CN109954034A - A kind of preparation method for treating chill, wind-heat, the drug of influenza and its oral solution - Google Patents

A kind of preparation method for treating chill, wind-heat, the drug of influenza and its oral solution Download PDF

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CN109954034A
CN109954034A CN201910319095.6A CN201910319095A CN109954034A CN 109954034 A CN109954034 A CN 109954034A CN 201910319095 A CN201910319095 A CN 201910319095A CN 109954034 A CN109954034 A CN 109954034A
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parts
radix
rhizoma
influenza
cold
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张玉叶
刘光斌
王艳
毛琳
赵丽萍
毛和平
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Jiugang Hospital
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Jiugang Hospital
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The present invention proposes a kind of preparation method for treating chill, wind-heat, the drug of influenza and its oral solution, contains following component: schizonepeta, radix saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, radix bupleuri, the root of purple-flowered peucedanum, Rhizoma Chuanxiong, Fructus Aurantii, Poria cocos, rhizoma ligustici, radix scutellariae, almond, campanulaceae, Radix Glycyrrhizae.Preparation method: mixing, mixture add water to cook three times, and volatile oil is collected in decoction process；The filtrate that second and third secondary decoction is obtained merges, and is concentrated under reduced pressure, and sodium benzoate is added, and stands 24 hours, supernatant liquid filtering is taken, the volatile oil for decocting collection three times is added and decocts obtained filtrate for the first time, adds purified water, stirs evenly, packing sterilizes to get oral solution.The utility model has the advantages that cold symptoms can be eliminated rapidly, patient's pain is released in time, and have no toxic side effect, be the ideal medicament for treating anemofrigid cold, also have special efficacy to anemopyretic cold, influenza.It is that the patient of anemofrigid cold, anemopyretic cold and influenza this medicine is suitable for that can not argue out.

Description

A kind of preparation for treating chill, wind-heat, the drug of influenza and its oral solution Method
Technical field
The invention belongs to the field of Chinese medicines, it is related to treating the preparation of chill, wind-heat, the drug of influenza and its oral solution Method.
Background technique
Modern Chinese medicine treats the various informative of flu, curative for effect, and the research of traditional Chinese medicine treatment flu has been compared Deeply, all achieve certain achievement from Basic Theories of Chinese Medicine and clinical observation etc., traditional Chinese medicine to the etiology and pathogenesis of flu, Differentiation of symptoms and signs for classification of syndrome has unified standard and curative effect determinate standard substantially, and clinical classification is more clear, and clinic should reinforce the dialectical of flu The standardization of parting is studied.In addition we are, it is seen that traditional traditional Chinese medicine is playing it in current treatment method The Chinese materia medica preparation of unique therapeutic effect, research and development treatment flu will have broad application prospects, and increase this aspect It researchs and develops significant.
Flu is divided into plain edition flu, popular type flu, wind-cold type flu, anemopyretic cold, heat reason type sense by traditional Chinese and western medicine It emits.Cold symptoms caused by different reasons are roughly the same, but have individual difference, and medication difference is larger.Common cold is generally selected The analgesic-antipyretic etc. of symptomatic treatment, but will be based on supporting treatment, it is important to note that rest, great quantity of water drinking, the light battalion of diet It supports abundant.Popular type flu can the vaccine inoculation in 1-3 months before epidemic season, it is general only to make in important non-morbidity crowd With carrying out, once compound amantadine or anti virus herb can be selected in infection influenza, to be in addition isolated in early days and room in the fall Disinfection.Wind-cold type flu should be relieving the exterior syndrome with drugs pungent in flavor and warm in property based on sweating, drink ginger decoction in early days, symptom cannot be alleviated, and chill is selected Granules for treating common cold, anti-cold and heat-clearing electruary, Guizhi decoction etc. can also wash Saunas, soaking feet with hot water, more lid quilt sweatings, but avoid and use Lonicera and Forsythia The drugs such as Jiedu Tablets and SUNJU GANMAO PIAN.Anemopyretic cold mainly with relieving the exterior syndrome with drugs pungent in flavor and cool in property, selects anti-cold and febrifugal electuary, Radix Isatidis punching Agent, sanhuang tablets, sanhuang pian, swap buffers etc..But avoid with Notopterygii Bolus of Nine Ingredients, reason lung ball etc..Heat reason type flu, can be selected HuoXiangZhengQiShui, Lonicera and Forsythia Detoxifying pills etc. should not select Pachyma Compound Digestive Tonic Pill, stomach pill of aucklandia and amomum fruit etc. if the bowel symptoms of patient are heavier, if constitution is more empty to be selected Use bolus for reinforcing middle-jiao and replenishing qi.Clinically it is difficult to dialectical, especially doctor trained in Western medicine doctor in most cases to chill, wind-heat, influenza. The drug for the treatment of flu of the invention covers the cold symptoms of these three partings.
Clinically the patent medicine of common treatment flu is more at present, but passes through " State Food and Drug Administration " website Data query, the drug that forms of the present invention is not contained in market.
Summary of the invention
The purpose of the present invention is to propose to a kind of drugs for treating chill, wind-heat, influenza, while proposing the drug port Take the preparation method of liquid.
Technical solution of the present invention: a kind of drug for treating chill, wind-heat, influenza, in parts by weight, containing such as Lower component: 12-24 parts of schizonepeta, 12-24 parts of radix saposhnikoviae, 12-24 parts of Rhizoma Et Radix Notopterygii, 12-24 parts of Radix Angelicae Pubescentis, 12-24 parts of radix bupleuri, root of purple-flowered peucedanum 9-18 Part, 6-18 parts of Rhizoma Chuanxiong, 9-18 parts of Fructus Aurantii, 6-18 parts of Poria cocos, 6-15 parts of rhizoma ligustici, 12-24 parts of radix scutellariae, 9-21 parts of almond, campanulaceae 6- 18 parts, 3-9 parts of Radix Glycyrrhizae.
Further preferred number: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, the root of purple-flowered peucedanum 12 parts, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.
It is a kind of treat chill, wind-heat, influenza oral solution preparation method, weigh following drug by weight: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, Poria cocos 9 Said components are blended in one according to the number weighed up by part, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae It rises, mixture adds water to cook three times, decocts extracting in water 3 hours for the first time, amount of water is 4 times of mixture quality, is decocted Volatile oil is collected in journey, is filtered after decocting for the first time, filtrate and filter residue are obtained, and filter residue carries out second and decocts；Second of decoction Extracting in water 2 hours, amount of water was 10 times of mixture quality, and volatile oil is collected in decoction process, was filtered after second of decoction, Filtrate and filter residue are obtained, filter residue carries out third time decoction；Third time decocts extracting in water 2 hours, and amount of water is mixture quality 10 times, collect volatile oil in decoction process, third time filters after decocting, and obtains filtrate and filter residue；Second and third time is decocted The filtrate arrived merges, and sodium benzoate is added in reduced pressure, stands 24 hours, takes supernatant liquid filtering, is added and decocts collection three times Volatile oil and obtained filtrate is decocted for the first time, add purified water, stir evenly, dispensed, sterilize to get oral solution.
Prescription analysis: schizonepeta, windproof dispelling cold and removing dampness, benefiting qi for relieving superficies syndrome are had a headache for catching a cold in side；It is dissipated with Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis Chill, damp dispelling and pain relieving；Rhizoma Et Radix Notopterygii is longer than top wind-cold damp pathogen of dispelling, and Radix Angelicae Pubescentis is longer than lower part wind-cold damp pathogen of dispelling, and closes and uses it, controls one to lead to The common combinations of body wind-cold damp pathogen are altogether monarch drug in a prescription, are used for treating arthralgia due to cold and dampness that have a headache Xiang Qiang, few the moon volt wind headache, and chill holds wet head under the arm Bitterly.Rhizoma Chuanxiong, the rhizoma ligustici promoting flow of qi and blood circulation, and energy expelling wind and clearing away cold, dehumidify, analgesic, are used for anemofrigid cold, and pain, rheumatism numbness are pushed up in waist and knee, mountain peak Bitterly；Radix bupleuri expelling pathogenic factors from muscles and skin is thoroughly evil, and can promoting the circulation of qi, can principal drug assistance inducing diaphoresis by heresy, evacuation is brought down a fever, soothing liver-qi stagnation, lifting disease, for catching a cold Fever, fevers and chills alternate.Again can the promoting flow of qi and blood circulation reinforce diffusing impediment and relieving pain power, be all ministerial drug.Campanulaceae is pungent to be dissipated, and promoting the dispersing function of the lung benefit diaphragm is used for lung The cough and asthma of a surname's drop is lost, treatment chill is coughed up phlegm not well；The bitter temperature of Fructus Aurantii, regulating the flow of QI to ease the stomach match with campanulaceae, and one rise and one drop is unimpeded gas The common combinations of machine, wide chest benefit diaphragm.The root of purple-flowered peucedanum, semen armeniacae amarae promoting the circulation of qi resolving sputum are with cough-relieving；Poria cocos, radix scutellariae excreting dampness are with dissolving phlegm, resolving sputum, eliminating the phlegm It is all adjutant.Radix Glycyrrhizae harmonizing various medicinal property, and with QI invigorating in.
Therapeutic features: this drug is mainly by schizonepeta, radix saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, radix bupleuri, the root of purple-flowered peucedanum, Rhizoma Chuanxiong, Fructus Aurantii, Poria cocos, ligusticumic Sheet, radix scutellariae, semen armeniacae amarae, campanulaceae, Radix Glycyrrhizae composition, have the effect of relieving the exterior syndrome with drugs pungent in flavor and warm in property, promoting the dispersing function of the lung cold dispelling.For anemofrigid cold, headache hair Heat, aversion to cold bodily pain, thin nasal discharge.Anemofrigid cold is cured mainly, is had a headache and fever, aversion to cold bodily pain, thin nasal discharge, cough, dry throat person.Fang Zhong Schizonepeta, radix saposhnikoviae, Rhizoma Et Radix Notopterygii are pungent, tepor, inducing diaphoresis relieve heat, for catching a cold, have a headache.Radix Angelicae Pubescentis, Rhizoma Chuanxiong, rhizoma ligustici, pungent, bitter, tepor wind-dispelling removes Wet, numbness relieving and pain relieving is used for treating arthralgia due to cold and dampness, and pain, few the moon volt wind headache, headache caused by cold and dampness are pushed up in waist and knee, mountain peak.Radix bupleuri, evacuation are moved back Heat, soothing liver-qi stagnation, lifting disease.For cold, fever, fevers and chills alternate.Root of purple-flowered peucedanum semen armeniacae amarae campanulaceae is used for the cough and asthma of impairment of dispersing and descending function of the lung, Treatment chill is coughed up phlegm not well.Fructus Aurantii, Poria cocos, radix scutellariae promoting the circulation of qi resolving sputum, eliminating the phlegm.Radix Glycyrrhizae coordinating the drug actions of a prescription.Full side's treating both manifestation and root cause of disease, and with pungent Warm inducing diaphoresis, based on promoting the dispersing function of the lung cold dispelling, anemofrigid cold, aversion to cold bodily pain card type curative effect is best.
Beneficial effects of the present invention: 1. recipe composition is unique, through " gansu science and technology document shared platform " query display, not yet It was found that having formed identical person by with the drug；2. clinical efficacy is affirmed；3. inducing sweat and dispelling exogenous evils, relieve heat clearing damp, for treatment chill sense It emits, anemopyretic cold and influenza.4. enhance the dehumidifying of preparation, analgesic, the effect of opening lung-energy and anti-inflammatory, antiallergy, Anti-microbial effect.5. patient's immunity function can be enhanced, enhance the disease resistance of cold patients, and to frequent repeated cold Patient have good preventive and therapeutic action.6. cold symptoms can be eliminated rapidly, patient's pain, and nontoxic pair are released in time Effect is the ideal medicament for treating anemofrigid cold, also has special efficacy to anemopyretic cold, influenza.7. pharmacodynamic study also has There are the effects of significant antiviral, antibacterial, antipyretic, analgesia, anti-inflammatory, antibechic, treating both manifestation and root cause of disease.8. to can not argue out be anemofrigid cold, Anemopyretic cold and this medicine of the patient of influenza are suitable.
Specific embodiment
Embodiment 1
A kind of drug for treating chill, wind-heat, influenza contains following component: 15 parts of schizonepeta, radix saposhnikoviae in parts by weight 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, Huang 15 parts of a kind of reed mentioned in ancient books, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.
It is a kind of treat chill, wind-heat, influenza oral solution preparation method, weigh following drug by weight: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, Poria cocos 9 Said components are blended in one according to the number weighed up by part, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae It rises, mixture adds water to cook three times, decocts extracting in water 3 hours for the first time, amount of water is 4 times of mixture quality, is decocted Volatile oil is collected in journey, is filtered after decocting for the first time, filtrate and filter residue are obtained, and filter residue carries out second and decocts；Second of decoction Extracting in water 2 hours, amount of water was 4 times of mixture quality, and volatile oil is collected in decoction process, was filtered after second of decoction, Filtrate and filter residue are obtained, filter residue carries out third time decoction；Third time decocts extracting in water 2 hours, and amount of water is mixture quality 10 times, collect volatile oil in decoction process, third time filters after decocting, and obtains filtrate and filter residue；Second and third time is decocted The filtrate arrived merges, and sodium benzoate is added in reduced pressure, stands 24 hours, takes supernatant liquid filtering, is added and decocts collection three times Volatile oil and obtained filtrate is decocted for the first time, add purified water constant volume, stir evenly, dispensed, sterilize to get oral solution.
Embodiment 2
A kind of drug for treating chill, wind-heat, influenza contains following component: 18 parts of schizonepeta, radix saposhnikoviae in parts by weight 18 parts, 18 parts of Rhizoma Et Radix Notopterygii, 18 parts of Radix Angelicae Pubescentis, 18 parts of radix bupleuri, 15 parts of the root of purple-flowered peucedanum, 12 parts of Rhizoma Chuanxiong, 15 parts of Fructus Aurantii, 12 parts of Poria cocos, 12 parts of rhizoma ligustici, 18 parts of radix scutellariae, 15 parts of almond, 9 parts of campanulaceae, 6 parts of Radix Glycyrrhizae.
It is a kind of treat chill, wind-heat, influenza oral solution preparation method, weigh following drug by weight: 18 parts of schizonepeta, windproof 18 parts, 18 parts of Rhizoma Et Radix Notopterygii, 18 parts of Radix Angelicae Pubescentis, 18 parts of radix bupleuri, 15 parts of the root of purple-flowered peucedanum, 12 parts of Rhizoma Chuanxiong, 15 parts of Fructus Aurantii, Poria cocos 12 parts, 12 parts of rhizoma ligustici, 18 parts of radix scutellariae, 15 parts of almond, 9 parts of campanulaceae, 6 parts of Radix Glycyrrhizae mix said components according to the number weighed up Together, mixture adds water to cook three times, decocts extracting in water 3 hours for the first time, and amount of water is 4 times of mixture quality, decocts Volatile oil is collected during boiling, is filtered after decocting for the first time, filtrate and filter residue are obtained, and filter residue carries out second and decocts；Second It decocts extracting in water 2 hours, amount of water is 10 times of mixture quality, volatile oil is collected in decoction process, after second decocts Filtering, obtains filtrate and filter residue, and filter residue carries out third time decoction；Third time decocts extracting in water 2 hours, and amount of water is mixture 10 times of quality collect volatile oil in decoction process, third time filters after decocting, and obtain filtrate and filter residue；By two, three times decoct Obtained filtrate merges, and is concentrated under reduced pressure, and sodium benzoate is added, and stands 24 hours, takes supernatant liquid filtering, is added to decoct three times and collect Volatile oil and obtained filtrate for the first time, add purified water, stir evenly, dispense, sterilize to get oral solution.
The preparation of embodiment 3(pill) 24 parts of schizonepeta, windproof 24 parts, 24 parts of Rhizoma Et Radix Notopterygii, 24 parts of Radix Angelicae Pubescentis, 24 parts of radix bupleuri, the root of purple-flowered peucedanum 18 parts, 15 parts of Rhizoma Chuanxiong, 15 parts of Fructus Aurantii, 12 parts of Poria cocos, 12 parts of rhizoma ligustici, 24 parts of radix scutellariae, 18 parts of almond, 12 parts of campanulaceae, 9 parts of Radix Glycyrrhizae.
A kind of drug for treating chill, wind-heat, influenza contains following component in parts by weight: 24 parts of schizonepeta, Windproof 24 parts, 24 parts of Rhizoma Et Radix Notopterygii, 24 parts of Radix Angelicae Pubescentis, 24 parts of radix bupleuri, 18 parts of the root of purple-flowered peucedanum, 15 parts of Rhizoma Chuanxiong, 15 parts of Fructus Aurantii, 12 parts of Poria cocos, rhizoma ligustici 12 parts, 24 parts of radix scutellariae, 18 parts of almond, 12 parts of campanulaceae, 9 parts of Radix Glycyrrhizae.A kind of oral solution for treating chill, wind-heat, influenza Preparation method, weigh following drug by weight: 15 parts of schizonepeta, 15 parts of radix saposhnikoviae, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, Said components are mixed according to the number weighed up, are crushed, sieving is prepared into pill
The preparation of embodiment 4(granule)
A kind of drug for treating chill, wind-heat, influenza contains following component: 15 parts of schizonepeta, radix saposhnikoviae in parts by weight 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, Huang 15 parts of a kind of reed mentioned in ancient books, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.It is a kind of treat chill, wind-heat, influenza oral solution preparation side Method weighs following drug: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, the root of purple-flowered peucedanum 12 by weight Part, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, will be above-mentioned Component is mixed according to the number weighed up, is crushed, and sieving is prepared into granule.
The preparation of embodiment 5(powder)
A kind of drug for treating chill, wind-heat, influenza contains following component: 15 parts of schizonepeta, radix saposhnikoviae in parts by weight 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, Huang 15 parts of a kind of reed mentioned in ancient books, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.It is a kind of treat chill, wind-heat, influenza oral solution preparation side Method weighs following drug: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, the root of purple-flowered peucedanum 12 by weight Part, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, will be above-mentioned Component is mixed according to the number weighed up, is crushed, and sieving is prepared into powder.
The preparation of embodiment 6(tablet)
A kind of drug for treating chill, wind-heat, influenza contains following component: 15 parts of schizonepeta, radix saposhnikoviae in parts by weight 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, Huang 15 parts of a kind of reed mentioned in ancient books, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.It is a kind of treat chill, wind-heat, influenza oral solution preparation side Method weighs following drug: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, the root of purple-flowered peucedanum 12 by weight Part, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, will be above-mentioned Component is mixed according to the number weighed up, is crushed, and sieving is prepared into tablet.
The preparation of embodiment 7(capsule)
A kind of drug for treating chill, wind-heat, influenza contains following component: 15 parts of schizonepeta, radix saposhnikoviae in parts by weight 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, Huang 15 parts of a kind of reed mentioned in ancient books, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.It is a kind of treat chill, wind-heat, influenza oral solution preparation side Method weighs following drug: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, the root of purple-flowered peucedanum 12 by weight Part, 10 parts of Rhizoma Chuanxiong, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, will be above-mentioned Component is mixed according to the number weighed up, is crushed, and sieving is prepared into capsule.
Clinical efficacy explanation: Jiayuguan is located in West Part of Gansu, the most west section of Hexi Corridor, number extremely frigid zones, chill sense The disease incidence emitted is relatively high, based on this Gansu Province Jiayuguan Jiu Gang hospital by constantly groping, screening, develops of the invention Medicine oral liquid, said preparation original is with decoction at clinical use 8 years, and respectively with card type, gender, age, course of disease grouping observation is summarized In January, 2009 into December 1029 in 2016, male 639, women 390, the age 7 years old -81 years old, average age 33.9 Year.Treatment results: curing 675, accounts for 65.60%, improves 329, occupies 32.0%, invalid 25, accounts for 2.4%, clinical data warp Statistical procedures show that the course of disease is short, and good effect, the age is positively correlated with the course for the treatment of.Total effective rate 97.6%, the affirmative by patient And favorable comment.The advantages that after being prepared into oral solution, without patient's decoction, tool is easy to take, easy to carry, and curative effect is affirmed.Now by this Oral solution clinical observation on the therapeutic effect is summarized as follows
Object and method
The all the court's division of respiratory diseases of patient are seen and treated patients and the dialectical flu seen and treated patients from September, 2013 in September, 2018 of holding a consultation of department of traditional Chinese medicine Patient.Meet following condition: 1. Western medicine diagnostic criteria: meeting the diagnostic criteria of " practical clinical practice " acute upper respiratory infection. 2. tcm diagnosis standard: meeting " new Chinese medicine guideline of clinical investigations ", " disease of tcm Standardization of diagnosis and curative effect " chill, wind Heat, the diagnostic criteria of influenza.3. patient cooperates treatment method.4. exclusion criteria: having used therapeutic agent Person such as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever；With pharynx-conjunctivitis, suppurative tonsillitis person；Merge Other primary disease persons of lung, such as pulmonary tuberculosis, lung swelling and pain person；Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person； The gestational period, breast feeding women and system allergy sufferers；WBC>10×109/L；Mental patient.
108 outpatient service cold patients for meeting above-mentioned condition to be collected altogether, meet above-mentioned standard, body temperature is no more than 39 DEG C of persons, The course of disease is within 48h, and the age is between 13~65 years old.Be randomly divided into 2 groups by random number method: treatment group is 25, female 27 male； Average age (37.33 ± 13.18) year；Head examines body temperature (38.65 ± 0.45) DEG C.Control group male 24, female 28；Average age (36.67 ± 11.03) year；Head examines body temperature (38.56 ± 0.43) DEG C.Two groups are examined body temperature through statistics in gender, average age, head Processing, no significant difference (P> 0.05), it is comparable.
Treatment method
Treatment group's Primary Care: taking a good rest, and bland diet is drunk more water, while taking orally the anti-solution sense oral solution of chaste tree of the invention, first 2 secondary (total 20mL is prepared with the formula of embodiment 1, preparation method), later 1 (10mL, with the formula of embodiment 1, preparation method every time Preparation), 3 times a day.
Control group Primary Care: taking a good rest, and bland diet is drunk more water, while oral paracetamol caffein atificial cow-bezoar, 2 tablets each time, 3 times a day；Ribavirin tablet, each 0.15g, 3 times a day.
Two groups of curative effect is 3d.
Observation index part: sneeze, nasal obstruction, runny nose；Constitutional symptom: fever with aversion to cold, headache, malasia.
Curative effect judging standard is drafted referring to flu criterion of therapeutical effect in " new Chinese medicine guideline of clinical investigations " flu.It fullys recover from an illness More: clinical symptoms, sign disappear or mostly disappear, syndrome integral reduce >=95%；Effective: clinical symptoms, sign are obviously improved, Syndrome integral reduces >=70%；Effective: clinical symptoms, sign take a favorable turn, syndrome integral >=30%；It is invalid: clinical symptoms, sign It is not improved, even aggravating, syndrome integral is reduced less than 30%.
Statistical method uses 20.0 statistical software of SPSS, and mean compares between two groups is examined using t, and enumeration data uses Rank sum test；The comparison of two sample rates uses χ2It examines.
As a result the cardinal symptom that cardinal symptom improvement situation compares treatment group is obviously improved compared with control group, and difference has statistics Meaning (P< 0.05).It is shown in Table 1.
1 cardinal symptom of table improves situation and compares (example)
Note: all symptom treatment groups are compared with the control groupP< 0.05
The comparison of clinical efficacy takes orally the recovery from illness number of the treatment group of the anti-solution sense oral solution of chaste tree of the invention more than control group, treatment group Total effective rate is 92.59%, control group effective percentage be 77.78%, treatment group's curative effect be better than control group, difference it is statistically significant (P < 0.05).It is shown in Table 2.
2 Clinical efficacy comparison of table (example)
Group Number of cases Recovery from illness It is effective Effectively In vain Total effective rate
Treatment group 54 32 11 7 4 92.59%
Control group 54 23 13 5 13 75.93%
Note: treatment group is compared with the control groupP< 0.05
Typical case
Case 1: Feng Nvshi, 19 years old, Jiayuguan wine steel hospital personnel, because weather cools down suddenly, heating stopped, in 2018 years 4 When month afternoon 4 on the 6th, cause to catch a cold in cold room operation, symptom are as follows: nasal obstruction, runny nose be clear, sneeze, dry throat, pharynx itch, are low voice speaking, Cough, sputum are thin, 39.1 DEG C of fever without perspiration, body temperature, aversion to cold, headache, Muscular stiffness, indigestion and loss of appetite, white and greasy fur, floating pulse or floating Number.About in fall ill 16 2018 hour morning 9 on the 7th in April when take chaste tree of the invention anti-solution sense oral solution 2 (20mL, with The formula of embodiment 1, preparation method preparation), 1 (10mL is prepared with the formula of embodiment 1, preparation method) every time later, three times a day, in Taking oral solution of the invention second day, (on April 8th, 2018) morning, symptom was alleviated substantially, took altogether 6 times, April 9 in 2018 Day cold symptoms are cured completely.
Case 2: Fan Tongxue, female, 12 years old, 6 classman of Jiayuguan highway inside buildings primary school.Afternoon on October 21st, 2018 Islam room suffers from cold again and causes to catch a cold after school has physical education perspiration when 3.Symptom are as follows: nasal obstruction, runny nose are clear, pharynx itches, is low voice speaking, cough Cough, sputum it is thin, fever, 39.3 DEG C of body temperature, aversion to cold, headache, Muscular stiffness are indigestion and loss of appetite.It is anti-that chaste tree of the invention is taken when next day 9 Solution sense oral solution 1 (10mL is prepared with the formula of embodiment 1, preparation method), later 1 (10mL, with matching for embodiment 1 every time Side, preparation method preparation), three times a day, in (on October 23rd, 2018) remission in morning of taking oral solution of the invention second day, Take altogether 6 times, on October 24th, 2018 cold symptoms cure completely.
Case 3: Sun Xiansheng, 25 years old, Jiayuguan wine steel hospital personnel was being done later due to perspiring during working labour It dries and causes to catch a cold in public room.Symptom are as follows: headache, nasal obstruction, runny nose be clear, sneeze, low voice speaking, cough, sputum are thin, fever, body temperature 38.7 DEG C, aversion to cold, muscle arthrosis are ached, taken when disease sends out next day 10 the anti-solution of chaste tree of the invention feel oral solution 1 (10mL, with The formula of embodiment 1, preparation method preparation), 1 (10mL is prepared with the formula of embodiment 1, preparation method) every time later, three times a day, in It takes oral solution the next morning symptom of the invention to be alleviated, take altogether 9 times, cold symptoms are cured completely.
Case 4: Kang Nvshi, 65 years old, won block resident for Jiayuguan.It is jumped when the May in 2018 of afternoon 4 on the 16th in park Square dance is perspired, and undressing to suffer from cold after going home causes to catch a cold.Symptom are as follows: headache, nasal obstruction, runny nose is clear, pharynx itches, is low voice speaking, cough, phlegm Liquid is thin, and fever, 38.6 DEG C of body temperature, aversion to cold, Muscular stiffness are indigestion and loss of appetite.It is oral that chaste tree of the invention anti-solution sense is taken when next day 20 Liquid 2 (20mL is prepared with the formula of embodiment 1, preparation method), later 1 (10mL, with the formula of embodiment 1, preparation method system every time It is standby), three times a day, in taking oral solution of the invention second day, (on May 18th, 2018) morning, symptom was alleviated, and took altogether 10 times, on May 22nd, 2018 cold symptoms cure completely.
Case 5: Guo Xiansheng, male, 23 years old, Jiayuguan wine steel hospital personnel, on November 12nd, 2018 was in influenza Period contacts frequently with cold patients, infected to cause to catch a cold.Symptom are as follows: headache, nasal obstruction, runny nose is clear, sheds tears, is low voice speaking, cough, Fever, 38.1 DEG C of body temperature, it is aversion to cold, Muscular stiffness, out of strength, anti-solution sense oral solution 2, chaste tree of the invention are taken when disease sends out next day 9 (20mL, with the formula of embodiment 1, preparation method prepare), later every time 1 (10mL, with the formula of embodiment 1, preparation method prepare), one It 3 times, is alleviated in the oral solution the next morning symptom for taking of the invention, taken altogether 9 times, cold symptoms are cured completely.
The main relieving the exterior syndrome with drugs pungent in flavor and warm in property of the present invention, promoting the dispersing function of the lung cold dispelling, clearing damp.It is gone to for " influenza ", anemofrigid cold, anemofrigid cold later period Anemopyretic cold, have a headache and fever lossless, aversion to cold bodily pain, muscle arthrosis are ached, thin nasal discharge, cough, dry throat, white and greasy fur, arteries and veins Floating or floating number person.We also can be used for dysentery, sore carbuncle from the beginning of and the person that has exterior cold syndrome.

Claims (5)

1. a kind of drug for treating chill, wind-heat, influenza, it is characterized in that: in parts by weight, containing following component: chaste tree 12-24 parts of mustard, 12-24 parts of radix saposhnikoviae, 12-24 parts of Rhizoma Et Radix Notopterygii, 12-24 parts of Radix Angelicae Pubescentis, 12-24 parts of radix bupleuri, 9-18 parts of the root of purple-flowered peucedanum, Rhizoma Chuanxiong 6-18 Part, 9-18 parts of Fructus Aurantii, 6-18 parts of Poria cocos, 6-15 parts of rhizoma ligustici, 12-24 parts of radix scutellariae, 9-21 parts of almond, 6-18 parts of campanulaceae, Radix Glycyrrhizae 3-9 Part.
2. a kind of drug for treating chill, wind-heat, influenza according to claim 1, it is characterized in that: with parts by weight Meter contains following component: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, Rhizoma Chuanxiong 10 Part, 12 parts of Fructus Aurantii, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae.
3. the drug for the treatment of chill according to claim 1 or 2, wind-heat, influenza, it is characterized in that: routinely Method of Chinese medicinal is prepared into any common oral preparation of Chinese traditional medicinal.
4. the drug for the treatment of chill according to claim 3, wind-heat, influenza, it is characterized in that: the oral system Agent is one of oral solution, pill, granule, powder, tablet, capsule.
5. it is a kind of treat chill, wind-heat, influenza drug oral solution preparation method, it is characterized in that: claiming by weight Take following drug: 15 parts of schizonepeta, windproof 15 parts, 15 parts of Rhizoma Et Radix Notopterygii, 15 parts of Radix Angelicae Pubescentis, 15 parts of radix bupleuri, 12 parts of the root of purple-flowered peucedanum, 10 parts of Rhizoma Chuanxiong, trifoliate orange 12 parts of shell, 9 parts of Poria cocos, 9 parts of rhizoma ligustici, 15 parts of radix scutellariae, 12 parts of almond, 9 parts of campanulaceae, 5 parts of Radix Glycyrrhizae, by said components according to weighing up Number mixes, and mixture adds water to cook three times, decocts extracting in water 3 hours for the first time, amount of water is mixture quality 4 times, collect volatile oil in decoction process, filtered after decocting for the first time, obtain filtrate and filter residue, filter residue carries out second and decocts It boils；Second decocts extracting in water 2 hours, and amount of water is 10 times of mixture quality, collects volatile oil in decoction process, and second It is filtered after secondary decoction, obtains filtrate and filter residue, filter residue carries out third time decoction；Third time decocts extracting in water 2 hours, amount of water It is 10 times of mixture quality, volatile oil is collected in decoction process, third time filters after decocting, and obtains filtrate and filter residue；By Two, the filtrate decocted three times merges, and is concentrated under reduced pressure, and sodium benzoate is added, and stands 24 hours, takes supernatant liquid filtering, is added The volatile oil of collection is decocted three times and decocts obtained filtrate for the first time, adds purified water constant volume, stirs evenly, and is dispensed, sterilizing, i.e., Obtain oral solution.
CN201910319095.6A 2019-04-19 2019-04-19 A kind of preparation method for treating chill, wind-heat, the drug of influenza and its oral solution Pending CN109954034A (en)

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN111888403A (en) * 2020-09-01 2020-11-06 蚌埠市畜牧兽医技术推广站 Liquid medicine for treating wind-cold of broiler chicken and preparation method thereof
CN114073730A (en) * 2020-08-14 2022-02-22 鲁南制药集团股份有限公司 Traditional Chinese medicine composition for preventing or treating air-conditioning syndrome
CN115518102A (en) * 2021-05-30 2022-12-27 山东新时代药业有限公司 Traditional Chinese medicine composition with cold resisting function

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Title
张巧丽等: "败毒散临床应用体会", 《河南中医》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114073730A (en) * 2020-08-14 2022-02-22 鲁南制药集团股份有限公司 Traditional Chinese medicine composition for preventing or treating air-conditioning syndrome
CN111888403A (en) * 2020-09-01 2020-11-06 蚌埠市畜牧兽医技术推广站 Liquid medicine for treating wind-cold of broiler chicken and preparation method thereof
CN115518102A (en) * 2021-05-30 2022-12-27 山东新时代药业有限公司 Traditional Chinese medicine composition with cold resisting function

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