CN118512570A - Traditional Chinese medicine composition for treating epigastric pain, external application patch and application thereof - Google Patents
Traditional Chinese medicine composition for treating epigastric pain, external application patch and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating epigastric pain, which comprises the following components in parts by weight: 8-12 parts of rheum officinale, 2-5 parts of borneol, 7-12 parts of galangal, 7-12 parts of rhizoma cyperi, 12-18 parts of ligusticum wallichii and 8-12 parts of rhizoma zingiberis. The invention also provides an external application patch for treating epigastric pain, which comprises a carrier and active ingredients, wherein the content of the active ingredients accounts for 40-50% of the total mass, and the active ingredients are the traditional Chinese medicine composition for treating the epigastric pain. The external application patch for treating epigastric pain can achieve the purpose of preventing and treating diseases by sticking the medicament on local tissues (acupuncture points) of a human body, can effectively treat the epigastric pain, and has no side effect.
Description
Technical Field
The invention relates to the technical field of external medicines, in particular to a traditional Chinese medicine composition for treating epigastric pain, an external application patch and application thereof.
Background
The incidence rate of the general population of chronic gastritis is high, and the incidence rate of patients with upper gastrointestinal symptoms can reach 71.4-83.3%. In 2011, a cross-sectional investigation is performed by the department of gastroenterology of the Chinese medical society, and the research shows that among various chronic gastritis, chronic non-atrophic gastritis with erosion and chronic atrophic gastritis are more common. Clinical symptoms of chronic gastritis are pain in the upper abdomen, abdominal distension, early satiety, belching, diet reduction, or burning sensation in the upper abdomen. The symptoms lack of specificity, the diagnosis depends on gastroscopy and endoscopic pathological examination, and the symptoms belong to the categories of epigastric pain, distention and fullness in the traditional Chinese medicine and the like.
Along with the gradual aggravation of senile people, epigastric pain and distention and fullness in the aged people are increased, the most common oral medicament for treating chronic gastritis at present is Proton Pump Inhibitor (PPI), but long-term oral administration of the PPI brings risk of intestinal flora imbalance and even pathological fracture to the aged, so that a safe and effective epigastric pain treatment medicament is needed.
Disclosure of Invention
The invention aims to solve the technical problem of providing the medicine for treating the epigastric pain, which can achieve the purpose of preventing and treating diseases, can effectively treat the epigastric pain and has no side effect.
The first aspect of the invention provides a traditional Chinese medicine composition for treating epigastric pain, which comprises the following components in parts by weight:
8-12 parts of rheum officinale, 2-5 parts of borneol, 7-12 parts of galangal, 7-12 parts of rhizoma cyperi, 12-18 parts of ligusticum wallichii and 8-12 parts of rhizoma zingiberis.
Further, the traditional Chinese medicine composition for treating epigastric pain comprises the following components in parts by weight: 10 parts of rheum officinale, 3 parts of borneol, 9 parts of galangal, 9 parts of rhizoma cyperi, 15 parts of ligusticum wallichii and 10 parts of ginger.
The second aspect of the invention provides an external application patch for treating epigastric pain, which comprises a carrier and active ingredients, wherein the content of the active ingredients is 40-50% of the total mass, and the active ingredients are the traditional Chinese medicine composition for treating the epigastric pain in the first aspect. Wherein, the content of the active ingredients can be: 40%, 45% or 50% of the total mass, and correspondingly the carrier content is 60%, 55% or 50% of the total mass.
Further, the carrier is vaseline.
Further, the dosage of the external application patch is 5-6 g/dose.
Further, the preparation method of the external application patch comprises the following steps:
pulverizing each component in the effective components, mixing, and sieving with 80-100 mesh sieve to obtain mixture;
adding vaseline in proportion, and stirring to obtain topical patch for treating epigastralgia.
The third aspect of the invention provides an application of a traditional Chinese medicine composition for treating epigastric pain in treating epigastric pain digestive diseases.
In a fourth aspect, the present invention provides an external application for treating epigastric pain, and the application is used for treating epigastric pain digestive diseases.
Compared with the prior art, the traditional Chinese medicine composition for treating epigastric pain, the external application patch and the application thereof have the beneficial effects that:
1. The traditional Chinese medicine composition for treating epigastric pain provided by the invention has the advantages that galangal and rhizoma cyperi are monarch drugs, qi circulation and cold expelling and pain relieving, liver soothing and stomach harmonizing are carried out, rheum officinale and ligusticum wallichii are ministerial drugs, qi circulation and depression relieving functions are carried out in an auxiliary way, the depression relieving is carried out in the middle, ginger is an adjuvant drug, stomach harmonizing and vomiting relieving are carried out, borneol is a guiding drug, and the guiding drug is used for transdermal meridian restoration and directly reaches the disease site. The whole formula has the effects of promoting qi circulation, resolving stagnation, relieving pain, harmonizing stomach and preventing vomiting.
2. The external application patch for treating epigastric pain is an external application, and the external application patch is stuck on local tissues (acupuncture points) of a human body to achieve the purpose of preventing and treating diseases, so that the external application patch has no toxic or side effect.
Detailed Description
In order to better understand the technical solution in the embodiments of the present invention and make the above objects, features and advantages of the present invention more obvious and understandable, the following detailed description of the present invention will be further described.
The endpoints and any values of the ranges disclosed herein are not limited to the precise range or value, and are understood to encompass values approaching those ranges or values. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and should be considered as specifically disclosed herein.
The invention relates to a traditional Chinese medicine composition for treating epigastric pain, which comprises the following components in parts by weight:
8-12 parts of rheum officinale, 2-5 parts of borneol, 7-12 parts of galangal, 7-12 parts of rhizoma cyperi, 12-18 parts of ligusticum wallichii and 8-12 parts of rhizoma zingiberis.
The formula comprises the following components:
Rhubarb: enters stomach, large intestine and liver meridian. Soup materia medica (soup materia Medica): "get in hand, foot yangming channel". "; compendium, compendium: five meridians and blood-distribution of hand and foot jueyin. "; ben Cao Jing Jie (materia Medica solution): the small intestine meridian and the heart meridian of hand shaoyin. The triple energizer meridian of hand shaoyang is combined with stomach meridian of foot yang and large intestine meridian of hand yang. Purging heat toxin, removing accumulation and stagnation, and promoting blood stasis. For constipation due to excessive heat, delirium, distention and fullness in the chest and abdomen, early stage of dysentery, tenesmus, stasis and amenorrhea, abdominal mass, epidemic heat syndrome, red and painful eyes, hematemesis, epistaxis, yellow yang, edema, stranguria with turbid urine, carbuncle, ulcer and swelling, furuncle, and fire-induced injury. Purging heat, removing heat from the intestines, cooling blood, removing toxin, removing blood stasis and dredging channels. Can be used for treating constipation due to excessive heat, abdominal pain due to stagnation, diarrhea, and jaundice due to damp-heat. Book of changes: the food is prepared by the steps of removing blood stasis, blood closure, cold and heat, breaking the mass, retaining food retention, washing intestines and stomach, promoting aging to get new, dredging the food ('food' is used as 'water Gu Dao'), regulating the middle warmer, dissolving food, and regulating the five viscera. The miscellaneous records: stomach-calming, qi-descending, phlegm-excess eliminating, heat accumulation in the intestine, fullness in the heart and abdomen, cold blood obstruction and distention in women, lower abdominal pain, and blood retention of the old. ". Drug Property theory (L): the Chinese medicinal composition has effects of resolving food stagnation, promoting digestion, regulating five zang organs, dredging female menstruation, promoting edema, eliminating excessive phlegm, accumulating cold and heat, resolving food stagnation, promoting large and small intestine, and treating toxic heat swelling, and can be used for treating infantile cold and heat diseases, dysphoria, pus erosion, and blood retention.
Borneol: pungent, bitter and slightly cold. It enters heart, spleen and lung meridians. Promoting the flow of qi, inducing resuscitation, removing stagnated fire, removing nebula, improving eyesight, and relieving swelling and pain. For vomiting at middle wind gap, fever, coma, convulsion, epilepsy, phlegm-fan, deafness due to qi-obstruction, sore throat, aphtha, otitis media, carbuncle, hemorrhoids, nebula, enterobiasis. Tang Ben Cao (Tang Ben Cao): pathogenic qi in the heart and abdomen, wind-dampness accumulation and deafness. Improving eyesight, removing conjunctival congestion and nebula. Compendium, compendium: treating sore throat, headache, nasal obstruction, odontalgia, typhoid fever, tongue appearance and infantile acne. Unblocking orifices and dispelling stagnated fire.
Galangal: pungent and hot. Enter spleen and stomach meridians. Warming stomach, expelling wind, expelling cold, promoting qi circulation and relieving pain. For cold in spleen and stomach, cold pain in stomach and abdomen, vomiting and diarrhea, dysphagia and regurgitation, food stagnation, malaria, cold addiction, etc.: mainly sudden cold, cold in stomach, reverse cold, cholera and abdominal pain. ". Drug Property theory (L): for chronic cold in the waist, adverse flow of stomach-qi and vomiting. Treating wind, breaking qi, abdominal cold pain; dispel wind-cold arthralgia, treat heart-cold regurgitation, abdominal pain, vomiting and diarrhea. ". The "materia Medica pickup Yi": descending qi and tonifying sound. It is decocted for drinking to treat dysentery and cholera. ". Japanese Sunji (Japanese Subtu) grass: for diarrhea and dysentery, regurgitation, vomiting and food retention. ".
And (3) rhizoma cyperi: pungent, slightly bitter, slightly sweet, and flat. It enters liver, spleen and triple energizer meridians. Regulate qi, resolve depression, alleviate pain and regulate menstruation. For liver and stomach disharmony, qi depression, distending pain in chest, abdomen, hypochondrium, distention and fullness due to phlegm-fluid retention, irregular menstruation, metrorrhagia and metrostaxis. Regulating qi and resolving stagnation: can be used for treating chest and hypochondrium pain and gastralgia due to stagnation of liver-qi. Bupleuri radix and pericarpium Citri Reticulatae viride are used to treat chest and hypochondrium pain. For stomach cold pain, it is combined with Gao Liang Jiang (Ming Liang Fu Wan). Yunnan Ben Cao (materia Medica): regulating qi in blood, resolving depression, resolving food stagnation, and relieving emesis. ". Compendium, compendium: "dispelling cold and epidemic disease, li Sanjiao, relieving six depression, eliminating food and beverage accumulation, phlegm and fluid fullness, tarsal swelling, abdominal distention, beriberi, pain of heart and abdomen, limbs, head, eyes, teeth and ears, carbuncles and sores, hematemesis, hematuria, metrorrhagia and metrostaxis of women, irregular menstruation and puerperal diseases.
Ligusticum wallichii: the Chinese medicinal composition has the effects of invigorating liver, gall bladder and pericardium meridian, promoting blood circulation and removing blood stasis; promoting qi circulation and resolving stagnation; dispelling wind and relieving pain. Materia medica Hui Yan: Xiong Qiong, a drug for ascending the head and eyes, regulating menstruation, resolving stagnation in the middle-jiao and blood and qi. For the patients who have the actions of treating blood, it is the herb that is used by Dang Gui, but it is also used for treating qi. It can dispel cold and dampness, remove wind and qi, improve eyesight, relieve headache and wind, remove hypochondriac pain, nourish fetus before and after, and treat obstruction of blood, pain and itch and sore, carbuncle, cold and heat, debility and arthralgia, swelling and pain. Flavor Xin Xingyang, qi moving well without yin coagulation and viscosity, but entering blood system, it can remove all wind and regulate all qi.
Ginger: pungent and slightly warm. Enter lung, spleen and stomach meridians. Relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomiting, eliminating phlegm, relieving cough, and relieving fish and crab toxicity. The materia medica is from new: ginger juice, with the functions of resolving phlegm, treating dysphagia, regurgitation, saving die of a sudden illness, treating bromhidrosis and freezing ears. Roast ginger and arrest vomiting. Medical mirror about meeting ]: roasted ginger, rhizoma Zingiberis recens, for treating stomach cold, diarrhea and acid regurgitation. "Qianjin-food therapy: "sweat, bad smell on diaphragm" is removed.
The traditional Chinese medicine composition provided by the invention has the following compatibility principle: galangal and nutgrass galingale rhizome are monarch drugs, qi-moving, cold-dispelling, pain-relieving, liver-soothing, stomach-harmonizing, rheum officinale and ligusticum wallichii are ministerial drugs, the efficacy of moving qi and resolving depression is assisted, the middle-jiao is used as an adjuvant drug, ginger is used as an stomach-harmonizing, vomiting-relieving drug, borneol is used as an guiding drug, and the drug is introduced into the skin to enter the channel directly. The whole formula has the effects of promoting qi circulation, resolving stagnation, relieving pain, harmonizing stomach and preventing vomiting.
The traditional Chinese medicine composition provided by the invention is used as an external application patch. The external application patch for treating epigastric pain comprises a carrier and active ingredients, wherein the carrier is Vaseline, the content of the active ingredients accounts for 40-50% of the total mass, and the active ingredients comprise the following components in parts by weight:
8-12 parts of rheum officinale, 2-5 parts of borneol, 7-12 parts of galangal, 7-12 parts of rhizoma cyperi, 12-18 parts of ligusticum wallichii and 8-12 parts of rhizoma zingiberis.
The following describes in detail the Chinese medicinal composition and the external application patch for treating epigastric pain according to the present invention by way of specific examples.
Example 1
A traditional Chinese medicine composition for treating epigastric pain comprises the following components in parts by weight:
10 parts of rheum officinale, 3 parts of borneol, 9 parts of galangal, 9 parts of rhizoma cyperi, 15 parts of ligusticum wallichii and 10 parts of ginger.
Example 2
A traditional Chinese medicine composition for treating epigastric pain comprises the following components in parts by weight:
8 parts of rheum officinale, 2 parts of borneol, 7 parts of galangal, 7 parts of rhizoma cyperi, 12 parts of ligusticum wallichii and 8 parts of ginger.
Example 3
A traditional Chinese medicine composition for treating epigastric pain comprises the following components in parts by weight:
12 parts of rheum officinale, 5 parts of borneol, 12 parts of galangal, 12 parts of nutgrass galingale rhizome, 18 parts of ligusticum wallichii and 12 parts of ginger.
Example 4
An external application patch for treating epigastric pain comprises the following components in percentage by weight:
50% of active ingredients and 50% of carriers;
wherein the carrier is vaseline, and the formula of the effective component is as in example 1.
In this example, the preparation method of the external application patch for treating epigastric pain is as follows:
Firstly, crushing and mixing various components in the active ingredients, and sieving the crushed and mixed components with a 80-100-mesh sieve to obtain a mixture;
then adding vaseline according to a certain proportion, and uniformly stirring to obtain the external application patch.
In the embodiment, the external application patch is a patch pill, and the specification of the pill is 5-6 g/pill.
The external application patch for treating epigastric pain of example 4 was subjected to clinical test, and the test method and results are as follows:
(1) Case selection
80 Cases of epigastric pain patients in 2022-2023 of some middle hospital in Hunan were selected.
(2) Diagnostic criteria: standard of Chinese medicine symptoms
(3) Exclusion criteria
① Less than the eighteen years of age or more than 50 years of age; ② Allergic constitution or people allergic to the medicine; ③ Acute gastric ulcer patient; ④ Combining malignant tumor and gastrointestinal hemorrhage; ⑤ Patients with severe other systemic primary diseases and mental disorders.
(4) Therapeutic method
The external application patch of example 4 was applied to the points of the Liangmen, zusanli and Zhongwan, and the point application was left for 8 hours or more once a day for a week, and the treatment conditions of each patient were recorded. And re-diagnosing in one month after treatment, recording and observing laboratory examination indexes and scoring scales, and evaluating the effectiveness and safety of treatment.
(5) Observation index
Therapeutic index: symptom improvement rate = (total pre-treatment integral-total post-treatment integral)/total pre-treatment and post-treatment integral × 100%
Safety index: measuring blood pressure and heart rate; blood and urine are regular; electrocardiogram, liver function (ALT), kidney function (BUN, scr).
(6) Efficacy assessment criteria
The related diagnosis principle and the disease condition severity standard of epigastric pain in the Chinese medicine New medicine clinical research guiding principle of the national medicine administration are referred to, and the clinical control, the obvious effect, the effective effect and the ineffective effect are classified according to the index improvement condition.
Clinical control: the main symptoms disappear, and the integral of symptoms is reduced by more than 90%.
The effect is shown: the main symptoms disappear, and the integral of symptoms is reduced by 60-89%.
The method is effective: the main symptoms are improved, and the integral of symptoms is reduced by 30-59%.
Invalidation: the main symptoms and various indexes are not obviously changed or aggravated, and the integral of symptoms is reduced by less than 30 percent.
(7) Statistical method
After the clinical data collection is completed, all the data are built into a database. Statistical analysis was performed using the professional statistical software package SPSS 25.0. The measurement data are described by mean and standard deviation (x+/-s), the difference comparison is carried out by selecting independent sample t test conforming to normal distribution, and the rank sum test (Mann-Whitney U test) is adopted for the measurement data with non-normal distribution; the counting data adopts rank sum test and chi-square test. Assuming that the test uses a two-sided test uniformly, the test statistics and the corresponding P values are given, and P <0.05 is taken as significance statistics meaning.
(8) Results
Case completion: 80 patients observe in one month after treatment, 5 patients fall off, the effective rate is 26.6 percent (20 patients), the effective rate is 53.3 percent (40 patients), the inefficiency rate is 20 percent, and the total effective rate is 80 percent.
Adverse event incidence adverse reaction occurs in 1 case of treatment group during treatment, because the applied part is reddish and skin is allergic; the adverse reaction rate is 1.3% (1/75), and the blood pressure, heart rate, blood routine, renal function and electrocardiographic examination result before and after the rest treatment are compared, so that no obvious change is found.
In summary, the external application patch for treating epigastric pain can effectively improve symptoms, improve the overall life quality of patients, and has the advantages of maintained curative effect, clinical safety and effectiveness.
The embodiments of the present invention have been described in detail above, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention.
Claims (8)
1. The traditional Chinese medicine composition for treating epigastric pain is characterized by comprising the following components in parts by weight:
8-12 parts of rheum officinale, 2-5 parts of borneol, 7-12 parts of galangal, 7-12 parts of rhizoma cyperi, 12-18 parts of ligusticum wallichii and 8-12 parts of rhizoma zingiberis.
2. The traditional Chinese medicine composition for treating epigastric pain according to claim 1, which is characterized by comprising the following components in parts by weight:
10 parts of rheum officinale, 3 parts of borneol, 9 parts of galangal, 9 parts of rhizoma cyperi, 15 parts of ligusticum wallichii and 10 parts of ginger.
3. An external application patch for treating epigastric pain is characterized by comprising a carrier and active ingredients, wherein the content of the active ingredients accounts for 40-50% of the total mass, and the active ingredients are the traditional Chinese medicine composition for treating epigastric pain according to claim 1 or 2.
4. The external application patch for treating epigastric pain according to claim 3, wherein the carrier is vaseline.
5. A topical application for treating epigastric pain according to claim 3, wherein the topical application is a pill, the specification of the pill is 5-6 g/pill.
6. The external application patch for treating epigastric pain according to claim 3, wherein the external application patch is prepared by the following method:
pulverizing each component in the effective components, mixing, and sieving with 80-100 mesh sieve to obtain mixture;
adding vaseline in proportion, and stirring to obtain topical patch for treating epigastralgia.
7. Use of the Chinese medicinal composition for treating epigastric pain according to claim 1 in treating epigastric pain digestive diseases.
8. Use of the external application patch for treating epigastric pain according to claim 3 for treating digestive diseases of epigastric pain.
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