CN105148230A

CN105148230A - Medicine for treating cancer pain and preparation method thereof

Info

Publication number: CN105148230A
Application number: CN201510603010.9A
Authority: CN
Inventors: 刘尚义; 唐东昕; 杨柱
Original assignee: Guiyang College of Traditional Chinese Medicine
Current assignee: Guizhou University of Traditional Chinese Medicine
Priority date: 2015-09-21
Filing date: 2015-09-21
Publication date: 2015-12-16
Anticipated expiration: 2035-09-21
Also published as: CN105148230B

Abstract

The invention discloses medicine for treating cancer pain and a preparation method thereof. The medicine is mainly prepared from crude sichuan aconite roots, raw kusnezoff monkshood roots, arisaema heterophyllum blume, raw pinellia ternate, raw ephedra, cassia twigs, cape jasmine, costus roots, rhizoma sparganii, zedoary, semen arecae slices, camphor, garden balsam, cloves, resina draconis, prepared olibanum, prepared myrrh, capsicum annuum, borneol, dried ginger and ferula. The prepared medicine has the effects of warming yang and eliminating symptoms and activating blood circulation to remove blood stasis, and is suitable for presenters according with dorsal furuncle, gravitational abscess, phlegm nodes, buboes, scleredema pain, various nameless masses and various tumors of western medicine diagnosis.

Description

A kind of medicine for the treatment of cancer pain and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of cancer pain and preparation method thereof, belong to the field of medicine technology.

Technical background

Epithelial Malignant Tumors, i.e. cancer.Along with the mankind change the more and more stronger of nature ability, cause natural environment to go from bad to worse, the M & M of cancer increases in recent years gradually.Nearest data display, the U.S. estimates will have 1,399 in 2006,790 new cancer patients, and has 564, and 830 die from cancer.Since 1999 start, be greater than in 85 years old crowd at the age, cancer has replaced heart disease becomes the highest disease of mortality rate, in 1 ~-14 years old child, also drains into the position of second.And in China, statistics in 2000, interior 48 kinds of cancers, covers 7,300 ten thousand populations, is equivalent to 5.7% of 2000 years Chinese populations.Although, the funds considerable number of the annual input research treatment of cancer in various countries, even to this day it be still the mankind fail a great problem of capturing.

Cancerous pain is one of modal symptom of malignant tumor patient, adds up every day have at least 5,000,000 cancer patients suffer from the torment of pain according to WHO.Newly be diagnosed as in the patient of malignant tumor and about have 1/4 with pain, about have 1/3 patient to accompany cancer pain in therapeutic process, progressive stage about 3/4 is with pain.In addition; pain is one of symptom of fearing most of patient; the pain symptom being difficult to alleviate often causes discomfort, and greatly have impact on the daily routines of patient, self-care ability, affective activity, has a strong impact on interchange between patients and family and friend, patients ' life quality degradation.

To carry out, affect the key factor of life quality in widespread attention as affecting effective antitumor plan for cancer pain.For alleviating and controlling patient's misery, enhancing cancer patient autoimmunity, improve quality of life and the quality of life of cancer patient, the method of conventional pain relieving is injecting anesthetic medicine at present, though these medicines energy reduction of patient pain, but patient's life-time service easily produces dependency, and patient is also easily addicted, the progress along with the state of an illness also needs escalated dose and shortens administration time, therefore side effect is large.

Summary of the invention:

The object of the invention is to, a kind of medicine for the treatment of cancer pain and preparation method thereof is provided.Described medicine has effect of Wen Yanghua Disorder, blood circulation promoting and blood stasis dispelling.Be applicable to carbuncle of yin nature, multiple abscess, sucutaneous nodule, bubo, swollen firmly have a pain, the various tumors of various unknown enclosed mass and Western medicine diagnose meet above-mentioned shower.Evident in efficacy, safety has no side effect.

For solving the problems of the technologies described above, the present invention realizes by the following technical solutions: a kind of medicine for the treatment of cancer pain, calculate by weight, primarily of Radix Aconiti 10-40 part, Radix Aconiti Kusnezoffii 10-40 part, Rhizoma Arisaematis 10-40 part, Rhizoma Pinelliae 10-40 part, Herba Ephedrae 10-40 part, Ramulus Cinnamomi 10-40 part, Fructus Gardeniae 10-40 part, Radix Aucklandiae (Radix Vladimiriae) 10-40 part, Rhizoma Sparganii 10-40 part, Rhizoma Curcumae 10-40 part, bulky 10-40 part, Camphora 1-8 part, Semen Impatientis 1-8 part, Flos Caryophylli 1-8 part, Sanguis Draxonis 1-8 part, Olibanum (processed) 1-8 part, Myrrha (processed) 1-8 part, Fructus Zanthoxyli 1-8 part, Borneolum Syntheticum 1-8 part, Rhizoma Zingiberis 1-8 part and Resina Ferulae 1-8 part are made.

The medicine of aforesaid treatment cancer pain, calculates by weight, primarily of Radix Aconiti 15-25 part, Radix Aconiti Kusnezoffii 15-25 part, Rhizoma Arisaematis 15-25 part, Rhizoma Pinelliae 15-25 part, Herba Ephedrae 15-25 part, Ramulus Cinnamomi 15-25 part, Fructus Gardeniae 15-25 part, Radix Aucklandiae (Radix Vladimiriae) 15-25 part, Rhizoma Sparganii 15-25 part, Rhizoma Curcumae 15-25 part, bulky 15-25 part, Camphora 1-5 part, Semen Impatientis 1-5 part, Flos Caryophylli 1-5 part, Sanguis Draxonis 1-5 part, Olibanum (processed) 1-5 part, Myrrha (processed) 1-5 part, Fructus Zanthoxyli 1-5 part, Borneolum Syntheticum 1-5 part, Rhizoma Zingiberis 1-5 part and Resina Ferulae 1-5 part are made.

The medicine of aforesaid treatment cancer pain, calculates by weight, calculates by weight, primarily of Radix Aconiti 20 parts, Radix Aconiti Kusnezoffii 20 parts, Rhizoma Arisaematis 20 parts, Rhizoma Pinelliae 20 parts, Herba Ephedrae 20 parts, Ramulus Cinnamomi 20 parts, Fructus Gardeniae 20 parts, Radix Aucklandiae (Radix Vladimiriae) 20 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, bulky 20 parts, Camphora 3 parts, Semen Impatientis 3 parts, Flos Caryophylli 3 parts, Sanguis Draxonis 3 parts, Olibanum (processed) 3 parts, Myrrha (processed) 3 parts, Fructus Zanthoxyli 3 parts, Borneolum Syntheticum 3 parts, Rhizoma Zingiberis 3 parts and Resina Ferulae 3 parts are made.

A manufacture method for the medicine of aforesaid treatment cancer pain, gets said medicine, can add adjuvant, also can not add adjuvant, make external preparation.

In the manufacture method of the medicine of aforesaid treatment cancer pain, described external preparation is patch or ointment.

In the manufacture method of the medicine of aforesaid treatment cancer pain, described patch makes like this: get said medicine, is ground into fine powder respectively, proportionally after mixing, then the vaseline adding medication amount 40% stirs evenly, and obtains spice, to mount respectively material, medical mylar and spice load in patch spreading equipment, roll, after shaping, cutting, subpackage, sealing, packaging, to obtain final product.

In the manufacture method of the medicine of aforesaid treatment cancer pain, described ointment makes like this: get Camphora, Semen Impatientis, Flos Caryophylli, Sanguis Draxonis, Olibanum (processed), Myrrha (processed), Fructus Zanthoxyli, Borneolum Syntheticum, Rhizoma Zingiberis and Resina Ferulae mixing, porphyrize, obtains mixed-powder, for subsequent use; Get all the other medicines, decoct with water secondary, first time adds 8 times amount soak by water 2 hours, and second time adds 6 times amount soak by water 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.05 ~ 1.15; Get the sorbitol of extractum amount 7%, the glycerol of 8% and above-mentioned mixed-powder, add in above-mentioned extractum, be heated to 80 DEG C and make dissolving, obtain A product; Separately get the stearic acid of extractum amount 8%, 7% tristearin, the Yellow Vaselin of 3%, the lanoline of poly-Pyrusussuriensis fat 80,2% of 8% and the sucrose stearate of 1% be heated to 80 DEG C, make melting, obtain B product, by A product and the mixing of B product, emulsifying 15 minutes, 80 DEG C are incubated 30 minutes, add the benzoic acid of the amount of making 0.6% and the ethyl hydroxybenzoate mixing of 0.15%, fill, to obtain final product.

Medicine of the present invention is primarily of Radix Aconiti, and Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, Herba Ephedrae, Ramulus Cinnamomi, Fructus Gardeniae, Radix Aucklandiae (Radix Vladimiriae), Rhizoma Sparganii, Rhizoma Curcumae, bulky, Camphora, Semen Impatientis, Flos Caryophylli, Sanguis Draxonis, Olibanum (processed), Myrrha (processed), Fructus Zanthoxyli, Borneolum Syntheticum, Rhizoma Zingiberis and Resina Ferulae are made.Wherein Radix Aconiti, English name AconiteRoot, another name goose is spent, the ornamental work of iron, nontoxic.Be born in grass slope, mountain region or shrubbery.There is expelling wind and removing dampness, effect of antalgic.Have a pain for anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type.Be used for the treatment of the disease such as anemofrigid-damp arthralgia, arthralgia.Take orally after the general process of preparing Chinese medicine.Radix Aconiti tincture external energy chafe, produces feeling of numbness then, therefore the outer analgesics being used as some neuralgia and rheumatism.Radix Aconiti Kusnezoffii, Chinese medicine name.For the tuber of Ranunculaceae herbaceos perennial Aconitum carmichjaelii Debx. (wild species) or Aconitum kusnezoffii Reichb.Pungent, bitter, heat; Very toxic.GUIXIN, liver,kidney,spleen warp.There is expelling wind and removing dampness, effect of antalgic.For anemofrigid-damp arthralgia, arthralgia, trusted subordinate's cold type of pain, colic of cold type is had a pain, narcotic analgesic.Rhizoma Arisaematis, Chinese medicine, takes from the rhizome of Rhizoma Arisaematis (aroid Rhizoma Arisaematis Arisaemaerubescens (Wall.) Schott., Arisaema heterophyllum B1. ArisaemaheterophyllumBlume or arisaema amurense Maxim ArisaemaamurenseMaxim.).Bitter, pungent, temperature; There is drying dampness to eliminate phlegm, expelling wind and relieving convulsion, effect of mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.Rhizoma Pinelliae is the tuber of the Araeceae herbaceos perennial Rhizoma Pinelliae, and effect is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, globus hystericus vexed for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass etc.Raw with can external treatment carbuncle sucutaneous nodule, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) be used for stopping nausea and vomiting by lowering the adverse flow of QI.Pungent, temperature.Poisonous.Return spleen, stomach, lung meridian.Herba Ephedrae, Rawephedra, Herba Ephedrae diaphoresis diuresis is in comparatively strong, and moxibustion Herba Ephedrae diaphoresis power is weak, is applicable to cough and asthma.Ramulus Cinnamomi, rectification of name: Cortex Cinnamomi (formal name used at school: CinnamomumcassiaPresl), has another name called beautiful osmanthus, Cortex cinnamomi japonici (Ramulus Cinnamomi) etc., belongs to Laurales, the medium megaphanerophyte of Lauraceae; Annotinous branch is cylindrical, terminal bud perula width egg shape, green leaf alternate, and oblong is to nearly lanceolar; Floral white, is about 4.5mm; Fruit is oval, and black purple time ripe, without hair; 6 ~ August of florescence, fruit phase 10 ~ December.Its nature and flavor are pungent, sweet, temperature, enter lung, the heart, urinary bladder channel, cure mainly the conventional drugs for dispelling internal cold of interior cold, there is effect of complement sun, promoting blood circulation, warming the spleen and stomach, normal with invigorating the liver and kidney medicine, fill blood medicine compatibility, treats insufficiency of kidney-YANG, decline of the fire from the gate of life, cold extremities faint pulse, treat coldness and pain in the epigastrium, arthralgia due to cold lumbago with other drugs for dispelling internal cold compatibility, there is the effect of significantly analgesia and anti-cancer and cancer-preventing.Existing various wind dispelling oils medicine is if menthocamphorate, rheumatism wet goods are all containing cassia oil composition.Ramulus Cinnamomi energy diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, dispersing cold for relieving pain.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea dysmenorrhea; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Phlegm retention; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Fructus Gardeniae (formal name used at school: Gardeniajasminoides), the leaf of Fructus Gardeniae, flower, fruit and root all can be used as medicine, and have effect of heat clearing away, pathogenic fire purging, removing toxic substances, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.1. " herbal classic ": " bitter in the mouth, cold." Radix Aucklandiae (Radix Vladimiriae) also makes Saussurea lappa Clarke (AucklandialappaDecne.) be the perennial herb of Genus Saussurea, high 100-200 centimetre.Main root is sturdy, cylindrical, tool special aroma.Avette or the Yangtze River Delta shape of blade triangular shape, leaf margin is shallow to be split or wavy; Stem leaf oblong.Achene is linear.7 ~ August of florescence, really 8 ~ October of phase.Be born in the ground such as Yunnan, its root can be used for stomach invigorating relieving distension, promoting the flow of QI for relieving the stagnancy, pain relieving are antiabortive.Cure mainly promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach.For chest and abdomen swelling and pain, vomiting, has loose bowels, dysentery tenesmus.Rhizoma Sparganii, Chinese medicine name.For Sparganiaceae plant rhizoma scirpi Sparganiumstolonierum, the dry tuber of Buch.-Ham..Spring winter to next year excavates, and clean, crust of pruning, dries.Be distributed in northeast, the Yellow River, basin, the middle and lower reach of Yangtze River and Tibet.There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, dysmenorrhea, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, food stagnation distending pain.Nature and flavor: pungent, bitter are flat.Return liver, spleen channel.Rhizoma Curcumae other Cheng Shu medicine, Curcuma Shu, blue or green Rhizoma Zingiberis Recens, evil mind Rhizoma Zingiberis Recens, Rhizoma Curcumae Longae, Latin name: Curcumazedoaria (Christm.) Rosc., Rhizoma Curcumae is Zingiberaceae, Curcuma perennial root draft, and this product is the dry rhizome of zingiberaceous plant Rhizoma Curcumae CurcumaphaeocaulisVal., Guangxi zedoary CurcumaKwangsiensisS.G.LeeetC.F.Liang or RADIX CURCUMAE CurcumawenyujinY.H.ChenetC.Ling.The latter practises title " Curcuma wenyujin ".Winter, stem and leaf was excavated after withering, and cleaned, steamed or boil to the saturating heart, dry or remove fibrous root and impurity after cold drying.Plant height about 1 meter; Rhizome is cylindrical, meat, fragrance as tool Camphora, faint yellow or white; Elongated or the end of root enlarges into tuber.Cultivation or wild under Lin Yin, is distributed in India, Malaysia and all over China.Promoting the circulation of QI to relieve pain, long-pending eliminating stagnation, removing blood stasis effect can be controlled.Pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.Promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: for the amenorrhea of qi depression to blood stasis, chest and hypochondrium, stomachache and lump in the abdomen lump etc.Often join Rhizoma Sparganii.Promoting digestion and removing stagnation: for the stomach abdominal distention and pain of eating accumulation, often join Fructus Hordei Germinatus (parched to brown), Semen Arecae Prepareta.Camphora, Cinnamomumcamphora (L.) PreslLauruscamphoraL. is the branch of canella Camphor tree, dry, leaf and root, through refining obtained crystalline particulate.Camphora has orifice opening, qi stagnation removing, wards off foul, killing parasites for relieving itching, reducing swelling and alleviating pain effect, cures mainly the symptoms such as scabies pruritus, traumatic pain, toothache.Main component is pure gum camphor (d-Camphora), is camphane compounds.Camphora is applied to skin gentle stimulation and antisepsis.Firmly embrocate and sent out effect red; Dab is similar Herba Menthae then, has refrigerant sense, and this is the effect owing to stimulating Cold receptor.It also has slight local anesthesia effect.For gastrointestinal tract mucous, Camphora has stimulation, stomach is basked and comfortable, then can produce in a large number and feel sick and vomiting.Analgesia, itching-relieving action is had clinically with camphorated oil.Oral have wind dispelling effect and slight phlegm-dispelling functions.Camphora through mucous membrane, subcutaneous, muscle all easily absorb.Oral absorption is also fast.Detoxify in liver quite rapid, be oxidized to camphyl alcohol, then be combined with glucuronic acid and discharge in urinating.Semen Impatientis, GardenBalsamSeed is the seed of Balsaminaceae plant Impatientis.In autumn, gather after fruit maturation, the impurity such as removing peel, dry.Dry seed is slightly oblate spheroid extremely flat oval, long 2.5 ~ 3 millimeters, wide 2 ~ 3 millimeters.Seed coat russet, or brown, and gather little den and orange-yellow billet stricture of vagina on surface.Hilum is positioned at the narrow end of seed, slightly outstanding, matter is hard, is good: containing balsaminasterol, Parinaric Acid, Saponin, fatty oil, polysaccharide, protein, aminoacid, volatile oil with full grains person, and the flavonoid such as the polysaccharid glucoside of Quercetin and the derivant of nimbecetin.Nature and flavor with return through: micro-hardship, pungent, temperature; Slightly poisonous.Return spleen, Liver Channel.Function with cure mainly: anticancer, the scattered silt of relieving internal heat is subsided a swelling.Removing blood stasis softening the hard mass, removing food stagnancy.Yong Yu WEIJIA mass in the abdomen, amenorrhea, dysphagic.Flos Caryophylli, Syzygiumaromaticum (L.) Merr.EtPerry, be the alabastrum of Myrtaceae aiphyllium plant EugeniacaryophyllataThunb, Flos Caryophylli and fruit (Fructus Caryophylli), property is pungent, taste temperature.Enter lung, spleen, stomach, kidney four warp.Effect: warming middle-JIAO, warming the kidney, sending down the abnormal ascending QI.Cure mainly: control singultus, vomiting, regurgitation, dysentery, trusted subordinate's cold type of pain, mass beside the umbilicus, hernia, ringworm.Sanguis Draxonis, DaemonoropsdracoBl., Chinese medicine name.The resin oozed out for babassu Sanguis Draxonis fruit is through being processed into.Be distributed in the places such as Indonesia Java, Sumatera, Borneo.There is analgesic therapy of invigorating blood circulation, removing stasis to stop bleeding, effect of promoting tissue regeneration and ulcer healing.For traumatic injury, trusted subordinate's stasis of blood pain, traumatic hemorrhage, skin infection is not held back.Nature and flavor: sweet, salty are flat.GUIXIN, Liver Channel.To invigorate blood circulation analgesic therapy, removing stasis to stop bleeding, expelling pus and promoting granulation.Effect, for traumatic injury, trusted subordinate's stasis of blood pain, traumatic hemorrhage, skin infection is not held back.Olibanum, Chinese medicine name.For the resin that olive subject plant Boswellia carterii BoswelliacarteriiBirdw. and congener BoswelliabhaurdajianaBirdw. bark ooze out.Be divided into Somalia's Olibanum and Gum Olibanum Ethiopia, often kind of Olibanum again man's cap used in ancient times is Olibanum pearl and former Olibanum.Nature and flavor: pungent, bitter, temperature.. GUIXIN, liver, spleen channel.Blood-activating and qi-promoting pain relieving, effect of detumescence and promoting granulation.For obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation, lump in the abdomen is suffered from abdominal pain, rheumatic arthralgia, the contracture of muscle arteries and veins, traumatic injury, carbuncle skin infection.Myrrha, Chinese medicine name.For olive subject plant Herba Violae tree CommiphoramyrrhaEngl. or the dry resin breathing out Herba Violae tree CommiphoramolmolEngl..Be divided into natural Myrrha and gum opoponax.Be distributed in the ground such as Somalia, Ethiopia and south, the Arabia Peninsula.There is dissipating blood stasis analgesic therapy, effect of detumescence and promoting granulation.Be usually used in obstruction of qi in the chest and cardialgia, gastralgia, dysmenorrhea amenorrhea, postpartum stagnation ， mass in the abdomen is suffered from abdominal pain, rheumatic arthralgia, traumatic injury, the treatment of the diseases such as carbuncle skin infection.GUIXIN, liver, spleen channel.Acrid in the mouth, hardship, property is put down.Fructus Zanthoxyli, Chinese medicine name.For the dry mature skin of rutaceae Capsicum annuum L. (fragrant green pepper, Zanthoxylum schinifolium, Pericarpium Zanthoxyli, Canis familiaris L. green pepper) ZanthoxylumschinifoliumSieb.etZucc. or Pericarpium Zanthoxyli (another name for Sichuan Province green pepper, Fructus Zanthoxyli, Capsicum tetragonum, pericarpium zanthoxyli bungeani, Radix Campylotropis Hirtella (Herba Myrsines Africanae)) ZanthoxylumbungeanumMaxim..To gather autumn mature fruit, dry, remove seed and impurity.Life is used or is fried and uses.Nature and flavor: pungent, numb, temperature.Return spleen, stomach, kidney channel.Green pepper is red: warming middle-JIAO to relieve pain, effect of killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation; External treatment eczema, pudendal pruritus.Borneolum Syntheticum, Borneol, has another name called sheet brain, Fructus Citri tangerinae sheet, Blumeae preparatum Tabellae, Borneolum Syntheticum, MEIHUA BINGPIAN, Dipterocarpus pilosus, Flos Mume brain, Borneolum Syntheticum brain, Mei Bing etc., is through steam distillation and recrystallization and obtaining by Compositae Herba Blumeae Balsamiferae stem and leaf or canella Borneolum Syntheticum Camphor tree branch and leaf.Also useful Oleum Terebinthinae obtains through a series of chemical method technique.It can be used for excess syndrome of stroke coma, for conjunctival congestion and swelling pain, sore throat aphtha, to swell and ache for skin infection, does not hold back after bursting." Newly Revised Canon of Materia Medica ": " main trusted subordinate's pathogen, rheumatism is gathered, and deaf, improving eyesight, goes conjunctival congestion skin nebula." Tang Materia Medica: " acrid in the mouth is bitter, is slightly cold." enter the heart, Liver Channel.Rhizoma Zingiberis, Chinese medicine name.For the dry rhizome of zingiber Zingiberoj-jicinaleRosc..Winter excavates, and removing fibrous root and silt, dry or cold drying.Take advantage of fresh slices to dry or cold drying person is called " dried ginger slice ".Acrid in the mouth, hot in nature.Return spleen, stomach, kidney, the heart, lung meridian.Have warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, effect of warming the lung to resolve fluid-retention.With treating in coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, cold fluid-retention is breathed with cough.Resina Ferulae, Chinese medicine name.For the resin of samphire Ferula sinkiangensisK.M.Shen FerulasinkiangensisK.M.Shen or Ferula fukanensis K.M.Shen FerulafukanensisK.M.Shen.The end of spring and the beginning of summer full-bloom stage to just the fruit phase all can gather, but is gathered as good with full-bloom stage.Gradation is cut from stem top toward declivity, collects the emulsion resin of oozing out, dries in the shade.Nature and flavor: bitter, pungent, temperature.Return spleen, stomach warp.There is removing food stagnancy, change abdominal mass, loose painful abdominal mass, effect of parasite killing.For meat stagnation, blood stasis addiction abdominal mass, mass in abdomen, abdominal pain due to worm stagnation.Bulky, the traditional Chinese medical science is used as the cards such as treatment malnutrition due to parasitic infestation, dyspepsia, abdominal distention, edema, beriberi.Its peel is called " large father's skin ", energy circulation of qi promoting, diuretic, detumescence.Except fruit, leaves is edible also.In Wanning, Lingshui, Sanya one be with, and eats Semen Arecae and become important custom.Be stained with condiment after Semen Arecae section, carefully chew and chew slowly, told clear water, again Sheng Danjin, eat rear flush up to one's ears, as the verse of Soviet Union and Eastern Europe slope impromptu " two cheek red tides are once charming, and who knows that you are liquor-saturated Semen Arecaes " write.On New Year's Day or other festivals and propose, become engaged and manage a wedding, Semen Arecae is indispensable especially.Chewing food Semen Arecae can be liquor-saturated, therefore also known as " liquor-saturated Semen Arecae ".Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica cloud: " (Semen Arecae) stays leaf to close freshwater mussel ash to chew it, can ward off miasma scrofula, remove bad odor in the heart with holding up."

Motherland's medical science is thought: " long-pending person, cloudy gas also, therefore sinks and lies prostrate." " pain person, cold is also many." carbuncle of yin nature, multiple abscess, sucutaneous nodule, bubo, the shaping of the gathering lump gas that mostly is the evil poison of YIN-cold stays to crouch and do not go, QI and blood is not smooth, phlegm resistance, and accumulating in the course of time then, the vim and vigour stasis of blood is stagnant, venation is obstructed.Therefore multiselect Wen Yanghua Disorder of the present invention, the medicine of current vim and vigour.Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, Herba Ephedrae, Semen Impatientis, Resina Ferulae etc. all have the anticancer effect of Wen Yanghua Disorder, are monarch drug; Fructus Gardeniae, Radix Aucklandiae (Radix Vladimiriae), Rhizoma Sparganii, Rhizoma Curcumae, bulky, Flos Caryophylli, Sanguis Draxonis, breast processed such as not to have at the blood circulation promoting and blood stasis dispelling circulation of qi promoting, are ministerial drug; Ramulus Cinnamomi, Rhizoma Zingiberis, the pungent temperature of Fructus Zanthoxyli is supporing yang, is adjuvant drug; The pungent perfume infiltration of Borneolum Syntheticum, Camphora, for making medicine.Full cream drug is high strong, and penetration is strong, has certain active anticancer and blood stasis-eliminating and stagnation-dissipating function.Play effect of Wen Yanghua Disorder, blood circulation promoting and blood stasis dispelling altogether.Be applicable to carbuncle of yin nature, multiple abscess, sucutaneous nodule, bubo, swollen firmly have a pain, the various tumors of various unknown enclosed mass and Western medicine diagnose meet above-mentioned shower.

Compared with prior art, described medicine can be used for treating cancerous pain, evident in efficacy, and safety has no side effect.Reach the object of invention.

Applicant carried out following experiments, provable the present invention has effective effect;

Experimental example 1 effect experiment

1 material:

1.1 animals and instrument female sd inbred rats 30, weight 250 ~ 300g, VonFrey cilium mechanical stimulus instrument (Northcoastmedical company of the U.S.), radiation temperature-sensitive stimulation instrument (the optical instrument Engineering Technical Research Centre development of country of Zhejiang University).

1.2 medicine medicine of the present invention, makes by embodiment 1; Control drug, morphine sulfate;

2 animal models make: binding of lying on the back after rat anesthesia, skin is cut from left tibias top, separating muscle, expose tibia, use 20ml syringe needle puncture punching, change 10ul syringe afterwards and enter medullary cavity, slowly inject 3ulMADB-106 cell, with bone wax sealing after injection, sew up.Clinical follow every rat ordinary circumstance, weight, feed, activity and tibia localized variation, namely can be used for experiment after 5d.

3 animal grouping and administrations: complete the rat totally 30 that bone cancer pain model is set up, all mouse back defeatherings, are divided into 3 groups after rat rest 5d at random, often organize 10, of the present invention group (C group); Morphine sulfate group: after lumbar injection morphine sulfate (20mg/kg), then the glacial acetic acid 10mL/kg of lumbar injection 0.7%; Medicine group of the present invention: external application medicine of the present invention after the defeathering of back, after administration 30min, then the glacial acetic acid 10mL/kg of lumbar injection 0.7%; Blank group: external application and the onesize blank medical cloth glue cream of cancer pain plaster area after the defeathering of back, then the glacial acetic acid 10mL/kg of lumbar injection 0.7% immediately.Respectively at after modeling 3,7,10d VonFrey filament method (mechanical hyperalgesia) measures machinery contracting pawl reflex threshold (MWT) of 1h after rat administration; Thermostimulation paw withdrawal latency (TWL) is measured by Harg-reaves method (thermal hyperalgesia).The results are shown in Table 1, table 2.

4 statistical methods: data represent with mean ± standard deviation (x ± s), application SPSS13.0 software statistics is analyzed.Compare employing one factor analysis of variance between group, compare between two and adopt Dunnett.t inspection.

Table 1 is on the impact of bone cancer pain rat model MWT

Note: compare with blank group, * P<0.05; Compare with B, C group, #P<0.05.

Table 2 is on the impact of bone cancer pain rat model TWL

Note: compare with blank group ,+P<0.05; Compare with B, C group, & P<0.05.

Result shows: the MWT of of the present invention group of rat obviously increases, and TWL obviously extends (P<0.05), and medicine of the present invention effectively can treat cancer pain.

Experimental example 2 toxicity test

1, experimental animal and environment: new zealand white rabbit, body weight 2.0-3.0kg.Your doctor's Experimental Animal Center provides: SCXK (Guizhou Province) 2012-0001, experimental animal occupancy permit: SYXK (Guizhou Province) 2014-001.

Temperature: 18-23 DEG C, humidity: 40-70%, single cage is fed.

2, sample treatment: by medicine of the present invention, after being mixed in proportion, mixes well for subsequent use with appropriate warm water.

3, test method: experimental animal selects health after quarantining 3 days, the rabbit 4 adult, skin is harmless, 24h before test, cut by hair spinal column both sides, experimental animal back, not lesional epidermis, unhairing scope is respectively 3cm*3cm.Application area 2.5cm*2.5cm, get medicine of the present invention (making by embodiment 1) 0.5g and be applied on the skin of unhairing of side, opposite side in contrast, is smeared once every day, smears 14 days continuously.From second day, smear front cropping at every turn, remove left drug with warm water, observed result after 1 hour, and observe other toxic actions except zest.The results are shown in Table 3.

Table 3 skin irritation test result

4, conclusion: the dermoreaction integral mean of medicine of the present invention repeatedly Skin Irritation Test is 1.70, and medicine of the present invention repeatedly Skin Irritation Test belongs to subexcite.

Below in conjunction with embodiment, invention is further described, but not as the foundation limited the present invention.

Detailed description of the invention:

Embodiment 1.

Formula: Radix Aconiti 200g, Radix Aconiti Kusnezoffii 200g, Rhizoma Arisaematis 200g, Rhizoma Pinelliae 200g, Herba Ephedrae 200g, Ramulus Cinnamomi 200g, Fructus Gardeniae 200g, Radix Aucklandiae (Radix Vladimiriae) 200g, Rhizoma Sparganii 200g, Rhizoma Curcumae 200g, bulky 200g, Camphora 30g, Semen Impatientis 30g, Flos Caryophylli 30g, Sanguis Draxonis 30g, Olibanum (processed) 30g, Myrrha (processed) 30g, Fructus Zanthoxyli 30g, Borneolum Syntheticum 30g, Rhizoma Zingiberis 30g and Resina Ferulae 30g.

Technique: get said medicine, is ground into fine powder respectively, and proportionally after mixing, then the vaseline adding medication amount 40% stirs evenly, and obtains spice, to mount respectively material, medical mylar and spice load in patch spreading equipment, roll, after shaping, and cutting, subpackage, sealing, packaging, obtains unguentum.

Usage and dosage: each one pastes, every note 6-8 hour.Contraindication: only for external, anemia of pregnant woman, skin surface ulceration and this product allergy sufferers is forbidden.Specification: size 13cm × 13cm, clean medicine diameter 7.7cm, dose thickness 0.6mm, heavy about the 10g of medicine.

Embodiment 2.

Formula: Radix Aconiti 300g, Radix Aconiti Kusnezoffii 300g, Rhizoma Arisaematis 300g, Rhizoma Pinelliae 300g, Herba Ephedrae 300g, Ramulus Cinnamomi 300g, Fructus Gardeniae 300g, Radix Aucklandiae (Radix Vladimiriae) 300g, Rhizoma Sparganii 300g, Rhizoma Curcumae 300g, bulky 300g, Camphora 40g, Semen Impatientis 40g, Flos Caryophylli 40g, Sanguis Draxonis 40g, Olibanum (processed) 40g, Myrrha (processed) 40g, Fructus Zanthoxyli 40g, Borneolum Syntheticum 40g, Rhizoma Zingiberis 40g and Resina Ferulae 40g.

Technique: technique: get Camphora, Semen Impatientis, Flos Caryophylli, Sanguis Draxonis, Olibanum (processed), Myrrha (processed), Fructus Zanthoxyli, Borneolum Syntheticum, Rhizoma Zingiberis and Resina Ferulae mixing, porphyrize, obtains mixed-powder, for subsequent use; Get all the other medicines, decoct with water secondary, first time adds 8 times amount soak by water 2 hours, and second time adds 6 times amount soak by water 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.05 ~ 1.15; Get the sorbitol of extractum amount 7%, the glycerol of 8% and above-mentioned mixed-powder, add in above-mentioned extractum, be heated to 80 DEG C and make dissolving, obtain A product; Separately get the stearic acid of extractum amount 8%, 7% tristearin, the Yellow Vaselin of 3%, the lanoline of poly-Pyrusussuriensis fat 80,2% of 8% and the sucrose stearate of 1% be heated to 80 DEG C, make melting, obtain B product, by A product and the mixing of B product, emulsifying 15 minutes, 80 DEG C are incubated 30 minutes, add the benzoic acid of the amount of making 0.6% and the ethyl hydroxybenzoate mixing of 0.15%, fill, obtains ointment.

Embodiment 3.

Formula: Radix Aconiti 100g, Radix Aconiti Kusnezoffii 100g, Rhizoma Arisaematis 100g, Rhizoma Pinelliae 100g, Herba Ephedrae 100g, Ramulus Cinnamomi 100g, Fructus Gardeniae 100g, Radix Aucklandiae (Radix Vladimiriae) 100g, Rhizoma Sparganii 100g, Rhizoma Curcumae 100g, bulky 100g, Camphora 20g, Semen Impatientis 20g, Flos Caryophylli 20g, Sanguis Draxonis 20g, Olibanum (processed) 20g, Myrrha (processed) 20g, Fructus Zanthoxyli 20g, Borneolum Syntheticum 20g, Rhizoma Zingiberis 20g and Resina Ferulae 20g.

Technique: get Camphora, Semen Impatientis, Flos Caryophylli, Sanguis Draxonis, an Olibanum, Myrrha (processed), Fructus Zanthoxyli, Borneolum Syntheticum, Rhizoma Zingiberis and Resina Ferulae mixing, porphyrize, obtains mixed-powder, for subsequent use; Get all the other medicines, decoct with water secondary, first time adds 8 times amount soak by water 2 hours, and second time adds 6 times amount soak by water 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.05 ~ 1.15;

Separately get the rubber of extractum weight 50%, the Colophonium of 50%, the vaseline of 10% and 20% lanoline heating and melting, then add in above-mentioned extractum, mix with the glycerol of extractum weight 15%, the zinc oxide of 60% and above-mentioned mixed-powder, stir 15-30 minute, obtain spice, material of mounting respectively, medical mylar and spice load in patch spreading equipment, roll, after shaping, cutting, subpackage, sealing, packaging, to obtain final product.

Claims

1. treat a medicine for cancer pain, it is characterized in that: calculate by weight, primarily of Radix Aconiti 10-40 part, Radix Aconiti Kusnezoffii 10-40 part, Rhizoma Arisaematis 10-40 part, Rhizoma Pinelliae 10-40 part, Herba Ephedrae 10-40 part, Ramulus Cinnamomi 10-40 part, Fructus Gardeniae 10-40 part, Radix Aucklandiae (Radix Vladimiriae) 10-40 part, Rhizoma Sparganii 10-40 part, Rhizoma Curcumae 10-40 part, bulky 10-40 part, Camphora 1-8 part, Semen Impatientis 1-8 part, Flos Caryophylli 1-8 part, Sanguis Draxonis 1-8 part, Olibanum (processed) 1-8 part, Myrrha (processed) 1-8 part, Fructus Zanthoxyli 1-8 part, Borneolum Syntheticum 1-8 part, Rhizoma Zingiberis 1-8 part and Resina Ferulae 1-8 part are made.

2. the medicine for the treatment of cancer pain as claimed in claim 1, is characterized in that: calculate by weight, primarily of Radix Aconiti 15-25 part, Radix Aconiti Kusnezoffii 15-25 part, Rhizoma Arisaematis 15-25 part, Rhizoma Pinelliae 15-25 part, Herba Ephedrae 15-25 part, Ramulus Cinnamomi 15-25 part, Fructus Gardeniae 15-25 part, Radix Aucklandiae (Radix Vladimiriae) 15-25 part, Rhizoma Sparganii 15-25 part, Rhizoma Curcumae 15-25 part, bulky 15-25 part, Camphora 1-5 part, Semen Impatientis 1-5 part, Flos Caryophylli 1-5 part, Sanguis Draxonis 1-5 part, Olibanum (processed) 1-5 part, Myrrha (processed) 1-5 part, Fructus Zanthoxyli 1-5 part, Borneolum Syntheticum 1-5 part, Rhizoma Zingiberis 1-5 part and Resina Ferulae 1-5 part are made.

3. the medicine for the treatment of cancer pain as claimed in claim 2, is characterized in that: calculate by weight, primarily of Radix Aconiti 20 parts, and Radix Aconiti Kusnezoffii 20 parts, Rhizoma Arisaematis 20 parts, Rhizoma Pinelliae 20 parts, Herba Ephedrae 20 parts, Ramulus Cinnamomi 20 parts, Fructus Gardeniae 20 parts, Radix Aucklandiae (Radix Vladimiriae) 20 parts, Rhizoma Sparganii 20 parts, Rhizoma Curcumae 20 parts, bulky 20 parts, Camphora 3 parts, Semen Impatientis 3 parts, Flos Caryophylli 3 parts, Sanguis Draxonis 3 parts, Olibanum (processed) 3 parts, Myrrha (processed) 3 parts, Fructus Zanthoxyli 3 parts, Borneolum Syntheticum 3 parts, Rhizoma Zingiberis 3 parts and Resina Ferulae 3 parts are made.

4. a manufacture method for the medicine of the treatment cancer pain according to any one of claim 1-3, is characterized in that: get said medicine, can add adjuvant, also can not add adjuvant, make external preparation.

5. the manufacture method of the medicine for the treatment of cancer pain as claimed in claim 4, is characterized in that: described external preparation is patch or ointment.

6. the manufacture method of the medicine for the treatment of cancer pain as claimed in claim 5, is characterized in that: described patch makes like this: get said medicine, is ground into fine powder respectively, proportionally after mixing, then the vaseline adding medication amount 40% stirs evenly, and obtains spice, to mount respectively material, medical mylar and spice load in patch spreading equipment, roll, after shaping, cutting, subpackage, sealing, packaging, to obtain final product.

7. the manufacture method of the medicine for the treatment of cancer pain as claimed in claim 5, it is characterized in that: described ointment makes like this: get Camphora, Semen Impatientis, Flos Caryophylli, Sanguis Draxonis, Olibanum (processed), Myrrha (processed), Fructus Zanthoxyli, Borneolum Syntheticum, Rhizoma Zingiberis and Resina Ferulae mixing, porphyrize, obtains mixed-powder, for subsequent use; Get all the other medicines, decoct with water secondary, first time adds 8 times amount soak by water 2 hours, and second time adds 6 times amount soak by water 1.5 hours, collecting decoction, filters, and when filtrate is concentrated into 80 DEG C, relative density is the extractum of 1.05 ~ 1.15; Get the sorbitol of extractum amount 7%, the glycerol of 8% and above-mentioned mixed-powder, add in above-mentioned extractum, be heated to 80 DEG C and make dissolving, obtain A product; Separately get the stearic acid of extractum amount 8%, 7% tristearin, the Yellow Vaselin of 3%, the lanoline of poly-Pyrusussuriensis fat 80,2% of 8% and the sucrose stearate of 1% be heated to 80 DEG C, make melting, obtain B product, by A product and the mixing of B product, emulsifying 15 minutes, 80 DEG C are incubated 30 minutes, add the benzoic acid of the amount of making 0.6% and the ethyl hydroxybenzoate mixing of 0.15%, fill, to obtain final product.