CN109464521B - Traditional Chinese medicine composition for preventing and treating chicken bronchial embolism - Google Patents
Traditional Chinese medicine composition for preventing and treating chicken bronchial embolism Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating chicken bronchial embolism. The traditional Chinese medicine composition is prepared from cassia twig, ephedra, bitter apricot seed, folium isatidis, pummelo peel, liquorice and gypsum. Has effects in dispersing lung qi, relieving asthma, clearing away heat, and eliminating phlegm; has good clinical prevention and treatment effect on the bronchial embolism of the chicken caused by cold, lung heat cough and asthma or other respiratory diseases.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating chicken bronchial embolism.
Background
The bronchus embolism is a serious comprehensive and epidemic respiratory disease widely occurring in northern areas of China in recent years, occurs in chicken farms of different scales, different varieties and different breeding modes, has high disease incidence speed, difficult treatment and high death rate, and brings huge economic loss to vast farmers.
The trachea ring of the chicken suffering from the bronchial embolism is congested and bleedings, and the yellow-white cheese-like substances are often blocked in the trachea and the bronchus at the joint of the bronchus and the lung. Congestion and bleeding of tracheal mucosa, inflammatory cell infiltration and serious shedding of epithelial cells; the lung bleeding and the blood stasis are obvious; bronchioles are blocked, the obstructions being mainly exfoliated epithelial cells, red blood cells, and exuded fibers and proteins. The diseased chicken developed more severe tissue damage with an inflammatory response.
According to the traditional Chinese medicine, the syndrome of phlegm-heat stagnating in the lung is formed because the lung qi is stagnated due to pathogenic factors, the body fluid cannot be distributed and stagnated to generate heat, and the fluid is gathered into phlegm; thereby forming a cheese-like mass that causes the chicken bronchial tubes to plug. At present, the prevention and treatment modes mostly adopt vaccines for immunizing and preventing influenza viruses and newcastle disease viruses, and the treatment stage mostly adopts heat-clearing and detoxifying traditional Chinese medicines such as tilmicosin preparation products or Shuanghuanglian oral liquid and the like. The vaccine is adopted for epidemic prevention, mainly aiming at respiratory virus diseases, and the virus is resisted by generating antibodies by an organism through early immunization, so that the vaccine belongs to prevention and cannot be used for treatment; the treatment effect of antibiotics such as tilmicosin is antibacterial and anti-inflammatory, has treatment effect on bronchitis, cannot promote the dissolution and absorption of secondary embolus of an organism, and has insignificant treatment effect on bronchial embolism; the heat-clearing and detoxifying traditional Chinese medicines such as Shuanghuanglian preparations lack the efficacy of dispersing lung qi and resolving phlegm, and are not good for dispersing lung qi and body fluid.
Disclosure of Invention
Through deep and detailed experiments, the inventor successfully develops the traditional Chinese medicine composition for preventing and treating the chicken bronchial embolism, has the effects of freeing lung, relieving asthma, clearing heat and reducing phlegm, and has good clinical prevention and treatment effects on the chicken bronchial embolism caused by cold, lung heat cough and asthma or other respiratory diseases. Compared with antibiotics, hormones and chemical synthetic drugs, the invention has no toxic or side effect, and is safe and reliable. The invention is realized by the following scheme:
the composition is prepared from the following raw materials in parts by weight: 2-6 parts of cassia twig, 1-5 parts of ephedra, 1-5 parts of bitter apricot kernel, 2-8 parts of dyers woad leaf, 1-6 parts of pummelo peel, 2-5 parts of liquorice and 1-15 parts of gypsum.
The composition is further prepared from the following raw materials in parts by weight: 3-6 parts of cassia twig, 2-4 parts of ephedra, 1-5 parts of bitter apricot kernel, 4-8 parts of dyers woad leaf, 3-6 parts of pummelo peel, 2-5 parts of liquorice and 1-15 parts of gypsum.
The composition is further prepared from the following raw materials in parts by weight according to a preferred proportion: 3-6 parts of cassia twig, 3 parts of ephedra, 3 parts of bitter apricot seed, 6-8 parts of dyers woad leaf, 5-6 parts of pummelo peel, 3 parts of liquorice and 10-15 parts of gypsum.
The composition is further prepared from the following raw materials in parts by weight: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 3 parts of liquorice and 15 parts of gypsum.
The composition can be prepared into various dosage forms, including oral liquid, powder, granules and the like.
The traditional Chinese medicine composition is used for preventing and treating the chicken bronchial embolism in the breeding process.
The traditional Chinese medicine composition is used for preventing and treating the chicken bronchial embolism by being matched with antibiotics such as tilmicosin, florfenicol and valnemulin in the breeding use.
The composition is applied to the prevention and treatment of the bronchial embolism diseases of the chickens caused by cold, lung heat cough and asthma or other respiratory diseases.
The traditional Chinese medicine composition for preventing and treating the chicken bronchial embolism has the following effects: ephedra herb has the effects of inducing sweat, relieving exterior syndrome, ventilating and smoothing lung, relieving asthma, inducing diuresis and reducing edema; cassia twig, ramulus cinnamomi, inducing sweat to relieve muscles, warming and activating meridians, supporting yang and regulating qi; bitter apricot seeds can relieve cough and asthma, moisten intestines and relax bowels; gypsum Fibrosum, which has effects in clearing away heat, purging pathogenic fire, relieving restlessness, quenching thirst, astringing, and promoting granulation; the liquorice has the effects of tonifying qi and strengthening middle warmer, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing drug properties; folium Isatidis has effects of clearing away heat and toxic materials, cooling blood, and removing speckle; hua Ju hong, regulate qi and relieve epigastric distention, dry dampness and resolve phlegm. The Chinese medicines are used together, and have the effects of dispersing lung qi, relieving asthma, clearing heat and eliminating phlegm; has good clinical prevention and treatment effect on the bronchial embolism of the chicken caused by cold, lung heat cough and asthma or other respiratory diseases.
The invention has the beneficial effects that:
1. the traditional Chinese medicines are organically combined to coordinate the organ functions, so that the death rate of the chicken caused by bronchial obstruction is reduced, and toxic and side effects are avoided.
2. The traditional Chinese medicine composition is screened out through a large number of tests, and compared with more than ten medicines of the traditional medicine composition, the prescription of the composition is more simplified, and the curative effect is better and outstanding.
3. After being used together, the traditional Chinese medicines in the traditional Chinese medicine composition have the effects of freeing lung, relieving asthma, clearing heat and reducing phlegm; has good clinical prevention and treatment effect on the bronchial embolism of the chicken caused by cold, lung heat cough and asthma or other respiratory diseases.
4. The traditional Chinese medicine composition has obvious clinical effect, no toxic or side effect, and is safe and reliable compared with antibiotics, hormones and chemically synthesized medicines.
5. The traditional Chinese medicine composition can be prepared into oral liquid, granules and powder for drinking water or mixing according to large-scale breeding habits.
6. The preparation method disclosed by the invention is simple in preparation process, convenient to use, low in price and environment-friendly, and raw materials are easy to obtain.
Detailed Description
The disclosure may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and the examples included therein. The present invention is further illustrated by the following examples, which should not be construed as limiting the scope of the present invention, and the insubstantial modifications and adaptations of the invention by those skilled in the art based on the teachings of the present invention as set forth above are intended to be covered by the present invention.
EXAMPLE 1 preparation of granules
1. The formula comprises the following components: 2 parts of cassia twig, 5 parts of ephedra herb, 2 parts of bitter apricot seed, 4 parts of dyers woad leaf, 2 parts of pummelo peel, 2.5 parts of gypsum and 4 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to a formula, adding 8 times of water, decocting for two times, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, keeping a slightly boiling state after boiling, combining and filtering liquid medicines obtained in two times, concentrating under reduced pressure and recovering to obtain thick paste with the relative density of 1.21-1.25 (55 ℃), adding 1 time of sugar powder and 3 times of dextrin into the thick paste, preparing into granules, drying and subpackaging to obtain the traditional Chinese medicine composition.
EXAMPLE 2 preparation of granules
1. The formula comprises the following components: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 15 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to the formula, decocting for three times, adding 8 times of water for the first time, and carrying out 2 hours; decocting for 1.5 hours in 6 times of water for the second time; decocting in 6 times of water for 1.0 hr for the third time. Keeping a slightly boiling state after each boiling, combining the extracted liquid medicine, filtering, concentrating under reduced pressure and recovering to obtain thick paste with the relative density of 1.10-1.20 (55 ℃), adding 3 times of lactose and 1 time of dextrin into the thick paste, preparing into granules, drying and subpackaging to obtain the traditional Chinese medicine.
EXAMPLE 3 preparation of powders
1. The formula comprises the following components: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 2 parts of dyers woad leaf, 3 parts of pummelo peel, 15 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to the formula, respectively crushing, sieving with a 40-mesh sieve, and uniformly mixing to obtain the traditional Chinese medicine composition.
EXAMPLE 4 preparation of powders
1. The formula comprises the following components: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 15 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to the formula, respectively crushing, sieving with a 40-mesh sieve, and uniformly mixing to obtain the traditional Chinese medicine composition.
EXAMPLE 5 preparation of powders
1. The formula comprises the following components: 4 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 5 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to a formula, adding 8 times of water, decocting for two times, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, keeping a slightly boiling state after boiling, mixing and filtering liquid medicines obtained in two times, concentrating under reduced pressure, recovering to obtain an extract with the relative density of 1.05-1.10 (55 ℃), performing spray drying, crushing, sieving by a 60-80-mesh sieve, and subpackaging to obtain the traditional Chinese medicine composition.
EXAMPLE 6 preparation of powders
1. The formula comprises the following components: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 15 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to a formula, adding 10 times of water, decocting for two times, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, keeping a slightly boiling state after boiling, mixing and filtering liquid medicines obtained in two times, concentrating under reduced pressure and recovering to obtain thick paste with the relative density of 1.10-1.20 (55 ℃), adding 3 times of lactose and 1 time of dextrin into the thick paste, drying, crushing, sieving with a 60-80-mesh sieve, and subpackaging to obtain the traditional Chinese medicine composition.
EXAMPLE 7 preparation of oral liquid
1. The formula comprises the following components: 6 parts of cassia twig, 1 part of ephedra herb, 2 parts of bitter apricot seed, 4 parts of dyers woad leaf, 6 parts of pummelo peel, 2 parts of gypsum and 2 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to a formula, adding 8 times of water, soaking for 1 hour, decocting for three times, decocting for 2 hours for the first time, decocting for 1.5 hours for the second time, and decocting for 1.0 hour for the third time; keeping a slightly boiling state after each boiling, uniformly mixing and filtering the liquid medicines for three times, concentrating and recovering under reduced pressure until the concentration of the solution is 1g/ml (each ml of the solution contains 1g of crude drug), refrigerating for 24 hours, filtering by a pulp board, complementing the loss amount, refrigerating for 24 hours, filtering, adding 3 per thousand of sodium benzoate and potassium sorbate, stirring for dissolving, sterilizing for 30 minutes by circulating steam, and filling to obtain the traditional Chinese medicine.
EXAMPLE 8 preparation of oral liquid
1. The formula comprises the following components: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 15 parts of gypsum and 3 parts of liquorice.
2. The preparation method comprises the following steps: weighing the traditional Chinese medicine composition according to a formula, adding water, and decocting for three times, wherein the first time is 6 times of water, the second time is 4 times of water, the first time is 1.5 hours, the second time is 1.0 hour, and the third time is 4 times of water, and the third time is 1.0 hour; and merging and filtering the three liquid medicines, concentrating under reduced pressure and recovering to the volume of the solution: the weight of the medicinal materials is 1: 3; refrigerating for 24 hr, filtering, adding 3 ‰ sodium benzoate and potassium sorbate, stirring to dissolve, adding purified water to obtain solution with concentration of 2.4g/ml (2.4 g crude drug per ml solution), bottling, and sterilizing.
Example 9 clinical trial 1
1 materials and methods
1.1 test materials
1.1.1 Chinese medicinal composition for preventing and treating chicken bronchial embolism: supplied by repulping (Tianjin) biopharmaceutical industries, Inc.
1.1.2 test subjects:
in a tobacco station and a certain meat chicken farm of mu ping, white feather meat chicken of 21 days old, 24000 chickens/house, 6 houses in total. The number of the sick chicken houses is 3, and the sick chicken houses are divided into 3 groups, wherein each group comprises 24000 chickens.
Clinical symptoms: respiratory symptoms, nose throwing, cough, snore; the mouth is opened and the neck is extended for strange calling; at first glance, fright and aversion to cold; the feed intake is reduced.
Symptoms of caesarean examination: the larynx and trachea of the dead chicken are congested and bleeding, some of the trachea has mucus, the bronchus has yellow embolism, the lung has foam or purple color, and the base of the lung has yellow cheese; the abdominal air sac appears turbid, thickened and yellow or yellowish white sticky matter; severe appearance of lung necrosis.
1.1.3 feed, feeding utensils and other supplies are provided by the farm.
1.1.4 recording articles and related test articles, provided by the subject group.
1.2 test methods
A medication stage: is used for treating after disease onset.
Experimental groups: hen house No. 2, 24000. The product of example 8 is taken every day, and 2ml of the product is mixed with 1L of water for continuous administration for 5 days.
Control group 1: no. 3 chicken house, 24000. Taking tilmicosin soluble powder (10%) every day, purchased from a certain manufacturer in Hebei; the preparation is administered by mixing 0.5g of the above medicinal materials with 1L of water for 5 days.
Control group 2: no. 4 hen house, 24000. The oral liquid of ephedra, apricot, stone and licorice is taken every day and purchased from a certain manufacturer in Hebei; the medicine is administered by mixing 2ml of 1L water for 5 days.
1.3 measurement indexes: the disease, spirit and disease of the test chicken are observed every day, the daily death and culling amount of each group is recorded, and the bronchus condition is observed by respectively performing a dissection before and after the test is started.
1.4 feeding conditions: the same nutrition standard, unified management system, unified feeding program and unified feeding environment are adopted, and the prevention and disinfection work is carried out according to the conventional method.
2, test results: see table 1 for details.
TABLE 1
Remarking: and C, performing autopsy on dead chickens, namely randomly extracting 20 dead chickens in each group and performing autopsy.
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The results show that the traditional Chinese medicine composition can effectively treat the chicken bronchial embolism; the single day mortality rate decreased by about 4-fold after treatment; no embolus exists in the trachea after the cesarean examination of the dead chicken.
The experimental group was compared with the control group 1 (tilmicosin soluble powder): tilmicosin can effectively sterilize and resist inflammation and has a treatment effect on respiratory tract and bronchitis; but has no effect on the absorption of secretions and emboli generated by inflammation; has single function. The treatment effect of the experimental group medicament on the chicken bronchial embolism is better than that of the control group 1 medicament.
The experimental group was compared with the control group 2 (Maxingshigan oral liquid): the experimental group medicament is mainly prepared by adding cassia twig on the basis of the formula of the ephedra, apricot kernel, gypsum and licorice oral liquid to enhance the effects of sweating, expelling pathogenic factors from muscles, warming and activating meridians and collaterals, and supporting yang and regulating qi; dyers woad leaf has the effects of clearing heat and removing toxicity, cooling blood and removing ecchymoses, and is especially good at clearing heat and entering nutrient blood, and warming toxicity and generating ecchymoses; exocarpium Citri Grandis has effects of regulating qi-flowing, relieving epigastric distention, eliminating dampness and phlegm, and promoting absorption and dissolution of inflammatory secretion and embolus. Based on the comparison of the formula theory and the clinical effect, the treatment effect of the experimental group medicament on the chicken bronchial embolism is better than that of the control group 2 medicament.
Example 10 clinical trial 2
1 materials and methods
1.1 test materials
1.1.1 Chinese medicinal composition for preventing and treating chicken bronchial embolism: supplied by repulping (Tianjin) biopharmaceutical industries, Inc.
1.1.2 test subjects:
in a certain broiler breeding farm in Liaoyuan city of Jilin province, 100000 white feather broilers are grown in 12 days.
Clinical symptoms: normal rearing, slight nasal flinching and occasional coughing after vaccination.
Symptoms of caesarean examination: the bronchus of the dead chicken has no embolus and a small amount of mucus substances.
1.1.3 feed, feeding utensils and other supplies are provided by chicken farms.
1.1.4 recording articles and related test articles, provided by the subject group.
1.2 test methods
A medication stage: it can be used for preventing diseases after immunization. The normal immune inactivated newcastle disease virus, infectious bronchitis virus, newcastle disease and infectious bronchitis of 7-day-old chickens are used for preventing the newcastle disease virus, infectious bronchitis virus, newcastle disease and infectious bronchitis of 12-day-old chickens in the peak risk period of chicken morbidity.
2 chickens in total are divided into 2 groups, and each group contains 100000 chickens.
Experimental groups: the product of example 2 is taken every day, and 1.5ml of water is added into the product for administration, and the administration lasts for 7 days.
Control group: the Shuanghuanglian oral liquid is taken every day, is purchased from a certain manufacturer of Beijing according to 1.5ml, is added with 1L of water for administration, and is continuously taken for 7 days.
1.3 measurement indexes: the state, spirit and other conditions of the test chickens were observed every day, the daily death and culling amount of each group was recorded, and the bronchus conditions were observed by performing a dissection before and after the start of the test.
1.4 feeding conditions: the same nutrition standard, unified management system, unified feeding program and unified feeding environment are adopted, and the prevention and disinfection work is carried out according to the conventional method.
2, test results: see table 2 for details.
TABLE 2
Remarking: and C, performing autopsy on dead chickens, namely randomly extracting 20 dead chickens in each group and performing autopsy.
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The results show that the traditional Chinese medicine composition can effectively prevent the chicken bronchial embolism; compared with the heat-clearing and detoxifying traditional Chinese medicine Shuanghuanglian oral liquid of a control group, the medicine composition of the experimental group has the effects of diffusing lung qi, relieving asthma and reducing phlegm; is beneficial to the absorption and dissolution of inflammatory secretion and reduces the formation of bronchial embolus. Based on the comparison of the formula theory and the clinical effect, the prevention effect of the experimental group medicament on the chicken bronchial embolism is better than that of the control group medicament.
Example 10 clinical trial 3
1 materials and methods
1.1 test materials
1.1.1 Chinese medicinal composition for preventing and treating chicken bronchial embolism: supplied by repulping (Tianjin) biopharmaceutical industries, Inc.
1.1.2 test subjects:
in a certain broiler breeding farm in the northern Yanshan of Hebei Cangzhou, 14-day-old white feather broilers are bred in 8000 per house, and the breeding farm is 4 houses in total. The number of the sick chicken houses is 3, and the sick chicken houses are divided into 3 groups, and each group comprises 8000 chickens.
Clinical symptoms: respiratory symptoms, cough, snore; the mouth is opened and the neck is extended for strange calling; redness and swelling of the eyelids; hair at first sight; the feed intake is reduced.
Symptoms of caesarean examination: the larynx and trachea of the dead chicken are congested and bleeding, some of the trachea has mucus, the bronchus has yellow embolism, the lung has foam and purple color, and the base of the lung has yellow cheese; severe lung necrosis occurred.
1.1.3 feed, feeding utensils and other supplies are provided by the farm.
1.1.4 recording articles and related test articles, provided by the subject group.
1.2 test methods
A medication stage: is used for treating after disease onset.
Experimental groups: number 2 chicken coop, 8000. The product of example 6 is taken every day, and 2ml of the product is added with 1L of water for continuous administration for 5 days; the tilmicosin soluble powder (10%) (produced by Risper (Tianjin) biological medicine industry Co., Ltd.) is administered together with water of 0.5g and 1L for 5 days.
Control group 1: number 3 chicken coop, 8000. Taking tilmicosin soluble powder (10%) every day, produced by rapu (Tianjin) biological medicine industry Co., Ltd; the preparation is administered by mixing 0.5g of the above medicinal materials with 1L of water for 5 days.
Control group 2: number 4 chicken coop, 8000. The product of example 6 is taken every day, and 2ml of the product is mixed with 1L of water for continuous administration for 5 days.
1.3 measurement indexes: the disease, spirit and disease of the test chicken are observed every day, the daily death and culling amount of each group is recorded, and the bronchus condition is observed by respectively performing a dissection before and after the test is started.
1.4 feeding conditions: the same nutrition standard, unified management system, unified feeding program and unified feeding environment are adopted, and the prevention and disinfection work is carried out according to the conventional method.
2, test results: see table 3 for details.
TABLE 3
Remarking: c, performing necropsy on dead chickens, namely randomly extracting 20 dead chickens in each group and performing the necropsy; less than 20, all necropsies.
3 small knot
The results show that the traditional Chinese medicine composition can effectively treat the chicken bronchial embolism by being matched with the tilmicosin soluble powder; the single day mortality rate decreased by about 6-fold after treatment; no embolus exists in the trachea after the cesarean examination of the dead chicken.
Tilmicosin can effectively sterilize and resist inflammation and has a treatment effect on respiratory tract and bronchitis; the Chinese medicinal composition has good absorption effect on secretion and embolus generated by inflammation. The experimental group adopts the combination of the traditional Chinese medicine composition and the tilmicosin soluble powder for treatment; on the basis of eliminating respiratory tract inflammation, the spreading and absorption of secondary inflammation secretion are further enhanced, and the formation of embolism is effectively reduced. Compared with the control group 1, the control group can effectively reduce the death and elutriation amount and the occurrence of bronchial embolism in the same day; compared with the control group 2, the composition effectively reduces the death and elutriation amount of the patient in the same day, and further improves the treatment of the bronchial embolism.
Claims (4)
1. A traditional Chinese medicine composition for preventing and treating chicken bronchial embolism is characterized in that: the composition is prepared from the following raw materials in parts by weight: 6 parts of cassia twig, 3 parts of ephedra herb, 3 parts of bitter apricot seed, 8 parts of dyers woad leaf, 5 parts of pummelo peel, 3 parts of liquorice and 15 parts of gypsum.
2. The traditional Chinese medicine composition for preventing and treating chicken bronchial embolism according to claim 1, which is characterized in that: the composition can be prepared into oral liquid, powder and granules.
3. The use of the traditional Chinese medicine composition for preventing and treating the chicken bronchial embolism according to claim 1 in the breeding use for preparing a medicine for preventing and treating the chicken bronchial embolism.
4. The traditional Chinese medicine composition for preventing and treating chicken bronchial embolism according to claim 1, which is characterized in that: the traditional Chinese medicine composition is used in a breeding mode and is matched with tilmicosin, florfenicol and valnemulin to prepare a medicine for preventing and treating the chicken bronchial embolism.
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