CN102309563A - Medicinal preparation used for treating diarrhoea of livestock and poultry - Google Patents
Medicinal preparation used for treating diarrhoea of livestock and poultry Download PDFInfo
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Abstract
The invention discloses a medicinal preparation used for protecting the livestock and poultry from diarrhea, which comprises the following raw materials by weight ratio: 1-20 parts of Radix Astragali, 1-20 parts of bighead atractylodes rhizome, 1-20 parts of licorice, 2-40 parts of white peony root, 20-150 parts of Limonite, 20-150 parts of red halloysite, 2-20 parts of pomegranate rind, 20-100 parts of alum, 3-30 parts of radix bupleuri, 4-10 parts of cimicifuga foetida, 1-20 parts of coptis and 0-3 parts of diphenoxylate. The components of the medicinal preparation are direct and mutual synergism, and has efficacy of supplementing the center and boosting qi, lifting up Yang and depression, antidarrhea with astringent, inhibiting smooth muscle spasm of gastrointestinal tract and alleviating peristaltic of gastrointestinal tract, and is capable of rapidly recovering the functions of gastrointestinal tract, thereby, the medicinal preparation has an obvious function of weight increasing.
Description
Technical field
The present invention relates to the veterinary drug preparation, specifically a kind ofly be used to treat the pharmaceutical preparation of fowl diarrheal.
Background technology
Diarrhoea is a kind of commonly encountered diseases of fowl, mainly show have loose bowels, stool colour is undesired, spirit is depressed, feather is fluffy and disorderly etc.Be used to treat bacterial diarrhea at present and adopt antibiotics or sulfa drugs usually; As give disease fowl oxytetracycline (50 milligrams-100 milligrams of pers kilogram of body weight for oral administration; Batch mixing concentration is 0.02%-0.08%) or polygynax aqueous solution (1g/L, every day 2 times, logotype 35 days).The problem that adopts the treatment of antibiotics or sulfa drugs to exist is, drug dose should not be controlled, when dosage less or administration time more in short-term, its produce effects is slow, weak curative effect, be prone to recurrence; When excessive or administration time is long when dosage, usually can cause drug intoxication again, increase the weight of the symptom of diarrhea of sick fowl conversely again.
Summary of the invention
The object of the invention will provide a kind of exactly and is used to treat that fowl diarrhoea produce effects is fast, good effect, toxic and side effects are little, and can effectively improve the pharmaceutical preparation that fowl is delivered body weight for sale.
The objective of the invention is to realize through following technical scheme:
Provided by the present inventionly be used to treat the pharmaceutical preparation of fowl diarrheal, comprise the raw material of following weight part ratio: Radix Astragali 1-20 part, Rhizoma Atractylodis Macrocephalae 1-20 part, Radix Glycyrrhizae 1-20 part, Radix Paeoniae Alba 2-40 part, Limonitum 20-150 part, Halloysitum Rubrum 20-150 part, Pericarpium Granati 2-20 part, Alumen 20-100 part, Radix Bupleuri 3-30 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-20 part, diphenoxylate 0-3 part.
Provided by the present inventionly be used to treat the pharmaceutical preparation of fowl diarrheal, its preferred feedstock proportioning is:
Radix Astragali 5-15 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Glycyrrhizae 5-20 part, Radix Paeoniae Alba 20-40 part, Limonitum 50-100 part, Halloysitum Rubrum 75-100 part, Pericarpium Granati 5-8 part, Alumen 80-100 part, Radix Bupleuri 20-30 part, Rhizoma Cimicifugae 8-10 part, Rhizoma Coptidis 10-15 part, diphenoxylate 1.5-2.0 part.
Or:
Radix Astragali 10-20 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Paeoniae Alba 10-30 part, Limonitum 75-100 part, Halloysitum Rubrum 20-150 part, Pericarpium Granati 2-10 part, Alumen 30-50 part, Radix Bupleuri 10-15 part, Rhizoma Cimicifugae 5-6 part, Rhizoma Coptidis 5-20 part.
Or:
Radix Astragali 1-5 part, Rhizoma Atractylodis Macrocephalae 1-5 part, Radix Glycyrrhizae 1-5 part, Radix Paeoniae Alba 2-8 part, Limonitum 20-80 part, Halloysitum Rubrum 20-80 part, Pericarpium Granati 4.6-16 part, Alumen 20-35 part, Radix Bupleuri 4-14 part, Rhizoma Cimicifugae 4-8 part, Rhizoma Coptidis 2-15 part, diphenoxylate 0.4-1.0 part.
Provided by the present inventionly be used to treat the pharmaceutical preparation of fowl diarrheal, its more preferred proportioning raw materials is:
1 part of the Radix Astragali, 1 part of the Rhizoma Atractylodis Macrocephalae, 2 parts in Radix Glycyrrhizae, 4 parts of the Radix Paeoniae Albas, 20 parts of Limonitum, 20 parts of Halloysitum Rubrums, 16 parts of Pericarpium Granatis, 20 parts in Alumen, 5 parts of Radix Bupleuri, 10 parts of Rhizoma Cimicifugaes, 2 parts of Rhizoma Coptidis, 0.9 part of diphenoxylate.
Adopt not only good effect of above-mentioned preferred version drug prepared preparation, and cost is low, so its cost performance is more excellent.
Therefore the mutual Synergistic of each component in the pharmaceutical preparation of the present invention has invigorating the spleen and replenishing QI, ascending up spleen-Qi and Yang, relieving diarrhea with astringents, inhibition gastrointestinal smooth muscle spasm, slows down the effect of gastrointestinal peristalsis.It not only has antidiarrheal effect, can recover the body gastrointestinal function rapidly simultaneously, therefore also has tangible effect of gain.
The Radix Astragali in the pharmaceutical preparation of the present invention, the Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening that matches; The Radix Astragali, the Rhizoma Cimicifugae gas in the elevate a turnable ladder that matches, Radix Astragali QI invigorating simultaneously, Rhizoma Cimicifugae rises the stomach sun, the ability that matches ascending up spleen-Qi and Yang; Halloysitum Rubrum, Limonitum phase counterweight astringent therapy; The Rhizoma Coptidis Radix Puerariae matches, and light clear liter of its Radix Puerariae floated, and the bright exterior-heat of Xie Yang is inspired gastric qi, born fluid, and the hard intestinal antidiarrheal of the clear interior-heat of Rhizoma Coptidis bitter cold, the two mutual-assistance is a usefulness, the clearing away heat to stop diarrhea effect is more remarkable; The nourishing the stomach of promoting the production of body fluid of Radix Puerariae, Rhizoma Atractylodis Macrocephalae compatibility, its Radix Puerariae, Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, invigorating the spleen to arrest diarrhea matches; Rhizoma Cimicifugae, Radix Bupleuri compatibility, its two medicine all has heat radiation, recommends effect, and the clearing heat in QI system that the Rhizoma Cimicifugae yang invigorating is bright, Radix Bupleuri rise the clear sun of liver and gall, and the two mutual reinforcement between is a usefulness, goes in the QI replenishing and blood harmonizing agent, controls the proctoptosis with chronic dysentery of yang-energy inward penetration of pathogen due to deficiency; Radix Glycyrrhizae, Alumen, Pericarpium Granati and Limonitum, Halloysitum Rubrum share the further antibacterial antidiarrheal effect that strengthened, and wherein Alumen and other drug share and not only can strengthen antidiarrheal effect and can also reduce cost.
The screening of each component and consumption proportion is confirmed to be through the acquisition of prolonged and repeated research side among the present invention.The Radix Astragali among the present invention, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, its consumption of the Radix Paeoniae Alba increase not significantly influence of therapeutic effect, but the consumption increasing has promptly increased the product cost amount.But its consumption is crossed the low effect that does not promptly have invigorating the spleen and replenishing QI.Suitably increase diphenoxylate among the present invention, can further improve curative effect, but its consumption is when excessive, the side effect meeting increases thereupon.Limonitum among the present invention, Pericarpium Granati, cause constipation when the Halloysitum Rubrum consumption is excessive easily, then affect the treatment, also be unfavorable for reducing cost but consumption is too small.
Its instant effect of pharmaceutical preparation of the present invention, short treating period, side effect are little, and not only can treat animal diarrhoea can also increase and deliver weight for sale, so the trade name of pharmaceutical preparation of the present invention is decided to be " the antidiarrheal weightening finish is loose ".
Pharmaceutical preparation of the present invention shows through the clinical trial of selecting natural occurrence fowl for use, and to the sick fowl of light disease one day, the sick fowl medication of serious symptom can be cured in 3 days, and its curative effect obviously is superior to the polygynax soluble powder, and does not find to have untoward reaction.
Pharmaceutical preparation according to the invention can be prepared into powder, granule or suspensoid etc. according to the conventional medicine formulation method.
At this, the present invention provides a kind of method for preparing of powder: the prepared slices of Chinese crude drugs are ground into coarse powder, and behind the abundant then mix homogeneously, packing (250g/ bag).If in prescription, add diphenoxylate, can, Chinese medicine add diphenoxylate again after pulverizing, fully packing again behind the mix homogeneously.
Pharmaceutical preparation of the present invention in use can be with reference to once usage, consumption:
The every 250g of these article, but spice 250kg, the whole day consumption is concentrated once and is used, once a day.
Should note when pharmaceutical preparation of the present invention is used: each flavour of a drug consumption of these article is sufficient, need not use by dosage, can recover voluntarily after 24 hours if any the drug withdrawal of constipation phenomenon during the medication.
The specific embodiment
Embodiment 1 (the antidiarrheal weightening finish is loose I number):
Take by weighing Radix Astragali 8kg, Rhizoma Atractylodis Macrocephalae 8kg, Radix Glycyrrhizae 8kg, Radix Paeoniae Alba 8kg, Limonitum 20kg, Halloysitum Rubrum 50kg, Pericarpium Granati 10kg, Alumen 25kg, Radix Bupleuri 14kg, Rhizoma Cimicifugae 10kg, Rhizoma Coptidis 20kg.With above-mentioned prepared slices of Chinese crude drugs pulverize separately, cross 100 mesh sieves, mix homogeneously is distributed into every bag of 250g.
Embodiment 2 (weightening finish ZHIXIE SAN II number):
Take by weighing Radix Astragali 2kg, Rhizoma Atractylodis Macrocephalae 2kg, Radix Glycyrrhizae 3kg, Radix Paeoniae Alba 3kg, Limonitum 50kg, Halloysitum Rubrum 20kg, Pericarpium Granati 4.6kg, Alumen 35kg, Radix Bupleuri 4kg, Rhizoma Cimicifugae 4kg, Rhizoma Coptidis 2kg, diphenoxylate 0.4kg.
With above-mentioned prepared slices of Chinese crude drugs pulverize separately, cross 80 mesh sieves, mix homogeneously adds diphenoxylate, and mix homogeneously is distributed into every bag of 250g once more.
Embodiment 3 (the antidiarrheal weightening finish is loose III number):
Prescription: Radix Astragali 1kg, Rhizoma Atractylodis Macrocephalae 1kg, Radix Glycyrrhizae 2kg, Radix Paeoniae Alba 4kg, Limonitum 20kg, Halloysitum Rubrum 20kg, Pericarpium Granati 16kg, Alumen 20kg, Radix Bupleuri 5kg, Rhizoma Cimicifugae 8kg, Rhizoma Coptidis 2kg, diphenoxylate 0.9kg.
Method for preparing is with embodiment 2.
Embodiment 6-9
Wherein the therapeutic effect of embodiment 6 and embodiment 1 are basic identical, and the therapeutic effect of embodiment 7-9 and embodiment 2 are basic identical.
The curative effect checking of embodiment 10 pharmaceutical preparatioies of the present invention.
1 material and method
1.1 experimental animal
8000 of the blue brown laying hens in 280 ages in days sea.
1.2 trial drug
Embodiment 1, embodiment 2, embodiment 3 drug prepared preparations, specification: the 250g/ bag, lot number is respectively: 2011010101,2011010102,2011010103, effluent northward fight space pharmaceutical Co. Ltd provides; The polygynax soluble powder, specification: 10 bags/barrel in 32.5%100g/ bag, lot number: 20101201, effluent northward fight space pharmaceutical Co. Ltd provides.
1.2 test and Selection chicken
Clinical symptoms is diagnosed as the blue brown laying hen in diarrheal 280 ages in days sea that escherichia coli cause in the nearly week age.
1.3. laboratory diagnosis:
The antibacterial dyeing microscopic examination is aseptic take the to die of illness heart, the hepatic tissue smear of chicken, gram stain microscopy, visible have singlely be dispersed in or become the gram negative bacilli of double row, the blunt circle in two ends to exist.
The antibacterial separation and Culture is aseptic take the to die of illness heart, the hepatic tissue of chicken; Be inoculated in plain agar culture medium and maconkey agar culture medium respectively; In 37 ℃ of calorstats, cultivated 18 hours; Can find that the bacterium colony on the Mai Kangkai culture medium takes on a red color, it is 1～3 millimeter bacterium colony that neat in edge, protuberance, canescence, diameter are arranged on the plain agar culture medium.The picking colony smear for microscopic examination, visible Gram-negative bacillus does not form spore, and most bacterial strains can move amphitrichous.
The antibacterial biochemical reaction is done biochemical test with the bacterium colony of above-mentioned cultivation, and this bacterium can produce indole, and decomposing urea does not produce hydrogen sulfide, and liquefy gelatin not, MR are tested positive, and VP test negative, can glucose fermentation, lactose, mannitol, the sour aerogenesis of product.
1.4 test method:
The chicken crowd is divided into 4 groups at random; 2000 chicken/groups; The present invention takes embodiment 1 made preparation for 1 group, and the present invention takes embodiment 2 made preparations for 2 groups, and the present invention takes embodiment 3 made preparations for 3 groups; The polygynax group is taken the polygynax soluble powder, offers medicine by processing method described in the table 1.See table 1 for details.
Table 1
| Group | The plumage number | Body weight (g) | Processing method |
| The polygynax group | 2000 | 1840.33±51.89 | L water/1g mixes and raises |
| 1 group of the present invention | 2000 | 1837.00±50.18 | 1kg feedstuff/1g mixes and raises |
| 2 groups of the present invention | 2000 | 1980.00±50.18 | 1kg feedstuff/1g mixes and raises |
| 3 groups of the present invention | 2000 | 1990.00±50.18 | 1kg feedstuff/1g mixes and raises |
The body weight of each group before treatment do not have significant difference, has comparability.
1.4.1 feeding and management
Conventional feeding manner, free choice feeding and drinking-water, suitably ventilation.
1.4.2 administration
Polygynax group whole day consumption single administration, each-hour, successive administration 3 days; Of the present invention group every bag spice 250kg, once a day, logotype 3 days.
1.4.3 efficacy evaluation index
Cure duration of test, medication chicken clinical symptom disappearance.Calculate its cure rate according to curing number.
The chicken plumage that produce effects duration of test, the chicken of healing or clinical symptoms obviously alleviate or disappear all is judged to be produce effects.Calculate its obvious effective rate according to the produce effects number.
During the efficiency test, the chicken that the clinical symptoms of medication postoperative infection chicken alleviates to some extent then all is judged to be effectively.Calculate its effective percentage according to significant figure.
Invalid duration of test, after the medication clinical symptoms do not see alleviate or disappear and dead chicken plumage all be judged to be invalid.
1.4.4 weigh
Before dividing into groups and after the treatment end, test chicken is weighed, and record, average weight gain calculated.
1.4.4 handling, data analysis adopt the SPSS12.0 Biological Statistic Analysis Software to carry out the significance test of data.
2 result of the tests see table 2 for details.
Table 2 result of the test statistical analysis
Annotate: on behalf of drug group of the present invention, * compare significant difference (P＜0.05) with the polygynax group;
On behalf of drug group of the present invention, * compare difference highly significant (P＜0.01) with the polygynax group
Can find out that from above experiment the embodiment of the invention 1 drug prepared preparation is compared with the polygynax soluble powder, cure rate, obvious effective rate, average weight gain have significant difference; The embodiment of the invention 2, embodiment 3 drug prepared preparations are compared with the polygynax soluble powder, and its cure rate, obvious effective rate, average weight gain have the difference of highly significant.
This shows that produce effects of the present invention is fast, good effect, and effectively body weight is delivered in the chicken raising for sale.Moreover contained chemicals becomes split pole low in the present invention's prescription, therefore can reduce the toxicity of medicine greatly.
Embodiment 11
In order to verify the clinical effectiveness of pharmaceutical preparation treatment duck coliform diarrhea of the present invention; Select for use natural occurrence duck crowd to carry out clinical trial; Through comparing with the control drug gentamycin sulfate soluble powder, the result shows that pharmaceutical preparation of the present invention is used to treat its cure rate of duck coliform diarrhea apparently higher than gentamycin sulfate soluble powder, short treating period; With low cost, suitable large-scale promotion.
1 material and method
1.1 experimental animal: 5000 of 40 age in days meat-type duck.
1.2 trial drug:
Embodiment 2 drug prepared preparations, specification: the 250g/ bag, lot number: 2011010102, effluent northward fight space pharmaceutical Co. Ltd provides; Gentamycin sulfate soluble powder, specification: the 5%50g/ bag, lot number: 20101201, effluent northward fight space pharmaceutical Co. Ltd provides.
1.3.1 clinical and diagnosis 5000 of Distributions in Liaocheng of Shandong Province * on the 10th * * * duckery 40 age in days meat-type duck March in 2011, watery diarrhea appears in nearly week age chicken crowd, and feed intake descends 3%, and spirit is normal, is diagnosed as the diarrhoea that escherichia coli cause according to clinical symptoms.
1.3.2 laboratory diagnosis:
The antibacterial dyeing microscopic examination is aseptic take the to fall ill heart, the hepatic tissue smear of duck, gram stain microscopy, visible have singlely be dispersed in or become the gram negative bacilli of double row, the blunt circle in two ends to exist.
The antibacterial separation and Culture is aseptic take the to fall ill heart, the hepatic tissue of duck; Be inoculated in plain agar culture medium and maconkey agar culture medium respectively; In 37 ℃ of calorstats, cultivated 18 hours; Can find that the bacterium colony on the Mai Kangkai culture medium takes on a red color, it is 1～3 millimeter bacterium colony that neat in edge, protuberance, canescence, diameter are arranged on the plain agar culture medium.The picking colony smear for microscopic examination, visible Gram-negative bacillus does not form spore, and most bacterial strains can move amphitrichous.
The antibacterial biochemical reaction is done biochemical test with the bacterium colony of above-mentioned cultivation, and this bacterium can produce indole, and decomposing urea does not produce hydrogen sulfide, and liquefy gelatin not, MR are tested positive, and VP test negative, can glucose fermentation, lactose, mannitol, the sour aerogenesis of product.
1.4 test method
The duck crowd is divided into two groups at random, and 2500 duck/groups are used weightening finish ZHIXIE SAN II number for one group, and another group is used gentamycin sulfate soluble powder, offers medicine by the explanation amount.See table 3. for details
Table 3 test is divided into groups
| Group number | Group | The plumage number | Body weight (g) | Processing method |
| 1 | The gentamycin sulfate group | 2500 | 1840.33±51.89 | L water/1g mixes and raises |
| 2 | II number group of weightening finish ZHIXIE SAN | 2500 | 1837.00±50.18 | 1kg feedstuff/1g mixes and raises |
1.4.4 feeding and management
Conventional feeding manner, free choice feeding and drinking-water, suitably ventilation.
1.4.5 administration
First group of whole day consumption single administration, each-hour, successive administration 3 days; Second group every bag spice 250kg, once a day, logotype 3 days.
1.4.7 efficacy evaluation index
Cure duration of test, medication duck clinical symptom disappearance.Calculate its cure rate according to curing number.
The produce effects duration of test, the duck that the duck of healing or clinical symptoms obviously alleviate or disappear all is judged to be produce effects.Calculate its obvious effective rate according to the produce effects number.
During the efficiency test, the duck that the clinical symptoms of medication postoperative infection duck alleviates to some extent then all is judged to be effectively.Calculate its effective percentage according to significant figure.
Invalid duration of test, after the medication clinical symptoms do not see alleviate or disappear and dead duck all be judged to be invalid.
1.4.9 weigh
Before dividing into groups and after the treatment end, the test duck is weighed, and record, average weight gain calculated.
1.4.10 handling, data analysis adopt the SPSS12.0 Biological Statistic Analysis Software to carry out the significance test of data.
2 results
2.2 average weight gain
First group and second group is increased weight relatively first group and second group of average weight gain significant difference (P＜0.05).
2.3 effective percentage, obvious effective rate, cure rate
Significant difference (P＜0.05) on two groups of cure rates, obvious effective rate, the effective percentage.See table 4. for details
Table 4 clinical effectiveness statistical analysis
Annotate: significant difference (P＜0.05) is compared in the * representative with the medicine matched group;
Can find out that from above experiment the embodiment of the invention 2 drug prepared preparations are compared with the polygynax soluble powder, cure rate, obvious effective rate, average weight gain have significant difference.
This shows that produce effects of the present invention is fast, good effect, and can effectively improve duck and deliver body weight for sale.
Claims (5)
1. one kind is used to treat the pharmaceutical preparation of fowl diarrheal, comprises the raw material of following weight part ratio: Radix Astragali 1-20 part, Rhizoma Atractylodis Macrocephalae 1-20 part, Radix Glycyrrhizae 1-20 part, Radix Paeoniae Alba 2-40 part, Limonitum 20-150 part, Halloysitum Rubrum 20-150 part, Pericarpium Granati 2-20 part, Alumen 20-100 part, Radix Bupleuri 3-30 part, Rhizoma Cimicifugae 4-10 part, Rhizoma Coptidis 1-20 part, diphenoxylate 0-3 part.
2. be used to treat the pharmaceutical preparation of fowl diarrheal according to claim 1 is said, it is characterized in that it comprises the raw material of following weight part ratio:
Radix Astragali 5-15 part, Rhizoma Atractylodis Macrocephalae 15-20 part, Radix Glycyrrhizae 5-20 part, Radix Paeoniae Alba 20-40 part, Limonitum 50-100 part, Halloysitum Rubrum 75-100 part, Pericarpium Granati 5-8 part, Alumen 80-100 part, Radix Bupleuri 20-30 part, Rhizoma Cimicifugae 8-10 part, Rhizoma Coptidis 10-15 part, diphenoxylate 1.5-2.0 part.
3. be used to treat the pharmaceutical preparation of fowl diarrheal according to claim 1 is said, it is characterized in that it comprises the raw material of following weight part ratio:
Radix Astragali 10-20 part, Rhizoma Atractylodis Macrocephalae 5-10 part, Radix Glycyrrhizae 5-10 part, Radix Paeoniae Alba 10-30 part, Limonitum 75-100 part, Halloysitum Rubrum 20-150 part, Pericarpium Granati 2-10 part, Alumen 30-50 part, Radix Bupleuri 10-15 part, Rhizoma Cimicifugae 5-6 part, Rhizoma Coptidis 5-20 part.
4. be used to treat the pharmaceutical preparation of fowl diarrheal according to claim 1 is said, it is characterized in that it comprises the raw material of following weight part ratio:
Radix Astragali 1-5 part, Rhizoma Atractylodis Macrocephalae 1-5 part, Radix Glycyrrhizae 1-5 part, Radix Paeoniae Alba 2-8 part, Limonitum 20-80 part, Halloysitum Rubrum 20-80 part, Pericarpium Granati 4.6-16 part, Alumen 20-35 part, Radix Bupleuri 4-14 part, Rhizoma Cimicifugae 4-8 part, Rhizoma Coptidis 2-15 part, diphenoxylate 0.4-1.0 part.
5. be used to treat the pharmaceutical preparation of fowl diarrheal according to claim 1 is said, it is characterized in that it comprises the raw material of following weight part ratio:
1 part of the Radix Astragali, 1 part of the Rhizoma Atractylodis Macrocephalae, 2 parts in Radix Glycyrrhizae, 4 parts of the Radix Paeoniae Albas, 20 parts of Limonitum, 20 parts of Halloysitum Rubrums, 16 parts of Pericarpium Granatis, 20 parts in Alumen, 5 parts of Radix Bupleuri, 10 parts of Rhizoma Cimicifugaes, 2 parts of Rhizoma Coptidis, 0.9 part of diphenoxylate.
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| CN105031670A (en) * | 2015-08-11 | 2015-11-11 | 青岛市中心医院 | Gastrointestinal tract contrast agent |
| CN116832091A (en) * | 2023-08-22 | 2023-10-03 | 河北征宇制药有限公司 | Traditional Chinese medicine composition for treating poultry bronchial embolism, preparation and preparation method and application thereof |
| CN116832091B (en) * | 2023-08-22 | 2024-04-23 | 河北征宇制药有限公司 | Traditional Chinese medicine composition for treating poultry bronchial embolism, preparation and preparation method and application thereof |
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