CN103445029B - Pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity - Google Patents
Pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity Download PDFInfo
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Abstract
The invention discloses a pig feed additive capable of effectively preventing and treating respiratory diseases as well as improving immunity, belonging to the field of feed additives. The pig feed additive takes Chinese herbal medicines such as fructus forsythiae powder, mixed Chinese herbal medicine polysaccharides, a lonicera japonica leaf extract, radix bupleuri powder, astragalus powder, licorice powder, radix isatidis powder, mint powder, codonopsis powder, rhizoma atractylodis and fructus ligustri lucidi as main raw materials, meanwhile different preparation methods are adopted, and effective components in the Chinese herbal medicines are utilized to the maximum extent. According to the pig feed additive, the compatibility of various Chinese herbal medicines are scientific, and after the pig feed additive is added into the feed, the feed effectively prevents and treats respiratory diseases of pigs, also improves the immunity of the pigs simultaneously, improves the health degree of the pigs, promotes the growth of the pigs, and increases the economic benefits.
Description
Technical field
The present invention relates to a kind of pig's feed additive, especially relate to a kind of pig's feed additive of effectively preventing and treating breathing problem and strengthening epidemic disease power, belong to feed feed additive field.
Background technology
Porcine respiratory disease syndrome (porcine respiratory disease complex, PRDC) be a kind of multiple-factor disease, be by various bacteria, virus, mycoplasma, environmental stress and pig resistance reduce, the general name of factors the interacts breathing problem causing such as feeding and management condition is bad.Porcine respiratory disease is one of problem that puzzlement modernized pig raising industry is the most serious, it is except causing the direct death of pig, also increase treatment cost, reduce feed conversion rate, cause pig poor growth, anorexia, cough, expiratory dyspnea, postpone listing and the upper vicious circle of management etc., make Swine Production suffer heavy losses.The generation of pig synthetic respiratory disease is normally multifactor to be caused, its pathogenesis mainly contains: 1, primary cause of disease: be often that several cause of diseases exist simultaneously, as pig breeding and breathing syndrome virus, be commonly called as " blue otopathy ", mycoplasma pneumoniae, pig circular ring virus II type, pseudorabies virus, swine influenza virus, actinobacillus pleuropneumoniae etc.; 2, Secondary cases cause of disease: pig has infected after primary cause of disease, due to resistance and immunity degradation and secondary, common Secondary cases cause of disease has: the relevant respiratory symptom diseases such as Streptococcus suis, the secondary haemophilus of pig, pasteurella multocida, toxoplasm, eperythrozoon, CSFV; 3, bad environmental condition, as stocking density is too large, house is interior ventilated bad.
The at present main antibiotics treatment porcine respiratory disease that uses, a large amount of uses of antibiotics easily produce drug resistance, cause the appearance of " superbacteria " etc., also easily produce food-safety problem, affect health.Also can cause epidemic situation constantly all the year, present clinically pathogen diversification, illness is complicated simultaneously, brings many new problems not only to the prevention and control of epidemic disease, and has caused great economic loss.
Chinese herbal medicine is as natural products, there is multiple efficacies and abundant nutritional labeling, can not only effectively prevent and treat the generation of disease, and can get facilitation to growing of pig, can effectively improve the immunity of pig, the incidence study that reduces pig various diseases shows, many Chinese herbal medicines itself just have good In Vitro Bacteriostasis ability, different from Western medicine is, Chinese herbal feed antibiotic health care agent noresidue, have no drug resistance, its mechanism of action is not only the inhibitory or killing effect to pathogenic microorganism, the more important thing is the adjustment to body disease-resistant repair ability, improve the anti-stress ability of body, improve body's immunity and Defense response function, thereby reach the object that improves breeding performonce fo animals and food utilization efficiency.
Devoting Major Efforts To Developing Chinese herbal feed additive is to solving antibiotic residue problem, boost productivity, development stockbreeding industry, meet people's food security demand, dwindle China's animal husbandry and developed country's gap, strengthen the competitiveness of China's livestock products in international market, there is important economic implications and social benefit.
Summary of the invention
The object of the present invention is to provide a kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity.This additive can effectively be prevented and treated porcine respiratory disease, reduces the incidence of disease of porcine respiratory disease, and instant effect is effective; This additive can also strengthen pig immunity simultaneously, promotes pig growth, shortens marketing time, increases economic benefit and promotes culture efficiency.
The technical solution adopted for the present invention to solve the technical problems is:
Effectively prevent and treat a pig feed additive for breathing problem and enhancing immunity, it is characterized in that being formed by capsule of weeping forsythia powder, mixing polysaccharides of traditional Chinese medicine, leaf of Flos Lonicerae extract, radix bupleuri powder, astragalus membranaceus powder, licorice powder, Radix Isatidis powder, Herba Menthae powder, codonopsis pilosula powder, rhizoma atractylodis, the fruit of glossy privet and carrier.
Preferably, a kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity, every 100 parts are mixed by weight by following raw material: capsule of weeping forsythia powder 10-15 part, mixing polysaccharides of traditional Chinese medicine 8-12 part, leaf of Flos Lonicerae extract 2-3 part, radix bupleuri powder 2-4 part, astragalus membranaceus powder 3-4 part, licorice powder 2-4 part, Radix Isatidis powder 2-3 part, Herba Menthae powder 1-2 part, codonopsis pilosula powder 1-3 part, rhizoma atractylodis 2-3 part, fruit of glossy privet 1-2 part, all the other are carrier.
Preferred, a kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity, it is characterized in that every 100 parts are mixed by weight by following raw material: 13 parts, capsule of weeping forsythia powder, 11 parts of mixing polysaccharides of traditional Chinese medicines, 3 parts of leaf of Flos Lonicerae extract, 3 parts, radix bupleuri powder, 4 parts of astragalus membranaceus powders, 3 parts of licorice powders, 2 parts, Radix Isatidis powder, 1 part of Herba Menthae powder, 2 parts of codonopsis pilosula powder, 2 parts of rhizoma atractylodis, 1 part of the fruit of glossy privet, all the other are carrier.
The preparation method of described capsule of weeping forsythia powder: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and 1:5-8 adds deionized water by solid-liquid ratio, then add the mixed enzyme of 1-1.5%, maintain 40-60 ℃, keep stirring 1-1.5h, spraying dry, pulverize 60 mesh sieves, obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 2-3:1:1-3 in mass ratio.
The preparation method of described mixing polysaccharides of traditional Chinese medicine: by selected matrimony vine, aloe and ox paint, pulverized respectively 40 mesh sieves, matrimony vine in mass ratio: aloe: ox paint=3-5:2-3:1 mixes, add 12-18 times of deionized water, ultrasonic extraction 30-40min, extraction temperature is 60-80 ℃, ultrasonic power 120-140W, vacuum filtration; Filter residue adds 6-9 times of deionized water, ultrasonic extraction 20-30min, and extraction temperature is 60-80 ℃, ultrasonic power 120-140W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to ethanol solubility 76-85%, put into standing 2-3h under 6-10 ℃ of condition; Get precipitated liquid freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine.
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 2-3h by solid-liquid ratio 1:5-8, extract temperature 60-75 ℃, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 35-50 ℃;
(2) toward the ethanol that adds 68-85% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:8-15, ultrasonic extraction 30-40 minute, temperature 70-80 ℃, power 80-100 watt, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merge filtrate twice, be evaporated to the 1/6-1/7 of original volume;
(3) extract obtaining in (2) is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 2-3h, wash 2BV with water, flow velocity is 1BV/h, then use the ethanol elution 5BV of 60-72%, flow velocity is 1BV/h, and the spraying of collection ethanol eluate dry, pulverize 60 mesh sieves and obtains leaf of Flos Lonicerae extract.
Described radix bupleuri powder, preparation method thereof: radix bupleuri was pulverized to 60 mesh sieves;
Described astragalus membranaceus powder preparation method: the Radix Astragali was pulverized to 60 mesh sieves;
Described licorice powder preparation method: Radix Glycyrrhizae was pulverized to 60 mesh sieves;
Described Radix Isatidis powder, preparation method thereof: Radix Isatidis was pulverized to 60 mesh sieves;
Described Herba Menthae powder preparation method: peppermint was pulverized to 60 mesh sieves;
Described codonopsis pilosula powder preparation method: Radix Codonopsis was pulverized to 80 mesh sieves;
Described rhizoma atractylodis powder, preparation method thereof: rhizoma atractylodis were pulverized to 40 mesh sieves;
Described fruit of glossy privet powder, preparation method thereof: the fruit of glossy privet was pulverized to 40 mesh sieves;
Described carrier is the 2-3:1:4-5 mixing in mass ratio of defatted rice bran, zeolite powder and maize cob meal, pulverizes 40 mesh sieves;
The preparation method of feed addictive of the present invention is as follows: by capsule of weeping forsythia powder, mixing polysaccharides of traditional Chinese medicine, leaf of Flos Lonicerae extract, radix bupleuri powder, astragalus membranaceus powder, licorice powder, Radix Isatidis powder, Herba Menthae powder, codonopsis pilosula powder, rhizoma atractylodis, the fruit of glossy privet and carrier mix by proportioning.Addition in pig feed per ton is 1000-1600g.
Beneficial effect
The compatibility of above Chinese herbal medicine uses, and can prepare the pig's feed additive of effectively preventing and treating breathing problem and strengthening immunity, and this additive is made up of natural Chinese medicinal herb, be of high nutritive value, compatibility science, safety, nutrition, toxic and side effect are little, and this additive can effectively be prevented and treated porcine respiratory disease on the one hand, prevention and result for the treatment of are good, instant effect, and no drug residue, do not produce drug resistance, preparation method is simple to operation simultaneously, constant product quality; This additive can strengthen the immunity of pig on the other hand, reduces the pig incidence of disease, reduces feeding cost, increases raise benefit, has avoided use chemical synthesis additive (as antibiotic etc.) simultaneously.This additive is conducive to promote feed and the healthy and orderly development of livestock, and human health is had to positive effect, belongs to the feed addictive of safe green.
The specific embodiment
The present embodiment is implemented under take technical scheme of the present invention as prerequisite, has provided detailed embodiment and process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
A kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity, every 100 parts are mixed by weight by following raw material: 10 parts, capsule of weeping forsythia powder, 8 parts of mixing polysaccharides of traditional Chinese medicines, 2 parts of leaf of Flos Lonicerae extract, 2 parts, radix bupleuri powder, 3 parts of astragalus membranaceus powders, 2 parts of licorice powders, 2 parts, Radix Isatidis powder, 1 part of Herba Menthae powder, 1 part of codonopsis pilosula powder, 2 parts of rhizoma atractylodis, 1 part of the fruit of glossy privet, all the other are carrier.
The preparation method of described capsule of weeping forsythia powder: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and 1:5 adds deionized water by solid-liquid ratio, then add 1 mixed enzyme, maintain 40 ℃, keep stirring 1h, spraying dry, pulverize 60 mesh sieves and obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 2:1:1 in mass ratio.
The preparation method of described mixing polysaccharides of traditional Chinese medicine: by selected matrimony vine, aloe and ox paint, pulverized respectively 40 mesh sieves, in mass ratio matrimony vine: aloe: ox paint=3:2:1 mixes, add 12 times of deionized waters, ultrasonic extraction 30min, extracting temperature is 60 ℃, ultrasonic power 120W, vacuum filtration; Filter residue adds 6 times of deionized waters, ultrasonic extraction 20min, and extracting temperature is 60 ℃, ultrasonic power 120W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to ethanol solubility 76%, put into standing 2h under 6 ℃ of conditions; Get precipitated liquid freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine.
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 2h by solid-liquid ratio 1:5, extract temperature 60 C, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 35 ℃;
(2) toward the ethanol that adds 68% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:8, ultrasonic extraction 30 minutes, 80 watts of temperature 70 C, power, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merges twice filtrate, is evaporated to 1/7 of original volume;
(3) extract obtaining in (2) is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 2h, wash 2BV with water, flow velocity is 1BV/h, then use 60% ethanol elution 5BV, flow velocity is 1BV/h, and the spraying of collection ethanol eluate dry, pulverize 60 mesh sieves and obtains leaf of Flos Lonicerae extract;
Described radix bupleuri powder, preparation method thereof: radix bupleuri was pulverized to 60 mesh sieves;
Described astragalus membranaceus powder preparation method: the Radix Astragali was pulverized to 60 mesh sieves;
Described licorice powder preparation method: Radix Glycyrrhizae was pulverized to 60 mesh sieves;
Described Radix Isatidis powder, preparation method thereof: Radix Isatidis was pulverized to 60 mesh sieves;
Described Herba Menthae powder preparation method: peppermint was pulverized to 60 mesh sieves;
Described codonopsis pilosula powder preparation method: Radix Codonopsis was pulverized to 80 mesh sieves;
Described rhizoma atractylodis powder, preparation method thereof: rhizoma atractylodis were pulverized to 40 mesh sieves;
Described fruit of glossy privet powder, preparation method thereof: the fruit of glossy privet was pulverized to 40 mesh sieves;
Described carrier is the 2-3:1:4-5 mixing in mass ratio of defatted rice bran, zeolite powder and maize cob meal, pulverizes 40 mesh sieves;
In pig feed per ton, add 1000 grams of these additives.
Embodiment 2
A kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity, every 100 parts are mixed by weight by following raw material: 13 parts, capsule of weeping forsythia powder, 11 parts of mixing polysaccharides of traditional Chinese medicines, 3 parts of leaf of Flos Lonicerae extract, 3 parts, radix bupleuri powder, 4 parts of astragalus membranaceus powders, 3 parts of licorice powders, 2 parts, Radix Isatidis powder, 1 part of Herba Menthae powder, 2 parts of codonopsis pilosula powder, 2 parts of rhizoma atractylodis, 1 part of the fruit of glossy privet, all the other are carrier.
The preparation method of described capsule of weeping forsythia powder: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and 1:7 adds deionized water by solid-liquid ratio, then add 1.2% mixed enzyme, maintain 56 ℃, keep stirring 1.2h, spraying dry, pulverize 60 mesh sieves and obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 3:1:2 in mass ratio.
The preparation method of described mixing polysaccharides of traditional Chinese medicine: by selected matrimony vine, aloe and ox paint, pulverized respectively 40 mesh sieves, in mass ratio matrimony vine: aloe: ox paint=5:3:1, add 14 times of deionized waters, ultrasonic extraction 35min, extracting temperature is 74 ℃, ultrasonic power 130W, vacuum filtration; Filter residue adds 7 times of deionized waters, ultrasonic extraction 25min, and extracting temperature is 74 ℃, ultrasonic power 130W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to ethanol solubility 81%, put into standing 2.5h under 9 ℃ of conditions; Get precipitated liquid freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine.
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 2.5h by solid-liquid ratio 1:7, extract temperature 70 C, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 45 ℃;
(2) toward the ethanol that adds 75% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:12, ultrasonic extraction 40 minutes, 76 ℃ of temperature, 90 watts of power, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merges twice filtrate, is evaporated to 1/6 of original volume;
(3) extract obtaining in (2) is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 2.5h, wash 2BV with water, flow velocity is 1BV/h, then use 68% ethanol elution 5BV, flow velocity is 1BV/h, and the spraying of collection ethanol eluate dry, pulverize 60 mesh sieves and obtains leaf of Flos Lonicerae extract;
Described radix bupleuri powder, preparation method thereof: radix bupleuri was pulverized to 60 mesh sieves;
Described astragalus membranaceus powder preparation method: the Radix Astragali was pulverized to 60 mesh sieves;
Described licorice powder preparation method: Radix Glycyrrhizae was pulverized to 60 mesh sieves;
Described Radix Isatidis powder, preparation method thereof: Radix Isatidis was pulverized to 60 mesh sieves;
Described Herba Menthae powder preparation method: peppermint was pulverized to 60 mesh sieves;
Described codonopsis pilosula powder preparation method: Radix Codonopsis was pulverized to 80 mesh sieves;
Described rhizoma atractylodis powder, preparation method thereof: rhizoma atractylodis were pulverized to 40 mesh sieves;
Described fruit of glossy privet powder, preparation method thereof: the fruit of glossy privet was pulverized to 40 mesh sieves;
Described carrier is the 2:1:5 mixing in mass ratio of defatted rice bran, zeolite powder and maize cob meal, pulverizes 40 mesh sieves;
In pig feed per ton, add 1400 grams of these additives.
Embodiment 3
A kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity, every 100 parts are mixed by weight by following raw material: 15 parts, capsule of weeping forsythia powder, 12 parts of mixing polysaccharides of traditional Chinese medicines, 3 parts of leaf of Flos Lonicerae extract, 4 parts, radix bupleuri powder, 4 parts of astragalus membranaceus powders, 4 parts of licorice powders, 3 parts, Radix Isatidis powder, 2 parts of Herba Menthae powders, 3 parts of codonopsis pilosula powder, 3 parts of rhizoma atractylodis, 2 parts of the fruit of glossy privets, all the other are carrier.
The preparation method of described capsule of weeping forsythia powder: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and 1:8 adds deionized water by solid-liquid ratio, then add 1.5% mixed enzyme, maintain 60 ℃, keep stirring 1.5h, spraying dry, pulverize 60 mesh sieves, obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 3:1:3 in mass ratio.
The preparation method of described mixing polysaccharides of traditional Chinese medicine: by selected matrimony vine, aloe and ox paint, pulverized respectively 40 mesh sieves, in mass ratio matrimony vine: aloe: ox paint=5:3:1 mixes, add 18 times of deionized waters, ultrasonic extraction 40min, extracting temperature is 80 ℃, ultrasonic power 140W, vacuum filtration; Filter residue adds 9 times of deionized waters, ultrasonic extraction 30min, and extracting temperature is 80 ℃, ultrasonic power 140W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to ethanol solubility 85%, put into standing 3h under 10 ℃ of conditions; Get precipitated liquid freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine.
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 3h by solid-liquid ratio 1:8, extract 75 ℃ of temperature, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 50 ℃;
(2) toward the ethanol that adds 68-85% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:15, ultrasonic extraction 40 minutes, 80 ℃ of temperature, power 100W, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merges twice filtrate, is evaporated to 1/6 of original volume;
(3) extract obtaining in (2) is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 3h, wash 2BV with water, flow velocity is 1BV/h, then use 72% ethanol elution 5BV, flow velocity is 1BV/h, and the spraying of collection ethanol eluate dry, pulverize 60 mesh sieves and obtains leaf of Flos Lonicerae extract;
Described radix bupleuri powder, preparation method thereof: radix bupleuri was pulverized to 60 mesh sieves;
Described astragalus membranaceus powder preparation method: the Radix Astragali was pulverized to 60 mesh sieves;
Described licorice powder preparation method: Radix Glycyrrhizae was pulverized to 60 mesh sieves;
Described Radix Isatidis powder, preparation method thereof: Radix Isatidis was pulverized to 60 mesh sieves;
Described Herba Menthae powder preparation method: peppermint was pulverized to 60 mesh sieves;
Described codonopsis pilosula powder preparation method: Radix Codonopsis was pulverized to 80 mesh sieves;
Described rhizoma atractylodis powder, preparation method thereof: rhizoma atractylodis were pulverized to 40 mesh sieves;
Described fruit of glossy privet powder, preparation method thereof: the fruit of glossy privet was pulverized to 40 mesh sieves;
Described carrier is the 3:1:5 mixing in mass ratio of defatted rice bran, zeolite powder and maize cob meal, pulverizes 40 mesh sieves;
In pig feed per ton, add 1600 grams of these additives.
Test example 1
Test method: select the subordinate of Jia Feng feed corporation,Ltd pig farm, Guangnan (Zhanjiang), select each 100 of sodium selenite that age in days, body weight are close and growing and fattening pigs, all be divided at random 2 groups (test group and control groups), test group daily ration interpolation per ton 1400g embodiment 2 make invention product, control group does not add product of the present invention; Feed continuously 60 days; Test pig is carried out to daily observation and detection.
Compared with control group, use invention feed addictive can obtain following effect:
(1) the breathing problem incidence of disease of test group piglet reduces more than 90% than contrast pig;
(2) test group piglet feedstuff-meat ratio is 1.31, and control group 1.48 has significantly reduced feedstuff-meat ratio;
(3) test group growing and fattening pigs have increased more than 10% than the weight average of control group;
(4) hair color of test pig is carried out to sensory evaluation scores, test group scoring reaches 8.8 points, and control group is 6.3 points;
(5) the test group influenza incidence of disease reduces more than 75% than control group;
Conclusion: product of the present invention can effectively prevent the incidence of disease of porcine respiratory disease, can strengthen the immunity of pig simultaneously, reduces the incidence of disease of pig, promotes the growth of pig and reduces feedstuff-meat ratio.
Test example 2:
Select and suffer from 30 of breathing problem piglet, be equally divided at random 2 groups, the wherein test group feed that contains additive prepared by embodiment 2 of feeding, control group adopts conventional western medicine; Test pig free choice feeding and drinking-water, observe and record rehabilitation situation and the mental status of pig, totally 30 days experimental period in experimental period every day.When off-test, weigh, and ramming material.Observe each processed group state of mind, calculate daily gain, feedstuff-meat ratio (feed intake/weightening finish) and rehabilitation rate.
Result of the test shows that effect and the Western medicine of product of the present invention treatment porcine respiratory disease is suitable, but daily gain is apparently higher than control group, and feedstuff-meat ratio significantly reduces, and is conducive to reduce feeding cost, increase culture benefit.
This product is green product, belongs to green feed field, can effectively prevent and treat breathing problem and immunity is done in enhancing, can substitute or the use of part substitute antibiotics in feed, and feed and cultivation industry are had to active influence, has broad market prospects.
Claims (4)
1. the pig feed additive effectively preventing and treating breathing problem and strengthen immunity, it is characterized in that every 100 parts are mixed by following raw materials by weight portion: capsule of weeping forsythia powder 10-15 part, mixing polysaccharides of traditional Chinese medicine 8-12 part, leaf of Flos Lonicerae extract 2-3 part, radix bupleuri powder 2-4 part, astragalus membranaceus powder 3-4 part, licorice powder 2-4 part, Radix Isatidis powder 2-3 part, Herba Menthae powder 1-2 part, codonopsis pilosula powder 1-3 part, rhizoma atractylodis 2-3 part, fruit of glossy privet 1-2 part, all the other are carrier, carrier be defatted rice bran, zeolite powder and maize cob meal in mass ratio 2-3:1:4-5 mix;
The preparation method of described capsule of weeping forsythia powder is: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and by solid-liquid ratio, 1:5-8 adds deionized water, then adds the mixed enzyme of 1-1.5%, maintains 40-60 ℃, keeps stirring 1-1.5h, and spraying dry, pulverize 60 mesh sieves, obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 2-3:1:1-3 in mass ratio;
The preparation method of described mixing polysaccharides of traditional Chinese medicine is: by selected matrimony vine, aloe and the root of bidentate achyranthes, pulverized respectively 40 mesh sieves, matrimony vine in mass ratio: aloe: the root of bidentate achyranthes=3-5:2-3:1 mixes, add 12-18 times of deionized water, ultrasonic extraction 30-40min, extraction temperature is 60-80 ℃, ultrasonic power 120-140W, vacuum filtration; Filter residue adds 6-9 times of deionized water, ultrasonic extraction 20-30min, and extraction temperature is 60-80 ℃, ultrasonic power 120-140W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to concentration of alcohol 76-85%, put into standing 2-3h under 6-10 ℃ of condition; Get precipitation freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine;
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 2-3h by solid-liquid ratio 1:5-8, extract temperature 60-75 ℃, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 35-50 ℃;
(2) toward the ethanol that adds 68-85% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:8-15, ultrasonic extraction 30-40 minute, temperature 70-80 ℃, power 80-100 watt, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merge filtrate twice, be evaporated to the 1/6-1/7 of original volume;
(3) extract obtaining in (2) after concentrating is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 2-3h, wash 2BV with water, flow velocity is 1BV/h, then use the ethanol elution 5BV of 60-72%, flow velocity is 1BV/h, collects ethanol eluate spraying and is dried, pulverize 60 mesh sieves, obtained leaf of Flos Lonicerae extract.
2. a kind ofly according to claim 1 effectively prevent and treat breathing problem and strengthen the pig feed additive of immunity, it is characterized in that every 100 parts are mixed by following raw materials by weight portion: 13 parts, capsule of weeping forsythia powder, 11 parts of mixing polysaccharides of traditional Chinese medicines, 3 parts of leaf of Flos Lonicerae extract, 3 parts, radix bupleuri powder, 4 parts of astragalus membranaceus powders, 3 parts of licorice powders, 2 parts, Radix Isatidis powder, 1 part of Herba Menthae powder, 2 parts of codonopsis pilosula powder, 2 parts of rhizoma atractylodis, 1 part of the fruit of glossy privet, all the other are carrier, carrier be defatted rice bran, zeolite powder and maize cob meal in mass ratio 2:1:5 mix;
The preparation method of described capsule of weeping forsythia powder: the capsule of weeping forsythia was pulverized to 40 mesh sieves, and 1:7 adds deionized water by solid-liquid ratio, then add 1.2% mixed enzyme, maintain 56 ℃, keep stirring 1.2h, spraying dry, pulverize 60 mesh sieves, obtained capsule of weeping forsythia powder; Mixed enzyme is pectase, zytase and cellulase 3:1:2 in mass ratio;
The preparation method of described mixing polysaccharides of traditional Chinese medicine: by selected matrimony vine, aloe and the root of bidentate achyranthes, pulverized respectively 40 mesh sieves, in mass ratio matrimony vine: aloe: the root of bidentate achyranthes=5:3:1, add 14 times of deionized waters, ultrasonic extraction 35min, extracting temperature is 74 ℃, ultrasonic power 130W, vacuum filtration; Filter residue adds 7 times of deionized waters, ultrasonic extraction 25min, and extracting temperature is 74 ℃, ultrasonic power 130W, vacuum filtration; Merge filtrate twice, centrifugal 5min, rotating speed is 6000r/min; Get supernatant, add absolute ethyl alcohol, to concentration of alcohol 81%, put into standing 2.5h under 9 ℃ of conditions; Get precipitation freeze drying, pulverized 60 mesh sieves and obtain mixing polysaccharides of traditional Chinese medicine;
The preparation method of described leaf of Flos Lonicerae extract is made up of following steps:
(1) selected honeysuckle-leaf is pulverized, crossed 30 mesh sieves, add benzinum refluxing extraction 2.5h by solid-liquid ratio 1:7, extract temperature 70 C, extracted final vacuum suction filtration, filtrate decompression concentration and recovery benzinum, filter residue adopts forced air drying to obtain degreasing honeysuckle-leaf powder, and baking temperature is 45 ℃;
(2) toward the ethanol that adds 75% in degreasing honeysuckle-leaf powder by solid-liquid ratio 1:12, ultrasonic extraction 40 minutes, 76 ℃ of temperature, 90 watts of power, extract final vacuum suction filtration, filter residue extracts 2 times with identical condition again, merges twice filtrate, is evaporated to 1/6 of original volume;
(3) extract obtaining in (2) after concentrating is evenly injected to the chromatographic column that HPD600 macroreticular resin is housed, leave standstill 2.5h, wash 2BV with water, flow velocity is 1BV/h, then use 68% ethanol elution 5BV, flow velocity is 1BV/h, collects ethanol eluate spraying and is dried, pulverize 60 mesh sieves, obtained leaf of Flos Lonicerae extract.
3. according to a kind of pig feed additive of effectively preventing and treating breathing problem and strengthening immunity described in claim 1-2 any one, the addition in pig feed is 1000-1600g/ ton.
4. a kind ofly according to claim 3 effectively prevent and treat breathing problem and strengthen the pig feed additive of immunity, the addition in pig feed is 1400g/ ton.
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| CN104273395A (en) * | 2014-10-28 | 2015-01-14 | 广东双胞胎饲料有限公司 | Pig biological feed additive capable of effectively enhancing immunity |
| CN105055859B (en) * | 2015-08-20 | 2018-12-07 | 青岛中农华商生物工程有限公司 | A kind of method of preparation and use preventing and treating livestock and birds respiratory disease complexing agent |
| CN105341417A (en) * | 2015-11-30 | 2016-02-24 | 山东绿都安特动物药业有限公司 | Feed additive for weaned pigs, capable of controlling respiratory diseases and improving immunity |
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| CN115633735A (en) * | 2022-09-27 | 2023-01-24 | 翁源县新南都饲料科技有限公司 | Plant extract feed additive for preventing and treating porcine respiratory diseases and enhancing immunity |
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Effective date of registration: 20151228 Address after: 528100 C District, southwest science and Technology Industrial Park, Sanshui District, Guangdong, Foshan, China Patentee after: GUANGDONG TWINS FEED CO., LTD. Address before: 524045 Guangdong Province, Zhanjiang city Chikan North Road No. 2 Patentee before: Guangnan (Zhanjiang) Jiafeng Feed Co.,Ltd. |