CN103055187A - Traditional Chinese medicine composition for treating cough with asthma and influenza of pigs and application of traditional Chinese medicine composition in feed - Google Patents
Traditional Chinese medicine composition for treating cough with asthma and influenza of pigs and application of traditional Chinese medicine composition in feed Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating cough with asthma and influenza of pigs. The traditional Chinese medicine composition comprises active components prepared from rhizoma anemarrhenae, common andrographis herb, radix ophiopogonis, radix scrophulariae, shrubalthea flower, lophatherum gracile, platycodon grandiflorum, radix bupleuri, selfheal, honeysuckle, forsythia, radix scutellariae, angelica, radix paeoniae rubra and radix glycyrrhizae. The traditional Chinese medicine composition has the composite effect of treatment based on syndrome differentiation and good curative effect, takes effect quickly and treats both principal and secondary aspects of diseases; and the traditional Chinese medicine composition can be used for treating cough with asthma and influenza of the pigs and has the characteristics of simple preparation technology, remarkable efficacy, low cost, safety, convenience to take and the like.
Description
Technical field
The present invention relates to the application in a kind of Chinese medicine that is used for the treatment of pig cough illness and influenza disease and preparation method thereof and the feedstuff, belong to field of veterinary and field of fodder.
Background technology
The pig cough illness is the common disease that affects the pig normal growth, it also is one of principal disease that affects at present the pig rate of animals delivered to the slaughter-house, intensive along with aquaculture, raiser and veterinarys have to the pig cough illness is kept a close eye on, especially in winter of cold, the pig cough illness is more rampant, has caused no small economic loss to the raiser, has affected the rate of animals delivered to the slaughter-house of growing and fattening pigs; The cough illness of pig affects sleep and the growth promoter of pig, treats untimelyly to be transformed into chronicly, forms pleuropneumonia, and the growth phase of pig is when slow like this.The cough illness of pig is transformed into the chronic difficult for the treatment of later on, and Chinese veterinarian has saying of " do not control tinea outward, interior not controlling being breathed heavily ".Because the cause of disease of pig cough illness is complicated, clinical treatment gets up just certain difficulty, uses in a large number antibiotic and escalated dose cross infection and the generation bacterial drug resistance problem of disease can occur again, and cures the symptoms, not the disease.Follow antibiotic to be widely used, the problems such as drug residue are day by day serious, find out a kind of good effect, Chinese medicine that drug residue is few becomes inexorable trend, and the veterinary personnel's is duty-bound especially.
Chinese medicine not only can prevent and treat disease, can also provide some nutrient substance and trace element to animal body, strengthens the immunity of animal body self, has reduced the probability that animal has an attack of one's old illness.Therefore, from Chinese herbal medicine, seek and work out the effective ingredient of this type of disease for the treatment of, develop Chinese medicine preparation safe, efficient, environmental protection and be significant.
Summary of the invention
The object of the invention be to provide a kind of evident in efficacy, safe, drug residue is low, environmental protection be used for the treatment of pig cough illness and grippal Chinese medicine composition.
Another object of the present invention provides a kind of preparation method for the treatment of pig cough illness and grippal Chinese medicine composition.
The invention provides a kind of pig cough illness and grippal Chinese medicine composition for the treatment of, it contains active component, and described active component is made by the Rhizoma Anemarrhenae, Herba Andrographis, Radix Ophiopogonis, Radix Scrophulariae, Flos Hibisci, Herba Lophatheri, Radix Platycodonis, Radix Bupleuri, Spica Prunellae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Radix Glycyrrhizae.
Wherein, described active component is made by Rhizoma Anemarrhenae 20-30 part, Herba Andrographis 10-15 part, Radix Ophiopogonis 15-25 part, Radix Scrophulariae 20-30 part, Flos Hibisci 10-15 part, Herba Lophatheri 10-20 part, Radix Platycodonis 10-20 part, Radix Bupleuri 20-30 part, Spica Prunellae 10-20 part, Flos Lonicerae 20-35 part, Fructus Forsythiae 20-35 part, Radix Scutellariae 20-35 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Glycyrrhizae 10-20 part.
Further, described active component is made by Rhizoma Anemarrhenae 25-30 part, Herba Andrographis 12-15 part, Radix Ophiopogonis 14-21 part, Radix Scrophulariae 22-28 part, Flos Hibisci 12-15 part, Herba Lophatheri 15-20 part, Radix Platycodonis 15-20 part, Radix Bupleuri 25-30 part, Spica Prunellae 15-20 part, Flos Lonicerae 25-30 part, Fructus Forsythiae 25-30 part, Radix Scutellariae 25-30 part, Radix Angelicae Sinensis 12-18 part, Radix Paeoniae Rubra 12-18 part, Radix Glycyrrhizae 15-20 part.
Further, described active component is made by 15 parts of 28 parts of the Rhizoma Anemarrhenaes, 13 parts of Herba Andrographis, 20 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariae, 13 parts of Flos Hibisci, 16 parts of Herba Lophatheris, 18 parts of Radix Platycodoniss, 26 parts of Radix Bupleuri, 18 parts of Spica Prunellaes, 28 parts of Flos Loniceraes, 27 parts of Fructus Forsythiaes, 28 parts of Radix Scutellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, Radix Glycyrrhizae.
Wherein, described Chinese medicine composition can be pre-mixing agent, powder, powder, granule, oral liquid or injection.
The present invention also provides a kind of preparation method for the treatment of pig cough illness and influenza Chinese medicine composition, comprises the steps:
1) takes by weighing by weight ratio each medicine material;
2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material through water or alcohol extraction, concentrated after, add again adjuvant or complementary composition that pharmacy can be used, be prepared from.
Wherein, described adjuvant is selected from one or more in dextrin, starch, lactose and the sucrose.
Chinese medicine composition of the present invention can be used for preparation treatment cough illness and grippal medicine.
Chinese medicine composition of the present invention can also add in the feedstuff, and therefore Chinese medicine composition of the present invention can also be for the preparation for the treatment of cough illness and grippal feedstuff.
Each drug component in the Chinese medicine of the present invention and consumption thereof be to control principle according to the dialectical opinion of Chinese veterinarian's pharmacology of Chinese medical formulae, gets by repeatedly practising in a large number, can effectively be used for the treatment of the diseases such as pig cough illness, swine influenza.
Advantage and the beneficial effect of medicine of the present invention are:
(1) the dialectical combined effect of controlling of executing of Chinese medicine performance Chinese medicinal formulae of the present invention, good effect, instant effect, treating both the principal and secondary aspects of a disease, can be used for treating pig disease of cough and asthma and swine influenza, have the characteristics such as preparation technology is simple, drug effect is remarkable, with low cost, safe, easy to use;
(2) medicine of the present invention has solved pig disease of cough and asthma and the rate of animals delivered to the slaughter-house contradiction between low, and cough illness, the influenza of pig had preferably therapeutic effect;
(3) medicine of the present invention can prevent effectively that bacterial drug resistance from producing, and avoids carnivore drug residue problem etc., has ensured safety and the Environmental security of animal food;
(4) Chinese medicine of the present invention adopts the modern pharmaceutical technology to be prepared, and uses modern means of science and technology that Effective Component of Chinese Medicine is carried out qualitative and quantitative detection, and constant product quality, controlled has the stronger market competitiveness.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 medicine preparation of the present invention and use
Take by weighing the raw material that contains following weight parts:
30 parts of the Rhizoma Anemarrhenaes, 15 parts of Herba Andrographis, 25 parts of Radix Ophiopogonis, 30 parts of Radix Scrophulariae, 15 parts of Flos Hibisci, 20 parts of Herba Lophatheris, 20 parts of Radix Platycodoniss, 30 parts of Radix Bupleuri, 20 parts of Spica Prunellaes, 35 parts of Flos Loniceraes, 35 parts of Fructus Forsythiaes, 35 parts of Radix Scutellariaes, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Paeoniae Rubra, 20 parts in Radix Glycyrrhizae.
With step (1) claim each weight crude drug pulverize, sieve after, fully mixing is made powder.
Drug use method of the present invention: mixed feeding; The every 1kg feedstuff of piglet adds medicine 10g of the present invention, is used in conjunction 7.
Embodiment 2 medicine preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight parts:
20 parts of the Rhizoma Anemarrhenaes, 10 parts of Herba Andrographis, 15 parts of Radix Ophiopogonis, 20 parts of Radix Scrophulariae, 10 parts of Flos Hibisci, 10 parts of Herba Lophatheris, 10 parts of Radix Platycodoniss, 20 parts of Radix Bupleuri, 10 parts of Spica Prunellaes, 20 parts of Flos Loniceraes, 20 parts of Fructus Forsythiaes, 20 parts of Radix Scutellariaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 10 parts in Radix Glycyrrhizae.
(2) with claim in the step (1) each weight proportion raw material pulverize after, mention after half an hour with 80% soak with ethanol, extract 2h at every turn, filter, residual residue is with distilled water extraction 2 times, each 1h, filtration.Collecting decoction is condensed into thick paste, adds the medicinal dextrin mix homogeneously, granulates oven dry, granulation agent (every 1g is equivalent to crude drug in whole 2.5g)
Drug use method of the present invention: mixed drink; The every 1L water of pig adds medicine 1.0g of the present invention, freely drinks, and is used in conjunction 7.
Embodiment 3 medicine preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight parts:
25 parts of the Rhizoma Anemarrhenaes, 12 parts of Herba Andrographis, 20 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariae, 12 parts of Flos Hibisci, 15 parts of Herba Lophatheris, 15 parts of Radix Platycodoniss, 25 parts of Radix Bupleuri, 15 parts of Spica Prunellaes, 25 parts of Flos Loniceraes, 25 parts of Fructus Forsythiaes, 25 parts of Radix Scutellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts in Radix Glycyrrhizae.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, with ethanol medical material is soaked 2 hours first after, alcohol reflux 2 times, each 2 hours, merging filtrate also was condensed into the thick paste shape; Filtering residue is used water extraction 2 times again, extracts 2.5 hours for the first time, extracts 1.5 hours for the second time, filters, and merging filtrate also is condensed into the thick paste shape; Merge extractum, add at last appropriate amount of starch and dextrin (or other adjuvant), mix homogeneously, oven dry is pulverized, and namely is prepared into powder (every 1g is equivalent to crude drug in whole 1g).
(3) drug use method of the present invention: mixed feeding; The every 1kg feedstuff of pig adds medicine 10g of the present invention, is used in conjunction 7.
Embodiment 4 medicine preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight parts:
22 parts of the Rhizoma Anemarrhenaes, 10 parts of Herba Andrographis, 18 parts of Radix Ophiopogonis, 22 parts of Radix Scrophulariae, 12 parts of Flos Hibisci, 14 parts of Herba Lophatheris, 14 parts of Radix Platycodoniss, 24 parts of Radix Bupleuri, 14 parts of Spica Prunellaes, 24 parts of Flos Loniceraes, 22 parts of Fructus Forsythiaes, 24 parts of Radix Scutellariaes, 12 parts of Radix Angelicae Sinensis, 14 parts of Radix Paeoniae Rubra, 14 parts in Radix Glycyrrhizae.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, then decoct to boiling with high heat, used again slow fire boiling 30 minutes, filter, filtering residue adds water with slow fire boiling twice, each 1 hour.Merging filtrate, adding ethanol ethanol content to the filtrate after filtrate is concentrated is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 2g, and filtration, embedding, sterilization namely are prepared into oral liquid.
(3) drug use method of the present invention: mixed drink; The every 1L water of pig adds medicine 2.0ml of the present invention, freely drinks, and is used in conjunction 7.
Embodiment 5 medicine preparation of the present invention and uses
(1) take by weighing the raw material that contains following weight parts:
28 parts of the Rhizoma Anemarrhenaes, 13 parts of Herba Andrographis, 20 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariae, 13 parts of Flos Hibisci, 16 parts of Herba Lophatheris, 18 parts of Radix Platycodoniss, 26 parts of Radix Bupleuri, 18 parts of Spica Prunellaes, 28 parts of Flos Loniceraes, 27 parts of Fructus Forsythiaes, 28 parts of Radix Scutellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts in Radix Glycyrrhizae.
(2) with claim in the step (1) each weight proportion crude drug pulverize after, after water soaks 1-2 hour with medical material, then decoct to boiling with fire, decocted 30 minutes with little fire again, filter, filtering residue was with little fiery decoction twice, each 1 hour.Merging filtrate, adding ethanol ethanol content to the filtrate after filtrate is concentrated is 70%, filters, and filtrate recycling ethanol is concentrated into every 1ml and is equivalent to crude drug in whole 1g, and cold preservation, filtration, fine straining, embedding, sterilization namely are prepared into injection.
(3) drug use method of the present invention: intramuscular injection, each every 1kg body weight, pig 0.1-0.2ml/kg 1 time on the one, is used in conjunction 7.
For showing medicine of the present invention to the effect of pig cough illness and swine influenza, medicine of the present invention is carried out the clinical observation on the therapeutic effect test, below further set forth the beneficial effect of medicine of the present invention by test example.
Test example 1
On November 10th, 2012, the Chongqing City buys on the Yongchuan District pig farm 300 of piglets, about 22 kilograms of body weight, raise after 7 days, the part pig shows as dyspnea, as drawing bellows, ventral breathing, do not like, become thin, hair is burnt, growth promoter is stagnated, the back of a bow, dry cough is especially to feed pigs or when catching up with pig visible successional spasm and cough early morning.Sick pig is obvious ventral breathing through driveing, hearing that very brief, continuous dry cough, frequency of respiration per minute reach 65-80 time after motion and the feeding, have in addition dehisce to breathe, lassitude is reluctant to walk about.150 pig morbidities are successively arranged, dead 6.Be diagnosed as the pig cough illness through pathologic finding.144 sick pigs are divided into 7 groups for examination.
Test grouping and administration: test is divided into 7 groups, and test 1 group and adopt embodiment 1 preparation, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 15g of the present invention; Test 2 groups and adopt embodiment 2 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 2.0g of the present invention, freely drinks; Test 3 groups and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 15g of the present invention; Test 4 groups and adopt embodiment 4 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 2.0ml of the present invention, freely drinks; Test 5 groups and adopt embodiment 5 preparations, intramuscular administration; The ofloxacin injection group adopts intramuscular injection; The not administration of blank group; All the other each groups are used in conjunction 7.Observed for 2 weeks after the off-test, statistical results see Table 1.
Table 1 medicine of the present invention is added up pig cough illness curative effect
Result of the test shows: compare with the blank group, 6 test group all have significant curative effect to the pig cough illness; Compare with the ofloxacin injection group, 5 groups of medicine of the present invention all are significantly higher than ofloxacin group to pig cough illness prevention effect.Wherein, the effect of 5 groups of medicines is more outstanding.In addition, palatability of drugs of the present invention is good, and the test pig has no side effect and untoward reaction without the refusing to eat phenomenon.
Test example 2
In October, 2012, pig farm, Taiyuan, Shanxi city 200 bull 50-70 kilogram big porkers, symptom appears in most pigs simultaneously in the swinery, the performance anorexia, blunt, depleted, roll up, sick pig is crowded together, conjunctival congestion, eye, nose outflow serosity secretions.The swinery bradykinesia, sick pig is reluctant to walk about, even drives consumingly also motionless.Rapid and ventral breathing appear, and more obvious when particularly forcing the disease pig to walk about, the serious paroxysmal cough of occurring together.Body temperature can up to 40.5～41.7 ℃, conjunctivitis, rhinitis, nasal secretion and sneeze occur.Because anorexia, sick pig body weight obviously descends, and is weak, and clinical diagnosis is swine influenza.With 40 of sick pigs and 195 in time isolation of infection pig, polluted place and pig house carry out strict sterilization.Adopt embodiment 2 preparations medicine of the present invention to treat to 40 sick pigs of isolated rearing, the administration of mixed drink, every 1L water adds Chinese medicine 2.5g of the present invention, freely drinks; Adopt embodiment 1 preparation medicine of the present invention to infecting pig, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 10g of the present invention.Through using continuously medicine of the present invention to pay a return visit after 1 week, except 8 serious sick pig death, all the other 32 sick pigs are almost recovered.Infect swinery and disease do not occur.
Test example 3
In November, 2011, there are 500 big porkers nearly on the Taian Shandong pig farm, and the part pig is generated heat suddenly, and appetite is absolutely useless; Muscle, arthralgia are reluctant to stand; Rapid breathing, ventral breathing, and spasmodic cough is arranged; Whole skin is rubescent, and eye and nose have the symptoms such as mucus outflow.Clinical diagnosis is swine influenza.Selecting wherein, 200 big porkers of serious symptom are divided into 4 groups for examination.
Test grouping and administration: test is divided into 4 groups, and test 1 group and adopt embodiment 3 preparations, the mixed feeding administration, the per kilogram feedstuff adds Chinese medicine 15g of the present invention; Test 2 groups and adopt embodiment 4 preparations, the administration of mixed drink, every 1L water adds Chinese medicine 2.0ml of the present invention, freely drinks; Test 3 groups and adopt potent amoxicillin, the mixed feeding administration, the per kilogram feedstuff adds potent amoxicillin 2g; The not administration of blank group; All the other each groups were used in conjunction for 1 week.Continue after the off-test to observe 3, statistical results see Table 2.
Table 2 medicine of the present invention is added up the swine flue curative effect
Result of the test shows: medicine of the present invention and potent amoxicillin group have good prevention effect to swine flue, and curative effect of medication of the present invention is slightly better than potent amoxicillin.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the technology of the present invention principle; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (9)
1. treat pig cough illness and grippal Chinese medicine composition for one kind, it contains active component, and described active component is made by the Rhizoma Anemarrhenae, Herba Andrographis, Radix Ophiopogonis, Radix Scrophulariae, Flos Hibisci, Herba Lophatheri, Radix Platycodonis, Radix Bupleuri, Spica Prunellae, Flos Lonicerae, Fructus Forsythiae, Radix Scutellariae, Radix Angelicae Sinensis, Radix Paeoniae Rubra and Radix Glycyrrhizae.
2. treatment pig cough illness as claimed in claim 1 and grippal Chinese medicine composition, it is characterized in that, described active component is made by Rhizoma Anemarrhenae 20-30 part, Herba Andrographis 10-15 part, Radix Ophiopogonis 15-25 part, Radix Scrophulariae 20-30 part, Flos Hibisci 10-15 part, Herba Lophatheri 10-20 part, Radix Platycodonis 10-20 part, Radix Bupleuri 20-30 part, Spica Prunellae 10-20 part, Flos Lonicerae 20-35 part, Fructus Forsythiae 20-35 part, Radix Scutellariae 20-35 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Rubra 10-20 part, Radix Glycyrrhizae 10-20 part.
3. treatment pig cough illness as claimed in claim 2 and grippal Chinese medicine composition, it is characterized in that, described active component is made by Rhizoma Anemarrhenae 25-30 part, Herba Andrographis 12-15 part, Radix Ophiopogonis 14-21 part, Radix Scrophulariae 22-28 part, Flos Hibisci 12-15 part, Herba Lophatheri 15-20 part, Radix Platycodonis 15-20 part, Radix Bupleuri 25-30 part, Spica Prunellae 15-25 part, Flos Lonicerae 25-30 part, Fructus Forsythiae 25-30 part, Radix Scutellariae 25-30 part, Radix Angelicae Sinensis 12-18 part, Radix Paeoniae Rubra 12-18 part, Radix Glycyrrhizae 15-20 part.
4. treatment pig cough illness as claimed in claim 3 and grippal Chinese medicine composition, it is characterized in that, described active component is made by 15 parts of 28 parts of the Rhizoma Anemarrhenaes, 13 parts of Herba Andrographis, 20 parts of Radix Ophiopogonis, 25 parts of Radix Scrophulariae, 13 parts of Flos Hibisci, 16 parts of Herba Lophatheris, 18 parts of Radix Platycodoniss, 26 parts of Radix Bupleuri, 18 parts of Spica Prunellaes, 28 parts of Flos Loniceraes, 27 parts of Fructus Forsythiaes, 28 parts of Radix Scutellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, Radix Glycyrrhizae.
5. such as claim 1-4 each described treatment pig cough illness and grippal Chinese medicine composition, it is pre-mixing agent, powder, powder, granule, oral liquid or injection.
6. the preparation method of each described treatment pig cough illness of claim 1-5 and grippal Chinese medicine composition comprises the steps:
1) takes by weighing by weight ratio each medicine material;
2) will claim each medicine material maybe will claim after pulverizing, sieving each medicine material through water or alcohol extraction, concentrated after, add again adjuvant or complementary composition that pharmacy can be used, be prepared from.
7. the preparation method for the treatment of pig cough illness as claimed in claim 6 and grippal Chinese medicine composition is characterized in that, described adjuvant is selected from one or more in dextrin, starch, lactose and the sucrose.
8. each described treatment pig cough illness of claim 1-5 and the grippal Chinese medicine composition application aspect preparation treatment cough illness and influenza medicine.
9. each described treatment pig cough illness of claim 1-5 and the grippal Chinese medicine composition application aspect preparation treatment cough illness and influenza feedstuff.
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| CN103829098A (en) * | 2014-03-18 | 2014-06-04 | 淮北正洋生物科技有限公司 | Pig feed for preventing cold and preparation method thereof |
| CN108902011A (en) * | 2018-04-25 | 2018-11-30 | 河池市宜州区群力种养专业合作社 | A kind of duroc cultural method |
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| CN1137400A (en) * | 1996-01-15 | 1996-12-11 | 贺力坤 | Method for preparation of drug for curing acute epidemic febrile disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103829098A (en) * | 2014-03-18 | 2014-06-04 | 淮北正洋生物科技有限公司 | Pig feed for preventing cold and preparation method thereof |
| CN108902011A (en) * | 2018-04-25 | 2018-11-30 | 河池市宜州区群力种养专业合作社 | A kind of duroc cultural method |
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Application publication date: 20130424 |