CN102908396A - Chinese medicinal composition for promoting sleeping and preparation method thereof - Google Patents
Chinese medicinal composition for promoting sleeping and preparation method thereof Download PDFInfo
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- CN102908396A CN102908396A CN2012104765130A CN201210476513A CN102908396A CN 102908396 A CN102908396 A CN 102908396A CN 2012104765130 A CN2012104765130 A CN 2012104765130A CN 201210476513 A CN201210476513 A CN 201210476513A CN 102908396 A CN102908396 A CN 102908396A
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Abstract
The invention belongs to the field of Chinese medicaments, and discloses a Chinese medicinal composition for promoting sleeping and a preparation method thereof. The Chinese medicinal composition is prepared from silk tree flower, jasmine flower, linden blossom and liquorice, and has the functions of calming and tranquilizing. All Chinese medicaments in the Chinese medicinal composition influence with one another, and are synergic to play the roles of calming and tranquilizing, prolonging sleeping time and improving sleeping quality, so that the Chinese medicinal composition is short in course of treatment and quick in response. The medicinal materials used in the invention are non-toxic, so that the Chinese medicinal composition is small in drug dependence after long-term use, and low in price, is suitable for patients with short term and long term insomnia, and has wide market prospect.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition with hypnotic effect and preparation method thereof.
Background technology
Insomnia is sleep disorder, is owing to feelings will, diet internal injury, or reaches after being ill the causes of disease such as old, innate deficiency, timidness due to deficiency of the heart, causes lack of preservation of spirit or irritability, thereby causes often can not obtaining the class disease that ortho sleep is feature.Insomnia is one of common clinical disease, shows as difficulty falling asleep, and is intermittently discontinuous, and wakes up prematurely, can not continue to sleep after waking up again, and do not have enough sleep malaise, asthenia sensation.Though insomnia does not belong to critical illness, but can cause the imbalance of intestinal microbial population, cause that constipation, diarrhoea, mottle seat skin ulcer, immunity of organisms descend, the phenomenons such as intestinal can not normal creepage of gastrointestinal functions, colour of skin flavescence, hinder people orthobiosis, work, study and health, and can increase the weight of or bring out the diseases such as cardiopalmus, the thoracic obstruction, dizzy, headache, apoplexy.Obstinate insomnia brings long-term misery to patient, even forms the dependence to the medicine of sleeping peacefully, and the long-term taking medicine of sleeping peacefully can cause iatrogenic disease.
At present, the phenobarbital class Drug therapy insomnias such as many employings both at home and abroad are stable, estazolam, ALprazolanic, clonazepam, fludiazepam, these curative effect of medication are definite, initial stage can reach the effect of getting instant result, play the number of times of awakening less night, increase total sleep time, improve the effects such as sleep quality, but long-term taking can produce certain side effect to health, produce drug resistance and dependency, the symptoms such as sleepy, drowsiness, weak, dizzy occur, also may occur ataxia when heavy dose of, temporaryly forget and the untoward reaction such as disturbance of consciousness.And Chinese traditional treatment is from integral body, is aided with tranquilizing the mind on reinforce insufficiency and reduce excessiveness, the basis of adjusting the internal organs negative and positive of qi and blood, and clinical efficacy is good, but side effect is little and the equal nontoxic life-time service of medical material.
The traditional Chinese medical science claim insomnia for be insomnia, insomnia etc., in pathogenic fire derived from stagnation of liver-QI, the expectorant heat around, become silted up and disturb the basic pathogenesis as having a sleepless night such as the mind, hyperactivity of fire caused by deficiency of YIN, deficiency of both the heart and spleen, the heart and gallbladder deficiency of vital energy.At present commercially available Chinese patent drugs for treatment insomnia effect relaxes, and truly has certain curative effect, but compatibility is complicated mostly, the course for the treatment of of taking medicine is long, cure rate is low.Therefore, to take compatibility Chinese medicine preparation simple, evident in efficacy significant to improving sleep in research and development.
Summary of the invention
In view of this, the object of the present invention is to provide the Chinese medicine composition that a kind of compatibility is simple, effect has the hypnotic effect significantly.
For realizing purpose of the present invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition with hypnotic effect, made by the crude drug of following weight portion:
1 ~ 3 part in 1 ~ 3 portion of Radix Glycyrrhizae of 1 ~ 5 part of Tilia europaea of 1 ~ 5 portion of Flos Jasmini Sambac of Flos Albiziae.
The record of traditional Chinese medical science ancient books: " yang-energy is most, and is cloudy arrogant, then blurring of vision; Cloudy gas is most, and yang-energy is contained, then awake." this is the classic explanation to sleep, when yang-energy decline, when cloudy gas rises, will cause sleep; Prosperous and powerful when yang-energy, during cloudy gas crock up, the people will awaken.In addition, the sleep also and liver, the heart, spleen, lung, kidney and the synergism between them closely related.Chinese medicine composition of the present invention selects the four flavor Chinese crude drugs such as Flos Albiziae, Flos Jasmini Sambac, 1 ~ 3 part of Tilia europaea and Radix Glycyrrhizae to make for the bad formed main mechanism of sleep, and fundamentally negative and positive in the control agent are calmed and calmed the nerves hypnotic.
Wherein, Flos Albiziae has another name called that silk tree is joyous, Flos Albiziae, velvet flowers tree, bird floss tree, is the dry inflorescence of leguminous plant Herba Albiziae Albizia julibrissin Durazz..Flos Albiziae is warm in nature, and sweet-bitter flavor is nontoxic, GUIXIN, spleen channel, the effects such as tool resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, pathogenic wind expelling make eye bright, promoting blood circulation and stopping pain have calming effects simultaneously, are mainly used in treating the diseases such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.
Flos Jasmini Sambac has another name called a kind of apple flower, oblonga flower, is the flower of Oleaceae shrub plant jasmine.Flos Jasmini Sambac is flat, and acrid in the mouth, sweet has removing dampness for regulating stomach, an effect such as the resolving depression of regulating the flow of vital energy, and is mainly used in that the taste turbid damp does not change, eats less that gastral cavity is vexed, the diseases such as diarrhoea or dysentery stomachache.
Tilia europaea has another name called Flos Tiliae, is the inflorescence of Tiliaceae plant tilia miqueliana.Tilia europaea is warm in nature, and acrid in the mouth, sweet enters lung meridian, has the effects such as relieving the exterior syndrome by diaphoresis, pain relieving spasmolytic, be mainly used in spasmolytic, convergence, cough-relieving, sharp brain, eliminate nasal obstruction, diuresis, make skin soft, reduce blood pressure, sharp neural, calm, promote diaphoresis, mend body.
Radix Glycyrrhizae, another name Herba Hedyotis cantonensis root, Radix Glycyrrhizae, Radix Glycyrrhizae are dicotyledon pulse family Radix Glycyrrhizae (Glycyrrhizauralensis Fisch.), the root and rhizome of Glycyrrhiza inflata Bat. (G.inflata Bat.) or Glycyrrhiza glabra L. (G.glabra L.), be a kind of tonification Chinese herbal medicine, detoxifcation is arranged, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.Clinical practice divides " give birth to and use " and " processed with honey " not." give birth to " Radix Glycyrrhizae has another name called Radix Glycyrrhizae, SHENGCAO, and Radix Glycyrrhizae is for crude drug is removed impurity, cleaned, runs through the section life with being used as medicine; " processed with honey " has another name called Radix Glycyrrhizae Preparata, Radix Glycyrrhizae Preparata, Radix Glycyrrhizae, Radix Glycyrrhizae (processed with honey), and the Radix Glycyrrhizae tabellae of making a living is mixed thoroughly with Mel, fries to tack-free taking-up airing again, then is used as medicine.Radix Glycyrrhizae of the present invention is Radix Glycyrrhizae, sweet in the mouth, property are put down, GUIXIN, lung, spleen, stomach warp, have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, it is strong to be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity.
Flos Albiziae described in the present invention, Flos Jasmini Sambac, Tilia europaea and Radix Glycyrrhizae are well known to a person skilled in the art, can by commercial sources from pharmacy buy obtain or by disclosed method cultivation the prior art, gathering obtains, its specification meets country or industry standard gets final product.Used medical material is all nontoxic simultaneously, and the long-term taking drug dependence is little, and cheap, is fit to ordinary consumer and uses.
As preferably, Chinese medicine composition of the present invention, made by following weight portion raw material:
1.5 parts in 1.5 portions of Radix Glycyrrhizaes of 3 parts of Tilia europaea of 3 portions of Flos Jasmini Sambacs of Flos Albiziae
The present invention also provides the preparation method of described Chinese medicine composition, for getting 1 ~ 5 weight portion Flos Albiziae, 1 ~ 5 weight portion Flos Jasmini Sambac, 1 ~ 3 weight portion Tilia europaea and the rear mixing of 1 ~ 3 weight portion Radix Glycyrrhizae pulverizing and get final product.
Further, preparation method of the present invention also comprises the step of described raw material being carried out respectively washing and drying.
The present invention also provides the clinical preparation of described Chinese medicine composition.It is the required various pharmaceutically adjuvants of routine that those skilled in the art can add the preparation different dosage form with Chinese medicine composition of the present invention according to different patients' demand, such as disintegrating agent, lubricant, emulsifying agent, binding agent etc., with conventional method of Chinese medicinal, make common dosage forms through the direct or indirect adding acceptable adjuvant pharmaceutically of routine processing.
Preferably, the clinical preparation of Chinese medicine composition of the present invention is granule or oral liquid, is easy to use, and with strong points, curative effect is obvious.
Using dosage and the using method of pharmaceutical composition of the present invention depend on factors, comprise activity intensity, service time, metabolic rate, the course of disease order of severity and diagnosis and treatment doctor's the subjective judgment of patient's age, body weight, sex, natural health situation, nutriture, chemical compound.Those skilled in the art can easily determine using dosage and the using method of pharmaceutical composition according to above-mentioned factor.
The present invention also provides the health product that comprise Chinese medicine composition of the present invention.
Preferably, the health product of Chinese medicine composition of the present invention are health tea.
The present invention also provides described preparation method with health tea of hypnotic effect, for Chinese medicine composition of the present invention being packed into tea bag and get final product.
The present invention is through clinical observation on the therapeutic effect, in 150 routine insomniacs, take Chinese medicinal composition granules of the present invention after 7 days, 136 cases got cured, cure rate accounts for 90.7%, 11 examples take a turn for the better, obvious effective rate accounts for 7.3%, and total effective rate is 98.0%, invalid 3 examples, inefficiency accounts for 2.0%, shows that the Chinese medicine composition with hypnotic effect of the present invention is evident in efficacy.In 180 routine insomniacs, use Chinese medicine composition health tea of the present invention, cure rate accounts for 85.0%, and effective percentage is 97.2%, shows that the Chinese medicine composition health tea with hypnotic effect of the present invention is evident in efficacy.In the patient who treats, do not have an example untoward reaction to occur, show that Chinese medicine composition of the present invention and described Chinese medicine composition health tea are nontoxic to human-body safety.
The invention provides a kind of Chinese medicine composition with hypnotic effect.Chinese medicine composition of the present invention is that raw material is prepared from by Flos Albiziae, Flos Jasmini Sambac, Tilia europaea and Radix Glycyrrhizae, the Chinese medicine of respectively distinguishing the flavor of in the described Chinese medicine composition influences each other, synergism, play the effect of well feeling at ease to repose, prolong the length of one's sleep, raising sleep quality, it is evident in efficacy to improve sleep, short treating period, instant effect.The used medical material of simultaneously the present invention is all nontoxic, and the life-time service drug dependence is little, and cheap, and the patient who is fit to short-term and long-term insomnia uses, and has wide market prospect.
The specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition with hypnotic effect and preparation method thereof.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are deemed to be included in the present invention.Method of the present invention is described by preferred embodiment, and the related personnel obviously can change or suitably change and combination method as herein described within not breaking away from content of the present invention, spirit and scope, realizes and use the technology of the present invention.
In order further to understand the present invention, be elaborated to the invention provides below in conjunction with embodiment.
Embodiment 1: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is to be made by following crude drug: Flos Albiziae 1g, Flos Jasmini Sambac 5g, Tilia europaea 1g, Radix Glycyrrhizae 3g.
Preparation method is after said medicine is washed respectively, dries, pulverized, and mixes by weight ratio at normal temperatures and get final product.
Embodiment 2: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is to be made by following crude drug: Flos Albiziae 5g, Flos Jasmini Sambac 1g, Tilia europaea 3g, Radix Glycyrrhizae 1g.
Preparation method is after said medicine is washed respectively, dries, pulverized, and mixes by weight ratio at normal temperatures and get final product.
Embodiment 3: the Chinese medicine composition with hypnotic effect of the present invention
Described Chinese medicine composition is to be made by following crude drug: Flos Albiziae 3g, Flos Jasmini Sambac 3g, Tilia europaea 1.5g, Radix Glycyrrhizae 1.5g.
Preparation method is after said medicine is washed respectively, dries, pulverized, and mixes by weight ratio at normal temperatures and get final product.
Embodiment 4: the granule with Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of getting embodiment 3 gained mixes with adjuvant commonly used according to a conventional method and makes the Chinese medicine granules with hypnotic effect of the present invention.
Embodiment 5: the oral liquid with Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of getting embodiment 3 gained mixes with adjuvant commonly used according to a conventional method and makes the Chinese medicine oral liquid with hypnotic effect of the present invention.
Embodiment 6: the health tea with Chinese medicine composition of hypnotic effect of the present invention
The Chinese medicine composition of getting embodiment 3 gained is packed in the tea bag and be get final product.
Embodiment 7: the observation of curative effect of Chinese medicine composition of the present invention
300 routine insomniacs are divided into experimental group and matched group at random, every group of 150 examples, granule and the classical Chinese medicine prescription suanzaoren decoction of the Chinese medicine composition of Application Example 4 preparations are treated respectively.
Therapeutic Method: experimental group is taken the granule of Chinese medicine composition of the present invention sooner or later, stops other western medicines in treatment during the treatment.Matched group is taken classical Chinese medicine prescription suanzaoren decoction sooner or later, stops other western medicines in treatment during the treatment.
Observation of curative effect: the present invention has obtained preferably curative effect clinically, in 150 routine insomniacs, takes Chinese medicinal composition granules of the present invention after 7 days, 136 cases got cured, cure rate accounts for 90.7%, 11 examples that take a turn for the better, and obvious effective rate accounts for 7.3%, total effective rate is 98.0%, invalid 3 examples, and inefficiency accounts for 2.0%.The matched group cure rate is that 67.3%, two group of cure rate relatively has significant difference (P＜0.05).
Embodiment 8: the clinical observation on the therapeutic effect of Chinese medicine composition of the present invention:
Permitted certain, man 50 years old, retired worker.For many years insomniac, have difficulty in going to sleep every day for a long time, and it is more shallow to sleep, and dreaminess, easily wakes up, thereby cause health to be become thin, and lassitude is off one's feed, and often feels dizzy, mood is irritated.The granule that uses the embodiment of the invention 4 to make, used continuously for 1 week after, it is stable sleep, sleep is dark, less dream, lassitude, the resolution of symptoms of being off one's feed; After using for 2 weeks continuously, it is normal that sleep recovers, and the insomnia complete obiteration is happy, in high spirits.
Zhang, woman 15 years old, middle school student.Because learning pressure is suffered from insomnia 2 months, poor sleep can not be fallen asleep, and can't fall asleep the whole night when serious, and is listless, and mood is irritated, and second day does not have energy study yet.The granule that uses the embodiment of the invention 4 to make, took continuously for 1 week after, various insomnias disappear, and are happy, in high spirits.
Lee, man 20 years old, university students.Suffered from insomnia existing 1 year, it is more shallow to sleep, dreaminess.The granule that uses the embodiment of the invention 4 to make, took continuously for 1 week after, various insomnias disappear, it is stable to sleep, it is darker to sleep.
Embodiment 9: the clinical observation on the therapeutic effect of health tea of the present invention
Observe the curative effect of using health tea of the present invention.
Select case 180 examples in outpatient service or ward, male 82 examples, women 98 examples, age circle, the course of disease was the shortest 2 months in 15～60 years old, and is the longest 10 years.
Therapeutic Method: use the embodiment of the invention 6 described Chinese medicine composition health teas, used continuously for 2 weeks, during stop using other Chinese medicine and western medicine and health product.
Therapeutic outcome: cure 153 examples, account for 85.0%; Effective 22 examples account for 12.2%; Invalid 5 examples account for 2.8%.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (9)
1. the Chinese medicine composition with hypnotic effect is characterized in that, is made by the raw material of following weight portion:
1 ~ 3 part in 1 ~ 3 portion of Radix Glycyrrhizae of 1 ~ 5 part of Tilia europaea of 1 ~ 5 portion of Flos Jasmini Sambac of Flos Albiziae.
2. described Chinese medicine composition according to claim 1 is characterized in that, is made by following weight portion raw material:
1.5 parts in 1.5 portions of Radix Glycyrrhizaes of 3 parts of Tilia europaea of 3 portions of Flos Jasmini Sambacs of Flos Albiziae.
3. the preparation method of the Chinese medicine composition of a sleeping is characterized in that, get 1 ~ 5 weight portion Flos Albiziae, 1 ~ 5 weight portion Flos Jasmini Sambac, 1 ~ 3 weight portion Tilia europaea and 1 ~ 3 weight portion Radix Glycyrrhizae pulverize after mixing and get final product.
4. the Chinese medicine composition of the described preparation method of claim 3 preparation.
5. the Chinese medicine preparation with hypnotic effect is characterized in that, is made by claim 1,2 or 4 described Chinese medicine compositions and pharmaceutically acceptable adjuvant.
6. described clinical preparation according to claim 5 is characterized in that it is granule or oral liquid.
7. comprise claim 1,2 or 4 described health product with Chinese medicine composition of hypnotic effect.
8. described health product according to claim 7 is characterized in that it is health tea.
9. the preparation method with health tea of hypnotic effect is characterized in that, packs into claim 1,2 or 5 described compositionss in the tea bag and get final product.
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| CN201210476513.0A CN102908396B (en) | 2012-11-21 | 2012-11-21 | Chinese medicinal composition for promoting sleeping and preparation method thereof |
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| CN201210476513.0A CN102908396B (en) | 2012-11-21 | 2012-11-21 | Chinese medicinal composition for promoting sleeping and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104083495A (en) * | 2014-06-17 | 2014-10-08 | 刘海强 | Traditional Chinese medicine for treating senile asomnia |
| CN105053421A (en) * | 2015-09-17 | 2015-11-18 | 上海秋橙新材料科技有限公司 | Tranquilizing tea |
| CN107990284A (en) * | 2017-11-29 | 2018-05-04 | 朱应长 | A lampshade with sleeping function |
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| CN101181382A (en) * | 2007-12-05 | 2008-05-21 | 姜莉蔚 | Chinese medicine emplastrum for soothing the mind to sleep |
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| CN101181382A (en) * | 2007-12-05 | 2008-05-21 | 姜莉蔚 | Chinese medicine emplastrum for soothing the mind to sleep |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104083495A (en) * | 2014-06-17 | 2014-10-08 | 刘海强 | Traditional Chinese medicine for treating senile asomnia |
| CN104083495B (en) * | 2014-06-17 | 2016-05-11 | 刘海强 | A kind of Chinese medicine that is used for the treatment of senile insomnia |
| CN105053421A (en) * | 2015-09-17 | 2015-11-18 | 上海秋橙新材料科技有限公司 | Tranquilizing tea |
| CN107990284A (en) * | 2017-11-29 | 2018-05-04 | 朱应长 | A lampshade with sleeping function |
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