CN103007234A

CN103007234A - Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation

Info

Publication number: CN103007234A
Application number: CN2012105832768A
Authority: CN
Inventors: 杨高林
Original assignee: Qingdao Huaren Information Technology Development Co Ltd
Priority date: 2012-12-28
Filing date: 2012-12-28
Publication date: 2013-04-03
Anticipated expiration: 2032-12-28
Also published as: CN103007234B

Abstract

The invention provides a traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis. The traditional Chinese medicine preparation comprises the following active ingredients in parts by weight: 10-20 parts of motherwort, 10-20 parts of white paeony root, 10-20 parts of raspberry, 10-20 parts of perilla stem, 10-20 parts of angelica, 10-20 parts of dogwood, 10-20 parts of polygala tenuifolia, 10-20 parts of dandelion, 10-20 parts of glossy privet fruit, 10-20 parts of prepared fleece flower root, 10-20 parts of bupleurum, 10-20 parts of shelled cedar seed, 10-20 parts of rhizome of chuanxiong, 10-20 parts of trogopterus dung, 10-20 parts of root of red-rooted salvia, 10-20 parts of fennel, 10-20 parts of rhizoma cyperi, 10-20 parts of poria with hostwood, 10-20 parts of bighead atractylodes rhizome, 10-20 parts of dried ginger and 10-20 parts of cortex albiziae. The traditional Chinese medicine preparation is on the basis of syndrome differentiation and treatment and has good clinical curative effects by taking liver regulating medicines for smoothing the liver, warming the liver, nourishing the liver, removing heat from the liver and the like as well as medicines for invigorating blood circulation and eliminating stasis.

Description

A kind of endometriosis for the treatment of causes Chinese medicine preparation of dysmenorrhea and preparation method thereof

Technical field

The present invention relates to contain the Chinese medicine that derives from plant, animal or mineral component, particularly a kind of endometriosis for the treatment of causes Chinese medicine preparation of dysmenorrhea and preparation method thereof.

Background technology

Endometriosis is common gynecological disease, and main manifestations is that carrying out property of dysmenorrhea Secondary cases increases the weight of, and sickness rate can reach 10%, 71%～87% endometriosis patients in Women of Childbearing Age chronic pelvic pain.Most scholars think, " stagnation of blood stasis uterus, punching are appointed " is the basic pathogenesis of endometriosis dysmenorrhea, and blood circulation promoting and blood stasis dispelling is the base therapy principle.Yet, the decoction for the treatment that alone drug for invigorating blood circulation and eliminating stasis is piled up, effect is also unsatisfactory.In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder are in close relations, adopt from the liver opinion when treatment and control, take determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the basis, add respectively simultaneously soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. and transfer the liver medicine using drug for invigorating blood circulation and eliminating stasis, clinically obtain good curative effect.

Dysmenorrhea is the modal a kind of disease of women, and its pathogenic factor mostly is when row, is subjected to the impact of various paathogenic factors, makes punching appoint QI-blood circulation not smooth, severe patient through stasis in uterus, collaterals of the uterus, consequently " stagnation of QI and blood may bring about pain "; Or deficient qi and blood, kidney qi loss cause the uterus lose in moistening foster, " not flourish and pain ".Sick position in the uterus, punching appoints, take " stagnation of QI and blood may bring about pain " or " Rong Ze pain " as main pathogenesis, clinical minute functional (claim not only constitutional) and organic (but also claiming Secondary cases).Often show stomachache and mostly occur at (1～2) d before tide, the 1d that passes through reaches the peak, can be clonospasm or distending pain companion bearing down, and severe patient can emit to lumbosacral region, anus, vagina, burst inboard.Even visible pale complexion, be in a cold sweat, hands and feet coolness etc. is fainted resembles.Also have minority in menses will be clean or after clean (1～2) d begin to feel and suffer from abdominal pain or waist stomachache person.In conjunction with physical examination, generally do not accompany tension of abdominal muscle or rebound tenderness, adolescence or many function of dominants of unpregnancy young woman person property dysmenorrhea; Child-bearing period or the motherhood history is arranged repeatedly and intrauterine surgical history companion pelvic cavity in adhesion, enclosed mass, tuberosity or the person of thickening are arranged, then belong to organic as due to the diseases such as pelvic inflammation, endometriosis more.Some patients were is visible body of uterus extreme flexing or cervix uteri stenostomy also.

" Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " pointed out: " the faint passages through which vital energy circulates of the moon of liver foot arises from the dorsal hairy region of the big toe ... cross external genitals, supports lower abdomen ... the diseases resulting from the disorder of this meridian lumbago with inability of bending forward and backward, husband Hui hernia, and married woman's lower abdominal pain, dry sensation in the pharynx very then, dusty face decolours." " Plain Questions lift pain opinion " also point out: " and the cold visitor in arteries and veins, blood tears swift pulse then, therefore costa sternales with lack abdomen phase dragging pain ".The cold coagulation Liver Channel, the passages through which vital energy circulates contracture, qi depression to blood stasis is the Etiological pathogenesis that causes endometriosis dysmenorrhea.Clinical manifestation such as lower abdomen contracture cold type of pain, aversion to cold and cold limbs, pale complexion.Many dispelling cold by warming the meridian medicines such as Fructus Foeniculi, Fructus Evodiae, Cortex Cinnamomi all enter Liver Channel and reach the effect of antalgic.The faint arteries and veins of the moon, the arteries and veins person of the moon of fainting, hernia and colic lies in liver, the liver failing to maintain the normal flow of QI, the syndrome that depression and stagnation of QI shows.How because of depressed emotion, or the invasion of unexpected direct stimulation and other pathogenic factor and falling ill.The liver failing to maintain the normal flow of QI, mechanism of qi pent-up, then depressed emotion; For a long time strongly fragrant not understanding lost its submissive happy property, therefore being irritable and getting angry easily.Production of phlegm due to stagnation of QI, phlegm rising following QI is fought to tie in pharynx and is then seen globus hystericus, and accumulate in neck and then be goiter, qi disease involving blood, qi depression to blood stasis, therefore disharmony of Chong and Conception Channels is menoxenia or abdominal pain during menstruation.Gas gathers blood agglomeration, with the passing of time becomes the Guo abdominal mass to gather.Control suitable dispersing the stagnated live-QI to relieve the stagnation of QI, be equipped with in case of necessity the methods such as activating QI to eliminate phlegm, movable blood soft hard.

Liver controlling conveyance and dispersion has the function of emotion regulation, syndrome of stagnation of liver qi, and general depressed emotion, feeling of distension and oppression pain occurs in position that Liver Channel is crossed, and the vexed pain of altering of the breast side of body or few abdominal distention is uncomfortable in chest, sighing frequently, depressed emotion irritability, or foreign body in pharynx sense, or cervical region goiter, or the lower lump of the side of body.The visible following symptom of women: 1. depression of liver-QI causes constrains, worry often causes that the women has a headache, agitation, anxious state of mind irritability, distending pain in the chest and hypochondrium, abdominal part distension, endocrine regulation.Woman's eumenorrhea whether normally whether closely related with the catharsis function of liver, irritability is not dredged and can be caused too short, Hypomenorrhea, intermenstrual bleeding, dizziness during menstruation of menstrual period, be insomnia through row.3. Liver Channel follows row at two sides of body, and the operation of Liver Channel arteries and veins freely also may not cause the generation of cyclomastopathy, breast nodule even breast carcinoma.4. stagnation of liver-QI causes insomnia, shows as to have difficulty in going to sleep, even sleeping also dreaming often and waking easily.Can't guarantee sleep quality, make femininity blood cervical carcinoma with cachexia, pachylosis, face is obscure.Wherein liver depression forming fire type aypnia is many because of angry impairing the liver.

In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder are in close relations, adopt from the liver opinion in when treatment and to control, take determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the basis, add respectively simultaneously soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. and transfer the liver medicine using drug for invigorating blood circulation and eliminating stasis, clinically obtain good curative effect, reconcile temperament and interest, relieving dysmenorrhea, dispersing the stagnated live-QI to relieve the stagnation of QI are reasonable selections, generally being free from side effects, is very safe.

Medicine just under study for action comprises leukotriene inhibitors and vasopressin.Randomized control study confirms that beginning first three day in dysmenorrhea uses vasopressin with respect to the effective relieving dysmenorrhea of placebo.Arachidonic acid is the precursor of synthesis of prostaglandins, so low fat diet (comprise the absorption that reduces salmon fish, tuna, beans, Semen Sesami, sunflower seed etc., increase the absorption of whole wheat, vegetable and fruit).Oral vitamin E and B1, magnesium sulfate, fish oil, low fat diet and Chinese medicine Toki-shakuyaku-san (TSS) but equal relieving dysmenorrheas, but these sources of evidence are studied in small-scale nonrandomness.Data about exercise are limited, but think that it is effective.Local heat, acupuncture and transcutaneous electrical neural stimulation (TENS).Result of study thinks that the blood-activating stasis-removing kind Chinese medicine also may be effectively.The effect of spinal manipulation is still treated further to determine.The Chinese medicine preparation often can be difficult to the ill medication, and specific aim is not strong, and therapeutic effect is general; Therefore seek safety, effectively, comprehensive dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, relieving dysmenorrhea, be the important topic of pendulum in face of vast medical research worker it

Summary of the invention

Technical problem to be solved by this invention is, at present the conventional way of relieving dysmenorrhea be oral vitamin E and B1, magnesium sulfate, fish oil, low fat diet and Chinese medicine Toki-shakuyaku-san (TSS) but equal relieving dysmenorrheas, but these sources of evidence are studied in small-scale nonrandomness.Endometriosis dysmenorrhea and Liver Channel functional disorder are in close relations, when treatment, adopt from the liver opinion and control, take determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the basis, add respectively simultaneously soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. and transfer the liver medicine using drug for invigorating blood circulation and eliminating stasis, clinically obtain good curative effect Chinese medicine preparation, often can be difficult to the ill medication, and specific aim is not strong, therapeutic effect is general.

For solving these technical barriers, the invention provides a kind of Chinese medicine preparation that endometriosis causes dysmenorrhea for the treatment of, the parts by weight of various raw materials comprise in the described Chinese medicine preparation: 10～20 parts of Herba Leonuris, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Rubies, 10～20 parts of Caulis Perillaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Polygalaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Bupleuri, 10～20 parts of Semen Platycladi, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Foeniculi, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Poria cum Radix Pinis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Zingiberiss, 10～20 parts of Cortex Albiziaes.

Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, the parts by weight of various raw materials can be preferably in its described Chinese medicine preparation: 10～15 parts of Herba Leonuris, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Rubies, 10～15 parts of Caulis Perillaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Polygalaes, 10～15 parts of Herba Taraxacis, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Bupleuri, 10～20 parts of Semen Platycladi, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Foeniculi, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Poria cum Radix Pinis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Zingiberiss, 10～20 parts of Cortex Albiziaes.

Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, the parts by weight of various raw materials can also be preferably in its described Chinese medicine preparation: 10～20 parts of Herba Leonuris, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Rubies, 10～20 parts of Caulis Perillaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Polygalaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Bupleuri, 10～15 parts of Semen Platycladi, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Fructus Foeniculi, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Poria cum Radix Pinis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Rhizoma Zingiberiss, 10～15 parts of Cortex Albiziaes.

Described dispersing the stagnated live-QI to relieve the stagnation of QI, the Chinese medicine preparation of relieving dysmenorrhea, its described Chinese medicine preparation dosage form can for: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine preparation, and when described preparation formulation was oral solutions, preparation method comprised:

A, get raw material and put into ethanol and soak, heat is extracted 2 times, becomes paste, is component 1;

B, medicinal residues water extraction 2 times, thickening filtration are paste, are component 2;

C, above-mentioned two kinds of pastes are condensed into pasty state, sterilization adds dextrin, then vacuum freezing sealing.

Among the described step a, can get crude drug adds in the ethanol that 5-10 doubly measures and soaked heating extraction 2 times, each 1-2 hour 1-2 hour, remove supernatant, merge extractive liquid,, the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use becomes component 1.

Among the described step b, the medicinal residues that ethanol extraction can be crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use becomes component 2.

Among the described step c, above-mentioned two kinds of component pastes can be condensed into pasty state, concentrated solution is sterilized with CO60, and irradiation dose 8k adds dextrin, and then vacuum canning sealing and get final product is directly drunk during use.

For solving the problems of the technologies described above, the present invention provides a kind of preparation method preparation method of Chinese medicine preparation again, and described preparation formulation is that the preparation method of capsule comprises:

A. described raw material is put into the pulverizer grinding and sieving;

B. the rear remaining particulate matter that will sieve is put into the ethanol heating and refluxing extraction 2 times;

C. get again the medicinal residues behind the above-mentioned ethanol extraction, add the water heating and refluxing extraction 1 time;

D. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol and spray drying get medicated powder; The fine powder that mixing sieves obtains incapsulates and is made as capsule.

Among the described step a, described raw material can be put into and cross 120 order dusting covers after pulverizer is pulverized, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; Among the described step b, the rear remaining particulate matter that sieves can be put into the ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging be left standstill; Among the described step c, the medicinal residues that above-mentioned ethanol extraction is crossed can be added 1～2 hour reflux, extract, of 10 times of water gagings heating 1 time; Above-mentioned 3 extracting solution merging is left standstill; In the described steps d, said extracted liquid can be merged, 1.08 filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol, gained filtrate is adjusted proportion to 1.06, pass into spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m2, the hothouse hot stream temperature is 80 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving and ethanol are refined medicated powder to be mixed and incapsulates.

Preparation of the present invention is dispersing the stagnated live-QI to relieve the stagnation of QI, the reply women is because the dysmenorrhea that endometriosis causes, has liver and kidney tonifying, the calm the nerves effect of merit of nourishing YIN for decreasing fever, relieving restlessness, thereby elimination dysmenorrhea, the easy dry irritability of disposition, spontaneous sweating occurs frequently, insomnia and dreamful sleep, vertigo and tinnitus, dysphoria unstable blood pressure etc. is levied successful.Select again drug matching, regulating plant function of nervous system reduces the incretion balance obstacle, improves the psychataxia symptom, keeps homergy, and all medicine compatibilities are played the kidney warming tonifying YIN altogether, the merit of adjusting and runing yang.In conjunction with clinical practice, endometriosis dysmenorrhea and Liver Channel functional disorder are in close relations, adopt from the liver opinion when treatment and control, take determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs as the basis, add respectively simultaneously soothing the liver, warming the liver, nourishing the liver, liver heat removing etc. and transfer the liver medicine using drug for invigorating blood circulation and eliminating stasis, clinically obtain good curative effect.

The specific embodiment

There is no endometriosis name of disease record in the Chinese medicine ancient books, according to the endometriosis clinical manifestation, can belong to dysmenorrhea, mass in the abdomen, menoxenia, the category such as infertile.Pathogeny to dysmenorrhea has numerous discussions, and the main and heart, liver, kidney three dirty close relations are wherein especially close with liver.Modern medicine is observed endometriosis can cause various variety classeses, pain in various degree, the pain etc. that comprises dysmenorrhea, sexual anhedonia, defecation pain, chronic pelvic pain, low-back pain and be radiated to part internal organs and limbs widely distributedly distributes perfectly in harmony with Liver Channel." Medical Treasures of the Golden Chamber abdominal distention colic of cold type dyspepsia abnormal pulse card is controlled " cloud: " pulse at CUN KOU being stringy person, then contraction and pain in the hypochondrium." the many strings of pain arteries and veins, stringy pulse belongs to liver, liver governing tendons, and it is also relevant with liver that the uterus is spasm shape contraction person.Illustrate that dysmenorrhea and liver are in close relations.The woman is take liver as congenital, and the conditioning liver makes its catharsis function normal, and then store blood is devoted to one's duty, abundant CHONG meridian with unobstructed REN meridian, and QI and blood is in harmonious proportion, from the reason of painless warp.Our research is thought and is controlled endometriosis dysmenorrhea as the main rule for the treatment of from liver opinion, is significant to improving curative effect.

What dream precious jade " doctor's rock " of the Qing Dynasty carries: " all kinds of diseases and ailments are born in strongly fragrant, and are strongly fragrant and do not dredge, then diseases of edema with the liver involved all." woman's physiological cycle QI and blood easily fluctuates, feelings will is easy to melancholy, the pent-up of feelings will, and depression of liver-QI, the liver failing to maintain the normal flow of QI causes depression and stagnation of QI, and QI and blood is tied mutually, and blood fortune is not smooth, and a vessels of the uterus stasis blocking generation dysmenorrhea is appointed in punching.The essence of endometriosis dysmenorrhea is blood stasis, and key then is gas." qi being the governor of blood, blood being the material foundation of QI ", the interdependent and mutually promoting on physiology of gas and blood, interactional relation on the pathology, final decision in the treatment of endometriosis dysmenorrhea in uterus of dispersing the stagnated live-QI to relieve the stagnation of QI method irreplaceable effect is arranged.Control when soothing the liver promoting QI circulation for relieving depression, the liver controlling conveyance and dispersion function is normal, and then QI and blood is in harmonious proportion, and smooth through working, general rule is not bitterly.Control suitable dispersing the stagnated live-QI to relieve the stagnation of QI, be equipped with in case of necessity the methods such as activating QI to eliminate phlegm, movable blood soft hard.Before and after disconnected, Radix Semiaquilegiae gradually exhausts, kidney water dries up, edema with the liver involved is lost and is supported, the hepatic and renal YIN deficiency causes pre-postmenstrual syndromes, the pathogenesis side of sending accordingly, in the side with the merit of the Radix Paeoniae Alba with its nourishing blood for regulating menstruation, suppressing the hyperactive liver pain relieving, astringing YIN to stop sweating, with separate blood deficiency, the deficiency of YIN has the thermic menoxenia, the cards such as deficiecny of liver-YIN causes that headache is dizzy, rib side of body pain and night sweat due to yin deficiency; Fructus Ligustri Lucidi has the effect of tonifying liver kidney yin, clearing away heat to improve acuity of vision, except soreness of waist and knee joint, and yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, the numbness of having a dizzy spell etc.; The Radix Salviae Miltiorrhizae heat clearing and damp drying, eliminating fire and detoxication is brought down a fever except steaming, and separates the deficiency of YIN and causes cards such as warming sweating, dysphoria with feverish sensation in the chest palms and soles.The Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, Semen Cuscutae, Radix Polygoni Multiflori Preparata liver and kidney tonifying, nourishing YIN for decreasing fever, Semen Platycladi, Radix Polygalae, Fructus Foeniculi are put forward the effect that positive relieving restlessness is calmed the nerves, and all medicine compatibilities have clearing heat and relieving fidgetness, the kidney invigorating and essence nourishing, benefiting QI for activating blood circulation, bone strengthening is mended marrow, eliminates forgetful insomnia, soreness of waist and knee joint, dizziness and tinnitus, xerostomia just difficult; The effect of menoxenia.

The Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, dispel silt, regulating menstruation, water disappears.The treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, rushes down blood, the carbuncle skin infection at hematuria.Herba Leonuri contains the materials such as leonurine, Fumaric acid, and the effects such as promoting blood flow to regulate menstruation, blood pressure lowering, inducing diuresis to remove edema are arranged.

Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.Be used for enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, and then body is sent out not in vain not also from light.The respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.Zhen Quan master man kidney-jing deficiency exhausts, impotence, woman's food son arranged.Large bright main settling five organs, beneficial color is supported vital essence, long hair, strong will.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food son arranged.Main impotence."

The flat sweet in the mouth of Semen Platycladi, the heart, kidney, large intestine channel.The effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Be used for restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicineization justice ": Semen Platycladi, the saturating heart of fragrance, the body profit is grown blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis for clear product in turbid, cure mainly mind void timid, the palpitation with fear severe palpitation, and color is wan and sallow, the skin pruritus due to dryness, the merit of the blood that all nourishes heart is also.Get again abnormal smells from the patient all dense, return kidney in turbid, same Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae for packing bone marrow, cure mainly damage of kidney-YIN, the back severe disease, and sufficient knee joint is weak, night sweat due to yin deficiency, all the dry power of nourishing kidney is also.Sweet in the mouth also can delay liver, and the deficiency of tonifying liver gallbladder is extremely reliable, but the flat power of property is slow, should be multiplex be wonderful.

Radix Polygalae is bitter, hot, tepor.GUIXIN, kidney, lung meridian.Function cures mainly the Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm detumescence.Be used for the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.Be applied to insomnia and dreamful sleep, severe palpitation, forgetful.This product toil is warm in nature, property is kind lead off sensible, happily gas and mind tranquilizing and the heart calming, can lead to kidney qi and strong will is not forgotten, be the by force good merchantable brand of knowledge of restoring normal coordination between the heart and kidney, stable mind, Fructus Alpiniae Oxyphyllae.Cure mainly the diseases such as malaise, insomnia, palpitation with fear of disarmony between the heart and kidney, normal and the same usefulness of medicinal for tranquilizing mind such as Poria cum Radix Pini, Dens Draconis, Cinnabaris are such as Radix Polygalae ball (" the Zhang Shi doctor is led to "); Control forgetful card, normal and Radix Ginseng, Poria, the same usefulness of Rhizoma Acori Graminei such as Kaixin San (" prescriptions worth thousand gold "), if Fang Zhongzai adds Poria cum Radix Pini, are not namely forgotten fall apart (" Standards of Diagnosis and Treatment ")." book on Chinese herbal medicine is just ": Radix Polygalae, the wholwe-hearted kidney of merit, therefore but the relieving palpitation spasmolytic, the peace that exorcises evil spirits dream, Yang strengthening and life essence tonifying, strong will power-assisted.With its gas lift, therefore same Radix Ginseng, Radix Glycyrrhizae, Semen Ziziphi Spinosae, the utmost point can be lifted and fall into consolidating semen, handing-over extreme misery.

The Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata minute, direct slicing is used as medicine and is Radix Polygoni Multiflori, mixes to dry to be used as medicine after the steaming with the Semen sojae atricolor liquor to be Radix Polygoni Multiflori Preparata.The function of the two is different: the detoxifcation of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation are usually used in treating scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening are used for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.

Fructus Ligustri Lucidi is used for the poor vision of the hepatic and renal YIN deficiency, visual deterioration, early whitening of beard and hair, soreness of waist tinnitus and fever due to yin deficiency etc.This product energy tonifying liver kidney yin, but the efficacy of a drug is gentle, must slowly get effect.Control poor vision, often join Radix Rehmanniae Preparata, Fructus Lycii is equal to usefulness, controls early whitening of beard and hair, often joins the same usefulness of Fructus Mori, and Cortex Lycii is often joined in fever due to yin deficiency.The hepatic and renal YIN deficiency, Light-headedness, seminal emission tinnitus, soreness of the waist and knees, early whitening of beard and hair, coronary heart disease, hyperlipemia, hypertension, chronic hepatitis.Protective effect research to liver is thought, Fructus Ligustri Lucidi contains oleanolic acid, give rat skin lower injection, can reduce serum glutamic pyruvic transminase, hepatic injury to Carbon Tetrachloride Induced has obvious protective effect, and can promote liver cell regeneration. and oleanolic acid also can make in the liver triglyceride accumulate that minimizings, hepatocellular degeneration necrosis obviously alleviate, glycogen is accumulated increase, serum γglobulin decline; Mitochondrial swelling and the degeneration of endoplasmic reticulum vesicle alleviates, the matter inflammatory reaction weakens between hepatic tissue in the visible hepatocyte of ultrastructure.

The Radix Paeoniae Alba enters liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and antenatal rear all diseases, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Fructus Corni cures mainly pathogen cold and heat under the heart, and warming middle-JIAO by cold warm numbness, goes three worms, for a long time made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, the merit of dribbling urination only of clothes; For a long time clothes make eye bright, brute force all the year round.Fructus Corni has another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., is China's rare Chinese medicine commonly used, and applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay the evil special efficacy that waits by successive dynasties usefulness that medical science is liked.Zhang Zhongjing has been formulated " JINGUI SHENQI WAN " take Fructus Corni as monarch.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibiotic, is the Herba indigoferae Pseudotinctoriae of commonly using in the tcm clinical practice.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, the lump in the abdomen caking, skin infection swells and ache, tumbling down is grieved, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect.. " detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae is loose, cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.The Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves effects such as circulating, remove intravascular coagulation, has the effect of invigorating blood circulation trace, and can promote the liver blood circulation to be beneficial to liver cell regeneration.

The hot little hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: the resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.Be used for stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type stomachache, distending pain of the breast." detailed outline " carries it: the cold epidemic disease of loose seasonal epidemic pathogens, and sharp three warmers are separated six kinds of stagnation-syndromes, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi is ended trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood, hematochezia, hematuria, married woman's bleeding not during menses, month time is uncomfortable, tire all kinds of diseases and ailments in front puerperal.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, really the gas medicine in the blood, the also panacea in the blood.About mending to mend then of assistant, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, therefore the pain relieving constipation of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can fall apart greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore want its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

The Caulis Perillae Caulis Perillae is a kind of Chinese medicine title.This product is the dry stem of labiate Folium Perillae Perillafrutescens (L.) Britt..Tap behind the fruit maturation autumn, removes impurity, dries, or take advantage of fresh slices, dries.Meridian distribution of property and flavor: suffering, temperature.Return lung, spleen channel.Function cures mainly: regulating the flow of QI to ease the stomach, and pain relieving, antiabortive.Be used for the chest and diaphragm painful abdominal mass vexed, gastralgia, belch vomiting, frequent fetal movement." book on Chinese herbal medicine is high former ": " saliva reduces phlegm for main alleviating distention in middle-JIAO circulation of qi promoting, the diet that disappears.Control dysphagia and regurgitation, end cardiac and abdominal pain."

Contain the multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in the Herba Taraxaci plant, the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting are arranged.Herba Taraxaci contains protein, fat, carbohydrate, trace element and vitamin etc. simultaneously, and abundant nutritive value is arranged, and is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.The Dandelion Compositae belongs to herbaceos perennial.It is the plant of dietotherapeutic.According to the Compendium of Material Medica record, the flat sweet and slightly bitter taste of its property has heat-clearing and toxic substances removing, dispersing swelling and dissipating binds and galgctogogue action, and is very effective to the treatment mastitis.No matter fry in shallow oil juice oral, or the smash to mud external application, effect is all arranged.In addition, Herba Taraxaci also has the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting, is widely used in clinical.Compendium of Material Medica has a cloud: " the tender Seedling of Herba Taraxaci is edible, eats that to control infectious disease especially good raw." the successive dynasties Medical monographs such as Shennong's Herbal, Tang Materia Medica, " Chinese medicine voluminous dictionary " all give high evaluation.

Radix Bupleuri clearind deficient heat Chinese medicine is used for that cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterus come off, menoxenia.Radix Bupleuri begins to be stated from Shennong's Herbal, classifies as top grade.The successive dynasties book on Chinese herbal medicine has record to the phytomorph of Radix Bupleuri more." book on Chinese herbal medicine is just ": " Radix Bupleuri, cool loose with it with this person, the heat of suppressing the hyperactive liver.It is cool in nature, thus separate alternate attack of chill and fever, flesh table hectic fever, the liver and gall fire is scorching, the chest and hypochondrium knot, the double skin infection of controlling, the blood chamber is heated; Its property is loose, therefore main typhoid fever pathogenic heat are not separated epidemic febrile disease intenseness of heat, SHAO YANG headache, Liver Channel melancholia.

Oletum Trogopterori is the dry feces of trogopterus xanthipes Milne-Edwards, can be used for the hemorrhage of blood-stasis internal-depression, escape of blood from meridian, and is many such as the woman uterine bleeding warp, the purple polylith of color, stabbing pain of the lower abdomen.Both but single was fried and was ground into powder, and heat wine takes, and can be used in conjunction with other drug again.Promoting blood circulation to remove blood stasis, the parch to black hemostasis.Be used for trusted subordinate's congestion and have a pain, dysmenorrhea, the blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black is controlled metrostaxis; Traumatic injury is controlled in external, and Serpentis, insect bite are hindered.It is logical that the Oletum Trogopterori hardship is let out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." " the stasis passages through which vital energy circulates, gas must not be gone, and attacks the cards such as thorn pain, must use therefore " Bencao Jingshu " calls it.”

The contained main component of Fructus Foeniculi all is Oleum Anisi Stellati, energy stimulating gastrointestinal neural blood vessel, and the secretion of facilitating digestion liquid increases gastrointestinal peristalsis, gets rid of the gas that accumulates, so the effect of stomach invigorating, circulation of qi promoting is arranged; Sometimes gastrointestinal peristalsis can reduce again after excitement, thereby helps to alleviate spasm, eases the pain.Be used as medicine on the Chinese medicine, warm in nature, acrid in the mouth is returned liver,kidney,spleen, stomach warp.Function warming the liver kidney, warming the stomach gas, loose plug knot, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach.Be used for colic of cold type stomachache, the testis swelling and hanging down of either of the testes, dysmenorrhes, few abdomen cold type of pain, abdominal distention, the diseases such as lack of appetite and vomiting.

Poria cum Radix Pini is the sclerotium of the sleeping hole platymiscium Poria [(Poria cocos Schw.) Wolf] of Polyporaceae, and former species are rudimentary plant, are the funguses that colonizes on the pinaster.Medicinal part is the dry sclerotia body.Nature and flavor are sweet, light flat.The functions such as eliminating dampness by diuresis, spleen invigorating, mind calming are arranged.Be used for phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.Cortex Sclerotii Poriae, inducing diuresis to remove edema is used for the diseases such as the wet edema of water." property of medicine opinion ": main infantile convulsion, tranquilizing the mind is mended tired; Main acute pain in the epigastrium is hard full, and small intestinal is unfavorable.Poria cum Radix Pini is the Chinese medicine product of plant Poria, and former plant multiparasitization is on Pinus massoniana Lamb or Duan Mu, and its growth promoter can be divided into two stages: i.e. mycelia (white filament) stage and sclerotium stage.Vegetative stage mainly is mycelia absorbs moisture and nutrition from wood surface, and secretase decomposes and transforms organic matter (cellulose) in the timber simultaneously, makes mycelia spread over vigorous growth in the timber.Second stage is that mycelia is coalescent agglomerating to middle and late stage, forms gradually sclerotium (also claiming knot etc.).Knot Siberian cocklebur size has substantial connection with quality, nutritional condition and the envirment factors such as temperature, humidity of strain.The strain of different cultivars, the time length of knot Siberian cocklebur is also different, and 3～4 months began to tie Siberian cocklebur after some kinds were planted, and some is then slower, needs 6～7 months.Can gather in the crops in 9～10 months after early seasonal strain is planted, late-maturing kind then needs 12～14 months.The common person of Poria cum Radix Pini is its sclerote.Mostly be irregular bulk, sphere, flat, Long Circle or oblong etc., not of uniform size, little person such as fist, large person's diameter reaches 20～30 centimetres, or larger.The light taupe brown of epidermis or pitchy are the warty shrinkage, and inner white slightly is with pink, are comprised of countless mycelia.The sporophore umbrella shape, 0.5～2 millimeter of diameter, peristoma slightly has tooth; Sexual generation is difficult for seeing, and is cellular, the crust of common attached sclerotium and giving birth to, first white, after change gradually light brown into, polygon is made in the hole, load is bar-shaped, basidiospore is oval to cylindrical, flexing slightly, end point, level and smooth, colourless, special foul smell is arranged.

The Rhizoma Zingiberis acrid in the mouth, hot in nature.Return spleen, stomach, the heart, lung meridian.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.Coldness and pain in the epigastrium; Vomiting; Have loose bowels, YANG-depletion is fainted contrary; Cold fluid-retention is breathed with cough; Arthralgia due to cold-dampnes." not Lu ": " control abdominal pain due to cold, attacked by pestiferous factors, cholera, distension, all poison of ailment said due to cold or exposure, stagnation of QI between skin ends hemoptysis.”

Rhizoma Chuanxiong is hot, temperature.Return liver, gallbladder, pericardium channel.The function blood-activating and qi-promoting, wind-expelling pain-stopping.Be used for menoxenia, amenorrhea dysmenorrhea, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, and the effect of activating blood cirulation to regulate QI flow is arranged.

Cortex Albiziae: nature and flavor are sweet, flat.The merit that resolving depression and blood, mind calming, subduing inflammation are arranged.The effect that the irritability of controlling, melancholy, insomnia, lung abscess, carbuncle, scrofula, muscle fracture wound are arranged.Antifertility action Cortex Albiziae cold water extract has significant antifertility action, and the amniotic membrane intracavitary administration can make the young atrophy of middle pregnant rat tire, the pale and interruption of pregnancy of color and luster.People's gravid uterus bar is under the effect of Cortex Albiziae extracting solution, and shrink tension and amplitude all significantly increase, and contraction frequency then obviously reduces, and the effect of Cortex Albiziae is similar to oxytocin, but onset time is slower, longer duration.Cortex Albiziae antifertility effective ingredient is Saponin, and the total Saponin 1.78mg/kg of Cortex Albiziae subcutaneous injection has remarkable Antiimplantation Action, can reduce Rat Pregnancy number of animals and fetal tissues number, and the termination of pregnancy rate is 86%.In gestation administration on the 4th～6 remarkable interceptive effect is arranged also, the termination of pregnancy rate is 40%.The injection of Cortex Albiziae general glycoside official jargon can make gestation rat afterbirth atrophy on the 6th～7 dead, and mortality rate is 88%.70 μ g/kg lumbar injections (l/50 of mice LD50), every day 1 time, totally 3 days, can not make female Mus uterus weight childhood, show that its no estrogen sample is active.The bark of the multiple congener of Herba Albiziae all has significant excited uterus and causes Induction of abortion, as principal columns of a hall tree (A, chinensis) contained triterpenoid saponin in gestation during each administration all can cause the animal miscarriage, there is significant excitation in arteries and veins Mus or people's uterus.The contained Saponin of Alibizia Kalkora (Roxb.) Prain (A, kalkora) bark also has the effects such as anti-implantation and antiearly pregnancy to rat.

The manufacturing process of the present invention's honey refining pill is: get Herba Leonuri 1000, Radix Paeoniae Alba 1000g, Fructus Rubi 1000g, Caulis Perillae 1000g, Radix Angelicae Sinensis 1000g, Fructus Corni 1000g, Herba Ecliptae 1000g, Radix Polygalae 1000g, Herba Taraxaci 1000g, Placenta Hominis 1000g, Fructus Ligustri Lucidi 1000g, Radix Polygoni Multiflori Preparata 1000g, Semen Cuscutae 1000g, Radix Bupleuri 1000g, Semen Platycladi 1000g, Rhizoma Chuanxiong 1000g, Oletum Trogopterori 1000g, vinegar Pericarpium Citri Reticulatae 1000g, Radix Salviae Miltiorrhizae 1000g, Fructus Foeniculi 1000g, Rhizoma Cyperi 1000g, Poria cum Radix Pini 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Rhizoma Zingiberis 1000g, Cortex Albiziae 1000g, get described crude drug and be soaked in the 70%-80% ethanol, heating and refluxing extraction three times, 1.5 hours time, 1 hour, 1 hour, merge extractive liquid, filters filtrate recycling ethanol, be concentrated into driedly, in 60 ℃ of lower vacuum dryings, take out, pulverize, cross 100 mesh sieves, fine powder is for subsequent use; Add Mel and make honey refining pill.

The manufacturing process of capsule of the present invention is: get Herba Leonuri 1100, Radix Paeoniae Alba 1200g, Fructus Rubi 1300g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1300g, Fructus Corni 1200g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1300g, Radix Bupleuri 1400g, Semen Platycladi 1200g, Rhizoma Chuanxiong 1100g, Oletum Trogopterori 1300g, Radix Salviae Miltiorrhizae 1300g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1100g, Poria cum Radix Pini 1200g, Rhizoma Atractylodis Macrocephalae 1400g, Rhizoma Zingiberis 1200g, Cortex Albiziae 1200g, add heating extraction 2 times in 10 times of amount ethanol, each 1～2 hour, 2 extracting solution are merged leave standstill; The medicinal residues of the component raw medicinal material that above-mentioned ethanol extraction is crossed add 10 times of water gaging heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution are merged leave standstill.Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol and to be concentrated into liquor strength be 0.6g crude drug/mL is behind the sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃ is put into oven drying and obtained component medicated powder, incapsulates and is made as capsule.Every capsules dress 0.3g.Can per 12 be one edition.

The manufacturing process of oral solutions of the present invention is: get Herba Leonuri 1300, Radix Paeoniae Alba 1100g, Fructus Rubi 1400g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1300g, Fructus Corni 1400g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1300g, Radix Bupleuri 1400g, Semen Platycladi 1400g, Rhizoma Chuanxiong 1200g, Oletum Trogopterori 1400g, Radix Salviae Miltiorrhizae 1100g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1200g, Poria cum Radix Pini 1200g, Rhizoma Atractylodis Macrocephalae 1300g, Rhizoma Zingiberis 1400g, Cortex Albiziae 1300g, get crude drug and added soak with ethanol 1-2 hour that 5-10 doubly measures, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid,, the 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating is concentrated into the extractum shape, stand for standby use becomes component 1; The medicinal residues that water extraction is crossed are put into 10 times of water gagings, heating and refluxing extraction 1 time, extraction time is 1～2 hour, the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams again, 1.38 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, concentrated 30 minutes～45 minutes of heating, be concentrated into the extractum shape, stand for standby use becomes component 2.Above-mentioned two kinds of extractum are condensed into pasty state, and concentrated solution is with CO 60 sterilization, and irradiation dose 8k adds dextrin, then vacuum canning sealing and get final product.

Powder preparation process of the present invention is: get Herba Leonuri 1200g, Radix Paeoniae Alba 1500g, Fructus Rubi 1200g, Caulis Perillae 1200g, Radix Angelicae Sinensis 1400g, Fructus Corni 1400g, Radix Polygalae 1300g, Herba Taraxaci 1400g, Fructus Ligustri Lucidi 1100g, Radix Polygoni Multiflori Preparata 1500g, Radix Bupleuri 1400g, Semen Platycladi 1400g, Rhizoma Chuanxiong 1200g, Oletum Trogopterori 1400g Radix Salviae Miltiorrhizae 1100g, Fructus Foeniculi 1300g, Rhizoma Cyperi 1400g, Poria cum Radix Pini 1400g, Rhizoma Atractylodis Macrocephalae 1300g, Rhizoma Zingiberis 1400g, Cortex Albiziae 1300g, medical material was soaked 30 minutes to 1 hour, heated and boiled 30～40 minutes is filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 30～40 minutes for the third time, filters; Three filtrates are combined, and heating is concentrated into the pasty state medicinal liquid, puts into baking oven 80 degree oven dry to Powdered.

Pharmacology's toxicity test

1, acute toxicity test

The application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of mice oral administration gavage, under 488.8g crude drug/kg dosage, the light activity minimizing appears in mice after the administration, recover normal about 1 hour, Continuous Observation is 7 days after the administration, none animal dead, its overall health of patients, diet, to take the photograph water, urine and body weight gain all normal, and experimental result shows: the maximum dosage-feeding of mice oral administration gavage preparation capsule of the present invention is 488.8g crude drug/kg/d (LD 50＞488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; Press weighing machine, the dosis tolerata of mouse stomach preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select the SD rat, give variable concentrations (18.0,6.0, the Chinese medicine preparation granule of the present invention of 2.0g crude drug/kg), every day gavage once, continuous 90 days, 24 hours each groups are lived and are killed 1/2 animal (male and female half and half) after the last administration, live extremely after all the other 1/2 animals continuation observed for 2 weeks.Duration of test is observed outward appearance, general behavior, food ration, the body weight change of animal, after the administration 90 days and carry out hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) in 2 weeks of drug withdrawal and the index checkings such as blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology.Result of the test shows: preparation of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight gain all change without unusual; Three dosage groups and matched group hematological examination, blood biochemical are learned, the urine biochemical analysis is all in normal range, between group without significant difference; Each is organized the main organs histopathological examination and shows no obvious abnormalities.The These parameters drug withdrawal also has no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, according to result of the test Chinese medicine preparation of the present invention high, medium and low three dosage (18.0,6.0, the 2.0g crude drug/kg) administration in continuous 90 days has no significant effect rat, without clear and definite toxicity target organ and sensitive indicator, the convalescent period observation also has no the retardance toxic reaction, points out the dosage safety of Chinese medicine preparation clinical practice of the present invention higher.

The pharmacological experiment explanation:

1 data and method

1.1 physical data: choose my institute's department of Chinese medicine and outpatients of gynecology 96 examples.With consultation time successively with the patient according to A/B circular order random packet, the A group is included treatment group in, the B group is included matched group in.Treatment group 48 examples, 15～30 years old age, average 20.3 years old; The course of disease 3 months～7 years, average 3.03.The dysmenorrhea grading: light, in, severe person is respectively 6 examples, 28 examples, 14 examples.Matched group 48 examples, 16～29 years old age, average 19.8 years old; The course of disease 5 months～7 years, average 3.04.The dysmenorrhea grading: light, in, severe person is respectively 7 examples, 26 examples, 15 examples.All through in detail gynecological clinic inspection, the result is endometriosis, and other show no obvious abnormalities.The factor difference not statistically significants (P＞0.05) such as two groups of patient ages, the course of disease, the state of an illness have comparability.

1.2 diagnostic criteria: draft diagnostic criteria with reference to " traditional Chinese medical science disease Standardization of diagnosis and curative effect " of State Administration of Traditional Chinese Medicine issue as follows: menstrual period or before and after row lower abdomen pain, pain and waist sacrum are very then fainted; Be periodical attack; And the stomachache due to the eliminating organic disease.

1.3 inclusive criteria: meet diagnostic criteria, at 15～30 years old age, the other treatment of being ready to stop using is accepted this therapy and is finished 3 menstrual cycle therapists.

1.4 exclusion standard: the gynaecopathia that is caused by genitals's organic disease such as pelvic inflammatory disease, adenomyosis, hysteromyoma etc.; Intrauterine is placed birth control apparatus (being commonly called as intrauterine device); Be associated with the serious life-threatening primary disease patients such as cardiovascular and cerebrovascular vessel and disease of hematopoietic system; The organ function injury persons such as Liver and kidney; Mental sickness, acute infectious disease, tumor patient; Get rid of and accepted other relevant treatments, can affect this research effect index observer.

1.5 Therapeutic Method: matched group is with the ibuprofen modified release capsule oral medication, and treatment group Chinese medicine preparation of the present invention is treated.Matched group is oral with ibuprofen modified release capsule (ibuprofen, Sino-America Tianjin Shike Pharmaceutical Co., Ltd. produces) 0.3g, and 1 time/d, the severe pain person can 2 times/d.When dysmenorrhea, begin to take medicine the pain then drug withdrawal that disappears.Take continuously 3 menstrual cycle;

Preparation raw material of the present invention is: Herba Leonuri 10g, Radix Paeoniae Alba 12g, Fructus Rubi 13g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 13g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 13g, Rhizoma Cyperi 11g, Poria cum Radix Pini 12g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 12g, Cortex Albiziae 12g makes oral solutions, 1 dose/d, divide after meal decoction being taken warmly 3 times, serve on 7 doses, continuous 3 menstrual cycle.

1.6 efficacy assessment standard: formulate with reference to " new Chinese medicine guideline of clinical investigations " and " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".Cure: pain disappears, and recurrence is seen at continuous 3 menstrual cycle ends; Take a turn for the better: pain relief or pain disappear, but can not keep more than 3 months; Do not heal: pain has no improvement.

2 results

Two groups of curative effects compare: see Table 1.

Table 1 liang group curative effect is (example) relatively

Annotate: compare with matched group, 1. P＜0.01 clinical data

The specific embodiment:

Embodiment 1: example 1: Hu, woman, 28 years old.Abdominal pain during menstruation increased the weight of more than 3 years.Patient's peritoneoscope right ovary chocolate cyst Excision that moved ahead in 4 years occurred the menstrual period lower abdominal distention pains in nearly 2 years and gradually increases the weight of, and drink cold drink then pain is acute, the hot compress alleviation of pain, medium through measuring, color is dark red piece, companion's vomiting during dysmenorrhea, coolness of extremities, be in a cold sweat, very then faint, purplish tongue is dark, white and thin fur, stringy and hesitant pulse.Ultrasound diagnosis: uterus, adnexa show no obvious abnormalities.Tcm diagnosis is dysmenorrhea, and card belongs to liver-cold blood stasis.Control with dispelling cold by warming the meridian, promoting blood circulation, removing blood stasis and relieving pain, the side does not turn but do not get better always with the SHAOFU ZHUYN DECOCTION plus-minus.Use preparation of the present invention, the side uses: Herba Leonuri 12g, Radix Paeoniae Alba 14g, Fructus Rubi 14g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 15g, vinegar Pericarpium Citri Reticulatae 11g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 13g, Rhizoma Cyperi 11g, Poria cum Radix Pini 12g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g makes oral liquid, and 1 dose 3 of every days, the patient takes medicine to suffer from abdominal pain after 7 doses menstrual period and obviously alleviates.Multiple to begin to take oral liquid as 1 course for the treatment of through front 1 week, treat continuously that stomachache is basic after 3 courses for the treatment of alleviates, successfully became pregnant in 2012.

Embodiment 2: example 2: pay certain, woman, 32 years old.Do not practise contraception unpregnancy more than 6 years of abdominal pain during menstruation companion.Dysmenorrhea generally through front 1～2 day to menstruation the 2nd day obviously, treats that menstrual blood volume is gradually many, have large clot to discharge after pain relief.30 days tides of menstruation, measure medium, color is purple, clot is arranged, with distention and pain of breast before menstruation, there are purple gas, wiry and frequent pulse in the red tongue limit.Tcm diagnosis is dysmenorrhea, and card belongs to the stagnation of liver-QI blood stasis.Control with dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, the side adds and subtracts with Gexia Zhuyu Tang, but always intermittent, DeGrain.Use preparation of the present invention instead, the side uses: Herba Leonuri 13g, Radix Paeoniae Alba 14g, Fructus Rubi 14g, Caulis Perillae 12g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 11g, Oletum Trogopterori 15g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 12g, Rhizoma Cyperi 13g, Poria cum Radix Pini 14g, Rhizoma Atractylodis Macrocephalae 14g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g, the granulation agent, every day, three guarantees were taken after mixing it with water.Advise through front 1 week to take, serve on 7 days.The patient takes medicine through front 1 week in continuous 3 cycles, and symptom is obviously alleviated, and successfully becomes pregnant.

Embodiment 3: poplar, the woman is 32 years old, married.First visit on May 2 in 2011.With through row and after clean the main suit in 2 years of sense lower abdomen pain be admitted to hospital, once from taking YUANHU ZHITONG PIAN and FUKE QIANJIN PIAN etc., weigh when light during stomachache.Menstruation rule previously, amount can, occurred before 2 years through row and after clean sense lower abdomen pain, few through the row amount, color is light red, accompany that the waist hip is aching and tired, both legs are unable, dizzy, tinnitus.Pregnant 1 produces 1, last menstrual period: on July 21st, 2011.Gynecologial examination: pudendum: product type; Vagina: smooth, a small amount of secretions; Cervix uteri: hypertrophy, eck are seen several adenocele; The palace body: the rear position of bending, normal large, in the matter, touch a tender spot (+); Double accessory: all slightly thicken.Look into anti-endometrial antibodies IgG, IgM all (-), CA125 is negative, ultrasound diagnosis: uterus adnexa no abnormality seen.Body of the tongue is light red, white and thin fur, thready pulse without strength.Tcm diagnosis: married woman's stomachache; Western medicine diagnose: endometriosis.Control suitable the kidney invigorating temperature palace, blood-activating analgetic.Make oral liquid with preparation of the present invention.The side uses: Herba Leonuri 12g, Radix Paeoniae Alba 13g, Fructus Rubi 13g, Caulis Perillae 14g, Radix Angelicae Sinensis 13g, Fructus Corni 12g, Radix Polygalae 13g, Herba Taraxaci 14g, Fructus Ligustri Lucidi 11g, Radix Polygoni Multiflori Preparata 13g, Radix Bupleuri 14g, Semen Platycladi 12g, Rhizoma Chuanxiong 14g, Oletum Trogopterori 12g, Radix Salviae Miltiorrhizae 13g, Fructus Foeniculi 12g, Rhizoma Cyperi 13g, Poria cum Radix Pini 13g, Rhizoma Atractylodis Macrocephalae 12g, Rhizoma Zingiberis 13g, Cortex Albiziae 14g, further consultation after serveing on March, private prosecution disappears through row or postmenstrual abdominal pain, and follow-up study 3 months has no recurrence.Now success is conceived.

Claims

1. treat the Chinese medicine preparation that endometriosis causes dysmenorrhea for one kind, it is characterized in that, the parts by weight of various raw materials comprise in the described Chinese medicine preparation: 10～20 parts of Herba Leonuris, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Rubies, 10～20 parts of Caulis Perillaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Polygalaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Bupleuri, 10～20 parts of Semen Platycladi, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Foeniculi, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Poria cum Radix Pinis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Zingiberiss, 10～20 parts of Cortex Albiziaes.

2. described treatment endometriosis causes and it is characterized in that the Chinese medicine preparation of dysmenorrhea according to claim 1, and the parts by weight of various raw materials comprise in the described Chinese medicine preparation: 10～15 parts of Herba Leonuris, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Fructus Rubies, 10～15 parts of Caulis Perillaes, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Fructus Corni, 10～15 parts of Radix Polygalaes, 10～15 parts of Herba Taraxacis, 10～15 parts of Fructus Ligustri Lucidi, 10～15 parts of Radix Polygoni Multiflori Preparata, 10～20 parts of Radix Bupleuri, 10～20 parts of Semen Platycladi, 10～20 parts of Rhizoma Chuanxiongs, 10～20 parts of Oletum Trogopteroris, 10～20 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Foeniculi, 10～20 parts of Rhizoma Cyperis, 10～20 parts of Poria cum Radix Pinis, 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Rhizoma Zingiberiss, 10～20 parts of Cortex Albiziaes.

3. described treatment endometriosis causes and it is characterized in that the Chinese medicine preparation of dysmenorrhea according to claim 1, and the parts by weight of various raw materials comprise in the described Chinese medicine preparation: 10～20 parts of Herba Leonuris, 10～20 parts of the Radix Paeoniae Albas, 10～20 parts of Fructus Rubies, 10～20 parts of Caulis Perillaes, 10～20 parts of Radix Angelicae Sinensis, 10～20 parts of Fructus Corni, 10～20 parts of Radix Polygalaes, 10～20 parts of Herba Taraxacis, 10～20 parts of Fructus Ligustri Lucidi, 10～20 parts of Radix Polygoni Multiflori Preparata, 10～15 parts of Radix Bupleuri, 10～15 parts of Semen Platycladi, 10～15 parts of Rhizoma Chuanxiongs, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Radix Salviae Miltiorrhizaes, 10～15 parts of Fructus Foeniculi, 10～15 parts of Rhizoma Cyperis, 10～15 parts of Poria cum Radix Pinis, 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Rhizoma Zingiberiss, 10～15 parts of Cortex Albiziaes.

4. each described treatment endometriosis causes the Chinese medicine preparation of dysmenorrhea according to claim 1～3, it is characterized in that, the dosage form of described Chinese medicine preparation is: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, injection, plaster or syrup.

One kind as in the claim 1～3 as described in each treatment endometriosis cause and it is characterized in that the preparation method of the Chinese medicine preparation of dysmenorrhea dysmenorrhea, described preparation formulation is oral solutions, its preparation method comprises:

6. described preparation method according to claim 5 is characterized in that, among the described step a, getting raw material adds in the ethanol that 5-10 doubly measures and soaked heating extraction 2 times, each 1-2 hour 1-2 hour, remove supernatant, merge extractive liquid,, the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use becomes component 1.

7. described preparation method according to claim 6, it is characterized in that, among the described step b, the medicinal residues that ethanol extraction is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1～2 hour, and the 100-120 order filters, and is the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, 1.36 extractum when ultrafiltrate concentrating under reduced pressure relative density is 80 ℃, heating is concentrated into paste, and stand for standby use becomes component 2.

8. described preparation method according to claim 6 is characterized in that, among the described step c, above-mentioned two kinds of component pastes is condensed into pasty state, and concentrated solution is with CO 60 sterilizations, and irradiation dose 8k adds dextrin, and then vacuum canning sealing and get final product is directly drunk during use.

One kind according to claim 1～3 in each described treatment endometriosis cause and it is characterized in that the preparation method of the Chinese medicine preparation of dysmenorrhea, described preparation formulation is capsule, its preparation method comprises:

A. described raw material is put into the pulverizer grinding and sieving;

10. the preparation method of described capsule according to claim 9, it is characterized in that, among the described step a, described raw material is put into pulverizer pulverize the rear 120 order dusting covers of crossing, the fine powder amount that enable pass is crossed 120 mesh sieves is reaching 30%, collects by the raw material fine powder of 120 mesh sieves for subsequent use; Among the described step b, the rear remaining particulate matter that sieves is put into the ethanol heating and refluxing extraction 2 times, each 1～2 hour, 2 extracting solution merging are left standstill; Among the described step c, the medicinal residues that above-mentioned ethanol extraction is crossed add 1～2 hour reflux, extract, of 10 times of water gagings heating 1 time; Above-mentioned 3 extracting solution merging is left standstill; In the described steps d, said extracted liquid is merged 1.08 filtrate when the concentrating under reduced pressure relative density is 80 ℃, Recycled ethanol, gained filtrate is adjusted proportion to 1.06, pass into spray dryer and carry out spray drying, the compressed air pressure of crossing the spray dryer shower nozzle is 4kg/m ², the hothouse hot stream temperature is 80 ℃, gets raw material medicated powder; The raw material fine powder that obtains after sieving and ethanol are refined medicated powder to be mixed and incapsulates.