present invention.In addition, embodiment is interpreted as illustrative, but not limits the scope of the invention, and the spirit and scope of the invention are only limited by claims.To those skilled in the art, under the prerequisite that does not deviate from essence of the present invention and scope, various changes or change that separation and Extraction condition in these embodiments is carried out also belong to protection scope of the present invention.
The used aweto strain of the present invention is purchased in Chinese industrial microorganism fungus kind preservation center, and culture presevation number is CICC14016.
The Cordyceps Militaris preparation of fermentation liquid:
(1) first order seed is cultivated: the Cordyceps sinensis slant strains is inserted in 500 ml shake flasks 100 milliliters of culture medium loading amounts, 180 rev/mins of rotary shaking tables, 24 ℃ of cultivation temperature, incubation time 50 hours;
(2) secondary seed is cultivated: first order seed is inserted 500 milliliters of secondary seeds according to 10% inoculum concentration shake in the bottle, condition of culture is identical with first order seed;
(3) three grades of seed culture: secondary seed is inserted 5000 milliliters of three grades of seeds with 10% inoculum concentration shake in the bottle 1000 milliliters of culture medium loading amounts, 100 rev/mins of rotary shaking tables, 24 ℃ of cultivation temperature, incubation time 50 hours;
(4) first class seed pot is cultivated: it is the first class seed pot of 150L that three grades of seeds are inserted total measurement (volume) with 10% inoculum concentration, fermentation medium loading amount 100L, 24 ℃ of cultivation temperature, 150 rev/mins of mixing speeds, ventilation (V/V) 1: 0.5, tank pressure 0.05Mpa, incubation time 48 hours;
(5) the secondary seed jar is cultivated: it is 1.5 tons of secondary seed jars that the first class seed pot bacterial classification is inserted total measurement (volume) with 10% inoculum concentration, 1 ton of fermentation medium loading amount, and condition of culture is identical with first class seed pot;
(6) fermentation tank culture: it is 13 tons fermentation tank that the bacterial classification in the secondary seed jar is inserted total measurement (volume) with 10% inoculum concentration, 10 tons of fermentation medium loading amounts, 24 ℃ of cultivation temperature, 100 rev/mins of mixing speeds, ventilation (V/V) 1: 0.4, tank pressure 0.05MPa, incubation time 72 hours.
Fermented liquid spray drying obtains mycelium powder of sinensis.
Xu Jin hall volume " Chinese medicinal fungi " is seen in the cultivation of Cordyceps sinensis fungi liquid submerged fermentation liquid among the present invention.
Slant medium percentage by weight of the present invention consists of: potato (liquor) 20%, and glucose 2%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, agar 2.0%, the insufficient section pure water is supplied.
First order seed, secondary seed, three grades of seeds, first class seed pot, secondary seed jar culture medium percentage by weights compositions are among the present invention: sucrose 5%, glucose 2%, peptone 0.4%, soyabean protein powder 0.6%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.1%, the insufficient section pure water is supplied, pH6.0.
Described Cordyceps Militaris fermentation medium consists of: percentage by weight, sucrose 5%, glucose 2%, Radix Isatidis 2%, cortex acanthopanacis 0.8%, peptone 0.4%, soyabean protein powder 0.6%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.1%, the insufficient section pure water is supplied, pH6.0.
Embodiment 1
(1) a kind of Chinese herb feed additive of effective control pig synthetic respiratory disease is made up of the raw material of following parts by weight: 18 parts in plant polyose powder, 9 parts of Herba Cirsii extracts, 7 parts of rhizoma cyperi crushed materials, 8 parts of lucid asparagus crushed materials, 20 parts of Radix Platycodonis extracts, 17 parts of mycelium powder of sinensis, 4 parts of licorice powders.
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are to be pulverized and mixed at 1: 1 by mass ratio, after crossing 30 mesh sieves, add 3 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 3% of (before adding water) mixture total weight, pH is adjusted into 5, and hydrolysis temperature is 60 ℃, and enzymolysis time is 1h, filter to get filtrate behind the enzymolysis, improve temperature to 85 ℃, keep 3h, cool to 45 ℃, add the ethanol of 3 times of filtrate weight, kept collecting precipitation, the dry plant polyose powder that obtains 2 hours.Concentration of alcohol 85%.
Described Herba Cirsii extract preparation method: field thistle is pulverized after the back crosses 30 mesh sieves, add 3 times of weight alcohol dipping of field thistle and extract, 30 ℃ of control temperature, adjust temperature after 2 hours and be 55 ℃ 2 hours, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 75%;
Described Radix Platycodonis extract preparation method: after crossing 20 mesh sieves after balloonflower root is pulverized, adding 3 times of weight water adjustment of balloonflower root temperature is 70 ℃ of dipping extractions 2 hours, and extract concentrates, drying obtains Radix Platycodonis extract;
(2) preparation method: mix namely after above-mentioned raw materials got material by weight.
Embodiment 2
(1) a kind of Chinese herb feed additive of effective control pig synthetic respiratory disease, formed by the raw material of following parts by weight:
21 parts in plant polyose powder, 11 parts of Herba Cirsii extracts, 6 parts of rhizoma cyperi crushed materials, 9 parts of lucid asparagus crushed materials, 21 parts of Radix Platycodonis extracts, 20 parts of mycelium powder of sinensis, 5 parts of licorice powders.
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are to be pulverized and mixed at 1: 1.5 by mass ratio, after crossing 50 mesh sieves, add 4 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 2% of mixture total weight, pH is adjusted into 5, and hydrolysis temperature is 55 ℃, and enzymolysis time is 2h, filter to get filtrate behind the enzymolysis, improve temperature to 80 ℃, keep 4h, cool to 40 ℃, add the ethanol of 4 times of filtrate weight, kept collecting precipitation, the dry plant polyose powder that obtains 3 hours.Concentration of alcohol 80%.
Described Herba Cirsii extract preparation method: field thistle is pulverized after the back crosses 20 mesh sieves, add 4 times of weight alcohol dipping of field thistle and extract, 35 ℃ of control temperature, adjust temperature after 4 hours and be 60 ℃ 2 hours, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 80%;
Described Radix Platycodonis extract preparation method: after crossing 30 mesh sieves after balloonflower root is pulverized, adding 5 times of weight water adjustment of balloonflower root temperature is 65 ℃ of dipping extractions 2 hours, and extract concentrates, drying obtains Radix Platycodonis extract;
(2) preparation method: with embodiment 1.
Embodiment 3
(1) a kind of Chinese herb feed additive of effective control pig synthetic respiratory disease, formed by the raw material of following parts by weight:
23 parts in plant polyose powder, 13 parts of Herba Cirsii extracts, 5 parts of rhizoma cyperi crushed materials, 7 parts of lucid asparagus crushed materials, 18 parts of Radix Platycodonis extracts, 15 parts of mycelium powder of sinensis, 4 parts of licorice powders.
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are to be pulverized and mixed at 1: 1.8 by mass ratio, after crossing 40 mesh sieves, add 5 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 1.5% of mixture total weight, pH is adjusted into 6, and hydrolysis temperature is 50 ℃, and enzymolysis time is 2h, filter to get filtrate behind the enzymolysis, improve temperature to 80 ℃, keep 5h, cool to 35 ℃, add the ethanol of 4 times of filtrate weight, kept collecting precipitation, the dry plant polyose powder that obtains 3 hours.Concentration of alcohol 90%
Described Herba Cirsii extract preparation method: field thistle is pulverized after the back crosses 40 mesh sieves, add 5 times of weight alcohol dipping of field thistle and extract, 45 ℃ of control temperature, adjust temperature after 3 hours and be 60 ℃ 2 hours, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 85%;
Described Radix Platycodonis extract preparation method: after crossing 40 mesh sieves after balloonflower root is pulverized, adding 4 times of weight water adjustment of balloonflower root temperature is 70 ℃ of dipping extractions 2 hours, and extract concentrates, drying obtains Radix Platycodonis extract;
(2) preparation method: with embodiment 1.
Embodiment 4
(1) a kind of Chinese herb feed additive of effective control pig synthetic respiratory disease, formed by the raw material of following parts by weight:
20 parts in plant polyose powder, 14 parts of Herba Cirsii extracts, 9 parts of rhizoma cyperi crushed materials, 10 parts of lucid asparagus crushed materials, 27 parts of Radix Platycodonis extracts, 21 parts of mycelium powder of sinensis, 3 parts of licorice powders.
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are to be pulverized and mixed at 1: 2 by mass ratio, after crossing 45 mesh sieves, add 6 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 1% of mixture total weight, pH is adjusted into 6, and hydrolysis temperature is 45 ℃, and enzymolysis time is 3h, filter to get filtrate behind the enzymolysis, improve temperature to 75 ℃, keep 6h, cool to 30 ℃, add the ethanol of 3 times of filtrate weight, kept collecting precipitation, the dry plant polyose powder that obtains 2 hours.Concentration of alcohol 80%
Described Herba Cirsii extract preparation method: field thistle is pulverized after the back crosses 40 mesh sieves, add 6 times of weight alcohol dipping of field thistle and extract, 45 ℃ of control temperature, adjust temperature after 4 hours and be 60 ℃ 2 hours, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 85%;
Described Radix Platycodonis extract preparation method: after crossing 40 mesh sieves after balloonflower root is pulverized, adding 6 times of weight water adjustment of balloonflower root temperature is 80 ℃ of dipping extractions 2 hours, and extract concentrates, drying obtains Radix Platycodonis extract;
(2) preparation method: with embodiment 1.
Adopt the Chinese herb feed additive of effective control pig synthetic respiratory disease of embodiment 1 preparation to do following checking.
Test method:
It is 120 of the healthy weanling pigs of (7.21 ± 0.15) kg that experimental animal is selected subordinate plant of twins (group) limited company average weight, and it is not remarkable to analyze body weight difference by statistics.Adopt the single-factor Randomized Designs, with 120 healthy weanling pigs, by male and female half and half, be divided into 2 groups (control group and test group), every group of 6 repetitions, each repeats 10 pigs.Test group is added the product of the present invention that embodiment 1 makes, and control group does not add product of the present invention.Fed continuously 15 days, and compared with control group, use the invention feed addictive can obtain following effect:
| Project | Control group | Test group | Remarks |
| Starting weight (kg) | 7.19 | 7.23 | ? |
| End heavy (kg) | 10.86 | 11.64 | ? |
| Daily gain (g/d head) | 244.7 | 294 | ? |
| Daily ingestion amount (g/d head) | 337.7 | 367.5 | ? |
| Feedstuff-meat ratio | 1.38 | 1.25 | ? |
| The breathing problem incidence of disease (%) | 31.4 | 4.2 | ? |
Result of the test shows, adds this product in the weanling pig daily ration, and the daily gain of piglet improves a lot than control group; Feedstuff-meat ratio has obvious reduction; The breathing problem incidence of disease significantly reduces.
The result of use test of example 1 feed addictive of the present invention in milking sow
Carried out 21 days feeding experiment by a definite date on twins (group) limited company subordinate pig farm.Single factor contrast design is adopted in test, and the milking sow 30 health of picked at random, that a farrowing number is close with the birth counterpoise, that parity is 2 or 3 tires is divided into 2 groups (being test group and control group), every group of 15 repetitions at random.Wherein: the test group daily ration adds this product that is prepared into by embodiment 1, and control group does not add product of the present invention.Record weaned piglet weight, the death rate and the breathing problem incidence of disease.
| Project | Test group | Control group | Remarks |
| The average young number (number) of living that produces | 10.8 | 11.0 | ? |
| Birth counterpoise (kg) | 1.46 | 1.48 | ? |
| 21 days average weanling pigs (head) | 10 | 9 | ? |
| Death rate % | 7.4 | 18.2 | ? |
| 21 days weight of weaning litters (kg) | 74.5 | 64.1 | ? |
| 21 days wean counterpoises (kg) | 7.45 | 7.12 | ? |
| The breathing problem incidence of disease (%) | 3.2 | 26.3 | ? |
Result of the test shows, adds this product in the milking sow daily ration, and the weight ratio control group that produces porkling improves a lot; The piglet breathing problem incidence of disease significantly reduces.
More than two example tests show: product of the present invention can improve sow and piglet body immunity, significantly reduces the breathing problem incidence of disease of piglet, improves and cultures quality and benefits.
Claims (10)
1. effective Chinese herbal feed additive of control pig synthetic respiratory disease, formed by the raw material of following parts by weight:
Plant polyose powder 15-25 part, Herba Cirsii extract 8-15 part, rhizoma cyperi crushed material 5-10 part, lucid asparagus crushed material 6-10 part, Radix Platycodonis extract 10-30 part, mycelium powder of sinensis 10-25 part, licorice powder 2-5 part;
Described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are pulverized and mixed, after crossing the 30-50 mesh sieve, add 3-6 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 0.15%～3% of mixture total weight, pH is adjusted into 5-6, and hydrolysis temperature is 45-60 ℃, and enzymolysis time is 1-3h, filter to get filtrate behind the enzymolysis, improve temperature to 75-85 ℃, keep 2-6h, cool to 30-45 ℃, add filtrate weight 2-4 ethanol doubly, kept collecting precipitation, the dry plant polyose powder that obtains 1-3 hour;
Described Chinese caterpillar fungus hypha powder, preparation method thereof is as follows: Cordyceps Militaris is cultivated through inoculation fermentation and is obtained zymotic fluid, and fermented liquid spray drying obtains mycelium powder of sinensis; Described Herba Cirsii extract preparation method is: after crossing the 20-40 mesh sieve after field thistle is pulverized, adding 3-6 times of weight alcohol dipping of field thistle extracts, 30-45 ℃ of temperature of control, adjust temperature after 2-4 hour and be 55-60 ℃ 1-2 hour, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 75-85%;
Described Radix Platycodonis extract preparation method is: after crossing the 20-40 mesh sieve after balloonflower root is pulverized, adding 3-6 times of weight water adjustment of balloonflower root temperature is 65-80 ℃ of dipping extraction 1-2 hour, and extract concentrates, drying obtains Radix Platycodonis extract.
2. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1, it is characterized in that described Chinese caterpillar fungus fermentation culture medium percentage by weight consists of: sucrose 5%, glucose 2%, Radix Isatidis 2%, cortex acanthopanacis 0.8%, peptone 0.4%, soyabean protein powder 0.6%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.1%, the insufficient section pure water is supplied, pH6.0.
3. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1 is characterized in that described cortex acanthopanacis and balloonflower root mix with any mass ratio; The preferred mass ratio of described cortex acanthopanacis and balloonflower root is 1: 1-2.
4. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1, it is characterized in that described Chinese caterpillar fungus fermentation culture medium percentage by weight consists of: sucrose 5%, glucose 2%, Radix Isatidis 2%, cortex acanthopanacis 0.8%, peptone 0.4%, soyabean protein powder 0.6%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.1%, the insufficient section pure water is supplied, pH6.0.
5. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1, it is characterized in that, described Chinese herb feed additive, raw material by following parts by weight is formed: 18 parts in plant polyose powder, 9 parts of Herba Cirsii extracts, 7 parts of rhizoma cyperi crushed materials, 8 parts of lucid asparagus crushed materials, 20 parts of Radix Platycodonis extracts, 17 parts of mycelium powder of sinensis, 4 parts of licorice powders.
6. as claim 1 or 5 described one one kinds of Chinese herbal feed additives of effectively preventing and treating pig synthetic respiratory disease, it is characterized in that, described plant polyose powder, preparation method thereof is as follows: cortex acanthopanacis and balloonflower root are to be pulverized and mixed at 1: 1 by mass ratio, after crossing 30 mesh sieves, add 3 times of weight water of mixture, add mixed enzyme, mixed enzyme is acid pectase, neutral proteinase and cellulase, the weight proportion of three kinds of enzymes are 1: 1.5: 2.5, enzyme concentration is 3% of mixture total weight, pH is adjusted into 5, and hydrolysis temperature is 60 ℃, and enzymolysis time is 1h, filter to get filtrate behind the enzymolysis, improve temperature to 85 ℃, keep 3h, cool to 45 ℃, add the ethanol of 3 times of filtrate weight, kept collecting precipitation, the dry plant polyose powder that obtains 2 hours.
7. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1, it is characterized in that, Herba Cirsii extract preparation method: after crossing 30 mesh sieves after field thistle is pulverized, adding 3 times of weight alcohol dipping of field thistle extracts, 30 ℃ of control temperature, adjust temperature after 2 hours and be 55 ℃ 2 hours, extract concentrates, drying obtains Herba Cirsii extract; Described concentration of alcohol is 75%.
8. the Chinese herbal feed additive of a kind of effective control pig synthetic respiratory disease as claimed in claim 1, it is characterized in that, described Chinese herb feed additive, raw material by following parts by weight is formed: 21 parts in plant polyose powder, 11 parts of Herba Cirsii extracts, 6 parts of rhizoma cyperi crushed materials, 9 parts of lucid asparagus crushed materials, 21 parts of Radix Platycodonis extracts, 20 parts of mycelium powder of sinensis; 5 parts of licorice powders.
9. as the described a kind of effective preparation method who prevents and treats the Chinese herbal feed additive of pig synthetic respiratory disease of claim 1-8, comprise the steps: according to the raw material composition plant polyose powder, Herba Cirsii extract, rhizoma cyperi crushed material, lucid asparagus crushed material, Radix Platycodonis extract, mycelium powder of sinensis and licorice powder to be mixed namely.
10. the application of Chinese herbal feed additive in the growth swine rations of a kind of effective control pig synthetic respiratory disease as claimed in claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310135953.4A CN103190547B (en) | 2013-04-18 | 2013-04-18 | Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310135953.4A CN103190547B (en) | 2013-04-18 | 2013-04-18 | Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103190547A true CN103190547A (en) | 2013-07-10 |
| CN103190547B CN103190547B (en) | 2014-02-12 |
Family
ID=48713513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310135953.4A Active CN103190547B (en) | 2013-04-18 | 2013-04-18 | Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103190547B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445029A (en) * | 2013-09-21 | 2013-12-18 | 广南(湛江)家丰饲料有限公司 | Pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity |
| CN104171677A (en) * | 2014-08-02 | 2014-12-03 | 成都双胞胎饲料有限公司 | Pig feed additive for improving immunity and promoting growth |
| CN104905015A (en) * | 2014-03-10 | 2015-09-16 | 天津工业大学 | A compound feed additive and a preparation method thereof |
| CN105341417A (en) * | 2015-11-30 | 2016-02-24 | 山东绿都安特动物药业有限公司 | Feed additive for weaned pigs, capable of controlling respiratory diseases and improving immunity |
| CN105475651A (en) * | 2015-12-28 | 2016-04-13 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
| CN109362968A (en) * | 2018-11-07 | 2019-02-22 | 华中农业大学 | A kind of plant extract feed additive and application preventing and treating porcine respiratory disease and strengthen immunity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152465A (en) * | 2007-08-16 | 2008-04-02 | 张国香 | Method of preparing oral liquid for anti-fever and smoothing asthma of hyperpyrexia syndrome |
| CN102526455A (en) * | 2010-12-16 | 2012-07-04 | 天津中敖生物科技有限公司 | Livestock Chinese medicinal composition with lung-clearing and phlegm-eliminating functions and preparation method thereof |
| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
-
2013
- 2013-04-18 CN CN201310135953.4A patent/CN103190547B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101152465A (en) * | 2007-08-16 | 2008-04-02 | 张国香 | Method of preparing oral liquid for anti-fever and smoothing asthma of hyperpyrexia syndrome |
| CN102526455A (en) * | 2010-12-16 | 2012-07-04 | 天津中敖生物科技有限公司 | Livestock Chinese medicinal composition with lung-clearing and phlegm-eliminating functions and preparation method thereof |
| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Non-Patent Citations (4)
| Title |
|---|
| 张家恭: "呼吸道疾病综合症的发病机理与防控措施", 《养殖与饲料》, no. 9, 1 September 2008 (2008-09-01), pages 41 - 42 * |
| 易湘蓉 等: "中草药防治猪呼吸道疾病的研究", 《猪业科学》, no. 2, 25 February 2007 (2007-02-25), pages 26 - 29 * |
| 沈华伟: "中草药在防治猪呼吸道病综合症(PRDC)中的应用研究", 《动物科学与动物医学》, vol. 21, no. 11, 25 November 2004 (2004-11-25), pages 50 - 51 * |
| 马宁泽 等: "中草药防治猪呼吸道疾病的作用机理", 《养殖技术顾问》, no. 5, 5 May 2012 (2012-05-05), pages 226 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445029A (en) * | 2013-09-21 | 2013-12-18 | 广南(湛江)家丰饲料有限公司 | Pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity |
| CN103445029B (en) * | 2013-09-21 | 2014-05-28 | 广南(湛江)家丰饲料有限公司 | Pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity |
| CN104905015A (en) * | 2014-03-10 | 2015-09-16 | 天津工业大学 | A compound feed additive and a preparation method thereof |
| CN104171677A (en) * | 2014-08-02 | 2014-12-03 | 成都双胞胎饲料有限公司 | Pig feed additive for improving immunity and promoting growth |
| CN105341417A (en) * | 2015-11-30 | 2016-02-24 | 山东绿都安特动物药业有限公司 | Feed additive for weaned pigs, capable of controlling respiratory diseases and improving immunity |
| CN105475651A (en) * | 2015-12-28 | 2016-04-13 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
| CN109362968A (en) * | 2018-11-07 | 2019-02-22 | 华中农业大学 | A kind of plant extract feed additive and application preventing and treating porcine respiratory disease and strengthen immunity |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103190547B (en) | 2014-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102894207B (en) | Body-immunity-enhancing composite Chinese herbal medicine pig feed additive and preparation method thereof | |
| CN103190547B (en) | Chinese herbal medicine feed additive for effectively controlling comprehensive respiratory diseases of pigs | |
| CN101869220B (en) | Traditional herbal medicine feed addictive for preventing and controlling swine high fever syndrome | |
| CN100494341C (en) | Huishuhua fermentation preparation process using Chinese herb medicine as medium | |
| CN102669466B (en) | 21-42-days-old meat duck feed and preparation method thereof | |
| JP5000066B2 (en) | Conversion and modification of natural drugs by co-fermentative culture of intestinal symbiotic organisms | |
| CN103141702B (en) | Chinese herb extract feed additive capable of effectively preventing and treating porcine epizootic diarrhea | |
| CN104922586B (en) | A kind of preparation and its application of the probiotics fermention Chinese medicine preparation for preventing chicken coccidiasis | |
| CN105454661A (en) | Pig feed additive for enhancing immunity | |
| CN103125780A (en) | Compound Chinese herbal preparation for improving testudinate immunity | |
| CN105410346A (en) | Cultured penaeus vannamei survival rate improving traditional Chinese medicine preparation and preparation method thereof | |
| CN106165780A (en) | A kind of broiler Chinese medicine composite probiotics feed additive and preparation method thereof | |
| CN103976351B (en) | A kind of health food of develop immunitypty improving water flood and two-step fermentation preparation method thereof | |
| CN104739919A (en) | Fermented astragalus composite preparation as well as preparation method and application thereof | |
| CN102872392A (en) | Chinese medicinal preparation for preventing and controlling swine mycoplasma pneumonia and preparation method thereof | |
| CN103948023B (en) | The health food of a kind of develop immunitypty and improving water flood and two-step fermentation preparation method thereof | |
| CN103932181B (en) | A kind ofly to release the pressure and the functional food of Improving memory and two-step fermentation preparation method thereof | |
| CN108185140A (en) | Pueraria lobata composite fermentation object and its preparation method and application | |
| CN102058810B (en) | Lung-clearing asthma-relieving phlegm-reducing Chinese patent drug | |
| CN103083510A (en) | Chinese medicinal oral liquid for improving poultry immune function and its preparation method | |
| CN103932180B (en) | A kind ofly to release the pressure and the health food of antifatigue and two-step fermentation preparation method thereof | |
| CN104000192A (en) | Functional food for relieving stress and regulating intestines and stomach and two-step fermentation preparation method of functional food | |
| CN106306548B (en) | Feed additive for preventing and treating proventriculitis and myogastritis of chicken | |
| CN105617367A (en) | Livestock and poultry respiratory tract health promotion ferment and preparation method thereof | |
| CN103385368B (en) | Chinese medicine preparation for preventing and treating postpartum hypogalactia of sow and production method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160408 Address after: 517583 Huitong Industrial Park, butterfly Ling Industrial City, Dongyuan County, Heyuan, Guangdong Patentee after: Heyuan twin Feed Co., Ltd. Address before: 330096 twin (Group) Limited by Share Ltd, 999 torch street, Nanchang hi tech Zone, Jiangxi Patentee before: Twins (Group) Co., Ltd. |