CN101375989B - Anti-inflammation formulation for treating hyperplastic prostate gland and preparation method thereof - Google Patents
Anti-inflammation formulation for treating hyperplastic prostate gland and preparation method thereof Download PDFInfo
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- CN101375989B CN101375989B CN2008101519369A CN200810151936A CN101375989B CN 101375989 B CN101375989 B CN 101375989B CN 2008101519369 A CN2008101519369 A CN 2008101519369A CN 200810151936 A CN200810151936 A CN 200810151936A CN 101375989 B CN101375989 B CN 101375989B
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Abstract
The invention relates to a preparation with antiphlogistic effect for treating hyperplasia of prostate, and a preparation method thereof. The preparation is prepared from the following Chinese traditional medicines by weight: Fritillaria thunbergii 20-70, Prunella vulgaris 80-180, Thallus Laminariae and/or Thallus Eckloniae 60-160, Rhizoma Cimicifugae 15-35, Sargassum 75-155, pumice 50-100, Panaxginseng 5-15, Astragalus membranaceus 100-200, Cinnamomum cassia twig 25-75, Salvia miltiorrhiza 70-160, Liquidambar formosana 50-100, Leonurus heterophyllus 80-210, Semen Plantaginis 50-110, Scutellaria baicalensis 70-150, and Achyranthes bidentata 30-60. The effective ingredients of the raw materials in the preparation are extracted by decoction, and activities thereof are remained, so as to remarkably improve the dissolution rate, promote absorption of the effective ingredients, and further improve bioavailability. In addition, the preparation is a pure Chinese medicinal preparation, thereby resulting in good safety and no toxic or side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly relate to a kind of with Chinese medicine be raw material make be used for the treatment of anti-inflammation formulation of prostatic hyperplasia and preparation method thereof.
Background technology
Prostatic hyperplasia is to cause a kind of disease the most common in the middle-aging male dysuria reason.Though in TCM Document, do not have this title of hyperplasia of prostate, the symptom of hyperplasia of prostate had understanding very early.From symptom, sign, hyperplasia of prostate is equivalent to the difficulty in urination category of Chinese medicine.The difficulty in urination is meant that urine amount is few, drop and going out, very then urine inaccessible obstructed is a kind of illness of primary symptom.Wherein again with dysuria, drop and being short of, the slow person of patient's condition is called " infirmity "; With the obturation of urinating, drop is obstructed, and the more anxious person of patient's condition is called " closing ".Though it is many to be used for the treatment of the types of drugs of prostatic hyperplasia at present clinically, specific aim is not strong, and the toxic and side effects of some medicine is big, so take back DeGrain for treatment belongs to this disease of type of stagnation of turbid phlegm and blood stasis prostatic hyperplasia.
Summary of the invention
In order to address the above problem, the object of the present invention is to provide a kind of treatment type of stagnation of turbid phlegm and blood stasis prostatic hyperplasia effect obvious, thereby with strong points, and the anti-inflammation formulation that is used for the treatment of prostatic hyperplasia that has no side effect.
Another object of the present invention is to provide a kind of method that is used to prepare above-mentioned anti-inflammation formulation.
In order to achieve the above object, the anti-inflammation formulation that is used for the treatment of prostatic hyperplasia provided by the invention is that the following medicine material of weight ratio is made by consumption mainly:
Bulbus Fritillariae Thunbergii 20-70 Spica Prunellaes 80-180 Thallus Laminariae (Thallus Eckloniae)s 60-160
Rhizoma Cimicifugae 15-35 Sargassums 75-155 Pumexs 50-100
Radix Ginseng Rubra 5-15 Radixs Astragali 100-200 Ramulus Cinnamomi 25-75
Radix Salviae Miltiorrhizae 70-160 Fructus Liquidambaris 50-100 Herba Leonuris 80-210
Semen Plantaginis 50-110 Radix Scutellariaes 70-150 Radix Achyranthis Bidentataes 30-60
The described preparation method that is used for the treatment of the anti-inflammation formulation of prostatic hyperplasia is to carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Ginseng Rubra full dose, Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, each 1/3rd amount of Ramulus Cinnamomi are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, 11 kinds of medicine materials of Ramulus Cinnamomi and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
The anti-inflammation formulation that is used for the treatment of prostatic hyperplasia provided by the invention is that the method for employing decocting in water extraction is extracted the effective ingredient in the material medicine, and keep its activity, can make so not only that the dissolution of effective ingredient improves greatly in the medicine, and help the absorption of medicine, thereby can improve its bioavailability.In addition, medicine of the present invention is a pure Chinese medicinal preparation, thereby the patient can not produce toxic and side effects after taking for a long time, so safety is good.In addition, preparation method technology of the present invention is simple, easy to operate.
The specific embodiment
Old prostatic hyperplasia, from pathogenesis when duty in the deterioration of spleen, kidney, lung, due to water channel is obstructed, this be disease, so phlegm and blood stasis is condensed into piece, functioning of bladder is obstructed and is its key.We make laws in hard masses softening and resolving, and blood circulation promoting and blood stasis dispelling is held concurrently with warming the kidney and strengthening the spleen, and the stagnation resolvation knot is loose, and the functioning of bladder function is recovered, and urine is by being able to tonneau.The Spica Prunellae toil is cold in the side, clearing away liver-fire, Disperse hepatic depression; Bulbus Fritillariae Thunbergii bitter cold, heat clearing away eliminating stagnation are monarch.The Sargassum hardship is salty-cold, hard masses softening and resolving; Thallus Laminariae (Thallus Eckloniae) is salty-cold, hard masses softening and resolving, expectorant, diuretic; Pumex is salty flat, hard masses softening and resolving, removing heat from the lung and dissipating phlegm, this three medicines and usefulness, the more power of repercussive eliminating stagnation in the reinforcement side.The sweet temperature of Radix Ginseng Rubra, strongly invigorating primordial QI; The sweet tepor of the Radix Astragali, tonifying Qi and lifting yang; The Rhizoma Cimicifugae suffering is slightly cold, the energy ascending up spleen-Qi and Yang; The hot temperature of Ramulus Cinnamomi, warming the meridian for promoting the flow of YANG QI.Four medicines share the merit that can reach the spleen invigorating warming the meridian, more than all medicines be ministerial drug altogether.Semen Plantaginis is sweet to be slightly cold relieving stranguria by diuresis; Fructus Liquidambaris is hot flat, the diuretic dehumidifying; The Radix Salviae Miltiorrhizae hardship is slightly cold, blood circulation promoting and blood stasis dispelling, disease eliminating powder junction; The Herba Leonuri suffering is slightly cold, blood circulation promoting and blood stasis dispelling, diuresis, detoxifcation; The Radix Scutellariae bitter cold, heat clearing and damp drying, the medicine-feeding blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis is an adjuvant drug.The Radix Achyranthis Bidentatae suffering is slightly cold, blood circulation promoting and blood stasis dispelling, and conducting blood to flow downwards is done the through disease of all medicines and is made.
Below in conjunction with embodiment anti-inflammation formulation that is used for the treatment of prostatic hyperplasia provided by the invention and preparation method thereof is elaborated.
Embodiment 1:
The anti-inflammation formulation that is used for the treatment of prostatic hyperplasia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Bulbus Fritillariae Thunbergii 40 Spica Prunellaes 120 Thallus Laminariae (Thallus Eckloniae)s 120
Rhizoma Cimicifugae 20 Sargassums 120 Pumexs 80
Radix Ginseng Rubra 9 Radixs Astragali 160 Ramulus Cinnamomi 40
Radix Salviae Miltiorrhizae 120 Fructus Liquidambaris 80 Herba Leonuris 160
Semen Plantaginis 80 Radix Scutellariaes 120 Radix Achyranthis Bidentataes 40
Preparation method:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Ginseng Rubra full dose, Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, each 1/3rd amount of Ramulus Cinnamomi are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, 11 kinds of medicine materials of Ramulus Cinnamomi and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
Embodiment 2:
The anti-inflammation formulation that is used for the treatment of prostatic hyperplasia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Bulbus Fritillariae Thunbergii 20 Spica Prunellaes 80 Thallus Laminariae (Thallus Eckloniae)s 60
Rhizoma Cimicifugae 15 Sargassums 75 Pumexs 50
Radix Ginseng Rubra 5 Radixs Astragali 100 Ramulus Cinnamomi 25
Radix Salviae Miltiorrhizae 70 Fructus Liquidambaris 50 Herba Leonuris 80
Semen Plantaginis 50 Radix Scutellariaes 70 Radix Achyranthis Bidentataes 30
Preparation method is with embodiment 1.
Embodiment 3:
The anti-inflammation formulation that is used for the treatment of prostatic hyperplasia in the present embodiment is that the following medicine material of weight ratio is made by consumption mainly:
Bulbus Fritillariae Thunbergii 70 Spica Prunellaes 180 Thallus Laminariae (Thallus Eckloniae)s 160
Rhizoma Cimicifugae 35 Sargassums 155 Pumexs 100
Radix Ginseng Rubra 15 Radixs Astragali 200 Ramulus Cinnamomi 75
Radix Salviae Miltiorrhizae 160 Fructus Liquidambaris 100 Herba Leonuris 210
Semen Plantaginis 110 Radix Scutellariaes 150 Radix Achyranthis Bidentataes 60
Preparation method is with embodiment 1.
The anti-inflammation formulation that is used for the treatment of prostatic hyperplasia provided by the invention is brown to sepia; Feeble QI, it is little sweet to distinguish the flavor of.In order to verify the therapeutic effect of this anti-inflammation formulation, the patient that the inventor utilizes the capsule that belongs to oral solid formulation in the above-mentioned anti-inflammation formulation that 278 examples are suffered from the type of stagnation of turbid phlegm and blood stasis prostatic hyperplasia has carried out system's clinical observation, 3 of each medications, every day 2 times, 60 days is 1 course of treatment.After 1 course of therapy, cure (prostatic examination is normal, and cardinal symptom is obviously improved) 72 examples altogether, account for 25.9%; Effectively (prostatic examination makes moderate progress, and cardinal symptom has improvement) 122 examples account for 43.9%; Invalid (prostatic examination does not have significant change, and cardinal symptom does not have improvement) 84 examples account for 30.2%; Total effective rate is 69.8%.After 2 course of therapy, cure 107 examples altogether, account for 38.5%; Effective 117 examples account for 40.1%; Invalid 54 examples account for 19.4%; Total effective rate is 80.6%.
Simultaneously, the inventor analyzes therapeutic effect and the relation between the course of treatment, and analysis result sees Table 1.
Table 1: anti-inflammation formulation therapeutic effect provided by the invention and the course of treatment relation table
With the data x in the above-mentioned table 1
2Method of inspection calculates, and the result is P＜0.005, can prove that thus taking anti-inflammation formulation provided by the invention treats the type of stagnation of turbid phlegm and blood stasis prostatic hyperplasia, and along with going deep into of treatment, cure rate, effective percentage all obviously improve.
Claims (2)
1. anti-inflammation formulation that is used for the treatment of prostatic hyperplasia is characterized in that: the active component of preparation is that the following medicine material of weight ratio is made by consumption:
Bulbus Fritillariae Thunbergii 20-70 Spica Prunellae 80-180 Thallus Laminariae (Thallus Eckloniae) 60-160
Rhizoma Cimicifugae 15-35 Sargassum 75-155 Pumex 50-100
Radix Ginseng Rubra 5-15 Radix Astragali 100-200 Ramulus Cinnamomi 25-75
Radix Salviae Miltiorrhizae 70-160 Fructus Liquidambaris 50-100 Herba Leonuri 80-210
Semen Plantaginis 50-110 Radix Scutellariae 70-150 Radix Achyranthis Bidentatae 30-60.
2. preparation method that is used for the treatment of the anti-inflammation formulation of prostatic hyperplasia as claimed in claim 1 is characterized in that: carry out according to the following step order:
(a) the said medicine raw material is carried out weighing according to proportioning, then with the Radix Ginseng Rubra full dose, Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, each 1/3rd amount of Ramulus Cinnamomi are ground into fine powder and are uniformly mixed into the fine powder mixture;
(b) remaining Bulbus Fritillariae Thunbergii, Radix Salviae Miltiorrhizae, 11 kinds of medicine materials of Ramulus Cinnamomi and other are decocted with water 2 times after mixing, each 2 hours, merging filtrate filtered, and is concentrated into thick paste;
(c) add the fine powder mixture of making in the step (a) in the thick paste of in step (b), making, then according to the pharmaceutical technology of routine and add corresponding common medicinal supplementary material and make oral solid formulation, oral liquid.
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| CN2008101519369A CN101375989B (en) | 2008-09-27 | 2008-09-27 | Anti-inflammation formulation for treating hyperplastic prostate gland and preparation method thereof |
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| CN2008101519369A CN101375989B (en) | 2008-09-27 | 2008-09-27 | Anti-inflammation formulation for treating hyperplastic prostate gland and preparation method thereof |
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| CN101375989B true CN101375989B (en) | 2010-12-08 |
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| CN105853503A (en) * | 2016-03-22 | 2016-08-17 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating prostatic hyperplasia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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Application publication date: 20090304 Assignee: TIANJIN KAIYONG PHARMACEUTICAL Co.,Ltd. Assignor: Cao Kaiyong Contract record no.: 2011120000072 Denomination of invention: Anti-inflammation formulation for treating hyperplastic prostate gland and preparation method thereof Granted publication date: 20101208 License type: Exclusive License Record date: 20110526 |
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Effective date of registration: 20170607 Address after: 300210 Tianjin city Hexi District Liberation Road No. 447 Patentee after: Tianjin Caokaiyong Hospital of traditional Chinese Medicine Address before: Yingkou Heping District 300040 Tianjin City Road 36 No. E119 Patentee before: Cao Kaiyong |
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