CN101347548A - Oral preparation for treating headache and preparation method - Google Patents
Oral preparation for treating headache and preparation method Download PDFInfo
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- CN101347548A CN101347548A CNA2008100550701A CN200810055070A CN101347548A CN 101347548 A CN101347548 A CN 101347548A CN A2008100550701 A CNA2008100550701 A CN A2008100550701A CN 200810055070 A CN200810055070 A CN 200810055070A CN 101347548 A CN101347548 A CN 101347548A
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Abstract
The invention provides an oral preparation for treating headache, which can be prepared into tablets, granules, capsules or water pills and includes the raw materials with the following parts by weight: 200-500 parts of hemlock parsley, 300-500 parts of baked white peony root, 200-500 parts of angelica dahurica, 30-50 pars of scorpion, 30-50 parts of centipede, 20-60 parts of piper longum, 50-160 parts of stiff silkworm, 60-120 parts of baked licorice, 120-180 parts of viter rotundifolia, 100-160 parts of Chinese ligusticum rhizome, 24-35 parts of asarum, 100-160 parts of rhizoma corydalis, 80-120 parts of bupleurum, 60-80 parts of mint and 20-53 parts of pharmaceutical excipient. Based on numerous experiments, the oral preparation tentatively utilizes the Chinese medicines with the functions of dispelling wind, clearing orifices, activating blood circulation and alleviating pains for treating migraine, relaxing blood vessels, relieving vasospasm, lowing vascular resistance and improving microcirculation; proved by animal experiment study, the extract of the oral preparation of the oral preparation has strong analgesic function on the rat migraine model caused by glonoin and good analgesic function on the animal models treated with mechanical stimulus, chemical stimulation and thermal stimulus and can significantly improve the blood rheological property of the rabbits of blood stasis models. The oral preparation of the invention has low cost and is suitable for mass production.
Description
Technical field
The present invention relates to a kind of treatment especially migrainous oral formulations of headache and preparation method, belong to the oral preparation of Chinese traditional medicinal technical field.
Background technology
The fast pace of modern metropolitan cities life forces people to drop among the nervous working and learning, and headache has become the high disease of a kind of sickness rate.Especially migraine (Migraine) be a kind of outbreak repeatedly, the severe headache of one or both sides pulsation, during outbreak with heart rate quickening, pale complexion, feel sick, vomiting etc., tendencys such as blurred vision, flash of light, hemianopsia are often arranged before the outbreak.It is long that migraine has the course of disease, and intermittence is shown effect repeatedly, delays characteristics such as difficulty heals, and caused great misery to the patient, always is considered as difficult and complicated illness by doctor family.Since the nineties in last century, a series of treatment migraine remedies have been developed abroad, be mainly triptan, ergotoxine bases and beta-blocker etc., but more toxic and side effects is arranged in clinical use, The World Health Organization (WHO) is thought, the severe migraine occupies preceding 20 of internal disease of the modal people's of making disablement, and the Chinese medicine migraine has certain advantage at aspects such as reducing the headache seizure frequency and the degree that eases the pain, and its drug safety is easily accepted by the patient.
Summary of the invention
The objective of the invention is on a large amount of experimental basis, inquire into and use the key promoting blood circulation and stopping pain treatment by Chinese herbs migraine clearly of dispeling the wind, vasodilator, alleviating vascular spasm, reduction vascular resistance, microcirculation improvement is developed the oral formulations of effective, with low cost, as to be suitable for large-scale production treatment by Chinese herbs headache.
The technical scheme that the present invention provides is: the oral formulations of this treatment headache comprises that following raw medicaments in portion by weight makes tablet, granule, capsule or watered pill:
Rhizoma Chuanxiong 200-500 Radix Paeoniae Alba (processed) 300-500 Radix Angelicae Dahuricae 200-500 Scorpio 30-50 Scolopendra 30-50 Fructus Piperis Longi 20-60 Bombyx Batryticatus 50-160 Radix Glycyrrhizae Preparata 60-120 pharmaceutic adjuvant 20-53.
The oral formulations of described treatment headache also comprises following weight portion during crude drug is formed:
Fructus Viticis 120-180 Rhizoma Ligustici 100-160 Herba Asari 24-35 Rhizoma Corydalis 100-160 Radix Bupleuri 80-120 Herba Menthae 60-80.
The oral formulations of described treatment headache, make 1000 in tablet by the crude drug of following weight:
This 120g of Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 120g Fructus Viticis 120g Gao Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g pharmaceutic adjuvant 37g.
The oral formulations of described treatment headache, make 1000 in tablet by the crude drug of following weight:
Rhizoma Chuanxiong 200g Radix Paeoniae Alba 200g Radix Angelicae Dahuricae 200g Fructus Viticis 180g Rhizoma Ligustici 160g Herba Asari 25g Rhizoma Corydalis 160g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 49g.
The oral formulations of described treatment headache, make 1000 in tablet by the crude drug of following weight:
Rhizoma Chuanxiong 500g Radix Paeoniae Alba 500g Radix Angelicae Dahuricae 500g Fructus Viticis 180g Rhizoma Ligustici 160g Herba Asari 35g Rhizoma Corydalis 160g Radix Bupleuri 120g Scorpio 30g Scolopendra 30g Fructus Piperis Longi 25g Bombyx Batryticatus 50g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 53g.
The oral formulations of described treatment headache, make 1000 of capsules by the crude drug of following weight:
Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 400g Fructus Viticis 120g Rhizoma Ligustici 120g Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g pharmaceutic adjuvant 37g.
The oral formulations of described treatment headache, make granule 250 bags by following raw medicaments in portion by weight:
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 120g Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 154g.
The oral formulations of described treatment headache, make 1000 of watered pill by following raw medicaments in portion by weight:
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 100g Herba Asari 25g Rhizoma Corydalis 100g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 49g.
The oral formulations of described treatment headache, it is prepared as follows:
A, get Scorpio, Scolopendra, Bombyx Batryticatus and be ground into fine powder, standby;
B, get Fructus Piperis Longi, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Bupleuri and Rhizoma Ligustici etc. 5 flavor medicines and decoct with water 3 times, add 8 times of water gagings for the first time and decocted 2 hours; Add for the second time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings for the third time and decocted 1 hour, merge decoction liquor, filter, the filtrate standing over night is got supernatant, is condensed into 1: 1 extractum, and is standby;
C, get Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Fructus Viticis, Herba Asari, Rhizoma Corydalis 6 flavor pulverizing medicinal materials and become coarse powder, spend the night, add 10 times again and measure 75% alcohol reflux twice with 1 times of 5% heavy soak with ethanol of medical material, each 2 hours, merge extractive liquid, was evaporated to relative density and is 1.30～1.35 thick paste, add the fine powder of steps A and the extractum of step B, mixing, drying is pulverized, sieve, add the pharmaceutic adjuvant mixing, granulate drying with 65% syrup;
D, make tablet, granule, capsule or watered pill.
Be principal agent with the Rhizoma Chuanxiong in this product of the present invention prescription, Xin Xianghang looses, and warm promoting blood circulation is the gas medicine in the blood, has the effect of pain-relieving powder wind, promoting blood circulation and stopping pain, grasps because of it and rises a diffusing property, can go upward to the head, so for controlling the key medicine of headache; The Radix Paeoniae Alba pain relieving of nourishing blood, stagnating in the promoting the circulation of blood of holding concurrently; Reach on the Radix Angelicae Dahuricae fragrance, can lead to nine orifices; The Fructus Viticis bitter in the mouth is flat, the clear sharp head of the double energy of the wind pain relieving of loosing; Fructus Piperis Longi is hot goes into Yangming Channel, and for controlling the key medicine of headache, nasal sinusitis, toothache, itself and the Radix Paeoniae Alba 5 cloudy blood of growing are mutually removed the stagnation of QI.The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.We skilful use Herba Menthae is compared with Flos Chrysanthemi with other side's heat clearing away is many, and the merit of the sharp clearly head, soothing the liver circulation of qi promoting is arranged, Herba Menthae lightly float rise floating, should with compatibilities such as Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, through sick institute.Go into Liver Channel again, compatibility Radix Bupleuri depressed liver-energy dispersing and QI regulating is innovative point of the present invention.Make a general survey of full side, diffusing wind of the addiction of dispelling and removing obstruction in the collateral to relieve pain are laid equal stress on, and have the merit of the lucid yang sending up that nourishes blood, giving consideration to both the incidental and fundamental concurrently.
Animal experiment study shows that oral formulations combined extracts of the present invention causes the rat Nerve in Migraine Model to nitroglycerin very strong analgesic activity; Mechanical stimulus, chemical stimulation, thermostimulation animal pattern all there is good analgesic activity; Can obviously improve the hemorheological property of blood stasis model rabbit, have certain function of promoting blood circulation to disperse blood clots; Cerebral blood flow increasing amount to a certain extent after the administration reduces cerebral vascular resistance; But combined extracts endothelium-dependent relaxation ground diastole isolated rat thoracic aorta obviously resists the inductive vasoconstriction effect of KCl.
The present invention utilizes methods such as decocting boils, alcohol reflux that the different material medicine is extracted according to the physicochemical property of medical material effective ingredient, farthest extracts the effective ingredient of medical material, and animal drugs adopts full crude drug powder to be used as medicine, and has farthest kept its curative effect.The present invention adopts modern crafts and equipment to produce, be prepared into oral formulations such as coated tablet, granule, capsule or watered pill, trade name is easy to carry for " headache root of Dahurian angelica convulsion sheet (ball, capsule, granule etc.) ", the bitterness and the fishy smell of medicine have been covered, easily preserve, satisfy patient's the requirement of taking medicine, helped industrialized great production.
The specific embodiment
Treat the example of the preparation of tablet, capsule, granule in the oral formulations of headache below in conjunction with the present invention, the specific embodiment of the present invention and purposes are described.
Embodiment 1 headache root of Dahurian angelica convulsion sheet
The component part by weight
This 120g of Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 120g Fructus Viticis 120g Gao Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g
Pharmaceutic adjuvant: calcium hydrogen phosphate or calcium carbonate 25g low-substituted hydroxypropyl cellulose 7g magnesium stearate 5g
Preparation method:
1) get Scorpio, Scolopendra, Bombyx Batryticatus and be ground into fine powder, standby;
2) get 5 flavor medicines such as Fructus Piperis Longi, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Bupleuri and Rhizoma Ligustici and decoct with water 3 times, add 8 times of water gagings for the first time and decocted 2 hours; Add for the second time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings for the third time and decocted 1 hour, merge decoction liquor, filter, the filtrate standing over night is got supernatant, is condensed into 1: 1 extractum, and is standby;
3) get 6 flavor pulverizing medicinal materials such as Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Fructus Viticis, Herba Asari, Rhizoma Corydalis and become coarse powder, spend the night, add twice of 10 times of amount 75% alcohol reflux again with 1 times of 5% heavy soak with ethanol of medical material, each 2 hours, merge extractive liquid, was evaporated to relative density and is 1.30～1.35 thick paste, add the fine powder of steps A and the extractum of step B, mixing, drying is pulverized, sieve, add the calcium hydrogen phosphate mixing, granulate drying with 65% syrup;
4) add low-substituted hydroxypropyl cellulose and magnesium stearate and make 1000, adopt commercially available film coating pre-mix dose bag film-coat, perhaps sugar coating.
Embodiment 2 headache root of Dahurian angelica convulsion sheets
The component part by weight:
Rhizoma Chuanxiong 200g Radix Paeoniae Alba 200g Radix Angelicae Dahuricae 200g Fructus Viticis 180g Rhizoma Ligustici 160g Herba Asari 25g Rhizoma Corydalis 160g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g
Pharmaceutic adjuvant: calcium carbonate 25g carboxymethyl starch sodium 12g magnesium stearate 4g Pulvis Talci 8g.
Preparation method: with embodiment 1 1) 2) 3), 4) add carboxymethyl starch sodium and magnesium stearate is made 1000.
Embodiment 3 headache root of Dahurian angelica convulsion sheets
The component part by weight:
Rhizoma Chuanxiong 500g Radix Paeoniae Alba 500g Radix Angelicae Dahuricae 500g Fructus Viticis 180g Rhizoma Ligustici 160g Herba Asari 35g Rhizoma Corydalis 160g Radix Bupleuri 120g Scorpio 30g Scolopendra 30g Fructus Piperis Longi 25g Bombyx Batryticatus 50g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g
Pharmaceutic adjuvant: calcium carbonate 25g carboxymethyl starch sodium 16g magnesium stearate 4g Pulvis Talci 8g.
Preparation method: with embodiment 2.
Embodiment 3 headache root of Dahurian angelica convulsion capsules
The component part by weight
Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 400g Fructus Viticis 120g Rhizoma Ligustici 120g Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g
Pharmaceutic adjuvant: calcium hydrogen phosphate 25g Pulvis Talci 10g
Preparation method:
With embodiment 1 1) 2) 3), 4) encapsulated 1000.
Embodiment 4 headache root of Dahurian angelica convulsion granules
The component part by weight
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 120g Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g
Pharmaceutic adjuvant: calcium hydrogen phosphate 25g dextrin 100g Icing Sugar 2gg
Preparation method:
With embodiment 1 1) 2) 3), 4) packing granule 250 bag.
Embodiment 5 headache root of Dahurian angelica convulsion balls
The component part by weight
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 100g Herba Asari 25g Rhizoma Corydalis 100g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g
Pharmaceutic adjuvant: calcium carbonate 25g carboxymethyl starch sodium 10g starch 14g
Preparation method:
With embodiment 1 1) 2), needn't granulate after the step 3) medicament mixed, directly be equipped with 1000 of the watered pills with watered pill mechanism.
The foregoing description is used to prepare the oral formulations of treatment headache clinically, formulation method can be routinely preparation technology, for example, the preparation process of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record, make the acceptable any conventional dosage form of pharmaceutics, for example tablet, granule, capsule, buccal tablet, concentrated pill, drop pill etc.For described dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Listed examples of the present invention is intended to further illustrate formulation method of the present invention and application direction, and scope of the present invention is not constituted any restriction.
Claims (8)
1, a kind of oral formulations for the treatment of headache is characterized in that: comprise that following raw medicaments in portion by weight makes tablet, granule, capsule or watered pill:
Rhizoma Chuanxiong 200-500 Radix Paeoniae Alba (processed) 300-500 Radix Angelicae Dahuricae 200-500 Fructus Viticis 120-180
Rhizoma Ligustici 100-160 Herba Asari 24-35 Rhizoma Corydalis 100-160 Radix Bupleuri 80-120
Scorpio 30-50 Scolopendra 30-50 Fructus Piperis Longi 20-60 Bombyx Batryticatus 50-160 Herba Menthae 60-80
Radix Glycyrrhizae Preparata 60-120 pharmaceutic adjuvant 20-53.
2, the oral formulations of treatment headache according to claim 1 is characterized in that: make 1000 in tablet by the crude drug of following weight:
This 120g of Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 120g Fructus Viticis 120g Gao
Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g
Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g pharmaceutic adjuvant 37g.
3, the oral formulations of treatment headache according to claim 1 is characterized in that: make 1000 in tablet by the crude drug of following weight:
Rhizoma Chuanxiong 200g Radix Paeoniae Alba 200g Radix Angelicae Dahuricae 200g Fructus Viticis 180g Rhizoma Ligustici 160g
Herba Asari 25g Rhizoma Corydalis 160g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g
Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 49g.
4, the oral formulations of treatment headache according to claim 1 is characterized in that: make 1000 in tablet by the crude drug of following weight:
Rhizoma Chuanxiong 500g Radix Paeoniae Alba 500g Radix Angelicae Dahuricae 500g Fructus Viticis 180g Rhizoma Ligustici 160g
Herba Asari 35g Rhizoma Corydalis 160g Radix Bupleuri 120g Scorpio 30g Scolopendra 30g
Fructus Piperis Longi 25g Bombyx Batryticatus 50g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 53g.
5, the oral formulations of treatment headache according to claim 1 is characterized in that: make 1000 of capsules by the crude drug of following weight:
Rhizoma Chuanxiong 400g Radix Paeoniae Alba (processed) 400g Radix Angelicae Dahuricae 400g Fructus Viticis 120g Rhizoma Ligustici 120g
Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 48g Scolopendra 48g
Fructus Piperis Longi 24g Bombyx Batryticatus 80g Herba Menthae 80g Radix Glycyrrhizae Preparata 80g pharmaceutic adjuvant 37g.
6, the oral formulations of treatment headache according to claim 1 is characterized in that: make granule 250 bags by following raw medicaments in portion by weight:
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 120g
Herba Asari 24g Rhizoma Corydalis 120g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g
Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 154g.
7, the oral formulations of treatment headache according to claim 1 is characterized in that: make 1000 of watered pill by following raw medicaments in portion by weight:
Rhizoma Chuanxiong 300g Radix Paeoniae Alba (processed) 300g Radix Angelicae Dahuricae 300g Fructus Viticis 120g Rhizoma Ligustici 100g
Herba Asari 25g Rhizoma Corydalis 100g Radix Bupleuri 80g Scorpio 50g Scolopendra 50g
Fructus Piperis Longi 25g Bombyx Batryticatus 80g Herba Menthae 60g Radix Glycyrrhizae Preparata 60g pharmaceutic adjuvant 49g.
8, according to the oral formulations of the described treatment headache of each claim of claim 1-7, it is characterized in that it is prepared as follows:
A, get Scorpio, Scolopendra, Bombyx Batryticatus and be ground into fine powder, standby;
B, get Fructus Piperis Longi, Herba Menthae, Radix Glycyrrhizae Preparata, Radix Bupleuri and Rhizoma Ligustici 5 flavor medicines decoct with water 3 times, add 8 times of water gagings for the first time and decocted 2 hours; Add for the second time 8 times of water gagings and decocted 2 hours, add 6 times of water gagings for the third time and decocted 1 hour, merge decoction liquor, filter, the filtrate standing over night is got supernatant, and the dense extractum that shortens 1: 1 into is standby;
C, get Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Angelicae Dahuricae, Fructus Viticis, Herba Asari, Rhizoma Corydalis 6 flavor pulverizing medicinal materials and become coarse powder, spend the night, add 10 times again and measure 75% alcohol reflux twice with 1 times of 5% heavy soak with ethanol of medical material, each 2 hours, merge extractive liquid, was evaporated to relative density and is 1.30～1.35 thick paste, add the fine powder of steps A and the extractum of step B, mixing, drying is pulverized, sieve, add the pharmaceutic adjuvant mixing, granulate drying with 65% syrup;
D, make tablet, granule, capsule or watered pill.
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| CNA2008100550701A CN101347548A (en) | 2008-06-16 | 2008-06-16 | Oral preparation for treating headache and preparation method |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102018768A (en) * | 2010-12-24 | 2011-04-20 | 广东药学院 | Traditional Chinese medicine used for curing migraine |
| CN101612207B (en) * | 2009-07-16 | 2011-09-07 | 刘玉兰 | Traditional Chinese medicine for treating headache and preparation method thereof |
| CN104758346A (en) * | 2015-04-23 | 2015-07-08 | 邵勇 | Medicine for treating migraine, as well as preparation method and preparation of medicine |
| CN105582189A (en) * | 2016-02-24 | 2016-05-18 | 李莉 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN107308274A (en) * | 2017-08-02 | 2017-11-03 | 何茂蕾 | A kind of Toutongning capsule for headache |
| CN110327444A (en) * | 2019-07-17 | 2019-10-15 | 无锡市中医医院 | Treat migraine rhizome of chuanxiong root of Dahurian angelica Chinese medicine compound prescription, capsule, pill and powder and preparation method |
| CN111226863A (en) * | 2020-02-25 | 2020-06-05 | 赵永烈 | Modeling method of wind-heat migraine model rat and obtained model rat |
| CN111494560A (en) * | 2020-05-20 | 2020-08-07 | 江苏省中医院 | Compound preparation for treating liver wind internal stirring type migraine and preparation method and application thereof |
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2008
- 2008-06-16 CN CNA2008100550701A patent/CN101347548A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101612207B (en) * | 2009-07-16 | 2011-09-07 | 刘玉兰 | Traditional Chinese medicine for treating headache and preparation method thereof |
| CN102018768A (en) * | 2010-12-24 | 2011-04-20 | 广东药学院 | Traditional Chinese medicine used for curing migraine |
| CN102018768B (en) * | 2010-12-24 | 2011-12-07 | 广东药学院 | Traditional Chinese medicine used for curing migraine |
| CN104758346A (en) * | 2015-04-23 | 2015-07-08 | 邵勇 | Medicine for treating migraine, as well as preparation method and preparation of medicine |
| CN105582189A (en) * | 2016-02-24 | 2016-05-18 | 李莉 | Traditional Chinese medicine preparation for treating cerebral concussion and preparation method thereof |
| CN107308274A (en) * | 2017-08-02 | 2017-11-03 | 何茂蕾 | A kind of Toutongning capsule for headache |
| CN110327444A (en) * | 2019-07-17 | 2019-10-15 | 无锡市中医医院 | Treat migraine rhizome of chuanxiong root of Dahurian angelica Chinese medicine compound prescription, capsule, pill and powder and preparation method |
| CN111226863A (en) * | 2020-02-25 | 2020-06-05 | 赵永烈 | Modeling method of wind-heat migraine model rat and obtained model rat |
| CN111494560A (en) * | 2020-05-20 | 2020-08-07 | 江苏省中医院 | Compound preparation for treating liver wind internal stirring type migraine and preparation method and application thereof |
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Application publication date: 20090121 |