CN103041048B - Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same - Google Patents
Traditional Chinese medicine composition for treating animal enteritis and diarrhea and preparation method of same Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating animal enteritis or diarrhea and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the components in part by weight as follows: 25-50 parts of mongolian oak bark, 5-20 parts of figs, 5-20 parts of herba andrographitis, 2-12 parts of folium isatidis, 2-12 parts of desmodium triquetrum, 2-12 parts of red-knees herbs, 5-20 parts of herba portulacae and 5-15 parts of astragalus mongholicus. The traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis, detoxifying, detumescence, astringing and checking diarrhea and has obvious curative effects for animal enteritis or diarrhea. Clinical curative effect observations prove that the traditional Chinese medicine composition is rapid, reliable and authentic in curative effect for animal enteritis or diarrhea; and is non-toxic and harmless for animals, safe and reliable. In a clinical usage process, no untoward effects of the animals are observed, and the clinical usage is safe.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of animal enteritis or diarrhoea, relate in particular to a kind of Chinese medicine composition for the treatment of animal enteritis, diarrhoea and preparation method thereof that relates to, belong to the treatment by Chinese herbs field of animal enteritis, diarrhoea.
Background technology
The occurrence cause of animal enteritis is very complicated, mainly contains biological, toxic, several large classes of dystrophic; Biological paathogenic factor comprises virus, antibacterial, parasite or mycete etc.; Toxic reason is absorption or the interior metabolic poison producing of body of noxious substance; Trophism reason is mainly relevant with management discomfort with feedstuff, nutrition.Enteritis can be divided into acute, chronic two kinds by its process.Enteritis is very large for the harm of peltry animal, if effectively treated not in time, will cause animal dead.
Animal diarrhoea, especially the economic animal of peltry (such as fox, Nyctereutes procyonoides, mink etc.) diarrhoea, is a kind of commonly encountered diseases, frequently-occurring disease, epidemic diseases, is a long-term puzzlement raiser's a difficult problem.Peltry animal, because anti-stress ability is poor, has a large amount of fur-bearing animals to cause subtracting food because suffering from diarrhoea every year, thin and weak, and growth retardation is even dead, causes very large economic loss to raiser, is also a very stubborn problem for veterinary work person.Diarrhoea is a kind of animal especially economic animal to be endangered to serious disease, and M & M is high.Animal diarrhoea is the one performance in numerous disease process, in treatment, make a definite diagnosis difficulty, medication difficulty, easily repeatedly, refractory more, cause of disease more complicated, makes a definite diagnosis difficulty, easily causes mistaken diagnosis; And in digestive tract, useful microorganism is also suppressed in therapeutic process or kill, and the balance of normal microflora is damaged, thereby obstinate.In addition, stressors is many, causes the state of an illness sharply to increase the weight of, thereby has greatly increased this sick mortality rate.
The reason that causes animal diarrhoea is a lot, relates to virus, antibacterial, parasite and bait etc.Therefore, in production practices, control the economic animal diarrhoea property disease of the peltries such as fox, Nyctereutes procyonoides, mink, still have certain difficulty.
The Therapeutic Method of animal enteritis, diarrhoea has the methods such as the pharmacotherapy of antibiotherapy, fluid replacement therapy, endotoxin adsorbent therapy, anti-secretory drugs and inhibition intestinal tube wriggling conventionally.
Antibiotherapy is treatment animal enteritis, the most frequently used method of suffering from diarrhoea, to the enteritis being caused by antibacterial or viral infection, diarrhoea, use antibiotic to treat comparatively effective, there is instant effect, evident in efficacy, but also have that side effect is large simultaneously, the easy defect such as residual in body, need to use cautiously.For there is no antibacterial or viral infection, because variation has occurred the environment such as nutrition or temperature in intestinal, cause irritability diarrhoea or dystrophic diarrhoea that in intestinal, the environment of microorganism changes caused, can not use antibiotic therapy.
Chinese patent medicine has certain curative effect for the enteritis of animal, diarrhoea, but the existing Chinese patent medicine that is used for the treatment of animal enteritis or diarrhoea all in various degree exist slow, the defect such as curative effect is remarkable not that takes effect, have much room for improvement.
Summary of the invention
The present invention's technical problem first to be solved is Chinese medicine composition existing take effect slow, the inapparent defect of curative effect that overcomes existing treatment animal enteritis, diarrhoea, and the treatment animal enteritis of a kind of instant effect, determined curative effect, the Chinese medicine composition of diarrhoea are provided.
Another technical problem to be solved by this invention is to provide a kind of method of the Chinese medicine composition of preparing described treatment animal enteritis, diarrhoea.
Technical problem to be solved by this invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for animal enteritis, diarrhoea, comprise the component of following weight portion:
Cortex Querci Mongolicae 25-50 part, Fructus Fici 5-20 part, Herba Andrographis 5-20 part, Folium Isatidis 2-12 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 2-12 part, Herba polygoni hydropiperis 2-12 part, Herba Portulacae 5-20 part, Radix Astragali 5-15 part.
Preferably, the weight portion of each component is: Cortex Querci Mongolicae 35-50 part, Fructus Fici 5-15 part, Herba Andrographis 5-15 part, Folium Isatidis 3-6 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 3-6 part, Herba polygoni hydropiperis 3-6 part, Herba Portulacae 5-15 part, Radix Astragali 5-10 part.
Preferred, the weight portion of each component is: 40 parts of Cortex Querci Mongolicaes, 12 parts of Fructus Ficis, 12 parts of Herba Andrographis, 5 parts of Folium Isatidiss, 5 parts of Herba Desmodii Triquetri (Herba Tadehagi Triquetri)s, 5 parts of Herba polygoni hydropiperis, 12 parts of Herba Portulacaes, 8 parts of the Radixs Astragali.
Chinese medicine composition of the present invention is research and the Therapeutic Principle thereof of the deep layer pathogenesis to animal enteritis or diarrhoea based on inventor, simultaneously according to inventor's clinical experience and pharmaceutical research achievement for many years, filter out the crude drug of heat-clearing and toxic substances removing, astringing to arrest diarrhea, anti-inflammatory analgetic, form according to certain weight proportion prescription.
Cortex Querci Mongolicae: for Fagaceae oak belongs to the bark of deciduous tree plant Mongolian oak (Quercus mongolica Fisch.).Spring, autumn adopt, and scrape off outer rough bark, dry or cineration.Mildly bitter flavor, puckery; Property is put down.There is clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, effect of astringing to arrest diarrhea, can control the diseases such as dysentery.
Fructus Fici: be the fruit of Moraceae ficus species Fructus Fici Ficus carica L., its root and leaf are also used as medicine.Root can be adopted the whole year; Really, Ye Xiaqiucai, dry with or using fresh herb.Meridian distribution of property and flavor: really: sweet, flat.Root, leaf: light, puckery, flat.Function cures mainly: really: nourishing the lung to arrest cough, clearing away heat and moistening the bowels.For cough with asthma, laryngopharynx swelling and pain, constipation, hemorrhoid.Root, leaf: enteritis, diarrhoea; Carbuncle is controlled in external.
Herba Andrographis: be acanthaceous plant Herba Andrographis (Andrographis paniculata(Burm.f.) Nees) herb or leaf.Have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.Meridian distribution of property and flavor: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine, urinary bladder channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Cure mainly: cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom.
Folium Isatidis: the leaf of cruciferae isatis or branch and leaf.Property hardship, cold.Enter liver, the heart, stomach warp.Function cures mainly: heat clearing away, removing toxic substances, removing heat from blood, hemostasis.Control epidemic febrile disease intenseness of heat excessive thirst, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia, erysipelas, spits blood, epistaxis, jaundice, dysentery, sore throat, aphtha, swollen ulcer drug.
Herba Desmodii Triquetri (Herba Tadehagi Triquetri): pulse family beggar-ticks plant gourd tea Desmodium triquetrum(L.) DC., is used as medicine with Herb.Xia Qiu gathers, and cleans and chops up, and dries.Using fresh herb can be adopted at any time.Property micro-hardship, puckery, cool.Function cures mainly: heat-clearing and toxic substances removing, and removing food stagnancy dampness removing, parasite killing is anticorrosion.Be used for preventing heatstroke, cold, fever, laryngopharynx swelling and pain, nephritis, icterohepatitis, enteritis, bacillary dysentery, infantile malnutrition, vomiting during pregnancy, Fructus Ananadis comosi is poisoning, children's's scleroderma.
Herba polygoni hydropiperis: the dry herb of polygonaceae plant FUMAO knotweed Polygonum pubescens Blume.Summer, two seasons of autumn gather, and remove impurity, cleaning, drying.Property is pungent, temperature.Return lung, liver, large intestine channel.Function with cure mainly: removing toxic substances, damp eliminating, dissipating blood stasis, hemostasis.For dysentery, have loose bowels, tonsillitis, malaria, rheumatic arthralgia, treating swelling and pain by traumatic injury, metrorrhagia, carbuncle furuncle, scrofula, venom, eczema, tinea pedis, traumatic hemorrhage.
Herba Portulacae: another name: long life dish, longevity greens/mustard green, Wu Hangcao, hornet dish, Ma Macai.For the young young stem and leaf of portulacaceous plant Herba Portulacae.Cold in nature, sweet in the mouth acid; Enter the heart, liver, spleen, large intestine channel.Effect: heat-clearing and toxic substances removing, diuretic dries, loose blood detumescence, dust-collection sterilization, anti-inflammatory analgetic, hemostasis removing heat from blood.Cure mainly dysentery, enteritis, nephritis, puerperal, metrorrhagia, had blood in stool, the diseases such as mastitis.Loose blood detumescence, sharp intestinal habitual abortion, detoxifies treating stranguria, sweating due to debility after managing property.
The Radix Astragali: be the root of leguminous herbaceous plant's Radix Astagali, Radix Astragali.Property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The invigorating middle warmer of Radix Astragali Preparata QI invigorating, raw by consolidating superficial resistance holder skin ulcer.
In Chinese medicine composition object space of the present invention, Cortex Querci Mongolicae has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, and effect of astringing to arrest diarrhea, is monarch drug in side; Fructus Fici, Herba Andrographis and Herba Portulacae have effect of clearing away heat and moistening the bowels, removing toxic substances, removing heat from blood detumescence, anti-inflammatory analgetic, are ministerial drug in side; Effect that the Radix Astragali has and has benefiting QI for strengthening the superficies, arresting sweating is admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema, Folium Isatidis, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Herba polygoni hydropiperis and Herba Portulacae have effect of heat-clearing and toxic substances removing, anti-inflammatory analgetic, damp eliminating dissipating blood stasis, are the adjuvant in side altogether; In side of the present invention, each medicine compatibility is played effect of heat-clearing and toxic substances removing, astringing to arrest diarrhea, anti-inflammatory analgetic together altogether, has significant curative effect for enteritis or the diarrhoea of animal.Clinical observation on the therapeutic effect confirmation, Chinese medicine composition of the present invention is for the enteritis of animal or responding well to treatment soon of diarrhoea, and determined curative effect is reliable, true.Chinese medicine composition of the present invention is nontoxic for animal, safe and reliable, does not observe animal and occurs any untoward reaction, clinical use safety in use procedure.
Animal described in the present invention is preferably economic animal, for example, can be the economic animals such as fox, mink, Nyctereutes procyonoides.
The present invention's each taste crude drug used can be bought and obtain at pharmacy.
Various adjuvants required when medicine activity component of the present invention can add the dosage form of preparing oral formulations are prepared into any oral formulations that animal gavages that is suitable for clinically with conventional method of Chinese medicinal, for example, can be powder, granule or oral liquid etc.
Thus, the invention provides a kind of method of preparing described Chinese medicine composition, comprising:
(1) take each component by described weight portion;
(2) by each component mix homogeneously, pulverize, sieve (can be for example 60-800 mesh sieve, be preferably 80 orders), to obtain final product.
The another kind of preparation method of Chinese medicine composition of the present invention:
(1) take each component by described weight portion;
(2) component is pulverized and sieved to rear water and decoct, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, to obtain final product.
Wherein in step (2), each component is pulverized and sieved and boil 2-4 time with 3-8 times of weight decocting afterwards, decoct 1.5 hours at every turn.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factor such as diarrhoea degree and kind of concrete dosage form, animal.As guidance: for powder, the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 1g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Detailed description of the invention
Further describe the present invention below in conjunction with specific embodiment, advantage and disadvantage of the present invention will be more clear along with description.But these embodiment are only exemplary, scope of the present invention are not formed to any restriction.It will be understood by those skilled in the art that lower without departing from the spirit and scope of the present invention and can the details of technical solution of the present invention and form be modified or be replaced, but these amendments and replacement all fall within the scope of protection of the present invention.
The preparation of embodiment 1 powder
(1) take each component (unit: g): Cortex Querci Mongolicae 25, Fructus Fici 5, Herba Andrographis 5, Folium Isatidis 2, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 2, Herba polygoni hydropiperis 2, Herba Portulacae 5, the Radix Astragali 5 by described weight;
(2) by each component mix homogeneously, pulverize, cross 120 mesh sieves, to obtain final product.
The preparation of embodiment 2 powders
(1) take each component (unit: g): Cortex Querci Mongolicae 50, Fructus Fici 20, Herba Andrographis 20, Folium Isatidis 12, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 12, Herba polygoni hydropiperis 12, Herba Portulacae 20, the Radix Astragali 15 by described weight;
(2) by each component mix homogeneously, pulverize, cross 80 mesh sieves, to obtain final product.
The preparation of embodiment 3 powders
(1) take each component (unit: g): Cortex Querci Mongolicae 35, Fructus Fici 5, Herba Andrographis 5, Folium Isatidis 3, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 3, Herba polygoni hydropiperis 3, Herba Portulacae 5, the Radix Astragali 5 by described weight;
(2) by each component mix homogeneously, pulverize, cross 200 mesh sieves, to obtain final product.
The preparation of embodiment 4 powders
(1) take each component (unit: g): Cortex Querci Mongolicae 50, Fructus Fici 15, Herba Andrographis 15, Folium Isatidis 6, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 6, Herba polygoni hydropiperis 6, Herba Portulacae 15, the Radix Astragali 10 by described weight;
(2) by each component mix homogeneously, pulverize, cross 60 mesh sieves, to obtain final product.
The preparation of embodiment 5 powders
(1) take each component (unit: g): Cortex Querci Mongolicae 40, Fructus Fici 12, Herba Andrographis 12, Folium Isatidis 5, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 5, Herba polygoni hydropiperis 5, Herba Portulacae 12, the Radix Astragali 8 by described weight;
(2) by each component mix homogeneously, pulverize, cross 120 mesh sieves, to obtain final product.
The preparation of embodiment 6 granules
(1) take each component (unit: g): Cortex Querci Mongolicae 35, Fructus Fici 5, Herba Andrographis 5, Folium Isatidis 3, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 3, Herba polygoni hydropiperis 3, Herba Portulacae 5, the Radix Astragali 5 by described weight;
(2) by each component mix homogeneously, boil 3 times with the decocting of 6 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, after dry thick paste spraying, obtains dried cream powder, adds the adjuvant of preparations shaping, and granulation, to obtain final product.
The preparation of embodiment 7 granules
(1) take each component (unit: g): Cortex Querci Mongolicae 50, Fructus Fici 15, Herba Andrographis 15, Folium Isatidis 6, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 6, Herba polygoni hydropiperis 6, Herba Portulacae 15, the Radix Astragali 10 by described weight;
(2) by each component mix homogeneously, boil 2 times with the decocting of 8 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, after dry thick paste spraying, obtains dried cream powder, adds the adjuvant of preparations shaping, and granulation, to obtain final product.
The preparation of embodiment 8 granules
(1) take each component (unit: g): Cortex Querci Mongolicae 40, Fructus Fici 12, Herba Andrographis 12, Folium Isatidis 5, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 5, Herba polygoni hydropiperis 5, Herba Portulacae 12, the Radix Astragali 8 by described weight;
(2) by each component mix homogeneously, boil 3 times with the decocting of 5 times of weight, decoction liquor to be filtered, filtrate is condensed into thick paste, after dry thick paste spraying, obtains dried cream powder, adds the adjuvant of preparations shaping, and granulation, to obtain final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating animal of the present invention enteritis or diarrhoea
One, physical data: accepted 134 examples for medical treatment and suffer from the animal of acute enteritis or diarrhoea, wherein fox 50 examples, Nyctereutes procyonoides 28, mink 56 examples.The 134 routine animals of accepting for medical treatment all in various degree show that depressed, the loss of appetite of spirit, body temperature change, Excreta is thin medicated porridge sample, oil sample, water sample, be mixed with pus, intestinal mucosa, blood etc., meet Clinical Acute enteritis or diarrhoea diagnostic criteria,
Two, trial drug
The medicine that embodiment of the present invention 1-8 is prepared.
Three, Therapeutic Method
Powder: for powder, the powder boiled water of getting it filled gavages after soaking, the corresponding 1kg infected animal of 1g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Granule: for granule, get after granule boiled water soaks and gavage, the corresponding 1kg infected animal of 1g medicated powder body weight; Every day 2 times, 3 days is a course for the treatment of, treats 2 courses for the treatment of.
Four, efficacy assessment standard
Efficacy assessment standard and foundation:
Recovery from illness: treat after 1 course for the treatment of, acute enteritis or symptom of diarrhea disappear completely, and it is normal that function is recovered completely.
Remarkable: treat after 1 course for the treatment of, acute enteritis or symptom of diarrhea disappear substantially, and it is normal that function is recovered substantially.
Effective: treat after 2 courses for the treatment of, acute enteritis or symptom of diarrhea alleviate to some extent, and function is recovered to some extent.
Invalid: treat after 2 courses for the treatment of, acute enteritis or symptom of diarrhea and function are not improved.
Five, clinical observation result
Clinical observation result is in table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating animal of the present invention acute enteritis or diarrhoea
With the 2nd day of traditional Chinese medicine composition for treating animal of the present invention, acute enteritis or symptom of diarrhea that great majority are treated animal all had obviously and alleviate; Treat the 3rd day, acute enteritis or the symptom of diarrhea of being treated animal significantly improve; By the 5th day for the treatment of, the symptom of animal acute enteritis or diarrhoea disappeared substantially, and the every function of health recovers normal substantially.Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention is fast, evident in efficacy for responding well to treatment of the enteritis of animal or diarrhoea; In whole therapeutic process, do not observe the animal being treated and occur any untoward reaction, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (7)
1. treat the enteritis of mink, Nyctereutes procyonoides and fox, a Chinese medicine composition for diarrhoea, it is characterized in that, formed by each component of following weight portion: 40 parts of Cortex Querci Mongolicaes, 12 parts of Fructus Ficis, 12 parts of Herba Andrographis, 5 parts of Folium Isatidiss, 5 parts of Herba Desmodii Triquetri (Herba Tadehagi Triquetri)s, 5 parts of Herba polygoni hydropiperis, 12 parts of Herba Portulacaes, 8 parts of the Radixs Astragali.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that: be prepared into any mink, Nyctereutes procyonoides and fox acceptable suitable formulations clinically.
3. according to Chinese medicine composition claimed in claim 2, it is characterized in that: described preparation is oral formulations.
4. according to Chinese medicine composition claimed in claim 3, it is characterized in that: described oral formulations comprises powder, granule or oral liquid.
5. a method of preparing Chinese medicine composition described in claim 1, comprises the following steps:
(1) take each component by described weight portion;
(2) each component is pulverized, sieved, to obtain final product.
6. a method of preparing Chinese medicine composition described in claim 1, comprises the following steps:
(1) take each component by described weight portion;
(2) component is pulverized and sieved to rear water and decoct, decoction liquor is filtered, and filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, to obtain final product.
7. the purposes of Chinese medicine composition in enteritis or the diarrhoea medicine of preparation treatment mink, Nyctereutes procyonoides and fox described in claim 1.
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| CN103301385B (en) * | 2013-05-23 | 2015-05-06 | 辽宁农业职业技术学院 | Traditional Chinese medicine composition for treating animal diarrhea and preparation method thereof |
| CN104258328A (en) * | 2014-09-19 | 2015-01-07 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for treating mink viral enteritis and preparation method thereof |
| CN105079602B (en) * | 2015-09-11 | 2018-07-17 | 中国农业科学院特产研究所 | Treat the Chinese medicine composition and preparation method thereof of mink diarrhoeal diseases |
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| CN101297871A (en) * | 2007-08-31 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicinal composition for preventing and controlling enteritis of birds |
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| CN101297871A (en) * | 2007-08-31 | 2008-11-05 | 天津生机集团有限公司 | Chinese medicinal composition for preventing and controlling enteritis of birds |
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| Title |
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| 中医药治疗婴幼儿腹泻近况;孟宪凯等;《河北中医》;20020530;第24卷(第5期);388 * |
| 冷雪华灯.柞树皮及无花果治疗小儿腹泻136例.《中国民间疗法》.2004,第12卷(第6期),65. |
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