CN111184823A

CN111184823A - A fumigation bath preparation for preventing and treating pestilence, and its application method and application

Info

Publication number: CN111184823A
Application number: CN202010108546.4A
Authority: CN
Inventors: 杨汉梅; 陈彩虹; 陈天跃; 杨仪鏐
Original assignee: Guizhou Miao Zhentang Health Technology Development Co Ltd
Current assignee: Guizhou Miao Zhentang Health Technology Development Co Ltd
Priority date: 2020-02-21
Filing date: 2020-02-21
Publication date: 2020-05-22

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a fumigation bath preparation for preventing and treating pestilence and a using method and application thereof. The fumigation bath preparation is prepared from the following raw materials in parts by weight: 8-12 parts of semiliquidambar cathayensis, 8-12 parts of cinnamomum camphora root, 8-12 parts of citronella, 8-12 parts of sculellaria barbata, 8-12 parts of giant knotweed rhizome, 8-12 parts of honeysuckle stem, 8-12 parts of weeping forsythia, 8-12 parts of dandelion, 8-12 parts of radix bupleuri, 8-12 parts of cynanchum glaucescens, 8-12 parts of bitter apricot kernel, 8-12 parts of aster, 8-12 parts of reed rhizome and 8-12 parts of euphorbia lathyris. The fumigation bath preparation provided by the invention has the effects of sweating with pungent and warm natures, relieving exterior syndrome with pungent and cool natures, dispelling wind and heat, clearing plague and detoxifying, clearing damp and detoxifying, ventilating and dispersing lung and expelling pathogenic factors, and can promote human metabolism and circulation and improve human immunity; has good prevention and treatment effects on novel coronavirus pneumonia patients and plague patients with syndrome of dampness-pathogen stagnating in lung, syndrome of cold-dampness stagnating in lung, syndrome of epidemic toxin blocking in lung, and syndrome of wind-heat invading lung. The application method is simple, convenient, cheap, and quick, and has no side effects on intestine, stomach, liver and kidney.

Description

A fumigation bath preparation for preventing and treating pestilence, and its application method and application

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a fumigation bath preparation for preventing and treating pestilence and a using method and application thereof.

Background

Plague is an acute infectious disease caused by some strongly pathogenic microorganisms, such as bacteria and viruses. Acute infectious diseases such as smallpox, plague, SARS, avian influenza and the like belong to the category of plague. From ancient times to present, pestilence is repeatedly epidemic, and has brought a profound disaster to the world and Chinese nationalities. For example, as recorded in Lushi spring and autumn and spring era: "summer season in spring, people are infected with diseases. "it shows that the understanding of pestilence at that time has reached a certain level, and it is considered that pestilence can occur all the year round, one of the reasons is that the abnormality of seasonal qi is caused by" untimely qi ". In the beginning of the 20 th century, cholera and plague occur for many times, and SARS in the beginning of the century brings huge influence and disasters to China. Most of the plagues are acute respiratory tract infections caused by influenza viruses, and are also diseases with strong infectivity and high transmission speed. It is mainly transmitted by the spray in the air, the contact between people or the contact and spread of the contaminated articles; it is characterized by strong variability.

The new type coronavirus pneumonia, New Crown Pneumonia (NCP) for short, is an acute respiratory infectious disease caused by 2019 new type coronavirus (SARS-CoV-2) infection, and belongs to pestilence in traditional Chinese medicine. The clinical manifestations of patients with pneumonia infected by the novel coronavirus are: it is mainly manifested as fever, fatigue and dry cough. The symptoms of upper respiratory tract such as nasal obstruction and nasal discharge are rare. Approximately half of patients develop dyspnea after one week, and severe patients rapidly progress to acute respiratory distress syndrome, septic shock, refractory metabolic acidosis, and procoagulant dysfunction. It is noted that the severe and critically ill patients may have moderate or low fever during their course, even without significant fever. At present, no specific medicine for treating novel coronary virus pneumonia exists.

The traditional Chinese medicine is a medical theory system which is gradually formed and developed through long-term medical practice under the guidance of ancient naive materialism and spontaneous dialectical thought. The traditional Chinese medicine has an advantage position in the treatment of pestilence, and has remarkable achievement in preventing and treating serious viral infection such as influenza, measles, dengue fever, SARS and the like; in particular, the efficacy of SARS has gained the popularity and importance of the world health organization, advocating the use of Chinese medicine for the treatment and prevention of infectious diseases. The research on the prevention and treatment of pestilence of traditional Chinese medicine also becomes the focus of attention in the field of modern medicine.

At present, there are many researches on the prevention and treatment of acute respiratory infection caused by influenza virus in traditional Chinese medicine. For example, the patent with publication number CN108186867A discloses a Chinese medicinal composition for treating viral influenza, which comprises 20-40 parts of honeysuckle, 10-20 parts of forsythia, 10-20 parts of dandelion, 10-20 parts of folium isatidis, 10-20 parts of radix isatidis, 10-20 parts of houttuynia cordata, 10-20 parts of scutellaria baicalensis, 10-20 parts of blackberry lily, 10-20 parts of gypsum, 10-20 parts of fritillaria, 5-15 parts of arisaema cum bile, 5-15 parts of almond, 5-15 parts of pinellia ternate, 5-15 parts of platycodon grandiflorum, 5-15 parts of loquat leaf, 5-15 parts of aster, 5-15 parts of inula flower, 5-15 parts of common coltsfoot flower, 5-15 parts of radix bupleuri and 2-6 parts of liquorice. The traditional Chinese medicine components in the invention are scientifically compatible and cooperate, the immunity of a patient is obviously improved, and the traditional Chinese medicine composition has obvious effects of treating viral cold, high fever, myalgia, headache, cough, phlegm, dry cough, continuous breathing and sore throat.

Also, for example, patent publication No. CN109528943A discloses a formulation and preparation of anti-influenza Chinese medicinal highly concentrated pill, which comprises the following components in parts by weight: 9-10 parts of dandelion, 9-10 parts of common andrographis herb, 9-10 parts of houttuynia cordata, 9-10 parts of isatis root, 9-10 parts of kudzu-vine root, 9-10 parts of gypsum, 9-10 parts of reed rhizome, 4-5 parts of folium isatidis, 4-5 parts of fructus forsythiae, 4-5 parts of scutellaria baicalensis, 2.5-3.5 parts of honeysuckle, 2.5-3.5 parts of perilla leaf, 2.5-3.5 parts of radix bupleuri, 2.5-3.5 parts of cassia twig, 2.5-3.5 parts of almond, 2.5-3.5 parts of raw licorice, 2.5-3.5 parts of platycodon grandiflorum and 2-3 parts of ephedra herb. The highly concentrated pills prepared by the method have the effects of clearing away heat and toxic materials, dispelling wind and eliminating evil, and the clinical effect is close to that of decoction.

The medicine provided by the patent adopts an oral administration mode, and has certain side effects on intestines, stomach, liver and kidney.

Disclosure of Invention

The invention provides a fumigation bath preparation for preventing and treating pestilence, a using method thereof and application thereof in preventing and treating novel coronavirus pneumonia by researching traditional medicines, and the fumigation bath preparation is realized by the following technical scheme:

a fumigation bath preparation for preventing and treating pestilence is prepared from the following raw materials in parts by weight: 8-12 parts of semiliquidambar cathayensis, 8-12 parts of cinnamomum camphora root, 8-12 parts of citronella, 8-12 parts of sculellaria barbata, 8-12 parts of giant knotweed rhizome, 8-12 parts of honeysuckle stem, 8-12 parts of weeping forsythia, 8-12 parts of dandelion, 8-12 parts of radix bupleuri, 8-12 parts of cynanchum glaucescens, 8-12 parts of bitter apricot kernel, 8-12 parts of aster, 8-12 parts of reed rhizome and 8-12 parts of euphorbia lathyris.

Preferably, the fumigation bath preparation for preventing and treating pestilence is prepared from the following raw materials in parts by weight: 9 parts of semiliquidambar cathayensis, 9 parts of cinnamomum camphora root, 9 parts of citronella, 9 parts of sculellaria barbata, 9 parts of giant knotweed, 9 parts of honeysuckle stem, 9 parts of weeping forsythia, 9 parts of dandelion, 9 parts of radix bupleuri, 9 parts of cynanchum glaucescens, 9 parts of bitter apricot seed, 9 parts of aster, 9 parts of reed rhizome and 9 parts of lysimachia christinae hance.

Preferably, the preparation method of the fumigation bath preparation for preventing and treating the plague comprises the steps of preparing the medicines according to the parts by weight, drying the prepared medicines at 70 ℃, crushing the medicines into 60 meshes, and subpackaging the medicines into fumigation bath preparations of which each bag is 20-30 g.

The invention also provides a using method of the fumigation bath preparation, which comprises the following steps: putting 20-30g of the fumigation bath preparation into a decocting pot, adding 3L of cold water, decocting for 15-20 minutes, firstly decocting with slow fire for 10-12 minutes, then decocting with strong fire for 5-8 minutes, and keeping constant temperature after decocting to boil; then, conveying steam generated by the boiling pot to a sealed fumigating wooden barrel, and when the temperature in the barrel reaches 60 ℃, enabling a human body to enter the barrel, and placing the head part outside the barrel; keeping the temperature in the fumigating barrel at 40-48 deg.C, and performing fumigation bath for 10-30 min; the bath is carried out for 1 time every day, 15 days are a treatment course, 7 days are a small treatment course, and the bath is carried out continuously for 3 days for rest for one day.

Preferably, the temperature in the decocting pot is kept at 92-95 ℃.

The invention also provides application of the fumigation bath preparation in preventing and treating novel coronavirus pneumonia.

The traditional Chinese medicine adopts syndrome differentiation for treating the pestilence. Clinically, pestilence patients can be classified into syndrome of pathogenic dampness stagnating in the lung, syndrome of cold-dampness stagnating in the lung, syndrome of epidemic toxin blocking in the lung, syndrome of wind-heat invading the lung, etc.; clinically manifested as low fever or no fever, dry throat, dry cough, lassitude, chest distress, little phlegm, hypodynamia, gastric fullness, loose stool or nausea; pale or reddish tongue, soft-superficial pulse, white or white and greasy coating; persistent fever or alternating cold and heat, cough with little sputum, or yellow sputum, abdominal distention, constipation, chest distress, short breath, cough with dyspnea, etc. The novel coronavirus pneumonia belongs to the category of pestilence in traditional Chinese medicine and is caused by pestilential qi hurting people; when the human body has low immunity, the human body is easy to be infected by pathogenic wind, cold, dampness and toxin; the disease location is mainly in the lung and has extremely strong infectivity.

In the bath preparation of the invention: the semiliquidambar cathayensis has the effects of dispelling wind and eliminating dampness; radix Litseae Rubescentis has effects of warming middle-jiao to relieve pain, keeping clear and shining, regulating stomach, regulating qi-flowing, regulating blood, dispelling pathogenic wind and removing dampness; the citronella has the effects of resisting bacteria, relieving itching, dispelling wind, dredging collaterals, relieving cough and asthma; sculellaria barbata-heat clearing and detoxifying, stasis removing and diuresis promoting; giant knotweed rhizome for clearing away heat and toxic material; caulis Lonicerae has antibacterial, antiinflammatory, lung moistening, and cough relieving effects; fructus forsythiae; clearing away heat and toxic materials, relieving swelling, dispersing pathogen accumulation, relieving inflammation, promoting urination, and resisting virus; the dandelion has the functions of bacteriostasis, detumescence and detoxification; radix bupleuri has effects of dispelling and relieving fever, preventing abuse, dispersing stagnated liver qi, and lifting yang qi; rhizoma Cynanchi Stauntonii has the effects of purging lung-fire, lowering qi, expelling phlegm and relieving cough; bitter apricot kernel can relieve cough and asthma, moisten intestines and relax bowels; radix Asteris cow can be used for treating cough and asthma due to wind-cold evil, eliminating phlegm, resisting bacteria and virus; rhizoma Phragmitis has effects of promoting fluid production, clearing heat and promoting diuresis. The medicines in the formula are combined to play the effects of pungent and warm sweating, pungent and cool exterior syndrome relieving, wind and heat dispelling, plague clearing and detoxifying, dampness eliminating and detoxifying, lung ventilating and pathogen expelling, and simultaneously can promote the metabolism and circulation of a human body and improve the immunity of the human body; has good prevention and treatment effects on pestilence patients with syndrome of dampness-pathogen stagnating in lung, syndrome of cold-dampness stagnating in lung, syndrome of epidemic toxin blocking in lung, and syndrome of wind-heat invading lung, and patients with novel coronavirus pneumonia.

The traditional Chinese medicines used in the field of treating pestilence in the prior art are mainly orally taken, for example, patent publication nos. CN108186867A and CN109528943A in the background art. Compared with the prior art, the technical scheme provided by the invention has the following advantages: 1. no good medicine bitter taste is needed; ecological health, safety, environmental protection, no pain, little toxic and side effect and reduced phytotoxicity. 2. The Chinese medicinal composition has the side effects of three-part toxin, liver and kidney injury caused by oral administration, stimulation to gastrointestinal tracts and the like, and the disease is usually caused by not treating the disease, so that the disease is usually caused by treating the disease, toxin is removed from a patient and the immunity is improved, but the toxin is increased to the patient as a result. 3. The oral traditional Chinese medicine has bitter and astringent taste and heavy medicine taste, so that some patients cannot tolerate the oral traditional Chinese medicine, the patients cannot enter the mouth or enter the mouth to regurgitate and vomit, and the treatment time of the patients is delayed. 4. The fumigation bath therapy has quick response and less medicine consumption; the fumigation bath preparation of the invention is taken 20-30g every day, can take effect after 1 time, and has the effect which can not be achieved by oral administration. The dosage of the oral traditional Chinese medicine is far greater than that of the fumigation bath preparation, and the medicines reaching the target point are remained a few by gastrointestinal digestion and absorption and related viscera transportation, so the treatment effect is not as good as that of the fumigation bath treatment. 5. The fumigation bath therapy has the function of sweating in the treatment process, can quickly and well regulate the circulation and metabolism of a human body, strengthen the effect of expelling toxin and improve the immunity; oral administration of Chinese herbs can not achieve the technical effect. 6. The fumigation bath therapy is simple, convenient, cheap and effective, has wide audience and is easy to accept by people.

The invention adopts a fumigation bath therapy, is based on the traditional Chinese medicine, achieves the effects of treating cold and heat diseases and treating internal diseases by taking skin medicine taking as a way through the bidirectional effect of the medicine steaming power and the heating power of the Miao medicine and the human body according to the principle of the Miao medicine 'two lines', and the medicine is absorbed through the skin without oral administration and directly distributed to the internal circulation through capillary vessels, thereby having the advantages of less medicine consumption, quick response and no side effect on intestines, stomach, liver and kidney. The fumigation bath therapy can expel toxin through the 'sweating' effect of the fumigation bath, can improve the immunity of a human body, can perspire without hurting ying and defending, can ensure that vital qi is remained, can not be cheated by pathogenic factors, and has the effect which cannot be achieved by oral administration.

The fumigation bath preparation provided by the invention has the effects of sweating with pungent and warm natures, relieving exterior syndrome with pungent and cool natures, dispelling wind and heat, clearing plague and detoxifying, clearing damp and detoxifying, ventilating and dispersing lung and expelling pathogenic factors, and can promote human metabolism and circulation and improve human immunity; has good prevention and treatment effects on pestilence patients with syndrome of dampness-pathogen stagnating in lung, syndrome of cold-dampness stagnating in lung, syndrome of epidemic toxin blocking in lung, and syndrome of wind-heat invading lung, and patients with novel coronavirus pneumonia. The application method is simple, convenient, cheap, and quick, and has no side effects on intestine, stomach, liver and kidney.

Detailed Description

The technical solution of the present invention is further defined below with reference to the specific embodiments, but the scope of the claims is not limited to the description.

Example 1

The formula is as follows: 9g of semiliquidambar cathayensis, 9g of cinnamomum camphora root, 9g of citronella, 9g of sculellaria barbata, 9g of giant knotweed, 9g of honeysuckle stem, 9g of fructus forsythiae, 9g of dandelion, 9g of radix bupleuri, 9g of cynanchum glaucescens, 9g of bitter apricot seed, 9g of aster, 9g of rhizoma phragmitis and 9g of euphorbia lathyris.

The above formula is prepared according to 100 parts, the prepared medicines are dried at 70 ℃, crushed to 60 meshes and subpackaged into 20-30g of fumigation bath preparation per bag.

Example 2

The formula is as follows: 8g of semiliquidambar cathayensis, 10g of cinnamomum camphora root, 10g of citronella, 8g of sculellaria barbata, 10g of giant knotweed, 10g of honeysuckle stem, 8g of fructus forsythiae, 12g of dandelion, 10g of radix bupleuri, 8g of cynanchum glaucescens, 10g of bitter apricot seed, 10g of aster, 8g of rhizoma phragmitis and 10g of euphorbia lathyris.

Example 3

The formula is as follows: 10g of semiliquidambar cathayensis, 8g of cinnamomum camphora root, 12g of citronella, 10g of sculellaria barbata, 12g of giant knotweed, 10g of honeysuckle stem, 8g of fructus forsythiae, 10g of dandelion, 8g of radix bupleuri, 10g of cynanchum glaucescens, 8g of bitter apricot seed, 10g of aster, 8g of rhizoma phragmitis and 8g of euphorbia lathyris.

Example 4

The formula is as follows: 12g of semiliquidambar cathayensis, 12g of cinnamomum camphora root, 8g of citronella, 12g of sculellaria barbata, 8g of giant knotweed, 10g of honeysuckle stem, 8g of forsythia, 8g of dandelion, 12g of radix bupleuri, 12g of cynanchum glaucescens, 12g of bitter apricot seed, 12g of aster, 12g of reed rhizome and 12g of euphorbia lathyris.

Test examples

1. Patient data

416 cases of influenza lung syndrome patients are confirmed to be treated by national medical hospitals in the Miao steam hall of southeast Guizhou province. Symptoms are: low fever or no fever, aversion to cold, fever or no fever, no fever or alternating fever and chills; light cough, dry cough; little or yellow sputum; dry throat, sore throat, lassitude, hypodynamia, absence of sweat and chest distress; gastric fullness, or nausea; loose stool, abdominal distension and constipation; cough with little sputum, yellow sputum and cough with little sputum; or yellow phlegm, chest distress, short breath, cough, dyspnea, and asthma when in motion. The traditional Chinese medicine syndrome differentiation is carried out according to the traditional Chinese medicine syndrome diagnosis curative effect standard: 123 cases of lung stagnation due to damp pathogen, 106 cases of lung stagnation due to cold and damp, 90 cases of lung blockage due to epidemic toxin, and 97 cases of lung invasion due to wind-heat.

2. Method of treatment

Fumigation treatments were carried out using the fumigants prepared in examples 1-4: putting 20-30g of the fumigation bath preparation into a decocting pot, adding 3L of cold water, decocting for 15-20 minutes, firstly decocting with slow fire for 10-12 minutes, then decocting with strong fire for 5-8 minutes, and keeping the constant temperature at 92-95 ℃ after the decoction is boiled; then, conveying steam generated by the boiling pot to a sealed fumigating wooden barrel, and when the temperature in the barrel reaches 60 ℃, enabling a human body to enter the barrel, and placing the head part outside the barrel; keeping the temperature in the fumigating barrel at 40-48 deg.C, and performing fumigation bath for 10-30 min; the bath is carried out for 1 time every day, 15 days are a treatment course, 7 days are a small treatment course, and the bath is carried out continuously for 3 days for rest for one day. Specific treatment data are shown in table 1:

TABLE 1

3. Therapeutic results

As shown in tables 2 and 3:

TABLE 2

TABLE 3

According to the clinical treatment tests, the fumigation bath agent provided by the invention has good treatment effect on the syndrome of pathogenic dampness stagnating in the lung, the syndrome of cold-dampness stagnating in the lung, the syndrome of epidemic toxin blocking in the lung and the syndrome of wind-heat invading the lung of influenza; the symptoms can be eliminated by generally fumigating and bathing for 3-7 times, the effective rate is more than 95%, and the cure rate is more than 85%; the symptoms of epidemic toxin blocking the lung and wind-heat attacking the lung can be eliminated by 7-15 times of fumigation bath, the effective rate is more than 90%, and the cure rate is more than 80%.

The novel coronavirus pneumonia COVID-19 outbreak in 2019 belongs to the category of pestilence in traditional Chinese medicine, and is classified into four symptoms of dampness stagnating in lung, heat evil obstructing in lung, pathogen obstructing in lung and internal obstruction and external collapse according to syndrome differentiation and treatment of traditional Chinese medicine symptoms. The syndrome of dampness-evil stagnation in the lung, the syndrome of cold-dampness stagnation in the lung, the syndrome of epidemic toxin blocking the lung and the syndrome of wind-heat invading the lung which are prevented and treated by the fumigation bath preparation are the early symptoms of four symptoms of dampness-evil stagnation in the lung, heat evil blocking in the lung, evil toxin blocking in the lung and internal block and external collapse, if the symptoms of a patient are not effectively controlled in the period, the patient can suffer from fever or high fever, viruses can further aggravate the infection of the lung, the symptoms of the heat, dyspnea and the like are appeared, the symptoms of the middle period and the later period can be aggravated, and finally the early prevention and control are very important. Therefore, the method provided by the invention can effectively prevent the novel coronary pneumonia and treat the patients with mild symptoms.

It should be noted that the above examples and test examples are only for further illustration and understanding of the technical solutions of the present invention, and are not to be construed as further limitations of the technical solutions of the present invention, and the invention which does not highlight essential features and significant advances made by those skilled in the art still belongs to the protection scope of the present invention.

Claims

1. A fumigation bath preparation for preventing and treating pestilence is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of semiliquidambar cathayensis, 8-12 parts of cinnamomum camphora root, 8-12 parts of citronella, 8-12 parts of sculellaria barbata, 8-12 parts of giant knotweed rhizome, 8-12 parts of honeysuckle stem, 8-12 parts of weeping forsythia, 8-12 parts of dandelion, 8-12 parts of radix bupleuri, 8-12 parts of cynanchum glaucescens, 8-12 parts of bitter apricot kernel, 8-12 parts of aster, 8-12 parts of reed rhizome and 8-12 parts of euphorbia lathyris.

2. The fumigation bath preparation for preventing and treating pestilence according to claim 1, which is prepared from the following raw materials in parts by weight: 9 parts of semiliquidambar cathayensis, 9 parts of cinnamomum camphora root, 9 parts of citronella, 9 parts of sculellaria barbata, 9 parts of giant knotweed, 9 parts of honeysuckle stem, 9 parts of weeping forsythia, 9 parts of dandelion, 9 parts of radix bupleuri, 9 parts of cynanchum glaucescens, 9 parts of bitter apricot seed, 9 parts of aster, 9 parts of reed rhizome and 9 parts of lysimachia christinae hance.

3. The fumigation bath preparation for preventing and treating pestilence according to claim 1 or 2, which is prepared by mixing the above raw materials in parts by weight, oven drying at 70 deg.C, pulverizing to 60 mesh, and subpackaging into 20-30g fumigation bath preparation per bag.

4. A method for using the fumigation bath preparation for preventing and treating the pestilence according to any one of claims 1 to 3, characterized in that 20 to 30g of the fumigation bath preparation is put into a decocting pot, 3L of cold water is added for decocting for 15 to 20 minutes, slow fire and strong fire are firstly added during the decocting, and the temperature is kept constant after the decocting is carried out till the boiling; then, steam generated by the boiling pot is conveyed to a sealed fumigating wooden barrel, when the temperature in the barrel reaches 60 ℃, a human body enters the barrel for fumigating bath, and the head part of the human body is arranged outside the barrel; the bath is carried out for 1 time every day, 15 days are a treatment course, 7 days are a small treatment course, and the bath is carried out continuously for 3 days for rest for one day.

5. The application method of the fumigation bath preparation for preventing and treating pestilence of claim 4, wherein the temperature in the barrel during fumigation is maintained at 40-48 deg.C, and fumigation bath is carried out for 10-30 min.

6. The use method of the fumigation bath preparation for preventing and treating the pestilence according to claim 4, characterized in that the decoction is carried out by slow fire for 10-12 minutes and then by strong fire for 5-8 minutes.

7. The use method of the fumigation bath preparation for preventing and treating pestilence of claim 4, wherein the constant temperature in the decocting pot is kept at 92-95 ℃.

8. Use of a fumigation bath preparation for preventing and treating plague according to any one of claims 1 to 3 in preventing and treating novel coronavirus pneumonia COVID-19.

9. The use of claim 8, wherein the novel coronavirus pneumonia COVID-19 is clinically manifested as syndrome of pathogenic stagnation in lung, syndrome of cold-damp stagnation in lung, syndrome of epidemic toxin blocking lung, syndrome of wind-heat invading lung.