CN101190283B - Medicine for treating cervical vertebra disease - Google Patents

Medicine for treating cervical vertebra disease Download PDF

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CN101190283B
CN101190283B CN2006101458440A CN200610145844A CN101190283B CN 101190283 B CN101190283 B CN 101190283B CN 2006101458440 A CN2006101458440 A CN 2006101458440A CN 200610145844 A CN200610145844 A CN 200610145844A CN 101190283 B CN101190283 B CN 101190283B
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Abstract

The invention relates to a drug used for treating cervical spondylosis. The effective components of the drug are prepared by following crude drugs: black snake, degelatined deerhorn, stir-baked squama manitis, caulis millettiae, centipede, paeonide alba, chrokee rose fruit, drynaria, curare (raw or prepared), curare powder, libanus, myrrh, parasite scurrula, erythrinae, red ginseng and excrementum, and one or a plurality of epimedium, Chinese clematis root, incised notopterygium, angelica tuhov, lignum sappan, tuberculate speranskia herb, lycopodii, kudzuvine root or thomson kudzu, atractylodes macrocephala, prepared rhizome of rehmannia, pyritum, dipsaci, scorpio, ground beetle and lodestone. The preparation forms include oral preparation and external preparation. The invention composition can effectively treat cervical spondylosis, in particular to patients with nerve root and cervical types cervical spondylosis.

Description

A kind of medicine for the treatment of cervical spondylosis
Technical field
The present invention relates to a kind of medicine for the treatment of cervical spondylosis, belong to technical field of medicaments.
Technical background
Cervical spondylosis is the commonly encountered diseases and the frequently-occurring disease of middle-aged and elderly people.Statistics shows, nearly 25% people suffered from or just suffering from cervical spondylosis among the crowd of China about 50 years old, by 60 years old, suffered from this patient up to 50%.China has stepped into aged society, and old people's population proportion has reached 15%, counts more than 200,000,000 people.And the morbidity crowd of cervical spondylosis progressively rejuvenation in recent years.Youngster cervical spondylosis sickness rate about 30 years old has the trend that rises year by year, as driver, reporter, clerk, white collar worker, typist, personnel's sickness rate of particularly being engaged in computer for a long time is higher and mostly relatively younger, even just the middle school student of teens also cervical spondylosis can occur.The but never effective especially Therapeutic Method of the treatment of right cervical spondylosis.Mainly contain non-operative treatment and operative treatment two classes at present.Non-operative treatment comprises: the braking of neck circumference neck, traction, physical therapy, massage and massage, oral drugs and external used medicine etc.Operative treatment comprises: anterior cervical operation, posterior approach, the road combined operation in front and back, Wicresoft's cervical operation and artificial cervical intercalated disc replacement operation etc.Right operative treatment can not be taked easily, because the neck structure complexity is the position that numerous nerves, blood vessel, cental system pass through, the vertebral artery as the supply cerebral blood vessel passes through from the cervical vertebra both sides.The cervical vertebra position is the initial position of digestive tract and respiratory tract, and the spinal cord of cervical vertebra inside is the outpost of the tax office of brain and whole body nerve connections.Spinal cord is the passage of sensation beyond the transmission head.The operation sequela is easily sent out in operation again, and is only very serious in pressure symptom so cervical spondylosis adopts non-operative treatment mostly, just considers to adopt operative treatment when all dangerous at any time.Occur using the mode of Western medicine injection to treat in recent years, but generally be relief of symptoms, can't reach satisfied curative effect.In non-operative treatment, the braking of neck circumference neck, traction, physical therapy, massage and massage etc. are cured the symptoms, not the disease, and Western medicine does not still have comparatively ideal Therapeutic Method, so domestic in the last few years a large amount of this disease of utilization traditional Chinese medical herbal treatment.
In existing data, can be used for the Chinese medicine or the existing many reports of its compositions of treatment of cervical spondylopathy.For example, application number is a Chinese medicine of having reported the treatment cervical spondylosis of forming with many ingredients such as Radix Puerariae, Radix Clematidis, Caulis Spatholobi, Radix Salviae Miltiorrhizae, Rhizoma Et Radix Notopterygii, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Colla cornus cervi, Rhizoma Chuanxiong, Rhizoma Drynariae in 200410018729.8 the Chinese patent open source literature; But in the document report medicine of the present invention has been carried out pulverization process, the bad flavor of smelling of many medicines can't be covered, and dosage form is single, and bioavailability is low, patient's poor compliance.Application number is to have reported a kind of treatment hyperosteogeny of being made up of medicines such as Radix Rehmanniae Preparata, Radix Morindae Officinalis, Colla cornus cervi, Herba Epimedii, Radix Dipsaci, the Radix Paeoniae Alba, Caulis Spatholobi, Radix Angelicae Sinensis, Semen Persicae, Radix Achyranthis Bidentatae, Radix Rubiae, Olibanum, Myrrha, Herba Ephedrae, Ramulus Cinnamomi, Radix Clematidis, Radix Gentianae Macrophyllae, Radix Glycyrrhizaes and the medicine of complication thereof in 200410073507.6 the Chinese patent open source literature, this medicine is in conjunction with the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of the traditional Chinese medical science, pay attention to principle-method-recipe-medicines, but this medicine method for making operability is relatively poor, it is bigger to implement the industrialization difficulty, can't the better service masses.In addition, be respectively 0115047.5 at application number, 02135882.6,03139198.2, among the 93110274.X, 96101071.1,99112137.6,200410010244.4,200410022888.5,200510017479.0, many Chinese patent open source literatures such as 01127477.8, also all reported the pharmaceutical composition that can be used for treating cervical spondylosis of different composition forms respectively.But exist curative effect not obvious mostly, the defectives such as misery of can not effecting a radical cure and take medicine.Therefore, research and develop a kind of determined curative effect, expense is low, no pain, and technological operation is strong, and mouthfeel is good, and the newtype drug that is more suitable for popular medication seems particularly urgent.
Summary of the invention
Based on above-mentioned situation, in order to treat cervical spondylosis effectively, the invention provides that a kind of good effect, short treating period, expense are low, no pain, preparation new pharmaceutical composition easy, easy to carry, this pharmaceutical composition has liver and kidney tonifying, bone and muscle strengthening, expelling wind and dampness, the function of promoting blood circulation to remove obstruction in the collateral.
Another object of the present invention provides manufacturing method for above mentioned medicine.
The object of the invention also is to provide the application of said medicine in preparation treatment cervical spondylosis medicine.
The present invention is achieved by the following technical solutions:
A kind of medicine for the treatment of cervical spondylosis, the crude drug of making this effective ingredient contains: Zaocys, Cornu Cervi Degelatinatum, stir-baked SQUAMA MANITIS, Caulis Spatholobi, Scolopendra, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Rhizoma Drynariae, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum, Olibanum, Myrrha, Herba Taxilli, Cortex erythrinae, Radix Ginseng Rubra, Oletum Trogopterori.
The above-mentioned raw materials medicine by weight, its proportioning can be Zaocys 10-50 part, stir-baked SQUAMA MANITIS 5-25 part, Cornu Cervi Degelatinatum 5-25 part, Radix Paeoniae Alba 20-100 part, Fructus Rosae Laevigatae 5-15 part, Scolopendra 3-17 part, Caulis Spatholobi 6-34 part, Rhizoma Drynariae 5-25 part, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum 2-8 part, Olibanum 5-15 part, Myrrha 5-15 part, Herba Taxilli 12-28 part, Cortex erythrinae 5-25 part, Radix Ginseng Rubra 5-15 part, Oletum Trogopterori 5-15 part; Preferred weight portion proportioning is: Zaocys 20-40 part, Cornu Cervi Degelatinatum 10-20 part, stir-baked SQUAMA MANITIS 10-20 part, Radix Paeoniae Alba 50-70 part, Fructus Rosae Laevigatae 8-12 part, Scolopendra 5-15 part, Caulis Spatholobi 15-25 part, Rhizoma Drynariae 10-20 part, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum 3-7 part, Olibanum 8-12 part, Myrrha 8-12 part, Herba Taxilli 15-25 part, Cortex erythrinae 10-20 part, Radix Ginseng Rubra 8-12 part, Oletum Trogopterori 8-12 part; Its optimum weight part proportioning is: 30 parts of Zaocyss, 15 parts of stir-baked SQUAMA MANITISs, 15 parts of Cornu Cervi Degelatinatums, 60 parts of the Radix Paeoniae Albas, 10 parts of Fructus Rosae Laevigatae, 10 parts of Scolopendras, 20 parts of Caulis Spatholobis, 15 parts of Rhizoma Drynariae, Semen Strychni (giving birth to or system) or 5 parts of Semen Strychni Pulveratums, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of Herba Taxillis, 15 parts of Cortex erythrinaes, 10 parts of Radix Ginseng Rubra, 10 parts of Oletum Trogopteroris.
As raw materials of effective components in the medicine of the present invention, except that mentioned component, can also comprise in Herba Epimedii, Radix Clematidis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae or Pachyrhizua angulatus, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Rhizoma Cibotii, Pyritum, Radix Dipsaci, Scorpio, Eupolyphaga Seu Steleophaga, the Magnetitum one or more.
The above-mentioned raw materials medicine of making this effective ingredient by weight, its weight portion proportioning can be Herba Epimedii 5-15 part, Radix Clematidis 5-25 part, Rhizoma Et Radix Notopterygii 5-15 part, Radix Angelicae Pubescentis 5-15 part, Lignum Sappan 12-28 part, Herba speranskiae tuberculatae 12-28 part, Herba Lycopodii 5-25 part, Radix Puerariae or Pachyrhizua angulatus 12-28 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Rehmanniae Preparata 12-28 part, Pyritum 5-15 part, Radix Dipsaci 5-15 part, Rhizoma Cibotii 12-28 part, Scorpio 2-8 part, Eupolyphaga Seu Steleophaga 5-15 part, Magnetitum 10-90 part; Preferred weight portion proportioning is: Herba Epimedii 8-12 part, Radix Clematidis 10-20 part, Rhizoma Et Radix Notopterygii 8-12 part, Radix Angelicae Pubescentis 8-12 part, Lignum Sappan 15-25 part, Herba speranskiae tuberculatae 15-25 part, Herba Lycopodii 10-20 part, Radix Puerariae 15-25 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Rehmanniae Preparata 15-25 part, Pyritum 8-12 part, Radix Dipsaci 8-12 part, Rhizoma Cibotii 15-25 part, Scorpio 3-7 part, Eupolyphaga Seu Steleophaga 8-12 part, Magnetitum 35-65 part; Its optimum weight part proportioning is: 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 20 parts of Lignum Sappans, 20 parts of Herba speranskiae tuberculataes, 15 parts of Herba Lycopodiis, 20 parts of Radix Puerariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Radix Rehmanniae Preparata, 10 parts of Pyritums, 10 parts of Radix Dipsacis, 20 parts of Rhizoma Cibotii, 5 parts of Scorpios, 10 parts of Eupolyphaga Seu Steleophagas, 50 parts of Magnetitums.
Compound mode is exemplified below:
(1) Zaocys 10-50 part, stir-baked SQUAMA MANITIS 5-25 part, Cornu Cervi Degelatinatum 5-25 part, Radix Paeoniae Alba 20-100 part, Scolopendra 3-17 part, Caulis Spatholobi 6-34 part, Rhizoma Drynariae 5-25 part, Fructus Rosae Laevigatae 5-15 part, Semen Strychni (system) 2-8 part, Olibanum 5-15 part, Myrrha 5-15 part, Herba Taxilli 12-28 part, Cortex erythrinae 5-25 part, Radix Ginseng Rubra 5-15 part, Oletum Trogopterori 5-15 part.
(2) Zaocys 15-45 part, stir-baked SQUAMA MANITIS 8-22 part, Cornu Cervi Degelatinatum 8-22 part, Radix Paeoniae Alba 30-90 part, Scolopendra 5-15 part, Caulis Spatholobi 10-30 part, Rhizoma Drynariae 8-22 part, Fructus Rosae Laevigatae 6-14 part, Semen Strychni Pulveratum 3-7 part, Olibanum 8-12 part, Myrrha 8-12 part, Herba Taxilli 15-25 part, Cortex erythrinae 8-22 part, Radix Ginseng Rubra 8-12 part, Oletum Trogopterori 8-12 part, Rhizoma Cibotii 12-28 part, Herba Epimedii 5-15 part, Radix Dipsaci 5-15 part, Radix Rehmanniae Preparata 12-28 part, Magnetitum 10-90 part.
(3) Zaocys 20-40 part, stir-baked SQUAMA MANITIS 10-20 part, Cornu Cervi Degelatinatum 10-20 part, Radix Paeoniae Alba 40-80 part, Scolopendra 6-14 part, Caulis Spatholobi 12-28 part, Rhizoma Drynariae 10-20 part, Fructus Rosae Laevigatae 8-12 part, Semen Strychni 4-6 part, Olibanum 8-12 part, Myrrha 8-12 part, Herba Taxilli 16-24 part, Cortex erythrinae 10-20 part, Radix Ginseng Rubra 8-12 part, Oletum Trogopterori 8-12 part, Radix Clematidis 5-25 part, Rhizoma Et Radix Notopterygii 5-15 part, Radix Angelicae Pubescentis 5-15 part, Herba speranskiae tuberculatae 12-28 part, Herba Lycopodii 5-25 part, Radix Puerariae 12-28 part, Scorpio 2-8 part.
(4) Zaocys 25-35 part, stir-baked SQUAMA MANITIS 12-18 part, Cornu Cervi Degelatinatum 12-18 part, Radix Paeoniae Alba 50-70 part, Scolopendra 8-12 part, Caulis Spatholobi 15-25 part, Rhizoma Drynariae 12-18 part, Fructus Rosae Laevigatae 8-12 part, Semen Strychni (system) 2-8 part, Olibanum 8-12 part, Myrrha 8-12 part, Herba Taxilli 15-25 part, Cortex erythrinae 10-20 part, Radix Ginseng Rubra 8-12 part, Oletum Trogopterori 8-12 part, Pyritum 5-15 part, Lignum Sappan 12-28 part, Eupolyphaga Seu Steleophaga 5-15 part.
(5) Zaocys 10-50 part, stir-baked SQUAMA MANITIS 5-25 part, Cornu Cervi Degelatinatum 5-25 part, Radix Paeoniae Alba 20-100 part, Scolopendra 3-17 part, Caulis Spatholobi 6-34 part, Rhizoma Drynariae 5-25 part, Fructus Rosae Laevigatae 5-15 part, Semen Strychni 2-8 part, Olibanum 5-15 part, Myrrha 5-15 part, Herba Taxilli 12-28 part, Cortex erythrinae 5-25 part, Radix Ginseng Rubra 5-15 part, Oletum Trogopterori 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part.
(6) Zaocys is 30 parts, 15 parts of stir-baked SQUAMA MANITISs, 15 parts of Cornu Cervi Degelatinatums, 60 parts of the Radix Paeoniae Albas, 10 parts of Scolopendras, 20 parts of Caulis Spatholobis, 15 parts of Rhizoma Drynariae, 10 parts of Fructus Rosae Laevigatae, 5 parts of Semen Strychni Pulveratums, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of Herba Taxillis, 15 parts of Cortex erythrinaes, 10 parts of Radix Ginseng Rubra, 10 parts of Oletum Trogopteroris, 20 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 20 parts of Lignum Sappans, 20 parts of Herba speranskiae tuberculataes, 15 parts of Herba Lycopodiis, 20 parts of Radix Puerariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Radix Rehmanniae Preparata, 50 parts of Magnetitums, 10 parts of Pyritums, 10 parts of Eupolyphaga Seu Steleophagas, 10 parts of Radix Dipsacis, 5 parts of Scorpios.
The combinations thereof mode is only enumerated compound mode of the present invention, but the combination that this should be interpreted as the above-mentioned theme of the present invention only only limits to the combination shown in above-mentioned.
A kind of preparation method for the treatment of the medicine of cervical spondylosis comprises each active drug composition is cleaned respectively, pulverizes, and mixes.
Preparation method can also comprise: with each active drug composition, add water or Different concentrations of alcohol or enzyme bionic extraction respectively, the extracting solution concentrate drying gets extract, or further adopt alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.
Described adjuvant can be different according to different preparations, as add diluent commonly used, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc. in solid preparations such as tablet, capsule, granule; In liquid preparation forms such as syrup, oral liquid, add surfactant commonly used, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; In external preparation forms such as gel, ointment, add medicinal oleaginous base commonly used, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.
A kind of application of medicine in disease medicaments such as preparation treatment spondylotic radiculopathy, myeloid form, vertebral artery type, neck type, sympathetic type and other myelopathys for the treatment of cervical spondylosis.
According to the theory of Chinese medicine, the pathogenesis multi-source of cervical spondylosis is in caused by liver and kidney deficiency, and the deficiency of vital energy blood vessels of holding concurrently are not smooth, so that neck is strong, and blood is sought not enough, on this basis, if continue the strain or the damp that is affected by the cold, causes easily that promptly the sclerotin degeneration forms this disease.So with the deficiency of vital energy, deficiency of the liver and kindey, the resistance of the anemofrigid-damp arthralgia stasis of blood is main pathogenesis.When with liver and kidney tonifying, bone and muscle strengthening, expelling wind and dampness, promoting blood circulation to remove obstruction in the collateral are the rule of treatment.
In the present invention basis side, Cornu Cervi Degelatinatum, Rhizoma Drynariae, Fructus Rosae Laevigatae, Herba Taxilli liver and kidney tonifying, bone and muscle strengthening; Stir-baked SQUAMA MANITIS, Zaocys, Scolopendra, Cortex erythrinae, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum expelling wind and dampness; Caulis Spatholobi, the Radix Paeoniae Alba, Olibanum, Myrrha, Oletum Trogopterori promoting blood circulation to remove obstruction in the collateral; The Radix Ginseng Rubra strongly invigorating primordial QI.
In forming effective ingredient of the present invention, Cornu Cervi Degelatinatum has the effect of kidney invigorating and YANG supporting, the hard bone of life essence-filling, marrow-benefitting; Modern pharmacology studies show that Cornu Cervi Degelatinatum can suppress osteoclast activity, stimulating osteoblast propagation, and bone matrix forms and increases, and the contained calcareous ossific process that helps promotes union of fracture; The kidney invigorating of Fructus Rosae Laevigatae controlling nocturnal emission with astringent drugs, Rhizoma Drynariae the kidney invigorating bone strengthening continues and hinders pain relieving, has the promotion bone resorption, and extract shows that significantly analgesia waits effect; The invigorating the liver and kidney of Herba Taxilli tool removes rheumatism, and the function of bone and muscle strengthening has good efficacy to ankylosing spondylitis; Play liver and kidney tonifying altogether, the function of bone and muscle strengthening is to control the disease of its deficiency in origin; For hepatic and renal YIN deficiency severe patient, one or more in compatibility Radix Rehmanniae Preparata, Herba Epimedii, Rhizoma Cibotii, Radix Dipsaci, the Magnetitum; The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature, the tool nourishing YIN and supplementing blood, beneficial essence is filled out the function of marrow; The Herba Epimedii invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling; The Rhizoma Cibotii invigorating the liver and kidney, strong waist knee joint, wind-damp dispelling, the Radix Dipsaci invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered; The Magnetitum suppressing the hyperactive liver and subsiding YANG, tranquillizing the mind by relieving convulsion; Nurse one's health the not good patient of Liver and kidney better; The Zaocys wind-damp dispelling, the meridian dredging; Stir-baked SQUAMA MANITIS is kind scurries, and specially can manage it and loose, and the meridian dredging reaches disease institute, is the key medicine of blood circulation promoting and blood stasis dispelling, the network that stimulates the menstrual flow; Scolopendra relieving spasm by subduing liver-wind, detoxicating and resolving stagnation of pathogens, removing obstruction in the collateral to relieve pain; The Cortex erythrinae wind-damp dispelling, collateral dredging, pain relieving; The Semen Strychni removing obstruction in the collateral to relieve pain, dispersing swelling and dissipating binds; Above-mentioned all medicines share, and bring into play expelling wind and removing dampness jointly, and removing obstruction in the collateral to relieve pain ends imitates.Be main disorder for the rheumatism retardance, add in Radix Clematidis, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Scorpio, Rhizoma Et Radix Notopterygii, the Radix Angelicae Pubescentis one or more; Radix Clematidis acrid in the mouth warm in nature is walked to scurry and is not stayed heresy, and dry and invigorate blood circulation, be main effect with its " wind-damp dispelling, the meridian dredging "; The Herba speranskiae tuberculatae expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, removing obstruction in the collateral to relieve pain; The Herba Lycopodii expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral; Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis compatibility use expelling wind and removing dampness, numbness relieving and pain relieving; The Radix Puerariae removing obstruction in the collateral to relieve pain; Scorpio and Scolopendra compatibility, collaborative mutually, the performance better therapeutic; Caulis Spatholobi is invigorated blood circulation, collateral dredging; Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, slow middle pain relieving it is reported that effective ingredient white peony root's total glycoside capsule for treating ankylosing spondylitis clinical efficacy is remarkable; Oletum Trogopterori is invigorated blood circulation, blood stasis dispelling, pain relieving.For the blood stasis patient, one or more in some promoting blood circulation, removing blood stasis and relieving pain medicines of compatibility such as Pyritum, Eupolyphaga Seu Steleophaga, Olibanum, Myrrha, the Lignum Sappan etc.The Pyritum reunion of bone, eliminating stasis to stop pain, Eupolyphaga Seu Steleophaga removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones; Olibanum, Myrrha, Lignum Sappan etc. are used with compatibilities such as Oletum Trogopterori, the Radix Paeoniae Alba, Caulis Spatholobis, bring into play blood circulation promoting and blood stasis dispelling jointly, the effect of pain relieving; The Radix Ginseng Rubra strongly invigorating primordial QI, nourishing qi to stop; For insufficiency of the spleen patient such as grade, add the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, the two share, and treats the deficiency syndrome of all gas altogether.Make a general survey of full side, all medicines are instrumental ensembled, and the prosperous blood of gas fills, and muscles and bones must be good for, and passages through which vital energy circulates is unobstructed, and arthralgia pain must remove, and plays liver and kidney tonifying altogether, bone and muscle strengthening, expelling wind and dampness, the effect of promoting blood circulation to remove obstruction in the collateral.So the basic cause of disease disease of foundation has been established and treated the square substantially of this disease: promptly prescription is the basis side of Zaocys, Cornu Cervi Degelatinatum, stir-baked SQUAMA MANITIS, Caulis Spatholobi, Scolopendra, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Rhizoma Drynariae, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum, Olibanum, Myrrha, Herba Taxilli, Cortex erythrinae, Radix Ginseng Rubra, Oletum Trogopterori.In the present invention, pay attention to the organic conception and the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs feature of the traditional Chinese medical science again, pay attention to principle-method-recipe-medicines,, change, increase its related drugs according to differences such as the disease of curing the disease, positions.
The present invention is foundation with the theory of Chinese medical science, adopts the above-mentioned active drug composition prescription that cooperatively interacts, and is when research and having compiled successive dynasties tradition name side speciality, combines the achievement and the clinical proved recipe of modern scientific research again.Various result of the tests show, it is definite effect aspect multiple cervical spondylosis illness such as spondylotic radiculopathy, neck type, vertebral artery type, sympathetic type, its alloytype, show that its active drug component cooperates in order, can be used for treatment, the especially spondylotic radiculopathy of cervical spondylosis, cervical spondylopathy patient's treatment effectively.
Experiment shows that Zaocys water decoction or alcohol extract have remarkable analgesic activity to mice; Squama Manis mainly contains effective ingredient such as aminoacid, ring dipeptides, volatile oil, alkaloid and trace element; Cornu Cervi Degelatinatum mainly contains compositions such as inorganic elements and colloid; Compositions such as glycoside composition, paeonol, benzoic acid, cupreol, volatile oil, fatty oil, resin, sugar, starch, protein, triterpenes such as Radix Paeoniae Alba main component such as peoniflorin; Compositions such as the main fatty acids of Scolopendra, protein, aminoacid, enzyme and cholesterol; Caulis Spatholobi mainly contains formononetin, ononin, prunusetin., protocatechuic acid, daucosterol and microelements of calcium, zinc, copper etc.; Fructus Rosae Laevigatae mainly contains compositions such as saponins, oleanolic acid, glucose, daucosterol; Semen Strychni mainly contains alkaloids such as strychnine, strychnine; Oletum Trogopterori mainly contains flavones ingredient; Rhizoma Drynariae, Herba Taxilli, the main effective ingredient of Herba Epimedii are flavones ingredient; Compositions such as Olibanum, Myrrha are mainly resinous, volatile oil, natural gum; Cortex erythrinae mainly contains alkaloid and saponin component etc.; Radix Ginseng Rubra mainly contains saponin component etc.; Rhizoma Cibotii mainly contains compositions such as terpenoid, vanillin, syringic aldehyde, hydroxy benzaldehyde, acetovanilone; Compositions such as the main protoanemonin of Radix Clematidis, Anemonin, clematoside and multiple oleanoside; Rhizoma Et Radix Notopterygii mainly contains volatile oil compositions such as australene, nopinene, limonene, carbohydrate contents such as rhamnose, fructose, glucose, sucrose, aminoacid, organic acid, compositions such as cupreol, different RADIX PEUCEDANI aglycon; Radix Angelicae Pubescentis contains compositions such as volatile oil, Coumarins; Lignum Sappan mainly contains fatty acid, brazilin, volatile oil composition; Herba speranskiae tuberculatae mainly contains phenols component; Herba Lycopodii mainly contains compositions such as alkaloids, organic acid, sterols, physcione; Radix Puerariae mainly contains compositions such as bean aglycon, daiazi, puerarin; The Rhizoma Atractylodis Macrocephalae mainly contains volatile oil, sesquiterpenoids, contains compositions such as oxygen dicoumarol class; The Radix Rehmanniae Preparata chemical constituent is based on glycoside; Pyritum mainly contains ferrous disulfide FeS 2, still contain elements such as a spot of aluminum, calcium, titanium, silicon; The Magnetitum main component is a ferroso-ferric oxide; Eupolyphaga Seu Steleophaga mainly contains volatile oil and amino acids composition; Radix Dipsaci mainly contains erythricine (getianine), triterpenoid saponin constituents; The Scorpio main chemical compositions is a scorpion venom; Mentioned component has better water solubility or pure dissolubility mostly; In view of macromolecular substances such as animal proteinoid, mucopolysaccharide are subjected to effects such as digestive enzyme, acid, alkali behind gastrointestinal tract, can or be hydrolyzed to micromolecular peptide, oligosaccharide and other small-molecule substances by enzymolysis, be absorbed into blood and bring into play drug effect.So to above-mentioned animal drugs be used as medicine except that direct pulverizing carry with the common water of other medicines or alcohol extraction, also can adopt digestion process in the enzyme bionic extraction method analogue body.
Therefore, when stating medicine in the use, both can adopt with the medicine that is equivalent to described weight proportion is that raw material can clean the above-mentioned raw materials medicine respectively, dry, pulverize, mix the granule or the powder that obtain meeting preparation requirement granularity and directly take.Certainly, also can adopt with the medicine that is equivalent to described weight proportion relation is that raw material adds pharmaceutic adjuvant through suitably handling the back, be made into various preparations as required, be mainly oral formulations and external preparation:, also can make the oral drugs of liquid preparation forms such as syrup, oral liquid as making the oral drugs of solid preparation forms such as tablet commonly used, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet, effervescent tablet, capsule, soft capsule, microcapsule, granule, pill, powder, drop pill, slow releasing preparation, controlled release preparation; Can also make the external used medicine of external preparation forms such as unguentum, gel, ointment, cataplasma, emplastrum, liniment, lotion, liniment.Be prepared into by the above-mentioned raw materials medicine in the process of preparation, the above-mentioned raw materials medicine can adopt following method to handle: add water or Different concentrations of alcohol or enzyme bionic extraction respectively, the extracting solution concentrate drying gets crude extract; Or adopt further that alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; Adoptable concrete operations and/or using method when above-mentioned effective medicinal ingredient is extracted, both can be that ingredient with described each proportional quantities is a raw material, extract decomposite mode behind its effective medicinal ingredient respectively, also can adopt each medicine material by said proportional quantities to mix after the mode of co-extracted again.Adopt different extraction means, equipment and actual conditionses such as required desirable or best extraction temperature, solvent load, extraction time, extraction time when extracting, then can be according to practical situation by testing screened and finding.With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.Therefore, except that effective ingredient, can also contain pharmaceutically acceptable adjuvant in this pharmaceutical composition.
Adjuvant described here can be different according to different preparations, as diluent commonly used in solid preparations such as tablet, capsule, granule, disintegrating agent, excipient, binding agent, lubricant, surfactant, filler etc.; The surfactant of in liquid preparation forms such as syrup, oral liquid, using always, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer etc.; The medicinal oleaginous base of in external preparation forms such as gel, ointment, using always, aqueous matrix, antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant etc.Its adjuvant commonly used such as starch, lactose, dextrin, Icing Sugar, microcrystalline Cellulose, mannitol, xylitol, Polyethylene Glycol, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, modified starch, sorbitol, polyvidon, Heavy Magnesium Carbonate, sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethyl cellulose, carboxymethylstach sodium, hydroxypropyl cellulose, 30 POVIDONE K 30 BP/USP 30, kaolin, pregelatinized Starch, magnesium stearate, Pulvis Talci, micropowder silica gel, stevioside, betanin, aspartame, glycyrrhizin, saccharin sodium, citric acid, sodium bicarbonate, sodium carbonate, carrageenan, agar, gelatin, sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, locust bean gum, POLY-karaya, stearic acid, glyceryl monostearate, polyacrylamide, cross linked sodium polyacrylate, polyvinyl alcohol, carbomer, sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, thimerosal, dimethyl sulfoxide, azone, triethanolamine, sodium hydroxide, glycerol, propylene glycol, BHT, BHA, sodium lauryl sulphate, Tweens, spans etc.
For preparation above-mentioned, 15 flavors of basis side and 31 preparation methoies of distinguishing the flavor of of greatest combined side are exemplified below:
Basis side's 15 flavor active drug compositions are: Zaocys, Cornu Cervi Degelatinatum, stir-baked SQUAMA MANITIS, Caulis Spatholobi, Scolopendra, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Rhizoma Drynariae, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum, Olibanum, Myrrha, Herba Taxilli, Cortex erythrinae, Radix Ginseng Rubra, Oletum Trogopterori.
Tablet adopts following method preparation in the solid orally ingestible:
Above-mentioned 15 flavors, Scolopendra is ground into fine powder, and is standby; Olibanum, Myrrha add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues and all the other Cornu Cervi Degelatinatums, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae are ground into coarse powder, add 4～15 times of water gagings at every turn and decoct 1～8 time, and each 0.5～5.0 hour, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge, and are condensed into thick paste; Caulis Spatholobi, Oletum Trogopterori, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra add 3～10 times of amount 30～95% ethanol, heating and refluxing extraction 1～10 time, each 0.5～8.0 hour, merge extractive liquid, at every turn, filter, filtrate recycling ethanol also is condensed into thick paste, with above-mentioned thick paste and Scolopendra fine powder, Semen Strychni Pulveratum mix homogeneously, drying is ground into fine powder, adds right amount of auxiliary materials, mixing is granulated drying, above-mentioned volatile oil is added dissolve with ethanol, spray into, sealing, tabletting, coating or coating not promptly get tablet.
Oral liquid adopts following method preparation in the liquid oral medicine:
Above-mentioned 15 flavors are got Semen Strychni (processed), are ground into fine powder, and are standby; Get Scolopendra, add 10～30 times of simulated gastric fluids, airtight, add 1.5%～4.5% pepsin after 20～60 minutes in 30～45 ℃ of water bath with thermostatic control effects, act on after 2～5 hours, place 85 ℃ of water bath with thermostatic control effects after 5～35 minutes enzymolysis solution, after being cooled to room temperature, centrifugal, get supernatant, standby; Olibanum, Myrrha add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5～10: 50～100,30～70 ℃ stirring 0.5～2.0 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (30～60 ℃) drying is ground into fine powder; Medicinal residues and all the other Cornu Cervi Degelatinatums, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae are ground into coarse powder, and add 4～15 times of water gagings at every turn and decoct 1～8 time, each 0.5～5.0h, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 3～10 times of amount 30～95% ethanol, heating and refluxing extraction 1～10 time, each 0.5～8.0 hour at every turn, merge extractive liquid, filters, and filtrate recycling ethanol also suitably concentrates, merge with above-mentioned concentrated solution and supernatant, add Semen Strychni (processed) powder, stir, add an amount of flavoring agent, antiseptic, suspending agent, mix, add the water standardize solution, packing promptly gets oral liquid.
The preparation of simulated gastric fluid: get hydrochloric acid 9mL, adding distil water is diluted to 1000ml, promptly.
Gel is preparation like this in the external preparation:
Above-mentioned 15 flavors, Scolopendra, Semen Strychni Pulveratum are broken into fine powder, and be standby; Olibanum, Myrrha add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5～10: 50～100,30～70 ℃ stirring 0.5～2.0 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (30～60 ℃) drying is ground into fine powder; Medicinal residues and all the other Cornu Cervi Degelatinatums, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae add 4～15 times of water gagings at every turn and decoct 1～8 time, each 0.5～5.0h, and collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 3～10 times of amount 30～95% ethanol, heating and refluxing extraction 1～10 time, each 0.5～8.0 hour at every turn, merge extractive liquid, filters, and filtrate recycling ethanol also suitably concentrates, merge with above-mentioned concentrated solution, filter, filter, filtrate adds gel-type vehicle, wetting agent, antiseptic, stirs to make dissolving, places, make abundant swelling, add Semen Strychni Pulveratum, Scolopendra fine powder and add solvent and transfer to full dose, stir, make gel, promptly get gel.
The most generous 31 flavor active drug compositions are: Zaocys, Cornu Cervi Degelatinatum, stir-baked SQUAMA MANITIS, Caulis Spatholobi, Scolopendra, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Rhizoma Drynariae, Semen Strychni (giving birth to or system) or Semen Strychni Pulveratum, Olibanum, Myrrha, Herba Taxilli, Cortex erythrinae, Radix Ginseng Rubra, Oletum Trogopterori, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci, Scorpio, Eupolyphaga Seu Steleophaga, Magnetitum.
Granule is preparation like this in the solid orally ingestible:
Above-mentioned 31 flavors are got Scolopendra, Scorpio is ground into fine powder, and is standby; Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5～10: 50～100,30～70 ℃ stirring 0.5～2.0 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (30～60 ℃) drying is ground into fine powder; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Magnetitum, add 4～15 times of water gagings decocts 1～8 time at every turn, each 0.5～5.0h, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are condensed into thick paste; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 3～10 times of amount 30～95% ethanol, heating and refluxing extraction 1～10 time, each 0.5～8.0 hour at every turn, merge extractive liquid, filters, and filtrate recycling ethanol also is condensed into thick paste, merge mixing, drying with above-mentioned thick paste, Scolopendra, Scorpio, Semen Strychni Pulveratum, volatile oil inclusion complex fine powder, be ground into fine powder, add right amount of auxiliary materials, mixing, granulate, drying is made granule, packing promptly gets granule.
Syrup is preparation like this in the liquid oral medicine:
Above-mentioned 31 flavors, Scolopendra, Scorpio, Semen Strychni Pulveratum are broken into fine powder, and be standby; Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 5 flavors add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5～10: 50～100,30～70 ℃ stirring 0.5～2.0 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (30～60 ℃) drying is ground into fine powder; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Magnetitum 18 flavors add 4～15 times of water gagings at every turn and decoct 1～8 time, each 0.5～5.0h, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Oletum Trogopterori, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra 5 flavors add 3～10 times of amount 30～95% ethanol, heating and refluxing extraction 1～10 time, each 0.5～8.0 hour at every turn, merge extractive liquid, filters, and filtrate recycling ethanol also suitably concentrates, merge with above-mentioned concentrated solution, filter, add Scolopendra fine powder, Scorpio fine powder, Semen Strychni fine powder, stir, add an amount of flavoring agent, antiseptic, suspending agent, mix, add the water standardize solution, packing, promptly.
Gel is preparation like this in the external preparation:
Above-mentioned 31 flavors, Semen Strychni (processed) is ground into fine powder; Scolopendra adds 10～30 times of simulated gastric fluids, and is airtight, adds 1.5%～4.5% pepsin after 20～60 minutes in 30～45 ℃ of water bath with thermostatic control effects, act on after 2～5 hours, place 85 ℃ of water bath with thermostatic control effects after 5～35 minutes enzymolysis solution, be cooled to room temperature after, centrifugal, get supernatant, standby; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, Scorpio carry out the enzyme bionic extraction with method, respectively get supernatant, and be standby; Above-mentioned supernatant is merged, standby; Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 5 flavors add 5～15 times of amounts of water after mixing, and soak 0～8 hour, and steam distillation 4～12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5～10: 50～100,30～70 ℃ stirring 0.5～2.0 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (30～60 ℃) drying is ground into fine powder; The medicinal residues and the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Magnetitum 15 flavors add 4～15 times of water gagings at every turn and decoct 1～8 time, each 0.5～5.0 hour, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Oletum Trogopterori, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra 5 flavors add 3～10 times of amount 30～95% ethanol at every turn, heating and refluxing extraction 1～10 time, each 0.5～5.0 hour, merge extractive liquid,, filter, filtrate recycling ethanol also suitably concentrates, and merges with above-mentioned concentrated solution and supernatant, filter, filter, filtrate adds gel-type vehicle, wetting agent, antiseptic, stirs and makes dissolving, place, make abundant swelling, add Semen Strychni Pulveratum, volatile oil inclusion complex fine powder and add solvent and transfer to full dose, stir, make gel, promptly get gel.
For the preparation method of the square medicine between 15～31 flavors, can carry out with reference to above-mentioned technology.
Above-mentioned preparation method is only enumerated the present invention's method of obtaining through refining, but this should be interpreted as that preparation method of the present invention only only limits to above-mentioned cited method.
Drug main of the present invention will be used for the treatment of the cervical spondylosis of various typings such as spondylotic radiculopathy, myeloid form, vertebral artery type, neck type, sympathetic type and alloytype thereof.
According to foregoing,,, obviously can also make modification, replacement and the change of other various ways according to the ordinary skill knowledge and the customary means of this area not breaking away under the basic fundamental thought prerequisite of the present invention.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Concrete embodiment
Embodiment 1:
In weight proportion: 30 parts of Zaocyss, 15 parts of Cornu Cervi Degelatinatums, 15 parts of stir-baked SQUAMA MANITISs, 20 parts of Caulis Spatholobis, 10 parts of Scolopendras, 60 parts of the Radix Paeoniae Albas, 5 parts of Semen Strychni Pulveratums, 10 parts of Olibanums, 10 parts of Myrrhas, 15 parts of Rhizoma Drynariae, 20 parts of Herba Taxillis, 15 parts of Cortex erythrinaes, 10 parts of Radix Ginseng Rubra, 10 parts of Fructus Rosae Laevigatae, 10 parts of Oletum Trogopteroris.
Above-mentioned 15 flavors, Scolopendra is ground into fine powder, and is standby; Olibanum, Myrrha add 10 times of amounts of water after mixing, and steam distillation 10 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae 6 flavors are ground into coarse powder, adding 12,10,10 times of water gagings respectively decocts 3 times, 2 hours for the first time, second and third time difference 1 hour, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and being condensed into relative density is the thick paste of 1.05 (60 ℃); Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors add 70% alcohol heating reflux and extract 3 times, alcohol adding amount is respectively 8,6,6 times of amounts, extraction time was respectively 4 hours, 2 hours, 2 hours, merge extractive liquid, filtered, filtrate recycling ethanol also is condensed into the thick paste that relative density is 1.05 (60 ℃), with above-mentioned thick paste and Scolopendra fine powder, the Semen Strychni Pulveratum mix homogeneously, drying is ground into fine powder, it is an amount of to add dextrin and microcrystalline Cellulose, mixing is granulated drying, above-mentioned volatile oil is added dissolve with ethanol, spray into, seal 5 minutes, tabletting, the bag film-coat promptly gets tablet.
Embodiment 2:
In weight proportion: 15 parts of Zaocyss, 8 parts of stir-baked SQUAMA MANITISs, 8 parts of Cornu Cervi Degelatinatums, 30 parts of the Radix Paeoniae Albas, 5 parts of Scolopendras, 10 parts of Caulis Spatholobis, 8 parts of Rhizoma Drynariae, 6 parts of Fructus Rosae Laevigatae, 3 parts of Semen Strychni, 8 parts of Olibanums, 8 parts of Myrrhas, 15 parts of Herba Taxillis, 8 parts of Cortex erythrinaes, 8 parts of Radix Ginseng Rubra, 8 parts of Oletum Trogopteroris, 12 parts of Rhizoma Cibotii, 5 parts of Herba Epimedii, 5 parts of Radix Dipsacis, 12 parts in Radix Rehmanniae Preparata, 10 parts of Magnetitums
Above-mentioned 20 flavors are got Scolopendra, Semen Strychni Pulveratum is broken into fine powder, and is standby; Olibanum, Myrrha add 5 times of amounts of water after mixing, and soak 8 hours, and steam distillation 8 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 8: 80,35 ℃ were stirred 1.5 hours), cold preservation is spent the night, and filters, and inclusion complex low temperature (35 ℃) drying is ground into fine powder; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci 11 flavors add 10 times of water gagings at every turn and decoct 4 times, each 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the thick paste that relative density is 1.10 (55 ℃ of surveys); Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors add 6,4,4 times of amount 50% ethanol, heating and refluxing extraction 3 times, 3 hours for the first time respectively, second and third time 2 hours, merge extractive liquid, filters, and filtrate recycling ethanol is concentrated into the thick paste that relative density is 1.08 (60 ℃ of surveys); Merge with above-mentioned thick paste, Scolopendra, Semen Strychni fine powder, volatile oil inclusion complex fine powder, mix homogeneously, drying is ground into fine powder, and adding starch is an amount of, and mixing is granulated, and drying is made granule, and packing promptly gets granule.
Embodiment 3:
In weight proportion: 40 parts of Zaocyss, 20 parts of stir-baked SQUAMA MANITISs, 20 parts of Cornu Cervi Degelatinatums, 80 parts of the Radix Paeoniae Albas, 14 parts of Scolopendras, 28 parts of Caulis Spatholobis, 20 parts of Rhizoma Drynariae, 12 parts of Fructus Rosae Laevigatae, 6 parts of Semen Strychni (system), 12 parts of Olibanums, 12 parts of Myrrhas, 24 parts of Herba Taxillis, 20 parts of Cortex erythrinaes, 12 parts of Radix Ginseng Rubra, 12 parts of Oletum Trogopteroris, 25 parts of Radix Clematidis, 15 parts of Rhizoma Et Radix Notopterygiis, 15 parts of Radix Angelicae Pubescentiss, 28 parts of Herba speranskiae tuberculataes, 25 parts of Herba Lycopodiis, 28 parts of Radix Puerariaes, 8 parts of Scorpios
Above-mentioned 22 flavors, Scolopendra, Scorpio, Semen Strychni (processed) are ground into fine powder, and be standby; Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis add 15 times of water gagings after mixing, and steam distillation 10 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 5: 50,50 ℃ were stirred 2 hours), cold preservation is spent the night, and filters, and inclusion complex low temperature (40 ℃) drying is ground into fine powder; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Cortex erythrinae, Radix Clematidis, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae 10 flavors add 6,4,4 times of water gagings respectively and decoct 3 times, decocted 5 hours for the first time, second and third time decocted respectively 2 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are condensed into the thick paste that relative density is 1.12 (50 ℃); Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors add 5 times of amount 30% ethanol at every turn, reflux, extract, 4 times, each 3 hours, merge extractive liquid, filters, and filtrate recycling ethanol also is condensed into the thick paste that relative density is 1.02 (50 ℃), with above-mentioned thick paste, the Scolopendra fine powder, the Semen Strychni (processed) fine powder, volatile oil inclusion complex fine powder merges, mixing, drying is ground into fine powder, it is an amount of to add 12% crospolyvinylpyrrolidone and hyprolose-microcrystalline Cellulose (1: 1), mixing is granulated drying, add crospolyvinylpyrrolidone 6% and 0.5% magnesium stearate, mixing, tabletting promptly gets dispersible tablet.
Embodiment 4:
In weight proportion: 25 parts of Zaocyss, 12 parts of stir-baked SQUAMA MANITISs, 12 parts of Cornu Cervi Degelatinatums, 50 parts of the Radix Paeoniae Albas, 8 parts of Scolopendras, 15 parts of Caulis Spatholobis, 12 parts of Rhizoma Drynariae, 12 parts of Fructus Rosae Laevigatae, 4 parts of Semen Strychni (system), 8 parts of Olibanums, 8 parts of Myrrhas, 15 parts of Herba Taxillis, 10 parts of Cortex erythrinaes, 8 parts of Radix Ginseng Rubra, 8 parts of Oletum Trogopteroris, 15 parts of Pyritums, 28 parts of Lignum Sappans, 5 parts of Eupolyphaga Seu Steleophagas
Above-mentioned 18 flavors, Scolopendra, Semen Strychni (processed) are ground into fine powder, and be standby; Olibanum, Myrrha add 8 times of amounts of water after mixing, and soak 2 hours, and steam distillation 10 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 10: 100,40 ℃ were stirred 1 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (50 ℃) drying is ground into fine powder; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae, Pyritum, Lignum Sappan, Eupolyphaga Seu Steleophaga 9 flavors add 12,12,10 times of water gagings respectively and decoct 3 times, 2 hours for the first time, second and third time was respectively 1 hour, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 8,6,4 times of amount 40% ethanol, heating and refluxing extraction 3 times, each 2 hours respectively, merge extractive liquid, filters, and filtrate recycling ethanol also suitably concentrates, merge with above-mentioned concentrated solution, filter, add Scolopendra fine powder, Semen Strychni fine powder, stir, add an amount of saccharin sodium, flavoring orange essence, potassium sorbate, tween 80, mix, add the water standardize solution, packing promptly gets syrup.
Embodiment 5:
In weight proportion: 50 parts of Zaocyss, 25 parts of stir-baked SQUAMA MANITISs, 25 parts of Cornu Cervi Degelatinatums, 100 parts of the Radix Paeoniae Albas, 17 parts of Scolopendras, 34 parts of Caulis Spatholobis, 25 parts of Rhizoma Drynariae, 15 parts of Fructus Rosae Laevigatae, 8 parts of Semen Strychni (processed)s, 15 parts of Olibanums, 15 parts of Myrrhas, 28 parts of Herba Taxillis, 25 parts of Cortex erythrinaes, 15 parts of Radix Ginseng Rubra, 15 parts of Oletum Trogopteroris, 15 parts of the Rhizoma Atractylodis Macrocephalaes.
Above-mentioned 16 flavors, Scorpio, Semen Strychni (processed) are ground into fine powder; Scolopendra adds 20 times of simulated gastric fluids, and is airtight, adds 2.5% pepsin after 40 minutes in 37 ℃ of water bath with thermostatic control effects, acts on after 3 hours, places 85 ℃ of water bath with thermostatic control effects after 20 minutes enzymolysis solution, be cooled to room temperature after, centrifugal, get supernatant, standby; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, Scorpio carry out the enzyme bionic extraction with method, respectively get supernatant, and be standby; Above-mentioned supernatant is merged, standby; Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae add 10 times of amounts of water after mixing, and steam distillation 10 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected, and medicinal residues are continued to employ; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 6: 80,40 ℃ were stirred 1.5 hours), cold preservation is spent the night, and filters, and inclusion complex low temperature (40 ℃) drying is ground into fine powder; The Radix Paeoniae Alba, Cortex erythrinae, Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS 5 flavors add 12 times of water gagings and decoct 5 times, and each 2 hours, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge, and suitably concentrate; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 8,6 times of amount 60% alcohol reflux 2 times respectively at every turn, 2 hours for the first time, 1 hour for the second time, merge extractive liquid,, filter, filtrate recycling ethanol also suitably concentrates, and merges with above-mentioned concentrated solution and supernatant, filters, filter, filtrate adding carbomer, glycerol, sorbic acid stir and make dissolving, place, and make abundant swelling, add Semen Strychni, Scorpio fine powder, volatile oil inclusion complex fine powder and add solvent and transfer to full dose, stir, make gel, promptly get gel.
Embodiment 6:
In weight proportion: 30 parts of Zaocyss, 15 parts of stir-baked SQUAMA MANITISs, 15 parts of Cornu Cervi Degelatinatums, 60 parts of the Radix Paeoniae Albas, 10 parts of Scolopendras, 20 parts of Caulis Spatholobis, 15 parts of Rhizoma Drynariae, 10 parts of Fructus Rosae Laevigatae, 5 parts of Semen Strychni Pulveratums, 10 parts of Olibanums, 10 parts of Myrrhas, 20 parts of Herba Taxillis, 15 parts of Cortex erythrinaes, 10 parts of Radix Ginseng Rubra, 10 parts of Oletum Trogopteroris, 20 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 20 parts of Lignum Sappans, 20 parts of Herba speranskiae tuberculataes, 15 parts of Herba Lycopodiis, 20 parts of Radix Puerariaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Radix Rehmanniae Preparata, 50 parts of Magnetitums, 10 parts of Pyritums, 10 parts of Eupolyphaga Seu Steleophagas, 10 parts of Radix Dipsacis, 5 parts of Scorpios
Above-mentioned 31 flavors, Scolopendra, Scorpio are ground into fine powder, and be standby; Olibanum, Myrrha, the Rhizoma Atractylodis Macrocephalae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis add 10 times of amounts of water after mixing, and steam distillation 10 hours extracts volatile oil, and the aqueous solution after distillation device collection is in addition continued to employ; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Fructus Rosae Laevigatae, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Radix Rehmanniae Preparata, Pyritum, Radix Dipsaci, Eupolyphaga Seu Steleophaga, Magnetitum 18 flavors add 12 respectively, 10,10 times of water gagings decoct 3 times, each 2 hours, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, and be concentrated into the thick paste that relative density is 1.10 (50 ℃), Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors add 6 times of amount 70% ethanol, heating and refluxing extraction 3 times, each 2 hours at every turn, merge extractive liquid,, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.05 (50 ℃), with above-mentioned thick paste, Scolopendra, the Scorpio fine powder, Semen Strychni Pulveratum merges, mixing, drying, be ground into fine powder, it is an amount of to add lactose, and mixing is granulated, dry, spray into above-mentioned volatile oil, add 2% Pulvis Talci, mixing, encapsulated, promptly get capsule.
Embodiment 7:
In weight proportion: 25 parts of Zaocyss, 18 parts of stir-baked SQUAMA MANITISs, 8 parts of Cornu Cervi Degelatinatums, 80 parts of the Radix Paeoniae Albas, 12 parts of Fructus Rosae Laevigatae, 8 parts of Scolopendras, 20 parts of Caulis Spatholobis, 25 parts of Rhizoma Drynariae, 6 parts of Semen Strychni (system), 10 parts of Olibanums, 12 parts of Myrrhas, 22 parts of Herba Taxillis, 18 parts of Cortex erythrinaes, 12 parts of Radix Ginseng Rubra, 12 parts of Oletum Trogopteroris, 19 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 5 parts of Radix Clematidis, 12 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Radix Angelicae Pubescentiss, 18 parts of Lignum Sappans
Above-mentioned 21 flavors, Scolopendra, Semen Strychni (processed) are ground into fine powder, and be standby; Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis add 8 times of amounts of water after mixing, and soak 2 hours, and steam distillation 8 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Volatile oil betacyclodextrin inclusion (volatile oil-betacyclodextrin-water=1: 7: 70,30 ℃ were stirred 0.5 hour), cold preservation is spent the night, and filters, and inclusion complex low temperature (50 ℃) drying is ground into fine powder; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Fructus Rosae Laevigatae, Rhizoma Cibotii 7 flavors add 10,8,8,6,6 times of water gagings respectively and decoct 5 times, first three time 3 hours, back secondary 1 hour, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and are concentrated into the thick paste that relative density is 1.05 (60 ℃); Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori add 5 times of amount 80% ethanol, heating and refluxing extraction 8.0 hours, merge extractive liquid,, filter, filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.15 (50 ℃), merges with above-mentioned thick paste, Scolopendra fine powder, Semen Strychni fine powder, volatile oil inclusion complex fine powder, mixing, drying is ground into fine powder, and is standby; Getting stearic acid, glyceryl monostearate, glycerol, triethanolamine, potassium sorbate, Tween-80, PEG-4000 mixes in right amount, be heated to about 80 ℃, slowly be added in the octadecanol that is heated to equality of temperature, hexadecanol mixture, liquid paraffin,light, the dimethicone oil phase, constantly stir and make emulsion bases, above-mentioned medicated powder is dissolved in 30% ethanol, add mixing in the emulsion bases, fill promptly gets ointment.
Embodiment 8:
In weight proportion: 40 parts of Zaocyss, 20 parts of Cornu Cervi Degelatinatums, 20 parts of stir-baked SQUAMA MANITISs, 90 parts of the Radix Paeoniae Albas, 15 parts of Scolopendras, 30 parts of Caulis Spatholobis, 22 parts of Rhizoma Drynariae, 10 parts of Fructus Rosae Laevigatae, 25 parts of Rhizoma Cibotii, 3 parts of Semen Strychni, 12 parts of Olibanums, 12 parts of Myrrhas, 8 parts of Oletum Trogopteroris, 18 parts of Herba Taxillis, 20 parts of Cortex erythrinaes, 10 parts of Radix Ginseng Rubra, 12 parts of Herba Epimedii, 20 parts of Radix Clematidis, 12 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 25 parts of Lignum Sappans, 18 parts of Herba speranskiae tuberculataes, 10 parts of Herba Lycopodiis, 25 parts of Radix Puerariaes, 25 parts in Radix Rehmanniae Preparata, 3 parts of Scorpios
More than 26 the flavor, Scolopendra, Scorpio, Semen Strychni Pulveratum are broken into fine powder, and be standby; Olibanum, Myrrha add 6 times of amounts of water after mixing, and soak 5 hours, and steam distillation 12 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis add 10 times of amounts of water after mixing, and steam distillation 8 hours extracts volatile oil, and the aqueous solution after distillation device is in addition collected; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Puerariae, Radix Rehmanniae Preparata, Fructus Rosae Laevigatae decocts with water 4 times, adding for the first time 14 times of water gagings decocted 2 hours, adding for the second time 12 times of water gagings decocted 2 hours, third and fourth time adds 10 times of water gagings respectively and decocted 1 hour, and collecting decoction filters, filtrate and above-mentioned two aqueous solutions merge, and are concentrated into the thick paste that relative density is 1.02 (50 ℃ of surveys); Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Oletum Trogopterori add 75% ethanol, reflux, extract, 4 times, and alcohol adding amount is respectively 5,4,4,3 times of amounts, extraction time was respectively 2,2,1,0.5 hours, merge extractive liquid, filters, and filtrate recycling ethanol is concentrated into the thick paste that relative density is 1.08 (60 ℃ of surveys); , Radix Ginseng Rubra adds 5 times of amount 85% alcohol reflux 5 hours, filter, filtrate concentrates gained extractum and adds 2 times of water dissolutioies, filter, filtrate is crossed ZTC-1 type macroporous adsorbent resin with the speed of 0.6ml/g medical material .min, uses 5 times of resinite hydrops and 3 times of resin volume 10% alcohol flushing impurity successively, uses 50% alcohol desorption of 4 times of resin volumes then, collect stripping liquid, measuring relative density during decompression recycling ethanol to 60 ℃ is 1.05; Merge with above-mentioned thick paste, Scolopendra, Scorpio, Semen Strychni fine powder, mixing, drying is ground into fine powder, and adding hyprolose and Heavy Magnesium Carbonate are an amount of, and mixing is granulated, and drying adds 0.5% magnesium stearate, sprays into above-mentioned two kinds of volatile oil, and tabletting promptly gets tablet.
Embodiment 9:
In weight proportion: 10 parts of Zaocyss, 5 parts of stir-baked SQUAMA MANITISs, 5 parts of Cornu Cervi Degelatinatums, 20 parts of the Radix Paeoniae Albas, 3 parts of Scolopendras, 5 parts of Fructus Rosae Laevigatae, 6 parts of Caulis Spatholobis, 5 parts of Rhizoma Drynariae, 2 parts of Semen Strychni (system), 5 parts of Olibanums, 5 parts of Myrrhas, 12 parts of Herba Taxillis, 5 parts of Cortex erythrinaes, 5 parts of Radix Ginseng Rubra, 5 parts of Oletum Trogopteroris, 12 parts of Rhizoma Cibotii, 5 parts of Herba Epimedii, 5 parts of Radix Clematidis, 5 parts of Rhizoma Et Radix Notopterygiis, 5 parts of Radix Angelicae Pubescentiss, 12 parts of Lignum Sappans, 12 parts of Herba speranskiae tuberculataes, 5 parts of Herba Lycopodiis, 5 parts of Radix Dipsacis, 2 parts of Scorpios
Above-mentioned 25 flavor medicines, Semen Strychni (processed), Scolopendra, Scorpio dilution are loose at double, and Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis 4 flavors extract volatile oil; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Dipsaci 15 flavors carry out water to be carried, and water extract and the above-mentioned aqueous solution of carrying behind the oil are condensed into thick paste; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra carry out alcohol extraction, and alcohol extract is condensed into thick paste, and above-mentioned thick paste is ground into fine powder, add an amount of mannitol, 5% aspartame, 3% essence, 5% Pulvis Talci, mixing, and packing makes powder.
Actual conditions such as required extraction temperature, solvent load, extraction time, extraction time during extraction can be by testing screened obtaining.
Embodiment 10:
In weight proportion: 35 parts of Zaocyss, 18 parts of Cornu Cervi Degelatinatums, 18 parts of stir-baked SQUAMA MANITISs, 40 parts of the Radix Paeoniae Albas, 12 parts of Scolopendras, 7 parts of Fructus Rosae Laevigatae, 15 parts of Caulis Spatholobis, 10 parts of Rhizoma Drynariae, 4 parts of Semen Strychni (processed)s, 12 parts of Olibanums, 8 parts of Myrrhas, 15 parts of Herba Taxillis, 20 parts of Cortex erythrinaes, 8 parts of Radix Ginseng Rubra, 8 parts of Oletum Trogopteroris, 16 parts of Rhizoma Cibotii, 14 parts of Herba Epimedii, 12 parts of Radix Clematidis, 6 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Radix Angelicae Pubescentiss, 12 parts of Lignum Sappans, 5 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts in Radix Rehmanniae Preparata, 8 parts of Radix Dipsacis, 6 parts of Scorpios, 8 parts of Herba speranskiae tuberculataes, 8 parts of Herba Lycopodiis
Above-mentioned 27 flavors, Scolopendra, Scorpio, Semen Strychni (processed) are ground into fine powder, and Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Rhizoma Atractylodis Macrocephalae 5 flavors extract volatile oil; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Radix Rehmanniae Preparata, Radix Dipsaci, Fructus Rosae Laevigatae, Herba speranskiae tuberculatae, Herba Lycopodii 14 flavors carry out water to be carried, and water extract and the above-mentioned aqueous solution of carrying behind the oil are condensed into thick paste; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors carry out alcohol extraction, and alcohol extract is condensed into thick paste, and above-mentioned two thick pastes and Scolopendra, Scorpio fine powder, Semen Strychni (processed) are ground into fine powder, and prepared becomes chewable tablet routinely.
Actual conditions such as required extraction temperature, solvent load, extraction time, extraction time during extraction can be by testing screened obtaining.The utilization common process is made pill.
Embodiment 11:
In weight proportion: 25 parts of Zaocyss, 10 parts of stir-baked SQUAMA MANITISs, 15 parts of Cornu Cervi Degelatinatums, 50 parts of the Radix Paeoniae Albas, 12 parts of Scolopendras, 15 parts of Caulis Spatholobis, 6 parts of Fructus Rosae Laevigatae, 3 parts of Semen Strychni Pulveratums, 6 parts of Olibanums, 12 parts of Myrrhas, 12 parts of Rhizoma Drynariae, 18 parts of Herba Taxillis, 8 parts of Cortex erythrinaes, 15 parts of Radix Ginseng Rubra, 10 parts of Rhizoma Cibotii, 8 parts of Herba Epimedii, 8 parts of Radix Clematidis, 6 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Radix Angelicae Pubescentiss, 15 parts of Lignum Sappans, 20 parts of Herba speranskiae tuberculataes, 16 parts of Herba Lycopodiis, 28 parts of Pachyrhizua angulatus, 6 parts of the Rhizoma Atractylodis Macrocephalaes, 25 parts in Radix Rehmanniae Preparata, 10 parts of Radix Dipsacis, 6 parts of Oletum Trogopteroris, 30 parts of Magnetitums, 4 parts of Scorpios
Above-mentioned 25 flavors, Scolopendra, Scorpio are ground into fine powder; Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Rhizoma Atractylodis Macrocephalae 5 flavors extract volatile oil; Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, the Radix Paeoniae Alba, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Fructus Rosae Laevigatae, Radix Clematidis, Lignum Sappan, Herba speranskiae tuberculatae, Herba Lycopodii, Radix Rehmanniae Preparata, Radix Dipsaci, Pachyrhizua angulatus, Magnetitum 16 flavors carry out water and carry, water extract and the above-mentioned aqueous solution of carrying behind the oil are condensed into thick paste; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors carry out alcohol extraction, and alcohol extract is condensed into thick paste, and two thick pastes mix with above-mentioned Scolopendra, Scorpio fine powder, Semen Strychni fine powder, and drying is ground into fine powder, and is standby; By 3: 1 taking polyethylene glycols 6000 and Macrogol 4000 heating and melting, stir and make dissolving, add above-mentioned medicated powder, mixing is transferred in the reservoir, in 80 ± 2 ℃ of insulations.With the water dropper in 3mm aperture, regulate to drip apart from being 6～8cm, control is dripped speed and is about 50 of per minutes, splashes in 5～10 ℃ the dimethicone, treats that drop pill cooling back takes out, and drop to the greatest extent and wipe dimethicone promptly gets drop pill.
Actual conditions such as required extraction temperature, solvent load, extraction time, extraction time during extraction can be by testing screened obtaining.
Embodiment 12:
In weight proportion: 15 parts of Zaocyss, 10 parts of stir-baked SQUAMA MANITISs, 12 parts of Cornu Cervi Degelatinatums, 45 parts of the Radix Paeoniae Albas, 12 parts of Scolopendras, 25 parts of Caulis Spatholobis, 10 parts of Fructus Rosae Laevigatae, 2 parts of Semen Strychni, 6 parts of Olibanums, 6 parts of Myrrhas, 18 parts of Rhizoma Drynariae, 25 parts of Herba Taxillis, 18 parts of Cortex erythrinaes, 6 parts of Radix Ginseng Rubra, 20 parts of Rhizoma Cibotii, 10 parts of Herba Epimedii, 15 parts of Radix Clematidis, 10 parts of Rhizoma Et Radix Notopterygiis, 10 parts of Radix Angelicae Pubescentiss, 20 parts of Lignum Sappans, 12 parts of Pachyrhizua angulatus, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts in Radix Rehmanniae Preparata, 10 parts of Radix Dipsacis, 5 parts of Scorpios, 8 parts of Oletum Trogopteroris
Above-mentioned 26 flavors, Scolopendra, Scorpio, Semen Strychni Pulveratum are broken into fine powder, and Olibanum, Myrrha, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, the Rhizoma Atractylodis Macrocephalae 5 flavors extract volatile oil; Medicinal residues and Cornu Cervi Degelatinatum, Zaocys, stir-baked SQUAMA MANITIS, Fructus Rosae Laevigatae, the Radix Paeoniae Alba, Cortex erythrinae, Rhizoma Cibotii, Herba Epimedii, Radix Clematidis, Lignum Sappan, Radix Rehmanniae Preparata, Radix Dipsaci 12 flavors carry out water to be carried, and water extract and the above-mentioned aqueous solution of carrying behind the oil are condensed into thick paste; Caulis Spatholobi, Herba Taxilli, Rhizoma Drynariae, Radix Ginseng Rubra, Oletum Trogopterori 5 flavors carry out alcohol extraction, and alcohol extract is condensed into thick paste, and above-mentioned two thick pastes mix with Scolopendra, Scorpio fine powder, Semen Strychni fine powder, and drying is ground into fine powder, and prepared becomes pill routinely.
Actual conditions such as required extraction temperature, solvent load, extraction time, extraction time during extraction can be by testing screened obtaining.
Preparation with above-mentioned active drug feedstock production obtains carries out following correlation test.
1, analgesic test---to the influence of mouse writhing reaction
Get 70 of mices, be divided into matched group, medicine embodiment of the present invention 1 gained tablet group (middle dosage group) at random, embodiment 2 gained granule groups (dosage group less than normal), embodiment 3 gained dispersible tablet groups (dosage group bigger than normal), embodiment 5 gained gel groups (heavy dose of group), embodiment 6 gained capsule groups (middle dosage group), embodiment 9 gained powder groups (small dose group), every day, gastric infusion was 1 time, successive administration 5 days, and matched group is irritated stomach and is given with the volume distilled water.Each was organized in the last administration after 30 minutes, every animal difference lumbar injection 0.6% glacial acetic acid solution 0.1ml/10g, mouse writhing number of times (in the 10min) behind the record injection glacial acetic acid then.
The result is as follows:
Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Group dosage (g/kg) mice quantity (n) is turned round the body number of times
Contrast-10 35.26 ± 7.12
Powder group 5 10 29.11 ± 8.25
Granule group 5 10 26.37 ± 6.89
Tablet group 5 10 23.75 ± 9.13
Capsule group 5 10 19.48 ± 10.14
Dispersible tablet group 5 10 16.75 ± 6.22
Gel group 5 10 13.25 ± 4.87
Annotate: compare P＜0.05 with matched group.
The result shows that the above-mentioned dosage form group of the present invention all can reduce the acetic acid induced mice significantly and turn round the body number of times, shows that medicine of the present invention has significant analgesic activity to the pain due to the chemical stimulation.
2, antiinflammatory test---xylol causes the influence of mice ear
Get 80 of mices, be divided into matched group, medicine embodiment of the present invention 1 gained tablet group (middle dosage group) at random, embodiment 2 gained granule groups (dosage group less than normal), embodiment 3 gained dispersible tablet groups (dosage group bigger than normal), embodiment 5 gained gel groups (heavy dose of group), embodiment 6 gained capsule groups (middle dosage group), embodiment 9 gained powder groups (small dose group), Dexamethasone group, every day, gastric infusion was 1 time, successive administration 5 days, matched group is irritated stomach and is given with the volume distilled water.Each was organized in the last administration after 1 hour, and dimethylbenzene 0.05ml is smeared in ear innner and outer sides, a mice left side, and auris dextra is not painted with normal control.The dislocation of mice cervical vertebra is put to death after 1 hour, cuts the bilateral auricle, sweeps away round auricle at the same position of bilateral auricle respectively with the 8.25mm card punch, and analytical balance is weighed.Press the following formula formula and calculate the mice ear degree.
Swelling degree=left ear ear weight-auris dextra ear is heavy
The result is as follows:
Xylol causes the influence of mice ear
Heavy (mg) swelling degree (mg) of heavy (mg) auris dextra of the left ear of group dosage (g/kg)
Contrast-29.11 ± 2.51 18.85 ± 1.36 12.26 ± 1.85
Powder group 5 26.89 ± 3.18 16.78 ± 4.53 10.11 ± 3.89
Granule group 5 24.12 ± 4.76 15.11 ± 3.25 9.01 ± 4.02
Tablet group 5 22.58 ± 3.26 11.59 ± 4.71 10.99 ± 4.26
Capsule group 5 19.47 ± 3.38 9.94 ± 4.11 9.53 ± 3.75
Dispersible tablet group 5 20.04 ± 3.02 10.65 ± 1.25 9.39 ± 2.05
Gel group 5 19.81 ± 3.79 10.46 ± 1.47 9.35 ± 2.17
Dexamethasone 5mg/kg 14.65 ± 2.86 7.35 ± 0.87 7.3 ± 1.63
Annotate: compare P＜0.05 with matched group.
The result shows that the above-mentioned dosage form group of medicine of the present invention all can significantly reduce the inflammatory reaction of mice caused by dimethylbenzene xylene ear swelling; Show that it has the obvious suppression reaction to non-specially property inflammation.

Claims (10)

1. medicine for the treatment of cervical spondylosis, it is characterized in that, by weight, the crude drug of making this effective ingredient contains: Zaocys 10-50 part, stir-baked SQUAMA MANITIS 5-25 part, Cornu Cervi Degelatinatum 5-25 part, Radix Paeoniae Alba 20-100 part, Fructus Rosae Laevigatae 5-15 part, Scolopendra 3-17 part, Caulis Spatholobi 6-34 part, Rhizoma Drynariae 5-25 part, Semen Strychni or Semen Strychni (processed) 2-8 part, Olibanum 5-15 part, Myrrha 5-15 part, Herba Taxilli 12-28 part, Cortex erythrinae 5-25 part, Radix Ginseng Rubra 5-15 part, Oletum Trogopterori 5-15 part.
2. a kind of medicine for the treatment of cervical spondylosis according to claim 1, it is characterized in that, by weight, the crude drug of making this effective ingredient contains: Zaocys 20-40 part, Cornu Cervi Degelatinatum 10-20 part, stir-baked SQUAMA MANITIS 10-20 part, Radix Paeoniae Alba 50-70 part, Fructus Rosae Laevigatae 8-12 part, Scolopendra 5-15 part, Caulis Spatholobi 15-25 part, Rhizoma Drynariae 10-20 part, Semen Strychni or Semen Strychni (processed) 3-7 part, Olibanum 8-12 part, Myrrha 8-12 part, Herba Taxilli 15-25 part, Cortex erythrinae 10-20 part, Radix Ginseng Rubra 8-12 part, Oletum Trogopterori 8-12 part.
3. a kind of medicine for the treatment of cervical spondylosis according to claim 1, it is characterized in that, by weight, the crude drug of making this effective ingredient also comprises: one or more in Herba Epimedii 5-15 part, Radix Clematidis 5-25 part, Rhizoma Et Radix Notopterygii 5-15 part, Radix Angelicae Pubescentis 5-15 part, Lignum Sappan 12-28 part, Herba speranskiae tuberculatae 12-28 part, Herba Lycopodii 5-25 part, Radix Puerariae 12-28 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Radix Rehmanniae Preparata 12-28 part, Pyritum 5-15 part, Radix Dipsaci 5-15 part, Rhizoma Cibotii 12-28 part, Scorpio 2-8 part, Eupolyphaga Seu Steleophaga 5-15 part, Magnetitum 10-90 part.
4. a kind of medicine for the treatment of cervical spondylosis according to claim 3, it is characterized in that, by weight, the crude drug of making this effective ingredient also comprises: one or more in Herba Epimedii 8-12 part, Radix Clematidis 10-20 part, Rhizoma Et Radix Notopterygii 8-12 part, Radix Angelicae Pubescentis 8-12 part, Lignum Sappan 15-25 part, Herba speranskiae tuberculatae 15-25 part, Herba Lycopodii 10-20 part, Radix Puerariae 15-25 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Radix Rehmanniae Preparata 15-25 part, Pyritum 8-12 part, Radix Dipsaci 8-12 part, Rhizoma Cibotii 15-25 part, Scorpio 3-7 part, Eupolyphaga Seu Steleophaga 8-12 part, Magnetitum 35-65 part.
5. according to any described a kind of medicine for the treatment of cervical spondylosis of claim 1-4, it is characterized in that described preparation is oral formulations and external preparation; Wherein oral formulations is meant tablet, capsule, granule, pill, powder, oral liquid; External preparation is meant unguentum, gel, liniment, lotion, liniment.
6. a kind of medicine for the treatment of cervical spondylosis according to claim 5 is characterized in that described tablet is meant conventional tablet, dispersible tablet, effervescent tablet, oral cavity disintegration tablet, buccal tablet, chewable tablet; Described capsule is meant hard capsule, soft capsule; Described pill is meant drop pill; Described unguentum is meant ointment, cataplasma, emplastrum.
7. according to any described a kind of preparation method for the treatment of the medicine of cervical spondylosis among the claim 1-4, it is characterized in that it comprises each crude drug is cleaned respectively, pulverizes, and mixes.
8. according to any described a kind of preparation method for the treatment of the medicine of cervical spondylosis among the claim 1-4, it is characterized in that, it comprises each crude drug, add water or Different concentrations of alcohol or enzyme bionic extraction respectively, the extracting solution concentrate drying gets extract, or further adopt alcohol deposition method, water returns molten method, organic solvent extractionprocess, flocculent precipitation, column chromatography one or more unite use carry out after suitably refining extract; With above-mentioned crude extract or extract directly be used as medicine take or add on the pharmaceutics acceptable auxiliary routinely prepared become required preparation.
9. described according to Claim 8 a kind of preparation method for the treatment of the medicine of cervical spondylosis is characterized in that, described adjuvant is meant and adds diluent, disintegrating agent, binding agent, lubricant, surfactant, filler commonly used in solid preparation; In the liquid preparation form, add surfactant, diluent, antiseptic, stabilizing agent, correctives, thickening agent, fluidizer commonly used; In the external dosage form, add antiseptic, antioxidant, wetting agent, Percutaneous absorption enhancer, surfactant commonly used.
10. according to any described a kind of application of medicine in preparation treatment cervical spondylosis medicine for the treatment of cervical spondylosis among the claim 1-4.
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CN104127647B (en) * 2014-08-18 2017-05-24 河南中医学院 Traditional Chinese medicine decoction for treating vertebral artery type of cervical spondylosis
CN104491578B (en) * 2014-12-15 2017-11-24 陈中元 A kind of medicine for treating cervical spondylopathy and its preparation
CN105853657A (en) * 2016-06-06 2016-08-17 侯文平 External-application traditional Chinese medicine for improvement and reunion of ligaments and muscles and using method thereof
CN106691050A (en) * 2017-01-09 2017-05-24 李志乾 Cervical vertebra rehabilitation pillow with traditional Chinese medicines
CN107582952A (en) * 2017-10-30 2018-01-16 贵州瑞丰源农业科技开发有限公司 A kind of medicine for treating cervical spondylopathy and preparation method thereof
CN113425746A (en) * 2021-06-25 2021-09-24 楚东开 Composition for treating pyogenic osteomyelitis and preparation method thereof

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