CN105055761A - Traditional Chinese medicine for treatment of qi and blood deficiency type postpartum depression and preparation method thereof - Google Patents

Traditional Chinese medicine for treatment of qi and blood deficiency type postpartum depression and preparation method thereof Download PDF

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CN105055761A
CN105055761A CN201510478079.3A CN201510478079A CN105055761A CN 105055761 A CN105055761 A CN 105055761A CN 201510478079 A CN201510478079 A CN 201510478079A CN 105055761 A CN105055761 A CN 105055761A
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张叶梅
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Abstract

The invention provides a traditional Chinese medicine for treatment of qi and blood deficiency type postpartum depression and a preparation method thereof. The traditional Chinese medicine comprises the following crude drugs: fortune windmillpalm wood, fruit of Celastrus orbiculatus Thunb, Salvia yunnanensis, root of Tomentoseflower Larkspour, Cyperus michelianus, Typha angustata Boryet Chaub., Flemingia Philippinensis, Parochetus communis, Helixanthera parasitica, Ventilago leiocarpa Benth, Polygala aureocauda Dunn, Lethariella cladonioides, Cratoneuron filicinum, Goodyera schlechtendaliana, salvia, Upupa epops, oreas herb, and Bridelia tomentosa Blume. The traditional Chinese medicine provided by the invention has definite efficacy on qi and blood deficiency type postpartum depression, and has small toxic and side effect.

Description

A kind ofly treat Chinese medicine of both Qi and blood deficiency postpartum depression and preparation method thereof
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to and a kind ofly treating Chinese medicine of both Qi and blood deficiency postpartum depression and preparation method thereof.
Background technology
Postpartum depression is, anorexia depressed with puerperal, tired, sleep disorder, absent minded and deal with baby uncomfortable etc. for a kind of nervous symptoms of feature depressed.Hallucination, autotomy, suicide can be there is time serious.Sickness rate constantly increases in recent years, and the course of disease can delay the several months to the several years, not only the physical and mental health of serious harm puerpera, and may cause cognitive competence, personality, emotion, the behavior disorder of baby.
Current western medical treatment mainly takes antidepressant drug, though there is certain curative effect, such medicine likely produces drug dependence and has certain toxic and side effects.
Postpartum depression belongs to the categories such as " puerperal goes mad ", " puerperal is demented " " hysteria in puerperal " by its clinical manifestation.The traditional Chinese medical science thinks that puerperal, the mistake of blood deficiency internal organs was supported as its Etiological, and patient's ferritic is weak insufficiency of the spleen, or vomiting during pregnancy, essence and blood biochemistry is passive, and after gestation, the poly-lower fetus nourishing of blood, loses blood when producing in addition, to puerperal blood deficiency more very, blood deficiency the liver failing to be nourished, depression of liver-QI, catharsis is neglected one's duty, or puerperal hinder in seven emotions, depressed emotion, liver is lost bar and reaches, and develops into postpartum depression.
Summary of the invention
Technical problem to be solved by this invention is, provide a kind of and treat Chinese medicine of both Qi and blood deficiency postpartum depression and preparation method thereof, Chinese medicine of the present invention has definite curative effect to both Qi and blood deficiency postpartum depression, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of both Qi and blood deficiency postpartum depression, its raw medicinal material comprises: Lignum Trachycarpi, fruits of Celastrus orbiculatus Thunb, Salvia miltiorrhiza Bge, Rhizoma Arisaematis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) Rhizoma typhae, Radix Flemingiae Philippinensis, Flos Caraganae Sinicae, Ramulus et Folium Loranthi Pentapetali, Radix seu Caulis Verntilaginis Leiocarpae, Radix Polygalae fallacis, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Paphio-pedilum micranthum Tang et Wang, red palpus palpus, Upupa epops L., Oreas martiana (Hopp. Et Hornsch.) Brid. and Bridelia monoica (Lour.) Merr..
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Lignum Trachycarpi 10 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 35 ~ 45 parts, Salvia miltiorrhiza Bge 5 ~ 15 parts, Rhizoma Arisaematis 10 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 ~ 25 parts of , Rhizoma typhae 15 ~ 25 parts, Radix Flemingiae Philippinensis 15 ~ 25 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 ~ 45 parts, Radix Polygalae fallacis 10 ~ 20 parts, 15 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 10 ~ 20 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 25 parts, red palpus palpus 10 ~ 25 parts, Upupa epops L. 10 ~ 20 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 15 ~ 25 parts and Bridelia monoica (Lour.) Merr. 35 ~ 45 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Lignum Trachycarpi 15 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 40 ~ 45 parts, Salvia miltiorrhiza Bge 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 ~ 20 parts of , Rhizoma typhae 15 ~ 20 parts, Radix Flemingiae Philippinensis 20 ~ 25 parts, Flos Caraganae Sinicae 15 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 38 ~ 45 parts, Radix Polygalae fallacis 15 ~ 20 parts, 20 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 13 ~ 18 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 20 parts, red palpus palpus 14 ~ 22 parts, Upupa epops L. 10 ~ 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 ~ 25 parts and Bridelia monoica (Lour.) Merr. 38 ~ 45 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lignum Trachycarpi 16 parts, fruits of Celastrus orbiculatus Thunb 44 parts, Salvia miltiorrhiza Bge 12 parts, Rhizoma Arisaematis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 17 parts of , Rhizoma typhae 18 parts, Radix Flemingiae Philippinensis 20 parts, Flos Caraganae Sinicae 19 parts, Ramulus et Folium Loranthi Pentapetali 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 39 parts, Radix Polygalae fallacis 19 parts, 23 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 15 parts, Paphio-pedilum micranthum Tang et Wang 16 parts, red palpus palpus 20 parts, Upupa epops L. 12 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 23 parts and Bridelia monoica (Lour.) Merr. 38 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lignum Trachycarpi 19 parts, fruits of Celastrus orbiculatus Thunb 41 parts, Salvia miltiorrhiza Bge 15 parts, Rhizoma Arisaematis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 parts of , Rhizoma typhae 15 parts, Radix Flemingiae Philippinensis 23 parts, Flos Caraganae Sinicae 15 parts, Ramulus et Folium Loranthi Pentapetali 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 42 parts, Radix Polygalae fallacis 16 parts, 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 18 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, red palpus palpus 15 parts, Upupa epops L. 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 parts and Bridelia monoica (Lour.) Merr. 43 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to both Qi and blood deficiency postpartum depression, and toxic and side effects is little.
Detailed description of the invention
The invention provides a kind of Chinese medicine for the treatment of both Qi and blood deficiency postpartum depression, its raw medicinal material comprises: Lignum Trachycarpi, fruits of Celastrus orbiculatus Thunb, Salvia miltiorrhiza Bge, Rhizoma Arisaematis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) Rhizoma typhae, Radix Flemingiae Philippinensis, Flos Caraganae Sinicae, Ramulus et Folium Loranthi Pentapetali, Radix seu Caulis Verntilaginis Leiocarpae, Radix Polygalae fallacis, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Paphio-pedilum micranthum Tang et Wang, red palpus palpus, Upupa epops L., Oreas martiana (Hopp. Et Hornsch.) Brid. and Bridelia monoica (Lour.) Merr..
In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:
Lignum Trachycarpi: [source] medical material Ji Yuan: be the heartwood of babassu Petiolus Trachycarpi.Gather and store: the whole year all can gather, removing peel of stem, get xylem, cutting is dried.[nature and flavor] bitter in the mouth; Puckery; Property is put down.[return through] heart; Spleen channel.[function cures mainly] tranquilizing by nourishing the heart; Astringing to arrest bleeding.Main cardiopalmus; Dizzy; Metrorrhagia; Proctoptosis; Uterine prolapse.[extracts] " China's book on Chinese herbal medicine "
Fruits of Celastrus orbiculatus Thunb: [another name] Flos Albiziae, Canis familiaris L. Ge Zi, skin monkey, crow tit food.[source] medical material Ji Yuan: be the fruit of Celastraceae plant Celastrus orbiculatus Thunb. CelastrusorbiculatusThunb..Gather and store: between the 9-10 month, taking after fruit maturation, dry.[nature and flavor] are sweet; Micro-hardship; Flat.[function cures mainly] tranquilizing by nourishing the heart; Regulating blood flow to alleviate pains.Main palpitation and insomnia; Forgetful dreaminess; Toothache; Bones and muscles pain; Waist lower limb is numb; Traumatic pain.[extracts] " China's book on Chinese herbal medicine "
Salvia miltiorrhiza Bge: [another name] Radix Salviae Miltiorrhizae, little Radix Salviae Miltiorrhizae, Radix Salviae Miltiorrhizae, Radix Rubiae Yunnanensis, small red grass crow, little RADIX SALVIAE MILTIORRHIZAE, Radix Orthosiphonis Wulfenioidis, Yunnan Radix Salviae Miltiorrhizae, tor Radix Salviae Miltiorrhizae.[source] medical material Ji Yuan: be the root of labiate Yunnan Salvia japonica Thunb..Latin plant animal mineral name: SalviayunnanensisC.H.Wright.Gather and store: summer, autumn excavate, removing impurity, dries.[nature and flavor] mildly bitter flavor; Micro-sweet; Cold nature.[return through] heart; Liver Channel.[function cures mainly] blood circulation promoting and blood stasis dispelling; Cooling blood for hemostasis; Tranquilizing by nourishing the heart; Removing toxic substances and promoting subsidence of swelling.Main menoxenia; Dysmenorrhea; Amenorrhea; Lochia is suffered from abdominal pain; Thoracic obstruction angor; Arthralgia; Colic; Metrorrhagia; Spit blood; Epistaxis; Hemoptysis; Numbness of extremities due to deficiency of blood; Insomnia; Forgetful; Palpitation with fear; Palpitation with a distress feeling; Acute mastitis; Skin ulcer swells; Traumatic injury congestive edema.[extracts] " China's book on Chinese herbal medicine "
Rhizoma Arisaematis: [another name] Rhodobryum giganteum(Hook.) Par., Rhodobryum giganteum, Hui Xincao, little Herba Asteris faberi, Ah receipts chicken, Plagiopus oederi (Brid.) Limpr.(Polytrichum annotinum L.), Rhodobryum roseum Limpr..[source] medical material Ji Yuan: for Bryaceae plant warms up the plant of ground great Ye moss.Gather and store: summer, autumn gather, drying or using fresh herb.[nature and flavor] are pungent; Bitter; Flat.[function cures mainly] tranquilizing by nourishing the heart; Liver heat removing and eyesight improving.Main severe palpitation; Neurasthenia; Conjunctival congestion and swelling pain; Coronary heart disease; Hypertension etc.[extracts] " China's book on Chinese herbal medicine "
Cyperus michelianus(L.) Link (Herba Cyperi Micheliani): [another name] attached heart grass (" classifying herbal ").[source] revolves the herb of squama dried tuber for sedge.Gather during result.[nature and flavor] 1. " classify herbal ": " hot in nature."。[function cures mainly] 1. " classifies herbal ": " nourishing blood for regulating menstruation." [extracts] " Chinese medicine voluminous dictionary "
Rhizoma typhae: [another name] Pollen Typhae root (" galactopoiesis collection proved recipe "), Pu Radix Crotalariae szemoensis (" daily book on Chinese herbal medicine "), Pu root (" wild herbs spectrum "), rush bag grass roots (" Chinese herbal medicine is commonly used in Shanghai ").[source] for Typhaceae plant typha angustata or its belong to the rhizome with part tender stem of various plants together.Spring excavates.[nature and flavor] are sweet, cool.[function cures mainly] clearing away heat and cooling blood, inducing diuresis to remove edema.Control anemia of pregnant woman's consumptive fever, vaginal bleeding due to excessive movement of fetus, quench one's thirst, aphtha, hematodiarrhoea, gonorrhea, leucorrhea, edema, scrofula.[extracts] " Chinese medicine voluminous dictionary "
Radix Flemingiae Philippinensis: [another name] Flemingia philippinensis, Glycine tomentella, rat tail, hang Ma Dun, hang hitching post, Taurus tail, arrow root, Radix Flemingiae Philippinensis, colour of loess a kind of reed mentioned in ancient books [Guangxi, Guangdong], Cortex schizophragmatis integrifolii radicis [Sichuan].[source] is pulse family Moghania plant Radix Flemingiae Philippinensis, is used as medicine with root.Spring, autumn excavate, and clean section is dried, also can using fresh herb.[nature and flavor] are sweet, tepor, flat.[function cures mainly] wind-damp dispelling, strong waist knee joint.For rheumatic arthritis, lumbago and skelalgia, lumbar muscle strain, leucorrhea, traumatic injury.[extracts] " national Chinese herbal medicine compilation "
Flos Caraganae Sinicae: [another name] dam tooth flower (herbal for Relief of Famines), gold magpie flower (" the southern regions of the Yunnan Province book on Chinese herbal medicine "), yellowbird flower (" detailed outline is picked up any lost article from the road "), Flos Caraganae Franchetianae (" vegetation is side just "), Ungula Sus domestica flower (" Fujian traditional herbal medicine "), axe flower, Trionyx sinensis Wiegmann mouth flower (" Zhejiang Chinese medicine handbook "), Yang Quehua (" Shaanxi Chinese herbal medicine ").[source] is the flower of leguminous plant caragana.Mid-April gathers, and dries, mothproof.[nature and flavor] are " the southern regions of the Yunnan Province book on Chinese herbal medicine " 1.: " slightly warm in nature, taste is sweet." [return through] " detailed outline is picked up any lost article from the road ": " enters liver, spleen two warp."。[function cures mainly] YIN nourishing, and blood, spleen invigorating.Control consumptive fever cough, the dizzy soreness of waist, women's deficiency of vital energy leucorrhea, infantile malnutrition, acute mastitis, injury from falling down.[extracts] " Chinese medicine voluminous dictionary "
Ramulus et Folium Loranthi Pentapetali: [another name] Flos Osmanthi Fragrantis is parasitic, kapok is parasitic, sleeve paulownia is parasitic, Lignum seu Ramulus Cunninghamiae Lanceolatae parasitic (" register planted by Guangxi medicine ").[source] is the branch and leaf of Loranthaceae plant Ramulus et Folium Loranthi Pentapetali.The whole year can adopt.[function cures mainly] " register planted by Guangxi medicine ": " eliminate the phlegm, dysentery relieving, dispels the wind, and detumescence, fills blood.Control dysentery, pulmonary tuberculosis, keratitis."。[extracts] " Chinese medicine voluminous dictionary "
Radix seu Caulis Verntilaginis Leiocarpae: [another name] Sinomenium acutum, car pusher enter stone, blue veins rattan (Guangzhou army " conventional Chinese herbal medicine handbook ").Root, stem that [source] is Rhamnaceae plant ventilago leiocarpa.The whole year can adopt, and clean section is dried.[nature and flavor] are sweet, temperature.[function cures mainly] benefiting vital QI and blood, dispelling, collateral-activating.Control deficiency of both QI and blood, rheumatalgia, traumatic injury.[extracts] " Chinese medicine voluminous dictionary "
Radix Polygalae fallacis: [another name] Hemerocallis citrina Baroni ginseng, chicken young tree, DIAOHUANG, Hemerocallis citrina Baroni use water lotus, kwan-yin string, the large Radix Polygalae of Hemerocallis citrina Baroni, Radix polygalae arillatae, DIAOHUANG, hang upside down Hemerocallis citrina Baroni, hang upside down Huang, Hemerocallis citrina Baroni gold helmet, kwan-yin pendant, Hemerocallis citrina Baroni Herba Abri, gold print, read be good for, the ears of an ox or cow sound, Baima tire, the whole body be warming.[source] medical material Ji Yuan: be root or stem, the leaf of milk wort Radix Polygalae fallacis.[nature and flavor] are sweet; Micro-hardship; Property is put down.[return through] liver; Kidney; Spleen channel.The spleen invigorating of [function cures mainly] tonify deficiency; Dissipating blood stasis dredging collateral.Main overstrain is weak; Uterine prolapse; Infantile malnutrition; Edema due to deficiency of the spleen; Leukorrhagia is rare clearly; Rheumatic arthralgia; Lumbago; Have through uncomfortable; Dysmenorrhea; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Spun gold brush: [another name] Cladonia fallax Abbayes.[source] medical material Ji Yuan: be the thallus of Parmeliaceae plant spun gold brush.[nature and flavor] are bitter; Property is put down.[return through] heart; Liver Channel.[function cures mainly] calms the nerves; Suppressing the hyperactive liver; Invigorate blood circulation; Sore.Main insomnia; Epilepsy; Dizzy; Traumatic injury; Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "
Cratoneuron filicinum (Hedw.) Spruc.(Lolsk): [another name] short leaf Cratoneuron filicinum (Hedw.) Spruc.(Lolsk).[source] medical material Ji Yuan: be the plant of Amblystegiaceae Cratoneuron filicinum (Hedw.) Spruc.(Lolsk).[nature and flavor] are light; Micro-puckery; Flat.[return through] heart channel.[function cures mainly] tranquilizing by nourishing the heart.Main irritability; Palpitation with fear palpitation with a distress feeling.[extracts] " China's book on Chinese herbal medicine "
Paphio-pedilum micranthum Tang et Wang: [another name] Herba goodyearae repentis.[source] medical material Ji Yuan: be the herb of orchid Paphiopedilum micranthum.Gather and store: summer, autumn gather, and dry.[nature and flavor] are bitter; Cool.[return through] lung; The heart; Kidney channel.[function cures mainly] clearing heat for promoting eruption; Clearing away heart-fire for tranquillization.Djumah rash; Pneumonia; Vexed insomnia.[each discussion] " Xinhua book on Chinese herbal medicine outline ": herb: bitter in the mouth, cool in nature.There is heat-clearing and toxic substances removing, the function of cerebral tonic tranquillizing.For measles, pneumonia, neurasthenia.[extracts] " China's book on Chinese herbal medicine "
Red palpus palpus: [another name] Salvia lankongensis C. Y. Wu..[source] medical material Ji Yuan: be the root of labiate Salvia lankongensis C. Y. Wu..Gather and store: summer, autumn excavate, cleaning, dry.[nature and flavor] bitter in the mouth; Cold nature.[return through] liver; Heart channel.[function cures mainly] promoting blood flow to regulate menstruation; Stasis-dispelling and pain-killing.Main menoxenia; Dysmenorrhea; Amenorrhea; Ectopic pregnancy hepatosplenomegaly; Thoracic obstruction angor; Dysphoria and insomnia; Sore and toxic.[extracts] " China's book on Chinese herbal medicine "
Upupa epops L.: [another name] cockscomb bird, hoopoe, Hu .[source] is the full bird of Upupidae animal hoopoe.The whole year can catch, unhairing and the intestines and stomach, cleans, and roasting Huang grinds for subsequent use or using fresh herb into powder.[function cures mainly] easing the affected liver relieves dizziness, high fever, infantile convulsions, epilepsy, etc., tranquilizing mind.Control epilepsy, psychosis, malaria.[extracts] " Chinese medicine voluminous dictionary "
Oreas martiana (Hopp. Et Hornsch.) Brid.: [source] is the herb of Dicranaceae plant mountain hair moss.The whole year gathers, use of drying in the shade.[nature and flavor] slightly sweet flavor, property is put down.[function cures mainly] replenishing YIN and removing heat, tranquilizing the mind, expelling wind and removing dampness, hemostatic analgesia.Control osteopyrexia and fever, neurasthenia, rheumatalgia, demented, wound.[extracts] " Chinese medicine voluminous dictionary "
Bridelia monoica (Lour.) Merr.: [another name] Radix seu Herba Gymnopteris vestitae, supplementing the brain root, force son, tinkering a pan tree.[source] Euphorbiaceae Bridelia monoica (Lour.) Merr. Brideliamonoica (Lour.) Merr., is used as medicine with root bark, stem, leaf.[nature and flavor] light, micro-hardship, flat.[function cures mainly] calms the nerves regulating menstruation, heat-clearing and toxic substances removing.[extracts] " national Chinese herbal medicine compilation "
In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Lignum Trachycarpi 10 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 35 ~ 45 parts, Salvia miltiorrhiza Bge 5 ~ 15 parts, Rhizoma Arisaematis 10 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 ~ 25 parts of , Rhizoma typhae 15 ~ 25 parts, Radix Flemingiae Philippinensis 15 ~ 25 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 ~ 45 parts, Radix Polygalae fallacis 10 ~ 20 parts, 15 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 10 ~ 20 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 25 parts, red palpus palpus 10 ~ 25 parts, Upupa epops L. 10 ~ 20 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 15 ~ 25 parts and Bridelia monoica (Lour.) Merr. 35 ~ 45 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Lignum Trachycarpi 15 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 40 ~ 45 parts, Salvia miltiorrhiza Bge 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 ~ 20 parts of , Rhizoma typhae 15 ~ 20 parts, Radix Flemingiae Philippinensis 20 ~ 25 parts, Flos Caraganae Sinicae 15 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 38 ~ 45 parts, Radix Polygalae fallacis 15 ~ 20 parts, 20 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 13 ~ 18 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 20 parts, red palpus palpus 14 ~ 22 parts, Upupa epops L. 10 ~ 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 ~ 25 parts and Bridelia monoica (Lour.) Merr. 38 ~ 45 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Lignum Trachycarpi 16 parts, fruits of Celastrus orbiculatus Thunb 44 parts, Salvia miltiorrhiza Bge 12 parts, Rhizoma Arisaematis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 17 parts of , Rhizoma typhae 18 parts, Radix Flemingiae Philippinensis 20 parts, Flos Caraganae Sinicae 19 parts, Ramulus et Folium Loranthi Pentapetali 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 39 parts, Radix Polygalae fallacis 19 parts, 23 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 15 parts, Paphio-pedilum micranthum Tang et Wang 16 parts, red palpus palpus 20 parts, Upupa epops L. 12 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 23 parts and Bridelia monoica (Lour.) Merr. 38 parts.
In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Lignum Trachycarpi 19 parts, fruits of Celastrus orbiculatus Thunb 41 parts, Salvia miltiorrhiza Bge 15 parts, Rhizoma Arisaematis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 parts of , Rhizoma typhae 15 parts, Radix Flemingiae Philippinensis 23 parts, Flos Caraganae Sinicae 15 parts, Ramulus et Folium Loranthi Pentapetali 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 42 parts, Radix Polygalae fallacis 16 parts, 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 18 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, red palpus palpus 15 parts, Upupa epops L. 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 parts and Bridelia monoica (Lour.) Merr. 43 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: capsule
Get Lignum Trachycarpi 160g, fruits of Celastrus orbiculatus Thunb 440g, Salvia miltiorrhiza Bge 120g, Rhizoma Arisaematis 180g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 170g , Rhizoma typhae 180g, Radix Flemingiae Philippinensis 200g, Flos Caraganae Sinicae 190g, Ramulus et Folium Loranthi Pentapetali 110g, Radix seu Caulis Verntilaginis Leiocarpae 390g, Radix Polygalae fallacis 190g, spun gold brush 230g, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 150g, Paphio-pedilum micranthum Tang et Wang 160g, red palpus palpus 200g, Upupa epops L. 120g, Oreas martiana (Hopp. Et Hornsch.) Brid. 230g and Bridelia monoica (Lour.) Merr. 380g.
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.5:0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Embodiment 2: decoction
Get Lignum Trachycarpi 19g, fruits of Celastrus orbiculatus Thunb 41g, Salvia miltiorrhiza Bge 15g, Rhizoma Arisaematis 15g, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20g , Rhizoma typhae 15g, Radix Flemingiae Philippinensis 23g, Flos Caraganae Sinicae 15g, Ramulus et Folium Loranthi Pentapetali 14g, Radix seu Caulis Verntilaginis Leiocarpae 42g, Radix Polygalae fallacis 16g, spun gold brush 25g, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 18g, Paphio-pedilum micranthum Tang et Wang 20g, red palpus palpus 15g, Upupa epops L. 15g, Oreas martiana (Hopp. Et Hornsch.) Brid. 18g and Bridelia monoica (Lour.) Merr. 43g.
Prepare according to the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 5cm, soak 5 hours;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 50 minutes dosage to medicinal liquid be slowly 300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 6 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 23-32g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 1, (concentration is 8.96g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 44.8 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>44.8 crude drug/kg of the present invention, every day, maximum dosage-feeding was 89.6 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.143g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 28g) oral administration gavage Chinese medicine of the present invention is 626 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine embodiment 1 capsule of the present invention presses 15.82,23.66 and 45.86g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 110 routine cases are my Out-patient Department patient of in March, 2012 ~ 2014 year October.Patient is divided into treatment group and matched group at random, wherein treatment group 55 people, 22 ~ 40 years old age, primipara 38 example, multipara 17 example; Cesarean 30 example, spontaneous labor 25 example; Patients with mild 10 example, moderate patient 32 example, severe patient 13 example; Matched group 55 people, 23 ~ 40 years old age, primipara 39 example, multipara 16 example; Cesarean 32 example, spontaneous labor 23 example; Patients with mild 11 example, moderate patient 32 example, severe patient 12 example.Two groups in age, childbirth options, parturition number, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).
Diagnostic criteria: the diagnostic criteria according to postpartum depression in Americanism association " diagnostic & statistical manual of mental sickness ": the symptom (at least one item in first 2 must be possessed) occurring following more than 5 or 5 within two weeks puerperal: be 1. in a very depressed state; 2. to all or most movable interest and joyful of obviously lacking; 3. body weight significantly declines or increases; 4. insomnia or hypersomnia; 5. psychomotor excitement or retardance; 6. tired or weak; 7. all feel meaningless when anything crops up or have from crime sense; 8. thinking ability go down or attention defeated and dispersed; 9. repeatedly there is dead idea.All patients get rid of brain disorder, mental disorder history, mental disorder family history.Depressive illness is divided into 3 degree according to Hamilton depressive scale (HAMD scale) standards of grading: slight: total score at 8 ~ 20 points, moderate: total score at 21 ~ 35 points, severe: total score is more than 35 points.
Syndrome Differentiation of Traditional Chinese Medicine standard: both Qi and blood deficiency: absentminded, malaise, sad excellent happiness is cried, deficiency of QI with disinclination to talk, and difference of sleeping easily is waken up, anorexia loose stool, hypogalactia and clear, light red tongue, thready pulse.
Therapeutic Method:
Matched group: oral paroxetine, each 20mg, every day 1 time, 8 weeks courses for the treatment of.
Treatment group: give Chinese medicine embodiment 1 capsule of the present invention, each 4, every day 3 times.8 weeks courses for the treatment of.
Two groups all give psychological counseling, and adjustment patient emotion, establishes the confidence of Fighting Disease.
Curative effect judging standard: before treating, treated for 2,4,6,8 weekends, using the deduction rate of HAMD scale score as parameters for observation on effect, total mark before deduction rate=(before treatment the rear total mark of total mark-treatment)/treatment, adopt 4 grade standards that the whole nation is unified: clinical cure: transference cure, HAMD (deduction to 7 point below) deduction rate >=80%; Effective: symptom major part disappears, 50%≤HAMD deduction rate <80%; Take a turn for the better: symptom partial disappearance or degree alleviate, 25%≤HAMD deduction rate <50%; Invalid: symptom is unchanged or increase the weight of, HAMD deduction rate <25%.
Therapeutic outcome:
1, treatment group and comparing, in table 1 complying total effects.
A table 1 liang group patient total effects is compared as follows: (example)
Group n Clinical cure Effective Take a turn for the better Invalid Effectively total
Treatment group 55 19 22 9 5 51(90.9%)
Matched group 55 12 18 12 13 42(76.4%)
2, two groups of HAMD scorings are compared, in table 2.
A table 2 liang group HAMD scoring is compared
Group n Before treatment Treat 4 weeks Treat 6 weeks Treat 8 weeks
Treatment group 55 29.8±5.4 18.2±3.9 10.4±3.3 7.3±1.9
Matched group 55 29.6±6.1 22.4±5.3 15.7±4.1 10.2±2.5
3, untoward reaction: feeling sick appears in matched group 4 example, the gastrointestinal reactions such as vomiting, 2 examples have xerostomia, constipation, drowsiness untoward reaction of Denging.There is not any medicine related reactions in treatment group.Two groups of blood, urine, stool routine examination, all there is not abnormal change before and after the treatment such as electrocardiogram in Liver and kidney function.
Concrete case: high certain, women, 33 years old, primipara, there is absentminded in 2 months puerperal, malaise, like symptoms such as crying, husband is with it to see a doctor to hospital, and disease sees absentminded, malaise, sad excellent happiness is cried, deficiency of QI with disinclination to talk, difference of sleeping easily is waken up, anorexia loose stool, hypogalactia and clear, light red tongue, thready pulse, is diagnosed as both Qi and blood deficiency postpartum depression.Give Chinese medicine embodiment 1 capsule of the present invention, each 4, every day 3 times, give psychological consultation treatment simultaneously.After treating 6 weeks, clinical cure.Follow up a case by regular visits to and do not recur half a year.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (9)

1. treat a Chinese medicine for both Qi and blood deficiency postpartum depression, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Lignum Trachycarpi, fruits of Celastrus orbiculatus Thunb, Salvia miltiorrhiza Bge, Rhizoma Arisaematis, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) Rhizoma typhae, Radix Flemingiae Philippinensis, Flos Caraganae Sinicae, Ramulus et Folium Loranthi Pentapetali, Radix seu Caulis Verntilaginis Leiocarpae, Radix Polygalae fallacis, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk), Paphio-pedilum micranthum Tang et Wang, red palpus palpus, Upupa epops L., Oreas martiana (Hopp. Et Hornsch.) Brid. and Bridelia monoica (Lour.) Merr..
2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Lignum Trachycarpi 10 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 35 ~ 45 parts, Salvia miltiorrhiza Bge 5 ~ 15 parts, Rhizoma Arisaematis 10 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 10 ~ 25 parts, Rhizoma typhae 15 ~ 25 parts, Radix Flemingiae Philippinensis 15 ~ 25 parts, Flos Caraganae Sinicae 10 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 5 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 35 ~ 45 parts, Radix Polygalae fallacis 10 ~ 20 parts, 15 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 10 ~ 20 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 25 parts, red palpus palpus 10 ~ 25 parts, Upupa epops L. 10 ~ 20 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 15 ~ 25 parts and Bridelia monoica (Lour.) Merr. 35 ~ 45 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Lignum Trachycarpi 15 ~ 20 parts, fruits of Celastrus orbiculatus Thunb 40 ~ 45 parts, Salvia miltiorrhiza Bge 10 ~ 15 parts, Rhizoma Arisaematis 15 ~ 20 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 15 ~ 20 parts, Rhizoma typhae 15 ~ 20 parts, Radix Flemingiae Philippinensis 20 ~ 25 parts, Flos Caraganae Sinicae 15 ~ 20 parts, Ramulus et Folium Loranthi Pentapetali 10 ~ 15 parts, Radix seu Caulis Verntilaginis Leiocarpae 38 ~ 45 parts, Radix Polygalae fallacis 15 ~ 20 parts, 20 ~ 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 13 ~ 18 parts, Paphio-pedilum micranthum Tang et Wang 15 ~ 20 parts, red palpus palpus 14 ~ 22 parts, Upupa epops L. 10 ~ 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 ~ 25 parts and Bridelia monoica (Lour.) Merr. 38 ~ 45 parts.
4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Lignum Trachycarpi 16 parts, fruits of Celastrus orbiculatus Thunb 44 parts, Salvia miltiorrhiza Bge 12 parts, Rhizoma Arisaematis 18 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 17 parts of Rhizoma typhae 18 parts, Radix Flemingiae Philippinensis 20 parts, Flos Caraganae Sinicae 19 parts, Ramulus et Folium Loranthi Pentapetali 11 parts, Radix seu Caulis Verntilaginis Leiocarpae 39 parts, Radix Polygalae fallacis 19 parts, 23 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 15 parts, Paphio-pedilum micranthum Tang et Wang 16 parts, red palpus palpus 20 parts, Upupa epops L. 12 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 23 parts and Bridelia monoica (Lour.) Merr. 38 parts.
5. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Lignum Trachycarpi 19 parts, fruits of Celastrus orbiculatus Thunb 41 parts, Salvia miltiorrhiza Bge 15 parts, Rhizoma Arisaematis 15 parts, Cyperus michelianus(L.) Link (Herba Cyperi Micheliani) 20 parts of Rhizoma typhae 15 parts, Radix Flemingiae Philippinensis 23 parts, Flos Caraganae Sinicae 15 parts, Ramulus et Folium Loranthi Pentapetali 14 parts, Radix seu Caulis Verntilaginis Leiocarpae 42 parts, Radix Polygalae fallacis 16 parts, 25 parts, spun gold brush, Cratoneuron filicinum (Hedw.) Spruc.(Lolsk) 18 parts, Paphio-pedilum micranthum Tang et Wang 20 parts, red palpus palpus 15 parts, Upupa epops L. 15 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 18 parts and Bridelia monoica (Lour.) Merr. 43 parts.
6. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
7. the Chinese medicine as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
8. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
9. a preparation method for Chinese medicine described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
CN201510478079.3A 2015-08-06 2015-08-06 Traditional Chinese medicine for treatment of qi and blood deficiency type postpartum depression and preparation method thereof Pending CN105055761A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101322830A (en) * 2008-07-27 2008-12-17 麻爱华 Medicament for treating postpartum depression and preparation method thereof
CN104306797A (en) * 2014-11-21 2015-01-28 鹿树军 Traditional Chinese medicine combination for treating postnatal depression

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101322830A (en) * 2008-07-27 2008-12-17 麻爱华 Medicament for treating postpartum depression and preparation method thereof
CN104306797A (en) * 2014-11-21 2015-01-28 鹿树军 Traditional Chinese medicine combination for treating postnatal depression

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