CN104306441A - Traditional Chinese medicine oral solution for treating swine influenza and preparation method thereof - Google Patents
Traditional Chinese medicine oral solution for treating swine influenza and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention relates to a traditional Chinese medicine oral solution for treating swine influenza. The oral solution is prepared from the following components in parts by weight: 10-20 parts of radix bupleuri, 5-20 parts of scutellaria baicalensis, 5-20 parts of radix isatidis, 5-15 parts of dandelion, 10-30 parts of folium isatidis, 5-20 parts of licorice root and 5-10 parts of gypsum. The traditional Chinese medicine oral solution has the effects of clearing heat, removing toxicity, diminishing inflammation and resisting viruses, has small toxic and side effect, cannot easily generate drug resistance, and has the advantages of high bioavailability and no drug residue.
Description
Technical field
The invention belongs to field of veterinary, especially a kind of Chinese medicine oral liquid for the treatment of swine influenza and preparation method thereof.
Background technology
Swine influenza is that the one of pig is acute, infectiousness respiratory illness.It is characterized by burst, cough, dyspnea, generate heat and lapse to rapidly.Swine flue is the respiratory system disease that pig body endogenous cause of ill virus causes.Swine flue is caused by influenza A virus (influenza A), usually breaks out between pig, and infectiousness is very high but usually can not cause death.Autumn and winter belongs to the high-incidence season, but the whole year can propagate.One of swine flue is recognized as influenza virus C (C type influenza virus) more, or the subspecies of influenza A virus.This virus can cause Influenza Outbreak in swinery.
The sickness rate of this disease is high, and incubation period is 2 ~ 7 days, the course of disease about 1 week.Sick pig their early stage generates heat suddenly, lassitude, loss of appetite or absolutely useless, and normal accumbency together, is reluctant activity, and dyspnea, fierce cough, eye nose flows out mucus.If in period of disease treatment not in time, then easy concurrent bronchitis, pneumonia and pleuritis etc., increase the case fatality rate of pig.Sick temperature of pig body raises and reaches 40 DEG C ~ 41.5 DEG C, and spirit is depressed, loss of appetite or do not eat, myalgia, is reluctant to stand, and eye and nose have viscous liquid to flow out, conjunctival congestion, indivedual sick pig dyspnea, breathes, cough, in ventral breathing, there is sitting position of dog gesture, disease pig whoop can be heard at night, indivedual sick pig arthralgia, especially the morbidity of the growth of livestock good pig is more serious.Cuing open inspection visible larynx, trachea and bronchus is full of containing alveolate mucus, and mucosa is congested, swelling, time and be mixed with blood, interstitial lung is broadening, lymphadenectasis, congested, splenomegaly, gastrointestinal mucosa has mucositis hemorrhagic inflammation, the liquid of splanchnocoel, pericardial cavity accumulation cellulose-containing mass.
At present, swine influenza causes damage comparatively large to pig industry clinically, and the antiviral agents of Western medicine mostly is violated medicine, cannot apply clinically.In addition, the effect of chemical medicine is unstable, easily affects treatment time adversely.Because the variability of virus is comparatively strong, the preparation of vaccine is difficult to the variation of catching up with virus.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine oral liquid for the treatment of swine influenza, this oral liquid has heat clearing away, removing toxic substances, antiinflammatory, antiviral effect, and toxic and side effects is little, not easily produces drug resistance, and bioavailability is high, drug residue free.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine oral liquid of swine influenza.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine oral liquid for swine influenza, component and the ratio of weight and number thereof of its oral liquid are respectively: Radix Bupleuri 10-20 part; Radix Scutellariae 5-20 part; Radix Isatidis 5-20 part; Herba Taraxaci 5-15 part; Folium Isatidis 10-30 part; Radix Glycyrrhizae 5-20 part; Gypsum Fibrosum 5-10 part.
And component and the optimum ratio of weight and number thereof of this oral liquid are respectively: Radix Bupleuri 15 parts; Radix Scutellariae 13 parts; Radix Isatidis 12 parts; Herba Taraxaci 10 parts; Folium Isatidis 20 parts; 16 parts, Radix Glycyrrhizae; Gypsum Fibrosum 7 parts.
Treat a preparation method for the Chinese medicine oral liquid of swine influenza, the steps include:
(1) take Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum respectively by weight ratio, roguing, weigh after add respectively in super micron mill machine and pulverize;
(2) decoct three times after the Radix Bupleuri after pulverizing in step (1), Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum being added 3.5 times of water soaking 5-8 hours, each about 30-60min, filtration obtains filtrate A, and collects recrement, for subsequent use;
(3) recrement after step (2) being filtered adds 3-8 times amount clear water, boils rear 20-30min at a simmer, filters and obtains liquor B, for subsequent use;
(4) merging filtrate A and liquor B, filter, being concentrated into relative density is 1.01-1.03, adds 95% ethanol, makes alcohol content reach 40%, stirs evenly, and leaves standstill 24 hours, filters, and reclaims ethanol to without alcohol taste, adds suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(5) in the supernatant of step (4) gained, add ethanol and the 4-6% tween 80 of 35-40%, stir evenly, filter, subpackage, sterilizing, the Chinese medicine oral liquid finished product of swine influenza must be treated.
Advantage of the present invention and beneficial effect are:
The Radix Bupleuri contained in the Chinese medicine oral liquid of 1, this treatment swine influenza, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, the Chinese medicinal ingredients such as Radix Glycyrrhizae and Gypsum Fibrosum, there is good preventive and therapeutic effect, antivirus action successful to the respiratory tract disease that antibacterial and virus cause.
2, the present invention contains the 7 taste Chinese medicines such as Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum, pulverizes, be conducive to the raising of herbal medicine efficacy through super micron mill.By the compatibility of Chinese medicinal formulae, greatly can improve the curative effect of said composition, improve body disease-resistant power.
3, the Chinese medicine oral liquid of this treatment swine influenza have taking dose little, delicious, absorb fast, prove effective rapidly, steady quality, be easy to carry, be easy to the advantages such as preservation.
4, the present invention has heat clearing away, removing toxic substances, antiinflammatory, cough-relieving, antiviral effect, have no side effect little, not easily produce drug resistance, bioavailability is high, drug residue free, meeting safe veterinary drug, ensure the requirement of animal-derived food safety, is a kind of Chinese medicine oral liquid of ideal treatment swine influenza.
Detailed description of the invention
The present invention is described in further detail by following examples.It should be noted that: following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
Treat a Chinese medicine oral liquid for swine influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Bupleuri 100g; Radix Scutellariae 100g; Radix Isatidis 150g; Herba Taraxaci 100g; Folium Isatidis 100g; Radix Glycyrrhizae 100g; Gypsum Fibrosum 50g.
Treat a preparation method for the Chinese medicine oral liquid of swine influenza, its step is as follows:
(1) take Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum respectively by weight ratio, roguing, weigh after add respectively in super micron mill machine and pulverize;
(2) decoct three times after the Radix Bupleuri after pulverizing in step (1), Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum being added 3.5 times of water soaking 5-8 hours, each about 30-60min, filtration obtains filtrate A, and collects recrement, for subsequent use;
(3) recrement after step (2) being filtered adds 3-8 times amount clear water, boils rear 20-30min at a simmer, filters and obtains liquor B, for subsequent use;
(4) merging filtrate A and liquor B, filter, being concentrated into relative density is 1.01-1.03, adds 95% ethanol, makes alcohol content reach 40%, stirs evenly, and leaves standstill 24 hours, filters, and reclaims ethanol to without alcohol taste, adds suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(5) in the supernatant of step (4) gained, add ethanol and the 4-6% tween 80 of 35-40%, stir evenly, filter, subpackage, sterilizing, the Chinese medicine oral liquid finished product of swine influenza must be treated.
Embodiment 2
Treat a Chinese medicine oral liquid for swine influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Bupleuri 200g; Radix Scutellariae 300g; Radix Isatidis 200g; Herba Taraxaci 200g; Folium Isatidis 100g; Radix Glycyrrhizae 80g; Gypsum Fibrosum 100g.
The step of its preparation method is with embodiment 1.
Embodiment 3
Treat a Chinese medicine oral liquid for swine influenza, component and the weight thereof of its Chinese medicine oral liquid are respectively: Radix Bupleuri 150g; Radix Scutellariae 250g; Radix Isatidis 200g; Herba Taraxaci 175g; Folium Isatidis 250g; Radix Glycyrrhizae 100g; Gypsum Fibrosum 100g.
The step of its preparation method is with embodiment 1.
Clinical practice
In order to verify the clinical therapeutic efficacy of the present invention to swine influenza, in the cultivation factory of certain infected pigs influenza virus of Dezhou City Shandong Province, carry out the clinical trial of the swine influenza that the present invention causes pig natural infection swine influenza virus.The present invention is divided into basic, normal, high three dosage to carry out grouping administration to animal by test, compares, thus evaluate therapeutic effect of the present invention and optimum amount with blank group.
1, materials and methods
1.1 experimental animal
There is the pig farm of swine influenza in Dezhou City Shandong Province, filters out ill pig 50 for subsequent use.
1.2 trial drug
The present invention is prepared by our company.
1.3 experimental animal groupings and process
The sick pig of abiogenous swine influenza is divided into 4 groups at random, often organizes 10.
In addition, 10 health pig of not falling ill are filtered out as normal healthy controls group.
1.4 result of the test
To the pig of natural infection swine influenza virus, give the oral liquid of various dose respectively, after mixed drink, by comparing with matched group, the clinical symptoms of morbidity pig obviously alleviates, and case fatality rate declines.Therapeutic effect and the recovery situation of middle dosage group all reach desirable requirement, substantially suitable with normal healthy controls group; The results are shown in following table.
Table 1 observation of curative effect
1.5 interpretation of result
From clinical symptoms, cut open inspection change, case fatality rate, cure rate four aspects analyze, the therapeutic effect of middle dosage group and high dose group is apparently higher than infecting matched group, and consider economic benefit, in final advisory the present invention, dosage carries out therapeutic effect the best.
1.6 conclusion
The present invention is by per kilogram of body weight 2mL administration, and mixed drink, treats the swinery of natural infection swine influenza virus, achieve good therapeutic effect for continuous 5 days.
Claims (3)
1. treat a Chinese medicine oral liquid for swine influenza, it is characterized in that: component and the ratio of weight and number thereof of this oral liquid are respectively: Radix Bupleuri 10-20 part; Radix Scutellariae 5-20 part; Radix Isatidis 5-20 part; Herba Taraxaci 5-15 part; Folium Isatidis 10-30 part; Radix Glycyrrhizae 5-20 part; Gypsum Fibrosum 5-10 part.
2. the Chinese medicine oral liquid for the treatment of swine influenza according to claim 1, is characterized in that: component and the optimum ratio of weight and number thereof of this oral liquid are respectively: Radix Bupleuri 15 parts; Radix Scutellariae 13 parts; Radix Isatidis 12 parts; Herba Taraxaci 10 parts; Folium Isatidis 20 parts; 16 parts, Radix Glycyrrhizae; Gypsum Fibrosum 7 parts.
3. a preparation method for the Chinese medicine oral liquid for the treatment of swine influenza as claimed in claim 1, is characterized in that: this preparation method step is:
(1) take Radix Bupleuri, Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum respectively by weight ratio, roguing, weigh after add respectively in super micron mill machine and pulverize;
(2) decoct three times after the Radix Bupleuri after pulverizing in step (1), Radix Scutellariae, Radix Isatidis, Herba Taraxaci, Folium Isatidis, Radix Glycyrrhizae and Gypsum Fibrosum being added 3.5 times of water soaking 5-8 hours, each about 30-60min, filtration obtains filtrate A, and collects recrement, for subsequent use;
(3) recrement after step (2) being filtered adds 3-8 times amount clear water, boils rear 20-30min at a simmer, filters and obtains liquor B, for subsequent use;
(4) merging filtrate A and liquor B, filter, being concentrated into relative density is 1.01-1.03, adds 95% ethanol, makes alcohol content reach 40%, stirs evenly, and leaves standstill 24 hours, filters, and reclaims ethanol to without alcohol taste, adds suitable quantity of water, centrifuging and taking supernatant, for subsequent use;
(5) in the supernatant of step (4) gained, add ethanol and the 4-6% tween 80 of 35-40%, stir evenly, filter, subpackage, sterilizing, the Chinese medicine oral liquid finished product of swine influenza must be treated.
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Cited By (2)
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| CN104940338A (en) * | 2015-06-17 | 2015-09-30 | 产俊涛 | Traditional Chinese medicine composition for treating SI (Swine influenza) and application thereof |
| CN105477065A (en) * | 2015-12-16 | 2016-04-13 | 宁风廷 | Method using Chinese herbal medicine to prevent influenza |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940338A (en) * | 2015-06-17 | 2015-09-30 | 产俊涛 | Traditional Chinese medicine composition for treating SI (Swine influenza) and application thereof |
| CN105477065A (en) * | 2015-12-16 | 2016-04-13 | 宁风廷 | Method using Chinese herbal medicine to prevent influenza |
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Application publication date: 20150128 |
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