CN102743508A - Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof - Google Patents
Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof Download PDFInfo
- Publication number
- CN102743508A CN102743508A CN2012102117881A CN201210211788A CN102743508A CN 102743508 A CN102743508 A CN 102743508A CN 2012102117881 A CN2012102117881 A CN 2012102117881A CN 201210211788 A CN201210211788 A CN 201210211788A CN 102743508 A CN102743508 A CN 102743508A
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- radix
- avian infectious
- isatidis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a compound propolis composition for treating avian infectious laryngotracheitis and a preparation method thereof. The compound propolis composition is prepared by mixing 15 to 35 parts by weight of propolis, 25 to 55 parts by weight of gypsum, 15 to 35 parts by weight of folium isatidis, 10 to 35 parts by weight of isatis root, 15 to 35 parts by weight of honeysuckle, 10 to 35 parts by weight of baical skullcap root, 10 to 35 parts by weight of orange fruit, 15 to 35 parts by weight of liquorice, 15 to 35 parts by weight of tatarian aster root, and 10 to 30 parts by weight of borneol. The compound propolis composition has a reasonable formula, can be prepared by simple processes, has no toxic or side effects, does not produce pollution and drug residues, does not cause drug resistance, is crushed into superfine powder, and has high bioavailability and obvious treatment effects. In clinical, the compound propolis composition has special effects of treatment on avian infectious laryngotracheitis.
Description
Technical field
The present invention relates to treat bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof, belong to the animal field of medicaments, particularly a kind of bronchitic compound bee-glue composition of the avian infectious larynx of treatment and preparation method thereof that is specifically designed to.
Background technology
Avian infectious larynx bronchitis is a kind of acute, the contact upper respiratory infectious disease that is caused by avian infectious larynx bronchitis virus.The chicken of various ages and kind all can infect, and it is characterized in that dyspnea, cough and expectoration contain the exudate of blood sample.Visible throat, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn when cuing open inspection.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can take place throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is a herpesvirus, and virus can be survived more than 1 year under dry environment.Under cryogenic conditions, the time-to-live is long.This disease almost spreads all over all countries of raising chickens of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And the various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.
Therefore researching and developing a kind of bronchitic drug residue free of avian infectious larynx, generations that have no drug resistance, the significant specific medicament of clinical effectiveness of treating is one of this field scientific research technical staff urgency new problem to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the bronchitic compound bee-glue composition of the avian infectious larynx of effective treatment of drug residue and preparation method thereof.
For realizing above-mentioned purpose; The embodiment that the present invention adopted is following: the bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment, by following component by weight mixed preparing form: propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part, Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part.
Said various component optimum ratio amount is: 25 parts of propolis, 50 parts in Gypsum Fibrosum, 25 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 25 parts of Flos Loniceraes, 25 parts of Radix Scutellariaes, 20 parts of Fructus Aurantiis, 25 parts in Radix Glycyrrhizae, 25 parts of Radix Asteriss, 20 parts of Borneolum Syntheticums.
A kind of method for preparing of treating the bronchitic compound bee-glue composition of avian infectious larynx, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part by weight, mix 5-10 minute to even;
(3) take by weighing Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Gypsum Fibrosum: sweet, hot, cold, attach to the lung and stomach meridians, have the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, hyperpyrexia are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Fructus Aurantii: bitter, hot, acid, warm, return stomach, spleen channel, the function that have promoting the circulation of QI to alleviate the stagnation in middle-JIAO, reduce phlegm, helps digestion; Cure mainly that dyspepsia does not disappear, tripe expands, feces is dry, hang down and take off disease, the expectorant vapour lock etc. that stagnates.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Radix Asteris: bitter, hot, warm, return lung meridian, have the function of nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm; Cure mainly cough, abundant expectoration dyspnea with rapid respiration etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Borneolum Syntheticum: hot, bitter, cold, GUIXIN, spleen, lung meridian have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to the bronchitic pathogenic microorganism of avian infectious larynx and clinical symptoms and pathological change, bring into play the effect of treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, can also can drink water the curative effect highly significant by spice.The present invention is according to Chinese veterinarian's traditional theory; Optimize this ten flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; To treating avian infectious larynx bronchitis specially good effect is arranged; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, 250 parts in Gypsum Fibrosum, 250 parts of Folium Isatidiss, 100 parts of Radix Isatidis, 150 parts of Flos Loniceraes by weight, mix 5-10 minute to even;
(3) take by weighing 100 parts of Radix Scutellariaes, 100 parts of Fructus Aurantiis, 150 parts in Radix Glycyrrhizae, 150 parts of Radix Asteriss, 100 parts of Borneolum Syntheticums by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, 400 parts in Gypsum Fibrosum, 250 parts of Folium Isatidiss, 150 parts of Radix Isatidis, 250 parts of Flos Loniceraes by weight, mix 5-10 minute to even;
(3) take by weighing 150 parts of Radix Scutellariaes, 150 parts of Fructus Aurantiis, 250 parts in Radix Glycyrrhizae, 250 parts of Radix Asteriss, 200 parts of Borneolum Syntheticums by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 350 parts of propolis, 550 parts in Gypsum Fibrosum, 350 parts of Folium Isatidiss, 350 parts of Radix Isatidis, 350 parts of Flos Loniceraes by weight, mix 5-10 minute to even;
(3) take by weighing 350 parts of Radix Scutellariaes, 350 parts of Fructus Aurantiis, 350 parts in Radix Glycyrrhizae, 350 parts of Radix Asteriss, 300 parts of Borneolum Syntheticums by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects for use 22 ages in days, body weight at 1.0kg-1.5kg, and laboratory is diagnosed as the bronchitic ill broiler of avian infectious larynx.Ill chicken is isolated raising separately, the complete feed of feeding, and be divided into 3 groups at random, and 60 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Chinese medicine composition group of the present invention is with the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds or the 450kg that drinks water, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table the present invention and other medicines are treated the bronchitic situation contrast of avian infectious larynx:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 25.0 | 35.0 | 40.0 |
| II | The HOUYANJING SAN group | 8.3 | 76.7 | 15.0 |
| III | Chinese medicine composition group of the present invention | 6.7 | 86.6 | 6.7 |
The result is through statistical analysis in this clinical experiment, and present composition treatment group is being compared difference extremely significantly (P＜0.01) with the HOUYANJING SAN group aspect the cure rate.
Safety testing:
Choose 60 of 20 age in days healthy AA broiler; According to 10 times of spices of the embodiment of the invention 1 made Chinese medicine composition RD or drank water 5 days; During the medication; Healthy chicken has no bad or Deviant Behavior performance, and the drinking-water of searching for food is normal, and it is not remarkable that weight increase and blank group (being not administration of health group) are compared difference.
Above-mentionedly this is treated the detailed description that bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof carries out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. treatment avian infectious larynx bronchitic compound bee-glue composition, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part, Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part.
2. the bronchitic compound bee-glue composition of the avian infectious larynx of treatment according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 50 parts in Gypsum Fibrosum, 25 parts of Folium Isatidiss, 25 parts of Radix Isatidis, 25 parts of Flos Loniceraes, 25 parts of Radix Scutellariaes, 20 parts of Fructus Aurantiis, 25 parts in Radix Glycyrrhizae, 25 parts of Radix Asteriss, 20 parts of Borneolum Syntheticums.
3. the method for preparing of the bronchitic compound bee-glue composition of the avian infectious larynx of treatment according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part by weight, mix 5-10 minute to even;
(3) take by weighing Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210211788.1A CN102743508B (en) | 2012-06-26 | 2012-06-26 | Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210211788.1A CN102743508B (en) | 2012-06-26 | 2012-06-26 | Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102743508A true CN102743508A (en) | 2012-10-24 |
| CN102743508B CN102743508B (en) | 2015-04-22 |
Family
ID=47024237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210211788.1A Active CN102743508B (en) | 2012-06-26 | 2012-06-26 | Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102743508B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973668A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Compound pure traditional Chinese medicine composition for treating avian infectious laryngotracheitis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096206A (en) * | 1993-06-10 | 1994-12-14 | 寿光县岔河乡畜牧兽医工作站 | Kewenning for curing pestilence |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102357154A (en) * | 2011-11-01 | 2012-02-22 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis and preparation method thereof |
| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3058261B2 (en) * | 1997-05-28 | 2000-07-04 | 日本電気株式会社 | CDMA handoff system, mobile communication cellular system using the same, and base station thereof |
-
2012
- 2012-06-26 CN CN201210211788.1A patent/CN102743508B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096206A (en) * | 1993-06-10 | 1994-12-14 | 寿光县岔河乡畜牧兽医工作站 | Kewenning for curing pestilence |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102357154A (en) * | 2011-11-01 | 2012-02-22 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis and preparation method thereof |
| CN102579779A (en) * | 2012-03-22 | 2012-07-18 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Non-Patent Citations (1)
| Title |
|---|
| 岳治权: "中药防治鸡传染性喉气管炎及支气管炎现状", 《动物医学进展》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973668A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Compound pure traditional Chinese medicine composition for treating avian infectious laryngotracheitis and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102743508B (en) | 2015-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102961636B (en) | Pure traditional Chinese medicine composition for treating poultry infectious bursal disease and preparation method thereof | |
| CN102784219B (en) | Compound pure Chinese medicine composition for treating bovine ephemeral fever and preparation method of same | |
| CN102727770B (en) | Pure traditional Chinese medicine composition used for treating swine influenza, and preparation method thereof | |
| CN102784243A (en) | Pure Chinese medicine composition for treating cattle flu and preparation method of same | |
| CN102727848B (en) | Pure traditional Chinese medicine composition used for treating poultry infectious bursal disease, and preparation method thereof | |
| CN102727693B (en) | Compound propolis composition used for treating swine toxoplasmosis, and preparation method thereof | |
| CN102488881B (en) | Compound propolis composition for promoting pig growth and fattening as well as its preparation method | |
| CN103599362A (en) | Traditional Chinese medicine composition for treating swine enzootic pneumonia and preparation method thereof | |
| CN102743508B (en) | Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof | |
| CN102743669B (en) | Compound propolis composition for treating swine enzootic pneumonia | |
| CN103479831B (en) | Pure Chinese medicine composition for the treatment of chicken infectious anemia and preparation method thereof | |
| CN102670804B (en) | Compound propolis composition for treating poultry dysentery and preparation method thereof | |
| CN102961487B (en) | Compound combination made from pure traditional Chinese medicines and used for treating henpox and preparation method of combination | |
| CN102784371B (en) | Pure traditional medicine composition for treating swine flu and preparation method of pure traditional medicine composition | |
| CN102727694B (en) | Compound propolis composition used for treating broiler ascites syndrome, and preparation method thereof | |
| CN102727669B (en) | Compound propolis composition used for treating swine erysipelas, and preparation method thereof | |
| CN103599452A (en) | Traditional Chinese medicine composition for treating mycoplasma suis and preparation method thereof | |
| CN103585606B (en) | Bronchitic Chinese medicine composition for the treatment of chicken infectivity throat and preparation method thereof | |
| CN102641473B (en) | Compound propolis composition for curing chicken infectivity coryza and preparation method thereof | |
| CN102961568B (en) | Compound bee-glue composition for the treatment of unknown high fever of pigs and preparation method thereof | |
| CN102670761B (en) | Pure traditional Chinese medicine composition for treating infectious bursal disease of poultry and preparation method thereof | |
| CN103611067B (en) | Compound traditional Chinese medicine composite for the treatment of infectious bronchitis of chicken and preparation method thereof | |
| CN103041047A (en) | Compound propolis composition for treating ox influenza and preparation method thereof | |
| CN102961516B (en) | Pure Chinese medicine composition for the treatment of duck viral hepatitis and preparation method thereof | |
| CN102370739B (en) | Compound propolis composition for treating whitecomb of chickens and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190109 Address after: 471000 No. 58 Dig Ding Road, Koudian Village, Koudian Town, Yibin District, Luoyang City, Henan Province Patentee after: Luoyang Tianmeng Biotechnology Co., Ltd. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |
|
| TR01 | Transfer of patent right |