CN116832091B - Traditional Chinese medicine composition for treating poultry bronchial embolism, preparation and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating poultry bronchial embolism, preparation and preparation method and application thereof Download PDFInfo
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- CN116832091B CN116832091B CN202311060692.4A CN202311060692A CN116832091B CN 116832091 B CN116832091 B CN 116832091B CN 202311060692 A CN202311060692 A CN 202311060692A CN 116832091 B CN116832091 B CN 116832091B
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to the field of traditional Chinese veterinary medicines, and in particular discloses a traditional Chinese medicine composition for treating poultry bronchial embolism, a preparation thereof, a preparation method and application. The traditional Chinese medicine composition comprises the following raw material components in parts by weight: 10-30 parts of wild buckwheat rhizome, 5-15 parts of honeysuckle, 5-15 parts of hairyvein agrimony, 4-12 parts of bitter apricot seed, 4-12 parts of snakegourd fruit, 2-6 parts of borneol and 1-5 parts of liquorice. The traditional Chinese medicine preparation for treating the poultry bronchial embolism is prepared by combining and matching the medicines, has the advantages of refined formula, obvious curative effect and proper cost, and has good treatment effect on the bronchial embolism caused by exogenous wind-heat, epidemic and wind-cold evil entering the interior depression to transform heat and the like of the poultry. The invention effectively solves the problem of the prior art that the clinical application effect of the veterinary drug preparation for treating the poultry bronchial embolism is not ideal.
Description
Technical Field
The invention relates to the field of traditional Chinese veterinary medicines, and in particular discloses a traditional Chinese medicine composition for treating poultry bronchial embolism, a preparation thereof, a preparation method and application.
Background
The poultry raising environment is generally a closed environment, particularly in winter and spring, the environment is not dared to ventilate for heat preservation, air is dirty, respiratory tract infection is easily caused, a great amount of sputum is visible in the air tube of the poultry dying of the disease during the section inspection, and the bronchus is blocked by yellow-white cheese-like objects. The poultry bronchi embolism has high morbidity, high mortality and long disease course, and has great harm to the poultry industry.
Major clinical symptoms and pathological changes of poultry bronchial embolism: the feed intake is reduced, the spirit is low, the breathing is difficult, the neck is widened, the strange is called, the dead birds mostly have the bellyband upwards, and the two legs are curled. The sectioning and examination mainly show that a great deal of sputum exists in the respiratory tract, sticky sputum or yellow-white cheese sample exists in the trachea, the bronchus is blocked by the yellow-white cheese sample, and the lung is engorged by blood, bleeding and blackening.
The pathogenesis of the bronchi embolism of poultry is mainly: the body feels exogenous evil (pestilence, wind heat), heat evil attacks the lung, or wind-cold, stagnation and heat transformation, high fever and drowsiness; the heat toxin is accumulated in the lung, and the lung is suppuratively formed into an ulcer, so that lung carbuncle, cough and vomiting of purulent phlegm and yellow phlegm are formed; burning body fluids, burning body fluids into phlegm, phlegm-heat obstructing the lung, no descending of lung qi, cough and dyspnea, long-time stagnation of phlegm-heat, sticky phlegm, forming phlegm nuclei, and obstruction of trachea, and dyspnea; in addition, heat forces blood to flow out of blood vessels, which leads to bleeding in lung and trachea, and blood and sputum are mixed to form blood-sputum.
At present, antibiotics such as macrolides, tetracyclines and the like are commonly used for clinically treating the bronchiolembolism of poultry, and respiratory tract exterior-syndrome-relieving medicines are used as auxiliary medicines, and some schemes are used for compounding traditional Chinese veterinary medicines, wherein the common traditional Chinese veterinary medicines comprise Maxingshi Ganma oral liquid and Shuanghuanglian oral liquid. The Ma xing shigan oral liquid has relatively weak effects of cooling blood, stopping bleeding, resolving phlegm, inducing resuscitation and restoring consciousness, and has poor curative effect on controlling dyspnea and death caused by bronchial hemorrhage and bronchial embolism; the Shuanghuanglian oral liquid pays attention to clearing heat, but has shortages in relieving cough, relieving asthma, reducing phlegm, cooling blood, stopping bleeding, inducing resuscitation and restoring consciousness, so the clinical application effect is not ideal, and therefore, the research and development of the traditional Chinese medicine preparation capable of effectively treating the bronchus embolism of poultry has great practical significance for poultry raising.
Disclosure of Invention
Aiming at the problem of the prior art that the clinical application effect of a traditional Chinese veterinary medicine preparation for treating the poultry bronchial embolism is not ideal, the invention provides a traditional Chinese medicine composition for treating the poultry bronchial embolism, a preparation and a preparation method and application thereof.
In order to achieve the above purpose, the present invention provides the following technical solutions:
The invention provides a traditional Chinese medicine composition for treating poultry bronchial embolism, which comprises the following raw material components in parts by weight: 10-30 parts of wild buckwheat rhizome, 5-15 parts of honeysuckle, 5-15 parts of hairyvein agrimony, 4-12 parts of bitter apricot seed, 4-12 parts of snakegourd fruit, 2-6 parts of borneol and 1-5 parts of liquorice.
Compared with the prior art, the invention provides a traditional Chinese medicine composition for treating the bronchi embolism of poultry, which selects traditional Chinese medicines with the effects of clearing heat, ventilating lung, resolving phlegm, relieving cough, cooling blood, stopping bleeding, eliminating carbuncles, expelling pus and restoring consciousness to be combined by screening the traditional Chinese medicines. Wherein, the wild buckwheat rhizome, the honeysuckle and the hairyvein agrimony are monarch drugs, the bitter apricot seed and the snakegourd fruit are ministerial drugs, the borneol is adjuvant drug, and the liquorice is conductant drug.
The wild buckwheat rhizome has slightly pungent and astringent taste, is cool in nature, enters lung meridian, and has the effects of clearing heat and detoxicating, clearing lung and expelling pus, and activating blood and removing stasis; honeysuckle flower is sweet in taste and cold in nature, enters lung, heart and stomach meridians, and has the effects of clearing heat and detoxicating and dispelling wind and heat; herba et Gemma Agrimoniae has bitter and astringent taste, is mild in nature, and can astringe to stop bleeding, stop dysentery and detoxify after being used for heart, lung and liver channels; bitter apricot kernel has bitter taste and slightly warm nature, enters lung and large intestine channels, and has the effects of reducing qi, relieving cough and asthma, and relaxing bowel; fructus Trichosanthis is has sweet taste, slightly bitter taste, cold property, and can enter lung, stomach and large intestine channels, clear heat and remove phlegm, relieve chest stuffiness and dissipate stagnation, moisten dryness and smooth intestine; the borneol has faint scent, pungent and bitter taste, cool nature, and heart, spleen and lung channels, and has the effects of inducing resuscitation, refreshing mind, clearing heat and relieving pain; licorice is sweet in taste and mild in nature, enters twelve meridians, and has the effects of tonifying middle-jiao and Qi, eliminating phlegm and relieving cough, regulating middle-jiao and relieving urgency, detoxifying and harmonizing drug property.
The composition for treating the poultry bronchial embolism has the effects of clearing lung-heat, purging heat, cooling blood, stopping bleeding, relieving cough and asthma, resolving phlegm, resolving carbuncles, expelling pus, and restoring consciousness and inducing resuscitation, has obvious curative effect and proper cost compared with the large compound medicine in the prior art, and has good treatment effect on the bronchial embolism caused by exogenous wind-heat, epidemic pestilence, wind-cold invasion of internal depression and heat formation of poultry and the like.
Preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 15-30 parts of wild buckwheat rhizome, 8-15 parts of honeysuckle, 8-12 parts of hairyvein agrimony, 6-12 parts of bitter apricot seed, 6-10 parts of snakegourd fruit, 3-6 parts of borneol and 2-4 parts of liquorice.
Further preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 20-30 parts of wild buckwheat rhizome, 10-15 parts of honeysuckle, 10-12 parts of hairyvein agrimony, 8-10 parts of bitter apricot seed, 6-10 parts of snakegourd fruit, 3-6 parts of borneol and 3 parts of liquorice.
Further preferably, the traditional Chinese medicine composition comprises the following raw material components in parts by weight: 25 parts of wild buckwheat rhizome, 10 parts of honeysuckle, 10 parts of hairyvein agrimony, 8 parts of bitter apricot seed, 8 parts of snakegourd fruit, 6 parts of borneol and 3 parts of liquorice.
The second aspect of the invention provides a traditional Chinese medicine preparation for treating the poultry bronchial embolism, which comprises the traditional Chinese medicine composition for treating the poultry bronchial embolism.
Preferably, the dosage form is any one of oral liquid or granules.
The Chinese medicinal preparation can be prepared into oral medicaments and granules according to the medicament characteristics of large-scale cultivation, and can be used for mixing materials or drinking water.
The third aspect of the invention provides a preparation method of the traditional Chinese medicine preparation for treating the poultry bronchial embolism, which comprises the following steps:
firstly, weighing components except the deicer slices according to a designed proportion, adding water for decoction for 2-3 times, filtering, concentrating under reduced pressure until the relative density of liquid is 1.02-1.06, and cooling to obtain concentrated solution;
Dissolving borneol in alcohol to obtain a borneol alcohol solution; adding emulsifier into the borneol solution, and uniformly mixing to obtain borneol mixed solution;
And thirdly, uniformly mixing the concentrated solution with the borneol mixed solution, adding a preservative, adding water to ensure that the liquid medicine ratio is 0.9-1:1-1.1, and sterilizing at 120-122 ℃ to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
Preferably, in the first step, the water adding amount is 8-14 times of the medicine mass.
Preferably, in the first step, the specific operation of the decoction is keeping micro-boiling for 30min-90min after boiling.
Preferably, in the second step, the mass ratio of the borneol to the alcohol is 1:10-30.
Preferably, in the second step, the alcohol is ethanol with the mass concentration of 90% -95%.
Preferably, in the second step, the emulsifier is tween 80.
Preferably, in the second step, the mass ratio of the emulsifier to the borneol solution is 1-3:100.
Preferably, in the third step, the preservative is one or two of sodium benzoate and ethylparaben.
Preferably, in the third step, the addition amount of the preservative is 0.5-0.6 wt% of the total amount of the concentrated solution and the borneol mixed solution.
Preferably, in the third step, the sterilization time is 15min-20min.
The fourth aspect of the invention provides a preparation method of the traditional Chinese medicine preparation for treating the poultry bronchial embolism, which comprises the following steps:
S1, weighing components except the ice flakes according to a designed proportion, adding water for decocting for 2-3 times, filtering, concentrating under reduced pressure, sampling, cooling the sample to 60-65 ℃ for measuring the relative density, stopping concentrating under reduced pressure when the relative density is 1.08-1.25, and cooling to obtain concentrated extract;
s2, weighing auxiliary materials, adding the concentrated extract, uniformly mixing, granulating and drying to obtain granules;
S3, dissolving borneol in alcohol, spraying the borneol on the surfaces of the particles, and drying to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
Preferably, in S2, the auxiliary materials are powdered sugar and dextrin with a mass ratio of 3-10:1.
Preferably, in S2, the dosage of the auxiliary materials is 3-6 times of that of the concentrated extract.
Aiming at the problem of the prior art that the clinical application effect of the traditional Chinese veterinary medicine preparation for treating the poultry bronchial embolism is not ideal, the invention provides a traditional Chinese medicine composition and a preparation for treating the poultry bronchial embolism. The invention takes wild buckwheat rhizome, honeysuckle, hairyvein agrimony, bitter apricot seed, snakegourd fruit, borneol and liquorice as raw materials, and the medicines are combined and matched according to the monarch, minister, assistant and guide relationship of the medicines to be applied to the bronchus embolism of poultry. The traditional Chinese medicine composition for treating the poultry bronchial embolism provided by the invention has the advantages of refined formula, lung heat clearing, heat purging, blood cooling, hemostasis, cough and asthma relieving, phlegm resolving, carbuncle eliminating, pus expelling, brain refreshing and resuscitation inducing effects, and has a remarkable curative effect and proper cost compared with the large compound medicines in the prior art, and has a good treatment effect on the poultry bronchial embolism caused by exogenous wind-heat, pestilence, wind-cold invasion into interior depression, heat transformation and the like.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
The embodiment provides a traditional Chinese medicine composition and a preparation for treating poultry bronchial embolism, which specifically comprise the following contents:
the traditional Chinese medicine composition for treating the poultry bronchial embolism comprises the following raw material components in parts by weight: 25 parts of wild buckwheat rhizome, 10 parts of honeysuckle, 10 parts of hairyvein agrimony, 8 parts of bitter apricot seed, 8 parts of snakegourd fruit, 6 parts of borneol and 3 parts of liquorice;
the preparation method of the traditional Chinese medicine preparation for treating the poultry bronchial embolism comprises the following steps:
Firstly, weighing components except for ice flakes according to a designed proportion, adding water with the amount of 14 times that of the drug, boiling, continuously keeping micro-boiling, decocting for 60 minutes, adding water with the amount of 10 times that of the drug, boiling, continuously keeping micro-boiling, decocting for 30 minutes, filtering by adopting a filter cloth with 100 meshes after decocting, concentrating the filtrate under reduced pressure to the relative density of 1.05 of the liquid medicine, and cooling to room temperature to obtain concentrated solution;
Dissolving borneol in 95% ethanol according to a mass ratio of 1:10, adding tween 80 accounting for 2% of the mass of the borneol solution, and uniformly mixing to obtain borneol mixed solution;
And thirdly, uniformly mixing the concentrated solution with the borneol mixed solution, adding sodium benzoate accounting for 0.5 weight percent and ethylparaben accounting for 0.05 weight percent of the total weight of the concentrated solution and the borneol mixed solution, adding purified water to a volume ratio of 1:1, and sterilizing for 15min at 121 ℃ to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
Example 2
The embodiment provides a traditional Chinese medicine composition and a preparation for treating poultry bronchial embolism, which specifically comprise the following contents:
the traditional Chinese medicine composition for treating the poultry bronchial embolism comprises the following raw material components in parts by weight: 25 parts of wild buckwheat rhizome, 10 parts of honeysuckle, 10 parts of hairyvein agrimony, 8 parts of bitter apricot seed, 8 parts of snakegourd fruit, 6 parts of borneol and 3 parts of liquorice;
the preparation method of the traditional Chinese medicine preparation for treating the poultry bronchial embolism comprises the following steps:
S1, weighing components except ice flakes according to a designed proportion, adding water with the amount of 14 times that of the components, boiling, continuously keeping micro-boiling, decocting for 60 minutes, adding water with the amount of 10 times that of the components, boiling, continuously keeping micro-boiling, decocting for 30 minutes, filtering by adopting a filter cloth with 100 meshes, concentrating the filtrate under reduced pressure, sampling, cooling the sample to 60 ℃ to determine the relative density, stopping concentrating under reduced pressure when the relative density is 1.15, and cooling to obtain concentrated extract;
S2, weighing 3 times of sugar powder and 1 time of dextrin in the concentrated extract, adding the concentrated extract while stirring, stirring until the concentrated extract is slightly held into a cluster, slightly pinching to obtain a powder, granulating by a 14-mesh sieve, and drying to obtain particles;
S3, dissolving borneol in 95% ethanol according to a mass ratio of 1:10, spraying the borneol on the surfaces of the particles, and drying to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
Example 3
The embodiment provides a traditional Chinese medicine composition and a preparation for treating poultry bronchial embolism, which specifically comprise the following contents:
The traditional Chinese medicine composition for treating the poultry bronchial embolism comprises the following raw material components in parts by weight: 10 parts of wild buckwheat rhizome, 10 parts of honeysuckle, 5 parts of hairyvein agrimony, 8 parts of bitter apricot seed, 8 parts of snakegourd fruit, 6 parts of borneol and 3 parts of liquorice;
the preparation method of the traditional Chinese medicine preparation for treating the poultry bronchial embolism comprises the following steps:
Firstly, weighing components except for the ice flakes according to a designed proportion, adding water with the amount of 12 times of that of the medicine, boiling, continuously keeping micro-boiling, decocting for 90 minutes, adding water with the amount of 10 times of that of the medicine, boiling, continuously keeping micro-boiling, decocting for 60 minutes, filtering by adopting a filter cloth with 100 meshes, concentrating the filtrate under reduced pressure until the relative density of the liquid medicine is 1.04, and cooling to room temperature to obtain concentrated solution;
Dissolving borneol in 95% ethanol according to a mass ratio of 1:10, adding tween 80 accounting for 2% of the mass of the borneol solution, and uniformly mixing to obtain borneol mixed solution;
And thirdly, adding sodium benzoate accounting for 0.45 weight percent and ethylparaben accounting for 0.06 weight percent of the total amount of the concentrated solution and the borneol mixed solution, adding purified water to a constant volume to a liquid medicine ratio of 1:1.05, and sterilizing at 121 ℃ for 20min to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
Comparative example 1
The comparison example provides a traditional Chinese medicine composition and a preparation for treating the bronchi embolism of poultry, which are different from the example 1 in that the wild buckwheat is replaced by the same amount of honey aster, the hairyvein agrimony is replaced by the same amount of cogongrass rhizome, and other components and preparation methods are unchanged and are not repeated here.
Comparative example 2
The comparison example provides a traditional Chinese medicine composition and a preparation for treating the bronchus embolism of poultry, which are different from the example 1 in that wild buckwheat is replaced by an equivalent houttuynia cordata, the bitter almond is replaced by an equivalent honey loquat leaf, and other components and preparation methods are unchanged and are not repeated here.
In order to further illustrate the technical effects of the invention, the invention performs a test of the treatment of the bronchus embolism of the poultry, and the specific contents are as follows:
1. Accurate treatment test of small group
Test animals: 24-day-old AA white feather broiler fed by Liaoning Dalian broiler farm.
Symptoms: snoring, neck stretching, mouth opening and gasping (abdominal breathing), strange and yellow brown feces appear in the large group, and the feces are thinner; the feed intake is reduced, and the chicken which looks healthy suddenly gets sharp and then dies supine.
Pathological section inspection: the method comprises the steps of sectioning and examining the trachea congestion and bleeding of a dead chicken, white sticky phlegm in the trachea, severe hemorrhagic phlegm, yellow-white cheese-like embolism in the lower end of the trachea to the bronchus, pulmonary congestion, blackening, pulmonary edema, individual yellow-white block-like objects, turbid chest and abdomen air sac, thickening, foam-like cellulose exudation, and yellow cheese-like object adhesion of the severe air sac.
Test grouping: and selecting 350 feathers of broilers with obvious and similar symptoms of the bronchial embolism from the sick chicken groups, and dividing the 350 feathers into a test group, a test group II, a test group III, a test group IV, a test group five, a test group six and a control group, wherein 50 broilers are fed with the same feed, and the other broilers are fed with the same feed except for different medicines.
Test drug: the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 2 of the invention, 10% doxycycline hydrochloride soluble powder, ephedra, apricot kernel, lycoris radiata and coptis root oral liquid, wherein the medicines are produced by the pharmaceutical company of northward fight Yu.
Test treatment:
Test group: according to 1mL:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Test two groups: according to 1g:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the embodiment 2 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
three groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 1L of Maxingshi Ganman oral liquid is added into the mixture, and the mixture is uniformly mixed, and the mixture is used for drinking water for sick chickens for 5 days;
Four groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 1L of Shuanghuanglian oral liquid is added, mixed uniformly and used for drinking water for sick chickens for 5 days;
test five groups: according to 1ml:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the comparative example 1 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Six groups were tested: according to 1ml:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the comparative example 2 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Control group: is not administered.
General symptomatic observation: during the test period, the disease development condition of each group of test chickens is recorded, and the mental state, appetite, respiration condition and the like of the sick chickens are observed.
Evaluation of curative effect: and immediately performing a section inspection on the dead chickens, judging that the typical pathological change feature appears as death of the disease, counting the number of dead chickens in each group in the whole test period, and calculating the death rate. When the test is finished, each group of surviving chickens is cut, the pathological changes of the viscera are observed, the cure number, the effective number and the ineffective number are counted, and the cure rate, the effective rate and the ineffective rate are calculated.
And (3) curing: after administration, the spirit, feeding and drinking water are basically recovered to be normal, the symptoms of the respiratory tract disappear, and the bronchus and the lung are examined by the section and no cheese-like embolism is detected to be cured.
The method is effective: after administration, the spirit, feeding and drinking water are obviously improved, the respiratory symptoms are relieved or eliminated, and the pathological changes such as slight congestion, bleeding, inflammatory exudates and the like of the bronchus and the lung are still detected by the section, but no obvious cheese-like embolism is judged to be effective.
Invalidation: after administration, symptoms are not improved and even dead, and the analysis of bronchi and lungs still has a large amount of cheese-like emboli.
The test results are as follows:
General symptomatic observation: the number of listlessness of the first, second, third, fourth, fifth and sixth groups is obviously reduced in 4-48 hours compared with the control group after administration, and the specific data are shown in table 1; the number of the suction barriers of the test group I, the test group II, the test group III, the test group four, the test group five and the test group six after the administration is obviously reduced in 4-48 hours compared with the control group, and the specific data are shown in the table 2; the feed intake of the first test group and the second test group after the administration gradually rises after 24 hours and returns to normal after 48 hours; the feed intake of the three, four, five and six groups tested after dosing was gradually increased after 24 hours, approaching 80% of the normal feed intake after 48 hours.
Evaluation of curative effect: after administration, the cure rates of the test group I, the test group II, the test group III, the test group four, the test group five and the test group six are obviously higher than those of the control group, and the cure rates of the test group I, the test group II are better than those of the test group three, the test group four, the test group five and the test group six; the test one, test two, test three, test four, test five and test six groups were significantly less inefficient and mortality than the control group, test one, test two were less than test three, test four, test five and test six groups, and the specific data are shown in table 3.
Table 1 mental states of chickens in each test group
Table 2 respiratory status of chickens in each test group
TABLE 3 evaluation of efficacy
2. Large group treatment trial
Test animals: 24-day-old AA white feather broiler fed by Liaoning Dalian broiler farm.
Symptoms: snoring, neck stretching, mouth opening and gasping (abdominal breathing), strange and yellow brown feces appear in the large group, and the feces are thinner; the feed intake is reduced, and the chicken which looks healthy suddenly gets sharp and then dies supine.
Pathological section inspection: the method comprises the steps of sectioning and examining the trachea congestion and bleeding of a dead chicken, white sticky phlegm in the trachea, severe hemorrhagic phlegm, yellow-white cheese-like embolism in the lower end of the trachea to the bronchus, pulmonary congestion, blackening, pulmonary edema, individual yellow-white block-like objects, turbid chest and abdomen air sac, thickening, foam-like cellulose exudation, and yellow cheese-like object adhesion of the severe air sac.
Test grouping: the chicken house with the disease is divided into 6 groups of 1 chicken, about 32000 chickens are fed with the same feed, and other feeding management is the same except for different medicines.
Test drug: the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 2 of the invention, 10% doxycycline hydrochloride soluble powder, ephedra, apricot kernel, lycoris radiata and coptis root oral liquid, wherein the medicines are produced by the pharmaceutical company of northward fight Yu.
Test treatment:
Test group: according to 1mL:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Test two groups: according to 1g:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the embodiment 2 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
three groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 1L of Maxingshi Ganman oral liquid is added into the mixture, and the mixture is uniformly mixed, and the mixture is used for drinking water for sick chickens for 5 days;
Four groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 1L of Shuanghuanglian oral liquid is added, and the mixture is uniformly mixed, and the mixture is used for drinking water for sick chickens for 5 days.
Test five groups: according to 1ml:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the comparative example 1 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Six groups were tested: according to 1ml:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 2 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days.
Test index: and observing conditions of appetite, disease development and the like of each group of test chickens every day, recording daily death and panning quantity of each group, and performing sectional inspection before and after the test, wherein the sectional inspection of the sick and dead chickens is to randomly extract 20 daily death chickens for sectional inspection, and observing respiratory tract recovery conditions.
Test results: specifically, the results are shown in Table 4.
TABLE 4 Large group treatment test results
As can be seen from table 4, the treatment effect of the group of tests (the traditional Chinese medicine oral liquid for treating the bronchi embolism provided by the embodiment 1 of the invention) and the group of tests (the traditional Chinese medicine granule for treating the bronchi embolism provided by the embodiment 2 of the invention) on the bronchi embolism of the chickens is remarkable, the respiratory tract symptoms after treatment are obviously reduced, the bronchi are free from embolism, the death and panning amount in a single day are obviously reduced, and the oral liquid and the granule are not obviously different; the treatment effect is better than the combination of antibiotics and Ma xing Shigan oral liquid, the combination of antibiotics and Shuanghuanglian oral liquid and the comparative example.
In order to further explore the best use effect of the traditional Chinese medicine preparation provided by the invention, the invention also carries out the following tests:
3. Effect test 1
Test animals: anhui certain Muscovy Duck farm, 35 days old Muscovy Duck.
Symptoms: slight respiratory symptoms do not pay attention to timely treatment, so that the later stage of the disease causes reduced feed intake, listlessness, zhang Koushen neck gasping and strangeness, and finally death due to asphyxia.
Pathological section inspection: the dead duck trachea and bronchus wall is engorged with blood and bleeding, and has yellow cheese-like blockage, blackening and oedema of lung, turbid air sac and thickening.
Test grouping: the duck shed with disease is divided into 5 groups of 1 according to the duck shed, and about 3000 of each group. Each group is fed with the same feed, and other groups are fed with the same feed except for different medicines.
Test drug: the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 2 of the invention, 10% tilmicosin soluble powder and ephedra, apricot kernel and lycopin oral liquid are all produced by pharmaceutical company of northward fight Yu.
Test treatment:
Test group: according to 1g:1kg of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention is uniformly mixed in the feed, and the feed is continuously fed for 5 days;
Test two groups: according to 1g: uniformly mixing 10% tilmicosin soluble powder in 1kg of feed, and continuously feeding for 5 days; simultaneously according to 1mL:1L of the ephedra, apricot, gypsum and licorice oral liquid is dissolved in water, and the oral liquid is drunk continuously for 5 days;
three groups were tested: according to 1g:1kg of 10% tilmicosin soluble powder and the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention are uniformly mixed in the feed in a ratio of 1kg, and are continuously fed for 5 days;
four groups were tested: according to 1g: uniformly mixing 10% tilmicosin soluble powder in 1kg of feed, and continuously feeding for 5 days; simultaneously according to 1mL:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided in the comparative example 1 is dissolved in water and drunk continuously for 5 days;
test five groups: according to 1g: uniformly mixing 10% tilmicosin soluble powder in 1kg of feed, and continuously feeding for 5 days; simultaneously according to 1mL:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided in the comparative example 2 is dissolved in water and drunk continuously for 5 days.
Test index: the mental and disease development conditions of the test ducks are observed every day, the daily death and panning amount of each group is recorded, the test ducks are respectively split before and after the start of the test, all the dead ducks are split, and the bronchus conditions are observed, and the specific results are shown in table 5.
TABLE 5 test results 1
The results show that the three groups (the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 and the tilmicosin soluble powder are matched for application) have obvious effect of treating the duck bronchial embolism, and the effects of reducing the mortality and the bronchial embolism rate are superior to those of other test groups, so that the combined effect of the invention and antibiotics is better.
4. Effect test 2
Test animals: shandong Liaocheng a farm, 28-day old 817 broilers.
Symptoms: dyspnea, strange feeling, nose throwing, listlessness, and no increase in food intake.
Pathological section inspection: the bronchioles of the dead chickens are blocked by yellow cheese-like substances, and the respective chicken bronchioles have bloody foam, pulmonary edema, redness, blackening, turbid air sac and thickening, and the respective dead chicken duodenal lymph nodes have bleeding.
Test grouping: the sick chickens are divided into 7 groups according to the chicken house, each group is 1 group, and each group is about 50000 chickens. Each group is fed with the same feed, and other groups are fed with the same feed except for different medicines.
Test drug: the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 2 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 1 of the invention, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the comparative example 2 of the invention, 10% doxycycline hydrochloride soluble powder and ephedra, apricot and lycopin oral liquid are produced by He northward fight Yu pharmaceutical Co.
Test treatment:
Test group: according to 1mL:2L of the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment 1 of the invention is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Test two groups: according to 1g:2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the embodiment 2 is dissolved in water, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
three groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water according to the following ratio of 1g:1L of Maxingshi Ganman oral liquid is added into the mixture, and the mixture is uniformly mixed, and the mixture is used for drinking water for sick chickens for 5 days;
Four groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the embodiment 1 is added into the mixture in proportion, and the mixture is uniformly mixed, and is used for drinking water for sick chickens for 5 days;
Test five groups: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water according to the following ratio of 1g:2L of the traditional Chinese medicine preparation for treating the bronchus embolism provided by the embodiment 2 is added in proportion, and is fully dissolved, and the traditional Chinese medicine preparation is used for drinking water for sick chickens for 5 days;
Six groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 2L of the traditional Chinese medicine preparation for treating the poultry bronchi embolism provided by the comparative example 1 is added into the mixture in proportion, and the mixture is uniformly mixed, and is used for drinking water for sick chickens for 5 days;
seven groups were tested: according to 1g:1L of 10% doxycycline hydrochloride soluble powder is dissolved in water, and 1ml of the solution is used for preparing the doxycycline hydrochloride powder: 2L of the traditional Chinese medicine preparation for treating the bronchial embolism provided by the comparative example 2 is added into the mixture in proportion, and the mixture is uniformly mixed, and is used for drinking water for sick chickens for 5 days.
Test index: and (3) observing the conditions of feeding, spirit, disease development and the like of the test chickens every day, recording the daily death and panning quantity of each group, performing section inspection before and after the test, randomly extracting 20 sick and dead chickens for section inspection, performing section inspection on all less than 20 sick and dead chickens, and observing the respiratory tract recovery condition.
Test results: as shown in table 6.
TABLE 6 test results 2
According to Table 6, the traditional Chinese medicine preparation for treating the poultry bronchial embolism provided by the embodiment of the invention has obvious effect of treating the chicken bronchial embolism by being singly used or matched with doxycycline, has obviously reduced mortality and bronchial embolism rate, and has good feed intake and mental state recovery. The application of the doxycycline is obviously superior to other test groups, because the doxycycline has the effects of resisting bacteria and mycoplasma, the traditional Chinese medicine preparation has the effects of clearing heat, ventilating lung, resolving phlegm, relieving cough, cooling blood, stopping bleeding, resolving carbuncles, expelling pus, and restoring consciousness and inducing resuscitation, and has a synergistic effect.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, or alternatives falling within the spirit and principles of the invention.
Claims (9)
1. A traditional Chinese medicine composition for treating poultry bronchial embolism is characterized in that: the composite material comprises the following raw material components in parts by weight: 15-30 parts of wild buckwheat rhizome, 8-15 parts of honeysuckle, 8-12 parts of hairyvein agrimony, 6-12 parts of bitter apricot seed, 6-10 parts of snakegourd fruit, 3-6 parts of borneol and 2-4 parts of liquorice.
2. A traditional Chinese medicine preparation for treating poultry bronchial embolism is characterized in that: the main component of the traditional Chinese medicine composition for treating the poultry bronchial embolism is the traditional Chinese medicine composition for treating the poultry bronchial embolism according to claim 1.
3. A traditional Chinese medicine preparation for treating poultry bronchial embolism as claimed in claim 2, characterized in that: the preparation formulation is any one of oral liquid or granules.
4. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 2, which is characterized in that: the method comprises the following steps:
firstly, weighing components except the deicer slices according to a designed proportion, adding water for decoction for 2-3 times, filtering, concentrating under reduced pressure until the relative density of liquid is 1.02-1.06, and cooling to obtain concentrated solution;
Dissolving borneol in alcohol to obtain a borneol alcohol solution; adding emulsifier into the borneol solution, and uniformly mixing to obtain borneol mixed solution;
And thirdly, uniformly mixing the concentrated solution with the borneol mixed solution, adding a preservative, adding water to ensure that the liquid medicine ratio is 0.9-1:1-1.1, and sterilizing at 120-122 ℃ to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
5. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 4, which is characterized in that: in the first step, the water adding amount is 8-14 times of the mass of the medicine; and/or
In the second step, the mass ratio of the borneol to the alcohol is 1:10-30; and/or
In the second step, the alcohol is ethanol with the mass concentration of 90% -95%; and/or
In the second step, the emulsifier is Tween 80; and/or
In the second step, the mass ratio of the emulsifying agent to the borneol solution is 1-3:100.
6. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 4, which is characterized in that: in the third step, the preservative is one or two of sodium benzoate and ethylparaben; and/or
In the third step, the addition amount of the preservative is 0.5-0.6 wt% of the total amount of the concentrated solution and the borneol mixed solution; and/or
In the third step, the sterilization time is 15min-20min.
7. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 2, which is characterized in that: the method comprises the following steps:
S1, weighing components except the ice flakes according to a designed proportion, adding water for decocting for 2-3 times, filtering, concentrating under reduced pressure, sampling, cooling the sample to 60-65 ℃ for measuring the relative density, stopping concentrating under reduced pressure when the relative density is 1.08-1.25, and cooling to obtain concentrated extract;
s2, weighing auxiliary materials, adding the concentrated extract, uniformly mixing, granulating and drying to obtain granules;
S3, dissolving borneol in alcohol, spraying the borneol on the surfaces of the particles, and drying to obtain the traditional Chinese medicine preparation for treating the poultry bronchial embolism.
8. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 7, which is characterized in that: in S2, the auxiliary materials are sugar powder and dextrin with the mass ratio of 3-10:1.
9. The method for preparing the traditional Chinese medicine preparation for treating the bronchi embolism of poultry according to claim 7, which is characterized in that: in S2, the dosage of the auxiliary materials is 3-6 times of that of the concentrated extract.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249159A (en) * | 2008-01-31 | 2008-08-27 | 南通精华制药股份有限公司 | Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease |
| CN102309563A (en) * | 2011-09-21 | 2012-01-11 | 河北征宇制药有限公司 | Medicinal preparation used for treating diarrhoea of livestock and poultry |
| CN104208394A (en) * | 2013-09-30 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for preventing and treating poultry infectious laryngotracheitis and preparation method thereof |
| CN109464521A (en) * | 2018-12-15 | 2019-03-15 | 瑞普（天津）生物药业有限公司 | It is a kind of for preventing and treating the Chinese medicine composition of chicken bronchial embolism |
| CN110151900A (en) * | 2019-07-11 | 2019-08-23 | 施瑞客（天津）生物技术有限公司 | A kind of extract oral solution and preparation method thereof for poultry bronchial embolization |
| CN112089799A (en) * | 2020-10-15 | 2020-12-18 | 河北象大合众生物科技有限公司 | Compound preparation for treating chicken bronchial embolism and preparation method thereof |
-
2023
- 2023-08-22 CN CN202311060692.4A patent/CN116832091B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101249159A (en) * | 2008-01-31 | 2008-08-27 | 南通精华制药股份有限公司 | Quick acting preparations preparation for preventing and treating chronic emphraxis pulmonary disease |
| CN102309563A (en) * | 2011-09-21 | 2012-01-11 | 河北征宇制药有限公司 | Medicinal preparation used for treating diarrhoea of livestock and poultry |
| CN104208394A (en) * | 2013-09-30 | 2014-12-17 | 郑州后羿制药有限公司 | Traditional Chinese medicine composition for preventing and treating poultry infectious laryngotracheitis and preparation method thereof |
| CN109464521A (en) * | 2018-12-15 | 2019-03-15 | 瑞普（天津）生物药业有限公司 | It is a kind of for preventing and treating the Chinese medicine composition of chicken bronchial embolism |
| CN110151900A (en) * | 2019-07-11 | 2019-08-23 | 施瑞客（天津）生物技术有限公司 | A kind of extract oral solution and preparation method thereof for poultry bronchial embolization |
| CN112089799A (en) * | 2020-10-15 | 2020-12-18 | 河北象大合众生物科技有限公司 | Compound preparation for treating chicken bronchial embolism and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 血府逐瘀汤治疗闭塞性细支气管炎12例;于素平;河南中医;20140901;34(09);1767-1768 * |
| 鸡传染性支气管炎(传支)及并发症的治疗;李雷，等;家禽科学;20080505(05);51 * |
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