CN101543587A - Chinese herbal compound for treating multiple convulsion and pharmaceutical composition using same - Google Patents

Abstract

The invention relates to a Chinese herbal compound for treating multiple convulsion and a pharmaceutical composition using the same, in particular to a Chinese herbal compound which is prepared by utilizing natural plants and is used for treating the multiple convulsion. The multiple convulsion multiple convulsion mainly comprises Chinese medicinal herbs such as radix scutellariae, rhizoma coptidis, phellodendron, gardenia, liquorice, red date, bombyx batryticatus, scorpion, centipede, rhizoma gastrodiae and the like, wherein the radix scutellariae, the rhizoma coptidis, and the phellodendron account for 15 to 21 percent of the total weight of the compound respectively; the gardenia, the liquorice, the red date, the bombyx batryticatus and the gastrodiae account for 6 to 9 percent of the total weight of the compound respectively; the scorpion and the centipede account for 2.50 to 4.50 percent of the total weight of the compound respectively; and the Chinese medicinal herbs are subjected to respective or mixing extraction and are concentrated or crushed into powder, and are added with a pharmaceutically acceptable carrier to be suitable for medicament application of treating the multiple convulsion.

Description

In order to the treatment multiple pumping symptoms Chinese herb compound and use its pharmaceutical composition

Technical field

The present invention with relate to a kind of with the treatment multiple pumping symptoms Chinese herb compound and use its pharmaceutical composition.

Background technology

Multiple pumping symptoms is called " multiple pumping symptoms " or " twitch obscene words syndrome " in Chinese medical circles, i.e. the Gi1les de la tourette syndrome of western medicine, and Taiwan is called Tourette syndrome (Tourette ' s syndrome).This disease belongs to the category of traditional traditional Chinese medical science " infantile convulsion ", " clonic convulsion Zong ", " Jin Ti Rou Shun ", " convulsion wind ".The application's case is all states " multiple pumping symptoms " person, its intention accurate this.

The cause of disease of multiple pumping symptoms again, cranial nerve medical science scholars think that comprising that the physiological structure sexually transmitted disease (STD) becomes institute in the brains such as basal nuclei, brain cortex, nerve conduction material be unusual causes that also under a cloud is individual's gene problem.

The sign of multiple pumping symptoms is the cranial nerve dyskinesias mostly; Unusual psychology, emotion, personality and the cognitive change of spirit are also often arranged.Condition of illness is often intricate, cross occurrence.

The childhood period that the first outbreak of multiple pumping symptoms being everlasting, may reduce pupil's learning capacity.The sick child that patient's homework does well in is no doubt many, and due to illness feelings are disturbed and school achievement slip person is a lot; There is the state of an illness of a few patients when university, senior middle school not alleviate yet and be forced to suspend schooling.

The multiple pumping symptoms person of being in a bad way of all times, repeatly through failing to respond to any medical treatment, family members often have recourse to religion ceremony, clergy, take for be patient be possessed, bewitched or by under curse, and changed name, change the edema due to wind pathogen, pray to the gods and seek to ascertain by divination, waste many money and mental suffering.

Multiple pumping symptoms patient's symptom comprises:

1, multiple pumping symptoms patient's nervous symptoms, for insignificant single kind of symptom or several symptoms concurrent, common symptom as " nictation, wrinkle volume, sting lip, grinningly, the nose that contracts, shake the head, nod, get rid of head, rolling head, fast will point insert the nostril, shrug, cough repeatedly sound, the sound that hawks, have the hiccups, hands is trembled, foot is trembled, foot soft walk as desire to topple over, endure abdomen air-breathing, turn round abdomen.」

2, the emotion and the mental symptom of multiple pumping symptoms patient appearance, study according to neuroimaging, may basal nuclei and the connection of cortex of frontal lobe between down be to go wrong, cause insignificant single kind of symptom or several symptoms concurrent, as " show the whites of one's eyes, grimace, stuck out one's tongue, spit, spout water, roll, ram, knock on the table, feel sorrow for oneself, hurt sb.'s feelings, pound thing on the ground, sting clothes, hands touch the fast near again nose of article hear smell, obscene words, sound language disease (madly cry, boof, tweedle, quack, individual character, speech) " etc.

3, serious psychology, emotion, the mental status is as " rattiness, restless, answer back, abuse ".

4, the multiple pumping symptoms patient and if his disease is arranged, often make the state of an illness serious complicated more.For example merge obsession, infantile autism, melancholia, Wilson's disease (copper ion rising).Condition of illness such as restlessness, rhinitis, oral mucosa diabrosis, hallucination, dream trip, pollakiuria, bed-wetting, cervical spondylolisthesis displacement, injury oneself, antisocial behavior are also often arranged.

5, " sound language disease " (sounding twitch) is multiple convulsion disease group patient's special condition of illness.By the obscene words that send in patient's mouth, bark sound, tweedle, quack and Chinese, English individual character, speech etc.; All be that patient once learned or listened, call out by subconsciousness; Each or repetition continuously in two seconds when serious, insignificant sounding.But patient's the state of mind is not affected, and after the doctor asked his problem, the patient can answer at once, still continues to send the sound language after the answer.

Western medicine is admitted effectively to treat multiple pumping symptoms at present, and many countries set up multiple pumping symptoms association with exchange message, and assists patient and family members.For example in the U.S. multiple pumping symptoms association (http://www.tsa-usa.org/) of establishment in 1972, the Britain multiple pumping symptoms association (http://www.tsa.org.uk/) that set up in 1980, the Canadian state multiple pumping symptoms association (http://www.tourette.ca/) that set up in 1976, Taiwan multiple pumping symptoms association (http://www.ttfa.org.tw/) etc.

Medical modes such as the medicine of the traditional Chinese medical science or acupuncture are not seen the report that has significant effective to treat extensive multiple pumping symptoms patient yet.

In view of this, the inventor at aforementioned existing multiple pumping symptoms in, the problem that faced on the western medical treatment time, deeply inquire into inhibition and treatment that the Central Plains medicine characterizes multiple pumping symptoms simultaneously, and actively seek the road that solves, through the research and development of long-term endeavour, success finally develop a kind of in order to the treatment multiple pumping symptoms Chinese herb compound and use its pharmaceutical composition.

Summary of the invention

Technical problem underlying to be solved by this invention is, overcome the above-mentioned defective that prior art exists, and provide a kind of in order to the treatment multiple pumping symptoms Chinese herb compound and use its pharmaceutical composition, reach the purpose of slowing down or suppressing multiple pumping symptoms and treatment or inhibition multiple pumping symptoms.

The present invention in order to the Chinese herb compound of treatment multiple pumping symptoms is:

A kind of Chinese herb compound in order to the treatment multiple pumping symptoms is characterized in that, comprises that Chinese herbal medicine such as Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, Rhizoma Gastrodiae, stiff silkworm, scorpion and Scolopendra form; Wherein Radix Scutellariae, Rhizoma Coptidis and Cortex Phellodendri account for 15%～21% of compound recipe gross weight separately, and Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, stiff silkworm and Rhizoma Gastrodiae account for 6%～9% of compound recipe gross weight separately, account for 2.50%～4.50% of compound recipe gross weight separately as for scorpion and Scolopendra; Whereby, group constitutes a Chinese herb compound in order to the treatment multiple pumping symptoms.

Aforesaid Chinese herb compound, wherein Radix Scutellariae 5 money～10 money, Rhizoma Coptidis 5 money～10 money, Cortex Phellodendri 5 money～10 money, Fructus Gardeniae 2 money～4 money, Radix Glycyrrhizae 2 money～3 money, Fructus Jujubae 2 money～10 money, stiff silkworm 2 money～3 money, scorpion 1 money～3 money, Scolopendra 1 money～3 money and Rhizoma Gastrodiae 2 money～3 money in order to the treatment multiple pumping symptoms.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3 money, Cortex Magnoliae Officinalis 4 money, Poria 4 money, stir-baked FRUCTUS PERILLAE 4 money, Fructus Tritici Levis 10 money, Arillus Longan 5 money, be used for co-therapy multiple pumping symptoms patient and be in a bad mood, cognitive, mentally disturbed, can promote the balance of brain neuroblastoma Transmitter serotonin.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add Os Draconis 5 money, Concha Ostreae 5 money, Gypsum Fibrosum 10 money, be used for co-therapy multiple pumping symptoms patient and loud and sonorous emotion, autotomy, the person of hurting sb.'s feelings arranged, rapidly heat-clearing and toxic substances removing, the peace soul relieving convulsion.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add Olibanum, Myrrha, Semen Persicae, Flos Carthami, Pheretima, Radix Salviae Miltiorrhizae, for the treatment person that has the syndrome of blood stasis.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, Arisaema Cum Bile, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Raphani, Fructus Perillae, Semen Sinapis Albae, for treatment abundant expectoration person.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add Radix Paeoniae, for treatment abdominal part anxiety, neck stiffness, muscle contraction person.

Aforesaid Chinese herb compound in order to the treatment multiple pumping symptoms, wherein compound recipe can add the Radix Angelicae Dahuricae, Flos Magnoliae, Fructus Xanthii, for treatment rhinitis or twang symptom is arranged.

The present invention in order to the pharmaceutical composition of the Chinese herb compound of treatment multiple pumping symptoms is:

A kind of pharmaceutical composition of Chinese herb compound in order to the treatment multiple pumping symptoms, it is characterized in that, comprise that its amount is for can effectively treating, slow down or suppress multiple pumping symptoms according to the Chinese herb compound and the pharmaceutically acceptable carrier that define in the claim 1; Whereby, group constitutes a pharmaceutical composition in order to the treatment multiple pumping symptoms.

Whereby, by representing of aforementioned techniques means, can use Chinese herbal medicine of the present invention respectively or hybrid extraction concentrate or pulverize into powder after form, and in adding pharmaceutically acceptable carrier, to be applicable to the medicinal usage of treatment multiple pumping symptoms, further improve multiple pumping symptoms patient's quality of life.

The specific embodiment

The present invention is a kind of Chinese herb compound that utilizes natural herbal plant composition in order to the treatment multiple pumping symptoms, should include Chinese herbal medicine such as Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, Rhizoma Gastrodiae, stiff silkworm, scorpion and Scolopendra in order to the Chinese herb compound of treatment multiple pumping symptoms and form:

Wherein Radix Scutellariae, Rhizoma Coptidis and Cortex Phellodendri account for 15%～21% of compound recipe gross weight separately, and Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, stiff silkworm and Rhizoma Gastrodiae account for 6%～9% of compound recipe gross weight separately, account for 2.50%～4.50% of compound recipe gross weight separately as for scorpion and Scolopendra;

The when per 1000 g preferable weight of the preferable weight of each composition of compound recipe of the present invention is:

	Radix Scutellariae	Rhizoma Coptidis	Cortex Phellodendri	Fructus Gardeniae	Radix Glycyrrhizae	Fructus Jujubae	The stiff silkworm	Scorpion	Scolopendra	Rhizoma Gastrodiae
											The weight of each composition of 1000g (g)	185.2	185.2	185.2	74.1	74.1	74.1	74.1	37.0	37.0	74.0

The drug effect of each composition of compound recipe of the present invention again, effect are recited as according to the classic of TCM " Bencao Beiyao "; Wherein:

Radix Scutellariae is burnt excess-fire in rushing down, and it is damp and hot to remove spleen man; Control blood hold one's breath contrary, ulcer sores; Sun is moved back in yin nourishing, mends bladder water; Purte the white, profit is gas in the heart, and the wind heat of controlling the part of the body cavity above the diaphragm housing the heart and lungs is damp and hot.

Rhizoma Coptidis is then for going into heart pathogenic fire purging; Town's liver removing heat from blood, dampness dissipating depression of QI, the relieving restlessness of quenching one's thirst; The liver benefiting gallbladder, thick the intestines and stomach, the diabetes with polydipsia as the prominent symptom stasis of blood is ended night sweat; Control fetal toxicosis.The arresting convulsion that makes eye bright, the hidroschesis detoxifcation.

Cortex Phellodendri is for rushing down bladder fire mutually again, and the kidney invigorating extreme misery is sufficient, and hard kidney is moisturized, and removes damp and clearing heat; Control conjunctival congestion tinnitus; All skin ulcer sufferings, head sore; Aphtha.

And Fructus Gardeniae is the pathogenic heat of removing pathogen in the heart lung, and the flexing that makes is descending, and from urinating, and the stagnated fire of three warmers is to separate; Control vexed regretful Nang sleeplessness; Thirsty conjunctival congestion.

Radix Glycyrrhizae is then made a living flat with gas, tonifying the spleen and stomach deficiency, and eliminating heart-fire; Go into cool agent and then rush down pathogenic heat, go into high dose of then slow healthy energy; The all medicines of energy consonance, what make is out of question, the granulation promoting pain relieving, current 12 warps are separated hundred poison of drug.

For growing spleen soil, the profit cardiopulmonary transfer battalion to defend as for Fructus Jujubae, slow cloudy blood; Born fluid, improving healthy complexion, logical nine orifices helps 12 warps and hundred medicines.

Rhizoma Gastrodiae then is the QI invigorating reinforcing YIN-essence in addition, promoting blood circulation, and strong biceps is dredged expectorant gas; Control all dizziness due to wind pathogen and fall, head revolves pupil, and language is unsuccessful, rheumatoid arthritis stubborn, pediatric epilepsy scared.

And the stiff silkworm is an expelling wind and eliminating phlegm, and eliminating stagnation is passed through; Control apoplectic aphasia, wind syndrome of head toothache, children's's heart malnutrition in infant.

Scorpion then has all dizziness due to wind pathogen to fall again, and infantile convulsion is jerked and pulled, deviation of the eye and mouth.

And Scolopendra does good away and can loose, and controls the infantum tetanus locked jaw; Infantile convulsion scrofula drop.

Moreover be monarch with Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri in the compound recipe of the present invention, being used for rushing down the pyretic toxicity of the part of the body cavity above the diaphragm housing the heart and lungs, Jiao, the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, sun is moved back in yin nourishing, the arresting convulsion detoxifcation.Be minister with the Fructus Gardeniae in addition, but the pathogenic heat of removing pathogen in the heart lung, the stagnated fire of separating three warmers.And with Radix Glycyrrhizae, Fructus Jujubae, Rhizoma Gastrodiae is assistant, in order to all medicines of coordinating, and current 12 warps; Transfer battalion to defend, slow cloudy blood; Promoting blood circulation, strong biceps is dredged mental disorder.Then for making, it can expelling wind and eliminating phlegm as for stiff silkworm, scorpion, Scolopendra, and eliminating stagnation is passed through; All dizziness due to wind pathogen fall, and infantile convulsion is jerked and pulled, deviation of the eye and mouth; The infantum tetanus locked jaw, infantile convulsion scrofula drop.

Simultaneously all medicine energy heat-clearing and toxic substances removing, suppressing the hyperactive liver to arrest the wind syndrome, the high response of the cranial nerve conduction function of co-therapy multiple pumping symptoms, [tics] twitched in caused motion, the sounding that also can effectively treat multiple pumping symptoms is twitched, the emotion cognitive disorder, and then group constitutes a Chinese herb compound in order to the treatment multiple pumping symptoms.

Chinese herb compound of the present invention can typically extract, concentration technique is mixed into medicated powder at compound recipe crude drug [crude drug] or after distinctly composition crude drug [crude drug] extracts, concentrates and gets, this medicated powder also can directly be pulverized powdered and got by crude drug [crude drug], and comprising its amount is effectively to treat, slow down or to suppress the Chinese herb compound of multiple pumping symptoms, and pharmaceutically acceptable carrier.

Practice of the present invention, be consider the patient body weight too much the whether dysplasia of not enough, height, green around the gills or ruddy, speaking volume is big or small, hard stool or soft, and considers the multiple convulsion disease order of severity, just determines the dosage of administration.

Its administration is based on crude drug [crude drug] decoct.Medicated powder is auxilliary.And the crude drug decoction method considers that the light clear row of Chinese medicine goes into part of the body cavity above the diaphragm housing the heart and lungs pharmacology, and defers to classic of TCM record, only decocts once, divides clothes two or three times, and ante cibum or after meal, decoction being taken warmly or be taken cold all can.And when the multiple convulsion symptom has been slowed down or almost lose, therapeutic dose is reduced gradually; The medicine card changes one docile and obedient two days or three days into, or changes the powder of taking medicine into.

Moreover according to the adjustment reference of indivedual different symptoms, with treatment brain neuroblastoma pathological changes disease like convulsion, twitch, tremble or disease such as dizzy is an example, often adopt Rhizoma Gastrodiae, make Scorpio, make golden Scolopendra, white stiff silkworm, Radix Curcumae, Rhizoma Corydalis, Ramulus Uncariae Cum Uncis, Rhizoma Acori Graminei, Radix Polygalae etc.And the treatment person that has the syndrome of blood stasis can add Olibanum, Myrrha, Semen Persicae, Flos Carthami, Pheretima, Radix Salviae Miltiorrhizae.The abundant expectoration person can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, Arisaema Cum Bile, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Raphani, Fructus Perillae, Semen Sinapis Albae again.Abdominal part anxiety, neck stiffness, muscle contraction person can add Radix Paeoniae in addition.As for rhinitis or twang symptom are arranged, can add the Radix Angelicae Dahuricae, Flos Magnoliae, Fructus Xanthii.And nerve is when being in excited state for a long time, then effectively after the control, adds the medicine that promotes gastrointestinal absorption function, QI invigorating blood deficiency in administration with its syndrome.On daily life diet compatibility and incompatibility of drugs, suggestion sufferer diet should increase natural protein, for example fresh egg, meat, fish, dish etc. in addition.And avoid greasy, stimulation, irritability food, for example avoid wine, coffee, tea, cola, Fructus Piperis, Fructus Capsici, spicy pot etc.; The also hot stewed benefit food of inedibility.And the suggestion sufferer is done the motion that can sweat under the sunlight more.

Embodiment 1

First visit on October 22 in 2004,13 years old, the man.Wear protective cover on the head, outbreak is violent, and the special messenger of Bureau of Education teaches.

Patient's morbidity in 8 years old, clothes Western medicine 5 years is not intermittently gone to school second grade special education class in the state.Can grab, hit mother, make mother's Multiple Wounds, but often must have mother in arms after the outbreak.Through magnetic shake radiography and EEG (electrocardiogram) examination, no abnormal.Once the secondary of being in hospital, the sound of shouting strangely during first visit is very big, frightened, fall down, madly cry, scold.About ten minutes mad cry fall down once, autolesionism.Spirit is in excited state.The waiting to see the doctor of first visit, examine, examine in about 40 minutes of the back neck medicine, take place altogether repeatedly madly to be, to cry and shout, to desire to hit wall and stop suddenly, jump up suddenly at patient's seat.Roll more than seven times in serious ground, tightly held each about 1～2 minute by its mother.After patient's autolesionism, the consciousness expression just as ordinary person chatting and laughing.Computer keyboard there is fear, has broken three keyboards in the family, repeatedly pound doctor's computer keyboard during first visit as important and influential persons.Once obey Western medicine and reach 18 every day.

Clothes Western medicine (1) Trihexyphendyl before going to a doctor, hcl, 2mg takes sooner or later, each 2.(2) Haloperidol, 5mg sooner or later takes each 2.(3) Bupropion, 150mg sooner or later takes each half.This patient once was in a bad way and the secondary of being in hospital, and shake radiography and EEG (electrocardiogram) examination of relevant inspection, the magnetic of brain all do not note abnormalities.

Take Chinese herbal medicine constituent of the present invention, it is mainly filled a prescription and is Radix Scutellariae five money～ten money, Rhizoma Coptidis five money～ten money, Cortex Phellodendri five money～ten money, Fructus Gardeniae two money～four money, Radix Glycyrrhizae two money～three money, Fructus Jujubae two money～ten money, stiff silkworm two money～three money, scorpion one money～three money, Scolopendra one money～three money and Rhizoma Gastrodiae two money～three money, boil medicine with the crude drug water-boiling method, the water that adds 4.5～6 bowls, decoct once, be divided into three parts, early before the noon supper or drink after meal and all can; Or be divided into twice, sooner or later all can ante cibum or drink after meal.

This patient starts to school from February 14th, 2005 and can normally give a lesson day, and on the same month in the same year 23 rose and needn't embrace or haul mother.Rise and take off head hoop April 25 the same year, and head is rolling no longer.It is many that this patient obeys Western medicine dosage, is difficult to give up.Once withdrew and obeyed Western medicine again again behind the Western medicine in 21 days.And clothes Western medicine 451 talentes that successively decrease give up.In JIUYUE, 2006.The state of an illness alleviates, and enters professorship's reading.Up in November, 2006, took traditional Chinese medicine altogether 703 days.Follow the trail of in July, 2007, and drug withdrawal is 9 months, and slight twitch is still arranged, and achievement is the degree that goes up in the class.(see also the inventor and compiling " Chinese traditional treatment of funny face～Tourette syndrome of angel " P187 ~ 195, in January, 2006 distribution of book spring publishing house.)

Embodiment 2

December in 2004 first visit on the 8th, neural mental symptom.12 years old, the man.Outbreak in 9 years old, sick 3 years.Once took certain hospital's medicine a year and a half, another hospital's medicine two months stopped Western medicine 4 months.When this patient goes to a doctor, have shrug, rock fast about head, above the waist shake, two handss strut as wing fly shape, frequent nictation, irritability, neck sprain of muscle and tendon moving.

This patient takes Chinese herbal medicine constituent of the present invention, it is mainly filled a prescription and is Radix Scutellariae five money～ten money, Rhizoma Coptidis five money～ten money, Cortex Phellodendri five money～ten money, Fructus Gardeniae two money～four money, Radix Glycyrrhizae two money～three money, Fructus Jujubae two money～ten money, stiff silkworm two money～three money, scorpion one money～three money, Scolopendra one money～three money and Rhizoma Gastrodiae two money～three money, boil medicine with the crude drug water-boiling method, the water that adds 4.5～6 bowls, decoct once, be divided into three parts, early before the noon supper or drink after meal and all can; Or be divided into twice, sooner or later all can ante cibum or drink after meal.

Patient on October 28th, 2005, disease subtracts.Only have that right shoulder is alarmmed, shortly coughed, right neck is slightly turned round flesh, 324 days outpatient service phases, taken medicine 330 days.Follow the trail of in August, 2007, do not take medicine again, recovery from illness so far 1 year 9 months, achievement in being in the class on.(see also the inventor and compiling " Chinese traditional treatment of funny face～Tourette syndrome of angel " P160 ~ 161, in January, 2006 distribution of book spring publishing house.)

Embodiment 3

The patient is in first visit on January 17 in 2006, has to twitch and send ＂ factory bifurcation, " the different sound of [1 time/3 ~ 20 seconds] and give great volume the phenomenon that hands and foot can twitch and have foot to takeoff.24 years old, the man.Outbreak in 7 years old, clothes Western medicine 17 years.Promptly withdraw Western medicine after taking traditional Chinese medicine.

This patient takes Chinese herbal medicine constituent of the present invention, it is mainly filled a prescription and is Radix Scutellariae five money～ten money, Rhizoma Coptidis five money～ten money, Cortex Phellodendri five money～ten money, Fructus Gardeniae two money～four money, Radix Glycyrrhizae two money～three money, Fructus Jujubae two money～ten money, stiff silkworm two money～three money, scorpion one money～three money, Scolopendra one money～three money and Rhizoma Gastrodiae two money～three money, boil medicine with the crude drug water-boiling method, the water that adds 4.5～6 bowls, decoct once, be divided into three parts, early before the noon supper or drink after meal and all can; Or be divided into twice, sooner or later all can ante cibum or drink after meal.

In still treating on August 27th, 2007, disease subtracts, and only sends very slight ＂, and " sound, trick is not twitched.625 days outpatient service phases, took traditional Chinese medicine 385 days.

Embodiment 4

Chinese herb compound of the present invention also can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3 money, Cortex Magnoliae Officinalis 4 money, Poria 4 money, stir-baked FRUCTUS PERILLAE 4 money, Fructus Tritici Levis 10 money, Arillus Longan 5 money.Its purpose be co-therapy multiple pumping symptoms patient and be in a bad mood, cognitive, mentally disturbed, can promote the balance of brain neuroblastoma Transmitter serotonin.

Embodiment 5

Chinese herb compound of the present invention can add Os Draconis 5 money, Concha Ostreae 5 money, Gypsum Fibrosum 10 money in addition.Its purpose is co-therapy multiple pumping symptoms patient and loud and sonorous emotion, autotomy, the person of hurting sb.'s feelings arranged, rapidly heat-clearing and toxic substances removing, the peace soul is relieving convulsion.

Moreover the inventor is from August, 2004 to 2007 year by the end of February [according to the Master's thesis data of the inventor in 2004 grades of LiaoNing, China universities of TCM], the clinical experience at 2 years seven months, 524 multiple pumping symptoms patients of diagnosis and treatment once.This clinical statistics is got rid of has nervus centralis diseases such as chorea, hepatolenticular degeneration, epilepsy myoclonus, the cerebral tumor and other cone are to cause twitch person's [11 example] outward; Eliminating is with mentally disturbeds's [24 example] such as obvious obsession, infantile autism, melancholias; Eliminating is only seen to examine once and was difficult to regard as traditional Chinese medical science curative effect person [180 example] in 30 days with the less than that takes traditional Chinese medicine; Also get rid of non-with Chinese herb compound therapist of the present invention [7 example].Behind the deduction, the patient that this clinical research utilizes Chinese herb compound of the present invention treatment is totally 302 examples, male 264 people (87%) wherein, women 38 people (13%).Alleviate 68 examples (22.52%), produce effects 178 examples (accounting for 58.94%), effective 40 examples (accounting for 13.25%), invalid 16 examples (accounting for 5.30%) at last fully.Total effective rate is 94.70%[such as table 1].

The routine curative effect statistical table of table 1.302

	Alleviate fully	Produce effects	Effectively	Invalid	Add up to
						The example number	68	178	40	16	302
Cure rate	22.52％	58.94％	13.25％	5.30％

Be 302 routine patients to be split up into take Chinese herb compound of the present invention [calling Chinese drug-treated group in the following text] merely and take Chinese herb compound of the present invention and take Western medicine [calling Chinese medicine and western medicine and clothes group in the following text] in actual clinical treatment, do efficacy analysis respectively.Wherein Chinese drug-treated group [as table 2], totally 257 people.Alleviate 59 people (22.96%), produce effects 157 people (61.09%), effective 29 people (11.28%), invalid 12 people (4.67%) fully, total effective rate is 95.33%.And Chinese medicine and western medicine and clothes group [as table 3], totally 45 people.Alleviate 9 people (20.00%), produce effects 21 people (46.67%), effective 11 people (24.44%), invalid 4 people (8.89%) fully, total effective rate is 91.11%.

The curative effect statistics of the routine treatment by Chinese herbs group of table 2.257

	Alleviate fully	Produce effects	Effectively	Invalid	Add up to
						The example number	59	157	29	12	257
Cure rate	22.96％	61.09％	11.28％	4.67％	100.00％

The curative effect statistics of routine Chinese medicine and western medicine of table 3.45 and clothes group

	Alleviate fully	Produce effects	Effectively	Invalid	Add up to
						The example number	9	21	11	4	45
Cure rate	20.00％	46.67％	24.44％	8.89％	100.00％

Be to analyze between two groups with chi-square test [The Chi-square Test], and obviously difference of nothing (P〉0.05), illustrate that Chinese drug-treated group is consistent with Chinese medicine and western medicine and clothes group curative effect.Symptom minimizing ratio after the treatment of curative effect test and appraisal with patient, before the treatment calculates.Its computational methods are, each patient is at the twitch quantity of " before the treatment ", frequency, intensity, complexity, life annoyance level etc., and its state of an illness numerical value of attending doctor's comprehensive assessment all is made as 1 (100%); " treatment back " also comprehensive assessment its twitch quantity, frequency, intensity, complexity, life annoyance level etc., its state of an illness numerical value has reduced how much percentage ratio (%).

Because medical circles generally acknowledge that multiple pumping symptoms recurs symptom easily and changes symptom, the state of an illness is to alleviate or fully recover must treat tracking for a long time and confirm, " patient can the oneself judge the state of an illness and determine its treatment number of days of taking medicine " be adopted in clinical research of the present invention, there is no and forces its medication treatment.It is initial day that the present invention studies the first visit day that statistics adopts each patient, and the statistics deadline is each one last outpatient service day; But still the last statistics deadline of continuous therapist is on February 28th, 2007.

Wherein the curative effect test and appraisal are divided into level Four:

Alleviate fully: transference cure, subtract Fen to Shuai ≧ 75%;

Produce effects: big disappearance of symptom, subtract Fen to Shuai ≧ 50%;

Effectively: sx, subtract Fen to Shuai ≧ 30%;

Invalid: the symptom no change subtracts branch rate＜30%.

Total effective rate: (alleviating number+produce effects number+significant figure fully) * 100%

Its comprehensive curative effect statistics and analysis are as table 4

The pure Chinese drug-treated group of table 4. and and obey X between the Chinese medicine and western medicine group ²Check

Group	Alleviate fully	Produce effects	Effectively	Invalid	Add up to	X 2	P
								Chinese drug-treated group	59(22.96 ％)	157(61.0 9％)	29(11.28 ％)	12(4.67 ％)	257	6.7370 23	>0.05
Chinese medicine and Western medicine group	9(20.00％ )	21(46.67 ％)	11(24.4％ )	4(8.89％ )	45
								Add up to	68(22.52 ％)	178(58.9 4％)	40(13.25 ％)	16(5.29 ％)	302

And the present invention further analyzes the curative effect of the different courses of disease, with the course of disease be divided into the morbidity 1 year with interior, 1～5 year, 5～10 years, more than 10 years four sections analyze (seeing Table 5), find that the complete remission rate in 1 year is higher, reach 31.71%, but X 2 test does not have significant difference (P〉0.05), may with the rare pass of sample size.Row statistics again should be further increased behind the sample.

The efficacy analysis of the different courses of disease of table 5.

The course of disease	Alleviate fully	Produce effects	Effectively	Invalid	Add up to	X2	P
								In 1 year	26(31.71％)	46(56.09％)	7(8.54％)	3(3.65％ )	82	15.1349 8	>0.05
＜5 years	25(18.66％)	88(65.67％)	14(10.45 ％)	7(5.22％ )	134
								＜10 years	8(18.18％)	22(50.00％)	11(25.00 ％)	3(6.82％ )	44
10 years	8(19.05％)	23(54.76％)	8(19.05％ )	3(7.14％ )	42
								Add up to	69(22.18％)	177(59.27％ )	40(13.25 ％)	16(5.30 ％)	302

And further at the efficacy analysis of different course, will be divided into 1 year the course of treatment with interior, 1～2 year, analyze (seeing Table 6) more than 2 years.The curative effect of different course is different (P＜0.05) obviously, more than 2 years the course of treatment best (produce effects above account for 100.00%), secondly is the curative effect (produce effects above account for 92.36%) of 1-2, illustrates that the course of treatment long-acting more fruit is good more.In alleviating fully, be best, illustrate in treatment clinical course with 2 years to be that a course of treatment is comparatively suitable with 1-2 course of treatment.But the total effective rate of each course of treatment does not have significant difference (seeing Table 7).

The curative effect statistics of table 6. different course

The course of treatment	Alleviate fully	Produce effects	Effectively	Invalid	Add up to	X2	P
								In 1 year	48(19.59％)	146(59.5 9％)	36(14.69 ％)	15(6.12 ％)	245	15.187 71	<0.05
1-2	20(42.55％)	22(46.81 ％)	4(8.51％)	1(2.13％ )	47
								More than the 2-	2(20.00％)	8(80.00％	0(0.00％)	0(0.00％ )	10

		)
								Add up to	70(23.18％)	176(58.2 8％)	40(13.25 )	16(5.29 ％)	302

The statistical analysis of table 7. total effective rate in each course of treatment

The course of treatment	In 1 year	1-2	2-3	Add up to	X2	P
							Effectively	230	46	10	286	1.958267	>0.05
Invalid	15	1	0	16
							Add up to	245	47	10	302

And at the efficacy analysis of all ages and classes, 302 routine patients are carried out fractional analysis (seeing Table 8) by preschool (0～7 years old), teenager (8～18 years old) and adult (more than 19 years old), curative effect between each age group does not have significant difference (P〉0.05), illustrates that treatment by Chinese herbs adapts to the patient of all ages and classes section.

The curative effect statistics of table 8. age groups

Age	Alleviate fully	Produce effects	Effectively	Invalid	Add up to	X2	P
								0-7 year	12(24.00％ )	32(64.00 ％)	4(8.00％)	2(4.00％ )	50	2.31210 5	>0.05
8-18 year	50(22.32％ )	131(58.4 8％)	31(13.84 ％)	12(5.36 ％)	224
								More than 19 years old	6(21.43％)	15(53.57 ％)	5(17.86％ )	2(7.14％ )	28
Add up to	68(22.52％ )	178(58.9 4％)	40(13.24 ％)	16(5.30 ％)	302

The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did.

In sum, the present invention is on structural design, use practicality and cost benefit, it is required to meet industry development fully, and the structure that is disclosed also is to have unprecedented innovation structure, have novelty, creativeness, practicality, the regulation that meets relevant patent of invention important document is so mention application in accordance with the law.

Claims (9)

1, a kind of Chinese herb compound in order to the treatment multiple pumping symptoms is characterized in that, comprises that Chinese herbal medicine such as Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, Rhizoma Gastrodiae, stiff silkworm, scorpion and Scolopendra form;

Wherein Radix Scutellariae, Rhizoma Coptidis and Cortex Phellodendri account for 15%～21% of compound recipe gross weight separately, and Fructus Gardeniae, Radix Glycyrrhizae, Fructus Jujubae, stiff silkworm and Rhizoma Gastrodiae account for 6%～9% of compound recipe gross weight separately, account for 2.50%～4.50% of compound recipe gross weight separately as for scorpion and Scolopendra;

Whereby, group constitutes a Chinese herb compound in order to the treatment multiple pumping symptoms.

2, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 1 is characterized in that: described Radix Scutellariae 5 money～10 money, Rhizoma Coptidis 5 money～10 money, Cortex Phellodendri 5 money～10 money, Fructus Gardeniae 2 money～4 money, Radix Glycyrrhizae 2 money～3 money, Fructus Jujubae 2 money～10 money, stiff silkworm 2 money～3 money, scorpion 1 money～3 money, Scolopendra 1 money～3 money and Rhizoma Gastrodiae 2 money～3 money.

3, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 2, it is characterized in that: described compound recipe can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 3 money, Cortex Magnoliae Officinalis 4 money, Poria 4 money, stir-baked FRUCTUS PERILLAE 4 money, Fructus Tritici Levis 10 money, Arillus Longan 5 money, be used for co-therapy multiple pumping symptoms patient and be in a bad mood, cognitive, mentally disturbed, can promote the balance of brain neuroblastoma Transmitter serotonin.

4, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 2, it is characterized in that: described compound recipe can add Os Draconis 5 money, Concha Ostreae 5 money, Gypsum Fibrosum 10 money, be used for co-therapy multiple pumping symptoms patient and loud and sonorous emotion, autotomy, the person of hurting sb.'s feelings arranged, rapidly heat-clearing and toxic substances removing, the peace soul relieving convulsion.

5, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 1, it is characterized in that: described compound recipe can add Olibanum, Myrrha, Semen Persicae, Flos Carthami, Pheretima, Radix Salviae Miltiorrhizae, for the treatment person that has the syndrome of blood stasis.

6, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 1, it is characterized in that: described compound recipe can add Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens, Arisaema Cum Bile, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Raphani, Fructus Perillae, Semen Sinapis Albae, for treatment abundant expectoration person.

7, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 1, it is characterized in that: described compound recipe can add Radix Paeoniae, for treatment abdominal part anxiety, neck stiffness, muscle contraction person.

8, the Chinese herb compound in order to the treatment multiple pumping symptoms according to claim 1, it is characterized in that: described compound recipe can add the Radix Angelicae Dahuricae, Flos Magnoliae, Fructus Xanthii, for treatment rhinitis or twang symptom is arranged.

9, a kind of pharmaceutical composition of Chinese herb compound in order to the treatment multiple pumping symptoms, it is characterized in that, comprise that its amount is for can effectively treating, slow down or suppress multiple pumping symptoms according to the Chinese herb compound and the pharmaceutically acceptable carrier that define in the claim 1;

Whereby, group constitutes a pharmaceutical composition in order to the treatment multiple pumping symptoms.