CN111434348A

CN111434348A - Medicine for treating plague of livestock

Info

Publication number: CN111434348A
Application number: CN201910036113.XA
Authority: CN
Inventors: 特古斯巴乙拉; 包呼格吉乐图
Original assignee: Te Gusibayila
Current assignee: Te Gusibayila
Priority date: 2019-01-15
Filing date: 2019-01-15
Publication date: 2020-07-21

Abstract

The invention provides a traditional Chinese medicine composition for treating livestock plague, which comprises a first component and a second component: the first component comprises the following components in parts by weight: 25 parts of radix glehniae, 5 parts of liquorice, 7.5 parts of bistort rhizome, 14 parts of lacca, 50 parts of elecampane, 25 parts of rubus corchorifolius, 50 parts of radix sophorae flavescentis, 12.5 parts of rhizoma kaempferiae, 25 parts of myrobalan, 15 parts of szechwan chinaberry fruit and 30 parts of gardenia; the second component comprises the following components in parts by weight: 60 parts of dyers woad leaf, 60 parts of isatis root, 60 parts of gypsum, 30 parts of rhubarb and 30 parts of glauber salt. The medicine provided by the invention can effectively treat the plague of livestock, and the example results show that: the effective rate of the medicine prepared by the invention for treating the livestock plague is 90%.

Description

Medicine for treating plague of livestock

Technical Field

The invention belongs to the technical field of veterinary drugs, and particularly relates to a drug for treating pestilence of livestock.

Background

Plague is an infectious disease caused by some strongly pathogenic microorganisms, such as bacteria and viruses. Common plague diseases of livestock comprise foot and mouth disease, highly pathogenic avian influenza, epidemic disease, highly pathogenic blue ear disease, swine fever, newcastle disease, bovine tuberculosis, anthrax, rabies, pseudorabies, melioidis, equine poverty, equine influenza, mad cow disease, scrapie, bluetongue disease, goat/sheep pox, small ruminant epidemic disease, sheep three diseases, swine encephalitis B, porcine parvovirus disease, porcine circovirus disease, swine streptococcosis, African swine fever, canine distemper and the like.

The plague has the characteristics of high infection rate, high propagation speed and large destruction degree, and brings destructive attack to livestock once occurring in a large scale. In recent years, domestic livestock breeding is often plagued by various pestilences, which causes great harm to the breeding. The traditional Chinese herbal medicine powder or decoction is difficult to obtain better curative effect, the western medicine is generally antibiotic medicine, is only effective to bacterial infection and has poor curative effect on viral plague, and meanwhile, if the antibiotic is abused for a long time, the bacteria can generate drug resistance, the curative effect is reduced, and the residue and toxic and side effects of the veterinary medicine in livestock and poultry are increased.

Disclosure of Invention

In view of the above, the invention provides a medicament for treating livestock plague, which can effectively treat the livestock plague.

In order to solve the above problems, the present invention provides the following technical solutions:

The invention provides a traditional Chinese medicine composition for treating livestock plague, which comprises a first component and a second component; the first component comprises the following components in parts by weight: 25 parts of radix glehniae, 5 parts of liquorice, 7.5 parts of bistort rhizome, 14 parts of lacca, 50 parts of elecampane, 25 parts of rubus corchorifolius, 50 parts of radix sophorae flavescentis, 12.5 parts of rhizoma kaempferiae, 25 parts of myrobalan, 15 parts of szechwan chinaberry fruit and 30 parts of gardenia;

The second component comprises the following components in parts by weight:

60 parts of dyers woad leaf, 60 parts of isatis root, 60 parts of gypsum, 30 parts of rhubarb and 30 parts of glauber salt.

Preferably, the dosage of the medicine is 0.75-1 g per 1Kg of body weight of livestock.

Preferably, the dosage form of the medicine is powder.

Preferably, the powder is taken directly or by decocting the first component to obtain a decoction of the first component, and soaking the second component in the decoction of the first component.

Preferably, the method of decocting comprises the steps of:

1) Mixing the first component with water to obtain a total mixture;

2) Decocting the total mixture obtained in the step 1) until boiling, and then decocting for 8-12 min.

preferably, the mass volume ratio of the first component to the water in the step 1) is 1g to 7m L.

Preferably, the soaking time is 13-17 min.

Preferably, the livestock plague comprises livestock foot and mouth disease, highly pathogenic avian influenza, epidemic disease, highly pathogenic porcine reproductive and respiratory syndrome, swine fever, newcastle disease, bovine tuberculosis, anthrax, rabies, pseudorabies, melioidis, equine poverty, equine influenza, mad cow disease, scrapie, bluetongue disease, goat/sheep pox, small ruminant disease, sheep three diseases, swine encephalitis B, swine parvovirus disease, porcine circovirus disease, swine streptococcosis, African swine fever and canine distemper.

The invention provides a traditional Chinese medicine composition for treating livestock plague, which comprises a first component and a second component; the first component comprises the following components in parts by weight: 25 parts of radix glehniae, 5 parts of liquorice, 7.5 parts of bistort rhizome, 14 parts of lacca, 50 parts of elecampane, 25 parts of rubus corchorifolius, 50 parts of radix sophorae flavescentis, 12.5 parts of rhizoma kaempferiae, 25 parts of myrobalan, 15 parts of szechwan chinaberry fruit and 30 parts of gardenia; the second component comprises the following components in parts by weight: 60 parts of dyers woad leaf, 60 parts of isatis root, 60 parts of gypsum, 30 parts of rhubarb and 30 parts of glauber salt. In the invention, the first component in the medicine for preventing and treating the livestock plague takes the lightyellow sophora root and the coastal glehnia root as monarch drugs, the lightyellow sophora root has the effects of clearing heat, inhibiting bacteria, promoting urination and relieving pain, the coastal glehnia root has the effects of clearing blood heat and lung heat, and the lacca is used as an adjuvant drug. The liquorice is matched as an adjuvant drug to relieve cough and eliminate phlegm. Bistort rhizome is an adjuvant drug and has the effects of clearing lung heat and detoxifying so as to achieve the effect of treating pyretic pulmonary disease and various heat type cough and dyspnea. Elecampane, rhizoma kaempferiae, myrobalan, szechwan chinaberry fruit and gardenia are used as ministerial drugs to play the effects of clearing pestilence, relieving exterior syndrome, detoxifying and cooling blood; the Rubus alceaefolius Linnaeus is an adjuvant drug, has effects of relieving exterior syndrome, eliminating Heryi heat, relieving cough and resisting bacteria. In the second component, the radix isatidis is a monarch drug, and the contained syringic acid, anthranilic acid, salicylic acid and the like in the radix isatidis have the function of resisting endotoxin, and have the function of inhibiting hemorrhagic fever with renal syndrome, encephalitis B virus, mumps virus, herpes simplex virus, hepatitis B virus and the like; gypsum and radix et rhizoma Rhei are ministerial drugs, wherein the gypsum can promote macrophage phagocytosis of endogenous pyrogen to generate endogenous pyrogen, and lower body temperature; the anthracene and quinone derivatives contained in the rhubarb have the purgation function, and the purgation does not obstruct the absorption of nutrient substances by small intestines; folium Isatidis and Natrii sulfas are adjuvant drugs, and have effects of clearing away pathogenic heat and toxic materials, and eliminating jaundice in yellow Han, and can be used for treating fever. The medicines are compatible and play a role in clearing away heat and toxic materials, purging fire and relaxing bowels, resisting virus, reducing fever and high temperature and purgation. The first component and the second component act together, so that the pestilence can be effectively treated in the pestilence peak period.

Detailed Description

The invention provides a traditional Chinese medicine composition for treating livestock plague, which comprises a first component and a second component; the first component comprises the following components in parts by weight: 25 parts of radix glehniae, 5 parts of liquorice, 7.5 parts of bistort rhizome, 14 parts of lacca, 50 parts of elecampane, 25 parts of rubus corchorifolius, 50 parts of radix sophorae flavescentis, 12.5 parts of rhizoma kaempferiae, 25 parts of myrobalan, 15 parts of szechwan chinaberry fruit and 30 parts of gardenia; the second component comprises the following components in parts by weight: 60 parts of dyers woad leaf, 60 parts of isatis root, 60 parts of gypsum, 30 parts of rhubarb and 30 parts of glauber salt.

The first component of the medicine for treating the pestilence of the livestock takes the lightyellow sophora root and the coastal glehnia root as monarch medicines, the lightyellow sophora root has the effects of clearing heat, inhibiting bacteria, promoting urination and relieving pain, the coastal glehnia root has the effects of clearing blood heat and lung heat, and the lacca sinensis is used as an adjuvant medicine. The liquorice is matched as an adjuvant drug to relieve cough and eliminate phlegm. Bistort rhizome is an adjuvant drug and has the effects of clearing lung heat and detoxifying so as to achieve the effect of treating pyretic pulmonary disease and various heat type cough and dyspnea. Elecampane, rhizoma kaempferiae, myrobalan, szechwan chinaberry fruit and gardenia are used as ministerial drugs to play the effects of clearing pestilence, relieving exterior syndrome, detoxifying and cooling blood; the Rubus alceaefolius Linnaeus is an adjuvant drug, has effects of relieving exterior syndrome, eliminating Heryi heat, relieving cough and resisting bacteria. In the second component, the radix isatidis is a monarch drug, and the contained syringic acid, anthranilic acid, salicylic acid and the like in the radix isatidis have the function of resisting endotoxin, and have the function of inhibiting hemorrhagic fever with renal syndrome, encephalitis B virus, mumps virus, herpes simplex virus, hepatitis B virus and the like; gypsum and radix et rhizoma Rhei are ministerial drugs, wherein the gypsum can promote macrophage phagocytosis of endogenous pyrogen to generate endogenous pyrogen, and lower body temperature; the anthracene and quinone derivatives contained in the rhubarb have the purgation function, and the purgation does not obstruct the absorption of nutrient substances by small intestines; folium Isatidis and Natrii sulfas are adjuvant drugs, and have effects of clearing away pathogenic heat and toxic materials, and eliminating jaundice in yellow Han, and can be used for treating fever. The medicines are compatible and play a role in clearing away heat and toxic materials, purging fire and relaxing bowels, resisting virus, reducing fever and high temperature and purgation. The first component and the second component act together, so that the pestilence can be effectively treated in the pestilence peak period.

The sources of the radix glehniae, the liquorice, the bistort rhizome, the lacca, the elecampane, the raspberry, the radix sophorae flavescentis, the rhizoma kaempferiae, the myrobalan, the szechwan chinaberry fruit, the gardenia, the folium isatidis, the radix isatidis, the gypsum, the rhubarb and the exsiccated sodium sulfate are not particularly limited, and the conventional commercial products in the field can be adopted. The embodiment of the invention is purchased from a national defense pharmacy.

In the invention, the dosage of the medicine is preferably 0.75-1 g, more preferably 0.9g per 1Kg of body weight of livestock.

In the invention, the dosage form of the medicine is powder. The preparation method of the powder is not particularly limited, and the powder can be prepared by crushing by adopting a conventional crushing method in the field.

In the present invention, the powder is preferably administered directly or by decocting the first component to obtain a decoction of the first component, and then soaking the second component in the decoction of the first component.

In the present invention, the method of decoction preferably comprises the steps of:

1) Mixing the first component with water to obtain a total mixture;

in the present invention, the mass volume ratio of the first component to water is preferably 1g:7m L.

After the total mixture is obtained, the total mixture is preferably decocted to boil and then decocted for 8-12 min, and more preferably for 10 min.

In the invention, the soaking time is preferably 13-17 min, and more preferably 15 min. In the invention, the soaking is preferably carried out after the first component decoction is cooled.

In the present invention, the livestock plague preferably comprises livestock foot and mouth disease, highly pathogenic avian influenza, bunion, highly pathogenic porcine reproductive and respiratory syndrome, swine fever, newcastle disease, bovine tuberculosis, anthrax, rabies, pseudorabies, melioidis, equine poverty, equine influenza, mad cow disease, scrapie, bluetongue, goat/sheep pox, small ruminant disease, sheep triple disease, swine encephalitis B, swine parvovirus disease, porcine circovirus disease, swine streptococcosis, African swine fever, and canine distemper.

The invention provides application of the traditional Chinese medicine composition for treating the livestock plague in the scheme to treatment of the livestock plague. In the invention, the traditional Chinese medicine composition for treating the livestock plague is preferably used in the peak period and the later period of the plague.

In order to further illustrate the present invention, the following embodiments are described in detail, but they should not be construed as limiting the scope of the present invention.

Example 1

weighing 25g of radix glehniae, 5g of liquorice, 7.5g of bistort rhizome, 14g of lacca, 50g of elecampane, 25g of rubus corchorifolius, 50g of radix sophorae flavescentis, 12.5g of rhizoma kaempferiae, 25g of myrobalan, 15g of szechwan chinaberry fruit and 30g of gardenia, crushing to obtain a first group of dispersing agents, weighing 60g of folium isatidis, 60g of radix isatidis, 60g of gypsum, 30g of rheum officinale and 30g of glauber salt, crushing to obtain a second group of dispersing agents, mixing the obtained first group of dispersing agents with water according to the ratio of 1g to 7m L, decocting until boiling, decocting for 10min to obtain a first group of decoction, cooling, soaking the second group of dispersing agents into the first group of decoction, and soaking for 15 min.

Example 2

400 diseased sheep suffering from plague (diarrhea, rhinorrhea, lacrimation, high fever at body temperature of 40-42 ℃, inability to get up in lying ground and inappetence) are randomly divided into two groups, 200 sheep in each group are taken as an experimental group, one group is taken as a control group, the experimental group is drenched with the medicine prepared by the method of example 1 (0.75-1 g is taken for 1kg of body weight of the sheep and taken once every 48 h), the control group is taken as Ganfei Xiehuoling (decoction medicine, 5-10 m L is taken for each sheep and taken once every 24 h), and the treatment effect is observed after the experimental group and the control group are taken for 5 days, which is specifically shown in Table 1.

TABLE 1 Effect of different treatments

As can be seen from the table 1, the medicine prepared by the invention can effectively treat the plague of the livestock, the effective rate reaches 97 percent, and is improved by 28 percent compared with the control group.

Example 3

In 12 months and 14 days in 2014, more than 300 sheep in Alason, A, S, E, G, E. 3-7 sheep die each day.

The sheep with the disease continuously suffered (more than 200 sheep) are randomly divided into two groups, one group is used as an experimental group (150 sheep), the other group is used as a control group (80 sheep), the experimental group adopts the method of the embodiment 1 to prepare the medicine, and the prepared medicine is drenched into the sheep flock (the weight of the sheep is calculated, and the weight of 1kg is 0.75-1 g). The Chinese medicinal composition is taken by drenching once a day, the symptoms are relieved in the first day, one sheep is killed, the effect is obvious after drenching the Chinese medicinal composition for the second day, and the illness state is recovered to be normal after continuous three times of administration.

in the control group, 5g of ceftiofur sodium injection and 1 g of ceftiofur sodium injection are adopted, 1 to 10m L astragalus polysaccharide injection (intramuscular injection in the morning) is filled with 10m L poplar flower dysenteriae, after 8 hours, 10m L isatis root injection (intramuscular injection on the left) and 10m L vitamin B complex injection (intramuscular injection on the right) are filled, 8-10 flonicacid capsules are filled simultaneously, 10-15m L double coptis chinensis oral liquid is filled in the noon, 10m L analgin injection is injected into the left muscle in the afternoon and 10m L sulfanilamide injection is injected into the right muscle in the next day alternately, injection of western medicines and injection treatment effects are not obvious, and the death rate reaches 38%.

Example 4

Two groups of sheep of Shajin Cuyabayan Bayin Wula Ga Hope Mudange and Jia Gui Zhong stang 1486 sheep in 6 months and 8 days at 2016, the sudden illness of more than 50 percent of sheep is diluted, the nose flows and the tears flows, the body temperature rises to 40-42 ℃, the disease sheep in the two groups continue about 6 days, a large part of diseased sheep appears in the two groups of sheep, the diseased sheep is accompanied by transient stiff gait, the foot end is heated, the body temperature slightly rises, the death rate is about 60 percent, injection medicines such as ceftiofur sodium, astragalus polysaccharide sulfonamides, analgin, compound VB and the like are adopted for injection, and the injection medicines such as disinfection, disease sheep isolation, small ruminant vaccine preparation, serum preparation and the like are adopted for treatment, and the effect is not obvious. Finally, after the medicine is prepared by the method of example 1, the prepared medicine is drenched into a sheep flock (0.75-1 g is taken according to the weight of the sheep for 1 kg). The disease condition is obviously improved after the medicine is taken for three times every day, and the medicine has good effect.

Example 5

20 days 12 months in 2017, more than 800 sheep in the ancient hercules of albas mountain herdsman in the southern area of hai, ukhai, infect the ruminants epidemic disease, and the ancient says that a plurality of drug effect effects are not obvious. After half a month of using the drug prepared by the method of example 1 of the present invention, the herd of sheep returned to normal.

Most typically, the diseases are between 2018 and 20 months and 2018 and between 7 and 6 months, the sudden infectious diseases of more than 800 sheep peste ruminants are treated in the trachomatis, shanjin, haya, braziga, shin city, expected graph gate, Jiri, gla staffs 800 sheep, the veterinarian from the mainhouse to the shankou county requests a subordinate senior veterinarian to diagnose and treat, and the veterinarian requests the veterinarian to diagnose and treat in the baud city, so that the flocks of sheep are basically recovered to be normal after the medicament prepared in the embodiment 1 of the invention is used for treating half a month under the condition that the effect is not obvious.

Example 6

2015 year 3 month 9 days, the disease of 1700 sheep of two families of sarin staygga, hernans, Yangla and Sexila, disease symptoms: only a small part of the blisters on the hoof are damaged, but broad bean big blisters are generated on the whole oral mucosa (except for the tongue), the blister wall is thin and is rapidly broken, and the scarlet rotten ban with irregular edges is left after the breaking, which is called erosive stomatitis, and the healing process lasts for 3 weeks. Systemic symptoms: rhinitis and the head part of the affected sheep is shrunken and rises, which causes the appearance of the affected sheep to change, so the affected sheep is called as a big head disease. The temperature of the foot end is increased, but the hoof does not generate bubbles. When advanced veterinarians of the county animal husbandry office suspicion that the foot-and-mouth disease is caused, ceftiofur sodium is used for intramuscular injection of astragalus polysaccharide or naproxen intramuscular injection and the like, and No. 5 vaccine is applied, serum is applied, the isolation effect of the affected sheep is not obvious, and the disease incidence is increased, the effect is obvious and good after the medicine prepared by the method of the embodiment 1 of the invention is taken twice, and the medicine is recovered to be normal after being taken for 1 week.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A Chinese medicinal composition for treating pestilence in livestock comprises a first component and a second component; the first component comprises the following components in parts by weight: 25 parts of radix glehniae, 5 parts of liquorice, 7.5 parts of bistort rhizome, 14 parts of lacca, 50 parts of elecampane, 25 parts of rubus corchorifolius, 50 parts of radix sophorae flavescentis, 12.5 parts of rhizoma kaempferiae, 25 parts of myrobalan, 15 parts of szechwan chinaberry fruit and 30 parts of gardenia;

The second component comprises the following components in parts by weight:

2. The traditional Chinese medicine composition for treating livestock plague according to claim 1, characterized in that the dosage of the medicine is 0.75-1 g per 1Kg of body weight of livestock.

3. The traditional Chinese medicine composition for treating livestock plague according to claim 1 or 2, characterized in that the dosage form of the medicine is powder.

4. The traditional Chinese medicine composition for treating livestock plague according to claim 3, characterized in that the powder is taken directly or by decocting the first component to obtain a decoction of the first component and soaking the second component in the decoction of the first component for administration.

5. The traditional Chinese medicine composition for treating livestock plague according to claim 4, characterized in that the decoction method comprises the following steps:

1) Mixing the first component with water to obtain a total mixture;

6. the traditional Chinese medicine composition for treating livestock plague according to claim 5, characterized in that the mass to water volume ratio of the first component in step 1) is 1g:7m L.

7. The traditional Chinese medicine composition for treating livestock plague according to claim 4, characterized in that the soaking time is 13-17 min.

8. The traditional Chinese medicine composition for treating livestock plague according to claim 1 or 2, characterized in that the livestock plague comprises foot and mouth disease, highly pathogenic avian influenza, brood, highly pathogenic blue-ear pig disease, swine fever, newcastle disease, bovine tuberculosis, anthrax, rabies, pseudorabies, meliitus equinovarum, equine poverty, equine influenza, mad cow disease, scrapie, bluetongue, goat/sheep pox, small ruminant disease, sheep three diseases, swine encephalitis B, swine parvovirus disease, porcine circovirus disease, swine streptococcosis, African swine fever and canine distemper.