CN105770537A - Medicine preparation for treating anxiety disorder and preparation method thereof - Google Patents

Medicine preparation for treating anxiety disorder and preparation method thereof Download PDF

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Publication number
CN105770537A
CN105770537A CN201610204219.2A CN201610204219A CN105770537A CN 105770537 A CN105770537 A CN 105770537A CN 201610204219 A CN201610204219 A CN 201610204219A CN 105770537 A CN105770537 A CN 105770537A
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parts
radix
pharmaceutical preparation
anxiety neurosis
treating anxiety
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邱发龙
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/88—Liliopsida (monocotyledons)
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Abstract

The invention relates to a medicine preparation for treating anxiety disorder and a preparation method thereof. The medicine preparation is prepared from the following components in parts by weight: 10-20 parts of radix rehmanniae praeparata, 10-20 parts of angelica sinensis, 12-25 parts of radix bupleuri, 6-15 parts of licorice root, 10-18 parts of semen ziziphi spinosae, 10-15 parts of lily, 6-15 parts of dragon bone, 10-20 parts of poria cocos, 6-12 parts of pinellia ternata, 10-15 parts of polygala tenuifolia, 10-15 parts of tuber fleeceflower stems, 10-20 parts of salvia miltiorrhiza, 20-30 parts of nacre mother of pearl, 20-50 parts of fructus tritici levis, 3-10 parts of Chinese dates, 10-20 parts of rhizoma cyperi and 3-12 parts of dried ginger, wherein the semen ziziphi spinosae, tuber fleeceflower stems, polygala tenuifolia, dragon bone, salvia miltiorrhiza, lily and nacre mother of pearl have the effects of calming and tranquilizing, the poria cocos, pinellia ternata and polygala tenuifolia have the effects of drying dampness and eliminating phlegm, the radix rehmanniae praeparata, angelica sinensis and Chinese dates can be used for nourishing yin and blood, and the radix bupleuri and radix paeoniae alba can be used for relieving the depressed liver. The medicine preparation focuses on treatment of the malaise primary symptom of the anxiety disorder, further takes medication characteristics of yin-blood deficiency, qi depression, phlegm stagnation and other diseases into consideration, has a good anxiety disorder treatment effect and no toxic or side effect, and is convenient for popularization and application.

Description

A kind of pharmaceutical preparation treating anxiety neurosis and preparation method thereof
Technical field
The invention belongs to tcm field, especially relate to a kind of pharmaceutical preparation treating anxiety neurosis and preparation method thereof.
Background technology
In recent years, along with factors effects such as socioeconomic fast development, social work, inter personal contact, economic pressures Impact, people generally feel heavy stress.Entering 21 century, Mental Health is paid close attention to oneself from traditional by people Heavy mental disorder such as schizophrenia, gradually changes to light-duty mental disorder such as neurosis.Anxiety neurosis is as neurosal one Individual hypotype, its sickness rate is in China in ascendant trend year by year, and healthy impact is increasingly subject to by the Negative Emotional state such as anxiety The concern of people.Its clinical manifestations mainly has two kinds: the first be generalized anxiety disorder (GAD), GAD be anxiety neurosis The most commonly seen form of expression, patient would generally occur xerostomia, cardiopalmus, frequent micturition, slightly tremble, urgent micturition and headache, out of breath, The symptoms such as perspiration, uneasy in either sitting or lying；The second form of expression is panic disorder (PD), when patient is in without special phobia place During border, terrified experience can be experienced, and accompany by strong dying sense or sense out of control, autonomic nervous function can be produced disorderly simultaneously Disorderly.According to relevant report, the patient of anxiety disorder has reached the 15%-30% of whole crowd, and along with people's work and life Continuous quickening, the intensified competitions etc. that movable joint is played, the sickness rate of this disease is also persistently rising.In recent years, anxiety obstacle is more Get over and paid attention to by numerous medical personnels and research worker.
Modern medicine shows for the study of incident mechanism of anxiety neurosis: anxiety neurosis is that various biological modifications etc. are multifactorial alternately Effect, the multiple tissue of human body and organ jointly participates in and neuroendocrine, the interactive result of immune system.But by More complicated in its cause of disease and pathophysiological mechanism, so up to the present, also fail to enough causes of disease illustrating this disease completely and Pathophysiological mechanism.At present, western medicine anxiety neurosis is mainly based on Benzodiazepines, buspirone etc., but Western medicine Easily produce tolerance, the phenomenon of compliance difference, and after drug discontinuation, easily cause withdrawal symptom.And Chinese medicine is from organic conception Setting out, application seven emotions theory of causing a disease has obvious advantage in terms of understanding and treatment anxiety neurosis, and untoward reaction is less, curative effect Definitely, the side effect of Western medicine can be alleviated.Therefore, one of important topic of anxiety research field would is that searching side effect little, The anxiolytic drugs of determined curative effect.
Summary of the invention
The present invention, according to theory of Chinese medical science and modern pharmacological research result, considers prescription, is configured to Chinese medicine preparation, has mind calming peace God, depressed liver-energy dispersing and QI regulating, nourishing YIN and supplementing blood, removing dampness effect of eliminating the phlegm.Anxiety neurosis is had certain treatment and controls effect.
Specifically, the technical scheme is that and be achieved in that:
A kind of pharmaceutical preparation treating anxiety neurosis, includes according to weight fraction ratio:
Radix Rehmanniae Preparata 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Bupleuri 12-25 part, Radix Glycyrrhizae 6-15 part, Semen Ziziphi Spinosae 10-18 part, Bulbus Lilii 10-15 part, Os Draconis 6-15 part, Poria 10-20 part, Rhizoma Pinelliae 6-12 part, Radix Polygalae 10-15 part, Caulis Polygoni Multiflori 10-15 part is red Ginseng 10-20 part, Concha Margaritifera 20-30 part, Fructus Tritici Levis 20-50 part, 3-10 piece of Fructus Jujubae.
In order to obtain preferable technique effect further, a kind of pharmaceutical preparation treating anxiety neurosis, also include Rhizoma Cyperi 10-20 part, Rhizoma Zingiberis 3-12 part.
In order to obtain preferable technique effect further, a kind of pharmaceutical preparation treating anxiety neurosis, above each composition is according to weight Ratio is: 15 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 15 parts, Radix Bupleuri 20 parts, 12 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 15 parts, Bulbus Lilii 12 parts, Os Draconis 10 parts, 15 parts of Poria, the Rhizoma Pinelliae 10 parts, Radix Polygalae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Salviae Miltiorrhizae 12 parts, Concha Margaritifera 25 parts, floating Semen Tritici aestivi 30 parts, 6 pieces of Fructus Jujubae.
In order to obtain preferable technique effect further, a kind of pharmaceutical preparation treating anxiety neurosis, above each composition is according to weight Ratio is: 10 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Radix Bupleuri 12 parts, 6 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 10 parts, Bulbus Lilii 10 parts, Os Draconis 6 Part, 10 parts of Poria, the Rhizoma Pinelliae 6 parts, Radix Polygalae 10 parts, Caulis Polygoni Multiflori 10 parts, Radix Salviae Miltiorrhizae 10 parts, Concha Margaritifera 20 parts, Fructus Tritici Levis 20 parts, 3 pieces of Fructus Jujubae, Rhizoma Cyperi 10 parts, Rhizoma Zingiberis 3 parts.
In order to obtain preferable technique effect further, a kind of pharmaceutical preparation treating anxiety neurosis, above each composition is according to weight Ratio is: 20 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 20 parts, Radix Bupleuri 25 parts, 15 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 18 parts, Bulbus Lilii 15 parts, Os Draconis 15 parts, 20 parts of Poria, the Rhizoma Pinelliae 12 parts, Radix Polygalae 15 parts, Caulis Polygoni Multiflori 15 parts, Radix Salviae Miltiorrhizae 20 parts, Concha Margaritifera 30 parts, floating Semen Tritici aestivi 40 parts, 8 pieces of Fructus Jujubae, Rhizoma Cyperi 20 parts, Rhizoma Zingiberis 12 parts.
A kind of pharmaceutical preparation treating anxiety neurosis, described pharmaceutical preparation application in treatment anxiety neurosis medicine or health product.
A kind of pharmaceutical preparation treating anxiety neurosis, described pharmaceutical preparation is prepared as granule, powder, capsule, pill, sheet Agent and the most acceptable dosage form.
The moulding process that medicine of the present invention prepares different dosage form only used is different with adjuvant, and effective ingredient is the same, controls Therapeutic effect is the most identical or approximates.The adjuvant of granule can be to enter in multitudinous Icing Sugar, Carboxymethyl cellulose sodium, dextrin and correctives etc. Row selects；Powder can select from starch, kaolin, calcium phosphate, precipitated calcium carbonate etc.；The adjuvant of capsule can be from dioxy SiClx, sucrose, HPC, microcrystalline Cellulose, pregelatinized Starch, lactose, Icing Sugar, carboxymethylstach sodium, carmethose, Hypromellose etc. select；The adjuvant of pill can select from starch, microcrystalline Cellulose, pregelatinized Starch etc. Select；The adjuvant of tablet can be from starch, dextrin, microcrystalline Cellulose, pregelatinized Starch, magnesium stearate, lactose, Icing Sugar, carboxylic First Starch Sodium etc. select.
The pharmacological action of Chinese medicine used in the present invention:
Radix Rehmanniae Preparata, nourishing YIN and benefiting blood, vital essence replenishing and marrow benifiting；Radix Angelicae Sinensis, sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore can manage it again Blood, invigorating middle warmer has, has benefit, for the key medicine in blood in row.Radix Angelicae Sinensis sweet in the mouth and weigh, therefore specially can enrich blood, its gas is light and pungent, therefore Again can promoting the circulation of blood, invigorating middle warmer has, has benefit in row, for the key medicine in blood, thus, it can be enriched blood, and can invigorate blood circulation again, both can lead to Warp, again can be active.Radix Bupleuri, bitter flat, Gui Jing, enters liver, gallbladder meridian.Function: deliver, bring down a fever, soothing the liver, resolving depression, yang invigorating. Cure mainly: cat fever, alternate attack of chill and fever, malaria, side of body distending pain, menoxenia.Radix Glycyrrhizae, invigorating the spleen and replenishing QI, relieving spasm to stop pain, only eliminates the phlegm Cough, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.Semen Ziziphi Spinosae, have nourishing the liver, calm the nerves, effect of arresting sweating, and body void, night sweat etc. can be treated, Can be used for treating the symptoms such as insomnia forgetfulness, deficiency of YIN-blood, severe palpitation.Bulbus Lilii, detoxify, manage spleen stomach invigorating, dampness removing removing food stagnancy, The effect such as mind tranquilizing and the heart calming, blood circulation promoting, Os Draconis, tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, stop blooding astringing intestine to stop diarrhea, promoting tissue regeneration and ulcer healing.Fu Siberian cocklebur, harnesses the river swollen, and diuresis feels at ease to repose, antiinflammatory antitumor, treats cough with copious phlegm, sore waist and aching in the waist and the back, the Rhizoma Pinelliae, dampness Expectorant, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Radix Polygalae, Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, resolving depression.Caulis Polygoni Multiflori, tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral. Radix Salviae Miltiorrhizae, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind, removing heat from blood is subsided a swelling.Concha Margaritifera, arresting convulsion of calming the nerves, suppressing the hyperactive liver and subsiding YANG, clearing away heat to improve acuity of vision, hemostasis Dampness.Fructus Tritici Levis, hidroschesis, relieving restlessness of bringing down a fever, Fructus Jujubae, invigorating spleen and reinforcing stomach, benefiting qi and nourishing blood, nourishing blood to tranquillize the mind, relaxes the property of medicine.Fragrant Attached, dispersing the stagnated live-QI to relieve the stagnation of QI, menstruction regulating and pain relieving, to regulate the flow of vital energy in tune, Rhizoma Zingiberis, warming spleen and stomach for dispelling cold, recuperating depleted YANG promotes blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.
Semen Ziziphi Spinosae in we, Caulis Polygoni Multiflori, Radix Polygalae, Os Draconis, Radix Salviae Miltiorrhizae, Bulbus Lilii, the effect of Concha Margaritifera row mind tranquilizing and the heart calming, Poria, The Rhizoma Pinelliae, Radix Polygalae reaches the merit that damp eliminating is reduced phlegm, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Fructus Jujubae energy replenishing YIN and blood, Radix Bupleuri, Radix Paeoniae Alba energy dispersing the stagnated live-QI to relieve the stagnation of QI.This There is the treatment focused on this disease irritability primary symptom side, takes into account the administration features of the pathogenesis such as deficiency of YIN-blood, the stagnation of QI, stagnation of phlegm simultaneously. Depression is effective, have no side effect in treatment, easy to utilize.
Detailed description of the invention
It is obvious to a person skilled in the art that the details of the embodiment of the present invention, and without departing substantially from the spirit of the present invention or base In the case of eigen, it is possible to realize the present invention in other specific forms.Embodiment all should be regarded as exemplary, and It is nonrestrictive, it is intended that all changes fallen in the implication of equivalency and scope of claim are included at this In bright.
Embodiment 1: a kind of pharmaceutical preparation treating anxiety neurosis, each composition according to weight ratio is:
15 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 15 parts, Radix Bupleuri 20 parts, 12 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 15 parts, Bulbus Lilii 12 parts, Os Draconis 10 Part, 15 parts of Poria, the Rhizoma Pinelliae 10 parts, Radix Polygalae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Salviae Miltiorrhizae 12 parts, Concha Margaritifera 25 parts is floating little 30 parts of wheat, 6 pieces of Fructus Jujubae.
Above pharmaceutical preparation is prepared as capsule, and preparation method is as follows:
(1) by above-mentioned weight ratio weighting raw materials boiling twice, add 8 times amount water every time, decoct 1 hour for the 1st time, the Secondary decocts 40 minutes, merging filtrate, after filtration, is dried to fine powder, crosses 100 mesh sieves；(2) by celphere (with sugar Divide and the granule of the 30-40 mesh made by starch mixing), it is placed in coating granulator；(3) with pregelatinized Starch ethanol it is Wet adhesive, adds the granule-starch solids dispersion of 80 mesh with certain speed so that it is be formed uniformly granule；(4) It is dried, screens granule, obtain capsule.
Embodiment 2: a kind of pharmaceutical preparation treating anxiety neurosis, each composition according to weight ratio is:
10 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Radix Bupleuri 12 parts, 6 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 10 parts, Bulbus Lilii 10 parts, Os Draconis 6 parts, 10 parts of Poria, the Rhizoma Pinelliae 6 parts, Radix Polygalae 10 parts, Caulis Polygoni Multiflori 10 parts, Radix Salviae Miltiorrhizae 10 parts, Concha Margaritifera 20 parts, Fructus Tritici Levis 20 Part, 3 pieces of Fructus Jujubae, Rhizoma Cyperi 10 parts, Rhizoma Zingiberis 3 parts.
Above pharmaceutical preparation is prepared as pill, and preparation method is as follows:
(1) by above-mentioned weight ratio weighting raw materials boiling twice, add 8 times amount water every time, decoct 1 hour for the 1st time, the Secondary decocts 40 minutes, merging filtrate, after filtration, is dried to fine powder, crosses 100 mesh sieves；(2) by celphere (with sugar Divide and the granule of the 30-40 mesh made by starch mixing), it is placed in coating granulator；(3) with pregelatinized Starch ethanol it is Wet adhesive, adds the granule-starch solids dispersion of 100 mesh with certain speed so that it is be uniformly adhered in blank pill Wicking surface；(4) it is dried, screens 20-40 mesh sieve piller, to obtain final product.
Embodiment 3: a kind of pharmaceutical preparation treating anxiety neurosis, each composition according to weight ratio is:
20 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 20 parts, Radix Bupleuri 25 parts, 15 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 18 parts, Bulbus Lilii 15 parts, Os Draconis 15 Part, 20 parts of Poria, the Rhizoma Pinelliae 12 parts, Radix Polygalae 15 parts, Caulis Polygoni Multiflori 15 parts, Radix Salviae Miltiorrhizae 20 parts, Concha Margaritifera 30 parts is floating little 40 parts of wheat, 8 pieces of Fructus Jujubae, Rhizoma Cyperi 20 parts, Rhizoma Zingiberis 12 parts.
Above pharmaceutical preparation is prepared as tablet, and preparation method is as follows:
(1) Chinese medicine taking above amount decocts according to the method in embodiment 1, decocts rear medicinal liquid and concentrates, is concentrated into Finite concentration (proportion is about 1:1)；(2) 1.1 times of ethanol put of cold rear addition, fully mix, stand overnight so that it is Precipitation, takes its supernatant (filtering if desired) next day, and precipitate is cleaned with a small amount of 52% ethanol, and washing liquid merges with filtrate, subtracts Push back receipts ethanol after, to be concentrated to finite concentration time add a certain amount of water；(3) mixing stands certain time, makes precipitation complete, Rate mistake, filtrate low-temperature evaporation to paste, powdered extract powder adds suitable dextrin, pregelatinized Starch, magnesium stearate, Adjuvant；(4), after mixing, add and be pressed into the most whole to satisfactory granularity, carry out tabletting, obtain tablet.
Embodiment 4: a kind of pharmaceutical preparation treating anxiety neurosis, each composition according to weight ratio is:
18 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 18 parts, Radix Bupleuri 22 parts, 13 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 15 parts, Bulbus Lilii 12 parts, Os Draconis 12 Part, 18 parts of Poria, the Rhizoma Pinelliae 10 parts, Radix Polygalae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Salviae Miltiorrhizae 18 parts, Concha Margaritifera 26 parts is floating little 50 parts of wheat, 9 pieces of Fructus Jujubae, Rhizoma Cyperi 18 parts, Rhizoma Zingiberis 10 parts.
Above pharmaceutical preparation is prepared as powder, and preparation method is as follows:
(1) Chinese medicine taking above amount conventionally decocts, and decoct rear medicinal liquid carrying out being concentrated into proportion is 1:1.2's Concentration；(2) 1.5 times of ethanol put of cold rear addition, fully mix, stand overnight so that it is precipitation, take its supernatant next day, Precipitate is cleaned with a small amount of 50% ethanol, and washing liquid merges with filtrate, after decompression recycling ethanol, to be concentrated to finite concentration time shift Put cold place and stand certain time, make precipitation complete, rate mistake；(3) filtrate low-temperature evaporation is to paste, powdered extract powder Starch that middle addition is suitable and calcium phosphate adjuvant；(4), after mixing, cross 200 mesh sieves, obtain powder.
Embodiment 5 zoopery
5.1, animal modeling
Selecting Wistar rat 60, randomly select 10 and be only used as blank group, remaining is modeled, and rat is The healthy male Wistar rat of 130-150g, it is ensured that enter the rat weight of screening operation, kind, health status one Cause, select Wistar rat rather than other germline rat, because its pituitary-adrenal system function is flourishing, to stress Sensitivity, beneficially model are successfully, reproduced, and the environment carried out purchased rat one week adapts to, and mainly takes the raising side overturned round the clock Formula, makes rat the quietest, and night is excited, meets its person's character, it is simple to experiment is carried out.Then purchased rat is carried out conscientiously Careful screening, main obtain the near rat of split-phase by open field test screening and includes this experiment in, it is therefore an objective to eliminate individuality because of Element impact.
Uncertain empty bottle stimulus method sets up anxiety rats model: rat carried out the experiment of spacious field after 1 week laundering period, chose spacious 60 rats that field experiment score is close are tested, and randomly select 10 and are only used as blank group, and remaining is modeled, Often group 10, after the laundering period terminates, blank group is freely drunk water and is ingested, and remaining 5 groups are timed hello water and train 1 week, I.e. every morning 9:00～9:10 and 17:00～17:10 in afternoon to drinking water for animals 10min, remaining time remove water bottle not to Water.After timing hello the water phase terminates, other groups in addition to blank group start stress tests, give not within above-mentioned 2 time periods Definitiveness empty bottle, 1 day 1 time or 1 day 2 times, continues 2 weeks.
5.2, it is grouped and is administered
Be divided into 6 groups, in i.e. blank group, model group, Chinese medicine high dose group, Chinese medicine dosage group and Chinese medicine low dose group and Diazepam group.Start to give pharmaceutical intervention after two weeks, equal gastric infusion, every day 1 time, continuous use 7d, model group and Blank group all gives pure water 10ml kg-1·d-1；
Chinese medicine high dose group gives Chinese medicine 400mg kg of the present invention-1·d-1；
In Chinese medicine, dosage group gives Chinese medicine 200mg kg of the present invention-1·d-1；
Chinese medicine low dose group gives Chinese medicine 200mg kg of the present invention-1·d-1；
West is dissolved group group and is given diazepam suspension 1mg kg-1·d-1。
5.3, index observing
The most spacious field experiment test: experimental box perisporium bottom surface, spacious field is black, and operator holds at rat root of the tail 1/3, carefully Put into spacious center court, analyze the Behavioral change of system record animal 3min by camera system and Xmaze animal behavior.Often Rat test 3min, therebetween with 10% ethanol solution wiping experimental box removing animal traces, then is carried out after cleaning with dry cloth The test (covering abnormal smells from the patient, it is to avoid rat follows the traces motion of previous rat) of next rat.
5.3.2, EPM experiment test:
Before Elevated plus-maze test, every rat is put in a plastic casing (60cm × 60cm × 35cm), be allowed to free spy Be put in rapidly the central authorities of EPM after studying carefully 5min so that it is head just to a wherein open arms, carry out after release OE, OT, The mensuration of tetra-indexs of CE, CT.1. the number of times (OE) of open arms is entered into: enter into the number of times of arbitrary open arms, with greatly Four claws of Mus are as the criterion in all entering into arm, and the most any claw exits from this arm completely, and this entrance activity completes； 2. the time (OT) of open arms is entered into: unit (second)；3. the number of times (CE) of closure arm is entered into: enter arbitrary closing The number of times of arm, is as the criterion in all entering into arm with four claws of rat；4. the time (CT) of closure arm is entered into: unit (second). According to the most 4. calculating: 5. open arms enters number of times ratio (OE%), i.e. OE/ (OE+CE) × 100%, 6. opens Put arm time of staying ratio (OT%), i.e. OT/ (OT+CT) × 100%.Every rat test 5min, therebetween with 10% Animal traces are removed in ethanol solution wiping labyrinth, then clean with dry cloth.
5.4, experimental result
5.4.1 Mus spacious field experimental result
Each spacious field test result of organizing shows (being shown in Table 1), and the spacious field total path of model group rats is higher than blank group (P < 0.01)； The spacious field total path of each medicine group rat is less than model group rats (P < 0.01), compares no significant difference with blank group.
Table 1. is respectively organized rat spacious field experiment total path and is compared
Group Spacious field experiment total path (mm)
Blank group 5021.9±230.8
Model group 9873.4±491.6**
Diazepam group 6021.5±278.4#
Chinese medicine low dose group 7539.4±303.7#
Dosage group in Chinese medicine 6194.3±273.6##
Chinese medicine high dose group 5843.1±279.4#
Note:
* P < 0.05 compared with blank group is represented；* represents P < 0.01 compared with blank group；
# represents P < 0.01 compared with model group；## represents P < 0.01 compared with model group.
5.4.2 rat EPM experimental result
Each group rat EPM testing result shows (being shown in Table 2), and it is big that OE% and OT% of model group rats is below blank group Mus (P < 0.01)；The OE% of Chinese medicine each metering group and diazepam group rat is above model group (P < 0.05), and blank group nothing Significant difference；The OT% of BXD group and DZP group is above model group (P < 0.01), and blank group there was no significant difference.
OE% and the OT% value of rat respectively organized by table 2.
Group OE% OT%
Blank group 48.9±7.6 23.8±5.2
Model group 17.3±3.2* 6.7±1.2**
Diazepam group 31.7±6.8# 21.8±5.0##
Chinese medicine low dose group 28.6±5.5# 20.3±5.2#
Dosage group in Chinese medicine 24.6±4.0## 23.1±4.7#
Chinese medicine high dose group 21.8±3.5# 25.8±6.0##
Note: * represents P < 0.05 compared with blank group；* represents P < 0.01 compared with blank group；
# represents P < 0.01 compared with model group；## represents P < 0.01 compared with model group.
Embodiment 6: clinical experiment
6.1, physical data
In January, 2014, the maleest 44 examples, female 62 to anxiety patient 106 example of hospital outpatient during in December, 2015 Example；Age 18～69 years old, average 48 years old；The course of disease 2 months～12 months, average 5 months.
Tcm diagnosis standard: card belong to stagnated QI transforming into fire type: being irritable and irascible, fullness and distention in the chest and hypochondrium, bitter taste and dryness in the mouth, or headache, mesh Red, tinnitus, or noisy acid regurgitation, constipation, red tongue, yellow fur, wiry and frequent pulse.
Western medicine diagnose standard: all meet Chinese Spirit classification of diseases and the anxiety neurosis diagnostic criteria in diagnostic criteria (CCMD-3)； Clinical manifestation often has the lasting sky without clear and definite object or without immobilized substance to cry, or on tenterhooks, or psychentonia；Autonomous god Uneasy through symptom or mobility.Get rid of acute myocardial infarction, coronary heart disease, paroxysmal tachycardia, hypertension, thyroid merit Energy is hyperfunction, pheochromocytoma, climacteric syndrome, clinically use hormone medicine and psychoactive drug substance are given up and can be caused The anxiety symptom that autonomic nervous dysfunction occurs.
6.2, therapeutic scheme
Patient in this clinical trial is divided into 2 groups, respectively experimental group and matched group, is a course for the treatment of with 14 days.
Experimental group, for the pharmaceutical preparation+psychological counseling of prescription of the present invention, 53 examples；
Matched group, by diazepam in treating+psychological counseling, 53 examples.
6.3, criterion of therapeutical effect
Recovery from illness: anxiety symptom is alleviated, Manifest Anxiety Scale (SAS) scoring recovers normal；
Effective: anxiety symptom is alleviated substantially, SAS scoring declines 2 grades earlier above, but does not recovers normal；
Effective: anxiety symptom makes moderate progress, SAS scoring declines 1 grade earlier above, but does not recovers normal；
Invalid: anxiety symptom is without improving, and SAS scoring declines inconspicuous, or has risen.
Total effective=recovery from illness+effective+effectively.
6.4, therapeutic outcome
The results are shown in Table 3, through statistical analysis, two groups compare, and the obvious effective rate for the treatment of group is higher than matched group (table 3), tool There is significant difference (P < 0.05).Obvious effective rate=(recovery from illness+effective+effectively)/total case load.
The therapeutic outcome of 3 liang of table group medicine
Group Recovery from illness Effective Effectively Invalid Obvious effective rate
Matched group (53 example) 6 27 12 8 84.9%
Experimental group (53 example) 8 34 7 4 92.5%
6.5 model case
Case 1: Ma, female, 21 years old, university students, examines on May 5th, 2014.Thorough because being close to the examination appendix Insomnia at night, nervous, it is impossible to feel at ease to carry out daily studying and living, also had before inquiring represents to examination just anxiety in period Time, but this year is more because of course, and study at ordinary times is not, therefore has influence on living and studying, and health is all normal on inspection, Get rid of acute myocardial infarction, coronary heart disease, paroxysmal tachycardia, hypertension, hyperthyroidism, pheochromocytoma, Climacteric syndrome, clinically use hormone medicine and psychoactive drug substance are given up and autonomic nervous dysfunction can be caused to occur Anxiety symptom.Therapeutic scheme is convincing by patient analysis of the tablet of formula in the present invention, additional shrink and the head of a family, after one month, Can sleep normally and live normally.Further consultation after 3 months, without relapse indications, recovery from illness.
Case 2: Zheng, man, 69 years old, Top Management, within 2014, December was examined on the 22nd.Old man oneself is solitary, educates A son is had in other places work and to get married.Time medical, main suit often has a sleepless night, and bad dream is always made a phone call to son, represent right daytime Life various worries, health is normal on inspection, get rid of acute myocardial infarction, coronary heart disease, paroxysmal tachycardia, Hypertension, hyperthyroidism, pheochromocytoma, climacteric syndrome, clinically use hormone medicine and spirit are lived Property Substance Withdrawal can cause the anxiety symptom that autonomic nervous dysfunction etc. causes.Therapeutic scheme is the soup in the present invention in prescription Agent, additional shrink and the head of a family dredge, and after 1 month, can sleep basic evening and bad dream reduces.Check after 2 months, Recover orthobiosis the most completely, further consultation after 3 months, without relapse indications, recovery from illness.

Claims (7)

1. the pharmaceutical preparation treating anxiety neurosis, it is characterised in that described pharmaceutical preparation includes according to weight fraction ratio: Radix Rehmanniae Preparata 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Bupleuri 12-25 part, Radix Glycyrrhizae 6-15 part, Semen Ziziphi Spinosae 10-18 part, Bulbus Lilii 10-15 Part, Os Draconis 6-15 part, Poria 10-20 part, Rhizoma Pinelliae 6-12 part, Radix Polygalae 10-15 part, Caulis Polygoni Multiflori 10-15 part, Radix Salviae Miltiorrhizae 10-20 part, Concha Margaritifera 20-30 part, Fructus Tritici Levis 20-50 part, 3-10 piece of Fructus Jujubae.
A kind of pharmaceutical preparation treating anxiety neurosis, it is characterised in that described pharmaceutical preparation is pressed According to weight fraction than also including Rhizoma Cyperi 10-20 part, Rhizoma Zingiberis 3-12 part.
A kind of pharmaceutical preparation treating anxiety neurosis, it is characterised in that described pharmaceutical preparation is pressed According to weight fraction ratio it is: 15 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 15 parts, Radix Bupleuri 20 parts, 12 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 15 parts, Bulbus Lilii 12 Part, Os Draconis 10 parts, 15 parts of Poria, the Rhizoma Pinelliae 10 parts, Radix Polygalae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Salviae Miltiorrhizae 12 parts, Concha Margaritifera 25 parts, Fructus Tritici Levis 30 parts, 6 pieces of Fructus Jujubae.
A kind of pharmaceutical preparation treating anxiety neurosis the most according to claim 1 or claim 2, it is characterised in that described medicine system Agent according to weight fraction ratio is: 10 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 10 parts, Radix Bupleuri 12 parts, 6 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 10 parts, hundred Close 10 parts, Os Draconis 6 parts, 10 parts of Poria, the Rhizoma Pinelliae 6 parts, Radix Polygalae 10 parts, Caulis Polygoni Multiflori 10 parts, Radix Salviae Miltiorrhizae 10 parts, Margarita Female 20 parts, Fructus Tritici Levis 20 parts, 3 pieces of Fructus Jujubae, Rhizoma Cyperi 10 parts, Rhizoma Zingiberis 3 parts.
A kind of pharmaceutical preparation treating anxiety neurosis the most according to claim 1 or claim 2, it is characterised in that described medicine system Agent according to weight fraction ratio is: 20 parts of Radix Rehmanniae Preparata, Radix Angelicae Sinensis 20 parts, Radix Bupleuri 25 parts, 15 parts of Radix Glycyrrhizae, Semen Ziziphi Spinosae 18 parts, hundred Close 15 parts, Os Draconis 15 parts, 20 parts of Poria, the Rhizoma Pinelliae 12 parts, Radix Polygalae 15 parts, Caulis Polygoni Multiflori 15 parts, Radix Salviae Miltiorrhizae 20 parts, precious Pearl oyster 30 parts, Fructus Tritici Levis 40 parts, 8 pieces of Fructus Jujubae, Rhizoma Cyperi 20 parts, Rhizoma Zingiberis 12 parts.
6. according to the pharmaceutical preparation treating anxiety neurosis a kind of described in claim 1 or 2, it is characterised in that described medicine system Agent application in preparation treatment anxiety neurosis medicine.
7., according to the pharmaceutical preparation treating anxiety neurosis a kind of described in claim 1-6, described pharmaceutical preparation is prepared as granule, Powder, capsule, pill, tablet and the most acceptable dosage form.
CN201610204219.2A 2016-04-04 2016-04-04 Medicine preparation for treating anxiety disorder and preparation method thereof Withdrawn CN105770537A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116139228A (en) * 2023-04-03 2023-05-23 佛山市高明区中医院 Preparation for nourishing heart, soothing nerves and aiding sleep and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
丁树栋等: "验方治疗急性焦虑发作138例疗效观察 ", 《中国民族民间医药杂志》 *
东红等: "佛手养心安神汤治疗神经衰弱症76例 ", 《中医研究》 *
迟延威: "中西医综合治疗焦虑性神经症 ", 《黑龙江医学》 *

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116139228A (en) * 2023-04-03 2023-05-23 佛山市高明区中医院 Preparation for nourishing heart, soothing nerves and aiding sleep and preparation method thereof

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